                         SEQUENCE LISTING

<110>  Leiden University Medical Center
 
<120>  Methods and means for diagnosing and treatment of osteoarthritis

<130>  P6003347PCT

<150>  EP 06118594.8
<151>  2006-08-08

<160>  4     

<170>  PatentIn version 3.3

<210>  1
<211>  6688
<212>  DNA
<213>  human

<400>  1
ggctgcagag agaggcactt tgcaccacag acagatagca agaagggaaa gacagagagt     60

gagaaaaaag aggagtcagt cgctcctggg gaagggagag agtgagactg ggagaaagag    120

aagcacagaa agtgtgtgta aaacggagta aagaaagaaa aaaaaaaaac tacccttaaa    180

gcacatttaa aaaaaaaaaa aactctggca attcaagaaa gaaacaggct acgtttaaag    240

agcatagaga caatgaaaga ctaaagaaaa ttttaaaatc tctgccacag tctcataggt    300

gcttggaaat gaaagtagaa ctgcctgtct ttaacggact ctgacagagg taactggatt    360

agggacgagt acgccagctt tttttttttt tttttttttt tttttttaac atcttaaatc    420

ctgaaaaaaa aaaaaaaaaa aaaaaaaagg cagcagctcc gaattgaatg aattgatggg    480

cacactccaa ctgctgggct ggagagactg gacttagtct tgccatttct gcttctttga    540

aagaggagac aacttgggct tccttttaat ttagtttttt ttccccttct cccccaaccc    600

ccaaccttcc cccttacctc ccccaccccc tttatcacca cccccctttt aaataagagg    660

gtgaagggga accagagcgc acaagggaac tgactcagga ggcagagaag atgggcatcc    720

tcagcgtaga cttgctgatc acactgcaaa ttctgccagt ttttttctcc aactgcctct    780

tcctggctct ctatgactcg gtcattctgc tcaagcacgt ggtgctgctg ttgagccgct    840

ccaagtccac tcgcggagag tggcggcgca tgctgacctc agagggactg cgctgcgtct    900

ggaagagctt cctcctcgat gcctacaaac aggtgaaatt gggtgaggat gcccccaatt    960

ccagtgtggt gcatgtctcc agtgcagaag gaggtgacaa cagtggcaat ggtacccagg   1020

agaagatagc tgagggagcc acatgccacc ttcttgactt tgccagccct gagcgcccac   1080

tagtggtcaa ctttggctca gccacttgac ctcctttcac gagccagctg ccagccttcc   1140

gcaaactggt ggaagagttc tcctcagtgg ctgacttcct gctggtctac attgatgagg   1200

ctcatccatc agatggctgg gcgataccgg gggactcctc tttgtctttt gaggtgaaga   1260

agcaccagaa ccaggaagat cgatgtgcag cagcccagca gcttctggag cgtttctcct   1320

tgccgcccca gtgccgagtt gtggctgacc gcatggacaa taacgccaac atagcttacg   1380

gggtagcctt tgaacgtgtg tgcattgtgc agagacagaa aattgcttat ctgggaggaa   1440

agggcccctt ctcctacaac cttcaagaag tccggcattg gctggagaag aatttcagca   1500

agagatgaaa gaaaactaga ttagctggtt aaaggtatga ttataagaga gcttattgtt   1560

ttaaaaagtt atataaaggc aaggaaatta agaactgaat ccatatttca acagagccct   1620

attggcttac tgaaagacag gagtttatct atcggaagaa catgaatctc taacagctcc   1680

atacttcttt cactactcaa atggcattgg gctgagtaag taaccatatc acctctcttc   1740

ttagtaaaaa gccctatgtg aaaagatccc aagatggaga ggaagaaacg ctaattcagc   1800

atgtgttcat tctgcattga gaaggaactg atacatctga tgcatgcttt gagaccagaa   1860

gaaaagactt acctgaataa ttactacatt agggaagcta ctgtctacgt taagataaag   1920

ggtattgcct tggctctatt tggcatggat ggagcccagt tggaaaattc ccaaatatta   1980

caacaagtcc ttgaacccag gccatgtggt tagacgttgg tgttaaggtt agaccttatg   2040

ttagagtcat ttctgatgtt ccagcttcta gccatgtagt gctctcagtc ttcatacccc   2100

agaaattatt ggtatatttg tagataccga gaatgatccc tcagtctgag aggttagaat   2160

gatcatctgt aatctgaggg ttaatttcta ggcaggtgga gagagtggta aaaaagaaat   2220

gaaattgaca agctaggaaa gaggaggcag aaagatttgg aaaattcaca gagtttcacc   2280

cttaagctgt agagagtggg tcacatttgt tagccacgga aacatagaaa catacacaag   2340

gccagaaaaa gaagaaggag ctcaactaaa agtggcatag agaatacaca tataaaaaca   2400

atatatttgt catatgctcc tagagaggag aaaggggtga ttgaaagaaa aaaaaatact   2460

taaatatttg taattgtgag gggtttcttt tggaaataat tacttttgaa ccatgtatgt   2520

ggtatgtata ttttcagtgg gttaattata ccccatgata cctattaaag gaaaaccagt   2580

gggtctggtg gtgctggtct tttcctcccc attcctacaa tttctatgtg gcccaagtca   2640

ttcctaatct tggtctctat agcagtgttc tctctgaatg ctgagctgaa gaaattatac   2700

gtacatacac acatacatac atacatacaa atatatgtat atatattctc agctgctgcg   2760

ggaggtaggt accatggcca ttcagcacag ccttgatttc ctcccaaagt aggtgagcta   2820

tagtgaagaa taggtgcaaa caaacaagct tacttccatt gcaaaataga agaagaggaa   2880

gttagagata attctgatca atcattttgg aggctttgtt ataaggcaac ccccggtata   2940

tcatggaatt tccattgaca tttgaatttg gacttggatc ttcccttggt cccattagct   3000

gaggtttagt aatctaaagt ccctatagta tatgattata atgctatttt aaaaaatata   3060

tatataaaat atttttttct ttttaaaata gacactatag ttttacccat aagtaatatt   3120

taaagattat agctcccaaa agaatggacc aaccactttc gtatcataat ttctttttgg   3180

taaatatgag actattatga aatcatagta tatgattgta tttaaaggta caatcaaagg   3240

atcttttgtc cattccatta ataactgaat aaaaaataaa taaaatggat agaaaaaaac   3300

taaagttgaa aatacattct taaactagtt gtctgaattg agaaaagagt gagaactagg   3360

tgtgcaagaa ccaaacgtat tttattttat tttttaaatg ggagcaacat atcagtcgtg   3420

tcaccagctg gtatattgtg taaatattaa agctccattg ggactgattt ttcatggcaa   3480

catcagcttt ctaatgttct aaattctata aaaaccaccc acaaagaaac aaagcaaatt   3540

tcattatcta atgagttgct ggaaaatcat attgagaata attatttcag attcctcagt   3600

tgttaacttc tacattcaag gcttatctct gcccccattg atttttaacc tcaaaatggt   3660

gttgagattt acgtggaacc ctaaagcagt aaaataaaaa acctggttgc agcacattca   3720

cactgttgtc cttaaaattc cccttttttc tctatgtacg ataaagtaac agtatgtcag   3780

ataagccggt ggggggatga gattaggctg aggcagtgct agtcaactgg ggaaaaggat   3840

gatggaaaaa tcacccagtt gtgctatatt tttaaagaag gaggtcgttt atgtgtgcag   3900

acaattctcc ctgaggttag cccaatggag aaatgaagca gaggaaggaa acatagaaag   3960

acatgggcta tcagggagga agatgttcaa tagaacatgc aagaatttct ggaagaaagg   4020

ctgtggaagg gccaatggag aaaatgaatg gacaaagctc aggaatccta cgctatgtag   4080

aatgtcttgg tgttatcagg gttaagcctg taattatgta acctatttat cgcaacatga   4140

atttttatga tttcttgtga tgtattcttt tatgaaatta acaagaactc attattttga   4200

ggtagaggaa aatcaatgct ttatctgata tgctgagaaa ttattagatt gccaatactc   4260

atgtgcgttt catgtgtttt ataaggtttg ttcctttgaa gaattgtagt tcttagtccc   4320

acagggaaat gtgtatctat ttatatatca tagtataaat ctatgatata tttatatcat   4380

atataaaagt ctgagttctc tttcttagtc cctaatcatg tttctcccat aggctgtgtt   4440

tacatggagc tatcggttta gccttttaag cttcattagc ttgtctatta ttgaaatagt   4500

ttccaagaaa ttttagatat tatcataaca tctgggtcta ctcaaacact tattgtttga   4560

aagacttatg tcttggacct atcaaaaact gactttattt attgcttagt gaaaatacta   4620

gtgggatcaa caatgatttt cttgaatggg catgaatgga gatgcccgca cagtaatgta   4680

gaaatgtttc atacagctat taaaatgtaa ctgacctcct tagaggcaga ttagtaactg   4740

ttcctacttt gtatagctaa gtgacagtca cttaacttac atgactttct tttttcacat   4800

tgggtctctg gtcctgtgtc ttcacctcat ttatagcacg tctccttgat ttttggtagt   4860

atcaacttcc cagtgatctg ttcagttaag ttcttctccc gttaaccagg aagtgcttat   4920

tctctcatca cagtgggaag aatagcctat tgtctttcat tttgcctgag tgtattttac   4980

tatttgggct ctgaaataaa aattatgaaa tatggtgagg tcacatgttg gtgctgcctt   5040

gctgcataaa attctagagg gcaggttaga gacagtatgt atgccttcgg gaaaattcaa   5100

aggtggatta caaggtgtcc tcagcatgcc ctatggccta tgtgcgaagc aagaagaatt   5160

gactgattta caggacttct ctttatgtca atcttaagag gatggatgaa tctggacatt   5220

tgttccaccc gacctctgac tgatggtttg gaaaataact ttaattagga tcatatgacc   5280

attgaaaaag gaaaaatgta gactctgact tccgtcccac tgaaggatta atgaaaacct   5340

ttactagcat ttagagcttt tcagaacatc cccactgtca tgtgtctcag cagtggagac   5400

tgcaagtaag gcttttaatt ttaggaggtt tttttttttt tttttttttc cctaaatggt   5460

atggccaaaa gtcagagtta aaatatatat agttagattc caacttcctc cttcactcta   5520

aaaatagaat ccaaacccac tcttcatata tgcttccaga atggggctta agtaccaatc   5580

tctgctttgc aatgggcaca atcttggtca tgtcctgagg ctctctaaga aaagagagga   5640

tctaggatgg gagagctaga aagttgctaa ctgggaagaa caaggccctg agggcttggt   5700

ctaccaatct gggaagattt gaaaacaaac ttctcgcaac tgaaggaagg ctgaaggctg   5760

ctgcaagtca ttgagtgact ttaggatgag caaaacattg ggccacttcc taatgcccta   5820

tgtgtatagt accagaagca aggtctcaga cttaacagac ccagctctgt tccaaggtga   5880

gtctgaacca atagaaagca aacatgtgca gatatccaaa caagactgct catgcaagtc   5940

ggggctggct acccgtctta ggcagcaaca gcagagctcc agggagctta ttcaatattt   6000

actgagactt cgaagaccca gcagatgttt aatgaagtca ctattttggc tcaaaccctc   6060

cacttctccc cctcccctca aaaagccaac aggtaaacac ataaatgaaa gaaacccaca   6120

gaaggggatg ggaaataaag aaaattctct caagacttct ccaggcccat gtcactggtc   6180

agcgtggttt ttatgtgtat taggattggg ggatgtgaag aaataagtat ccagtacttt   6240

ataaccaaag caattaaatg atattgggta gggaatgttg gccagttttg tttagttttg   6300

catcacattg tcaccagact cactagccca agtaatcggg cgcccgaaga gggagacaga   6360

gatgtgcaga gttgaccagt gtgcggatga taactactga cgaaagagtc atcgactcag   6420

ttagtggttg gatgtagtca cattagtttg cctctcccca tctttgtctc cctggcaagg   6480

agaatatgcg ggacatgatg ctaagagtcc tgggtaaatg tggtgagaat gcacgcgtgc   6540

atatgctaca catatgtgct tctcagttgc agaaaatgaa ctgctttggg agattatcag   6600

tagaaagagt gttatcatat tggtgctgag tgctatgtgt gcttatacaa tttgttcttg   6660

tattttaata aactttgaat aaaagaat                                      6688


<210>  2
<211>  273
<212>  PRT
<213>  human

<400>  2

Met Gly Ile Leu Ser Val Asp Leu Leu Ile Thr Leu Gln Ile Leu Pro 
1               5                   10                  15      


Val Phe Phe Ser Asn Cys Leu Phe Leu Ala Leu Tyr Asp Ser Val Ile 
            20                  25                  30          


Leu Leu Lys His Val Val Leu Leu Leu Ser Arg Ser Lys Ser Thr Arg 
        35                  40                  45              


Gly Glu Trp Arg Arg Met Leu Thr Ser Glu Gly Leu Arg Cys Val Trp 
    50                  55                  60                  


Lys Ser Phe Leu Leu Asp Ala Tyr Lys Gln Val Lys Leu Gly Glu Asp 
65                  70                  75                  80  


Ala Pro Asn Ser Ser Val Val His Val Ser Ser Ala Glu Gly Gly Asp 
                85                  90                  95      


Asn Ser Gly Asn Gly Thr Gln Glu Lys Ile Ala Glu Gly Ala Thr Cys 
            100                 105                 110         


His Leu Leu Asp Phe Ala Ser Pro Glu Arg Pro Leu Val Val Asn Phe 
        115                 120                 125             


Gly Ser Ala Thr Cys Pro Pro Phe Thr Ser Gln Leu Pro Ala Phe Arg 
    130                 135                 140                 


Lys Leu Val Glu Glu Phe Ser Ser Val Ala Asp Phe Leu Leu Val Tyr 
145                 150                 155                 160 


Ile Asp Glu Ala His Pro Ser Asp Gly Trp Ala Ile Pro Gly Asp Ser 
                165                 170                 175     


Ser Leu Ser Phe Glu Val Lys Lys His Gln Asn Gln Glu Asp Arg Cys 
            180                 185                 190         


Ala Ala Ala Gln Gln Leu Leu Glu Arg Phe Ser Leu Pro Pro Gln Cys 
        195                 200                 205             


Arg Val Val Ala Asp Arg Met Asp Asn Asn Ala Asn Ile Ala Tyr Gly 
    210                 215                 220                 


Val Ala Phe Glu Arg Val Cys Ile Val Gln Arg Gln Lys Ile Ala Tyr 
225                 230                 235                 240 


Leu Gly Gly Lys Gly Pro Phe Ser Tyr Asn Leu Gln Glu Val Arg His 
                245                 250                 255     


Trp Leu Glu Lys Asn Phe Ser Lys Arg Cys Lys Lys Thr Arg Leu Ala 
            260                 265                 270         


Gly 
    


<210>  3
<211>  6688
<212>  DNA
<213>  human

<400>  3
ggctgcagag agaggcactt tgcaccacag acagatagca agaagggaaa gacagagagt     60

gagaaaaaag aggagtcagt cgctcctggg gaagggagag agtgagactg ggagaaagag    120

aagcacagaa agtgtgtgta aaacggagta aagaaagaaa aaaaaaaaac tacccttaaa    180

gcacatttaa aaaaaaaaaa aactctggca attcaagaaa gaaacaggct acgtttaaag    240

agcatagaga caatgaaagg ctaaagaaaa ttttaaaatc tctgccacag tctcataggt    300

gcttggaaat gaaagtagaa ctgcctgtct ttaacggact ctgacagagg taactggatt    360

agggacgagt acgccagctt tttttttttt tttttttttt tttttttaac atcttaaatc    420

ctgaaaaaaa aaaaaaaaaa aaaaaaaagg cagcagctcc gaattgaatg aattgatggg    480

cacactccaa ctgctgggct ggagagactg gacttagtct tgccatttct gcttctttga    540

aagaggagac aacttgggct tccttttaat ttagtttttt ttccccttct cccccaaccc    600

ccaaccttcc cccttacctc ccccaccccc tttatcacca cccccctttt aaataagagg    660

gtgaagggga accagagcgc acaagggaac tgactcagga ggcagagaag atgggcatcc    720

tcagcgtaga cttgctgatc acactgcaaa ttctgccagt ttttttctcc aactgcctct    780

tcctggctct ctatgactcg gtcattctgc tcaagcacgt ggtgctgctg ttgagccgct    840

ccaagtccac tcgcggagag tggcggcgca tgctgacctc agagggactg cgctgcgtct    900

ggaagagctt cctcctcgat gcctacaaac aggtgaaatt gggtgaggat gcccccaatt    960

ccagtgtggt gcatgtctcc agtacagaag gaggtgacaa cagtggcaat ggtacccagg   1020

agaagatagc tgagggagcc acatgccacc ttcttgactt tgccagccct gagcgcccac   1080

tagtggtcaa ctttggctca gccacttgac ctcctttcac gagccagctg ccagccttcc   1140

gcaaactggt ggaagagttc tcctcagtgg ctgacttcct gctggtctac attgatgagg   1200

ctcatccatc agatggctgg gcgataccgg gggactcctc tttgtctttt gaggtgaaga   1260

agcaccagaa ccaggaagat cgatgtgcag cagcccagca gcttctggag cgtttctcct   1320

tgccgcccca gtgccgagtt gtggctgacc gcatggacaa taacgccaac atagcttacg   1380

gggtagcctt tgaacgtgtg tgcattgtgc agagacagaa aattgcttat ctgggaggaa   1440

agggcccctt ctcctacaac cttcaagaag tccggcattg gctggagaag aatttcagca   1500

agagatgaaa gaaaactaga ttagctggtt aaaggtatga ttataagaga gcttattgtt   1560

ttaaaaagtt atataaaggc aaggaaatta agaactgaat ccatatttca acagagccct   1620

attggcttac tgaaagacag gagtttatct atcggaagaa catgaatctc taacagctcc   1680

atacttcttt cactactcaa atggcattgg gctgagtaag taaccatatc acctctcttc   1740

ttagtaaaaa gccctatgtg aaaagatccc aagatggaga ggaagaaacg ctaattcagc   1800

atgtgttcat tctgcattga gaaggaactg atacatctga tgcatgcttt gagaccagaa   1860

gaaaagactt acctgaataa ttactacatt agggaagcta ctgtctacgt taagataaag   1920

ggtattgcct tggctctatt tggcatggat ggagcccagt tggaaaattc ccaaatatta   1980

caacaagtcc ttgaacccag gccatgtggt tagacgttgg tgttaaggtt agaccttatg   2040

ttagagtcat ttctgatgtt ccagcttcta gccatgtagt gctctcagtc ttcatacccc   2100

agaaattatt ggtatatttg tagataccga gaatgatccc tcagtctgag aggttagaat   2160

gatcatctgt aatctgaggg ttaatttcta ggcaggtgga gagagtggta aaaaagaaat   2220

gaaattgaca agctaggaaa gaggaggcag aaagatttgg aaaattcaca gagtttcacc   2280

cttaagctgt agagagtggg tcacatttgt tagccacgga aacatagaaa catacacaag   2340

gccagaaaaa gaagaaggag ctcaactaaa agtggcatag agaatacaca tataaaaaca   2400

atatatttgt catatgctcc tagagaggag aaaggggtga ttgaaagaaa aaaaaatact   2460

taaatatttg taattgtgag gggtttcttt tggaaataat tacttttgaa ccatgtatgt   2520

ggtatgtata ttttcagtgg gttaattata ccccatgata cctattaaag gaaaaccagt   2580

gggtctggtg gtgctggtct tttcctcccc attcctacaa tttctatgtg gcccaagtca   2640

ttcctaatct tggtctctat agcagtgttc tctctgaatg ctgagctgaa gaaattatac   2700

gtacatacac acatacatac atacatacaa atatatgtat atatattctc agctgctgcg   2760

ggaggtaggt accatggcca ttcagcacag ccttgatttc ctcccaaagt aggtgagcta   2820

tagtgaagaa taggtgcaaa caaacaagct tacttccatt gcaaaataga agaagaggaa   2880

gttagagata attctgatca atcattttgg aggctttgtt ataaggcaac ccccggtata   2940

tcatggaatt tccattgaca tttgaatttg gacttggatc ttcccttggt cccattagct   3000

gaggtttagt aatctaaagt ccctatagta tatgattata atgctatttt aaaaaatata   3060

tatataaaat atttttttct ttttaaaata gacactatag ttttacccat aagtaatatt   3120

taaagattat agctcccaaa agaatggacc aaccactttc gtatcataat ttctttttgg   3180

taaatatgag actattatga aatcatagta tatgattgta tttaaaggta caatcaaagg   3240

atcttttgtc cattccatta ataactgaat aaaaaataaa taaaatggat agaaaaaaac   3300

taaagttgaa aatacattct taaactagtt gtctgaattg agaaaagagt gagaactagg   3360

tgtgcaagaa ccaaacgtat tttattttat tttttaaatg ggagcaacat atcagtcgtg   3420

tcaccagctg gtatattgtg taaatattaa agctccattg ggactgattt ttcatggcaa   3480

catcagcttt ctaatgttct aaattctata aaaaccaccc acaaagaaac aaagcaaatt   3540

tcattatcta atgagttgct ggaaaatcat attgagaata attatttcag attcctcagt   3600

tgttaacttc tacattcaag gcttatctct gcccccattg atttttaacc tcaaaatggt   3660

gttgagattt acgtggaacc ctaaagcagt aaaataaaaa acctggttgc agcacattca   3720

cactgttgtc cttaaaattc cccttttttc tctatgtacg ataaagtaac agtatgtcag   3780

ataagccggt ggggggatga gattaggctg aggcagtgct agtcaactgg ggaaaaggat   3840

gatggaaaaa tcacccagtt gtgctatatt tttaaagaag gaggtcgttt atgtgtgcag   3900

acaattctcc ctgaggttag cccaatggag aaatgaagca gaggaaggaa acatagaaag   3960

acatgggcta tcagggagga agatgttcaa tagaacatgc aagaatttct ggaagaaagg   4020

ctgtggaagg gccaatggag aaaatgaatg gacaaagctc aggaatccta cgctatgtag   4080

aatgtcttgg tgttatcagg gttaagcctg taattatgta acctatttat cgcaacatga   4140

atttttatga tttcttgtga tgtattcttt tatgaaatta acaagaactc attattttga   4200

ggtagaggaa aatcaatgct ttatctgata tgctgagaaa ttattagatt gccaatactc   4260

atgtgcgttt catgtgtttt ataaggtttg ttcctttgaa gaattgtagt tcttagtccc   4320

acagggaaat gtgtatctat ttatatatca tagtataaat ctatgatata tttatatcat   4380

atataaaagt ctgagttctc tttcttagtc cctaatcatg tttctcccat aggctgtgtt   4440

tacatggagc tatcggttta gccttttaag cttcattagc ttgtctatta ttgaaatagt   4500

ttccaagaaa ttttagatat tatcataaca tctgggtcta ctcaaacact tattgtttga   4560

aagacttatg tcttggacct atcaaaaact gactttattt attgcttagt gaaaatacta   4620

gtgggatcaa caatgatttt cttgaatggg catgaatgga gatgcccgca cagtaatgta   4680

gaaatgtttc atacagctat taaaatgtaa ctgacctcct tagaggcaga ttagtaactg   4740

ttcctacttt gtatagctaa gtgacagtca cttaacttac atgactttct tttttcacat   4800

tgggtctctg gtcctgtgtc ttcacctcat ttatagcacg tctccttgat ttttggtagt   4860

atcaacttcc cagtgatctg ttcagttaag ttcttctccc gttaaccagg aagtgcttat   4920

tctctcatca cagtgggaag aatagcctat tgtctttcat tttgcctgag tgtattttac   4980

tatttgggct ctgaaataaa aattatgaaa tatggtgagg tcacatgttg gtgctgcctt   5040

gctgcataaa attctagagg gcaggttaga gacagtatgt atgccttcgg gaaaattcaa   5100

aggtggatta caaggtgtcc tcagcatgcc ctatggccta tgtgcgaagc aagaagaatt   5160

gactgattta caggacttct ctttatgtca atcttaagag gatggatgaa tctggacatt   5220

tgttccaccc gacctctgac tgatggtttg gaaaataact ttaattagga tcatatgacc   5280

attgaaaaag gaaaaatgta gactctgact tccgtcccac tgaaggatta atgaaaacct   5340

ttactagcat ttagagcttt tcagaacatc cccactgtca tgtgtctcag cagtggagac   5400

tgcaagtaag gcttttaatt ttaggaggtt tttttttttt tttttttttc cctaaatggt   5460

atggccaaaa gtcagagtta aaatatatat agttagattc caacttcctc cttcactcta   5520

aaaatagaat ccaaacccac tcttcatata tgcttccaga atggggctta agtaccaatc   5580

tctgctttgc aatgggcaca atcttggtca tgtcctgagg ctctctaaga aaagagagga   5640

tctaggatgg gagagctaga aagttgctaa ctgggaagaa caaggccctg agggcttggt   5700

ctaccaatct gggaagattt gaaaacaaac ttctcgcaac tgaaggaagg ctgaaggctg   5760

ctgcaagtca ttgagtgact ttaggatgag caaaacattg ggccacttcc taatgcccta   5820

tgtgtatagt accagaagca aggtctcaga cttaacagac ccagctctgt tccaaggtga   5880

gtctgaacca atagaaagca aacatgtgca gatatccaaa caagactgct catgcaagtc   5940

ggggctggct acccgtctta ggcagcaaca gcagagctcc agggagctta ttcaatattt   6000

actgagactt cgaagaccca gcagatgttt aatgaagtca ctattttggc tcaaaccctc   6060

cacttctccc cctcccctca aaaagccaac aggtaaacac ataaatgaaa gaaacccaca   6120

gaaggggatg ggaaataaag aaaattctct caagacttct ccaggcccat gtcactggtc   6180

agcgtggttt ttatgtgtat taggattggg ggatgtgaag aaataagtat ccagtacttt   6240

ataaccaaag caattaaatg atattgggta gggaatgttg gccagttttg tttagttttg   6300

catcacattg tcaccagact cactagccca agtaatcggg cgcccgaaga gggagacaga   6360

gatgtgcaga gttgaccagt gtgcggatga taactactga cgaaagagtc atcgactcag   6420

ttagtggttg gatgtagtca cattagtttg cctctcccca tctttgtctc cctggcaagg   6480

agaatatgcg ggacatgatg ctaagagtcc tgggtaaatg tggtgagaat gcacgcgtgc   6540

atatgctaca catatgtgct tctcagttgc agaaaatgaa ctgctttggg agattatcag   6600

tagaaagagt gttatcatat tggtgctgag tgctatgtgt gcttatacaa tttgttcttg   6660

tattttaata aactttgaat aaaagaat                                      6688


<210>  4
<211>  273
<212>  PRT
<213>  human

<400>  4

Met Gly Ile Leu Ser Val Asp Leu Leu Ile Thr Leu Gln Ile Leu Pro 
1               5                   10                  15      


Val Phe Phe Ser Asn Cys Leu Phe Leu Ala Leu Tyr Asp Ser Val Ile 
            20                  25                  30          


Leu Leu Lys His Val Val Leu Leu Leu Ser Arg Ser Lys Ser Thr Arg 
        35                  40                  45              


Gly Glu Trp Arg Arg Met Leu Thr Ser Glu Gly Leu Arg Cys Val Trp 
    50                  55                  60                  


Lys Ser Phe Leu Leu Asp Ala Tyr Lys Gln Val Lys Leu Gly Glu Asp 
65                  70                  75                  80  


Ala Pro Asn Ser Ser Val Val His Val Ser Ser Thr Glu Gly Gly Asp 
                85                  90                  95      


Asn Ser Gly Asn Gly Thr Gln Glu Lys Ile Ala Glu Gly Ala Thr Cys 
            100                 105                 110         


His Leu Leu Asp Phe Ala Ser Pro Glu Arg Pro Leu Val Val Asn Phe 
        115                 120                 125             


Gly Ser Ala Thr Cys Pro Pro Phe Thr Ser Gln Leu Pro Ala Phe Arg 
    130                 135                 140                 


Lys Leu Val Glu Glu Phe Ser Ser Val Ala Asp Phe Leu Leu Val Tyr 
145                 150                 155                 160 


Ile Asp Glu Ala His Pro Ser Asp Gly Trp Ala Ile Pro Gly Asp Ser 
                165                 170                 175     


Ser Leu Ser Phe Glu Val Lys Lys His Gln Asn Gln Glu Asp Arg Cys 
            180                 185                 190         


Ala Ala Ala Gln Gln Leu Leu Glu Arg Phe Ser Leu Pro Pro Gln Cys 
        195                 200                 205             


Arg Val Val Ala Asp Arg Met Asp Asn Asn Ala Asn Ile Ala Tyr Gly 
    210                 215                 220                 


Val Ala Phe Glu Arg Val Cys Ile Val Gln Arg Gln Lys Ile Ala Tyr 
225                 230                 235                 240 


Leu Gly Gly Lys Gly Pro Phe Ser Tyr Asn Leu Gln Glu Val Arg His 
                245                 250                 255     


Trp Leu Glu Lys Asn Phe Ser Lys Arg Cys Lys Lys Thr Arg Leu Ala 
            260                 265                 270         


Gly 
    


