                         SEQUENCE LISTING

<110>  Plamtechno S.r.l.
 
<120>  Apo A-1 Muteins

<130>  BI3770R

<160>  54    

<170>  PatentIn version 3.3

<210>  1
<211>  732
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(732)
<223>  Mutein of Human Apo A-1  R173C: Apo A-1 Milano

<400>  1
gat gaa ccc ccc cag agc ccc tgg gat cga gtg aag gac ctg gcc act       48
Asp Glu Pro Pro Gln Ser Pro Trp Asp Arg Val Lys Asp Leu Ala Thr         
1               5                   10                  15              

gtg tac gtg gat gtg ctc aaa gac agc ggc aga gac tat gtg tcc cag       96
Val Tyr Val Asp Val Leu Lys Asp Ser Gly Arg Asp Tyr Val Ser Gln         
            20                  25                  30                  

ttt gaa ggc tcc gcc ttg gga aaa cag cta aac cta aag ctc ctt gac      144
Phe Glu Gly Ser Ala Leu Gly Lys Gln Leu Asn Leu Lys Leu Leu Asp         
        35                  40                  45                      

aac tgg gac agc gtg acc tcc acc ttc agc aag ctg cgc gaa cag ctc      192
Asn Trp Asp Ser Val Thr Ser Thr Phe Ser Lys Leu Arg Glu Gln Leu         
    50                  55                  60                          

ggc cct gtg acc cag gag ttc tgg gat aac ctg gaa aag gag aca gag      240
Gly Pro Val Thr Gln Glu Phe Trp Asp Asn Leu Glu Lys Glu Thr Glu         
65                  70                  75                  80          

ggc ctg agg caa gag atg agc aag gat ctg gag gag gtg aag gcc aag      288
Gly Leu Arg Gln Glu Met Ser Lys Asp Leu Glu Glu Val Lys Ala Lys         
                85                  90                  95              

gtg cag ccc tac ctg gac gac ttc cag aag aag tgg cag gag gag atg      336
Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu Met         
            100                 105                 110                 

gag ctc tac cgc cag aag gtg gag ccg ctg cgc gca gag ctc caa gag      384
Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu Arg Ala Glu Leu Gln Glu         
        115                 120                 125                     

ggc gcg cgc cag aag ctg cac gag ctg caa gag aag ctg agc cca ctg      432
Gly Ala Arg Gln Lys Leu His Glu Leu Gln Glu Lys Leu Ser Pro Leu         
    130                 135                 140                         

ggc gag gag atg cgc gac cgc gcg cgc gcc cat gtg gac gcg ctg cgc      480
Gly Glu Glu Met Arg Asp Arg Ala Arg Ala His Val Asp Ala Leu Arg         
145                 150                 155                 160         

acg cat ctg gcc ccc tac agc gac gag ctg cgc cag tgc ttg gcc gcg      528
Thr His Leu Ala Pro Tyr Ser Asp Glu Leu Arg Gln Cys Leu Ala Ala         
                165                 170                 175             

cgc ctt gag gct ctc aag gag aac ggc ggc gcc aga ctg gcc gag tac      576
Arg Leu Glu Ala Leu Lys Glu Asn Gly Gly Ala Arg Leu Ala Glu Tyr         
            180                 185                 190                 

cac gcc aag gcc acc gag cat ctg agc acg ctc agc gag aag gcc aag      624
His Ala Lys Ala Thr Glu His Leu Ser Thr Leu Ser Glu Lys Ala Lys         
        195                 200                 205                     

ccc gcg ctc gag gac ctc cgc caa ggc ctg ctg ccc gtg ctg gag agc      672
Pro Ala Leu Glu Asp Leu Arg Gln Gly Leu Leu Pro Val Leu Glu Ser         
    210                 215                 220                         

ttc aag gtc agc ttc ctg agc gct ctc gag gag tac act aag aag ctc      720
Phe Lys Val Ser Phe Leu Ser Ala Leu Glu Glu Tyr Thr Lys Lys Leu         
225                 230                 235                 240         

aac acc cag tga                                                      732
Asn Thr Gln                                                             
                                                                        


<210>  2
<211>  243
<212>  PRT
<213>  Homo sapiens

<400>  2

Asp Glu Pro Pro Gln Ser Pro Trp Asp Arg Val Lys Asp Leu Ala Thr 
1               5                   10                  15      


Val Tyr Val Asp Val Leu Lys Asp Ser Gly Arg Asp Tyr Val Ser Gln 
            20                  25                  30          


Phe Glu Gly Ser Ala Leu Gly Lys Gln Leu Asn Leu Lys Leu Leu Asp 
        35                  40                  45              


Asn Trp Asp Ser Val Thr Ser Thr Phe Ser Lys Leu Arg Glu Gln Leu 
    50                  55                  60                  


Gly Pro Val Thr Gln Glu Phe Trp Asp Asn Leu Glu Lys Glu Thr Glu 
65                  70                  75                  80  


Gly Leu Arg Gln Glu Met Ser Lys Asp Leu Glu Glu Val Lys Ala Lys 
                85                  90                  95      


Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu Met 
            100                 105                 110         


Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu Arg Ala Glu Leu Gln Glu 
        115                 120                 125             


Gly Ala Arg Gln Lys Leu His Glu Leu Gln Glu Lys Leu Ser Pro Leu 
    130                 135                 140                 


Gly Glu Glu Met Arg Asp Arg Ala Arg Ala His Val Asp Ala Leu Arg 
145                 150                 155                 160 


Thr His Leu Ala Pro Tyr Ser Asp Glu Leu Arg Gln Cys Leu Ala Ala 
                165                 170                 175     


Arg Leu Glu Ala Leu Lys Glu Asn Gly Gly Ala Arg Leu Ala Glu Tyr 
            180                 185                 190         


His Ala Lys Ala Thr Glu His Leu Ser Thr Leu Ser Glu Lys Ala Lys 
        195                 200                 205             


Pro Ala Leu Glu Asp Leu Arg Gln Gly Leu Leu Pro Val Leu Glu Ser 
    210                 215                 220                 


Phe Lys Val Ser Phe Leu Ser Ala Leu Glu Glu Tyr Thr Lys Lys Leu 
225                 230                 235                 240 


Asn Thr Gln 
            


<210>  3
<211>  732
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(732)
<223>  Mutein of human Apo A-1 

R123C

<400>  3
gat gaa ccc ccc cag agc ccc tgg gat cga gtg aag gac ctg gcc act       48
Asp Glu Pro Pro Gln Ser Pro Trp Asp Arg Val Lys Asp Leu Ala Thr         
1               5                   10                  15              

gtg tac gtg gat gtg ctc aaa gac agc ggc aga gac tat gtg tcc cag       96
Val Tyr Val Asp Val Leu Lys Asp Ser Gly Arg Asp Tyr Val Ser Gln         
            20                  25                  30                  

ttt gaa ggc tcc gcc ttg gga aaa cag cta aac cta aag ctc ctt gac      144
Phe Glu Gly Ser Ala Leu Gly Lys Gln Leu Asn Leu Lys Leu Leu Asp         
        35                  40                  45                      

aac tgg gac agc gtg acc tcc acc ttc agc aag ctg cgc gaa cag ctc      192
Asn Trp Asp Ser Val Thr Ser Thr Phe Ser Lys Leu Arg Glu Gln Leu         
    50                  55                  60                          

ggc cct gtg acc cag gag ttc tgg gat aac ctg gaa aag gag aca gag      240
Gly Pro Val Thr Gln Glu Phe Trp Asp Asn Leu Glu Lys Glu Thr Glu         
65                  70                  75                  80          

ggc ctg agg caa gag atg agc aag gat ctg gag gag gtg aag gcc aag      288
Gly Leu Arg Gln Glu Met Ser Lys Asp Leu Glu Glu Val Lys Ala Lys         
                85                  90                  95              

gtg cag ccc tac ctg gac gac ttc cag aag aag tgg cag gag gag atg      336
Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu Met         
            100                 105                 110                 

gag ctc tac cgc cag aag gtg gag ccg ctg tgc gca gag ctc caa gag      384
Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu Cys Ala Glu Leu Gln Glu         
        115                 120                 125                     

ggc gcg cgc cag aag ctg cac gag ctg caa gag aag ctg agc cca ctg      432
Gly Ala Arg Gln Lys Leu His Glu Leu Gln Glu Lys Leu Ser Pro Leu         
    130                 135                 140                         

ggc gag gag atg cgc gac cgc gcg cgc gcc cat gtg gac gcg ctg cgc      480
Gly Glu Glu Met Arg Asp Arg Ala Arg Ala His Val Asp Ala Leu Arg         
145                 150                 155                 160         

acg cat ctg gcc ccc tac agc gac gag ctg cgc cag cgc ttg gcc gcg      528
Thr His Leu Ala Pro Tyr Ser Asp Glu Leu Arg Gln Arg Leu Ala Ala         
                165                 170                 175             

cgc ctt gag gct ctc aag gag aac ggc ggc gcc aga ctg gcc gag tac      576
Arg Leu Glu Ala Leu Lys Glu Asn Gly Gly Ala Arg Leu Ala Glu Tyr         
            180                 185                 190                 

cac gcc aag gcc acc gag cat ctg agc acg ctc agc gag aag gcc aag      624
His Ala Lys Ala Thr Glu His Leu Ser Thr Leu Ser Glu Lys Ala Lys         
        195                 200                 205                     

ccc gcg ctc gag gac ctc cgc caa ggc ctg ctg ccc gtg ctg gag agc      672
Pro Ala Leu Glu Asp Leu Arg Gln Gly Leu Leu Pro Val Leu Glu Ser         
    210                 215                 220                         

ttc aag gtc agc ttc ctg agc gct ctc gag gag tac act aag aag ctc      720
Phe Lys Val Ser Phe Leu Ser Ala Leu Glu Glu Tyr Thr Lys Lys Leu         
225                 230                 235                 240         

aac acc cag tga                                                      732
Asn Thr Gln                                                             
                                                                        


<210>  4
<211>  243
<212>  PRT
<213>  Homo sapiens

<400>  4

Asp Glu Pro Pro Gln Ser Pro Trp Asp Arg Val Lys Asp Leu Ala Thr 
1               5                   10                  15      


Val Tyr Val Asp Val Leu Lys Asp Ser Gly Arg Asp Tyr Val Ser Gln 
            20                  25                  30          


Phe Glu Gly Ser Ala Leu Gly Lys Gln Leu Asn Leu Lys Leu Leu Asp 
        35                  40                  45              


Asn Trp Asp Ser Val Thr Ser Thr Phe Ser Lys Leu Arg Glu Gln Leu 
    50                  55                  60                  


Gly Pro Val Thr Gln Glu Phe Trp Asp Asn Leu Glu Lys Glu Thr Glu 
65                  70                  75                  80  


Gly Leu Arg Gln Glu Met Ser Lys Asp Leu Glu Glu Val Lys Ala Lys 
                85                  90                  95      


Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu Met 
            100                 105                 110         


Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu Cys Ala Glu Leu Gln Glu 
        115                 120                 125             


Gly Ala Arg Gln Lys Leu His Glu Leu Gln Glu Lys Leu Ser Pro Leu 
    130                 135                 140                 


Gly Glu Glu Met Arg Asp Arg Ala Arg Ala His Val Asp Ala Leu Arg 
145                 150                 155                 160 


Thr His Leu Ala Pro Tyr Ser Asp Glu Leu Arg Gln Arg Leu Ala Ala 
                165                 170                 175     


Arg Leu Glu Ala Leu Lys Glu Asn Gly Gly Ala Arg Leu Ala Glu Tyr 
            180                 185                 190         


His Ala Lys Ala Thr Glu His Leu Ser Thr Leu Ser Glu Lys Ala Lys 
        195                 200                 205             


Pro Ala Leu Glu Asp Leu Arg Gln Gly Leu Leu Pro Val Leu Glu Ser 
    210                 215                 220                 


Phe Lys Val Ser Phe Leu Ser Ala Leu Glu Glu Tyr Thr Lys Lys Leu 
225                 230                 235                 240 


Asn Thr Gln 
            


<210>  5
<211>  732
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(732)
<223>  Mutein of human Apo A-1 

R215C

<400>  5
gat gaa ccc ccc cag agc ccc tgg gat cga gtg aag gac ctg gcc act       48
Asp Glu Pro Pro Gln Ser Pro Trp Asp Arg Val Lys Asp Leu Ala Thr         
1               5                   10                  15              

gtg tac gtg gat gtg ctc aaa gac agc ggc aga gac tat gtg tcc cag       96
Val Tyr Val Asp Val Leu Lys Asp Ser Gly Arg Asp Tyr Val Ser Gln         
            20                  25                  30                  

ttt gaa ggc tcc gcc ttg gga aaa cag cta aac cta aag ctc ctt gac      144
Phe Glu Gly Ser Ala Leu Gly Lys Gln Leu Asn Leu Lys Leu Leu Asp         
        35                  40                  45                      

aac tgg gac agc gtg acc tcc acc ttc agc aag ctg cgc gaa cag ctc      192
Asn Trp Asp Ser Val Thr Ser Thr Phe Ser Lys Leu Arg Glu Gln Leu         
    50                  55                  60                          

ggc cct gtg acc cag gag ttc tgg gat aac ctg gaa aag gag aca gag      240
Gly Pro Val Thr Gln Glu Phe Trp Asp Asn Leu Glu Lys Glu Thr Glu         
65                  70                  75                  80          

ggc ctg agg caa gag atg agc aag gat ctg gag gag gtg aag gcc aag      288
Gly Leu Arg Gln Glu Met Ser Lys Asp Leu Glu Glu Val Lys Ala Lys         
                85                  90                  95              

gtg cag ccc tac ctg gac gac ttc cag aag aag tgg cag gag gag atg      336
Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu Met         
            100                 105                 110                 

gag ctc tac cgc cag aag gtg gag ccg ctg cgc gca gag ctc caa gag      384
Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu Arg Ala Glu Leu Gln Glu         
        115                 120                 125                     

ggc gcg cgc cag aag ctg cac gag ctg caa gag aag ctg agc cca ctg      432
Gly Ala Arg Gln Lys Leu His Glu Leu Gln Glu Lys Leu Ser Pro Leu         
    130                 135                 140                         

ggc gag gag atg cgc gac cgc gcg cgc gcc cat gtg gac gcg ctg cgc      480
Gly Glu Glu Met Arg Asp Arg Ala Arg Ala His Val Asp Ala Leu Arg         
145                 150                 155                 160         

acg cat ctg gcc ccc tac agc gac gag ctg cgc cag cgc ttg gcc gcg      528
Thr His Leu Ala Pro Tyr Ser Asp Glu Leu Arg Gln Arg Leu Ala Ala         
                165                 170                 175             

cgc ctt gag gct ctc aag gag aac ggc ggc gcc aga ctg gcc gag tac      576
Arg Leu Glu Ala Leu Lys Glu Asn Gly Gly Ala Arg Leu Ala Glu Tyr         
            180                 185                 190                 

cac gcc aag gcc acc gag cat ctg agc acg ctc agc gag aag gcc aag      624
His Ala Lys Ala Thr Glu His Leu Ser Thr Leu Ser Glu Lys Ala Lys         
        195                 200                 205                     

ccc gcg ctc gag gac ctc tgc caa ggc ctg ctg ccc gtg ctg gag agc      672
Pro Ala Leu Glu Asp Leu Cys Gln Gly Leu Leu Pro Val Leu Glu Ser         
    210                 215                 220                         

ttc aag gtc agc ttc ctg agc gct ctc gag gag tac act aag aag ctc      720
Phe Lys Val Ser Phe Leu Ser Ala Leu Glu Glu Tyr Thr Lys Lys Leu         
225                 230                 235                 240         

aac acc cag tga                                                      732
Asn Thr Gln                                                             
                                                                        


<210>  6
<211>  243
<212>  PRT
<213>  Homo sapiens

<400>  6

Asp Glu Pro Pro Gln Ser Pro Trp Asp Arg Val Lys Asp Leu Ala Thr 
1               5                   10                  15      


Val Tyr Val Asp Val Leu Lys Asp Ser Gly Arg Asp Tyr Val Ser Gln 
            20                  25                  30          


Phe Glu Gly Ser Ala Leu Gly Lys Gln Leu Asn Leu Lys Leu Leu Asp 
        35                  40                  45              


Asn Trp Asp Ser Val Thr Ser Thr Phe Ser Lys Leu Arg Glu Gln Leu 
    50                  55                  60                  


Gly Pro Val Thr Gln Glu Phe Trp Asp Asn Leu Glu Lys Glu Thr Glu 
65                  70                  75                  80  


Gly Leu Arg Gln Glu Met Ser Lys Asp Leu Glu Glu Val Lys Ala Lys 
                85                  90                  95      


Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu Met 
            100                 105                 110         


Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu Arg Ala Glu Leu Gln Glu 
        115                 120                 125             


Gly Ala Arg Gln Lys Leu His Glu Leu Gln Glu Lys Leu Ser Pro Leu 
    130                 135                 140                 


Gly Glu Glu Met Arg Asp Arg Ala Arg Ala His Val Asp Ala Leu Arg 
145                 150                 155                 160 


Thr His Leu Ala Pro Tyr Ser Asp Glu Leu Arg Gln Arg Leu Ala Ala 
                165                 170                 175     


Arg Leu Glu Ala Leu Lys Glu Asn Gly Gly Ala Arg Leu Ala Glu Tyr 
            180                 185                 190         


His Ala Lys Ala Thr Glu His Leu Ser Thr Leu Ser Glu Lys Ala Lys 
        195                 200                 205             


Pro Ala Leu Glu Asp Leu Cys Gln Gly Leu Leu Pro Val Leu Glu Ser 
    210                 215                 220                 


Phe Lys Val Ser Phe Leu Ser Ala Leu Glu Glu Tyr Thr Lys Lys Leu 
225                 230                 235                 240 


Asn Thr Gln 
            


<210>  7
<211>  732
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(732)
<223>  Mutein of human Apo A-1 

R173C, R215C

<400>  7
gat gaa ccc ccc cag agc ccc tgg gat cga gtg aag gac ctg gcc act       48
Asp Glu Pro Pro Gln Ser Pro Trp Asp Arg Val Lys Asp Leu Ala Thr         
1               5                   10                  15              

gtg tac gtg gat gtg ctc aaa gac agc ggc aga gac tat gtg tcc cag       96
Val Tyr Val Asp Val Leu Lys Asp Ser Gly Arg Asp Tyr Val Ser Gln         
            20                  25                  30                  

ttt gaa ggc tcc gcc ttg gga aaa cag cta aac cta aag ctc ctt gac      144
Phe Glu Gly Ser Ala Leu Gly Lys Gln Leu Asn Leu Lys Leu Leu Asp         
        35                  40                  45                      

aac tgg gac agc gtg acc tcc acc ttc agc aag ctg cgc gaa cag ctc      192
Asn Trp Asp Ser Val Thr Ser Thr Phe Ser Lys Leu Arg Glu Gln Leu         
    50                  55                  60                          

ggc cct gtg acc cag gag ttc tgg gat aac ctg gaa aag gag aca gag      240
Gly Pro Val Thr Gln Glu Phe Trp Asp Asn Leu Glu Lys Glu Thr Glu         
65                  70                  75                  80          

ggc ctg agg caa gag atg agc aag gat ctg gag gag gtg aag gcc aag      288
Gly Leu Arg Gln Glu Met Ser Lys Asp Leu Glu Glu Val Lys Ala Lys         
                85                  90                  95              

gtg cag ccc tac ctg gac gac ttc cag aag aag tgg cag gag gag atg      336
Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu Met         
            100                 105                 110                 

gag ctc tac cgc cag aag gtg gag ccg ctg cgc gca gag ctc caa gag      384
Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu Arg Ala Glu Leu Gln Glu         
        115                 120                 125                     

ggc gcg cgc cag aag ctg cac gag ctg caa gag aag ctg agc cca ctg      432
Gly Ala Arg Gln Lys Leu His Glu Leu Gln Glu Lys Leu Ser Pro Leu         
    130                 135                 140                         

ggc gag gag atg cgc gac cgc gcg cgc gcc cat gtg gac gcg ctg cgc      480
Gly Glu Glu Met Arg Asp Arg Ala Arg Ala His Val Asp Ala Leu Arg         
145                 150                 155                 160         

acg cat ctg gcc ccc tac agc gac gag ctg cgc cag tgc ttg gcc gcg      528
Thr His Leu Ala Pro Tyr Ser Asp Glu Leu Arg Gln Cys Leu Ala Ala         
                165                 170                 175             

cgc ctt gag gct ctc aag gag aac ggc ggc gcc aga ctg gcc gag tac      576
Arg Leu Glu Ala Leu Lys Glu Asn Gly Gly Ala Arg Leu Ala Glu Tyr         
            180                 185                 190                 

cac gcc aag gcc acc gag cat ctg agc acg ctc agc gag aag gcc aag      624
His Ala Lys Ala Thr Glu His Leu Ser Thr Leu Ser Glu Lys Ala Lys         
        195                 200                 205                     

ccc gcg ctc gag gac ctc tgc caa ggc ctg ctg ccc gtg ctg gag agc      672
Pro Ala Leu Glu Asp Leu Cys Gln Gly Leu Leu Pro Val Leu Glu Ser         
    210                 215                 220                         

ttc aag gtc agc ttc ctg agc gct ctc gag gag tac act aag aag ctc      720
Phe Lys Val Ser Phe Leu Ser Ala Leu Glu Glu Tyr Thr Lys Lys Leu         
225                 230                 235                 240         

aac acc cag tga                                                      732
Asn Thr Gln                                                             
                                                                        


<210>  8
<211>  243
<212>  PRT
<213>  Homo sapiens

<400>  8

Asp Glu Pro Pro Gln Ser Pro Trp Asp Arg Val Lys Asp Leu Ala Thr 
1               5                   10                  15      


Val Tyr Val Asp Val Leu Lys Asp Ser Gly Arg Asp Tyr Val Ser Gln 
            20                  25                  30          


Phe Glu Gly Ser Ala Leu Gly Lys Gln Leu Asn Leu Lys Leu Leu Asp 
        35                  40                  45              


Asn Trp Asp Ser Val Thr Ser Thr Phe Ser Lys Leu Arg Glu Gln Leu 
    50                  55                  60                  


Gly Pro Val Thr Gln Glu Phe Trp Asp Asn Leu Glu Lys Glu Thr Glu 
65                  70                  75                  80  


Gly Leu Arg Gln Glu Met Ser Lys Asp Leu Glu Glu Val Lys Ala Lys 
                85                  90                  95      


Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu Met 
            100                 105                 110         


Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu Arg Ala Glu Leu Gln Glu 
        115                 120                 125             


Gly Ala Arg Gln Lys Leu His Glu Leu Gln Glu Lys Leu Ser Pro Leu 
    130                 135                 140                 


Gly Glu Glu Met Arg Asp Arg Ala Arg Ala His Val Asp Ala Leu Arg 
145                 150                 155                 160 


Thr His Leu Ala Pro Tyr Ser Asp Glu Leu Arg Gln Cys Leu Ala Ala 
                165                 170                 175     


Arg Leu Glu Ala Leu Lys Glu Asn Gly Gly Ala Arg Leu Ala Glu Tyr 
            180                 185                 190         


His Ala Lys Ala Thr Glu His Leu Ser Thr Leu Ser Glu Lys Ala Lys 
        195                 200                 205             


Pro Ala Leu Glu Asp Leu Cys Gln Gly Leu Leu Pro Val Leu Glu Ser 
    210                 215                 220                 


Phe Lys Val Ser Phe Leu Ser Ala Leu Glu Glu Tyr Thr Lys Lys Leu 
225                 230                 235                 240 


Asn Thr Gln 
            


<210>  9
<211>  732
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(732)
<223>  Mutein of human Apo A-1 

R123C, R215C

<400>  9
gat gaa ccc ccc cag agc ccc tgg gat cga gtg aag gac ctg gcc act       48
Asp Glu Pro Pro Gln Ser Pro Trp Asp Arg Val Lys Asp Leu Ala Thr         
1               5                   10                  15              

gtg tac gtg gat gtg ctc aaa gac agc ggc aga gac tat gtg tcc cag       96
Val Tyr Val Asp Val Leu Lys Asp Ser Gly Arg Asp Tyr Val Ser Gln         
            20                  25                  30                  

ttt gaa ggc tcc gcc ttg gga aaa cag cta aac cta aag ctc ctt gac      144
Phe Glu Gly Ser Ala Leu Gly Lys Gln Leu Asn Leu Lys Leu Leu Asp         
        35                  40                  45                      

aac tgg gac agc gtg acc tcc acc ttc agc aag ctg cgc gaa cag ctc      192
Asn Trp Asp Ser Val Thr Ser Thr Phe Ser Lys Leu Arg Glu Gln Leu         
    50                  55                  60                          

ggc cct gtg acc cag gag ttc tgg gat aac ctg gaa aag gag aca gag      240
Gly Pro Val Thr Gln Glu Phe Trp Asp Asn Leu Glu Lys Glu Thr Glu         
65                  70                  75                  80          

ggc ctg agg caa gag atg agc aag gat ctg gag gag gtg aag gcc aag      288
Gly Leu Arg Gln Glu Met Ser Lys Asp Leu Glu Glu Val Lys Ala Lys         
                85                  90                  95              

gtg cag ccc tac ctg gac gac ttc cag aag aag tgg cag gag gag atg      336
Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu Met         
            100                 105                 110                 

gag ctc tac cgc cag aag gtg gag ccg ctg tgc gca gag ctc caa gag      384
Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu Cys Ala Glu Leu Gln Glu         
        115                 120                 125                     

ggc gcg cgc cag aag ctg cac gag ctg caa gag aag ctg agc cca ctg      432
Gly Ala Arg Gln Lys Leu His Glu Leu Gln Glu Lys Leu Ser Pro Leu         
    130                 135                 140                         

ggc gag gag atg cgc gac cgc gcg cgc gcc cat gtg gac gcg ctg cgc      480
Gly Glu Glu Met Arg Asp Arg Ala Arg Ala His Val Asp Ala Leu Arg         
145                 150                 155                 160         

acg cat ctg gcc ccc tac agc gac gag ctg cgc cag cgc ttg gcc gcg      528
Thr His Leu Ala Pro Tyr Ser Asp Glu Leu Arg Gln Arg Leu Ala Ala         
                165                 170                 175             

cgc ctt gag gct ctc aag gag aac ggc ggc gcc aga ctg gcc gag tac      576
Arg Leu Glu Ala Leu Lys Glu Asn Gly Gly Ala Arg Leu Ala Glu Tyr         
            180                 185                 190                 

cac gcc aag gcc acc gag cat ctg agc acg ctc agc gag aag gcc aag      624
His Ala Lys Ala Thr Glu His Leu Ser Thr Leu Ser Glu Lys Ala Lys         
        195                 200                 205                     

ccc gcg ctc gag gac ctc tgc caa ggc ctg ctg ccc gtg ctg gag agc      672
Pro Ala Leu Glu Asp Leu Cys Gln Gly Leu Leu Pro Val Leu Glu Ser         
    210                 215                 220                         

ttc aag gtc agc ttc ctg agc gct ctc gag gag tac act aag aag ctc      720
Phe Lys Val Ser Phe Leu Ser Ala Leu Glu Glu Tyr Thr Lys Lys Leu         
225                 230                 235                 240         

aac acc cag tga                                                      732
Asn Thr Gln                                                             
                                                                        


<210>  10
<211>  243
<212>  PRT
<213>  Homo sapiens

<400>  10

Asp Glu Pro Pro Gln Ser Pro Trp Asp Arg Val Lys Asp Leu Ala Thr 
1               5                   10                  15      


Val Tyr Val Asp Val Leu Lys Asp Ser Gly Arg Asp Tyr Val Ser Gln 
            20                  25                  30          


Phe Glu Gly Ser Ala Leu Gly Lys Gln Leu Asn Leu Lys Leu Leu Asp 
        35                  40                  45              


Asn Trp Asp Ser Val Thr Ser Thr Phe Ser Lys Leu Arg Glu Gln Leu 
    50                  55                  60                  


Gly Pro Val Thr Gln Glu Phe Trp Asp Asn Leu Glu Lys Glu Thr Glu 
65                  70                  75                  80  


Gly Leu Arg Gln Glu Met Ser Lys Asp Leu Glu Glu Val Lys Ala Lys 
                85                  90                  95      


Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu Met 
            100                 105                 110         


Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu Cys Ala Glu Leu Gln Glu 
        115                 120                 125             


Gly Ala Arg Gln Lys Leu His Glu Leu Gln Glu Lys Leu Ser Pro Leu 
    130                 135                 140                 


Gly Glu Glu Met Arg Asp Arg Ala Arg Ala His Val Asp Ala Leu Arg 
145                 150                 155                 160 


Thr His Leu Ala Pro Tyr Ser Asp Glu Leu Arg Gln Arg Leu Ala Ala 
                165                 170                 175     


Arg Leu Glu Ala Leu Lys Glu Asn Gly Gly Ala Arg Leu Ala Glu Tyr 
            180                 185                 190         


His Ala Lys Ala Thr Glu His Leu Ser Thr Leu Ser Glu Lys Ala Lys 
        195                 200                 205             


Pro Ala Leu Glu Asp Leu Cys Gln Gly Leu Leu Pro Val Leu Glu Ser 
    210                 215                 220                 


Phe Lys Val Ser Phe Leu Ser Ala Leu Glu Glu Tyr Thr Lys Lys Leu 
225                 230                 235                 240 


Asn Thr Gln 
            


<210>  11
<211>  732
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(732)
<223>  Mutein of human Apo A-1 

R10C

<400>  11
gat gaa ccc ccc cag agc ccc tgg gat tgt gtg aag gac ctg gcc act       48
Asp Glu Pro Pro Gln Ser Pro Trp Asp Cys Val Lys Asp Leu Ala Thr         
1               5                   10                  15              

gtg tac gtg gat gtg ctc aaa gac agc ggc aga gac tat gtg tcc cag       96
Val Tyr Val Asp Val Leu Lys Asp Ser Gly Arg Asp Tyr Val Ser Gln         
            20                  25                  30                  

ttt gaa ggc tcc gcc ttg gga aaa cag cta aac cta aag ctc ctt gac      144
Phe Glu Gly Ser Ala Leu Gly Lys Gln Leu Asn Leu Lys Leu Leu Asp         
        35                  40                  45                      

aac tgg gac agc gtg acc tcc acc ttc agc aag ctg cgc gaa cag ctc      192
Asn Trp Asp Ser Val Thr Ser Thr Phe Ser Lys Leu Arg Glu Gln Leu         
    50                  55                  60                          

ggc cct gtg acc cag gag ttc tgg gat aac ctg gaa aag gag aca gag      240
Gly Pro Val Thr Gln Glu Phe Trp Asp Asn Leu Glu Lys Glu Thr Glu         
65                  70                  75                  80          

ggc ctg agg caa gag atg agc aag gat ctg gag gag gtg aag gcc aag      288
Gly Leu Arg Gln Glu Met Ser Lys Asp Leu Glu Glu Val Lys Ala Lys         
                85                  90                  95              

gtg cag ccc tac ctg gac gac ttc cag aag aag tgg cag gag gag atg      336
Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu Met         
            100                 105                 110                 

gag ctc tac cgc cag aag gtg gag ccg ctg cgc gca gag ctc caa gag      384
Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu Arg Ala Glu Leu Gln Glu         
        115                 120                 125                     

ggc gcg cgc cag aag ctg cac gag ctg caa gag aag ctg agc cca ctg      432
Gly Ala Arg Gln Lys Leu His Glu Leu Gln Glu Lys Leu Ser Pro Leu         
    130                 135                 140                         

ggc gag gag atg cgc gac cgc gcg cgc gcc cat gtg gac gcg ctg cgc      480
Gly Glu Glu Met Arg Asp Arg Ala Arg Ala His Val Asp Ala Leu Arg         
145                 150                 155                 160         

acg cat ctg gcc ccc tac agc gac gag ctg cgc cag cgc ttg gcc gcg      528
Thr His Leu Ala Pro Tyr Ser Asp Glu Leu Arg Gln Arg Leu Ala Ala         
                165                 170                 175             

cgc ctt gag gct ctc aag gag aac ggc ggc gcc aga ctg gcc gag tac      576
Arg Leu Glu Ala Leu Lys Glu Asn Gly Gly Ala Arg Leu Ala Glu Tyr         
            180                 185                 190                 

cac gcc aag gcc acc gag cat ctg agc acg ctc agc gag aag gcc aag      624
His Ala Lys Ala Thr Glu His Leu Ser Thr Leu Ser Glu Lys Ala Lys         
        195                 200                 205                     

ccc gcg ctc gag gac ctc cgc caa ggc ctg ctg ccc gtg ctg gag agc      672
Pro Ala Leu Glu Asp Leu Arg Gln Gly Leu Leu Pro Val Leu Glu Ser         
    210                 215                 220                         

ttc aag gtc agc ttc ctg agc gct ctc gag gag tac act aag aag ctc      720
Phe Lys Val Ser Phe Leu Ser Ala Leu Glu Glu Tyr Thr Lys Lys Leu         
225                 230                 235                 240         

aac acc cag tga                                                      732
Asn Thr Gln                                                             
                                                                        


<210>  12
<211>  243
<212>  PRT
<213>  Homo sapiens

<400>  12

Asp Glu Pro Pro Gln Ser Pro Trp Asp Cys Val Lys Asp Leu Ala Thr 
1               5                   10                  15      


Val Tyr Val Asp Val Leu Lys Asp Ser Gly Arg Asp Tyr Val Ser Gln 
            20                  25                  30          


Phe Glu Gly Ser Ala Leu Gly Lys Gln Leu Asn Leu Lys Leu Leu Asp 
        35                  40                  45              


Asn Trp Asp Ser Val Thr Ser Thr Phe Ser Lys Leu Arg Glu Gln Leu 
    50                  55                  60                  


Gly Pro Val Thr Gln Glu Phe Trp Asp Asn Leu Glu Lys Glu Thr Glu 
65                  70                  75                  80  


Gly Leu Arg Gln Glu Met Ser Lys Asp Leu Glu Glu Val Lys Ala Lys 
                85                  90                  95      


Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu Met 
            100                 105                 110         


Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu Arg Ala Glu Leu Gln Glu 
        115                 120                 125             


Gly Ala Arg Gln Lys Leu His Glu Leu Gln Glu Lys Leu Ser Pro Leu 
    130                 135                 140                 


Gly Glu Glu Met Arg Asp Arg Ala Arg Ala His Val Asp Ala Leu Arg 
145                 150                 155                 160 


Thr His Leu Ala Pro Tyr Ser Asp Glu Leu Arg Gln Arg Leu Ala Ala 
                165                 170                 175     


Arg Leu Glu Ala Leu Lys Glu Asn Gly Gly Ala Arg Leu Ala Glu Tyr 
            180                 185                 190         


His Ala Lys Ala Thr Glu His Leu Ser Thr Leu Ser Glu Lys Ala Lys 
        195                 200                 205             


Pro Ala Leu Glu Asp Leu Arg Gln Gly Leu Leu Pro Val Leu Glu Ser 
    210                 215                 220                 


Phe Lys Val Ser Phe Leu Ser Ala Leu Glu Glu Tyr Thr Lys Lys Leu 
225                 230                 235                 240 


Asn Thr Gln 
            


<210>  13
<211>  732
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(732)
<223>  Mutein of human Apo A-1 

R61C

<400>  13
gat gaa ccc ccc cag agc ccc tgg gat cga gtg aag gac ctg gcc act       48
Asp Glu Pro Pro Gln Ser Pro Trp Asp Arg Val Lys Asp Leu Ala Thr         
1               5                   10                  15              

gtg tac gtg gat gtg ctc aaa gac agc ggc aga gac tat gtg tcc cag       96
Val Tyr Val Asp Val Leu Lys Asp Ser Gly Arg Asp Tyr Val Ser Gln         
            20                  25                  30                  

ttt gaa ggc tcc gcc ttg gga aaa cag cta aac cta aag ctc ctt gac      144
Phe Glu Gly Ser Ala Leu Gly Lys Gln Leu Asn Leu Lys Leu Leu Asp         
        35                  40                  45                      

aac tgg gac agc gtg acc tcc acc ttc agc aag ctg tgc gaa cag ctc      192
Asn Trp Asp Ser Val Thr Ser Thr Phe Ser Lys Leu Cys Glu Gln Leu         
    50                  55                  60                          

ggc cct gtg acc cag gag ttc tgg gat aac ctg gaa aag gag aca gag      240
Gly Pro Val Thr Gln Glu Phe Trp Asp Asn Leu Glu Lys Glu Thr Glu         
65                  70                  75                  80          

ggc ctg agg caa gag atg agc aag gat ctg gag gag gtg aag gcc aag      288
Gly Leu Arg Gln Glu Met Ser Lys Asp Leu Glu Glu Val Lys Ala Lys         
                85                  90                  95              

gtg cag ccc tac ctg gac gac ttc cag aag aag tgg cag gag gag atg      336
Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu Met         
            100                 105                 110                 

gag ctc tac cgc cag aag gtg gag ccg ctg cgc gca gag ctc caa gag      384
Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu Arg Ala Glu Leu Gln Glu         
        115                 120                 125                     

ggc gcg cgc cag aag ctg cac gag ctg caa gag aag ctg agc cca ctg      432
Gly Ala Arg Gln Lys Leu His Glu Leu Gln Glu Lys Leu Ser Pro Leu         
    130                 135                 140                         

ggc gag gag atg cgc gac cgc gcg cgc gcc cat gtg gac gcg ctg cgc      480
Gly Glu Glu Met Arg Asp Arg Ala Arg Ala His Val Asp Ala Leu Arg         
145                 150                 155                 160         

acg cat ctg gcc ccc tac agc gac gag ctg cgc cag cgc ttg gcc gcg      528
Thr His Leu Ala Pro Tyr Ser Asp Glu Leu Arg Gln Arg Leu Ala Ala         
                165                 170                 175             

cgc ctt gag gct ctc aag gag aac ggc ggc gcc aga ctg gcc gag tac      576
Arg Leu Glu Ala Leu Lys Glu Asn Gly Gly Ala Arg Leu Ala Glu Tyr         
            180                 185                 190                 

cac gcc aag gcc acc gag cat ctg agc acg ctc agc gag aag gcc aag      624
His Ala Lys Ala Thr Glu His Leu Ser Thr Leu Ser Glu Lys Ala Lys         
        195                 200                 205                     

ccc gcg ctc gag gac ctc cgc caa ggc ctg ctg ccc gtg ctg gag agc      672
Pro Ala Leu Glu Asp Leu Arg Gln Gly Leu Leu Pro Val Leu Glu Ser         
    210                 215                 220                         

ttc aag gtc agc ttc ctg agc gct ctc gag gag tac act aag aag ctc      720
Phe Lys Val Ser Phe Leu Ser Ala Leu Glu Glu Tyr Thr Lys Lys Leu         
225                 230                 235                 240         

aac acc cag tga                                                      732
Asn Thr Gln                                                             
                                                                        


<210>  14
<211>  243
<212>  PRT
<213>  Homo sapiens

<400>  14

Asp Glu Pro Pro Gln Ser Pro Trp Asp Arg Val Lys Asp Leu Ala Thr 
1               5                   10                  15      


Val Tyr Val Asp Val Leu Lys Asp Ser Gly Arg Asp Tyr Val Ser Gln 
            20                  25                  30          


Phe Glu Gly Ser Ala Leu Gly Lys Gln Leu Asn Leu Lys Leu Leu Asp 
        35                  40                  45              


Asn Trp Asp Ser Val Thr Ser Thr Phe Ser Lys Leu Cys Glu Gln Leu 
    50                  55                  60                  


Gly Pro Val Thr Gln Glu Phe Trp Asp Asn Leu Glu Lys Glu Thr Glu 
65                  70                  75                  80  


Gly Leu Arg Gln Glu Met Ser Lys Asp Leu Glu Glu Val Lys Ala Lys 
                85                  90                  95      


Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu Met 
            100                 105                 110         


Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu Arg Ala Glu Leu Gln Glu 
        115                 120                 125             


Gly Ala Arg Gln Lys Leu His Glu Leu Gln Glu Lys Leu Ser Pro Leu 
    130                 135                 140                 


Gly Glu Glu Met Arg Asp Arg Ala Arg Ala His Val Asp Ala Leu Arg 
145                 150                 155                 160 


Thr His Leu Ala Pro Tyr Ser Asp Glu Leu Arg Gln Arg Leu Ala Ala 
                165                 170                 175     


Arg Leu Glu Ala Leu Lys Glu Asn Gly Gly Ala Arg Leu Ala Glu Tyr 
            180                 185                 190         


His Ala Lys Ala Thr Glu His Leu Ser Thr Leu Ser Glu Lys Ala Lys 
        195                 200                 205             


Pro Ala Leu Glu Asp Leu Arg Gln Gly Leu Leu Pro Val Leu Glu Ser 
    210                 215                 220                 


Phe Lys Val Ser Phe Leu Ser Ala Leu Glu Glu Tyr Thr Lys Lys Leu 
225                 230                 235                 240 


Asn Thr Gln 
            


<210>  15
<211>  732
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(732)
<223>  Mutein of human Apo A-1 

R83C

<400>  15
gat gaa ccc ccc cag agc ccc tgg gat cga gtg aag gac ctg gcc act       48
Asp Glu Pro Pro Gln Ser Pro Trp Asp Arg Val Lys Asp Leu Ala Thr         
1               5                   10                  15              

gtg tac gtg gat gtg ctc aaa gac agc ggc aga gac tat gtg tcc cag       96
Val Tyr Val Asp Val Leu Lys Asp Ser Gly Arg Asp Tyr Val Ser Gln         
            20                  25                  30                  

ttt gaa ggc tcc gcc ttg gga aaa cag cta aac cta aag ctc ctt gac      144
Phe Glu Gly Ser Ala Leu Gly Lys Gln Leu Asn Leu Lys Leu Leu Asp         
        35                  40                  45                      

aac tgg gac agc gtg acc tcc acc ttc agc aag ctg cgc gaa cag ctc      192
Asn Trp Asp Ser Val Thr Ser Thr Phe Ser Lys Leu Arg Glu Gln Leu         
    50                  55                  60                          

ggc cct gtg acc cag gag ttc tgg gat aac ctg gaa aag gag aca gag      240
Gly Pro Val Thr Gln Glu Phe Trp Asp Asn Leu Glu Lys Glu Thr Glu         
65                  70                  75                  80          

ggc ctg tgc caa gag atg agc aag gat ctg gag gag gtg aag gcc aag      288
Gly Leu Cys Gln Glu Met Ser Lys Asp Leu Glu Glu Val Lys Ala Lys         
                85                  90                  95              

gtg cag ccc tac ctg gac gac ttc cag aag aag tgg cag gag gag atg      336
Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu Met         
            100                 105                 110                 

gag ctc tac cgc cag aag gtg gag ccg ctg cgc gca gag ctc caa gag      384
Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu Arg Ala Glu Leu Gln Glu         
        115                 120                 125                     

ggc gcg cgc cag aag ctg cac gag ctg caa gag aag ctg agc cca ctg      432
Gly Ala Arg Gln Lys Leu His Glu Leu Gln Glu Lys Leu Ser Pro Leu         
    130                 135                 140                         

ggc gag gag atg cgc gac cgc gcg cgc gcc cat gtg gac gcg ctg cgc      480
Gly Glu Glu Met Arg Asp Arg Ala Arg Ala His Val Asp Ala Leu Arg         
145                 150                 155                 160         

acg cat ctg gcc ccc tac agc gac gag ctg cgc cag cgc ttg gcc gcg      528
Thr His Leu Ala Pro Tyr Ser Asp Glu Leu Arg Gln Arg Leu Ala Ala         
                165                 170                 175             

cgc ctt gag gct ctc aag gag aac ggc ggc gcc aga ctg gcc gag tac      576
Arg Leu Glu Ala Leu Lys Glu Asn Gly Gly Ala Arg Leu Ala Glu Tyr         
            180                 185                 190                 

cac gcc aag gcc acc gag cat ctg agc acg ctc agc gag aag gcc aag      624
His Ala Lys Ala Thr Glu His Leu Ser Thr Leu Ser Glu Lys Ala Lys         
        195                 200                 205                     

ccc gcg ctc gag gac ctc cgc caa ggc ctg ctg ccc gtg ctg gag agc      672
Pro Ala Leu Glu Asp Leu Arg Gln Gly Leu Leu Pro Val Leu Glu Ser         
    210                 215                 220                         

ttc aag gtc agc ttc ctg agc gct ctc gag gag tac act aag aag ctc      720
Phe Lys Val Ser Phe Leu Ser Ala Leu Glu Glu Tyr Thr Lys Lys Leu         
225                 230                 235                 240         

aac acc cag tga                                                      732
Asn Thr Gln                                                             
                                                                        


<210>  16
<211>  243
<212>  PRT
<213>  Homo sapiens

<400>  16

Asp Glu Pro Pro Gln Ser Pro Trp Asp Arg Val Lys Asp Leu Ala Thr 
1               5                   10                  15      


Val Tyr Val Asp Val Leu Lys Asp Ser Gly Arg Asp Tyr Val Ser Gln 
            20                  25                  30          


Phe Glu Gly Ser Ala Leu Gly Lys Gln Leu Asn Leu Lys Leu Leu Asp 
        35                  40                  45              


Asn Trp Asp Ser Val Thr Ser Thr Phe Ser Lys Leu Arg Glu Gln Leu 
    50                  55                  60                  


Gly Pro Val Thr Gln Glu Phe Trp Asp Asn Leu Glu Lys Glu Thr Glu 
65                  70                  75                  80  


Gly Leu Cys Gln Glu Met Ser Lys Asp Leu Glu Glu Val Lys Ala Lys 
                85                  90                  95      


Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu Met 
            100                 105                 110         


Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu Arg Ala Glu Leu Gln Glu 
        115                 120                 125             


Gly Ala Arg Gln Lys Leu His Glu Leu Gln Glu Lys Leu Ser Pro Leu 
    130                 135                 140                 


Gly Glu Glu Met Arg Asp Arg Ala Arg Ala His Val Asp Ala Leu Arg 
145                 150                 155                 160 


Thr His Leu Ala Pro Tyr Ser Asp Glu Leu Arg Gln Arg Leu Ala Ala 
                165                 170                 175     


Arg Leu Glu Ala Leu Lys Glu Asn Gly Gly Ala Arg Leu Ala Glu Tyr 
            180                 185                 190         


His Ala Lys Ala Thr Glu His Leu Ser Thr Leu Ser Glu Lys Ala Lys 
        195                 200                 205             


Pro Ala Leu Glu Asp Leu Arg Gln Gly Leu Leu Pro Val Leu Glu Ser 
    210                 215                 220                 


Phe Lys Val Ser Phe Leu Ser Ala Leu Glu Glu Tyr Thr Lys Lys Leu 
225                 230                 235                 240 


Asn Thr Gln 
            


<210>  17
<211>  732
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(723)
<223>  Mutein of human Apo A-1 

R151C

<400>  17
gat gaa ccc ccc cag agc ccc tgg gat cga gtg aag gac ctg gcc act       48
Asp Glu Pro Pro Gln Ser Pro Trp Asp Arg Val Lys Asp Leu Ala Thr         
1               5                   10                  15              

gtg tac gtg gat gtg ctc aaa gac agc ggc aga gac tat gtg tcc cag       96
Val Tyr Val Asp Val Leu Lys Asp Ser Gly Arg Asp Tyr Val Ser Gln         
            20                  25                  30                  

ttt gaa ggc tcc gcc ttg gga aaa cag cta aac cta aag ctc ctt gac      144
Phe Glu Gly Ser Ala Leu Gly Lys Gln Leu Asn Leu Lys Leu Leu Asp         
        35                  40                  45                      

aac tgg gac agc gtg acc tcc acc ttc agc aag ctg cgc gaa cag ctc      192
Asn Trp Asp Ser Val Thr Ser Thr Phe Ser Lys Leu Arg Glu Gln Leu         
    50                  55                  60                          

ggc cct gtg acc cag gag ttc tgg gat aac ctg gaa aag gag aca gag      240
Gly Pro Val Thr Gln Glu Phe Trp Asp Asn Leu Glu Lys Glu Thr Glu         
65                  70                  75                  80          

ggc ctg agg caa gag atg agc aag gat ctg gag gag gtg aag gcc aag      288
Gly Leu Arg Gln Glu Met Ser Lys Asp Leu Glu Glu Val Lys Ala Lys         
                85                  90                  95              

gtg cag ccc tac ctg gac gac ttc cag aag aag tgg cag gag gag atg      336
Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu Met         
            100                 105                 110                 

gag ctc tac cgc cag aag gtg gag ccg ctg cgc gca gag ctc caa gag      384
Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu Arg Ala Glu Leu Gln Glu         
        115                 120                 125                     

ggc gcg cgc cag aag ctg cac gag ctg caa gag aag ctg agc cca ctg      432
Gly Ala Arg Gln Lys Leu His Glu Leu Gln Glu Lys Leu Ser Pro Leu         
    130                 135                 140                         

ggc gag gag atg cgc gac tgc gcg cgc gcc cat gtg gac gcg ctg cgc      480
Gly Glu Glu Met Arg Asp Cys Ala Arg Ala His Val Asp Ala Leu Arg         
145                 150                 155                 160         

acg cat ctg gcc ccc tac agc gac gag ctg cgc cag cgc ttg gcc gcg      528
Thr His Leu Ala Pro Tyr Ser Asp Glu Leu Arg Gln Arg Leu Ala Ala         
                165                 170                 175             

cgc ctt gag gct ctc aag gag aac ggc ggc gcc aga ctg gcc gag tac      576
Arg Leu Glu Ala Leu Lys Glu Asn Gly Gly Ala Arg Leu Ala Glu Tyr         
            180                 185                 190                 

cac gcc aag gcc acc gag cat ctg agc acg ctc agc gag aag gcc aag      624
His Ala Lys Ala Thr Glu His Leu Ser Thr Leu Ser Glu Lys Ala Lys         
        195                 200                 205                     

ccc gcg ctc gag gac ctc cgc caa ggc ctg ctg ccc gtg ctg gag agc      672
Pro Ala Leu Glu Asp Leu Arg Gln Gly Leu Leu Pro Val Leu Glu Ser         
    210                 215                 220                         

ttc aag gtc agc ttc ctg agc gct ctc gag gag tac act aag aag ctc      720
Phe Lys Val Ser Phe Leu Ser Ala Leu Glu Glu Tyr Thr Lys Lys Leu         
225                 230                 235                 240         

aac acccagtga                                                        732
Asn                                                                     
                                                                        


<210>  18
<211>  241
<212>  PRT
<213>  Homo sapiens

<400>  18

Asp Glu Pro Pro Gln Ser Pro Trp Asp Arg Val Lys Asp Leu Ala Thr 
1               5                   10                  15      


Val Tyr Val Asp Val Leu Lys Asp Ser Gly Arg Asp Tyr Val Ser Gln 
            20                  25                  30          


Phe Glu Gly Ser Ala Leu Gly Lys Gln Leu Asn Leu Lys Leu Leu Asp 
        35                  40                  45              


Asn Trp Asp Ser Val Thr Ser Thr Phe Ser Lys Leu Arg Glu Gln Leu 
    50                  55                  60                  


Gly Pro Val Thr Gln Glu Phe Trp Asp Asn Leu Glu Lys Glu Thr Glu 
65                  70                  75                  80  


Gly Leu Arg Gln Glu Met Ser Lys Asp Leu Glu Glu Val Lys Ala Lys 
                85                  90                  95      


Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu Met 
            100                 105                 110         


Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu Arg Ala Glu Leu Gln Glu 
        115                 120                 125             


Gly Ala Arg Gln Lys Leu His Glu Leu Gln Glu Lys Leu Ser Pro Leu 
    130                 135                 140                 


Gly Glu Glu Met Arg Asp Cys Ala Arg Ala His Val Asp Ala Leu Arg 
145                 150                 155                 160 


Thr His Leu Ala Pro Tyr Ser Asp Glu Leu Arg Gln Arg Leu Ala Ala 
                165                 170                 175     


Arg Leu Glu Ala Leu Lys Glu Asn Gly Gly Ala Arg Leu Ala Glu Tyr 
            180                 185                 190         


His Ala Lys Ala Thr Glu His Leu Ser Thr Leu Ser Glu Lys Ala Lys 
        195                 200                 205             


Pro Ala Leu Glu Asp Leu Arg Gln Gly Leu Leu Pro Val Leu Glu Ser 
    210                 215                 220                 


Phe Lys Val Ser Phe Leu Ser Ala Leu Glu Glu Tyr Thr Lys Lys Leu 
225                 230                 235                 240 


Asn 
    


<210>  19
<211>  732
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(732)
<223>  Mutein of human Apo A-1 

R10C, R215C

<400>  19
gat gaa ccc ccc cag agc ccc tgg gat tgt gtg aag gac ctg gcc act       48
Asp Glu Pro Pro Gln Ser Pro Trp Asp Cys Val Lys Asp Leu Ala Thr         
1               5                   10                  15              

gtg tac gtg gat gtg ctc aaa gac agc ggc aga gac tat gtg tcc cag       96
Val Tyr Val Asp Val Leu Lys Asp Ser Gly Arg Asp Tyr Val Ser Gln         
            20                  25                  30                  

ttt gaa ggc tcc gcc ttg gga aaa cag cta aac cta aag ctc ctt gac      144
Phe Glu Gly Ser Ala Leu Gly Lys Gln Leu Asn Leu Lys Leu Leu Asp         
        35                  40                  45                      

aac tgg gac agc gtg acc tcc acc ttc agc aag ctg cgc gaa cag ctc      192
Asn Trp Asp Ser Val Thr Ser Thr Phe Ser Lys Leu Arg Glu Gln Leu         
    50                  55                  60                          

ggc cct gtg acc cag gag ttc tgg gat aac ctg gaa aag gag aca gag      240
Gly Pro Val Thr Gln Glu Phe Trp Asp Asn Leu Glu Lys Glu Thr Glu         
65                  70                  75                  80          

ggc ctg agg caa gag atg agc aag gat ctg gag gag gtg aag gcc aag      288
Gly Leu Arg Gln Glu Met Ser Lys Asp Leu Glu Glu Val Lys Ala Lys         
                85                  90                  95              

gtg cag ccc tac ctg gac gac ttc cag aag aag tgg cag gag gag atg      336
Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu Met         
            100                 105                 110                 

gag ctc tac cgc cag aag gtg gag ccg ctg cgc gca gag ctc caa gag      384
Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu Arg Ala Glu Leu Gln Glu         
        115                 120                 125                     

ggc gcg cgc cag aag ctg cac gag ctg caa gag aag ctg agc cca ctg      432
Gly Ala Arg Gln Lys Leu His Glu Leu Gln Glu Lys Leu Ser Pro Leu         
    130                 135                 140                         

ggc gag gag atg cgc gac cgc gcg cgc gcc cat gtg gac gcg ctg cgc      480
Gly Glu Glu Met Arg Asp Arg Ala Arg Ala His Val Asp Ala Leu Arg         
145                 150                 155                 160         

acg cat ctg gcc ccc tac agc gac gag ctg cgc cag cgc ttg gcc gcg      528
Thr His Leu Ala Pro Tyr Ser Asp Glu Leu Arg Gln Arg Leu Ala Ala         
                165                 170                 175             

cgc ctt gag gct ctc aag gag aac ggc ggc gcc aga ctg gcc gag tac      576
Arg Leu Glu Ala Leu Lys Glu Asn Gly Gly Ala Arg Leu Ala Glu Tyr         
            180                 185                 190                 

cac gcc aag gcc acc gag cat ctg agc acg ctc agc gag aag gcc aag      624
His Ala Lys Ala Thr Glu His Leu Ser Thr Leu Ser Glu Lys Ala Lys         
        195                 200                 205                     

ccc gcg ctc gag gac ctc tgc caa ggc ctg ctg ccc gtg ctg gag agc      672
Pro Ala Leu Glu Asp Leu Cys Gln Gly Leu Leu Pro Val Leu Glu Ser         
    210                 215                 220                         

ttc aag gtc agc ttc ctg agc gct ctc gag gag tac act aag aag ctc      720
Phe Lys Val Ser Phe Leu Ser Ala Leu Glu Glu Tyr Thr Lys Lys Leu         
225                 230                 235                 240         

aac acc cag tga                                                      732
Asn Thr Gln                                                             
                                                                        


<210>  20
<211>  243
<212>  PRT
<213>  Homo sapiens

<400>  20

Asp Glu Pro Pro Gln Ser Pro Trp Asp Cys Val Lys Asp Leu Ala Thr 
1               5                   10                  15      


Val Tyr Val Asp Val Leu Lys Asp Ser Gly Arg Asp Tyr Val Ser Gln 
            20                  25                  30          


Phe Glu Gly Ser Ala Leu Gly Lys Gln Leu Asn Leu Lys Leu Leu Asp 
        35                  40                  45              


Asn Trp Asp Ser Val Thr Ser Thr Phe Ser Lys Leu Arg Glu Gln Leu 
    50                  55                  60                  


Gly Pro Val Thr Gln Glu Phe Trp Asp Asn Leu Glu Lys Glu Thr Glu 
65                  70                  75                  80  


Gly Leu Arg Gln Glu Met Ser Lys Asp Leu Glu Glu Val Lys Ala Lys 
                85                  90                  95      


Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu Met 
            100                 105                 110         


Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu Arg Ala Glu Leu Gln Glu 
        115                 120                 125             


Gly Ala Arg Gln Lys Leu His Glu Leu Gln Glu Lys Leu Ser Pro Leu 
    130                 135                 140                 


Gly Glu Glu Met Arg Asp Arg Ala Arg Ala His Val Asp Ala Leu Arg 
145                 150                 155                 160 


Thr His Leu Ala Pro Tyr Ser Asp Glu Leu Arg Gln Arg Leu Ala Ala 
                165                 170                 175     


Arg Leu Glu Ala Leu Lys Glu Asn Gly Gly Ala Arg Leu Ala Glu Tyr 
            180                 185                 190         


His Ala Lys Ala Thr Glu His Leu Ser Thr Leu Ser Glu Lys Ala Lys 
        195                 200                 205             


Pro Ala Leu Glu Asp Leu Cys Gln Gly Leu Leu Pro Val Leu Glu Ser 
    210                 215                 220                 


Phe Lys Val Ser Phe Leu Ser Ala Leu Glu Glu Tyr Thr Lys Lys Leu 
225                 230                 235                 240 


Asn Thr Gln 
            


<210>  21
<211>  732
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(732)
<223>  Mutein of human Apo A-1 

R61C, R173C

<400>  21
gat gaa ccc ccc cag agc ccc tgg gat cga gtg aag gac ctg gcc act       48
Asp Glu Pro Pro Gln Ser Pro Trp Asp Arg Val Lys Asp Leu Ala Thr         
1               5                   10                  15              

gtg tac gtg gat gtg ctc aaa gac agc ggc aga gac tat gtg tcc cag       96
Val Tyr Val Asp Val Leu Lys Asp Ser Gly Arg Asp Tyr Val Ser Gln         
            20                  25                  30                  

ttt gaa ggc tcc gcc ttg gga aaa cag cta aac cta aag ctc ctt gac      144
Phe Glu Gly Ser Ala Leu Gly Lys Gln Leu Asn Leu Lys Leu Leu Asp         
        35                  40                  45                      

aac tgg gac agc gtg acc tcc acc ttc agc aag ctg tgc gaa cag ctc      192
Asn Trp Asp Ser Val Thr Ser Thr Phe Ser Lys Leu Cys Glu Gln Leu         
    50                  55                  60                          

ggc cct gtg acc cag gag ttc tgg gat aac ctg gaa aag gag aca gag      240
Gly Pro Val Thr Gln Glu Phe Trp Asp Asn Leu Glu Lys Glu Thr Glu         
65                  70                  75                  80          

ggc ctg agg caa gag atg agc aag gat ctg gag gag gtg aag gcc aag      288
Gly Leu Arg Gln Glu Met Ser Lys Asp Leu Glu Glu Val Lys Ala Lys         
                85                  90                  95              

gtg cag ccc tac ctg gac gac ttc cag aag aag tgg cag gag gag atg      336
Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu Met         
            100                 105                 110                 

gag ctc tac cgc cag aag gtg gag ccg ctg cgc gca gag ctc caa gag      384
Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu Arg Ala Glu Leu Gln Glu         
        115                 120                 125                     

ggc gcg cgc cag aag ctg cac gag ctg caa gag aag ctg agc cca ctg      432
Gly Ala Arg Gln Lys Leu His Glu Leu Gln Glu Lys Leu Ser Pro Leu         
    130                 135                 140                         

ggc gag gag atg cgc gac cgc gcg cgc gcc cat gtg gac gcg ctg cgc      480
Gly Glu Glu Met Arg Asp Arg Ala Arg Ala His Val Asp Ala Leu Arg         
145                 150                 155                 160         

acg cat ctg gcc ccc tac agc gac gag ctg cgc cag tgc ttg gcc gcg      528
Thr His Leu Ala Pro Tyr Ser Asp Glu Leu Arg Gln Cys Leu Ala Ala         
                165                 170                 175             

cgc ctt gag gct ctc aag gag aac ggc ggc gcc aga ctg gcc gag tac      576
Arg Leu Glu Ala Leu Lys Glu Asn Gly Gly Ala Arg Leu Ala Glu Tyr         
            180                 185                 190                 

cac gcc aag gcc acc gag cat ctg agc acg ctc agc gag aag gcc aag      624
His Ala Lys Ala Thr Glu His Leu Ser Thr Leu Ser Glu Lys Ala Lys         
        195                 200                 205                     

ccc gcg ctc gag gac ctc cgc caa ggc ctg ctg ccc gtg ctg gag agc      672
Pro Ala Leu Glu Asp Leu Arg Gln Gly Leu Leu Pro Val Leu Glu Ser         
    210                 215                 220                         

ttc aag gtc agc ttc ctg agc gct ctc gag gag tac act aag aag ctc      720
Phe Lys Val Ser Phe Leu Ser Ala Leu Glu Glu Tyr Thr Lys Lys Leu         
225                 230                 235                 240         

aac acc cag tga                                                      732
Asn Thr Gln                                                             
                                                                        


<210>  22
<211>  243
<212>  PRT
<213>  Homo sapiens

<400>  22

Asp Glu Pro Pro Gln Ser Pro Trp Asp Arg Val Lys Asp Leu Ala Thr 
1               5                   10                  15      


Val Tyr Val Asp Val Leu Lys Asp Ser Gly Arg Asp Tyr Val Ser Gln 
            20                  25                  30          


Phe Glu Gly Ser Ala Leu Gly Lys Gln Leu Asn Leu Lys Leu Leu Asp 
        35                  40                  45              


Asn Trp Asp Ser Val Thr Ser Thr Phe Ser Lys Leu Cys Glu Gln Leu 
    50                  55                  60                  


Gly Pro Val Thr Gln Glu Phe Trp Asp Asn Leu Glu Lys Glu Thr Glu 
65                  70                  75                  80  


Gly Leu Arg Gln Glu Met Ser Lys Asp Leu Glu Glu Val Lys Ala Lys 
                85                  90                  95      


Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu Met 
            100                 105                 110         


Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu Arg Ala Glu Leu Gln Glu 
        115                 120                 125             


Gly Ala Arg Gln Lys Leu His Glu Leu Gln Glu Lys Leu Ser Pro Leu 
    130                 135                 140                 


Gly Glu Glu Met Arg Asp Arg Ala Arg Ala His Val Asp Ala Leu Arg 
145                 150                 155                 160 


Thr His Leu Ala Pro Tyr Ser Asp Glu Leu Arg Gln Cys Leu Ala Ala 
                165                 170                 175     


Arg Leu Glu Ala Leu Lys Glu Asn Gly Gly Ala Arg Leu Ala Glu Tyr 
            180                 185                 190         


His Ala Lys Ala Thr Glu His Leu Ser Thr Leu Ser Glu Lys Ala Lys 
        195                 200                 205             


Pro Ala Leu Glu Asp Leu Arg Gln Gly Leu Leu Pro Val Leu Glu Ser 
    210                 215                 220                 


Phe Lys Val Ser Phe Leu Ser Ala Leu Glu Glu Tyr Thr Lys Lys Leu 
225                 230                 235                 240 


Asn Thr Gln 
            


<210>  23
<211>  732
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(732)
<223>  Mutein of human Apo A-1 

R61C, R215C

<400>  23
gat gaa ccc ccc cag agc ccc tgg gat cga gtg aag gac ctg gcc act       48
Asp Glu Pro Pro Gln Ser Pro Trp Asp Arg Val Lys Asp Leu Ala Thr         
1               5                   10                  15              

gtg tac gtg gat gtg ctc aaa gac agc ggc aga gac tat gtg tcc cag       96
Val Tyr Val Asp Val Leu Lys Asp Ser Gly Arg Asp Tyr Val Ser Gln         
            20                  25                  30                  

ttt gaa ggc tcc gcc ttg gga aaa cag cta aac cta aag ctc ctt gac      144
Phe Glu Gly Ser Ala Leu Gly Lys Gln Leu Asn Leu Lys Leu Leu Asp         
        35                  40                  45                      

aac tgg gac agc gtg acc tcc acc ttc agc aag ctg tgc gaa cag ctc      192
Asn Trp Asp Ser Val Thr Ser Thr Phe Ser Lys Leu Cys Glu Gln Leu         
    50                  55                  60                          

ggc cct gtg acc cag gag ttc tgg gat aac ctg gaa aag gag aca gag      240
Gly Pro Val Thr Gln Glu Phe Trp Asp Asn Leu Glu Lys Glu Thr Glu         
65                  70                  75                  80          

ggc ctg agg caa gag atg agc aag gat ctg gag gag gtg aag gcc aag      288
Gly Leu Arg Gln Glu Met Ser Lys Asp Leu Glu Glu Val Lys Ala Lys         
                85                  90                  95              

gtg cag ccc tac ctg gac gac ttc cag aag aag tgg cag gag gag atg      336
Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu Met         
            100                 105                 110                 

gag ctc tac cgc cag aag gtg gag ccg ctg cgc gca gag ctc caa gag      384
Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu Arg Ala Glu Leu Gln Glu         
        115                 120                 125                     

ggc gcg cgc cag aag ctg cac gag ctg caa gag aag ctg agc cca ctg      432
Gly Ala Arg Gln Lys Leu His Glu Leu Gln Glu Lys Leu Ser Pro Leu         
    130                 135                 140                         

ggc gag gag atg cgc gac cgc gcg cgc gcc cat gtg gac gcg ctg cgc      480
Gly Glu Glu Met Arg Asp Arg Ala Arg Ala His Val Asp Ala Leu Arg         
145                 150                 155                 160         

acg cat ctg gcc ccc tac agc gac gag ctg cgc cag cgc ttg gcc gcg      528
Thr His Leu Ala Pro Tyr Ser Asp Glu Leu Arg Gln Arg Leu Ala Ala         
                165                 170                 175             

cgc ctt gag gct ctc aag gag aac ggc ggc gcc aga ctg gcc gag tac      576
Arg Leu Glu Ala Leu Lys Glu Asn Gly Gly Ala Arg Leu Ala Glu Tyr         
            180                 185                 190                 

cac gcc aag gcc acc gag cat ctg agc acg ctc agc gag aag gcc aag      624
His Ala Lys Ala Thr Glu His Leu Ser Thr Leu Ser Glu Lys Ala Lys         
        195                 200                 205                     

ccc gcg ctc gag gac ctc tgc caa ggc ctg ctg ccc gtg ctg gag agc      672
Pro Ala Leu Glu Asp Leu Cys Gln Gly Leu Leu Pro Val Leu Glu Ser         
    210                 215                 220                         

ttc aag gtc agc ttc ctg agc gct ctc gag gag tac act aag aag ctc      720
Phe Lys Val Ser Phe Leu Ser Ala Leu Glu Glu Tyr Thr Lys Lys Leu         
225                 230                 235                 240         

aac acc cag tga                                                      732
Asn Thr Gln                                                             
                                                                        


<210>  24
<211>  243
<212>  PRT
<213>  Homo sapiens

<400>  24

Asp Glu Pro Pro Gln Ser Pro Trp Asp Arg Val Lys Asp Leu Ala Thr 
1               5                   10                  15      


Val Tyr Val Asp Val Leu Lys Asp Ser Gly Arg Asp Tyr Val Ser Gln 
            20                  25                  30          


Phe Glu Gly Ser Ala Leu Gly Lys Gln Leu Asn Leu Lys Leu Leu Asp 
        35                  40                  45              


Asn Trp Asp Ser Val Thr Ser Thr Phe Ser Lys Leu Cys Glu Gln Leu 
    50                  55                  60                  


Gly Pro Val Thr Gln Glu Phe Trp Asp Asn Leu Glu Lys Glu Thr Glu 
65                  70                  75                  80  


Gly Leu Arg Gln Glu Met Ser Lys Asp Leu Glu Glu Val Lys Ala Lys 
                85                  90                  95      


Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu Met 
            100                 105                 110         


Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu Arg Ala Glu Leu Gln Glu 
        115                 120                 125             


Gly Ala Arg Gln Lys Leu His Glu Leu Gln Glu Lys Leu Ser Pro Leu 
    130                 135                 140                 


Gly Glu Glu Met Arg Asp Arg Ala Arg Ala His Val Asp Ala Leu Arg 
145                 150                 155                 160 


Thr His Leu Ala Pro Tyr Ser Asp Glu Leu Arg Gln Arg Leu Ala Ala 
                165                 170                 175     


Arg Leu Glu Ala Leu Lys Glu Asn Gly Gly Ala Arg Leu Ala Glu Tyr 
            180                 185                 190         


His Ala Lys Ala Thr Glu His Leu Ser Thr Leu Ser Glu Lys Ala Lys 
        195                 200                 205             


Pro Ala Leu Glu Asp Leu Cys Gln Gly Leu Leu Pro Val Leu Glu Ser 
    210                 215                 220                 


Phe Lys Val Ser Phe Leu Ser Ala Leu Glu Glu Tyr Thr Lys Lys Leu 
225                 230                 235                 240 


Asn Thr Gln 
            


<210>  25
<211>  732
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(732)
<223>  Mutein of human Apo A-1 

R61C, R151C

<400>  25
gat gaa ccc ccc cag agc ccc tgg gat cga gtg aag gac ctg gcc act       48
Asp Glu Pro Pro Gln Ser Pro Trp Asp Arg Val Lys Asp Leu Ala Thr         
1               5                   10                  15              

gtg tac gtg gat gtg ctc aaa gac agc ggc aga gac tat gtg tcc cag       96
Val Tyr Val Asp Val Leu Lys Asp Ser Gly Arg Asp Tyr Val Ser Gln         
            20                  25                  30                  

ttt gaa ggc tcc gcc ttg gga aaa cag cta aac cta aag ctc ctt gac      144
Phe Glu Gly Ser Ala Leu Gly Lys Gln Leu Asn Leu Lys Leu Leu Asp         
        35                  40                  45                      

aac tgg gac agc gtg acc tcc acc ttc agc aag ctg tgc gaa cag ctc      192
Asn Trp Asp Ser Val Thr Ser Thr Phe Ser Lys Leu Cys Glu Gln Leu         
    50                  55                  60                          

ggc cct gtg acc cag gag ttc tgg gat aac ctg gaa aag gag aca gag      240
Gly Pro Val Thr Gln Glu Phe Trp Asp Asn Leu Glu Lys Glu Thr Glu         
65                  70                  75                  80          

ggc ctg agg caa gag atg agc aag gat ctg gag gag gtg aag gcc aag      288
Gly Leu Arg Gln Glu Met Ser Lys Asp Leu Glu Glu Val Lys Ala Lys         
                85                  90                  95              

gtg cag ccc tac ctg gac gac ttc cag aag aag tgg cag gag gag atg      336
Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu Met         
            100                 105                 110                 

gag ctc tac cgc cag aag gtg gag ccg ctg cgc gca gag ctc caa gag      384
Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu Arg Ala Glu Leu Gln Glu         
        115                 120                 125                     

ggc gcg cgc cag aag ctg cac gag ctg caa gag aag ctg agc cca ctg      432
Gly Ala Arg Gln Lys Leu His Glu Leu Gln Glu Lys Leu Ser Pro Leu         
    130                 135                 140                         

ggc gag gag atg cgc gac tgc gcg cgc gcc cat gtg gac gcg ctg cgc      480
Gly Glu Glu Met Arg Asp Cys Ala Arg Ala His Val Asp Ala Leu Arg         
145                 150                 155                 160         

acg cat ctg gcc ccc tac agc gac gag ctg cgc cag cgc ttg gcc gcg      528
Thr His Leu Ala Pro Tyr Ser Asp Glu Leu Arg Gln Arg Leu Ala Ala         
                165                 170                 175             

cgc ctt gag gct ctc aag gag aac ggc ggc gcc aga ctg gcc gag tac      576
Arg Leu Glu Ala Leu Lys Glu Asn Gly Gly Ala Arg Leu Ala Glu Tyr         
            180                 185                 190                 

cac gcc aag gcc acc gag cat ctg agc acg ctc agc gag aag gcc aag      624
His Ala Lys Ala Thr Glu His Leu Ser Thr Leu Ser Glu Lys Ala Lys         
        195                 200                 205                     

ccc gcg ctc gag gac ctc cgc caa ggc ctg ctg ccc gtg ctg gag agc      672
Pro Ala Leu Glu Asp Leu Arg Gln Gly Leu Leu Pro Val Leu Glu Ser         
    210                 215                 220                         

ttc aag gtc agc ttc ctg agc gct ctc gag gag tac act aag aag ctc      720
Phe Lys Val Ser Phe Leu Ser Ala Leu Glu Glu Tyr Thr Lys Lys Leu         
225                 230                 235                 240         

aac acc cag tga                                                      732
Asn Thr Gln                                                             
                                                                        


<210>  26
<211>  243
<212>  PRT
<213>  Homo sapiens

<400>  26

Asp Glu Pro Pro Gln Ser Pro Trp Asp Arg Val Lys Asp Leu Ala Thr 
1               5                   10                  15      


Val Tyr Val Asp Val Leu Lys Asp Ser Gly Arg Asp Tyr Val Ser Gln 
            20                  25                  30          


Phe Glu Gly Ser Ala Leu Gly Lys Gln Leu Asn Leu Lys Leu Leu Asp 
        35                  40                  45              


Asn Trp Asp Ser Val Thr Ser Thr Phe Ser Lys Leu Cys Glu Gln Leu 
    50                  55                  60                  


Gly Pro Val Thr Gln Glu Phe Trp Asp Asn Leu Glu Lys Glu Thr Glu 
65                  70                  75                  80  


Gly Leu Arg Gln Glu Met Ser Lys Asp Leu Glu Glu Val Lys Ala Lys 
                85                  90                  95      


Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu Met 
            100                 105                 110         


Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu Arg Ala Glu Leu Gln Glu 
        115                 120                 125             


Gly Ala Arg Gln Lys Leu His Glu Leu Gln Glu Lys Leu Ser Pro Leu 
    130                 135                 140                 


Gly Glu Glu Met Arg Asp Cys Ala Arg Ala His Val Asp Ala Leu Arg 
145                 150                 155                 160 


Thr His Leu Ala Pro Tyr Ser Asp Glu Leu Arg Gln Arg Leu Ala Ala 
                165                 170                 175     


Arg Leu Glu Ala Leu Lys Glu Asn Gly Gly Ala Arg Leu Ala Glu Tyr 
            180                 185                 190         


His Ala Lys Ala Thr Glu His Leu Ser Thr Leu Ser Glu Lys Ala Lys 
        195                 200                 205             


Pro Ala Leu Glu Asp Leu Arg Gln Gly Leu Leu Pro Val Leu Glu Ser 
    210                 215                 220                 


Phe Lys Val Ser Phe Leu Ser Ala Leu Glu Glu Tyr Thr Lys Lys Leu 
225                 230                 235                 240 


Asn Thr Gln 
            


<210>  27
<211>  732
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(732)
<223>  Mutein of human Apo A-1 

R83C, R173C

<400>  27
gat gaa ccc ccc cag agc ccc tgg gat cga gtg aag gac ctg gcc act       48
Asp Glu Pro Pro Gln Ser Pro Trp Asp Arg Val Lys Asp Leu Ala Thr         
1               5                   10                  15              

gtg tac gtg gat gtg ctc aaa gac agc ggc aga gac tat gtg tcc cag       96
Val Tyr Val Asp Val Leu Lys Asp Ser Gly Arg Asp Tyr Val Ser Gln         
            20                  25                  30                  

ttt gaa ggc tcc gcc ttg gga aaa cag cta aac cta aag ctc ctt gac      144
Phe Glu Gly Ser Ala Leu Gly Lys Gln Leu Asn Leu Lys Leu Leu Asp         
        35                  40                  45                      

aac tgg gac agc gtg acc tcc acc ttc agc aag ctg cgc gaa cag ctc      192
Asn Trp Asp Ser Val Thr Ser Thr Phe Ser Lys Leu Arg Glu Gln Leu         
    50                  55                  60                          

ggc cct gtg acc cag gag ttc tgg gat aac ctg gaa aag gag aca gag      240
Gly Pro Val Thr Gln Glu Phe Trp Asp Asn Leu Glu Lys Glu Thr Glu         
65                  70                  75                  80          

ggc ctg tgc caa gag atg agc aag gat ctg gag gag gtg aag gcc aag      288
Gly Leu Cys Gln Glu Met Ser Lys Asp Leu Glu Glu Val Lys Ala Lys         
                85                  90                  95              

gtg cag ccc tac ctg gac gac ttc cag aag aag tgg cag gag gag atg      336
Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu Met         
            100                 105                 110                 

gag ctc tac cgc cag aag gtg gag ccg ctg cgc gca gag ctc caa gag      384
Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu Arg Ala Glu Leu Gln Glu         
        115                 120                 125                     

ggc gcg cgc cag aag ctg cac gag ctg caa gag aag ctg agc cca ctg      432
Gly Ala Arg Gln Lys Leu His Glu Leu Gln Glu Lys Leu Ser Pro Leu         
    130                 135                 140                         

ggc gag gag atg cgc gac cgc gcg cgc gcc cat gtg gac gcg ctg cgc      480
Gly Glu Glu Met Arg Asp Arg Ala Arg Ala His Val Asp Ala Leu Arg         
145                 150                 155                 160         

acg cat ctg gcc ccc tac agc gac gag ctg cgc cag tgc ttg gcc gcg      528
Thr His Leu Ala Pro Tyr Ser Asp Glu Leu Arg Gln Cys Leu Ala Ala         
                165                 170                 175             

cgc ctt gag gct ctc aag gag aac ggc ggc gcc aga ctg gcc gag tac      576
Arg Leu Glu Ala Leu Lys Glu Asn Gly Gly Ala Arg Leu Ala Glu Tyr         
            180                 185                 190                 

cac gcc aag gcc acc gag cat ctg agc acg ctc agc gag aag gcc aag      624
His Ala Lys Ala Thr Glu His Leu Ser Thr Leu Ser Glu Lys Ala Lys         
        195                 200                 205                     

ccc gcg ctc gag gac ctc cgc caa ggc ctg ctg ccc gtg ctg gag agc      672
Pro Ala Leu Glu Asp Leu Arg Gln Gly Leu Leu Pro Val Leu Glu Ser         
    210                 215                 220                         

ttc aag gtc agc ttc ctg agc gct ctc gag gag tac act aag aag ctc      720
Phe Lys Val Ser Phe Leu Ser Ala Leu Glu Glu Tyr Thr Lys Lys Leu         
225                 230                 235                 240         

aac acc cag tga                                                      732
Asn Thr Gln                                                             
                                                                        


<210>  28
<211>  243
<212>  PRT
<213>  Homo sapiens

<400>  28

Asp Glu Pro Pro Gln Ser Pro Trp Asp Arg Val Lys Asp Leu Ala Thr 
1               5                   10                  15      


Val Tyr Val Asp Val Leu Lys Asp Ser Gly Arg Asp Tyr Val Ser Gln 
            20                  25                  30          


Phe Glu Gly Ser Ala Leu Gly Lys Gln Leu Asn Leu Lys Leu Leu Asp 
        35                  40                  45              


Asn Trp Asp Ser Val Thr Ser Thr Phe Ser Lys Leu Arg Glu Gln Leu 
    50                  55                  60                  


Gly Pro Val Thr Gln Glu Phe Trp Asp Asn Leu Glu Lys Glu Thr Glu 
65                  70                  75                  80  


Gly Leu Cys Gln Glu Met Ser Lys Asp Leu Glu Glu Val Lys Ala Lys 
                85                  90                  95      


Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu Met 
            100                 105                 110         


Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu Arg Ala Glu Leu Gln Glu 
        115                 120                 125             


Gly Ala Arg Gln Lys Leu His Glu Leu Gln Glu Lys Leu Ser Pro Leu 
    130                 135                 140                 


Gly Glu Glu Met Arg Asp Arg Ala Arg Ala His Val Asp Ala Leu Arg 
145                 150                 155                 160 


Thr His Leu Ala Pro Tyr Ser Asp Glu Leu Arg Gln Cys Leu Ala Ala 
                165                 170                 175     


Arg Leu Glu Ala Leu Lys Glu Asn Gly Gly Ala Arg Leu Ala Glu Tyr 
            180                 185                 190         


His Ala Lys Ala Thr Glu His Leu Ser Thr Leu Ser Glu Lys Ala Lys 
        195                 200                 205             


Pro Ala Leu Glu Asp Leu Arg Gln Gly Leu Leu Pro Val Leu Glu Ser 
    210                 215                 220                 


Phe Lys Val Ser Phe Leu Ser Ala Leu Glu Glu Tyr Thr Lys Lys Leu 
225                 230                 235                 240 


Asn Thr Gln 
            


<210>  29
<211>  732
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(732)
<223>  Mutein of human Apo A-1 

R83C, R151C

<400>  29
gat gaa ccc ccc cag agc ccc tgg gat cga gtg aag gac ctg gcc act       48
Asp Glu Pro Pro Gln Ser Pro Trp Asp Arg Val Lys Asp Leu Ala Thr         
1               5                   10                  15              

gtg tac gtg gat gtg ctc aaa gac agc ggc aga gac tat gtg tcc cag       96
Val Tyr Val Asp Val Leu Lys Asp Ser Gly Arg Asp Tyr Val Ser Gln         
            20                  25                  30                  

ttt gaa ggc tcc gcc ttg gga aaa cag cta aac cta aag ctc ctt gac      144
Phe Glu Gly Ser Ala Leu Gly Lys Gln Leu Asn Leu Lys Leu Leu Asp         
        35                  40                  45                      

aac tgg gac agc gtg acc tcc acc ttc agc aag ctg cgc gaa cag ctc      192
Asn Trp Asp Ser Val Thr Ser Thr Phe Ser Lys Leu Arg Glu Gln Leu         
    50                  55                  60                          

ggc cct gtg acc cag gag ttc tgg gat aac ctg gaa aag gag aca gag      240
Gly Pro Val Thr Gln Glu Phe Trp Asp Asn Leu Glu Lys Glu Thr Glu         
65                  70                  75                  80          

ggc ctg tgc caa gag atg agc aag gat ctg gag gag gtg aag gcc aag      288
Gly Leu Cys Gln Glu Met Ser Lys Asp Leu Glu Glu Val Lys Ala Lys         
                85                  90                  95              

gtg cag ccc tac ctg gac gac ttc cag aag aag tgg cag gag gag atg      336
Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu Met         
            100                 105                 110                 

gag ctc tac cgc cag aag gtg gag ccg ctg cgc gca gag ctc caa gag      384
Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu Arg Ala Glu Leu Gln Glu         
        115                 120                 125                     

ggc gcg cgc cag aag ctg cac gag ctg caa gag aag ctg agc cca ctg      432
Gly Ala Arg Gln Lys Leu His Glu Leu Gln Glu Lys Leu Ser Pro Leu         
    130                 135                 140                         

ggc gag gag atg cgc gac tgc gcg cgc gcc cat gtg gac gcg ctg cgc      480
Gly Glu Glu Met Arg Asp Cys Ala Arg Ala His Val Asp Ala Leu Arg         
145                 150                 155                 160         

acg cat ctg gcc ccc tac agc gac gag ctg cgc cag cgc ttg gcc gcg      528
Thr His Leu Ala Pro Tyr Ser Asp Glu Leu Arg Gln Arg Leu Ala Ala         
                165                 170                 175             

cgc ctt gag gct ctc aag gag aac ggc ggc gcc aga ctg gcc gag tac      576
Arg Leu Glu Ala Leu Lys Glu Asn Gly Gly Ala Arg Leu Ala Glu Tyr         
            180                 185                 190                 

cac gcc aag gcc acc gag cat ctg agc acg ctc agc gag aag gcc aag      624
His Ala Lys Ala Thr Glu His Leu Ser Thr Leu Ser Glu Lys Ala Lys         
        195                 200                 205                     

ccc gcg ctc gag gac ctc cgc caa ggc ctg ctg ccc gtg ctg gag agc      672
Pro Ala Leu Glu Asp Leu Arg Gln Gly Leu Leu Pro Val Leu Glu Ser         
    210                 215                 220                         

ttc aag gtc agc ttc ctg agc gct ctc gag gag tac act aag aag ctc      720
Phe Lys Val Ser Phe Leu Ser Ala Leu Glu Glu Tyr Thr Lys Lys Leu         
225                 230                 235                 240         

aac acc cag tga                                                      732
Asn Thr Gln                                                             
                                                                        


<210>  30
<211>  243
<212>  PRT
<213>  Homo sapiens

<400>  30

Asp Glu Pro Pro Gln Ser Pro Trp Asp Arg Val Lys Asp Leu Ala Thr 
1               5                   10                  15      


Val Tyr Val Asp Val Leu Lys Asp Ser Gly Arg Asp Tyr Val Ser Gln 
            20                  25                  30          


Phe Glu Gly Ser Ala Leu Gly Lys Gln Leu Asn Leu Lys Leu Leu Asp 
        35                  40                  45              


Asn Trp Asp Ser Val Thr Ser Thr Phe Ser Lys Leu Arg Glu Gln Leu 
    50                  55                  60                  


Gly Pro Val Thr Gln Glu Phe Trp Asp Asn Leu Glu Lys Glu Thr Glu 
65                  70                  75                  80  


Gly Leu Cys Gln Glu Met Ser Lys Asp Leu Glu Glu Val Lys Ala Lys 
                85                  90                  95      


Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu Met 
            100                 105                 110         


Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu Arg Ala Glu Leu Gln Glu 
        115                 120                 125             


Gly Ala Arg Gln Lys Leu His Glu Leu Gln Glu Lys Leu Ser Pro Leu 
    130                 135                 140                 


Gly Glu Glu Met Arg Asp Cys Ala Arg Ala His Val Asp Ala Leu Arg 
145                 150                 155                 160 


Thr His Leu Ala Pro Tyr Ser Asp Glu Leu Arg Gln Arg Leu Ala Ala 
                165                 170                 175     


Arg Leu Glu Ala Leu Lys Glu Asn Gly Gly Ala Arg Leu Ala Glu Tyr 
            180                 185                 190         


His Ala Lys Ala Thr Glu His Leu Ser Thr Leu Ser Glu Lys Ala Lys 
        195                 200                 205             


Pro Ala Leu Glu Asp Leu Arg Gln Gly Leu Leu Pro Val Leu Glu Ser 
    210                 215                 220                 


Phe Lys Val Ser Phe Leu Ser Ala Leu Glu Glu Tyr Thr Lys Lys Leu 
225                 230                 235                 240 


Asn Thr Gln 
            


<210>  31
<211>  732
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(732)
<223>  Mutein of human Apo A-1 

R83C, R215C

<400>  31
gat gaa ccc ccc cag agc ccc tgg gat cga gtg aag gac ctg gcc act       48
Asp Glu Pro Pro Gln Ser Pro Trp Asp Arg Val Lys Asp Leu Ala Thr         
1               5                   10                  15              

gtg tac gtg gat gtg ctc aaa gac agc ggc aga gac tat gtg tcc cag       96
Val Tyr Val Asp Val Leu Lys Asp Ser Gly Arg Asp Tyr Val Ser Gln         
            20                  25                  30                  

ttt gaa ggc tcc gcc ttg gga aaa cag cta aac cta aag ctc ctt gac      144
Phe Glu Gly Ser Ala Leu Gly Lys Gln Leu Asn Leu Lys Leu Leu Asp         
        35                  40                  45                      

aac tgg gac agc gtg acc tcc acc ttc agc aag ctg cgc gaa cag ctc      192
Asn Trp Asp Ser Val Thr Ser Thr Phe Ser Lys Leu Arg Glu Gln Leu         
    50                  55                  60                          

ggc cct gtg acc cag gag ttc tgg gat aac ctg gaa aag gag aca gag      240
Gly Pro Val Thr Gln Glu Phe Trp Asp Asn Leu Glu Lys Glu Thr Glu         
65                  70                  75                  80          

ggc ctg tgc caa gag atg agc aag gat ctg gag gag gtg aag gcc aag      288
Gly Leu Cys Gln Glu Met Ser Lys Asp Leu Glu Glu Val Lys Ala Lys         
                85                  90                  95              

gtg cag ccc tac ctg gac gac ttc cag aag aag tgg cag gag gag atg      336
Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu Met         
            100                 105                 110                 

gag ctc tac cgc cag aag gtg gag ccg ctg cgc gca gag ctc caa gag      384
Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu Arg Ala Glu Leu Gln Glu         
        115                 120                 125                     

ggc gcg cgc cag aag ctg cac gag ctg caa gag aag ctg agc cca ctg      432
Gly Ala Arg Gln Lys Leu His Glu Leu Gln Glu Lys Leu Ser Pro Leu         
    130                 135                 140                         

ggc gag gag atg cgc gac cgc gcg cgc gcc cat gtg gac gcg ctg cgc      480
Gly Glu Glu Met Arg Asp Arg Ala Arg Ala His Val Asp Ala Leu Arg         
145                 150                 155                 160         

acg cat ctg gcc ccc tac agc gac gag ctg cgc cag cgc ttg gcc gcg      528
Thr His Leu Ala Pro Tyr Ser Asp Glu Leu Arg Gln Arg Leu Ala Ala         
                165                 170                 175             

cgc ctt gag gct ctc aag gag aac ggc ggc gcc aga ctg gcc gag tac      576
Arg Leu Glu Ala Leu Lys Glu Asn Gly Gly Ala Arg Leu Ala Glu Tyr         
            180                 185                 190                 

cac gcc aag gcc acc gag cat ctg agc acg ctc agc gag aag gcc aag      624
His Ala Lys Ala Thr Glu His Leu Ser Thr Leu Ser Glu Lys Ala Lys         
        195                 200                 205                     

ccc gcg ctc gag gac ctc tgc caa ggc ctg ctg ccc gtg ctg gag agc      672
Pro Ala Leu Glu Asp Leu Cys Gln Gly Leu Leu Pro Val Leu Glu Ser         
    210                 215                 220                         

ttc aag gtc agc ttc ctg agc gct ctc gag gag tac act aag aag ctc      720
Phe Lys Val Ser Phe Leu Ser Ala Leu Glu Glu Tyr Thr Lys Lys Leu         
225                 230                 235                 240         

aac acc cag tga                                                      732
Asn Thr Gln                                                             
                                                                        


<210>  32
<211>  243
<212>  PRT
<213>  Homo sapiens

<400>  32

Asp Glu Pro Pro Gln Ser Pro Trp Asp Arg Val Lys Asp Leu Ala Thr 
1               5                   10                  15      


Val Tyr Val Asp Val Leu Lys Asp Ser Gly Arg Asp Tyr Val Ser Gln 
            20                  25                  30          


Phe Glu Gly Ser Ala Leu Gly Lys Gln Leu Asn Leu Lys Leu Leu Asp 
        35                  40                  45              


Asn Trp Asp Ser Val Thr Ser Thr Phe Ser Lys Leu Arg Glu Gln Leu 
    50                  55                  60                  


Gly Pro Val Thr Gln Glu Phe Trp Asp Asn Leu Glu Lys Glu Thr Glu 
65                  70                  75                  80  


Gly Leu Cys Gln Glu Met Ser Lys Asp Leu Glu Glu Val Lys Ala Lys 
                85                  90                  95      


Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu Met 
            100                 105                 110         


Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu Arg Ala Glu Leu Gln Glu 
        115                 120                 125             


Gly Ala Arg Gln Lys Leu His Glu Leu Gln Glu Lys Leu Ser Pro Leu 
    130                 135                 140                 


Gly Glu Glu Met Arg Asp Arg Ala Arg Ala His Val Asp Ala Leu Arg 
145                 150                 155                 160 


Thr His Leu Ala Pro Tyr Ser Asp Glu Leu Arg Gln Arg Leu Ala Ala 
                165                 170                 175     


Arg Leu Glu Ala Leu Lys Glu Asn Gly Gly Ala Arg Leu Ala Glu Tyr 
            180                 185                 190         


His Ala Lys Ala Thr Glu His Leu Ser Thr Leu Ser Glu Lys Ala Lys 
        195                 200                 205             


Pro Ala Leu Glu Asp Leu Cys Gln Gly Leu Leu Pro Val Leu Glu Ser 
    210                 215                 220                 


Phe Lys Val Ser Phe Leu Ser Ala Leu Glu Glu Tyr Thr Lys Lys Leu 
225                 230                 235                 240 


Asn Thr Gln 
            


<210>  33
<211>  732
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(732)
<223>  Mutein of human Apo A-1 

R151C, R173C

<400>  33
gat gaa ccc ccc cag agc ccc tgg gat cga gtg aag gac ctg gcc act       48
Asp Glu Pro Pro Gln Ser Pro Trp Asp Arg Val Lys Asp Leu Ala Thr         
1               5                   10                  15              

gtg tac gtg gat gtg ctc aaa gac agc ggc aga gac tat gtg tcc cag       96
Val Tyr Val Asp Val Leu Lys Asp Ser Gly Arg Asp Tyr Val Ser Gln         
            20                  25                  30                  

ttt gaa ggc tcc gcc ttg gga aaa cag cta aac cta aag ctc ctt gac      144
Phe Glu Gly Ser Ala Leu Gly Lys Gln Leu Asn Leu Lys Leu Leu Asp         
        35                  40                  45                      

aac tgg gac agc gtg acc tcc acc ttc agc aag ctg cgc gaa cag ctc      192
Asn Trp Asp Ser Val Thr Ser Thr Phe Ser Lys Leu Arg Glu Gln Leu         
    50                  55                  60                          

ggc cct gtg acc cag gag ttc tgg gat aac ctg gaa aag gag aca gag      240
Gly Pro Val Thr Gln Glu Phe Trp Asp Asn Leu Glu Lys Glu Thr Glu         
65                  70                  75                  80          

ggc ctg agg caa gag atg agc aag gat ctg gag gag gtg aag gcc aag      288
Gly Leu Arg Gln Glu Met Ser Lys Asp Leu Glu Glu Val Lys Ala Lys         
                85                  90                  95              

gtg cag ccc tac ctg gac gac ttc cag aag aag tgg cag gag gag atg      336
Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu Met         
            100                 105                 110                 

gag ctc tac cgc cag aag gtg gag ccg ctg cgc gca gag ctc caa gag      384
Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu Arg Ala Glu Leu Gln Glu         
        115                 120                 125                     

ggc gcg cgc cag aag ctg cac gag ctg caa gag aag ctg agc cca ctg      432
Gly Ala Arg Gln Lys Leu His Glu Leu Gln Glu Lys Leu Ser Pro Leu         
    130                 135                 140                         

ggc gag gag atg cgc gac tgc gcg cgc gcc cat gtg gac gcg ctg cgc      480
Gly Glu Glu Met Arg Asp Cys Ala Arg Ala His Val Asp Ala Leu Arg         
145                 150                 155                 160         

acg cat ctg gcc ccc tac agc gac gag ctg cgc cag tgc ttg gcc gcg      528
Thr His Leu Ala Pro Tyr Ser Asp Glu Leu Arg Gln Cys Leu Ala Ala         
                165                 170                 175             

cgc ctt gag gct ctc aag gag aac ggc ggc gcc aga ctg gcc gag tac      576
Arg Leu Glu Ala Leu Lys Glu Asn Gly Gly Ala Arg Leu Ala Glu Tyr         
            180                 185                 190                 

cac gcc aag gcc acc gag cat ctg agc acg ctc agc gag aag gcc aag      624
His Ala Lys Ala Thr Glu His Leu Ser Thr Leu Ser Glu Lys Ala Lys         
        195                 200                 205                     

ccc gcg ctc gag gac ctc cgc caa ggc ctg ctg ccc gtg ctg gag agc      672
Pro Ala Leu Glu Asp Leu Arg Gln Gly Leu Leu Pro Val Leu Glu Ser         
    210                 215                 220                         

ttc aag gtc agc ttc ctg agc gct ctc gag gag tac act aag aag ctc      720
Phe Lys Val Ser Phe Leu Ser Ala Leu Glu Glu Tyr Thr Lys Lys Leu         
225                 230                 235                 240         

aac acc cag tga                                                      732
Asn Thr Gln                                                             
                                                                        


<210>  34
<211>  243
<212>  PRT
<213>  Homo sapiens

<400>  34

Asp Glu Pro Pro Gln Ser Pro Trp Asp Arg Val Lys Asp Leu Ala Thr 
1               5                   10                  15      


Val Tyr Val Asp Val Leu Lys Asp Ser Gly Arg Asp Tyr Val Ser Gln 
            20                  25                  30          


Phe Glu Gly Ser Ala Leu Gly Lys Gln Leu Asn Leu Lys Leu Leu Asp 
        35                  40                  45              


Asn Trp Asp Ser Val Thr Ser Thr Phe Ser Lys Leu Arg Glu Gln Leu 
    50                  55                  60                  


Gly Pro Val Thr Gln Glu Phe Trp Asp Asn Leu Glu Lys Glu Thr Glu 
65                  70                  75                  80  


Gly Leu Arg Gln Glu Met Ser Lys Asp Leu Glu Glu Val Lys Ala Lys 
                85                  90                  95      


Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu Met 
            100                 105                 110         


Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu Arg Ala Glu Leu Gln Glu 
        115                 120                 125             


Gly Ala Arg Gln Lys Leu His Glu Leu Gln Glu Lys Leu Ser Pro Leu 
    130                 135                 140                 


Gly Glu Glu Met Arg Asp Cys Ala Arg Ala His Val Asp Ala Leu Arg 
145                 150                 155                 160 


Thr His Leu Ala Pro Tyr Ser Asp Glu Leu Arg Gln Cys Leu Ala Ala 
                165                 170                 175     


Arg Leu Glu Ala Leu Lys Glu Asn Gly Gly Ala Arg Leu Ala Glu Tyr 
            180                 185                 190         


His Ala Lys Ala Thr Glu His Leu Ser Thr Leu Ser Glu Lys Ala Lys 
        195                 200                 205             


Pro Ala Leu Glu Asp Leu Arg Gln Gly Leu Leu Pro Val Leu Glu Ser 
    210                 215                 220                 


Phe Lys Val Ser Phe Leu Ser Ala Leu Glu Glu Tyr Thr Lys Lys Leu 
225                 230                 235                 240 


Asn Thr Gln 
            


<210>  35
<211>  732
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(732)
<223>  Mutein of human Apo A-1 

R151C, R215C

<400>  35
gat gaa ccc ccc cag agc ccc tgg gat cga gtg aag gac ctg gcc act       48
Asp Glu Pro Pro Gln Ser Pro Trp Asp Arg Val Lys Asp Leu Ala Thr         
1               5                   10                  15              

gtg tac gtg gat gtg ctc aaa gac agc ggc aga gac tat gtg tcc cag       96
Val Tyr Val Asp Val Leu Lys Asp Ser Gly Arg Asp Tyr Val Ser Gln         
            20                  25                  30                  

ttt gaa ggc tcc gcc ttg gga aaa cag cta aac cta aag ctc ctt gac      144
Phe Glu Gly Ser Ala Leu Gly Lys Gln Leu Asn Leu Lys Leu Leu Asp         
        35                  40                  45                      

aac tgg gac agc gtg acc tcc acc ttc agc aag ctg cgc gaa cag ctc      192
Asn Trp Asp Ser Val Thr Ser Thr Phe Ser Lys Leu Arg Glu Gln Leu         
    50                  55                  60                          

ggc cct gtg acc cag gag ttc tgg gat aac ctg gaa aag gag aca gag      240
Gly Pro Val Thr Gln Glu Phe Trp Asp Asn Leu Glu Lys Glu Thr Glu         
65                  70                  75                  80          

ggc ctg agg caa gag atg agc aag gat ctg gag gag gtg aag gcc aag      288
Gly Leu Arg Gln Glu Met Ser Lys Asp Leu Glu Glu Val Lys Ala Lys         
                85                  90                  95              

gtg cag ccc tac ctg gac gac ttc cag aag aag tgg cag gag gag atg      336
Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu Met         
            100                 105                 110                 

gag ctc tac cgc cag aag gtg gag ccg ctg cgc gca gag ctc caa gag      384
Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu Arg Ala Glu Leu Gln Glu         
        115                 120                 125                     

ggc gcg cgc cag aag ctg cac gag ctg caa gag aag ctg agc cca ctg      432
Gly Ala Arg Gln Lys Leu His Glu Leu Gln Glu Lys Leu Ser Pro Leu         
    130                 135                 140                         

ggc gag gag atg cgc gac tgc gcg cgc gcc cat gtg gac gcg ctg cgc      480
Gly Glu Glu Met Arg Asp Cys Ala Arg Ala His Val Asp Ala Leu Arg         
145                 150                 155                 160         

acg cat ctg gcc ccc tac agc gac gag ctg cgc cag cgc ttg gcc gcg      528
Thr His Leu Ala Pro Tyr Ser Asp Glu Leu Arg Gln Arg Leu Ala Ala         
                165                 170                 175             

cgc ctt gag gct ctc aag gag aac ggc ggc gcc aga ctg gcc gag tac      576
Arg Leu Glu Ala Leu Lys Glu Asn Gly Gly Ala Arg Leu Ala Glu Tyr         
            180                 185                 190                 

cac gcc aag gcc acc gag cat ctg agc acg ctc agc gag aag gcc aag      624
His Ala Lys Ala Thr Glu His Leu Ser Thr Leu Ser Glu Lys Ala Lys         
        195                 200                 205                     

ccc gcg ctc gag gac ctc tgc caa ggc ctg ctg ccc gtg ctg gag agc      672
Pro Ala Leu Glu Asp Leu Cys Gln Gly Leu Leu Pro Val Leu Glu Ser         
    210                 215                 220                         

ttc aag gtc agc ttc ctg agc gct ctc gag gag tac act aag aag ctc      720
Phe Lys Val Ser Phe Leu Ser Ala Leu Glu Glu Tyr Thr Lys Lys Leu         
225                 230                 235                 240         

aac acc cag tga                                                      732
Asn Thr Gln                                                             
                                                                        


<210>  36
<211>  243
<212>  PRT
<213>  Homo sapiens

<400>  36

Asp Glu Pro Pro Gln Ser Pro Trp Asp Arg Val Lys Asp Leu Ala Thr 
1               5                   10                  15      


Val Tyr Val Asp Val Leu Lys Asp Ser Gly Arg Asp Tyr Val Ser Gln 
            20                  25                  30          


Phe Glu Gly Ser Ala Leu Gly Lys Gln Leu Asn Leu Lys Leu Leu Asp 
        35                  40                  45              


Asn Trp Asp Ser Val Thr Ser Thr Phe Ser Lys Leu Arg Glu Gln Leu 
    50                  55                  60                  


Gly Pro Val Thr Gln Glu Phe Trp Asp Asn Leu Glu Lys Glu Thr Glu 
65                  70                  75                  80  


Gly Leu Arg Gln Glu Met Ser Lys Asp Leu Glu Glu Val Lys Ala Lys 
                85                  90                  95      


Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu Met 
            100                 105                 110         


Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu Arg Ala Glu Leu Gln Glu 
        115                 120                 125             


Gly Ala Arg Gln Lys Leu His Glu Leu Gln Glu Lys Leu Ser Pro Leu 
    130                 135                 140                 


Gly Glu Glu Met Arg Asp Cys Ala Arg Ala His Val Asp Ala Leu Arg 
145                 150                 155                 160 


Thr His Leu Ala Pro Tyr Ser Asp Glu Leu Arg Gln Arg Leu Ala Ala 
                165                 170                 175     


Arg Leu Glu Ala Leu Lys Glu Asn Gly Gly Ala Arg Leu Ala Glu Tyr 
            180                 185                 190         


His Ala Lys Ala Thr Glu His Leu Ser Thr Leu Ser Glu Lys Ala Lys 
        195                 200                 205             


Pro Ala Leu Glu Asp Leu Cys Gln Gly Leu Leu Pro Val Leu Glu Ser 
    210                 215                 220                 


Phe Lys Val Ser Phe Leu Ser Ala Leu Glu Glu Tyr Thr Lys Lys Leu 
225                 230                 235                 240 


Asn Thr Gln 
            


<210>  37
<211>  732
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(732)
<223>  Mutein of human Apo A-1 

R10C, R173C

<400>  37
gat gaa ccc ccc cag agc ccc tgg gat tgt gtg aag gac ctg gcc act       48
Asp Glu Pro Pro Gln Ser Pro Trp Asp Cys Val Lys Asp Leu Ala Thr         
1               5                   10                  15              

gtg tac gtg gat gtg ctc aaa gac agc ggc aga gac tat gtg tcc cag       96
Val Tyr Val Asp Val Leu Lys Asp Ser Gly Arg Asp Tyr Val Ser Gln         
            20                  25                  30                  

ttt gaa ggc tcc gcc ttg gga aaa cag cta aac cta aag ctc ctt gac      144
Phe Glu Gly Ser Ala Leu Gly Lys Gln Leu Asn Leu Lys Leu Leu Asp         
        35                  40                  45                      

aac tgg gac agc gtg acc tcc acc ttc agc aag ctg cgc gaa cag ctc      192
Asn Trp Asp Ser Val Thr Ser Thr Phe Ser Lys Leu Arg Glu Gln Leu         
    50                  55                  60                          

ggc cct gtg acc cag gag ttc tgg gat aac ctg gaa aag gag aca gag      240
Gly Pro Val Thr Gln Glu Phe Trp Asp Asn Leu Glu Lys Glu Thr Glu         
65                  70                  75                  80          

ggc ctg agg caa gag atg agc aag gat ctg gag gag gtg aag gcc aag      288
Gly Leu Arg Gln Glu Met Ser Lys Asp Leu Glu Glu Val Lys Ala Lys         
                85                  90                  95              

gtg cag ccc tac ctg gac gac ttc cag aag aag tgg cag gag gag atg      336
Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu Met         
            100                 105                 110                 

gag ctc tac cgc cag aag gtg gag ccg ctg cgc gca gag ctc caa gag      384
Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu Arg Ala Glu Leu Gln Glu         
        115                 120                 125                     

ggc gcg cgc cag aag ctg cac gag ctg caa gag aag ctg agc cca ctg      432
Gly Ala Arg Gln Lys Leu His Glu Leu Gln Glu Lys Leu Ser Pro Leu         
    130                 135                 140                         

ggc gag gag atg cgc gac cgc gcg cgc gcc cat gtg gac gcg ctg cgc      480
Gly Glu Glu Met Arg Asp Arg Ala Arg Ala His Val Asp Ala Leu Arg         
145                 150                 155                 160         

acg cat ctg gcc ccc tac agc gac gag ctg cgc cag tgc ttg gcc gcg      528
Thr His Leu Ala Pro Tyr Ser Asp Glu Leu Arg Gln Cys Leu Ala Ala         
                165                 170                 175             

cgc ctt gag gct ctc aag gag aac ggc ggc gcc aga ctg gcc gag tac      576
Arg Leu Glu Ala Leu Lys Glu Asn Gly Gly Ala Arg Leu Ala Glu Tyr         
            180                 185                 190                 

cac gcc aag gcc acc gag cat ctg agc acg ctc agc gag aag gcc aag      624
His Ala Lys Ala Thr Glu His Leu Ser Thr Leu Ser Glu Lys Ala Lys         
        195                 200                 205                     

ccc gcg ctc gag gac ctc cgc caa ggc ctg ctg ccc gtg ctg gag agc      672
Pro Ala Leu Glu Asp Leu Arg Gln Gly Leu Leu Pro Val Leu Glu Ser         
    210                 215                 220                         

ttc aag gtc agc ttc ctg agc gct ctc gag gag tac act aag aag ctc      720
Phe Lys Val Ser Phe Leu Ser Ala Leu Glu Glu Tyr Thr Lys Lys Leu         
225                 230                 235                 240         

aac acc cag tga                                                      732
Asn Thr Gln                                                             
                                                                        


<210>  38
<211>  243
<212>  PRT
<213>  Homo sapiens

<400>  38

Asp Glu Pro Pro Gln Ser Pro Trp Asp Cys Val Lys Asp Leu Ala Thr 
1               5                   10                  15      


Val Tyr Val Asp Val Leu Lys Asp Ser Gly Arg Asp Tyr Val Ser Gln 
            20                  25                  30          


Phe Glu Gly Ser Ala Leu Gly Lys Gln Leu Asn Leu Lys Leu Leu Asp 
        35                  40                  45              


Asn Trp Asp Ser Val Thr Ser Thr Phe Ser Lys Leu Arg Glu Gln Leu 
    50                  55                  60                  


Gly Pro Val Thr Gln Glu Phe Trp Asp Asn Leu Glu Lys Glu Thr Glu 
65                  70                  75                  80  


Gly Leu Arg Gln Glu Met Ser Lys Asp Leu Glu Glu Val Lys Ala Lys 
                85                  90                  95      


Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu Met 
            100                 105                 110         


Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu Arg Ala Glu Leu Gln Glu 
        115                 120                 125             


Gly Ala Arg Gln Lys Leu His Glu Leu Gln Glu Lys Leu Ser Pro Leu 
    130                 135                 140                 


Gly Glu Glu Met Arg Asp Arg Ala Arg Ala His Val Asp Ala Leu Arg 
145                 150                 155                 160 


Thr His Leu Ala Pro Tyr Ser Asp Glu Leu Arg Gln Cys Leu Ala Ala 
                165                 170                 175     


Arg Leu Glu Ala Leu Lys Glu Asn Gly Gly Ala Arg Leu Ala Glu Tyr 
            180                 185                 190         


His Ala Lys Ala Thr Glu His Leu Ser Thr Leu Ser Glu Lys Ala Lys 
        195                 200                 205             


Pro Ala Leu Glu Asp Leu Arg Gln Gly Leu Leu Pro Val Leu Glu Ser 
    210                 215                 220                 


Phe Lys Val Ser Phe Leu Ser Ala Leu Glu Glu Tyr Thr Lys Lys Leu 
225                 230                 235                 240 


Asn Thr Gln 
            


<210>  39
<211>  30
<212>  DNA
<213>  artificial

<220>
<223>  primer for Apo A-1 Milano of seq id no 2 and muteins of seq id 
       no: 8, 22, 28, 34, 38

<400>  39
gacgagctgc gccagtgctt ggccgcgcgc                                      30


<210>  40
<211>  30
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  primer per Apo A-1 Mialno od seq id no 2 and for muteins of seq 
       id no: 8, 22, 28, 34, 38

<400>  40
gcgcgcggcc aagcactggc gcagctcgtc                                      30


<210>  41
<211>  34
<212>  DNA
<213>  artificial

<220>
<223>  primer for mutein of seq id no 4, 10

<400>  41
gaaggtggag ccgctgtgcg cagagctcca agag                                 34


<210>  42
<211>  34
<212>  DNA
<213>  artificial

<220>
<223>  Primer for mutein of seq id no 4, 10

<400>  42
ctcttggagc tctgcgcaca gcggctccac cttc                                 34


<210>  43
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  primer for mutein of seq id no 4, 8, 10, 20, 24, 32, 36

<400>  43
gcgctcgagg acctctgcca aggcctgctg ccc                                  33


<210>  44
<211>  33
<212>  DNA
<213>  artificial

<220>
<223>  primer for mutein of SEQ ID No 4, 8, 10, 20, 24, 32, 36

<400>  44
gggcagcagg ccttggcaga ggtcctcgag cgc                                  33


<210>  45
<211>  27
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  Primer for mutein of seq id no: 12, 20, 38

<400>  45
agcccctggg attgtgtgaa ggacctg                                         27


<210>  46
<211>  27
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  primer for mutein of seq id no: 12, 20, 38

<400>  46
caggtccttc acacaatccc aggggct                                         27


<210>  47
<211>  24
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  Primer for mutein of seq id no: 14, 22, 24, 26

<400>  47
ttcagcaagc tgtgcgaaca gctc                                            24


<210>  48
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  Primer for mutein of seq id: 14, 22, 24, 26

<400>  48
gagctgttcg cacagcttgc tgaa                                            24


<210>  49
<211>  24
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  Primer for mutein of seq id no: 16, 28, 30, 32, 34

<400>  49
acagagggcc tgtgccaaga gatg                                            24


<210>  50
<211>  24
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  Primer for mutein of seq id no: 16, 28, 30, 32, 34

<400>  50
catctcttgg cacaggccct ctgt                                            24


<210>  51
<211>  24
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  Primer for mutein of seq id no: 18, 26, 30, 36

<400>  51
gagatgcgcg actgcgcgcg cgcc                                            24


<210>  52
<211>  24
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  Primer for mutein of seq id no: 18, 26, 30, 36

<400>  52
ggcgcgcgcg cagtcgcgca tctc                                            24


<210>  53
<211>  25
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  Primer forward for generation of pGEM-APO plasmid

<400>  53
ggatccgatg aaccccccca gagcc                                           25


<210>  54
<211>  28
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  Primer reverse for generation of plasmid pGEM-APO

<400>  54
gatatctcac tgggtgttga gcttgtag                                        28


<210>  54
<211>  732
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(732)
<223>  Human Apo A-1 wild type

<400>  54
gat gaa ccc ccc cag agc ccc tgg gat cga gtg aag gac ctg gcc act       48
Asp Glu Pro Pro Gln Ser Pro Trp Asp Arg Val Lys Asp Leu Ala Thr         
1               5                   10                  15              

gtg tac gtg gat gtg ctc aaa gac agc ggc aga gac tat gtg tcc cag       96
Val Tyr Val Asp Val Leu Lys Asp Ser Gly Arg Asp Tyr Val Ser Gln         
            20                  25                  30                  

ttt gaa ggc tcc gcc ttg gga aaa cag cta aac cta aag ctc ctt gac      144
Phe Glu Gly Ser Ala Leu Gly Lys Gln Leu Asn Leu Lys Leu Leu Asp         
        35                  40                  45                      

aac tgg gac agc gtg acc tcc acc ttc agc aag ctg cgc gaa cag ctc      192
Asn Trp Asp Ser Val Thr Ser Thr Phe Ser Lys Leu Arg Glu Gln Leu         
    50                  55                  60                          

ggc cct gtg acc cag gag ttc tgg gat aac ctg gaa aag gag aca gag      240
Gly Pro Val Thr Gln Glu Phe Trp Asp Asn Leu Glu Lys Glu Thr Glu         
65                  70                  75                  80          

ggc ctg agg caa gag atg agc aag gat ctg gag gag gtg aag gcc aag      288
Gly Leu Arg Gln Glu Met Ser Lys Asp Leu Glu Glu Val Lys Ala Lys         
                85                  90                  95              

gtg cag ccc tac ctg gac gac ttc cag aag aag tgg cag gag gag atg      336
Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu Met         
            100                 105                 110                 

gag ctc tac cgc cag aag gtg gag ccg ctg cgc gca gag ctc caa gag      384
Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu Arg Ala Glu Leu Gln Glu         
        115                 120                 125                     

ggc gcg cgc cag aag ctg cac gag ctg caa gag aag ctg agc cca ctg      432
Gly Ala Arg Gln Lys Leu His Glu Leu Gln Glu Lys Leu Ser Pro Leu         
    130                 135                 140                         

ggc gag gag atg cgc gac cgc gcg cgc gcc cat gtg gac gcg ctg cgc      480
Gly Glu Glu Met Arg Asp Arg Ala Arg Ala His Val Asp Ala Leu Arg         
145                 150                 155                 160         

acg cat ctg gcc ccc tac agc gac gag ctg cgc cag cgc ttg gcc gcg      528
Thr His Leu Ala Pro Tyr Ser Asp Glu Leu Arg Gln Arg Leu Ala Ala         
                165                 170                 175             

cgc ctt gag gct ctc aag gag aac ggc ggc gcc aga ctg gcc gag tac      576
Arg Leu Glu Ala Leu Lys Glu Asn Gly Gly Ala Arg Leu Ala Glu Tyr         
            180                 185                 190                 

cac gcc aag gcc acc gag cat ctg agc acg ctc agc gag aag gcc aag      624
His Ala Lys Ala Thr Glu His Leu Ser Thr Leu Ser Glu Lys Ala Lys         
        195                 200                 205                     

ccc gcg ctc gag gac ctc cgc caa ggc ctg ctg ccc gtg ctg gag agc      672
Pro Ala Leu Glu Asp Leu Arg Gln Gly Leu Leu Pro Val Leu Glu Ser         
    210                 215                 220                         

ttc aag gtc agc ttc ctg agc gct ctc gag gag tac act aag aag ctc      720
Phe Lys Val Ser Phe Leu Ser Ala Leu Glu Glu Tyr Thr Lys Lys Leu         
225                 230                 235                 240         

aac acc cag tga                                                      732
Asn Thr Gln                                                             
                                                                        


<210>  56
<211>  243
<212>  PRT
<213>  Homo sapiens

<400>  56

Asp Glu Pro Pro Gln Ser Pro Trp Asp Arg Val Lys Asp Leu Ala Thr 
1               5                   10                  15      


Val Tyr Val Asp Val Leu Lys Asp Ser Gly Arg Asp Tyr Val Ser Gln 
            20                  25                  30          


Phe Glu Gly Ser Ala Leu Gly Lys Gln Leu Asn Leu Lys Leu Leu Asp 
        35                  40                  45              


Asn Trp Asp Ser Val Thr Ser Thr Phe Ser Lys Leu Arg Glu Gln Leu 
    50                  55                  60                  


Gly Pro Val Thr Gln Glu Phe Trp Asp Asn Leu Glu Lys Glu Thr Glu 
65                  70                  75                  80  


Gly Leu Arg Gln Glu Met Ser Lys Asp Leu Glu Glu Val Lys Ala Lys 
                85                  90                  95      


Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu Met 
            100                 105                 110         


Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu Arg Ala Glu Leu Gln Glu 
        115                 120                 125             


Gly Ala Arg Gln Lys Leu His Glu Leu Gln Glu Lys Leu Ser Pro Leu 
    130                 135                 140                 


Gly Glu Glu Met Arg Asp Arg Ala Arg Ala His Val Asp Ala Leu Arg 
145                 150                 155                 160 


Thr His Leu Ala Pro Tyr Ser Asp Glu Leu Arg Gln Arg Leu Ala Ala 
                165                 170                 175     


Arg Leu Glu Ala Leu Lys Glu Asn Gly Gly Ala Arg Leu Ala Glu Tyr 
            180                 185                 190         


His Ala Lys Ala Thr Glu His Leu Ser Thr Leu Ser Glu Lys Ala Lys 
        195                 200                 205             


Pro Ala Leu Glu Asp Leu Arg Gln Gly Leu Leu Pro Val Leu Glu Ser 
    210                 215                 220                 


Phe Lys Val Ser Phe Leu Ser Ala Leu Glu Glu Tyr Thr Lys Lys Leu 
225                 230                 235                 240 


Asn Thr Gln 
            


