                         SEQUENCE LISTING

<110>  Genizon BioSciences
 
<120>  Chrohn Disease Susceptibility Gene

<130>  GENI-018/01WO

<150>  US 60/833,261
<151>  2006-07-26

<150>  US 60/834,151
<151>  2006-07-31

<160>  277   

<170>  PatentIn version 3.3

<210>  1
<211>  5959
<212>  DNA
<213>  Homosapiens

<400>  1
atcttgtgtt gttgaggctg aggactgact ggggttctga gactccctgt cccggaccgc     60

agattatagt gggaccagtc tcattaggtt gaatctacag cctatgttgg tgttaaccca    120

ggtctcttag agcgttaaaa ggatctgaac aaagtctgct caaatctcct gctgtgaacc    180

agcagaattt ttgaacagag accacgtctc cacctcctgg gctccaacga ttctcccatc    240

ttggcctccc aaagcgctgg atttacaggt ttcttcacat ataaaaatct attgtaaaaa    300

tacggaaaag aatggcagcg gaaacgcaga cactgaactt tgggcctgaa tggctccgag    360

ctctgtccag tggtgggagt attacatccc ctcctctttc tccagcattg ccgaagtata    420

aattagcaga ttatcgttac ggcagagaag aaatgttagc acttttcctt aaagacaaca    480

agataccttc agaccttctg gataaagaat ttctgcctat cctccaggag gaaccccttc    540

caccattggc tctggtaccc tttacagaag aagaacagag aaacttttcc atgtctgtaa    600

atagtgctgc tgtcctgcga ttgacaggac gaggaggagg aggaacagtg gtgggggctc    660

ctagaggtcg aagttcttca agagggcgag gcagaggcag aggtgaatgt ggtttctacc    720

aaagaagttt tgatgaagta gagggtgttt ttggtcgagg aggtggcaga gaaatgcata    780

gatcgcagag ctgggaggaa aggggtgaca gacgttttga aaaaccagga cgaaaagatg    840

tagggagacc aaattttgag gaaggtggac caacatcagt agggagaaag catgaattta    900

tacgctcaga aagtgaaaat tggcgcatct ttagagagga acaaaatgga gaagatgaag    960

atggaggttg gcgactagct ggatcaagga gggatggaga gaggtggcga cctcacagtc   1020

ctgatggccc tcgttctgca ggctggcggg aacacatgga acgacgtcgg aggtttgagt   1080

ttgattttcg agatagagat gatgaacggg gttaccgaag ggttcgctct ggcagtggga   1140

gcatagatga tgacagggat agcttgcccg aatggtgctt agaggatgct gaagaagaaa   1200

tgggtacatt tgactcatct ggagcattcc tttctctaaa aaaagtacag aaagagccta   1260

ttccagaaga gcaggagatg gacttccggc ctgtggacga aggggaggag tgctctgact   1320

ctgagggtag ccataatgaa gaggccaaag aacccgataa gacaaataag aaagaaggag   1380

agaaaacaga tagagtagga gttgaagcta gtgaggaaac tccccagacc tcatcatcat   1440

ctgctagacc aggtactcct tcagaccatc agtctcagga agcatcacag tttgagagga   1500

aagatgaacc aaaaactgag caaacggaaa aagctgaaga ggagactcgg atggaaaata   1560

gtctaccagc caaagtgccc agcagagggg atgaaatggt tgctgatgtc cagcagcccc   1620

tgtcgcagat tccttcagat acagcctctc ctcttctcat acttccacct cctgttccca   1680

atcctagtcc tactctccgg ccagttgaaa caccagttgt aggtgctcct ggtatgggca   1740

gtgtttccac agaacctgat gatgaagaag gtctcaaaca tttggagcag caagctgaga   1800

aaatggtggc ttatctccaa gacagtgcac tagatgatga aagattggca tcaaaactgc   1860

aagagcacag agctaaagga gtgtcgattc cattgatgca tgaagcaatg cagaagtggt   1920

attacaaaga tcctcaggga gaaattcaag gtcccttcaa taatcaggag atggcagaat   1980

ggtttcaggc gggctatttt actatgtctt tattggtgaa gagagcgtgt gatgaaagct   2040

tccaacctct tggcgatatc atgaaaatgt ggggaagggt tcccttttct ccaggtccag   2100

ctccccctcc tcatatggga gagctggacc aggaacgact gaccaggcag caagaactca   2160

cagccttata ccagatgcag cacctgcagt accagcagtt tttaatacaa caacaatatg   2220

cacaggtttt ggcccaacag cagaaagcag cactgtcttc ccagcagcag cagcagttgg   2280

cacttcttct tcaacagttt cagaccttga agatgagaat atctgatcag aacatcattc   2340

cctcagtaac taggtctgtg tccgtgccag atactggctc tatctgggag cttcagccaa   2400

cagcttcaca gcctacagtt tgggaaggtg gtagtgtatg ggatcttcct ctggacacca   2460

cgacaccagg ccctgccctg gaacagcttc agcagctaga gaaggccaaa gctgcaaagc   2520

tagagcaaga gagaagagag gcagaaatga gggcaaaacg ggaagaggaa gagcgaaaga   2580

ggcaggaaga actccgaaga caacaggagg aaattcttcg gcgacagcag gaagaagaaa   2640

ggaaaaggcg agaggaagaa gaacttgccc gaaggaaaca ggaagaggct ctgcgtcgcc   2700

agcgggagca agaaattgca ttaaggcgac agcgagaaga ggaagaaaga cagcagcaag   2760

aagaagctct tagaagactg gaagagagga gaagagaaga ggaagaaagg cggaagcagg   2820

aagaattgtt acgcaaacag gaagaggagg ctgcaaaatg ggcccgggaa gaagaagaag   2880

cccagcgtcg attagaggag aaccggctgc ggatggaaga ggaggcagcc agactccggc   2940

atgaggaaga agaacggaag agaaaggagc tggaggtcca gcggcagaag gagttaatgc   3000

gccagaggca acagcagcaa gaggctctcc ggaggttgca gcagcagcag cagcaacaac   3060

agctggcgca gatgaagctt ccttcttctt caacgtgggg ccagcagtcc aatacaacag   3120

catgtcagtc ccaggccacg ctgtcgttgg ctgaaatcca aaaactagag gaagaacgag   3180

aacggcagct tcgagaagag caaaggcgcc agcagaggga gttgatgaaa gctcttcagc   3240

agcagcagca acagcaacag cagaaactct caggttgggg gaatgtcagc aaaccttcag   3300

gtaccacgaa atctcttctg gagatccagc aggaagaggc caggcaaatg caaaagcagc   3360

agcagcagca gcagcaacac cagcaaccaa acagagctcg taacaatacg cattccaacc   3420

tgcacaccag cattgggaat tctgtttggg gctctataaa tactggtcct cctaaccagt   3480

gggcatctga cctagtcagt agtatttgga gtaatgctga cactaaaaac tccaacatgg   3540

gattctggga tgatgcagtg aaagaggtgg gacctaggaa ttcaacaaat aaaaataaaa   3600

acaacgccag tctcagtaaa tctgtaggtg tgtctaaccg gcagaataag aaagtagaag   3660

aagaagaaaa gttgctgaag ctctttcagg gagtaaataa agcccaagat ggatttacgc   3720

agtggtgtga acagatgctt catgccctta atacggcaaa taacttggat gttcccacat   3780

ttgtttcttt cctgaaagaa gtagaatctc cttatgaggt ccatgattat atcagggcct   3840

atttaggaga tacttctgag gccaaggagt ttgccaagca gttccttgag cgccgtgcca   3900

aacagaaagc caaccagcag cgtcagcagc agcagctgcc acagcagcag cagcagcagc   3960

cgccacagca gccgccacag cagccacaac agcaggactc tgtgtggggg atgaaccaca   4020

gtacactcca ttcagtattt cagaccaatc aaagcaacaa ccaacaatcc aattttgagg   4080

ctgtgcagag tggcaagaag aagaaaaagc agaagatggt ccgagcagat cccagtttat   4140

taggattttc agtcaatgca tcatcggagc gactcaacat gggtgaaatc gagacgttgg   4200

atgactactg agcacctgcc agtggactgg ccatccctct cctgtctgcc gactatggag   4260

tctccacctt tggacacaac acttactcac catttactct ttatcactct gcaacaaatc   4320

acagaaccga tcatctcagg ctttttcttc tggccctttg tgtccaagat tctttaatcc   4380

atttttgttg gtgaacatct cagactatag ataagtggac tggaccctgt gtcttggggg   4440

tggcagttgg gattactccc caacaaggct gattttaggc agcatgtgtt cactgtgctg   4500

tgatttcatc tactgtctcc cagaaagtgt gttgggatcg gccattagca gcttgctttc   4560

tcttgtcact ttttttcttc tattttgttt tttcttcttc tttttccccc catcagggca   4620

aatggtctaa ctggtgcaat catgaagaga gttaatggtt aacagacatt ggccaataac   4680

aaaacacccc atggactgtg actcgagtat ccaacaggca gtcagagctc tcccggtctg   4740

aaagttgcat tgccactgct aactttggga ttgcatcaga gaggccctga gtggggttga   4800

gatgaggttg gtttggtttg atgttacaca ctcctcacct gttctttctg agtgtccttt   4860

ctctgaaagg atttatgttt ttcttcgtta gatagtgact tctgagcaag ctgatctccc   4920

ctggcatgct ccaacctgat tggacaaagg aagctctatg gcctgggaga gagactattc   4980

ttaatttttc tttcttacaa aaactgattt ttcccataaa tatttttact tcagaggact   5040

aggaccattt tgttttgggc ccttctgctg aaaatttgtc tcgtttaaga ggcagctaga   5100

atctttacca tatgtatgaa tttgtataat ttcatttttg gatagggata aacttttgct   5160

tctgataaaa gcctggaatt tcatctggtc ctcagagcat tgcgtgtgtg tcttgctgta   5220

gcccggaaaa ggttttgtgt aaagattctg ggatggcaag ttgtttgcct tttctgaaaa   5280

gagaacatac agaacctgtc catctttaag accttcatcc atggaatcta ctatacagga   5340

ggatgcagtg ggctggaggg gatgggcgaa aatgggagca ggaagcctgg cctggcttct   5400

ggtcatggcc tcctaaaacc ttaaacttca agtagaaatg tactcaagcc ctatttataa   5460

acaaatactt ttcctgcctc caccaaaccc ctacagaaca tcacctggaa ttgccactca   5520

cactgggttg gagtcattgg gcagctgtgc ctgtgcgaga ggtgctgtgg tctgggcagc   5580

ccctggaaaa gcacctttgc tgcctgtcat tgttgcctga agaaggctgg agttgctctg   5640

agagcagttt gggtttggag tattatattt ggcttctatt tttattattt tggatcacca   5700

ttctccctat cccttcttgc ctccctccct tctaaacatg tgtaataact atacagagac   5760

tgctacaaaa ttgtatatag tttttggatc aaatagcatg aggggagagg aaaccattaa   5820

aagttggggc tcctactctc ctttgctttg taaattcaaa agttgggggt gggtaagagg   5880

gatagttaaa atgtttacaa aactttaggc tccctcggaa cttttgccag tgtggaggaa   5940

aataaaaaag aacttaaat                                                5959


<210>  2
<211>  1299
<212>  PRT
<213>  Homosapiens

<400>  2

Met Ala Ala Glu Thr Gln Thr Leu Asn Phe Gly Pro Glu Trp Leu Arg 
1               5                   10                  15      


Ala Leu Ser Ser Gly Gly Ser Ile Thr Ser Pro Pro Leu Ser Pro Ala 
            20                  25                  30          


Leu Pro Lys Tyr Lys Leu Ala Asp Tyr Arg Tyr Gly Arg Glu Glu Met 
        35                  40                  45              


Leu Ala Leu Phe Leu Lys Asp Asn Lys Ile Pro Ser Asp Leu Leu Asp 
    50                  55                  60                  


Lys Glu Phe Leu Pro Ile Leu Gln Glu Glu Pro Leu Pro Pro Leu Ala 
65                  70                  75                  80  


Leu Val Pro Phe Thr Glu Glu Glu Gln Arg Asn Phe Ser Met Ser Val 
                85                  90                  95      


Asn Ser Ala Ala Val Leu Arg Leu Thr Gly Arg Gly Gly Gly Gly Thr 
            100                 105                 110         


Val Val Gly Ala Pro Arg Gly Arg Ser Ser Ser Arg Gly Arg Gly Arg 
        115                 120                 125             


Gly Arg Gly Glu Cys Gly Phe Tyr Gln Arg Ser Phe Asp Glu Val Glu 
    130                 135                 140                 


Gly Val Phe Gly Arg Gly Gly Gly Arg Glu Met His Arg Ser Gln Ser 
145                 150                 155                 160 


Trp Glu Glu Arg Gly Asp Arg Arg Phe Glu Lys Pro Gly Arg Lys Asp 
                165                 170                 175     


Val Gly Arg Pro Asn Phe Glu Glu Gly Gly Pro Thr Ser Val Gly Arg 
            180                 185                 190         


Lys His Glu Phe Ile Arg Ser Glu Ser Glu Asn Trp Arg Ile Phe Arg 
        195                 200                 205             


Glu Glu Gln Asn Gly Glu Asp Glu Asp Gly Gly Trp Arg Leu Ala Gly 
    210                 215                 220                 


Ser Arg Arg Asp Gly Glu Arg Trp Arg Pro His Ser Pro Asp Gly Pro 
225                 230                 235                 240 


Arg Ser Ala Gly Trp Arg Glu His Met Glu Arg Arg Arg Arg Phe Glu 
                245                 250                 255     


Phe Asp Phe Arg Asp Arg Asp Asp Glu Arg Gly Tyr Arg Arg Val Arg 
            260                 265                 270         


Ser Gly Ser Gly Ser Ile Asp Asp Asp Arg Asp Ser Leu Pro Glu Trp 
        275                 280                 285             


Cys Leu Glu Asp Ala Glu Glu Glu Met Gly Thr Phe Asp Ser Ser Gly 
    290                 295                 300                 


Ala Phe Leu Ser Leu Lys Lys Val Gln Lys Glu Pro Ile Pro Glu Glu 
305                 310                 315                 320 


Gln Glu Met Asp Phe Arg Pro Val Asp Glu Gly Glu Glu Cys Ser Asp 
                325                 330                 335     


Ser Glu Gly Ser His Asn Glu Glu Ala Lys Glu Pro Asp Lys Thr Asn 
            340                 345                 350         


Lys Lys Glu Gly Glu Lys Thr Asp Arg Val Gly Val Glu Ala Ser Glu 
        355                 360                 365             


Glu Thr Pro Gln Thr Ser Ser Ser Ser Ala Arg Pro Gly Thr Pro Ser 
    370                 375                 380                 


Asp His Gln Ser Gln Glu Ala Ser Gln Phe Glu Arg Lys Asp Glu Pro 
385                 390                 395                 400 


Lys Thr Glu Gln Thr Glu Lys Ala Glu Glu Glu Thr Arg Met Glu Asn 
                405                 410                 415     


Ser Leu Pro Ala Lys Val Pro Ser Arg Gly Asp Glu Met Val Ala Asp 
            420                 425                 430         


Val Gln Gln Pro Leu Ser Gln Ile Pro Ser Asp Thr Ala Ser Pro Leu 
        435                 440                 445             


Leu Ile Leu Pro Pro Pro Val Pro Asn Pro Ser Pro Thr Leu Arg Pro 
    450                 455                 460                 


Val Glu Thr Pro Val Val Gly Ala Pro Gly Met Gly Ser Val Ser Thr 
465                 470                 475                 480 


Glu Pro Asp Asp Glu Glu Gly Leu Lys His Leu Glu Gln Gln Ala Glu 
                485                 490                 495     


Lys Met Val Ala Tyr Leu Gln Asp Ser Ala Leu Asp Asp Glu Arg Leu 
            500                 505                 510         


Ala Ser Lys Leu Gln Glu His Arg Ala Lys Gly Val Ser Ile Pro Leu 
        515                 520                 525             


Met His Glu Ala Met Gln Lys Trp Tyr Tyr Lys Asp Pro Gln Gly Glu 
    530                 535                 540                 


Ile Gln Gly Pro Phe Asn Asn Gln Glu Met Ala Glu Trp Phe Gln Ala 
545                 550                 555                 560 


Gly Tyr Phe Thr Met Ser Leu Leu Val Lys Arg Ala Cys Asp Glu Ser 
                565                 570                 575     


Phe Gln Pro Leu Gly Asp Ile Met Lys Met Trp Gly Arg Val Pro Phe 
            580                 585                 590         


Ser Pro Gly Pro Ala Pro Pro Pro His Met Gly Glu Leu Asp Gln Glu 
        595                 600                 605             


Arg Leu Thr Arg Gln Gln Glu Leu Thr Ala Leu Tyr Gln Met Gln His 
    610                 615                 620                 


Leu Gln Tyr Gln Gln Phe Leu Ile Gln Gln Gln Tyr Ala Gln Val Leu 
625                 630                 635                 640 


Ala Gln Gln Gln Lys Ala Ala Leu Ser Ser Gln Gln Gln Gln Gln Leu 
                645                 650                 655     


Ala Leu Leu Leu Gln Gln Phe Gln Thr Leu Lys Met Arg Ile Ser Asp 
            660                 665                 670         


Gln Asn Ile Ile Pro Ser Val Thr Arg Ser Val Ser Val Pro Asp Thr 
        675                 680                 685             


Gly Ser Ile Trp Glu Leu Gln Pro Thr Ala Ser Gln Pro Thr Val Trp 
    690                 695                 700                 


Glu Gly Gly Ser Val Trp Asp Leu Pro Leu Asp Thr Thr Thr Pro Gly 
705                 710                 715                 720 


Pro Ala Leu Glu Gln Leu Gln Gln Leu Glu Lys Ala Lys Ala Ala Lys 
                725                 730                 735     


Leu Glu Gln Glu Arg Arg Glu Ala Glu Met Arg Ala Lys Arg Glu Glu 
            740                 745                 750         


Glu Glu Arg Lys Arg Gln Glu Glu Leu Arg Arg Gln Gln Glu Glu Ile 
        755                 760                 765             


Leu Arg Arg Gln Gln Glu Glu Glu Arg Lys Arg Arg Glu Glu Glu Glu 
    770                 775                 780                 


Leu Ala Arg Arg Lys Gln Glu Glu Ala Leu Arg Arg Gln Arg Glu Gln 
785                 790                 795                 800 


Glu Ile Ala Leu Arg Arg Gln Arg Glu Glu Glu Glu Arg Gln Gln Gln 
                805                 810                 815     


Glu Glu Ala Leu Arg Arg Leu Glu Glu Arg Arg Arg Glu Glu Glu Glu 
            820                 825                 830         


Arg Arg Lys Gln Glu Glu Leu Leu Arg Lys Gln Glu Glu Glu Ala Ala 
        835                 840                 845             


Lys Trp Ala Arg Glu Glu Glu Glu Ala Gln Arg Arg Leu Glu Glu Asn 
    850                 855                 860                 


Arg Leu Arg Met Glu Glu Glu Ala Ala Arg Leu Arg His Glu Glu Glu 
865                 870                 875                 880 


Glu Arg Lys Arg Lys Glu Leu Glu Val Gln Arg Gln Lys Glu Leu Met 
                885                 890                 895     


Arg Gln Arg Gln Gln Gln Gln Glu Ala Leu Arg Arg Leu Gln Gln Gln 
            900                 905                 910         


Gln Gln Gln Gln Gln Leu Ala Gln Met Lys Leu Pro Ser Ser Ser Thr 
        915                 920                 925             


Trp Gly Gln Gln Ser Asn Thr Thr Ala Cys Gln Ser Gln Ala Thr Leu 
    930                 935                 940                 


Ser Leu Ala Glu Ile Gln Lys Leu Glu Glu Glu Arg Glu Arg Gln Leu 
945                 950                 955                 960 


Arg Glu Glu Gln Arg Arg Gln Gln Arg Glu Leu Met Lys Ala Leu Gln 
                965                 970                 975     


Gln Gln Gln Gln Gln Gln Gln Gln Lys Leu Ser Gly Trp Gly Asn Val 
            980                 985                 990         


Ser Lys Pro Ser Gly Thr Thr Lys  Ser Leu Leu Glu Ile  Gln Gln Glu 
        995                 1000                 1005             


Glu Ala  Arg Gln Met Gln Lys  Gln Gln Gln Gln Gln  Gln Gln His 
    1010                 1015                 1020             


Gln Gln  Pro Asn Arg Ala Arg  Asn Asn Thr His Ser  Asn Leu His 
    1025                 1030                 1035             


Thr Ser  Ile Gly Asn Ser Val  Trp Gly Ser Ile Asn  Thr Gly Pro 
    1040                 1045                 1050             


Pro Asn  Gln Trp Ala Ser Asp  Leu Val Ser Ser Ile  Trp Ser Asn 
    1055                 1060                 1065             


Ala Asp  Thr Lys Asn Ser Asn  Met Gly Phe Trp Asp  Asp Ala Val 
    1070                 1075                 1080             


Lys Glu  Val Gly Pro Arg Asn  Ser Thr Asn Lys Asn  Lys Asn Asn 
    1085                 1090                 1095             


Ala Ser  Leu Ser Lys Ser Val  Gly Val Ser Asn Arg  Gln Asn Lys 
    1100                 1105                 1110             


Lys Val  Glu Glu Glu Glu Lys  Leu Leu Lys Leu Phe  Gln Gly Val 
    1115                 1120                 1125             


Asn Lys  Ala Gln Asp Gly Phe  Thr Gln Trp Cys Glu  Gln Met Leu 
    1130                 1135                 1140             


His Ala  Leu Asn Thr Ala Asn  Asn Leu Asp Val Pro  Thr Phe Val 
    1145                 1150                 1155             


Ser Phe  Leu Lys Glu Val Glu  Ser Pro Tyr Glu Val  His Asp Tyr 
    1160                 1165                 1170             


Ile Arg  Ala Tyr Leu Gly Asp  Thr Ser Glu Ala Lys  Glu Phe Ala 
    1175                 1180                 1185             


Lys Gln  Phe Leu Glu Arg Arg  Ala Lys Gln Lys Ala  Asn Gln Gln 
    1190                 1195                 1200             


Arg Gln  Gln Gln Gln Leu Pro  Gln Gln Gln Gln Gln  Gln Pro Pro 
    1205                 1210                 1215             


Gln Gln  Pro Pro Gln Gln Pro  Gln Gln Gln Asp Ser  Val Trp Gly 
    1220                 1225                 1230             


Met Asn  His Ser Thr Leu His  Ser Val Phe Gln Thr  Asn Gln Ser 
    1235                 1240                 1245             


Asn Asn  Gln Gln Ser Asn Phe  Glu Ala Val Gln Ser  Gly Lys Lys 
    1250                 1255                 1260             


Lys Lys  Lys Gln Lys Met Val  Arg Ala Asp Pro Ser  Leu Leu Gly 
    1265                 1270                 1275             


Phe Ser  Val Asn Ala Ser Ser  Glu Arg Leu Asn Met  Gly Glu Ile 
    1280                 1285                 1290             


Glu Thr  Leu Asp Asp Tyr 
    1295                 


<210>  3
<211>  2981
<212>  DNA
<213>  Homosapiens

<400>  3
agtctaagaa gagaacctac aaactagact tgtagattaa aattatctga tcaaaaaggc     60

agactctgta aatttcctta agacctacct tggcataaag gctgacccag caaaagaact    120

gagaaataca gcctgagatg gacagcagta attgcaaagt tattgctcct ctcctaagtc    180

aaagataccg gaggatggtc accaaggatg gccacagcac acttcaaatg gatggcgctc    240

aaagaggtct tgcatatctt cgagatgctt ggggaatcct aatggacatg cgctggcgtt    300

ggatgatgtt ggtcttttct gcttcttttg ttgtccactg gcttgtcttt gcagtgctct    360

ggtatgttct ggctgagatg aatggtgatc tggaactaga tcatgatgcc ccacctgaaa    420

accacactat ctgtgtcaag tatatcacca gtttcacagc tgcattctcc ttctccctgg    480

agacacaact cacaattggt tatggtacca tgttccccag tggtgactgt ccaagtgcaa    540

tcgccttact tgccatacaa atgctcctag gcctcatgct agaggctttt atcacaggtg    600

cttttgtggc gaagattgcc cggccaaaaa atcgagcttt ttcaattcgc tttactgaca    660

tagcagtagt agctcacatg gatggcaaac ctaatcttat cttccaagtg gccaacaccc    720

gacctagccc tctaaccagt gtccgggtct cagctgtact ctatcaggaa agagaaaatg    780

gcaaactcta ccagaccagt gtggatttcc accttgatgg catcagttct gacgaatgtc    840

cattcttcat ctttccacta acgtactatc actccattac accatcaagt cctctggcta    900

ctctgctcca gcatgaaaat ccttctcact ttgaattagt tgtattcctt tcagcaatgc    960

aggagggcac tggagaaata tgccaaagga ggacatccta cctacagtct gaaatcatgt   1020

tacatcactg ttttgcatct ctgttgaccc gaggttccaa atgtgaatat caaatcaaga   1080

tggagaattt tgacaagact gtccctgaat ttccaactcc tctggtttct aaaagcccaa   1140

acaggactga cctggatatc cacatcaatg gacaaagcat tgacaatttt cagatctctg   1200

aaacaggact gacagaataa gacttatcca ttttttaatg tattaaatac acccagccag   1260

ttatgcagct actttttctt tactgtatct catgttttct tttttcaatg ctaattatag   1320

ctctctacat cacggtaatc atgcctatgc ctacgtaaga atggctgagc taacaataca   1380

cattctggaa acataacact ctacattaca aagtttgtta cctgctgaaa tcaatgtaac   1440

tcaacttgac agacacttat acagaaatgt tgctggtgaa tttataagaa tgtggtatga   1500

tactagtaat gaaggcaaaa tggacagtga agtttaacac aactgaactc taagaaaatc   1560

aaccattaat ctctcatttt catctgcaaa ttgaagcaac agtttagttt caaacctagc   1620

tccctgggtg gaatgacgac ttcactatac ttagtgaata tcctttaaga gctgggattt   1680

ttttcaagac aacaaagatc attcatttgg ttctttatac tatgaaactt gagtaagtat   1740

tacctcctta atttttaaca actaagaaca aaaattaacg agaaaaacaa caaagtacag   1800

atttatacat aaacctaaaa gcatttgaac atgacaccag aacacataca tatatgttca   1860

cttatttgtg gcagaaggtg atcagataag ctccagccca aatggaacct gtggggtggt   1920

attttgcatt gcaaggagac gcaaaatttt attttaaaac tgtcctccat aataatcaaa   1980

cggtgattca tctaaatgac ttctagcaac ctaagtaaag acattcccct cctatgtatg   2040

attcatttga tcatataaaa catcatgatg gctctaattc ataaatacaa aaatatattt   2100

aagtctttat agatataaag ctttacttag atataacttg agtgagtagg gaaaaaaatc   2160

tacagtagat aaagcaaaag ataattaggc aacaaagcat tttcaaactc aaattcctgt   2220

ttccaacttc aaatagtttt ttctataaac acaaaatcag tgtttattca ccagtaggag   2280

gttggactag atgaactcta ttatttcttt ctaaatctaa tagtctataa aaattatgtt   2340

tcctctgttt tttattttat ctatgctaaa atgagccctt tcccttatgt ccagtttaag   2400

atgatcattt gcatgatttt catttcaata aaaaaaagag aaactgtcct taaaacaaaa   2460

caaaaaccaa aaaagtcacc ctatcaggtt tcaaacagat ttgtggctgt tcttttctga   2520

aatttccctt attcaggttt ctgtgggaaa aatgaaagat taaccttccc cactggtgat   2580

gacctaggca ggaatcatct cttgaaataa atactagctg agtaaaggca agcaggtgtg   2640

aagagcaggg ctcagcagca agtcacattt ttctactatt tgaccaaaag gaaaagaaaa   2700

taaagaagaa ctctggagtg gtctaagact gataatagca gaagaatatc aagaacacag   2760

aaacttaatt attgtgaact tttgctgttt gaaaatctta gacattcatt cttaagtaga   2820

aatcagacca acagattttc ccaacccaag actattgtaa cacataaaga cagcaagaat   2880

tcttatttct ataataaatt aacaagattc acctaacctt tgaaaataaa gtagtattga   2940

agacttaaaa aaaaaaaaaa aaaaaataaa aaaaaaaaaa a                       2981


<210>  4
<211>  360
<212>  PRT
<213>  Homosapiens

<400>  4

Met Asp Ser Ser Asn Cys Lys Val Ile Ala Pro Leu Leu Ser Gln Arg 
1               5                   10                  15      


Tyr Arg Arg Met Val Thr Lys Asp Gly His Ser Thr Leu Gln Met Asp 
            20                  25                  30          


Gly Ala Gln Arg Gly Leu Ala Tyr Leu Arg Asp Ala Trp Gly Ile Leu 
        35                  40                  45              


Met Asp Met Arg Trp Arg Trp Met Met Leu Val Phe Ser Ala Ser Phe 
    50                  55                  60                  


Val Val His Trp Leu Val Phe Ala Val Leu Trp Tyr Val Leu Ala Glu 
65                  70                  75                  80  


Met Asn Gly Asp Leu Glu Leu Asp His Asp Ala Pro Pro Glu Asn His 
                85                  90                  95      


Thr Ile Cys Val Lys Tyr Ile Thr Ser Phe Thr Ala Ala Phe Ser Phe 
            100                 105                 110         


Ser Leu Glu Thr Gln Leu Thr Ile Gly Tyr Gly Thr Met Phe Pro Ser 
        115                 120                 125             


Gly Asp Cys Pro Ser Ala Ile Ala Leu Leu Ala Ile Gln Met Leu Leu 
    130                 135                 140                 


Gly Leu Met Leu Glu Ala Phe Ile Thr Gly Ala Phe Val Ala Lys Ile 
145                 150                 155                 160 


Ala Arg Pro Lys Asn Arg Ala Phe Ser Ile Arg Phe Thr Asp Ile Ala 
                165                 170                 175     


Val Val Ala His Met Asp Gly Lys Pro Asn Leu Ile Phe Gln Val Ala 
            180                 185                 190         


Asn Thr Arg Pro Ser Pro Leu Thr Ser Val Arg Val Ser Ala Val Leu 
        195                 200                 205             


Tyr Gln Glu Arg Glu Asn Gly Lys Leu Tyr Gln Thr Ser Val Asp Phe 
    210                 215                 220                 


His Leu Asp Gly Ile Ser Ser Asp Glu Cys Pro Phe Phe Ile Phe Pro 
225                 230                 235                 240 


Leu Thr Tyr Tyr His Ser Ile Thr Pro Ser Ser Pro Leu Ala Thr Leu 
                245                 250                 255     


Leu Gln His Glu Asn Pro Ser His Phe Glu Leu Val Val Phe Leu Ser 
            260                 265                 270         


Ala Met Gln Glu Gly Thr Gly Glu Ile Cys Gln Arg Arg Thr Ser Tyr 
        275                 280                 285             


Leu Gln Ser Glu Ile Met Leu His His Cys Phe Ala Ser Leu Leu Thr 
    290                 295                 300                 


Arg Gly Ser Lys Cys Glu Tyr Gln Ile Lys Met Glu Asn Phe Asp Lys 
305                 310                 315                 320 


Thr Val Pro Glu Phe Pro Thr Pro Leu Val Ser Lys Ser Pro Asn Arg 
                325                 330                 335     


Thr Asp Leu Asp Ile His Ile Asn Gly Gln Ser Ile Asp Asn Phe Gln 
            340                 345                 350         


Ile Ser Glu Thr Gly Leu Thr Glu 
        355                 360 


<210>  5
<211>  480
<212>  DNA
<213>  Homosapiens

<400>  5
gttaaccagc gcagtcctcc gtgcgtcccg cccgccgctg ccctcactcc cggccaggat     60

ggcatcctgt ctggccctgc gcatggcgct gctgctggtc tccggggttc tggcccctgc    120

ggtgctcaca gacgatgttc cacaggagcc cgtgcccacg ctgtggaacg agccggccga    180

gctgccgtcg ggagaaggcc ccgtggagag caccagcccc ggccgggagc ccgtggacac    240

cggtccccca gcccccaccg tcgcgccagg acccgaggac agcaccgcgc aggagcggct    300

ggaccagggc ggcgggtcgc tggggcccgg cgctatcgcg gccatcgtga tcgccgccct    360

gctggccacc tgcgtggtgc tggcgctcgt ggtcgtcgcg ctgagaaagt tttctgcctc    420

ctgaagcgaa taaaggggcc gcgcccggcc gcggcgcgac tcggcaaaaa aaaaaaaaaa    480


<210>  6
<211>  121
<212>  PRT
<213>  Homosapiens

<400>  6

Met Ala Ser Cys Leu Ala Leu Arg Met Ala Leu Leu Leu Val Ser Gly 
1               5                   10                  15      


Val Leu Ala Pro Ala Val Leu Thr Asp Asp Val Pro Gln Glu Pro Val 
            20                  25                  30          


Pro Thr Leu Trp Asn Glu Pro Ala Glu Leu Pro Ser Gly Glu Gly Pro 
        35                  40                  45              


Val Glu Ser Thr Ser Pro Gly Arg Glu Pro Val Asp Thr Gly Pro Pro 
    50                  55                  60                  


Ala Pro Thr Val Ala Pro Gly Pro Glu Asp Ser Thr Ala Gln Glu Arg 
65                  70                  75                  80  


Leu Asp Gln Gly Gly Gly Ser Leu Gly Pro Gly Ala Ile Ala Ala Ile 
                85                  90                  95      


Val Ile Ala Ala Leu Leu Ala Thr Cys Val Val Leu Ala Leu Val Val 
            100                 105                 110         


Val Ala Leu Arg Lys Phe Ser Ala Ser 
        115                 120     


<210>  7
<211>  3177
<212>  DNA
<213>  Homosapiens

<400>  7
caggacgaag tttttggctg tgggctctct gggacagagt ggagcgcctg tggatttagc     60

cggggacaca ccatcctgct cgcaggtgcc tggacaggac aggggacgag ggaggaacac    120

tctctgagga agcccaactc ctatgagctc ctctctggca gcactcaaac cagtgaagct    180

tgggaaagtc attgacctcc agtcgttctg ctgagaaaca tctggctcta tttccatgga    240

gaccagggaa tctgaagatt tggaaaagac ccggaggaaa tcagcaagtg atcaatggaa    300

cactgataat gaaccagcca aggtgaaacc tgagttactc ccagaaaaag aggagacttc    360

tcaagctgac caggatatcc aagacaaaga gcctcattgc cacatcccaa ttaagagaaa    420

ttccatcttc aatcgctcca taagacgcaa aagcaaagcc aaggccagag acaaccccga    480

acggaacgcc agctgcctgg cagattcaca ggacaatgga aaatctgtaa atgagcccct    540

gaccttgaat atcccctgga gcagaacgcc tccttgcaga acagcaatgc agacagaccc    600

aggagcccag gaaatgagtg agtcgtcctc caccccggga aatggggcca cgcccgagga    660

gtggccggcc ctggccgaca gccccaccac gctcaccgag gccctgcgga tgatccaccc    720

cattcccgcc gactcctgga gaaacctcat tgaacaaata gggctcctgt atcaggaata    780

ccgagataaa tcgactctcc aagaaatcga aaccaggagg caacaggatg cagaaataga    840

agacaatacc aatgggtccc cggccagtga ggacaccccg gaggaggaag aagaagagga    900

ggaggaggag gagccggcca gcccaccaga gaggaagact ctgccccaga tctgcctgct    960

cagtaacccc cactcaaggt tcaacctctg gcaggatctt cccgagatcc ggagcagcgg   1020

ggtgcttgag atcctacagc ctgaggagat taagctgcag gaggccatgt tcgagctggt   1080

cacttccgag gcgtcctact acaagagtct gaacctgctc gtgtcccact tcatggagaa   1140

cgagcggata aggaagatcc tgcacccgtc cgaggcgcac atcctcttct ccaacgtcct   1200

ggacgtgctg gctgtcagtg agcggttcct cctggagctg gagcaccgga tggaggagaa   1260

catcgtcatc tctgacgtgt gtgacatcgt gtaccgttat gcggctgacc acttctctgt   1320

ctacatcacc tacgtcagca atcagaccta ccaggagcgg acctataagc agctgctcca   1380

ggagaaggca gctttccggg agctgatcgc gcagctagag ctcgacccca agtgcagggg   1440

gctgcccttc tcctccttcc tcatcctgcc tttccagagg atcacacgcc tcaagctgtt   1500

ggtccagaac atcctgaaga gggtagaaga gaggtctgag cgggagtgca ctgctttgga   1560

tgctcacaag gagctggaaa tggtggtgaa ggcatgcaac gagggcgtca ggaaaatgag   1620

ccgcacggaa cagatgatca gcattcagaa gaagatggag ttcaagatca agtcggtgcc   1680

catcatctcc cactcccgct ggctgctgaa gcagggtgag ctgcagcaga tgtcaggccc   1740

caagacctcc cggaccctga ggaccaagaa gctcttccac gaaatttacc tcttcctgtt   1800

caacgacctg ctggtgatct gccggcagat tccaggagac aagtaccagg tatttgactc   1860

agctccgcgg ggactgctgc gtgtggagga gctggaggac cagggccaga cgctggccaa   1920

cgtgttcatc ctgcggctgc tggagaacgc agatgaccgg gaggccacct acatgctaaa   1980

ggcgtcctct cagagtgaga tgaagcgttg gatgacctca ctggccccca acaggaggac   2040

caagtttgtt tcgttcacat cccggctgct ggactgcccc caggtccagt gcgtgcaccc   2100

atacgtggct cagcagccag acgagctgac gctggagctc gccgacatcc tcaacatcct   2160

ggacaagact gacgacgggt ggatctttgg cgagcgtctg cacgaccagg agagaggctg   2220

gttccccagc tccatgactg aggagatctt gaatcccaag atccggtccc agaacctcaa   2280

ggaatgtttc cgtgtccaca agatggatga ccctcagcgc agccagaaca aggaccgcag   2340

gaagctgggc agccggaatc ggcaatgacc cccacccagg gggccagcgg gagcagggcc   2400

tgcatgagac cccgacagaa ggtggggggg gggcctctgg gaagcacagg ccagcacctc   2460

cccaggtggc aggatctggc ttggggtgcc cggccctcat ccctgcccac gcagtgagtg   2520

ctcatgtgtc ttggcccctt gcttgcaaac tggataaagg gtgcccaagc ctctcctgat   2580

gcatttgtaa acaagaaggt ttcagcagta ttacaccacc tccctcatgc ctccgagggg   2640

gtggaagggg gtgggcacac tccagggccc cccatgcccc tggcccccag ggactggaag   2700

aggctcccaa cccagagtgt ccctgtggga ggcaggcaga aggtgacaat tgacacgatt   2760

tcctgcacgc gtcctcctct accttggaag cagttagaat ctaccaggca cagatgaggc   2820

cgcccttgcc tgacggagct tgatgagcag cccttggtct ccggttccag gactgagagc   2880

ccagctgcct ctgcccaccc ttccccaggc ctctgccagc ctctggctgc acggtcaggc   2940

cctgccccat ggcaggcctg ccagagcttg gctggggacc cctcccgcct ctggctccct   3000

gatgggctgg atgtaacttg tgtcttctag ccgcttaagg agcccaggtg ttttaaggaa   3060

tgaattggtc actgcatctt gtatcgatta tggttctgag aaaagcaaat atcacttttg   3120

gctgcattaa aagaagcatc atatataaaa taaaaaaaaa aaaaaaaaaa aaaaaaa      3177


<210>  8
<211>  710
<212>  PRT
<213>  Homosapiens

<400>  8

Met Glu Thr Arg Glu Ser Glu Asp Leu Glu Lys Thr Arg Arg Lys Ser 
1               5                   10                  15      


Ala Ser Asp Gln Trp Asn Thr Asp Asn Glu Pro Ala Lys Val Lys Pro 
            20                  25                  30          


Glu Leu Leu Pro Glu Lys Glu Glu Thr Ser Gln Ala Asp Gln Asp Ile 
        35                  40                  45              


Gln Asp Lys Glu Pro His Cys His Ile Pro Ile Lys Arg Asn Ser Ile 
    50                  55                  60                  


Phe Asn Arg Ser Ile Arg Arg Lys Ser Lys Ala Lys Ala Arg Asp Asn 
65                  70                  75                  80  


Pro Glu Arg Asn Ala Ser Cys Leu Ala Asp Ser Gln Asp Asn Gly Lys 
                85                  90                  95      


Ser Val Asn Glu Pro Leu Thr Leu Asn Ile Pro Trp Ser Arg Thr Pro 
            100                 105                 110         


Pro Cys Arg Thr Ala Met Gln Thr Asp Pro Gly Ala Gln Glu Met Ser 
        115                 120                 125             


Glu Ser Ser Ser Thr Pro Gly Asn Gly Ala Thr Pro Glu Glu Trp Pro 
    130                 135                 140                 


Ala Leu Ala Asp Ser Pro Thr Thr Leu Thr Glu Ala Leu Arg Met Ile 
145                 150                 155                 160 


His Pro Ile Pro Ala Asp Ser Trp Arg Asn Leu Ile Glu Gln Ile Gly 
                165                 170                 175     


Leu Leu Tyr Gln Glu Tyr Arg Asp Lys Ser Thr Leu Gln Glu Ile Glu 
            180                 185                 190         


Thr Arg Arg Gln Gln Asp Ala Glu Ile Glu Asp Asn Thr Asn Gly Ser 
        195                 200                 205             


Pro Ala Ser Glu Asp Thr Pro Glu Glu Glu Glu Glu Glu Glu Glu Glu 
    210                 215                 220                 


Glu Glu Pro Ala Ser Pro Pro Glu Arg Lys Thr Leu Pro Gln Ile Cys 
225                 230                 235                 240 


Leu Leu Ser Asn Pro His Ser Arg Phe Asn Leu Trp Gln Asp Leu Pro 
                245                 250                 255     


Glu Ile Arg Ser Ser Gly Val Leu Glu Ile Leu Gln Pro Glu Glu Ile 
            260                 265                 270         


Lys Leu Gln Glu Ala Met Phe Glu Leu Val Thr Ser Glu Ala Ser Tyr 
        275                 280                 285             


Tyr Lys Ser Leu Asn Leu Leu Val Ser His Phe Met Glu Asn Glu Arg 
    290                 295                 300                 


Ile Arg Lys Ile Leu His Pro Ser Glu Ala His Ile Leu Phe Ser Asn 
305                 310                 315                 320 


Val Leu Asp Val Leu Ala Val Ser Glu Arg Phe Leu Leu Glu Leu Glu 
                325                 330                 335     


His Arg Met Glu Glu Asn Ile Val Ile Ser Asp Val Cys Asp Ile Val 
            340                 345                 350         


Tyr Arg Tyr Ala Ala Asp His Phe Ser Val Tyr Ile Thr Tyr Val Ser 
        355                 360                 365             


Asn Gln Thr Tyr Gln Glu Arg Thr Tyr Lys Gln Leu Leu Gln Glu Lys 
    370                 375                 380                 


Ala Ala Phe Arg Glu Leu Ile Ala Gln Leu Glu Leu Asp Pro Lys Cys 
385                 390                 395                 400 


Arg Gly Leu Pro Phe Ser Ser Phe Leu Ile Leu Pro Phe Gln Arg Ile 
                405                 410                 415     


Thr Arg Leu Lys Leu Leu Val Gln Asn Ile Leu Lys Arg Val Glu Glu 
            420                 425                 430         


Arg Ser Glu Arg Glu Cys Thr Ala Leu Asp Ala His Lys Glu Leu Glu 
        435                 440                 445             


Met Val Val Lys Ala Cys Asn Glu Gly Val Arg Lys Met Ser Arg Thr 
    450                 455                 460                 


Glu Gln Met Ile Ser Ile Gln Lys Lys Met Glu Phe Lys Ile Lys Ser 
465                 470                 475                 480 


Val Pro Ile Ile Ser His Ser Arg Trp Leu Leu Lys Gln Gly Glu Leu 
                485                 490                 495     


Gln Gln Met Ser Gly Pro Lys Thr Ser Arg Thr Leu Arg Thr Lys Lys 
            500                 505                 510         


Leu Phe His Glu Ile Tyr Leu Phe Leu Phe Asn Asp Leu Leu Val Ile 
        515                 520                 525             


Cys Arg Gln Ile Pro Gly Asp Lys Tyr Gln Val Phe Asp Ser Ala Pro 
    530                 535                 540                 


Arg Gly Leu Leu Arg Val Glu Glu Leu Glu Asp Gln Gly Gln Thr Leu 
545                 550                 555                 560 


Ala Asn Val Phe Ile Leu Arg Leu Leu Glu Asn Ala Asp Asp Arg Glu 
                565                 570                 575     


Ala Thr Tyr Met Leu Lys Ala Ser Ser Gln Ser Glu Met Lys Arg Trp 
            580                 585                 590         


Met Thr Ser Leu Ala Pro Asn Arg Arg Thr Lys Phe Val Ser Phe Thr 
        595                 600                 605             


Ser Arg Leu Leu Asp Cys Pro Gln Val Gln Cys Val His Pro Tyr Val 
    610                 615                 620                 


Ala Gln Gln Pro Asp Glu Leu Thr Leu Glu Leu Ala Asp Ile Leu Asn 
625                 630                 635                 640 


Ile Leu Asp Lys Thr Asp Asp Gly Trp Ile Phe Gly Glu Arg Leu His 
                645                 650                 655     


Asp Gln Glu Arg Gly Trp Phe Pro Ser Ser Met Thr Glu Glu Ile Leu 
            660                 665                 670         


Asn Pro Lys Ile Arg Ser Gln Asn Leu Lys Glu Cys Phe Arg Val His 
        675                 680                 685             


Lys Met Asp Asp Pro Gln Arg Ser Gln Asn Lys Asp Arg Arg Lys Leu 
    690                 695                 700                 


Gly Ser Arg Asn Arg Gln 
705                 710 


<210>  9
<211>  1143
<212>  DNA
<213>  Homosapiens

<400>  9
atggcgtccc ttcctgtcct gcagaaggag agcgtgttcc agtcgggagc ccatgcctac     60

agaatccctg ccctgctcta cctgcctggg cagcagtccc tgctggcctt cgcggaacag    120

cgggcaagca agaaggatga gcacgcagag ctgattgtcc tgcgcagagg agactacgac    180

gcacccaccc accaggttca gtggcaagct caggaggtgg tggcccaggc ccggctggat    240

ggccaccggt ccatgaaccc atgccccttg tatgacgcgc agacggggac cctcttcctc    300

ttcttcattg ccatccctgg gcaagtcacg gagcaacagc agctgcagac cagggccaat    360

gtgacgcggc tgtgccaagt caccagcact gaccacggga ggacctggag ctcccccaga    420

gacctcactg atgcggccat cggcccagcc taccgggagt ggtccacctt tgcagtgggc    480

ccggggcatt gtttgcagct taacgacagg gcccggagcc tggtggtgcc cgcctacgcc    540

taccggaaac ttcaccccat ccaaaggccg atcccctctg ccttctgctt cctcagccat    600

gaccatgggc gcacgtgggc gcgagggcac tttgtggccc aggacaccct ggagtgccag    660

gtggccgaag tcgagactgg ggagcagagg gtggtgaccc tcaacgcgag aagccacctc    720

cgagccaggg tccaggccca gagcaccaat gacgggcttg atttccagga gtctcagctg    780

gtgaagaagc tggtggagcc gccgccccag ggctgccagg ggagcgtcat cagcttcccc    840

agcccccgct cggggcctgg ctccccagcc cagtggctgc tctacactca ccccacacac    900

tcctggcaga gggccgacct gggtgcctac ctcaacccgc gacctccagc ccctgaggcc    960

tggtcagagc cggtactgct ggccaagggc agctgtgcct actcagacct ccagagcatg   1020

ggcaccggcc ctgatgggtc ccccttgttt gggtgtctgt acgaagccaa tgattacgag   1080

gagattgtct ttctcatgtt caccctgaag caagccttcc cagctgagta cctgcctcag   1140

tga                                                                 1143


<210>  10
<211>  380
<212>  PRT
<213>  Homosapiens

<400>  10

Met Ala Ser Leu Pro Val Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Pro Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Ala Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu Asn Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Ile Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Gln Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Cys Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln 
    370                 375                 380 


<210>  11
<211>  4928
<212>  DNA
<213>  Homosapiens

<400>  11
aaacaggaag tcagtcagtt aagctggtgg cagcagccga ggccaccaag aggcaacggg     60

cggcaggttg cagtggaggg gcctccgctc ccctcggtgg tgtgtgggtc ctgggggtgc    120

ctgccggccc ggccgaggag gcccacgccc accatggtcc cctgctggaa ccatggcaac    180

atcacccgct ccaaggcgga ggagctgctt tccaggacag gcaaggacgg gagcttcctc    240

gtgcgtgcca gcgagtccat ctcccgggca tacgcgctct gcgtgctgta tcggaattgc    300

gtttacactt acagaattct gcccaatgaa gatgataaat tcactgttca ggcatccgaa    360

ggcgtctcca tgaggttctt caccaagctg gaccagctca tcgagtttta caagaaggaa    420

aacatggggc tggtgaccca tctgcaatac cctgtgccgc tggaggaaga ggacacaggc    480

gacgaccctg aggaggacac agtagaaagt gtcgtgtctc cacccgagct gcccccaaga    540

aacatcccgc tgactgccag ctcctgtgag gccaaggagg ttcctttttc aaacgagaat    600

ccccgagcga ccgagaccag ccggccgagc ctctccgaga cattgttcca gcgactgcaa    660

agcatggaca ccagtgggct tccagaagag catcttaagg ccatccaaga ttatttaagc    720

actcagctcg cccaggactc tgaatttgtg aagacagggt ccagcagtct tcctcacctg    780

aagaaactga ccacactgct ctgcaaggag ctctatggag aagtcatccg gaccctccca    840

tccctggagt ctctgcagag gttatttgac cagcagctct ccccgggcct ccgtccacgt    900

cctcaggttc ctggtgaggc caatcccatc aacatggtgt ccaagctcag ccaactgaca    960

agcctgttgt catccattga agacaaggtc aaggccttgc tgcacgaggg tcctgagtct   1020

ccgcaccggc cctcccttat ccctccagtc acctttgagg tgaaggcaga gtctctgggg   1080

attcctcaga aaatgcagct caaagtcgac gttgagtctg ggaaactgat cattaagaag   1140

tccaaggatg gttctgagga caagttctac agccacaaga aaatcctgca gctcattaag   1200

tcacagaaat ttctgaataa gttggtgatc ttggtggaaa cagagaagga gaagatcctg   1260

cggaaggaat atgtttttgc tgactccaaa aagagagaag gcttctgcca gctcctgcag   1320

cagatgaaga acaagcactc agagcagccg gagcccgaca tgatcaccat cttcatcggc   1380

acctggaaca tgggtaacgc cccccctccc aagaagatca cgtcctggtt tctctccaag   1440

gggcagggaa agacgcggga cgactctgcg gactacatcc cccatgacat ttacgtgatc   1500

ggcacccaag aggaccccct gagtgagaag gagtggctgg agatcctcaa acactccctg   1560

caagaaatca ccagtgtgac ttttaaaaca gtcgccatcc acacgctctg gaacatccgc   1620

atcgtggtgc tggccaagcc tgagcacgag aaccggatca gccacatctg tactgacaac   1680

gtgaagacag gcattgcaaa cacactgggg aacaagggag ccgtgggggt gtcgttcatg   1740

ttcaatggaa cctccttagg gttcgtcaac agccacttga cttcaggaag tgaaaagaaa   1800

ctcaggcgaa accaaaacta tatgaacatt ctccggttcc tggccctggg cgacaagaag   1860

ctgagtccct ttaacatcac tcaccgcttc acgcacctct tctggtttgg ggatcttaac   1920

taccgtgtgg atctgcctac ctgggaggca gaaaccatca tccagaaaat caagcagcag   1980

cagtacgcag acctcctgtc ccacgaccag ctgctcacag agaggaggga gcagaaggtc   2040

ttcctacact tcgaggagga agaaatcacg tttgccccaa cctaccgttt tgagagactg   2100

actcgggaca aatacgccta caccaagcag aaagcgacag ggatgaagta caacttgcct   2160

tcctggtgtg accgagtcct ctggaagtct tatcccctgg tgcacgtggt gtgtcagtct   2220

tatggcagta ccagcgacat catgacgagt gaccacagcc ctgtctttgc cacatttgag   2280

gcaggagtca cttcccagtt tgtctccaag aacggtcccg ggactgttga cagccaagga   2340

cagattgagt ttctcaggtg ctatgccaca ttgaagacca agtcccagac caaattctac   2400

ctggagttcc actcgagctg cttggagagt tttgtcaaga gtcaggaagg agaaaatgaa   2460

gaaggaagtg agggggagct ggtggtgaag tttggtgaga ctcttccaaa gctgaagccc   2520

attatctctg accctgagta cctgctagac cagcacatcc tcatcagcat caagtcctct   2580

gacagcgacg aatcctatgg cgagggctgc attgcccttc ggttagaggc cacagaaacg   2640

cagctgccca tctacacgcc tctcacccac catggggagt tgacaggcca cttccagggg   2700

gagatcaagc tgcagacctc tcagggcaag acgagggaga agctctatga ctttgtgaag   2760

acggagcgtg atgaatccag tgggccaaag accctgaaga gcctcaccag ccacgacccc   2820

atgaagcagt gggaagtcac tagcagggcc cctccgtgca gtggctccag catcactgaa   2880

atcatcaacc ccaactacat gggagtgggg ccctttgggc caccaatgcc cctgcacgtg   2940

aagcagacct tgtcccctga ccagcagccc acagcctgga gctacgacca gccgcccaag   3000

gactccccgc tggggccctg caggggagaa agtcctccga cacctcccgg ccagccgccc   3060

atatcaccca agaagttttt accctcaaca gcaaaccggg gtctccctcc caggacacag   3120

gagtcaaggc ccagtgacct ggggaagaac gcaggggaca cgctgcctca ggaggacctg   3180

ccgctgacga agcccgagat gtttgagaac cccctgtatg ggtccctgag ttccttccct   3240

aagcctgctc ccaggaagga ccaggaatcc cccaaaatgc cgcggaagga acccccgccc   3300

tgcccggaac ccggcatctt gtcgcccagc atcgtgctca ccaaagccca ggaggctgat   3360

cgcggcgagg ggcccggcaa gcaggtgccc gcgccccggc tgcgctcctt cacgtgctca   3420

tcctctgccg agggcagggc ggccggcggg gacaagagcc aagggaagcc caagaccccg   3480

gtcagctccc aggccccggt gccggccaag aggcccatca agccttccag atcggaaatc   3540

aaccagcaga ccccgcccac cccgacgccg cggccgccgc tgccagtcaa gagcccggcg   3600

gtgctgcacc tccagcactc caagggccgc gactaccgcg acaacaccga gctcccgcat   3660

cacggcaagc accggccgga ggaggggcca ccagggcctc taggcaggac tgccatgcag   3720

tgaagccctc agtgagctgc cactgagtcg ggagcccaga ggaacggcgt gaagccactg   3780

gaccctctcc cgggacctcc tgctggctcc tcctgcccag cttcctatgc aaggctttgt   3840

gttttcagga aagggcctag cttctgtgtg gcccacagag ttcactgcct gtgagactta   3900

gcaccaagtg ctgaggctgg aagaaaaacg cacaccagac gggcaacaaa cagtctgggt   3960

ccccagctcg ctcttggtac ttgggacccc agtgcctcgt tgagggcgcc attctgaaga   4020

aaggaactgc agcgccgatt tgagggtgga gatatagata ataataatat taataataat   4080

aatggccaca tggatcgaac actcatgatg tgccaagtgc tgtgctaagt gctttacgaa   4140

cattcgtcat atcaggatga cctcgagagc tgaggctcta gccacctaaa accacgtgcc   4200

caaacccacc agtttaaaac ggtgtgtgtt cggaggggtg aaagcattaa gaagcccagt   4260

gccctcctgg agtgagacaa gggctcggcc ttaaggagct gaagagtctg ggtagcttgt   4320

ttagggtaca agaagcctgt tctgtccagc ttcagtgaca caagctgctt tagctaaagt   4380

cccgcgggtt ccggcatggc taggctgaga gcagggatct acctggcttc tcagttcttt   4440

ggttggaagg agcaggaaat cagctcctat tctccagtgg agagatctgg cctcagcttg   4500

ggctagagat gccaaggcct gtgccaggtt ccctgtgccc tcctcgaggt gggcagccat   4560

caccagccac agttaagcca agccccccaa catgtattcc atcgtgctgg tagaagagtc   4620

tttgctgttg ctcccgaaag ccgtgctctc cagcctggct gccagggagg gtgggcctct   4680

tggttccagg ctcttgaaat agtgcagcct tttcttccta tctctgtggc tttcagctct   4740

gcttccttgg ttattaggag aatagatggg tgatgtcttt ccttatgttg ctttttcaac   4800

atagcagaat taatgtaggg agctaaatcc agtggtgtgt gtgaatgcag aagggaatgc   4860

accccacatt cccatgatgg aagtctgcgt aaccaataaa ttgtgccttt ctcactcaaa   4920

aaaaaaaa                                                            4928


<210>  12
<211>  1189
<212>  PRT
<213>  Homosapiens

<400>  12

Met Val Pro Cys Trp Asn His Gly Asn Ile Thr Arg Ser Lys Ala Glu 
1               5                   10                  15      


Glu Leu Leu Ser Arg Thr Gly Lys Asp Gly Ser Phe Leu Val Arg Ala 
            20                  25                  30          


Ser Glu Ser Ile Ser Arg Ala Tyr Ala Leu Cys Val Leu Tyr Arg Asn 
        35                  40                  45              


Cys Val Tyr Thr Tyr Arg Ile Leu Pro Asn Glu Asp Asp Lys Phe Thr 
    50                  55                  60                  


Val Gln Ala Ser Glu Gly Val Ser Met Arg Phe Phe Thr Lys Leu Asp 
65                  70                  75                  80  


Gln Leu Ile Glu Phe Tyr Lys Lys Glu Asn Met Gly Leu Val Thr His 
                85                  90                  95      


Leu Gln Tyr Pro Val Pro Leu Glu Glu Glu Asp Thr Gly Asp Asp Pro 
            100                 105                 110         


Glu Glu Asp Thr Val Glu Ser Val Val Ser Pro Pro Glu Leu Pro Pro 
        115                 120                 125             


Arg Asn Ile Pro Leu Thr Ala Ser Ser Cys Glu Ala Lys Glu Val Pro 
    130                 135                 140                 


Phe Ser Asn Glu Asn Pro Arg Ala Thr Glu Thr Ser Arg Pro Ser Leu 
145                 150                 155                 160 


Ser Glu Thr Leu Phe Gln Arg Leu Gln Ser Met Asp Thr Ser Gly Leu 
                165                 170                 175     


Pro Glu Glu His Leu Lys Ala Ile Gln Asp Tyr Leu Ser Thr Gln Leu 
            180                 185                 190         


Ala Gln Asp Ser Glu Phe Val Lys Thr Gly Ser Ser Ser Leu Pro His 
        195                 200                 205             


Leu Lys Lys Leu Thr Thr Leu Leu Cys Lys Glu Leu Tyr Gly Glu Val 
    210                 215                 220                 


Ile Arg Thr Leu Pro Ser Leu Glu Ser Leu Gln Arg Leu Phe Asp Gln 
225                 230                 235                 240 


Gln Leu Ser Pro Gly Leu Arg Pro Arg Pro Gln Val Pro Gly Glu Ala 
                245                 250                 255     


Asn Pro Ile Asn Met Val Ser Lys Leu Ser Gln Leu Thr Ser Leu Leu 
            260                 265                 270         


Ser Ser Ile Glu Asp Lys Val Lys Ala Leu Leu His Glu Gly Pro Glu 
        275                 280                 285             


Ser Pro His Arg Pro Ser Leu Ile Pro Pro Val Thr Phe Glu Val Lys 
    290                 295                 300                 


Ala Glu Ser Leu Gly Ile Pro Gln Lys Met Gln Leu Lys Val Asp Val 
305                 310                 315                 320 


Glu Ser Gly Lys Leu Ile Ile Lys Lys Ser Lys Asp Gly Ser Glu Asp 
                325                 330                 335     


Lys Phe Tyr Ser His Lys Lys Ile Leu Gln Leu Ile Lys Ser Gln Lys 
            340                 345                 350         


Phe Leu Asn Lys Leu Val Ile Leu Val Glu Thr Glu Lys Glu Lys Ile 
        355                 360                 365             


Leu Arg Lys Glu Tyr Val Phe Ala Asp Ser Lys Lys Arg Glu Gly Phe 
    370                 375                 380                 


Cys Gln Leu Leu Gln Gln Met Lys Asn Lys His Ser Glu Gln Pro Glu 
385                 390                 395                 400 


Pro Asp Met Ile Thr Ile Phe Ile Gly Thr Trp Asn Met Gly Asn Ala 
                405                 410                 415     


Pro Pro Pro Lys Lys Ile Thr Ser Trp Phe Leu Ser Lys Gly Gln Gly 
            420                 425                 430         


Lys Thr Arg Asp Asp Ser Ala Asp Tyr Ile Pro His Asp Ile Tyr Val 
        435                 440                 445             


Ile Gly Thr Gln Glu Asp Pro Leu Ser Glu Lys Glu Trp Leu Glu Ile 
    450                 455                 460                 


Leu Lys His Ser Leu Gln Glu Ile Thr Ser Val Thr Phe Lys Thr Val 
465                 470                 475                 480 


Ala Ile His Thr Leu Trp Asn Ile Arg Ile Val Val Leu Ala Lys Pro 
                485                 490                 495     


Glu His Glu Asn Arg Ile Ser His Ile Cys Thr Asp Asn Val Lys Thr 
            500                 505                 510         


Gly Ile Ala Asn Thr Leu Gly Asn Lys Gly Ala Val Gly Val Ser Phe 
        515                 520                 525             


Met Phe Asn Gly Thr Ser Leu Gly Phe Val Asn Ser His Leu Thr Ser 
    530                 535                 540                 


Gly Ser Glu Lys Lys Leu Arg Arg Asn Gln Asn Tyr Met Asn Ile Leu 
545                 550                 555                 560 


Arg Phe Leu Ala Leu Gly Asp Lys Lys Leu Ser Pro Phe Asn Ile Thr 
                565                 570                 575     


His Arg Phe Thr His Leu Phe Trp Phe Gly Asp Leu Asn Tyr Arg Val 
            580                 585                 590         


Asp Leu Pro Thr Trp Glu Ala Glu Thr Ile Ile Gln Lys Ile Lys Gln 
        595                 600                 605             


Gln Gln Tyr Ala Asp Leu Leu Ser His Asp Gln Leu Leu Thr Glu Arg 
    610                 615                 620                 


Arg Glu Gln Lys Val Phe Leu His Phe Glu Glu Glu Glu Ile Thr Phe 
625                 630                 635                 640 


Ala Pro Thr Tyr Arg Phe Glu Arg Leu Thr Arg Asp Lys Tyr Ala Tyr 
                645                 650                 655     


Thr Lys Gln Lys Ala Thr Gly Met Lys Tyr Asn Leu Pro Ser Trp Cys 
            660                 665                 670         


Asp Arg Val Leu Trp Lys Ser Tyr Pro Leu Val His Val Val Cys Gln 
        675                 680                 685             


Ser Tyr Gly Ser Thr Ser Asp Ile Met Thr Ser Asp His Ser Pro Val 
    690                 695                 700                 


Phe Ala Thr Phe Glu Ala Gly Val Thr Ser Gln Phe Val Ser Lys Asn 
705                 710                 715                 720 


Gly Pro Gly Thr Val Asp Ser Gln Gly Gln Ile Glu Phe Leu Arg Cys 
                725                 730                 735     


Tyr Ala Thr Leu Lys Thr Lys Ser Gln Thr Lys Phe Tyr Leu Glu Phe 
            740                 745                 750         


His Ser Ser Cys Leu Glu Ser Phe Val Lys Ser Gln Glu Gly Glu Asn 
        755                 760                 765             


Glu Glu Gly Ser Glu Gly Glu Leu Val Val Lys Phe Gly Glu Thr Leu 
    770                 775                 780                 


Pro Lys Leu Lys Pro Ile Ile Ser Asp Pro Glu Tyr Leu Leu Asp Gln 
785                 790                 795                 800 


His Ile Leu Ile Ser Ile Lys Ser Ser Asp Ser Asp Glu Ser Tyr Gly 
                805                 810                 815     


Glu Gly Cys Ile Ala Leu Arg Leu Glu Ala Thr Glu Thr Gln Leu Pro 
            820                 825                 830         


Ile Tyr Thr Pro Leu Thr His His Gly Glu Leu Thr Gly His Phe Gln 
        835                 840                 845             


Gly Glu Ile Lys Leu Gln Thr Ser Gln Gly Lys Thr Arg Glu Lys Leu 
    850                 855                 860                 


Tyr Asp Phe Val Lys Thr Glu Arg Asp Glu Ser Ser Gly Pro Lys Thr 
865                 870                 875                 880 


Leu Lys Ser Leu Thr Ser His Asp Pro Met Lys Gln Trp Glu Val Thr 
                885                 890                 895     


Ser Arg Ala Pro Pro Cys Ser Gly Ser Ser Ile Thr Glu Ile Ile Asn 
            900                 905                 910         


Pro Asn Tyr Met Gly Val Gly Pro Phe Gly Pro Pro Met Pro Leu His 
        915                 920                 925             


Val Lys Gln Thr Leu Ser Pro Asp Gln Gln Pro Thr Ala Trp Ser Tyr 
    930                 935                 940                 


Asp Gln Pro Pro Lys Asp Ser Pro Leu Gly Pro Cys Arg Gly Glu Ser 
945                 950                 955                 960 


Pro Pro Thr Pro Pro Gly Gln Pro Pro Ile Ser Pro Lys Lys Phe Leu 
                965                 970                 975     


Pro Ser Thr Ala Asn Arg Gly Leu Pro Pro Arg Thr Gln Glu Ser Arg 
            980                 985                 990         


Pro Ser Asp Leu Gly Lys Asn Ala  Gly Asp Thr Leu Pro  Gln Glu Asp 
        995                 1000                 1005             


Leu Pro  Leu Thr Lys Pro Glu  Met Phe Glu Asn Pro  Leu Tyr Gly 
    1010                 1015                 1020             


Ser Leu  Ser Ser Phe Pro Lys  Pro Ala Pro Arg Lys  Asp Gln Glu 
    1025                 1030                 1035             


Ser Pro  Lys Met Pro Arg Lys  Glu Pro Pro Pro Cys  Pro Glu Pro 
    1040                 1045                 1050             


Gly Ile  Leu Ser Pro Ser Ile  Val Leu Thr Lys Ala  Gln Glu Ala 
    1055                 1060                 1065             


Asp Arg  Gly Glu Gly Pro Gly  Lys Gln Val Pro Ala  Pro Arg Leu 
    1070                 1075                 1080             


Arg Ser  Phe Thr Cys Ser Ser  Ser Ala Glu Gly Arg  Ala Ala Gly 
    1085                 1090                 1095             


Gly Asp  Lys Ser Gln Gly Lys  Pro Lys Thr Pro Val  Ser Ser Gln 
    1100                 1105                 1110             


Ala Pro  Val Pro Ala Lys Arg  Pro Ile Lys Pro Ser  Arg Ser Glu 
    1115                 1120                 1125             


Ile Asn  Gln Gln Thr Pro Pro  Thr Pro Thr Pro Arg  Pro Pro Leu 
    1130                 1135                 1140             


Pro Val  Lys Ser Pro Ala Val  Leu His Leu Gln His  Ser Lys Gly 
    1145                 1150                 1155             


Arg Asp  Tyr Arg Asp Asn Thr  Glu Leu Pro His His  Gly Lys His 
    1160                 1165                 1170             


Arg Pro  Glu Glu Gly Pro Pro  Gly Pro Leu Gly Arg  Thr Ala Met 
    1175                 1180                 1185             


Gln 
    


<210>  13
<211>  3276
<212>  DNA
<213>  Homosapiens

<400>  13
atttccggca tgagccggaa gaccgtcccg gatggcctcg gggactgcca gtgtgtggag     60

gtgagctccg ggattgccgg cattcccgct tctgctggtt gcttcatgct gcaggctgcg    120

gccgtcagcc ctcgctcgca ttggtggcgc tgaggtgccg gggcagcaag tgacatgtcg    180

tcgggcctcc gcgccgctga cttcccccgc tggaagcgcc acatctcgga gcaactgagg    240

cgccgggacc ggctgcagag acaggcgttc gaggagatca tcctgcaata acaaattgct    300

ggaaaagtca gatcttcatt cagtgttggc ccagaaacta caggctgaaa agcatgacgt    360

accaaacagg cacgagataa gtcccggaca tgatggcaca tggaatgaca atcagctaca    420

agaaatggcc caactgagga ttaagcacca agaggaactg actgaattac acaagaaacg    480

tggggagtta gctcaactgg tgattgacct gaataaccaa atgcagcgga aggacaggga    540

gatgcagatg aatgaagcaa aaattgcaga atgtttgcag actatctctg acctggagac    600

ggagtgccta gacctgcgca ctaagctttg tgaccttgaa agagccaacc agaccctgaa    660

ggatgaatat gatgccctgc agatcacttt tactgccttg gagggaaaac tgaggaaaac    720

tacggaagag aaccaggagc tggtcaccag atggatggct gagaaagccc aggaagccaa    780

tcggcttaat gcagagaatg aaaaagactc caggaggcgg caagcccggc tgcagaaaga    840

gcttgcagaa gcagcaaagg aacctctacc agtcgaacag gatgatgaca ttgaggtcat    900

tgtggatgaa acttctgatc acacagaaga gacctctcct gtgcgagcca tcagcagagc    960

agccacgaga cgctctgtct cttccttccc agtcccccag gacaatgtgg atactcatcc   1020

tggttctggt aaagaagtga gggtaccagc tactgccttg tgtgtcttcg atgcacatga   1080

tggggaagtc aacgctgtgc agttcagtcc aggttcccgg ttactggcca ctggaggcat   1140

ggaccgcagg gttaagcttt gggaagtatt tggagaaaaa tgtgagttca agggttccct   1200

atctggcagt aatgcaggaa ttacaagcat tgaatttgat agtgctggat cttacctctt   1260

agcagcttca aatgattttg caagccgaat ctggactgtg gatgattatc gattacggca   1320

cacactcacg ggacacagtg ggaaagtgct gtctgctaag ttcctgctgg acaatgcgcg   1380

gattgtctca ggaagtcacg accggactct caaactctgg gatctacgca gcaaagtctg   1440

cataaagaca gtgtttgcag gatccagttg caatgatatt gtctgcacag agcaatgtgt   1500

aatgagtgga cattttgaca agaaaattcg tttctgggac attcgatcag agagcatagt   1560

tcgagagatg gagctgttgg gaaagattac tgccctggac ttaaacccag aaaggactga   1620

gctcctgagc tgctcccgtg atgacttgct aaaagttatt gatctccgaa caaatgctat   1680

caagcagaca ttcagtgcac ctgggttcaa gtgcggctct gactggacca gagttgtctt   1740

cagccctgat ggcagttacg tggcggcagg ctctgctgag ggctctctgt atatctggag   1800

tgtgctcaca gggaaagtgg aaaaggttct ttcaaagcag cacagctcat ccatcaatgc   1860

ggtggcgtgg tcgccctctg gctcgcacgt tgtcagtgtg gacaaaggat gcaaagctgt   1920

gctgtgggca cagtactgac ggggctctca gggctgggag gaccccagtg ccctcctcag   1980

aagaagcaca tgggctcctg cagccctgtc ctggcaggtg atgtgctggg tatagcatgg   2040

acctcccaga gaagctcaag ctatgtggca ctgtagcttt gccgtgaatg ggatttctga   2100

agatttgact gaggtctctc ttggcctgga agaataacac tgaaaaaacc tgacgctgcg   2160

gtcacttagc agaggctcag gttcttgcct tgggaaacac tactagctct gaccttccat   2220

acctcacttg ggggagcaca gggccccgct gggcctcctc accaacggca gtgccaaaat   2280

cagcccccac atcaaggtgg tgttctctgt gctttctctc gtccttccaa agtcggttct   2340

ggcctaacgc atgtcccaac accttgggtt catttgcccg gtgaactcac tttaagcatt   2400

ggattaacgg aaactcccga actacagacc cctccctggt gggttgcatg aatgtgtctc   2460

attactgctg aaatgtcctc acatctcttt cactgttctt cagagctttc tggctctctt   2520

tcccccacaa aattcgacat atttaaaaat ctccgtgtgg ctttaaaaaa tggttttttg   2580

tttttttgtt tttttgaggt gggagaggat gtgtgaaaat cttttccagg gaaatgggtt   2640

cgctgcagag gtaaggatgt gttcctgtat cgatctgcag acacccagaa ggtgggtgca   2700

cactgcatgc ttgggggtgc caagggattc gagacctcca acatacttgt ctgaaggtgg   2760

tgattctggc catggcccct ctgccaagcc tgtgtgcgat gcccttggtg ctttagtgca   2820

agaagcctag gctcagaagc acagcagcgc catctttccg tttcaggggt tgtgatgaag   2880

gccaaggaaa aacatttatc tttactattt tacctacgta taaagtttta gttcattggg   2940

tgtgcgaaac acccttttta tcacttttaa atttgcactt tatttttttt cttccatgct   3000

tgttctctgg acatttgggg atgtgagtgt tagagctggt gagagaggag tcaggtggcc   3060

ttcccaccga tggtcctggc ctccacctgc cctctcttcc ctgcctgatc accgctttcc   3120

aatttgccct tcagagaact taagtcaagg agagttgaaa ttcacaggcc agggcacatc   3180

ttttatttat ttcattatgt tggccaacag aacttgattg taaataataa taaagaaatc   3240

tgttatatac ttttcaaaaa aaaaaaaaaa aaaaaa                             3276


<210>  14
<211>  504
<212>  PRT
<213>  Homosapiens

<400>  14

Met Ala Gln Leu Arg Ile Lys His Gln Glu Glu Leu Thr Glu Leu His 
1               5                   10                  15      


Lys Lys Arg Gly Glu Leu Ala Gln Leu Val Ile Asp Leu Asn Asn Gln 
            20                  25                  30          


Met Gln Arg Lys Asp Arg Glu Met Gln Met Asn Glu Ala Lys Ile Ala 
        35                  40                  45              


Glu Cys Leu Gln Thr Ile Ser Asp Leu Glu Thr Glu Cys Leu Asp Leu 
    50                  55                  60                  


Arg Thr Lys Leu Cys Asp Leu Glu Arg Ala Asn Gln Thr Leu Lys Asp 
65                  70                  75                  80  


Glu Tyr Asp Ala Leu Gln Ile Thr Phe Thr Ala Leu Glu Gly Lys Leu 
                85                  90                  95      


Arg Lys Thr Thr Glu Glu Asn Gln Glu Leu Val Thr Arg Trp Met Ala 
            100                 105                 110         


Glu Lys Ala Gln Glu Ala Asn Arg Leu Asn Ala Glu Asn Glu Lys Asp 
        115                 120                 125             


Ser Arg Arg Arg Gln Ala Arg Leu Gln Lys Glu Leu Ala Glu Ala Ala 
    130                 135                 140                 


Lys Glu Pro Leu Pro Val Glu Gln Asp Asp Asp Ile Glu Val Ile Val 
145                 150                 155                 160 


Asp Glu Thr Ser Asp His Thr Glu Glu Thr Ser Pro Val Arg Ala Ile 
                165                 170                 175     


Ser Arg Ala Ala Thr Arg Arg Ser Val Ser Ser Phe Pro Val Pro Gln 
            180                 185                 190         


Asp Asn Val Asp Thr His Pro Gly Ser Gly Lys Glu Val Arg Val Pro 
        195                 200                 205             


Ala Thr Ala Leu Cys Val Phe Asp Ala His Asp Gly Glu Val Asn Ala 
    210                 215                 220                 


Val Gln Phe Ser Pro Gly Ser Arg Leu Leu Ala Thr Gly Gly Met Asp 
225                 230                 235                 240 


Arg Arg Val Lys Leu Trp Glu Val Phe Gly Glu Lys Cys Glu Phe Lys 
                245                 250                 255     


Gly Ser Leu Ser Gly Ser Asn Ala Gly Ile Thr Ser Ile Glu Phe Asp 
            260                 265                 270         


Ser Ala Gly Ser Tyr Leu Leu Ala Ala Ser Asn Asp Phe Ala Ser Arg 
        275                 280                 285             


Ile Trp Thr Val Asp Asp Tyr Arg Leu Arg His Thr Leu Thr Gly His 
    290                 295                 300                 


Ser Gly Lys Val Leu Ser Ala Lys Phe Leu Leu Asp Asn Ala Arg Ile 
305                 310                 315                 320 


Val Ser Gly Ser His Asp Arg Thr Leu Lys Leu Trp Asp Leu Arg Ser 
                325                 330                 335     


Lys Val Cys Ile Lys Thr Val Phe Ala Gly Ser Ser Cys Asn Asp Ile 
            340                 345                 350         


Val Cys Thr Glu Gln Cys Val Met Ser Gly His Phe Asp Lys Lys Ile 
        355                 360                 365             


Arg Phe Trp Asp Ile Arg Ser Glu Ser Ile Val Arg Glu Met Glu Leu 
    370                 375                 380                 


Leu Gly Lys Ile Thr Ala Leu Asp Leu Asn Pro Glu Arg Thr Glu Leu 
385                 390                 395                 400 


Leu Ser Cys Ser Arg Asp Asp Leu Leu Lys Val Ile Asp Leu Arg Thr 
                405                 410                 415     


Asn Ala Ile Lys Gln Thr Phe Ser Ala Pro Gly Phe Lys Cys Gly Ser 
            420                 425                 430         


Asp Trp Thr Arg Val Val Phe Ser Pro Asp Gly Ser Tyr Val Ala Ala 
        435                 440                 445             


Gly Ser Ala Glu Gly Ser Leu Tyr Ile Trp Ser Val Leu Thr Gly Lys 
    450                 455                 460                 


Val Glu Lys Val Leu Ser Lys Gln His Ser Ser Ser Ile Asn Ala Val 
465                 470                 475                 480 


Ala Trp Ser Pro Ser Gly Ser His Val Val Ser Val Asp Lys Gly Cys 
                485                 490                 495     


Lys Ala Val Leu Trp Ala Gln Tyr 
            500                 


<210>  15
<211>  3333
<212>  DNA
<213>  Homosapiens

<400>  15
atttccggca tgagccggaa gaccgtcccg gatggcctcg gggactgcca gtgtgtggag     60

gtgagctccg ggattgccgg cattcccgct tctgctggtt gcttcatgct gcaggctgcg    120

gccgtcagcc ctcgctcgca ttggtggcgc tgaggtgccg gggcagcaag tgacatgtcg    180

tcgggcctcc gcgccgctga cttcccccgc tggaagcgcc acatctcgga gcaactgagg    240

cgccgggacc ggctgcagag acaggcgttc gaggagatca tcctgcaata acaaattgct    300

ggaaaagtca gatcttcatt cagtgttggc ccagaaacta caggctgaaa agcatgacgt    360

accaaacagg cacgagataa gtcccggaca tgatggcaca tggaatgaca atcagctaca    420

agaaatggcc caactgagga ttaagcacca agaggaactg actgaattac acaagaaacg    480

tggggagtta gctcaactgg tgattgacct gaataaccaa atgcagcgga aggacaggga    540

gatgcagatg aatgaagcaa aaattgcaga atgtttgcag actatctctg acctggagac    600

ggagtgccta gacctgcgca ctaagctttg tgaccttgaa agagccaacc agaccctgaa    660

ggatgaatat gatgccctgc agatcacttt tactgccttg gagggaaaac tgaggaaaac    720

tacggaagag aaccaggagc tggtcaccag atggatggct gagaaagccc aggaagccaa    780

tcggcttaat gcagagaatg aaaaagactc caggaggcgg caagcccggc tgcagaaaga    840

gcttgcagaa gcagcaaagg aacctctacc agtcgaacag gatgatgaca ttgaggtcat    900

tgtggatgaa acttctgatc acacagaaga gacctctcct gtgcgagcca tcagcagagc    960

agccactaag cgactctcgc agcctgctgg aggccttctg gattctatca ctaatatctt   1020

tgggagacgc tctgtctctt ccttcccagt cccccaggac aatgtggata ctcatcctgg   1080

ttctggtaaa gaagtgaggg taccagctac tgccttgtgt gtcttcgatg cacatgatgg   1140

ggaagtcaac gctgtgcagt tcagtccagg ttcccggtta ctggccactg gaggcatgga   1200

ccgcagggtt aagctttggg aagtatttgg agaaaaatgt gagttcaagg gttccctatc   1260

tggcagtaat gcaggaatta caagcattga atttgatagt gctggatctt acctcttagc   1320

agcttcaaat gattttgcaa gccgaatctg gactgtggat gattatcgat tacggcacac   1380

actcacggga cacagtggga aagtgctgtc tgctaagttc ctgctggaca atgcgcggat   1440

tgtctcagga agtcacgacc ggactctcaa actctgggat ctacgcagca aagtctgcat   1500

aaagacagtg tttgcaggat ccagttgcaa tgatattgtc tgcacagagc aatgtgtaat   1560

gagtggacat tttgacaaga aaattcgttt ctgggacatt cgatcagaga gcatagttcg   1620

agagatggag ctgttgggaa agattactgc cctggactta aacccagaaa ggactgagct   1680

cctgagctgc tcccgtgatg acttgctaaa agttattgat ctccgaacaa atgctatcaa   1740

gcagacattc agtgcacctg ggttcaagtg cggctctgac tggaccagag ttgtcttcag   1800

ccctgatggc agttacgtgg cggcaggctc tgctgagggc tctctgtata tctggagtgt   1860

gctcacaggg aaagtggaaa aggttctttc aaagcagcac agctcatcca tcaatgcggt   1920

ggcgtggtcg ccctctggct cgcacgttgt cagtgtggac aaaggatgca aagctgtgct   1980

gtgggcacag tactgacggg gctctcaggg ctgggaggac cccagtgccc tcctcagaag   2040

aagcacatgg gctcctgcag ccctgtcctg gcaggtgatg tgctgggtat agcatggacc   2100

tcccagagaa gctcaagcta tgtggcactg tagctttgcc gtgaatggga tttctgaaga   2160

tttgactgag gtctctcttg gcctggaaga ataacactga aaaaacctga cgctgcggtc   2220

acttagcaga ggctcaggtt cttgccttgg gaaacactac tagctctgac cttccatacc   2280

tcacttgggg gagcacaggg ccccgctggg cctcctcacc aacggcagtg ccaaaatcag   2340

cccccacatc aaggtggtgt tctctgtgct ttctctcgtc cttccaaagt cggttctggc   2400

ctaacgcatg tcccaacacc ttgggttcat ttgcccggtg aactcacttt aagcattgga   2460

ttaacggaaa ctcccgaact acagacccct ccctggtggg ttgcatgaat gtgtctcatt   2520

actgctgaaa tgtcctcaca tctctttcac tgttcttcag agctttctgg ctctctttcc   2580

cccacaaaat tcgacatatt taaaaatctc cgtgtggctt taaaaaatgg ttttttgttt   2640

ttttgttttt ttgaggtggg agaggatgtg tgaaaatctt ttccagggaa atgggttcgc   2700

tgcagaggta aggatgtgtt cctgtatcga tctgcagaca cccagaaggt gggtgcacac   2760

tgcatgcttg ggggtgccaa gggattcgag acctccaaca tacttgtctg aaggtggtga   2820

ttctggccat ggcccctctg ccaagcctgt gtgcgatgcc cttggtgctt tagtgcaaga   2880

agcctaggct cagaagcaca gcagcgccat ctttccgttt caggggttgt gatgaaggcc   2940

aaggaaaaac atttatcttt actattttac ctacgtataa agttttagtt cattgggtgt   3000

gcgaaacacc ctttttatca cttttaaatt tgcactttat tttttttctt ccatgcttgt   3060

tctctggaca tttggggatg tgagtgttag agctggtgag agaggagtca ggtggccttc   3120

ccaccgatgg tcctggcctc cacctgccct ctcttccctg cctgatcacc gctttccaat   3180

ttgcccttca gagaacttaa gtcaaggaga gttgaaattc acaggccagg gcacatcttt   3240

tatttatttc attatgttgg ccaacagaac ttgattgtaa ataataataa agaaatctgt   3300

tatatacttt tcaaaaaaaa aaaaaaaaaa aaa                                3333


<210>  16
<211>  523
<212>  PRT
<213>  Homosapiens

<400>  16

Met Ala Gln Leu Arg Ile Lys His Gln Glu Glu Leu Thr Glu Leu His 
1               5                   10                  15      


Lys Lys Arg Gly Glu Leu Ala Gln Leu Val Ile Asp Leu Asn Asn Gln 
            20                  25                  30          


Met Gln Arg Lys Asp Arg Glu Met Gln Met Asn Glu Ala Lys Ile Ala 
        35                  40                  45              


Glu Cys Leu Gln Thr Ile Ser Asp Leu Glu Thr Glu Cys Leu Asp Leu 
    50                  55                  60                  


Arg Thr Lys Leu Cys Asp Leu Glu Arg Ala Asn Gln Thr Leu Lys Asp 
65                  70                  75                  80  


Glu Tyr Asp Ala Leu Gln Ile Thr Phe Thr Ala Leu Glu Gly Lys Leu 
                85                  90                  95      


Arg Lys Thr Thr Glu Glu Asn Gln Glu Leu Val Thr Arg Trp Met Ala 
            100                 105                 110         


Glu Lys Ala Gln Glu Ala Asn Arg Leu Asn Ala Glu Asn Glu Lys Asp 
        115                 120                 125             


Ser Arg Arg Arg Gln Ala Arg Leu Gln Lys Glu Leu Ala Glu Ala Ala 
    130                 135                 140                 


Lys Glu Pro Leu Pro Val Glu Gln Asp Asp Asp Ile Glu Val Ile Val 
145                 150                 155                 160 


Asp Glu Thr Ser Asp His Thr Glu Glu Thr Ser Pro Val Arg Ala Ile 
                165                 170                 175     


Ser Arg Ala Ala Thr Lys Arg Leu Ser Gln Pro Ala Gly Gly Leu Leu 
            180                 185                 190         


Asp Ser Ile Thr Asn Ile Phe Gly Arg Arg Ser Val Ser Ser Phe Pro 
        195                 200                 205             


Val Pro Gln Asp Asn Val Asp Thr His Pro Gly Ser Gly Lys Glu Val 
    210                 215                 220                 


Arg Val Pro Ala Thr Ala Leu Cys Val Phe Asp Ala His Asp Gly Glu 
225                 230                 235                 240 


Val Asn Ala Val Gln Phe Ser Pro Gly Ser Arg Leu Leu Ala Thr Gly 
                245                 250                 255     


Gly Met Asp Arg Arg Val Lys Leu Trp Glu Val Phe Gly Glu Lys Cys 
            260                 265                 270         


Glu Phe Lys Gly Ser Leu Ser Gly Ser Asn Ala Gly Ile Thr Ser Ile 
        275                 280                 285             


Glu Phe Asp Ser Ala Gly Ser Tyr Leu Leu Ala Ala Ser Asn Asp Phe 
    290                 295                 300                 


Ala Ser Arg Ile Trp Thr Val Asp Asp Tyr Arg Leu Arg His Thr Leu 
305                 310                 315                 320 


Thr Gly His Ser Gly Lys Val Leu Ser Ala Lys Phe Leu Leu Asp Asn 
                325                 330                 335     


Ala Arg Ile Val Ser Gly Ser His Asp Arg Thr Leu Lys Leu Trp Asp 
            340                 345                 350         


Leu Arg Ser Lys Val Cys Ile Lys Thr Val Phe Ala Gly Ser Ser Cys 
        355                 360                 365             


Asn Asp Ile Val Cys Thr Glu Gln Cys Val Met Ser Gly His Phe Asp 
    370                 375                 380                 


Lys Lys Ile Arg Phe Trp Asp Ile Arg Ser Glu Ser Ile Val Arg Glu 
385                 390                 395                 400 


Met Glu Leu Leu Gly Lys Ile Thr Ala Leu Asp Leu Asn Pro Glu Arg 
                405                 410                 415     


Thr Glu Leu Leu Ser Cys Ser Arg Asp Asp Leu Leu Lys Val Ile Asp 
            420                 425                 430         


Leu Arg Thr Asn Ala Ile Lys Gln Thr Phe Ser Ala Pro Gly Phe Lys 
        435                 440                 445             


Cys Gly Ser Asp Trp Thr Arg Val Val Phe Ser Pro Asp Gly Ser Tyr 
    450                 455                 460                 


Val Ala Ala Gly Ser Ala Glu Gly Ser Leu Tyr Ile Trp Ser Val Leu 
465                 470                 475                 480 


Thr Gly Lys Val Glu Lys Val Leu Ser Lys Gln His Ser Ser Ser Ile 
                485                 490                 495     


Asn Ala Val Ala Trp Ser Pro Ser Gly Ser His Val Val Ser Val Asp 
            500                 505                 510         


Lys Gly Cys Lys Ala Val Leu Trp Ala Gln Tyr 
        515                 520             


<210>  17
<211>  2897
<212>  DNA
<213>  Homosapiens

<400>  17
atttccggca tgagccggaa gaccgtcccg gatggcctcg gggactgcca gtgtgtggag     60

gtgagctccg ggattgccgg cattcccgct tctgctggtt gcttcatgct gcaggctgcg    120

gccgtcagcc ctcgctcgca ttggtggcgc tgaggtgccg gggcagcaag tgacatgtcg    180

tcgggcctcc gcgccgctga cttcccccgc tggaagcgcc acatctcgga gcaactgagg    240

cgccgggacc ggctgcagag acaggcgttc gaggagatca tcctgcaata acaaattgct    300

ggaaaagtca gatcttcatt cagtgttggc ccagaaacta caggctgaaa agcatgacgt    360

accaaacagg cacgagataa ggaggcggca agcccggctg cagaaagagc ttgcagaagc    420

agcaaaggaa cctctaccag tcgaacagga tgatgacatt gaggtcattg tggatgaaac    480

ttctgatcac acagaagaga cctctcctgt gcgagccatc agcagagcag ccaccgactc    540

tcgcagcctg ctggaggcct tctggattct atcactaata tctttgggag acgctctgtc    600

tcttccttcc cagtccccca ggacaatgtg gatactcatc ctggttctgg taaagaagtg    660

agggtaccag ctactgcctt gtgtgtcttc gatgcacatg atggggaagt caacgctgtg    720

cagttcagtc caggttcccg gttactggcc actggaggca tggaccgcag ggttaagctt    780

tgggaagtat ttggagaaaa atgtgagttc aagggttccc tatctggcag taatgcagga    840

attacaagca ttgaatttga tagtgctgga tcttacctct tagcagcttc aaatgatttt    900

gcaagccgaa tctggactgt ggatgattat cgattacggc acacactcac gggacacagt    960

gggaaagtgc tgtctgctaa gttcctgctg gacaatgcgc ggattgtctc aggaagtcac   1020

gaccggactc tcaaactctg ggatctacgc agcaaagtct gcataaagac agtgtttgca   1080

ggatccagtt gcaatgatat tgtctgcaca gagcaatgtg taatgagtgg acattttgac   1140

aagaaaattc gtttctggga cattcgatca gagagcatag ttcgagagat ggagctgttg   1200

ggaaagatta ctgccctgga cttaaaccca gaaaggactg agctcctgag ctgctcccgt   1260

gatgacttgc taaaagttat tgatctccga acaaatgcta tcaagcagac attcagtgca   1320

cctgggttca agtgcggctc tgactggacc agagttgtct tcagccctga tggcagttac   1380

gtggcggcag gctctgctga gggctctctg tatatctgga gtgtgctcac agggaaagtg   1440

gaaaaggttc tttcaaagca gcacagctca tccatcaatg cggtggcgtg gtcgccctct   1500

ggctcgcacg ttgtcagtgt ggacaaagga tgcaaagctg tgctgtgggc acagtactga   1560

cggggctctc agggctggga ggaccccagt gccctcctca gaagaagcac atgggctcct   1620

gcagccctgt cctggcaggt gatgtgctgg gtatagcatg gacctcccag agaagctcaa   1680

gctatgtggc actgtagctt tgccgtgaat gggatttctg aagatttgac tgaggtctct   1740

cttggcctgg aagaataaca ctgaaaaaac ctgacgctgc ggtcacttag cagaggctca   1800

ggttcttgcc ttgggaaaca ctactagctc tgaccttcca tacctcactt gggggagcac   1860

agggccccgc tgggcctcct caccaacggc agtgccaaaa tcagccccca catcaaggtg   1920

gtgttctctg tgctttctct cgtccttcca aagtcggttc tggcctaacg catgtcccaa   1980

caccttgggt tcatttgccc ggtgaactca ctttaagcat tggattaacg gaaactcccg   2040

aactacagac ccctccctgg tgggttgcat gaatgtgtct cattactgct gaaatgtcct   2100

cacatctctt tcactgttct tcagagcttt ctggctctct ttcccccaca aaattcgaca   2160

tatttaaaaa tctccgtgtg gctttaaaaa atggtttttt gtttttttgt ttttttgagg   2220

tgggagagga tgtgtgaaaa tcttttccag ggaaatgggt tcgctgcaga ggtaaggatg   2280

tgttcctgta tcgatctgca gacacccaga aggtgggtgc acactgcatg cttgggggtg   2340

ccaagggatt cgagacctcc aacatacttg tctgaaggtg gtgattctgg ccatggcccc   2400

tctgccaagc ctgtgtgcga tgcccttggt gctttagtgc aagaagccta ggctcagaag   2460

cacagcagcg ccatctttcc gtttcagggg ttgtgatgaa ggccaaggaa aaacatttat   2520

ctttactatt ttacctacgt ataaagtttt agttcattgg gtgtgcgaaa cacccttttt   2580

atcactttta aatttgcact ttattttttt tcttccatgc ttgttctctg gacatttggg   2640

gatgtgagtg ttagagctgg tgagagagga gtcaggtggc cttcccaccg atggtcctgg   2700

cctccacctg ccctctcttc cctgcctgat caccgctttc caatttgccc ttcagagaac   2760

ttaagtcaag gagagttgaa attcacaggc cagggcacat cttttattta tttcattatg   2820

ttggccaaca gaacttgatt gtaaataata ataaagaaat ctgttatata cttttcaaaa   2880

aaaaaaaaaa aaaaaaa                                                  2897


<210>  18
<211>  266
<212>  PRT
<213>  Homosapiens

<400>  18

Met Asp Arg Arg Val Lys Leu Trp Glu Val Phe Gly Glu Lys Cys Glu 
1               5                   10                  15      


Phe Lys Gly Ser Leu Ser Gly Ser Asn Ala Gly Ile Thr Ser Ile Glu 
            20                  25                  30          


Phe Asp Ser Ala Gly Ser Tyr Leu Leu Ala Ala Ser Asn Asp Phe Ala 
        35                  40                  45              


Ser Arg Ile Trp Thr Val Asp Asp Tyr Arg Leu Arg His Thr Leu Thr 
    50                  55                  60                  


Gly His Ser Gly Lys Val Leu Ser Ala Lys Phe Leu Leu Asp Asn Ala 
65                  70                  75                  80  


Arg Ile Val Ser Gly Ser His Asp Arg Thr Leu Lys Leu Trp Asp Leu 
                85                  90                  95      


Arg Ser Lys Val Cys Ile Lys Thr Val Phe Ala Gly Ser Ser Cys Asn 
            100                 105                 110         


Asp Ile Val Cys Thr Glu Gln Cys Val Met Ser Gly His Phe Asp Lys 
        115                 120                 125             


Lys Ile Arg Phe Trp Asp Ile Arg Ser Glu Ser Ile Val Arg Glu Met 
    130                 135                 140                 


Glu Leu Leu Gly Lys Ile Thr Ala Leu Asp Leu Asn Pro Glu Arg Thr 
145                 150                 155                 160 


Glu Leu Leu Ser Cys Ser Arg Asp Asp Leu Leu Lys Val Ile Asp Leu 
                165                 170                 175     


Arg Thr Asn Ala Ile Lys Gln Thr Phe Ser Ala Pro Gly Phe Lys Cys 
            180                 185                 190         


Gly Ser Asp Trp Thr Arg Val Val Phe Ser Pro Asp Gly Ser Tyr Val 
        195                 200                 205             


Ala Ala Gly Ser Ala Glu Gly Ser Leu Tyr Ile Trp Ser Val Leu Thr 
    210                 215                 220                 


Gly Lys Val Glu Lys Val Leu Ser Lys Gln His Ser Ser Ser Ile Asn 
225                 230                 235                 240 


Ala Val Ala Trp Ser Pro Ser Gly Ser His Val Val Ser Val Asp Lys 
                245                 250                 255     


Gly Cys Lys Ala Val Leu Trp Ala Gln Tyr 
            260                 265     


<210>  19
<211>  1564
<212>  DNA
<213>  Homosapiens

<400>  19
cccctacaaa ttccccacat cacgtaggcc aggagcctca gcgctgcccc ttcaggctca     60

tctggcaaga cggtaccagc ttgctcagaa caggggctgg ctattcatca tctcagagca    120

tagagaccct ctccttgcca cccggccctt cccacctggt tggtgacaat cacaaggtgt    180

agaagttgcc agggacagat aacatggcag ccagcgggaa gaccagcaag tccgaaccga    240

accatgttat cttcaagaag atctcccggg acaaatcggt gaccatctac ctggggaaca    300

gagactacat agaccatgtc agccaagtcc agcctgtgga tggtgtcgtg ttggttgatc    360

ctgatcttgt gaagggaaag aaagtgtatg tcactctgac ctgcgccttc cgctatggcc    420

aagaggacat tgacgtgatc ggcttgacct tccgcaggga cctgtacttc tcccgggtcc    480

aggtgtatcc tcctgtgggg gccgcgagca cccccacaaa actgcaagag agcctgctta    540

aaaagctggg gagcaacacg tacccctttc tcctgacgtt tcctgactac ttgccctgtt    600

cagtgatgtt gcagccagct ccacaagatt cagggaagtc ctgtggggtt gactttgagg    660

tcaaagcatt cgccacagac agcaccgatg ccgaagagga caaaatcccc aagaagagct    720

ccgtgcgatt actgatccgc aaagtacagc atgccccact tgagatgggt ccccagcccc    780

gagctgaggc ggcctggcag ttcttcatgt ctgacaagcc cctgcacctt gcggtctctc    840

tcaacaaaga gatctatttc catggggagc ccatccctgt gaccgtgact gtcaccaata    900

acacagagaa gaccgtgaag aagattaaag cattcgtgga acaggtggcc aatgtggttc    960

tctactcgag tgattattac gtcaagcccg tggctatgga ggaagcgcaa gaaaaagtgc   1020

caccaaacag cactttgacc aagacgctga cgctgctgcc cttgctggct aacaatcgag   1080

aaaggagagg cattgccctg gatgggaaaa tcaagcacga ggacacaaac cttgcctcca   1140

gcaccatcat taaggagggc atagaccgga ccgtcctggg aatcctggtg tcttaccaga   1200

tcaaggtgaa gctcacagtg tcaggctttc tgggagagct cacctccagt gaagtcgcca   1260

ctgaggtccc attccgcctc atgcaccctc agcctgagga cccagctaag gaaagttatc   1320

aggatgcaaa tttagttttt gaggagtttg ctcgccataa tctgaaagat gcaggagaag   1380

ctgaggaggg gaagagagac aagaatgacg ctgatgagtg aagatgtcgg ctcaggatgc   1440

cggaaaatga cctgtagtta ccagtgcaac gagcaaagcc ccacagttta gtcctttgga   1500

gttatgctgc gtatgaaagg atgagtcttc ttccgagaaa taaagcttgt ttgttctccc   1560

ctgg                                                                1564


<210>  20
<211>  405
<212>  PRT
<213>  Homosapiens

<400>  20

Met Ala Ala Ser Gly Lys Thr Ser Lys Ser Glu Pro Asn His Val Ile 
1               5                   10                  15      


Phe Lys Lys Ile Ser Arg Asp Lys Ser Val Thr Ile Tyr Leu Gly Asn 
            20                  25                  30          


Arg Asp Tyr Ile Asp His Val Ser Gln Val Gln Pro Val Asp Gly Val 
        35                  40                  45              


Val Leu Val Asp Pro Asp Leu Val Lys Gly Lys Lys Val Tyr Val Thr 
    50                  55                  60                  


Leu Thr Cys Ala Phe Arg Tyr Gly Gln Glu Asp Ile Asp Val Ile Gly 
65                  70                  75                  80  


Leu Thr Phe Arg Arg Asp Leu Tyr Phe Ser Arg Val Gln Val Tyr Pro 
                85                  90                  95      


Pro Val Gly Ala Ala Ser Thr Pro Thr Lys Leu Gln Glu Ser Leu Leu 
            100                 105                 110         


Lys Lys Leu Gly Ser Asn Thr Tyr Pro Phe Leu Leu Thr Phe Pro Asp 
        115                 120                 125             


Tyr Leu Pro Cys Ser Val Met Leu Gln Pro Ala Pro Gln Asp Ser Gly 
    130                 135                 140                 


Lys Ser Cys Gly Val Asp Phe Glu Val Lys Ala Phe Ala Thr Asp Ser 
145                 150                 155                 160 


Thr Asp Ala Glu Glu Asp Lys Ile Pro Lys Lys Ser Ser Val Arg Leu 
                165                 170                 175     


Leu Ile Arg Lys Val Gln His Ala Pro Leu Glu Met Gly Pro Gln Pro 
            180                 185                 190         


Arg Ala Glu Ala Ala Trp Gln Phe Phe Met Ser Asp Lys Pro Leu His 
        195                 200                 205             


Leu Ala Val Ser Leu Asn Lys Glu Ile Tyr Phe His Gly Glu Pro Ile 
    210                 215                 220                 


Pro Val Thr Val Thr Val Thr Asn Asn Thr Glu Lys Thr Val Lys Lys 
225                 230                 235                 240 


Ile Lys Ala Phe Val Glu Gln Val Ala Asn Val Val Leu Tyr Ser Ser 
                245                 250                 255     


Asp Tyr Tyr Val Lys Pro Val Ala Met Glu Glu Ala Gln Glu Lys Val 
            260                 265                 270         


Pro Pro Asn Ser Thr Leu Thr Lys Thr Leu Thr Leu Leu Pro Leu Leu 
        275                 280                 285             


Ala Asn Asn Arg Glu Arg Arg Gly Ile Ala Leu Asp Gly Lys Ile Lys 
    290                 295                 300                 


His Glu Asp Thr Asn Leu Ala Ser Ser Thr Ile Ile Lys Glu Gly Ile 
305                 310                 315                 320 


Asp Arg Thr Val Leu Gly Ile Leu Val Ser Tyr Gln Ile Lys Val Lys 
                325                 330                 335     


Leu Thr Val Ser Gly Phe Leu Gly Glu Leu Thr Ser Ser Glu Val Ala 
            340                 345                 350         


Thr Glu Val Pro Phe Arg Leu Met His Pro Gln Pro Glu Asp Pro Ala 
        355                 360                 365             


Lys Glu Ser Tyr Gln Asp Ala Asn Leu Val Phe Glu Glu Phe Ala Arg 
    370                 375                 380                 


His Asn Leu Lys Asp Ala Gly Glu Ala Glu Glu Gly Lys Arg Asp Lys 
385                 390                 395                 400 


Asn Asp Ala Asp Glu 
                405 


<210>  21
<211>  6229
<212>  DNA
<213>  Homosapiens

<400>  21
agagacacga atatgtttca gccgcaacag gctgcgtttc agccggaaga gtgaaagggc     60

accttgaaaa cgcaagttta tgaatatgtt tctgtacttt cagaccatca tcaaagaggg    120

gatgctgacc aaacagaaca attcattcca gcgatcaaaa aggagatact ttaagcttcg    180

agggcgaacg ctttactatg ccaaaacggc aaagtcaatc atatttgatg aggtggatct    240

gacagatgcc agcgtagctg aatccagtac caaaaacgtc aacaacagtt ttacggtcat    300

aactccatgc aggaagctca tcttgtgtgc tgataacaga aaagaaatgg aagattggat    360

tgcagcatta aagactgtgc agaacaggga gcactttgag cccacccagt acagcatgga    420

ccacttctca gggatgcaca attggtacgc ctgttcccac gcgaggccga cctactgcaa    480

tgtgtgccgt gaggctctgt ctggggtcac gtcgcacggg ctgtcctgcg aggtgtgcaa    540

atttaaggcc cacaagcgct gtgctgtgcg tgcaaccaat aactgcaagt ggaccacact    600

ggcctcgatc gggaaggaca tcattgaaga tgcagatggg attgcaatgc cccaccagtg    660

gttggaagga aacctacctg tgagcgccaa gtgcactgtg tgcgacaaga cctgtggcag    720

tgtgctgcgc ctgcaggact ggcgctgcct ctggtgcaag gccatggttc acacatcgtg    780

taaagaatcc ttgctgacca agtgcccact tggcctgtgc aaagtgtcag tcatcccacc    840

cacggctctc aacagcatcg actccgatgg gttctggaag gccagctgtc ctccttcttg    900

cacaagccca ctgttggtct tcgtcaattc aaaaagtggg gacaaccagg gtgtgaagtt    960

cctcagaaga ttcaaacagc tactaaaccc cgcccaggtc ttcgacctca tgaacggagg   1020

cccacacctc ggcttacggt tattccagaa gtttgacaca ttccggattc tggtttgtgg   1080

cggggatgga agtgttggct gggtcctctc cgaaatcgac agcctcaacc ttcataaaca   1140

gtgtcagctg ggagtgctgc cgctcggcac agggaacgac ttggcccgag tactgggctg   1200

gggctcagcc tgcgatgacg acacccagct cccccagatc ttggagaagt tggagagagc   1260

cagcaccaag atgctggaca ggtggagcgt catggcatac gaggccaagc tcccccggca   1320

ggcctcctcc tctaccgtca ccgaagactt cagcgaggat tccgaggtac agcagattct   1380

cttctatgaa gactcggttg cagcccacct ttctaaaatc ctcacctcgg accagcactc   1440

ggtggtcatc tcctcggcca aagtgctctg tgagacggtg aaggacttcg tggcacgggt   1500

ggggaaggcc tatgagaaga cgaccgagag ctcggaggag tcagaggtca tggccaagaa   1560

gtgctctgtc ctgaaagaga agctggattc ccttctcaag accttggacg atgagtccca   1620

ggcctcgtcc tctctgccca acccgccccc caccattgcc gaggaggctg aagatggaga   1680

tgggtcgggc agcatctgcg gttccaccgg agaccgcttg gtggcatcag cttgcccggc   1740

ccggccgcag atattccggc ctcgagaaca gctcatgctg agagccaaca gcctgaagaa   1800

agcaattcgt cagatcatag aacacacaga aaaagctgtc gatgagcaga atgcccagac   1860

ccaggagcag gagggcttcg tcctgggcct ctctgagtca gaggagaaga tggaccacag   1920

agtgtgccca ccactgtccc acagcgagag cttcggggtc cccaagggga ggagccagcg   1980

caaagtgtcg aaatctccgt gtgaaaagct gatcagcaaa gggagtctgt ccctaggcag   2040

ttctgcttcc cttccgcccc agccgggaag ccgggacggc ctgcctgcgc tcaacaccaa   2100

gatcctgtac ccaaatgtcc gggctggaat gtctggttcc ttacccggtg gctcagtcat   2160

cagtcgcctg ttaattaatg ctgatccctt caactctgaa ccagaaaccc tagagtatta   2220

cacggagaaa tgtgtcatga acaactattt tggcattggc ctggatgcga agatatccct   2280

ggactttaac aacaagcgcg atgagcaccc agagaagtgc aggagccgaa ccaagaacat   2340

gatgtggtat ggagttcttg gaaccaaaga gttgctgcac agaacctaca agaacctgga   2400

gcaaaaggtc ttgctggagt gtgacgggcg acccatccca ctccccagtc ttcagggaat   2460

tgctgtcctt aacattccca gctatgccgg aggaaccaac ttctgggggg gtaccaagga   2520

agatgatact ttcgcagctc catcattcga tgacaagatt ctggaggtgg tcgccgtgtt   2580

cggcagcatg cagatggccg tctctcgagt catcaggcta cagcatcatc ggatcgccca   2640

gtgtcgcacg gtgaagatct ccatccttgg ggatgagggc gtgcctgtgc aggtggacgg   2700

agaggcctgg gtccagccgc cagggtacat tcggattgtc cacaagaacc gggcacagac   2760

actgaccaga gacagggcat ttgagagcac cctgaagtcc tgggaagaca agcagaagtg   2820

cgagctgccc cgccctccat cctgttccct gcacccggag atgctgtccg aggaggaggc   2880

cacccagatg gaccagtttg ggcaggcagc aggggtcctc attcacagta tccgagaaat   2940

agctcagtct caccgggaca tggagcagga actggcccac gccgtcaatg ccagctccaa   3000

gtccatggac cgtgtgtatg gcaagcccag aaccacagag gggctcaact gcagcttcgt   3060

cctggaaatg gtgaataact tcagagctct gcgcagtgag acggagctgc tgctgtctgg   3120

gaagatggcc ctgcagctgg atccgcctca gaaggagcag ctggggagtg ctcttgccga   3180

gatggaccga cagctcagga ggctggcaga caccccgtgg ctctgccagt ccgcagagcc   3240

cggcgacgaa gagagtgtga tgctggatct tgccaagcgc agtcgcagtg gtaaattccg   3300

cctcgtgacc aagtttaaaa aggagaaaaa caacaagaac aaagaagctc acagtagcct   3360

gggagccccg gttcacctct gggggacaga ggaggttgct gcctggctgg agcacctcag   3420

tctctgtgag tataaggaca tcttcacacg gcacgacatc cggggctctg agctcctgca   3480

cctggagcgg agggacctca aggacctggg cgtgaccaag gtgggccaca tgaagaggat   3540

cctgtgtggc atcaaggagc tgagccgcag cgcccccgcc gtcgaggcct agcctctgtc   3600

ctctcagcct gtggcctcca catccccgcc gccgaggcct agcctccgcc ctctcagcct   3660

gtggcctctg cgcctcctgc cactgaggcc ctgggcagat gctgcagccc gcccccttct   3720

catggtgcta cttcctctgt cagctacaga aagcctccgt gacaccgtcc accagagctc   3780

tggggtctcg aacataacaa cacagctacc tttgaaacaa cactttctcc agctcagagt   3840

cacctggggc acatgtgtca cggccactca gctctcgccc gcctgtgctg tgggccaggg   3900

aatccagcgg cgtctggcct cctgggcact gcttgcctgg cctcgtgctt ggattgtccc   3960

gggggctcct ctccgtgtgt ccttctgtgg ccgcaccgtg tggctccgcc tcctggcccc   4020

cagccagttc tcagaaacgt ggctggggcc cagcacagca gcctgcaagg gcccctgttt   4080

gttgatgcag cttttgttga acaaaaatcg tgctctttcc tggtttgaaa gtagcatgga   4140

tgtttccagt cttgttgatt gtaatttgac gtgaagagaa aaaaaaattc ctcctgcgtg   4200

agccaaggca gcgggtgctg tttcccaggc ggggagcccc tccctgggtg tcacagggcc   4260

tgtgctcctc cctcctccat cctctctcct cccgctcctc cctcccccca ctgtgggctg   4320

gggacgcctg cccttctgtc tccggacgct ctaggcgagt tcagcttggg gtgtgagtga   4380

gacagcttgc cagctgcatc cctgcagaca gaggatgtgt gtccacatga gtgtttctgt   4440

gtgggaaatg cttcctggct ctgggaaact ttttctgccc attctgtggt tcccagggag   4500

cgtggccctg gtgggccagg ggtggtttga cctcttcagc ccgtccggtg gcctggaggc   4560

cggaggctct cctgagtgtc tgcccctgca gtggcttctt gtcgcctgct gctgggcgtg   4620

atgtcgctgg aggtgctggc agggactctg atttggtggt ccgcgctgcc cctgccctgc   4680

ctctgtcctg gctctgaact agtagatgat ggtgccagag ggcagggagc tcgcctgggg   4740

agagggctgt gccccgtagg gacagtgccc aggtgaagga tgcccctggt cctccagggc   4800

actgactttg cccttttttc ccgttgatag tcatggctca gaggtgcttg taaatgtctt   4860

gggaagaggt ttctgtaacc cctgccctgg tgtgaggagg aaatggctct ggcctggctg   4920

cctggccgtg gcttctcttt ggctcccaaa gagaaggaca gtgttgggag tatctgccgt   4980

ggcttctctt tggctcccaa agagaaggac agtgttggga gtatctgccg gcgctgtcca   5040

ggtcctttag tcagcgtcac tccatctgat gtgcagaagc tgggctgcac ctgcgggggt   5100

gggcatagac cgggctgggt ctgcagcagc ccctggtcct gagcaggcgg cagtgaacag   5160

cactggccca cctcccactc acagcccctc tgtcccctct gcagtgcacc caggtgggcc   5220

cctctgcgtg cctttgggtg ctcccctctc gtggtcgttc tggcccgagg cccttagagt   5280

atggaggctg agccaggcct tgggtttccc cagcacagcc tcctgtcgct gcatgcgacg   5340

tgttgggatt tttggatgaa agactctccc acgctctgtt ggtggactta gctgcctcac   5400

tggaagtgat gtgggtggaa ggtggttgta tgttaccttt tccacctctc attgttttcc   5460

ccagaacatt gtagatgggg gttggcagag ggagaaataa gccagccacg gcagtcgctt   5520

ggtttcccag gtggaatggg ctaacacagg agatgatggg aacctgtccc gcagtccctg   5580

catgaccatt ggccctgctg gcctggcgat gtgggcatcc tggggttctt agggtcccag   5640

aacaagcccc aggcaagctg gaacttgggt ggggagggga catgaggagg ataaacagct   5700

gactgtggct tcaaggacat cagggccacc ccaagtcctc agtgtcctac tcctggcaag   5760

gagttgggtt tggatcaaaa gtgtttaaaa ttaatatgtt gtcagtgatt agaacaacac   5820

tgtttacata aaaaccattt ttctaattct aacaagttag aatgtgagga aggaatgaac   5880

atgagtgttt aggaacctgc cctttggtgc tgggctggcg tcccgcactg gggtgtcctc   5940

gctgtctggg ggctgctctg ctgccccggc ccaggtcccc ttgtggtgtt gccagacggg   6000

cctcatggtc tgctgtgcag agagaggcag gaaggatccc tgaagagtct tggagaaaag   6060

gttctgtgcc ctcaggtggg gcttaccccc tcgtatttat aatcttaatt tatatagtga   6120

ccaccgtgga aacaaacgcc tcttgtattg tcatgtacat agtccatacc tgagtgctgt   6180

acataagttg ttctgtgtat aaataaaaca agcctgtttt tgatcttcc               6229


<210>  22
<211>  1170
<212>  PRT
<213>  Homosapiens

<400>  22

Met Asn Met Phe Leu Tyr Phe Gln Thr Ile Ile Lys Glu Gly Met Leu 
1               5                   10                  15      


Thr Lys Gln Asn Asn Ser Phe Gln Arg Ser Lys Arg Arg Tyr Phe Lys 
            20                  25                  30          


Leu Arg Gly Arg Thr Leu Tyr Tyr Ala Lys Thr Ala Lys Ser Ile Ile 
        35                  40                  45              


Phe Asp Glu Val Asp Leu Thr Asp Ala Ser Val Ala Glu Ser Ser Thr 
    50                  55                  60                  


Lys Asn Val Asn Asn Ser Phe Thr Val Ile Thr Pro Cys Arg Lys Leu 
65                  70                  75                  80  


Ile Leu Cys Ala Asp Asn Arg Lys Glu Met Glu Asp Trp Ile Ala Ala 
                85                  90                  95      


Leu Lys Thr Val Gln Asn Arg Glu His Phe Glu Pro Thr Gln Tyr Ser 
            100                 105                 110         


Met Asp His Phe Ser Gly Met His Asn Trp Tyr Ala Cys Ser His Ala 
        115                 120                 125             


Arg Pro Thr Tyr Cys Asn Val Cys Arg Glu Ala Leu Ser Gly Val Thr 
    130                 135                 140                 


Ser His Gly Leu Ser Cys Glu Val Cys Lys Phe Lys Ala His Lys Arg 
145                 150                 155                 160 


Cys Ala Val Arg Ala Thr Asn Asn Cys Lys Trp Thr Thr Leu Ala Ser 
                165                 170                 175     


Ile Gly Lys Asp Ile Ile Glu Asp Ala Asp Gly Ile Ala Met Pro His 
            180                 185                 190         


Gln Trp Leu Glu Gly Asn Leu Pro Val Ser Ala Lys Cys Thr Val Cys 
        195                 200                 205             


Asp Lys Thr Cys Gly Ser Val Leu Arg Leu Gln Asp Trp Arg Cys Leu 
    210                 215                 220                 


Trp Cys Lys Ala Met Val His Thr Ser Cys Lys Glu Ser Leu Leu Thr 
225                 230                 235                 240 


Lys Cys Pro Leu Gly Leu Cys Lys Val Ser Val Ile Pro Pro Thr Ala 
                245                 250                 255     


Leu Asn Ser Ile Asp Ser Asp Gly Phe Trp Lys Ala Ser Cys Pro Pro 
            260                 265                 270         


Ser Cys Thr Ser Pro Leu Leu Val Phe Val Asn Ser Lys Ser Gly Asp 
        275                 280                 285             


Asn Gln Gly Val Lys Phe Leu Arg Arg Phe Lys Gln Leu Leu Asn Pro 
    290                 295                 300                 


Ala Gln Val Phe Asp Leu Met Asn Gly Gly Pro His Leu Gly Leu Arg 
305                 310                 315                 320 


Leu Phe Gln Lys Phe Asp Thr Phe Arg Ile Leu Val Cys Gly Gly Asp 
                325                 330                 335     


Gly Ser Val Gly Trp Val Leu Ser Glu Ile Asp Ser Leu Asn Leu His 
            340                 345                 350         


Lys Gln Cys Gln Leu Gly Val Leu Pro Leu Gly Thr Gly Asn Asp Leu 
        355                 360                 365             


Ala Arg Val Leu Gly Trp Gly Ser Ala Cys Asp Asp Asp Thr Gln Leu 
    370                 375                 380                 


Pro Gln Ile Leu Glu Lys Leu Glu Arg Ala Ser Thr Lys Met Leu Asp 
385                 390                 395                 400 


Arg Trp Ser Val Met Ala Tyr Glu Ala Lys Leu Pro Arg Gln Ala Ser 
                405                 410                 415     


Ser Ser Thr Val Thr Glu Asp Phe Ser Glu Asp Ser Glu Val Gln Gln 
            420                 425                 430         


Ile Leu Phe Tyr Glu Asp Ser Val Ala Ala His Leu Ser Lys Ile Leu 
        435                 440                 445             


Thr Ser Asp Gln His Ser Val Val Ile Ser Ser Ala Lys Val Leu Cys 
    450                 455                 460                 


Glu Thr Val Lys Asp Phe Val Ala Arg Val Gly Lys Ala Tyr Glu Lys 
465                 470                 475                 480 


Thr Thr Glu Ser Ser Glu Glu Ser Glu Val Met Ala Lys Lys Cys Ser 
                485                 490                 495     


Val Leu Lys Glu Lys Leu Asp Ser Leu Leu Lys Thr Leu Asp Asp Glu 
            500                 505                 510         


Ser Gln Ala Ser Ser Ser Leu Pro Asn Pro Pro Pro Thr Ile Ala Glu 
        515                 520                 525             


Glu Ala Glu Asp Gly Asp Gly Ser Gly Ser Ile Cys Gly Ser Thr Gly 
    530                 535                 540                 


Asp Arg Leu Val Ala Ser Ala Cys Pro Ala Arg Pro Gln Ile Phe Arg 
545                 550                 555                 560 


Pro Arg Glu Gln Leu Met Leu Arg Ala Asn Ser Leu Lys Lys Ala Ile 
                565                 570                 575     


Arg Gln Ile Ile Glu His Thr Glu Lys Ala Val Asp Glu Gln Asn Ala 
            580                 585                 590         


Gln Thr Gln Glu Gln Glu Gly Phe Val Leu Gly Leu Ser Glu Ser Glu 
        595                 600                 605             


Glu Lys Met Asp His Arg Val Cys Pro Pro Leu Ser His Ser Glu Ser 
    610                 615                 620                 


Phe Gly Val Pro Lys Gly Arg Ser Gln Arg Lys Val Ser Lys Ser Pro 
625                 630                 635                 640 


Cys Glu Lys Leu Ile Ser Lys Gly Ser Leu Ser Leu Gly Ser Ser Ala 
                645                 650                 655     


Ser Leu Pro Pro Gln Pro Gly Ser Arg Asp Gly Leu Pro Ala Leu Asn 
            660                 665                 670         


Thr Lys Ile Leu Tyr Pro Asn Val Arg Ala Gly Met Ser Gly Ser Leu 
        675                 680                 685             


Pro Gly Gly Ser Val Ile Ser Arg Leu Leu Ile Asn Ala Asp Pro Phe 
    690                 695                 700                 


Asn Ser Glu Pro Glu Thr Leu Glu Tyr Tyr Thr Glu Lys Cys Val Met 
705                 710                 715                 720 


Asn Asn Tyr Phe Gly Ile Gly Leu Asp Ala Lys Ile Ser Leu Asp Phe 
                725                 730                 735     


Asn Asn Lys Arg Asp Glu His Pro Glu Lys Cys Arg Ser Arg Thr Lys 
            740                 745                 750         


Asn Met Met Trp Tyr Gly Val Leu Gly Thr Lys Glu Leu Leu His Arg 
        755                 760                 765             


Thr Tyr Lys Asn Leu Glu Gln Lys Val Leu Leu Glu Cys Asp Gly Arg 
    770                 775                 780                 


Pro Ile Pro Leu Pro Ser Leu Gln Gly Ile Ala Val Leu Asn Ile Pro 
785                 790                 795                 800 


Ser Tyr Ala Gly Gly Thr Asn Phe Trp Gly Gly Thr Lys Glu Asp Asp 
                805                 810                 815     


Thr Phe Ala Ala Pro Ser Phe Asp Asp Lys Ile Leu Glu Val Val Ala 
            820                 825                 830         


Val Phe Gly Ser Met Gln Met Ala Val Ser Arg Val Ile Arg Leu Gln 
        835                 840                 845             


His His Arg Ile Ala Gln Cys Arg Thr Val Lys Ile Ser Ile Leu Gly 
    850                 855                 860                 


Asp Glu Gly Val Pro Val Gln Val Asp Gly Glu Ala Trp Val Gln Pro 
865                 870                 875                 880 


Pro Gly Tyr Ile Arg Ile Val His Lys Asn Arg Ala Gln Thr Leu Thr 
                885                 890                 895     


Arg Asp Arg Ala Phe Glu Ser Thr Leu Lys Ser Trp Glu Asp Lys Gln 
            900                 905                 910         


Lys Cys Glu Leu Pro Arg Pro Pro Ser Cys Ser Leu His Pro Glu Met 
        915                 920                 925             


Leu Ser Glu Glu Glu Ala Thr Gln Met Asp Gln Phe Gly Gln Ala Ala 
    930                 935                 940                 


Gly Val Leu Ile His Ser Ile Arg Glu Ile Ala Gln Ser His Arg Asp 
945                 950                 955                 960 


Met Glu Gln Glu Leu Ala His Ala Val Asn Ala Ser Ser Lys Ser Met 
                965                 970                 975     


Asp Arg Val Tyr Gly Lys Pro Arg Thr Thr Glu Gly Leu Asn Cys Ser 
            980                 985                 990         


Phe Val Leu Glu Met Val Asn Asn  Phe Arg Ala Leu Arg  Ser Glu Thr 
        995                 1000                 1005             


Glu Leu  Leu Leu Ser Gly Lys  Met Ala Leu Gln Leu  Asp Pro Pro 
    1010                 1015                 1020             


Gln Lys  Glu Gln Leu Gly Ser  Ala Leu Ala Glu Met  Asp Arg Gln 
    1025                 1030                 1035             


Leu Arg  Arg Leu Ala Asp Thr  Pro Trp Leu Cys Gln  Ser Ala Glu 
    1040                 1045                 1050             


Pro Gly  Asp Glu Glu Ser Val  Met Leu Asp Leu Ala  Lys Arg Ser 
    1055                 1060                 1065             


Arg Ser  Gly Lys Phe Arg Leu  Val Thr Lys Phe Lys  Lys Glu Lys 
    1070                 1075                 1080             


Asn Asn  Lys Asn Lys Glu Ala  His Ser Ser Leu Gly  Ala Pro Val 
    1085                 1090                 1095             


His Leu  Trp Gly Thr Glu Glu  Val Ala Ala Trp Leu  Glu His Leu 
    1100                 1105                 1110             


Ser Leu  Cys Glu Tyr Lys Asp  Ile Phe Thr Arg His  Asp Ile Arg 
    1115                 1120                 1125             


Gly Ser  Glu Leu Leu His Leu  Glu Arg Arg Asp Leu  Lys Asp Leu 
    1130                 1135                 1140             


Gly Val  Thr Lys Val Gly His  Met Lys Arg Ile Leu  Cys Gly Ile 
    1145                 1150                 1155             


Lys Glu  Leu Ser Arg Ser Ala  Pro Ala Val Glu Ala  
    1160                 1165                 1170 


<210>  23
<211>  6294
<212>  DNA
<213>  Homosapiens

<400>  23
tggcccggca gcatggcggc ggcggcgggc gcccctccgc cgggtccccc gcaaccgcct     60

ccgccgccgc cgcccgagga gtcgtccgac agcgagcccg aggcggagcc cggctcccca    120

cagaagctca tccgcaaggt gtccacgtcg ggtcagatcc gacagaagac catcatcaaa    180

gaggggatgc tgaccaaaca gaacaattca ttccagcgat caaaaaggag atactttaag    240

cttcgagggc gaacgcttta ctatgccaaa acggcaaagt caatcatatt tgatgaggtg    300

gatctgacag atgccagcgt agctgaatcc agtaccaaaa acgtcaacaa cagttttacg    360

gtcataactc catgcaggaa gctcatcttg tgtgctgata acagaaaaga aatggaagat    420

tggattgcag cattaaagac tgtgcagaac agggagcact ttgagcccac ccagtacagc    480

atggaccact tctcagggat gcacaattgg tacgcctgtt cccacgcgag gccgacctac    540

tgcaatgtgt gccgtgaggc tctgtctggg gtcacgtcgc acgggctgtc ctgcgaggtg    600

tgcaaattta aggcccacaa gcgctgtgct gtgcgtgcaa ccaataactg caagtggacc    660

acactggcct cgatcgggaa ggacatcatt gaagatgcag atgggattgc aatgccccac    720

cagtggttgg aaggaaacct acctgtgagc gccaagtgca ctgtgtgcga caagacctgt    780

ggcagtgtgc tgcgcctgca ggactggcgc tgcctctggt gcaaggccat ggttcacaca    840

tcgtgtaaag aatccttgct gaccaagtgc ccacttggcc tgtgcaaagt gtcagtcatc    900

ccacccacgg ctctcaacag catcgactcc gatgggttct ggaaggccag ctgtcctcct    960

tcttgcacaa gcccactgtt ggtcttcgtc aattcaaaaa gtggggacaa ccagggtgtg   1020

aagttcctca gaagattcaa acagctacta aaccccgccc aggtcttcga cctcatgaac   1080

ggaggcccac acctcggctt acggttattc cagaagtttg acacattccg gattctggtt   1140

tgtggcgggg atggaagtgt tggctgggtc ctctccgaaa tcgacagcct caaccttcat   1200

aaacagtgtc agctgggagt gctgccgctc ggcacaggga acgacttggc ccgagtactg   1260

ggctggggct cagcctgcga tgacgacacc cagctccccc agatcttgga gaagttggag   1320

agagccagca ccaagatgct ggacaggtgg agcgtcatgg catacgaggc caagctcccc   1380

cggcaggcct cctcctctac cgtcaccgaa gacttcagcg aggattccga ggtacagcag   1440

attctcttct atgaagactc ggttgcagcc cacctttcta aaatcctcac ctcggaccag   1500

cactcggtgg tcatctcctc ggccaaagtg ctctgtgaga cggtgaagga cttcgtggca   1560

cgggtgggga aggcctatga gaagacgacc gagagctcgg aggagtcaga ggtcatggcc   1620

aagaagtgct ctgtcctgaa agagaagctg gattcccttc tcaagacctt ggacgatgag   1680

tcccaggcct cgtcctctct gcccaacccg ccccccacca ttgccgagga ggctgaagat   1740

ggagatgggt cgggcagcat ctgcggttcc accggagacc gcttggtggc atcagcttgc   1800

ccggcccggc cgcagatatt ccggcctcga gaacagctca tgctgagagc caacagcctg   1860

aagaaagcaa ttcgtcagat catagaacac acagaaaaag ctgtcgatga gcagaatgcc   1920

cagacccagg agcaggaggg cttcgtcctg ggcctctctg agtcagagga gaagatggac   1980

cacagagtgt gcccaccact gtcccacagc gagagcttcg gggtccccaa ggggaggagc   2040

cagcgcaaag tgtcgaaatc tccgtgtgaa aagctgatca gcaaagggag tctgtcccta   2100

ggcagttctg cttcccttcc gccccagccg ggaagccggg acggcctgcc tgcgctcaac   2160

accaagatcc tgtacccaaa tgtccgggct ggaatgtctg gttccttacc cggtggctca   2220

gtcatcagtc gcctgttaat taatgctgat cccttcaact ctgaaccaga aaccctagag   2280

tattacacgg agaaatgtgt catgaacaac tattttggca ttggcctgga tgcgaagata   2340

tccctggact ttaacaacaa gcgcgatgag cacccagaga agtgcaggag ccgaaccaag   2400

aacatgatgt ggtatggagt tcttggaacc aaagagttgc tgcacagaac ctacaagaac   2460

ctggagcaaa aggtcttgct ggagtgtgac gggcgaccca tcccactccc cagtcttcag   2520

ggaattgctg tccttaacat tcccagctat gccggaggaa ccaacttctg ggggggtacc   2580

aaggaagatg atactttcgc agctccatca ttcgatgaca agattctgga ggtggtcgcc   2640

gtgttcggca gcatgcagat ggccgtctct cgagtcatca ggctacagca tcatcggatc   2700

gcccagtgtc gcacggtgaa gatctccatc cttggggatg agggcgtgcc tgtgcaggtg   2760

gacggagagg cctgggtcca gccgccaggg tacattcgga ttgtccacaa gaaccgggca   2820

cagacactga ccagagacag ggcatttgag agcaccctga agtcctggga agacaagcag   2880

aagtgcgagc tgccccgccc tccatcctgt tccctgcacc cggagatgct gtccgaggag   2940

gaggccaccc agatggacca gtttgggcag gcagcagggg tcctcattca cagtatccga   3000

gaaatagctc agtctcaccg ggacatggag caggaactgg cccacgccgt caatgccagc   3060

tccaagtcca tggaccgtgt gtatggcaag cccagaacca cagaggggct caactgcagc   3120

ttcgtcctgg aaatggtgaa taacttcaga gctctgcgca gtgagacgga gctgctgctg   3180

tctgggaaga tggccctgca gctggatccg cctcagaagg agcagctggg gagtgctctt   3240

gccgagatgg accgacagct caggaggctg gcagacaccc cgtggctctg ccagtccgca   3300

gagcccggcg acgaagagag tgtgatgctg gatcttgcca agcgcagtcg cagtggtaaa   3360

ttccgcctcg tgaccaagtt taaaaaggag aaaaacaaca agaacaaaga agctcacagt   3420

agcctgggag ccccggttca cctctggggg acagaggagg ttgctgcctg gctggagcac   3480

ctcagtctct gtgagtataa ggacatcttc acacggcacg acatccgggg ctctgagctc   3540

ctgcacctgg agcggaggga cctcaaggac ctgggcgtga ccaaggtggg ccacatgaag   3600

aggatcctgt gtggcatcaa ggagctgagc cgcagcgccc ccgccgtcga ggcctagcct   3660

ctgtcctctc agcctgtggc ctccacatcc ccgccgccga ggcctagcct ccgccctctc   3720

agcctgtggc ctctgcgcct cctgccactg aggccctggg cagatgctgc agcccgcccc   3780

cttctcatgg tgctacttcc tctgtcagct acagaaagcc tccgtgacac cgtccaccag   3840

agctctgggg tctcgaacat aacaacacag ctacctttga aacaacactt tctccagctc   3900

agagtcacct ggggcacatg tgtcacggcc actcagctct cgcccgcctg tgctgtgggc   3960

cagggaatcc agcggcgtct ggcctcctgg gcactgcttg cctggcctcg tgcttggatt   4020

gtcccggggg ctcctctccg tgtgtccttc tgtggccgca ccgtgtggct ccgcctcctg   4080

gcccccagcc agttctcaga aacgtggctg gggcccagca cagcagcctg caagggcccc   4140

tgtttgttga tgcagctttt gttgaacaaa aatcgtgctc tttcctggtt tgaaagtagc   4200

atggatgttt ccagtcttgt tgattgtaat ttgacgtgaa gagaaaaaaa aattcctcct   4260

gcgtgagcca aggcagcggg tgctgtttcc caggcgggga gcccctccct gggtgtcaca   4320

gggcctgtgc tcctccctcc tccatcctct ctcctcccgc tcctccctcc ccccactgtg   4380

ggctggggac gcctgccctt ctgtctccgg acgctctagg cgagttcagc ttggggtgtg   4440

agtgagacag cttgccagct gcatccctgc agacagagga tgtgtgtcca catgagtgtt   4500

tctgtgtggg aaatgcttcc tggctctggg aaactttttc tgcccattct gtggttccca   4560

gggagcgtgg ccctggtggg ccaggggtgg tttgacctct tcagcccgtc cggtggcctg   4620

gaggccggag gctctcctga gtgtctgccc ctgcagtggc ttcttgtcgc ctgctgctgg   4680

gcgtgatgtc gctggaggtg ctggcaggga ctctgatttg gtggtccgcg ctgcccctgc   4740

cctgcctctg tcctggctct gaactagtag atgatggtgc cagagggcag ggagctcgcc   4800

tggggagagg gctgtgcccc gtagggacag tgcccaggtg aaggatgccc ctggtcctcc   4860

agggcactga ctttgccctt ttttcccgtt gatagtcatg gctcagaggt gcttgtaaat   4920

gtcttgggaa gaggtttctg taacccctgc cctggtgtga ggaggaaatg gctctggcct   4980

ggctgcctgg ccgtggcttc tctttggctc ccaaagagaa ggacagtgtt gggagtatct   5040

gccgtggctt ctctttggct cccaaagaga aggacagtgt tgggagtatc tgccggcgct   5100

gtccaggtcc tttagtcagc gtcactccat ctgatgtgca gaagctgggc tgcacctgcg   5160

ggggtgggca tagaccgggc tgggtctgca gcagcccctg gtcctgagca ggcggcagtg   5220

aacagcactg gcccacctcc cactcacagc ccctctgtcc cctctgcagt gcacccaggt   5280

gggcccctct gcgtgccttt gggtgctccc ctctcgtggt cgttctggcc cgaggccctt   5340

agagtatgga ggctgagcca ggccttgggt ttccccagca cagcctcctg tcgctgcatg   5400

cgacgtgttg ggatttttgg atgaaagact ctcccacgct ctgttggtgg acttagctgc   5460

ctcactggaa gtgatgtggg tggaaggtgg ttgtatgtta ccttttccac ctctcattgt   5520

tttccccaga acattgtaga tgggggttgg cagagggaga aataagccag ccacggcagt   5580

cgcttggttt cccaggtgga atgggctaac acaggagatg atgggaacct gtcccgcagt   5640

ccctgcatga ccattggccc tgctggcctg gcgatgtggg catcctgggg ttcttagggt   5700

cccagaacaa gccccaggca agctggaact tgggtgggga ggggacatga ggaggataaa   5760

cagctgactg tggcttcaag gacatcaggg ccaccccaag tcctcagtgt cctactcctg   5820

gcaaggagtt gggtttggat caaaagtgtt taaaattaat atgttgtcag tgattagaac   5880

aacactgttt acataaaaac catttttcta attctaacaa gttagaatgt gaggaaggaa   5940

tgaacatgag tgtttaggaa cctgcccttt ggtgctgggc tggcgtcccg cactggggtg   6000

tcctcgctgt ctgggggctg ctctgctgcc ccggcccagg tccccttgtg gtgttgccag   6060

acgggcctca tggtctgctg tgcagagaga ggcaggaagg atccctgaag agtcttggag   6120

aaaaggttct gtgccctcag gtggggctta ccccctcgta tttataatct taatttatat   6180

agtgaccacc gtggaaacaa acgcctcttg tattgtcatg tacatagtcc atacctgagt   6240

gctgtacata agttgttctg tgtataaata aaacaagcct gtttttgatc ttcc         6294


<210>  24
<211>  1214
<212>  PRT
<213>  Homosapiens

<400>  24

Met Ala Ala Ala Ala Gly Ala Pro Pro Pro Gly Pro Pro Gln Pro Pro 
1               5                   10                  15      


Pro Pro Pro Pro Pro Glu Glu Ser Ser Asp Ser Glu Pro Glu Ala Glu 
            20                  25                  30          


Pro Gly Ser Pro Gln Lys Leu Ile Arg Lys Val Ser Thr Ser Gly Gln 
        35                  40                  45              


Ile Arg Gln Lys Thr Ile Ile Lys Glu Gly Met Leu Thr Lys Gln Asn 
    50                  55                  60                  


Asn Ser Phe Gln Arg Ser Lys Arg Arg Tyr Phe Lys Leu Arg Gly Arg 
65                  70                  75                  80  


Thr Leu Tyr Tyr Ala Lys Thr Ala Lys Ser Ile Ile Phe Asp Glu Val 
                85                  90                  95      


Asp Leu Thr Asp Ala Ser Val Ala Glu Ser Ser Thr Lys Asn Val Asn 
            100                 105                 110         


Asn Ser Phe Thr Val Ile Thr Pro Cys Arg Lys Leu Ile Leu Cys Ala 
        115                 120                 125             


Asp Asn Arg Lys Glu Met Glu Asp Trp Ile Ala Ala Leu Lys Thr Val 
    130                 135                 140                 


Gln Asn Arg Glu His Phe Glu Pro Thr Gln Tyr Ser Met Asp His Phe 
145                 150                 155                 160 


Ser Gly Met His Asn Trp Tyr Ala Cys Ser His Ala Arg Pro Thr Tyr 
                165                 170                 175     


Cys Asn Val Cys Arg Glu Ala Leu Ser Gly Val Thr Ser His Gly Leu 
            180                 185                 190         


Ser Cys Glu Val Cys Lys Phe Lys Ala His Lys Arg Cys Ala Val Arg 
        195                 200                 205             


Ala Thr Asn Asn Cys Lys Trp Thr Thr Leu Ala Ser Ile Gly Lys Asp 
    210                 215                 220                 


Ile Ile Glu Asp Ala Asp Gly Ile Ala Met Pro His Gln Trp Leu Glu 
225                 230                 235                 240 


Gly Asn Leu Pro Val Ser Ala Lys Cys Thr Val Cys Asp Lys Thr Cys 
                245                 250                 255     


Gly Ser Val Leu Arg Leu Gln Asp Trp Arg Cys Leu Trp Cys Lys Ala 
            260                 265                 270         


Met Val His Thr Ser Cys Lys Glu Ser Leu Leu Thr Lys Cys Pro Leu 
        275                 280                 285             


Gly Leu Cys Lys Val Ser Val Ile Pro Pro Thr Ala Leu Asn Ser Ile 
    290                 295                 300                 


Asp Ser Asp Gly Phe Trp Lys Ala Ser Cys Pro Pro Ser Cys Thr Ser 
305                 310                 315                 320 


Pro Leu Leu Val Phe Val Asn Ser Lys Ser Gly Asp Asn Gln Gly Val 
                325                 330                 335     


Lys Phe Leu Arg Arg Phe Lys Gln Leu Leu Asn Pro Ala Gln Val Phe 
            340                 345                 350         


Asp Leu Met Asn Gly Gly Pro His Leu Gly Leu Arg Leu Phe Gln Lys 
        355                 360                 365             


Phe Asp Thr Phe Arg Ile Leu Val Cys Gly Gly Asp Gly Ser Val Gly 
    370                 375                 380                 


Trp Val Leu Ser Glu Ile Asp Ser Leu Asn Leu His Lys Gln Cys Gln 
385                 390                 395                 400 


Leu Gly Val Leu Pro Leu Gly Thr Gly Asn Asp Leu Ala Arg Val Leu 
                405                 410                 415     


Gly Trp Gly Ser Ala Cys Asp Asp Asp Thr Gln Leu Pro Gln Ile Leu 
            420                 425                 430         


Glu Lys Leu Glu Arg Ala Ser Thr Lys Met Leu Asp Arg Trp Ser Val 
        435                 440                 445             


Met Ala Tyr Glu Ala Lys Leu Pro Arg Gln Ala Ser Ser Ser Thr Val 
    450                 455                 460                 


Thr Glu Asp Phe Ser Glu Asp Ser Glu Val Gln Gln Ile Leu Phe Tyr 
465                 470                 475                 480 


Glu Asp Ser Val Ala Ala His Leu Ser Lys Ile Leu Thr Ser Asp Gln 
                485                 490                 495     


His Ser Val Val Ile Ser Ser Ala Lys Val Leu Cys Glu Thr Val Lys 
            500                 505                 510         


Asp Phe Val Ala Arg Val Gly Lys Ala Tyr Glu Lys Thr Thr Glu Ser 
        515                 520                 525             


Ser Glu Glu Ser Glu Val Met Ala Lys Lys Cys Ser Val Leu Lys Glu 
    530                 535                 540                 


Lys Leu Asp Ser Leu Leu Lys Thr Leu Asp Asp Glu Ser Gln Ala Ser 
545                 550                 555                 560 


Ser Ser Leu Pro Asn Pro Pro Pro Thr Ile Ala Glu Glu Ala Glu Asp 
                565                 570                 575     


Gly Asp Gly Ser Gly Ser Ile Cys Gly Ser Thr Gly Asp Arg Leu Val 
            580                 585                 590         


Ala Ser Ala Cys Pro Ala Arg Pro Gln Ile Phe Arg Pro Arg Glu Gln 
        595                 600                 605             


Leu Met Leu Arg Ala Asn Ser Leu Lys Lys Ala Ile Arg Gln Ile Ile 
    610                 615                 620                 


Glu His Thr Glu Lys Ala Val Asp Glu Gln Asn Ala Gln Thr Gln Glu 
625                 630                 635                 640 


Gln Glu Gly Phe Val Leu Gly Leu Ser Glu Ser Glu Glu Lys Met Asp 
                645                 650                 655     


His Arg Val Cys Pro Pro Leu Ser His Ser Glu Ser Phe Gly Val Pro 
            660                 665                 670         


Lys Gly Arg Ser Gln Arg Lys Val Ser Lys Ser Pro Cys Glu Lys Leu 
        675                 680                 685             


Ile Ser Lys Gly Ser Leu Ser Leu Gly Ser Ser Ala Ser Leu Pro Pro 
    690                 695                 700                 


Gln Pro Gly Ser Arg Asp Gly Leu Pro Ala Leu Asn Thr Lys Ile Leu 
705                 710                 715                 720 


Tyr Pro Asn Val Arg Ala Gly Met Ser Gly Ser Leu Pro Gly Gly Ser 
                725                 730                 735     


Val Ile Ser Arg Leu Leu Ile Asn Ala Asp Pro Phe Asn Ser Glu Pro 
            740                 745                 750         


Glu Thr Leu Glu Tyr Tyr Thr Glu Lys Cys Val Met Asn Asn Tyr Phe 
        755                 760                 765             


Gly Ile Gly Leu Asp Ala Lys Ile Ser Leu Asp Phe Asn Asn Lys Arg 
    770                 775                 780                 


Asp Glu His Pro Glu Lys Cys Arg Ser Arg Thr Lys Asn Met Met Trp 
785                 790                 795                 800 


Tyr Gly Val Leu Gly Thr Lys Glu Leu Leu His Arg Thr Tyr Lys Asn 
                805                 810                 815     


Leu Glu Gln Lys Val Leu Leu Glu Cys Asp Gly Arg Pro Ile Pro Leu 
            820                 825                 830         


Pro Ser Leu Gln Gly Ile Ala Val Leu Asn Ile Pro Ser Tyr Ala Gly 
        835                 840                 845             


Gly Thr Asn Phe Trp Gly Gly Thr Lys Glu Asp Asp Thr Phe Ala Ala 
    850                 855                 860                 


Pro Ser Phe Asp Asp Lys Ile Leu Glu Val Val Ala Val Phe Gly Ser 
865                 870                 875                 880 


Met Gln Met Ala Val Ser Arg Val Ile Arg Leu Gln His His Arg Ile 
                885                 890                 895     


Ala Gln Cys Arg Thr Val Lys Ile Ser Ile Leu Gly Asp Glu Gly Val 
            900                 905                 910         


Pro Val Gln Val Asp Gly Glu Ala Trp Val Gln Pro Pro Gly Tyr Ile 
        915                 920                 925             


Arg Ile Val His Lys Asn Arg Ala Gln Thr Leu Thr Arg Asp Arg Ala 
    930                 935                 940                 


Phe Glu Ser Thr Leu Lys Ser Trp Glu Asp Lys Gln Lys Cys Glu Leu 
945                 950                 955                 960 


Pro Arg Pro Pro Ser Cys Ser Leu His Pro Glu Met Leu Ser Glu Glu 
                965                 970                 975     


Glu Ala Thr Gln Met Asp Gln Phe Gly Gln Ala Ala Gly Val Leu Ile 
            980                 985                 990         


His Ser Ile Arg Glu Ile Ala Gln  Ser His Arg Asp Met  Glu Gln Glu 
        995                 1000                 1005             


Leu Ala  His Ala Val Asn Ala  Ser Ser Lys Ser Met  Asp Arg Val 
    1010                 1015                 1020             


Tyr Gly  Lys Pro Arg Thr Thr  Glu Gly Leu Asn Cys  Ser Phe Val 
    1025                 1030                 1035             


Leu Glu  Met Val Asn Asn Phe  Arg Ala Leu Arg Ser  Glu Thr Glu 
    1040                 1045                 1050             


Leu Leu  Leu Ser Gly Lys Met  Ala Leu Gln Leu Asp  Pro Pro Gln 
    1055                 1060                 1065             


Lys Glu  Gln Leu Gly Ser Ala  Leu Ala Glu Met Asp  Arg Gln Leu 
    1070                 1075                 1080             


Arg Arg  Leu Ala Asp Thr Pro  Trp Leu Cys Gln Ser  Ala Glu Pro 
    1085                 1090                 1095             


Gly Asp  Glu Glu Ser Val Met  Leu Asp Leu Ala Lys  Arg Ser Arg 
    1100                 1105                 1110             


Ser Gly  Lys Phe Arg Leu Val  Thr Lys Phe Lys Lys  Glu Lys Asn 
    1115                 1120                 1125             


Asn Lys  Asn Lys Glu Ala His  Ser Ser Leu Gly Ala  Pro Val His 
    1130                 1135                 1140             


Leu Trp  Gly Thr Glu Glu Val  Ala Ala Trp Leu Glu  His Leu Ser 
    1145                 1150                 1155             


Leu Cys  Glu Tyr Lys Asp Ile  Phe Thr Arg His Asp  Ile Arg Gly 
    1160                 1165                 1170             


Ser Glu  Leu Leu His Leu Glu  Arg Arg Asp Leu Lys  Asp Leu Gly 
    1175                 1180                 1185             


Val Thr  Lys Val Gly His Met  Lys Arg Ile Leu Cys  Gly Ile Lys 
    1190                 1195                 1200             


Glu Leu  Ser Arg Ser Ala Pro  Ala Val Glu Ala 
    1205                 1210                 


<210>  25
<211>  3744
<212>  DNA
<213>  Homosapiens

<400>  25
atgtcacttt ttttaagggt agtatttagt ttcacaatgt ttggggacct gtttgaagag     60

gagtattcca ctgtgtctaa taatcagtat ggaaaaggga agaaattaaa gactaaagct    120

ttggagccac ctgctcctag agaattcacc aatttaagcg gaatcagaaa tcagggtgga    180

acctgttacc tcaattccct tcttcagact cttcatttca cacctgaatt cagagaagct    240

ctattttctc ttggcccaga agagcttggt ttgtttgaag ataaggataa acccgatgca    300

aaggttcgaa tcatcccttt acagttacag cgcttgtttg ctcagcttct gctcttagac    360

caggaagctg catccacagc agacctcact gacagctttg ggtggaccag taatgaggaa    420

atgaggcaac atgatgtgca ggaactgaat cgaatcctct tcagcgcttt ggaaacttct    480

ttagttggga cctccggtca tgacctcatc tatcgtctgt accatggaac cattgttaac    540

cagattgttt gtaaagaatg taagaacgtt agcgagaggc aggaagactt cttagatcta    600

acagtagcag tcaaaaatgt atccggtttg gaagatgctc tctggaacat gtatgtagaa    660

gaggaagttt ttgattgtga caacttgtac cactgtggaa cttgtgacag gctggttaaa    720

gcagcaaagt cggccaaatt acgtaagctg cctccttttc ttactgtttc attactaaga    780

tttaattttg attttgtgaa atgcgaacgc tacaaggaaa ctagctgtta tacattccct    840

ctccggatta atctcaagcc cttttgtgaa cagagtgaat tggatgactt agaatatata    900

tatgacctct tctcagttat tatacacaaa ggtggctgct acggaggcca ttaccatgta    960

tatattaaag atgttgatca tttgggaaac tggcagtttc aagaggaaaa aagtaaacca   1020

gatgtgaatc tgaaagatct ccagagtgaa gaagagattg atcatccact gatgattcta   1080

aaagcaatct tattagagga gaataatcta attcctgttg atcagctggg ccagaaactt   1140

ttgaaaaaga taggaatatc ttggaacaag aagtacagaa aacagcatgg accattgcgg   1200

aagttcttac agctccattc tcagatattt ctactcagtt cagatgaaag tacagttcgt   1260

ctcttgaaga atagttctct ccaggctgag tctgatttcc aaaggaatga ccagcaaatt   1320

ttcaagatgc ttcctccaga atccccaggt ttaaacaata gcatctcctg tccccactgg   1380

tttgatataa atgattctaa agtccagcca atcagggaaa aggatattga acagcaattt   1440

cagggtaaag aaagtgccta catgttgttt tatcggaaat cccagttgca gagaccccct   1500

gaagctcgag ctaatccaag atatggggtt ccatgtcatt tactgaatga aatggatgca   1560

gctaacattg aactgcaaac caaaagggca gaatgtgatt ctgcaaacaa tacttttgaa   1620

ttgcatcttc acctgggccc tcagtatcat ttcttcaatg gggctctgca cccagtagtc   1680

tctcaaacag aaagcgtgtg ggatttgacc tttgataaaa gaaaaacttt aggagatctc   1740

cggcagtcaa tatttcagct gttagaattt tgggaaggag acatggttct tagtgttgca   1800

aagcttgtac cagcaggact tcacatttac cagtcacttg gcggggatga actgacactg   1860

tgtgaaactg aaattgctga tggggaagac atctttgtgt ggaatggggt ggaggttggt   1920

ggagtccaca ttcaaactgg tattgactgc gaacctctac ttttaaatgt tcttcatcta   1980

gacacaagca gtgatggaga aaagtgttgt caggtgatag aatctccaca tgtctttcca   2040

gctaatgcag aagtgggcac tgtcctcaca gccttagcaa tcccagcagg tgtcatcttc   2100

atcaacagtg ctggatgtcc aggtggggag ggttggacgg ccatccccaa ggaagacatg   2160

aggaagacgt tcagggagca agggctcaga aatggaagct caattttaat tcaggattct   2220

catgatgata acagcttgtt gaccaaggaa gagaaatggg tcactagtat gaatgagatt   2280

gactggctcc acgttaaaaa tttatgccag ttagaatctg aagagaagca agttaaaata   2340

tcagcaactg ttaacacaat ggtgtttgat attcgaatta aagccataaa ggaattaaaa   2400

ttaatgaagg aactagctga caacagctgt ttgagaccta ttgatagaaa tgggaagctt   2460

ctttgtccag tgccggacag ctatactttg aaggaagcag aattgaagat gggaagttca   2520

ttgggactgt gtcttggaaa agcaccaagt tcgtctcagt tgttcctgtt ttttgcaatg   2580

gggagtgacg ttcaacctgg gacagaaatg gaaatcgtag tagaagaaac aatatctgtg   2640

agagattgtt taaagttaat gctgaagaaa tctggcctac aaggagatgc ctggcattta   2700

cgaaaaatgg attggtgcta tgaagctgga gagcctttat gtgaagaaga tgcaacactg   2760

aaagaacttc tgatatgttc tggagatact ttgcttttaa ttgaaggaca acttcctcct   2820

ctgggtttcc tgaaggtgcc catctggtgg taccagcttc agggtccctc aggacactgg   2880

gagagtcatc aggaccagac caactgtact tcgtcttggg gcagagtttg gagagccact   2940

tccagccaag gtgcttctgg gaacgagcct gcgcaagttt ctctcctcta cttgggagac   3000

atagagatct cagaagatgc cacgctggcg gagctgaagt ctcaggccat gaccttgcct   3060

cctttcctgg agttcggtgt cccgtcccca gcccacctca gagcctggac ggtggagagg   3120

aagcgcccag gcaggctttt acgaactgac cggcagccac tcagggaata taaactagga   3180

cggagaattg agatctgctt agagcccctt cagaaaggcg aaaacttggg cccccaggac   3240

gtgctgctga ggacacaggt gcgcatccct ggtgagagga cctatgcccc tgccctggac   3300

ctggtgtgga acgcggccca gggtgggact gccggctccc tgaggcagag agttgccgat   3360

ttctatcgtc ttcccgtgga gaagattgaa attgccaaat actttcccga aaagttcgag   3420

tggcttccga tatctagctg gaaccaacaa ataaccaaga ggaaaaagaa aaaaaaacaa   3480

gattatttgc aaggggcacc gtattacttg aaagacggag atactattgg tgttaagaat   3540

ctcctgattg acgacgatga tgatttcagt acaatcagag atgacactgg aaaagaaaag   3600

cagaaacaac gggccctggg gagaaggaaa agccaagaag ccctccatga gcagagcagc   3660

tacatcctct ccagtgcaga gacgcctgcc cggccccgag ccccggaaac ttctctctcc   3720

atccacgtgg ggagcttcag ataa                                          3744


<210>  26
<211>  1247
<212>  PRT
<213>  Homosapiens

<400>  26

Met Ser Leu Phe Leu Arg Val Val Phe Ser Phe Thr Met Phe Gly Asp 
1               5                   10                  15      


Leu Phe Glu Glu Glu Tyr Ser Thr Val Ser Asn Asn Gln Tyr Gly Lys 
            20                  25                  30          


Gly Lys Lys Leu Lys Thr Lys Ala Leu Glu Pro Pro Ala Pro Arg Glu 
        35                  40                  45              


Phe Thr Asn Leu Ser Gly Ile Arg Asn Gln Gly Gly Thr Cys Tyr Leu 
    50                  55                  60                  


Asn Ser Leu Leu Gln Thr Leu His Phe Thr Pro Glu Phe Arg Glu Ala 
65                  70                  75                  80  


Leu Phe Ser Leu Gly Pro Glu Glu Leu Gly Leu Phe Glu Asp Lys Asp 
                85                  90                  95      


Lys Pro Asp Ala Lys Val Arg Ile Ile Pro Leu Gln Leu Gln Arg Leu 
            100                 105                 110         


Phe Ala Gln Leu Leu Leu Leu Asp Gln Glu Ala Ala Ser Thr Ala Asp 
        115                 120                 125             


Leu Thr Asp Ser Phe Gly Trp Thr Ser Asn Glu Glu Met Arg Gln His 
    130                 135                 140                 


Asp Val Gln Glu Leu Asn Arg Ile Leu Phe Ser Ala Leu Glu Thr Ser 
145                 150                 155                 160 


Leu Val Gly Thr Ser Gly His Asp Leu Ile Tyr Arg Leu Tyr His Gly 
                165                 170                 175     


Thr Ile Val Asn Gln Ile Val Cys Lys Glu Cys Lys Asn Val Ser Glu 
            180                 185                 190         


Arg Gln Glu Asp Phe Leu Asp Leu Thr Val Ala Val Lys Asn Val Ser 
        195                 200                 205             


Gly Leu Glu Asp Ala Leu Trp Asn Met Tyr Val Glu Glu Glu Val Phe 
    210                 215                 220                 


Asp Cys Asp Asn Leu Tyr His Cys Gly Thr Cys Asp Arg Leu Val Lys 
225                 230                 235                 240 


Ala Ala Lys Ser Ala Lys Leu Arg Lys Leu Pro Pro Phe Leu Thr Val 
                245                 250                 255     


Ser Leu Leu Arg Phe Asn Phe Asp Phe Val Lys Cys Glu Arg Tyr Lys 
            260                 265                 270         


Glu Thr Ser Cys Tyr Thr Phe Pro Leu Arg Ile Asn Leu Lys Pro Phe 
        275                 280                 285             


Cys Glu Gln Ser Glu Leu Asp Asp Leu Glu Tyr Ile Tyr Asp Leu Phe 
    290                 295                 300                 


Ser Val Ile Ile His Lys Gly Gly Cys Tyr Gly Gly His Tyr His Val 
305                 310                 315                 320 


Tyr Ile Lys Asp Val Asp His Leu Gly Asn Trp Gln Phe Gln Glu Glu 
                325                 330                 335     


Lys Ser Lys Pro Asp Val Asn Leu Lys Asp Leu Gln Ser Glu Glu Glu 
            340                 345                 350         


Ile Asp His Pro Leu Met Ile Leu Lys Ala Ile Leu Leu Glu Glu Asn 
        355                 360                 365             


Asn Leu Ile Pro Val Asp Gln Leu Gly Gln Lys Leu Leu Lys Lys Ile 
    370                 375                 380                 


Gly Ile Ser Trp Asn Lys Lys Tyr Arg Lys Gln His Gly Pro Leu Arg 
385                 390                 395                 400 


Lys Phe Leu Gln Leu His Ser Gln Ile Phe Leu Leu Ser Ser Asp Glu 
                405                 410                 415     


Ser Thr Val Arg Leu Leu Lys Asn Ser Ser Leu Gln Ala Glu Ser Asp 
            420                 425                 430         


Phe Gln Arg Asn Asp Gln Gln Ile Phe Lys Met Leu Pro Pro Glu Ser 
        435                 440                 445             


Pro Gly Leu Asn Asn Ser Ile Ser Cys Pro His Trp Phe Asp Ile Asn 
    450                 455                 460                 


Asp Ser Lys Val Gln Pro Ile Arg Glu Lys Asp Ile Glu Gln Gln Phe 
465                 470                 475                 480 


Gln Gly Lys Glu Ser Ala Tyr Met Leu Phe Tyr Arg Lys Ser Gln Leu 
                485                 490                 495     


Gln Arg Pro Pro Glu Ala Arg Ala Asn Pro Arg Tyr Gly Val Pro Cys 
            500                 505                 510         


His Leu Leu Asn Glu Met Asp Ala Ala Asn Ile Glu Leu Gln Thr Lys 
        515                 520                 525             


Arg Ala Glu Cys Asp Ser Ala Asn Asn Thr Phe Glu Leu His Leu His 
    530                 535                 540                 


Leu Gly Pro Gln Tyr His Phe Phe Asn Gly Ala Leu His Pro Val Val 
545                 550                 555                 560 


Ser Gln Thr Glu Ser Val Trp Asp Leu Thr Phe Asp Lys Arg Lys Thr 
                565                 570                 575     


Leu Gly Asp Leu Arg Gln Ser Ile Phe Gln Leu Leu Glu Phe Trp Glu 
            580                 585                 590         


Gly Asp Met Val Leu Ser Val Ala Lys Leu Val Pro Ala Gly Leu His 
        595                 600                 605             


Ile Tyr Gln Ser Leu Gly Gly Asp Glu Leu Thr Leu Cys Glu Thr Glu 
    610                 615                 620                 


Ile Ala Asp Gly Glu Asp Ile Phe Val Trp Asn Gly Val Glu Val Gly 
625                 630                 635                 640 


Gly Val His Ile Gln Thr Gly Ile Asp Cys Glu Pro Leu Leu Leu Asn 
                645                 650                 655     


Val Leu His Leu Asp Thr Ser Ser Asp Gly Glu Lys Cys Cys Gln Val 
            660                 665                 670         


Ile Glu Ser Pro His Val Phe Pro Ala Asn Ala Glu Val Gly Thr Val 
        675                 680                 685             


Leu Thr Ala Leu Ala Ile Pro Ala Gly Val Ile Phe Ile Asn Ser Ala 
    690                 695                 700                 


Gly Cys Pro Gly Gly Glu Gly Trp Thr Ala Ile Pro Lys Glu Asp Met 
705                 710                 715                 720 


Arg Lys Thr Phe Arg Glu Gln Gly Leu Arg Asn Gly Ser Ser Ile Leu 
                725                 730                 735     


Ile Gln Asp Ser His Asp Asp Asn Ser Leu Leu Thr Lys Glu Glu Lys 
            740                 745                 750         


Trp Val Thr Ser Met Asn Glu Ile Asp Trp Leu His Val Lys Asn Leu 
        755                 760                 765             


Cys Gln Leu Glu Ser Glu Glu Lys Gln Val Lys Ile Ser Ala Thr Val 
    770                 775                 780                 


Asn Thr Met Val Phe Asp Ile Arg Ile Lys Ala Ile Lys Glu Leu Lys 
785                 790                 795                 800 


Leu Met Lys Glu Leu Ala Asp Asn Ser Cys Leu Arg Pro Ile Asp Arg 
                805                 810                 815     


Asn Gly Lys Leu Leu Cys Pro Val Pro Asp Ser Tyr Thr Leu Lys Glu 
            820                 825                 830         


Ala Glu Leu Lys Met Gly Ser Ser Leu Gly Leu Cys Leu Gly Lys Ala 
        835                 840                 845             


Pro Ser Ser Ser Gln Leu Phe Leu Phe Phe Ala Met Gly Ser Asp Val 
    850                 855                 860                 


Gln Pro Gly Thr Glu Met Glu Ile Val Val Glu Glu Thr Ile Ser Val 
865                 870                 875                 880 


Arg Asp Cys Leu Lys Leu Met Leu Lys Lys Ser Gly Leu Gln Gly Asp 
                885                 890                 895     


Ala Trp His Leu Arg Lys Met Asp Trp Cys Tyr Glu Ala Gly Glu Pro 
            900                 905                 910         


Leu Cys Glu Glu Asp Ala Thr Leu Lys Glu Leu Leu Ile Cys Ser Gly 
        915                 920                 925             


Asp Thr Leu Leu Leu Ile Glu Gly Gln Leu Pro Pro Leu Gly Phe Leu 
    930                 935                 940                 


Lys Val Pro Ile Trp Trp Tyr Gln Leu Gln Gly Pro Ser Gly His Trp 
945                 950                 955                 960 


Glu Ser His Gln Asp Gln Thr Asn Cys Thr Ser Ser Trp Gly Arg Val 
                965                 970                 975     


Trp Arg Ala Thr Ser Ser Gln Gly Ala Ser Gly Asn Glu Pro Ala Gln 
            980                 985                 990         


Val Ser Leu Leu Tyr Leu Gly Asp  Ile Glu Ile Ser Glu  Asp Ala Thr 
        995                 1000                 1005             


Leu Ala  Glu Leu Lys Ser Gln  Ala Met Thr Leu Pro  Pro Phe Leu 
    1010                 1015                 1020             


Glu Phe  Gly Val Pro Ser Pro  Ala His Leu Arg Ala  Trp Thr Val 
    1025                 1030                 1035             


Glu Arg  Lys Arg Pro Gly Arg  Leu Leu Arg Thr Asp  Arg Gln Pro 
    1040                 1045                 1050             


Leu Arg  Glu Tyr Lys Leu Gly  Arg Arg Ile Glu Ile  Cys Leu Glu 
    1055                 1060                 1065             


Pro Leu  Gln Lys Gly Glu Asn  Leu Gly Pro Gln Asp  Val Leu Leu 
    1070                 1075                 1080             


Arg Thr  Gln Val Arg Ile Pro  Gly Glu Arg Thr Tyr  Ala Pro Ala 
    1085                 1090                 1095             


Leu Asp  Leu Val Trp Asn Ala  Ala Gln Gly Gly Thr  Ala Gly Ser 
    1100                 1105                 1110             


Leu Arg  Gln Arg Val Ala Asp  Phe Tyr Arg Leu Pro  Val Glu Lys 
    1115                 1120                 1125             


Ile Glu  Ile Ala Lys Tyr Phe  Pro Glu Lys Phe Glu  Trp Leu Pro 
    1130                 1135                 1140             


Ile Ser  Ser Trp Asn Gln Gln  Ile Thr Lys Arg Lys  Lys Lys Lys 
    1145                 1150                 1155             


Lys Gln  Asp Tyr Leu Gln Gly  Ala Pro Tyr Tyr Leu  Lys Asp Gly 
    1160                 1165                 1170             


Asp Thr  Ile Gly Val Lys Asn  Leu Leu Ile Asp Asp  Asp Asp Asp 
    1175                 1180                 1185             


Phe Ser  Thr Ile Arg Asp Asp  Thr Gly Lys Glu Lys  Gln Lys Gln 
    1190                 1195                 1200             


Arg Ala  Leu Gly Arg Arg Lys  Ser Gln Glu Ala Leu  His Glu Gln 
    1205                 1210                 1215             


Ser Ser  Tyr Ile Leu Ser Ser  Ala Glu Thr Pro Ala  Arg Pro Arg 
    1220                 1225                 1230             


Ala Pro  Glu Thr Ser Leu Ser  Ile His Val Gly Ser  Phe Arg 
    1235                 1240                 1245         


<210>  27
<211>  2396
<212>  DNA
<213>  Homosapiens

<400>  27
cttccgccta ctgtatcata gcagcttaga atcccagctg ctggctcggg ctgcagttct     60

ctcatggctc gcacagggtg gaccagcccc attcccctat gtgtttctct gctgctgacc    120

tgtggctttg ctgaggcagg gaagctgctg gtagtgccca tggatgggag tcactggttc    180

accatgcagt cggtggtgga gaaacttatc ctcagggggc atgaggtggt tgtagtcatg    240

ccagaggtga gttggcaact gggaaaatca ctgaattgca cagtgaagac ttactcaacc    300

tcatacactc tggaggatct ggaccgggaa ttcatggatt tcgccgatgc tcaatggaaa    360

gcacaagtac gaagtttgtt ttctctattt ctgagttcat ccaatggttt ttttaactta    420

tttttttcgc attgcaggag tttgtttaat gaccgaaaat tagtagaata cttaaaggag    480

agttcttttg atgcggtgtt tcttgatcct tttgatgcct gtggcttaat tgttgccaaa    540

tatttctccc tcccctctgt ggtcttcgcc aggggaatag cttgccacta tcttgaagaa    600

ggtgcacagt gccctgctcc tctttcctat gtccccagaa ttctcttagg gttctcagat    660

gccatgactt tcaaggagag agtacggaac cacatcatgc acttggagga acatttattt    720

tgccagtatt tttccaaaaa tgccctagaa atagcctctg aaattctcca aacacctgtc    780

acagcatatg atctctacag ccacacatca atttggttgt tgcgaacaga ctttgttttg    840

gactatccca aacccgtgat gcccaatatg atcttcattg gtggtatcaa ctgccatcag    900

ggaaagccat tgcctatgga atttgaagcc tacattaatg cttctggaga acatggaatt    960

gtggttttct ctttgggatc aatggtctca gaaattccag agaagaaagc tatggcaatt   1020

gctgatgctt tgggcaaaat ccctcagaca gtcctgtggc ggtacactgg aacccgacca   1080

tcgaatcttg cgaacaacac gatacttgtt aagtggctac cccaaaacga tctgcttggt   1140

cacccgatga cccgtgcctt tatcacccat gctggttccc atggtgttta tgaaagcata   1200

tgcaatggcg ttcccatggt gatgatgccc ttgtttggtg atcagatgga caatgcaaag   1260

cgcatggaga ctaagggagc tggagtgacc ctgaatgttc tggaaatgac ttctgaagat   1320

ttagaaaatg ctctaaaagc agtcatcaat gacaaaagtt acaaggagaa catcatgcgc   1380

ctctccagcc ttcacaagga ccgcccggtg gagccgctgg acctggccgt gttctgggtg   1440

gagtttgtga tgaggcacaa gggcgcgcca cacctgcgcc ccgcagccca cgacctcacc   1500

tggtaccagt accattcctt ggacgtgatt ggtttcctct tggccgtcgt gctgacagtg   1560

gccttcatca cctttaaatg ttgtgcttat ggctaccgga aatgcttggg gaaaaaaggg   1620

cgagttaaga aagcccacaa atccaagacc cattgagaag tgggtgggaa ataaggtaaa   1680

attttgaacc attccctagt catttccaaa cttgaaaaca gaatcagtgt taaattcatt   1740

ttattcttat taaggaaata ctttgcataa attaatcagc cccagagtgc tttaaaaaat   1800

tctcttaaat aaaaataata gactcgctag tcagtaaaga tatttgaata tgtatcgtgc   1860

cccctctggt gtctttgatc aggatgacat gtgccatttt tcagaggacg tgcagacagg   1920

ctggcattct agattacttt tcttactctg aaacatggcc tgtttgggag tgcgggattc   1980

aaaggtggtc ccacggctgc ccctactgca aatggcagtt ttaatcttat cttttggctt   2040

ctgcagatgg ttgcaattga tccttaacca ataatggtca gtcctcatct ctgtcgtgct   2100

tcataggtgc caccttgtgt gtttaaagaa gggaagcttt gtacctttag agtgtaggtg   2160

aaatgaatga atggcttgga gtgcactgag aacagcatat gatttcttgc tttggggaaa   2220

aagaatgatg ctatgaaatt ggtgggtggt gtatttgaga agataatcat tgcttatgtc   2280

aaatggagct gaatttgata aaaacccaaa atacagctat gaagtgctgg gcaagtttac   2340

tttttttctg atgtttccta caactaaaaa taaattaata aatttatata aattct       2396


<210>  28
<211>  530
<212>  PRT
<213>  Homosapiens

<400>  28

Met Ala Arg Thr Gly Trp Thr Ser Pro Ile Pro Leu Cys Val Ser Leu 
1               5                   10                  15      


Leu Leu Thr Cys Gly Phe Ala Glu Ala Gly Lys Leu Leu Val Val Pro 
            20                  25                  30          


Met Asp Gly Ser His Trp Phe Thr Met Gln Ser Val Val Glu Lys Leu 
        35                  40                  45              


Ile Leu Arg Gly His Glu Val Val Val Val Met Pro Glu Val Ser Trp 
    50                  55                  60                  


Gln Leu Gly Lys Ser Leu Asn Cys Thr Val Lys Thr Tyr Ser Thr Ser 
65                  70                  75                  80  


Tyr Thr Leu Glu Asp Leu Asp Arg Glu Phe Met Asp Phe Ala Asp Ala 
                85                  90                  95      


Gln Trp Lys Ala Gln Val Arg Ser Leu Phe Ser Leu Phe Leu Ser Ser 
            100                 105                 110         


Ser Asn Gly Phe Phe Asn Leu Phe Phe Ser His Cys Arg Ser Leu Phe 
        115                 120                 125             


Asn Asp Arg Lys Leu Val Glu Tyr Leu Lys Glu Ser Ser Phe Asp Ala 
    130                 135                 140                 


Val Phe Leu Asp Pro Phe Asp Ala Cys Gly Leu Ile Val Ala Lys Tyr 
145                 150                 155                 160 


Phe Ser Leu Pro Ser Val Val Phe Ala Arg Gly Ile Ala Cys His Tyr 
                165                 170                 175     


Leu Glu Glu Gly Ala Gln Cys Pro Ala Pro Leu Ser Tyr Val Pro Arg 
            180                 185                 190         


Ile Leu Leu Gly Phe Ser Asp Ala Met Thr Phe Lys Glu Arg Val Arg 
        195                 200                 205             


Asn His Ile Met His Leu Glu Glu His Leu Phe Cys Gln Tyr Phe Ser 
    210                 215                 220                 


Lys Asn Ala Leu Glu Ile Ala Ser Glu Ile Leu Gln Thr Pro Val Thr 
225                 230                 235                 240 


Ala Tyr Asp Leu Tyr Ser His Thr Ser Ile Trp Leu Leu Arg Thr Asp 
                245                 250                 255     


Phe Val Leu Asp Tyr Pro Lys Pro Val Met Pro Asn Met Ile Phe Ile 
            260                 265                 270         


Gly Gly Ile Asn Cys His Gln Gly Lys Pro Leu Pro Met Glu Phe Glu 
        275                 280                 285             


Ala Tyr Ile Asn Ala Ser Gly Glu His Gly Ile Val Val Phe Ser Leu 
    290                 295                 300                 


Gly Ser Met Val Ser Glu Ile Pro Glu Lys Lys Ala Met Ala Ile Ala 
305                 310                 315                 320 


Asp Ala Leu Gly Lys Ile Pro Gln Thr Val Leu Trp Arg Tyr Thr Gly 
                325                 330                 335     


Thr Arg Pro Ser Asn Leu Ala Asn Asn Thr Ile Leu Val Lys Trp Leu 
            340                 345                 350         


Pro Gln Asn Asp Leu Leu Gly His Pro Met Thr Arg Ala Phe Ile Thr 
        355                 360                 365             


His Ala Gly Ser His Gly Val Tyr Glu Ser Ile Cys Asn Gly Val Pro 
    370                 375                 380                 


Met Val Met Met Pro Leu Phe Gly Asp Gln Met Asp Asn Ala Lys Arg 
385                 390                 395                 400 


Met Glu Thr Lys Gly Ala Gly Val Thr Leu Asn Val Leu Glu Met Thr 
                405                 410                 415     


Ser Glu Asp Leu Glu Asn Ala Leu Lys Ala Val Ile Asn Asp Lys Ser 
            420                 425                 430         


Tyr Lys Glu Asn Ile Met Arg Leu Ser Ser Leu His Lys Asp Arg Pro 
        435                 440                 445             


Val Glu Pro Leu Asp Leu Ala Val Phe Trp Val Glu Phe Val Met Arg 
    450                 455                 460                 


His Lys Gly Ala Pro His Leu Arg Pro Ala Ala His Asp Leu Thr Trp 
465                 470                 475                 480 


Tyr Gln Tyr His Ser Leu Asp Val Ile Gly Phe Leu Leu Ala Val Val 
                485                 490                 495     


Leu Thr Val Ala Phe Ile Thr Phe Lys Cys Cys Ala Tyr Gly Tyr Arg 
            500                 505                 510         


Lys Cys Leu Gly Lys Lys Gly Arg Val Lys Lys Ala His Lys Ser Lys 
        515                 520                 525             


Thr His 
    530 


<210>  29
<211>  2399
<212>  DNA
<213>  Homosapiens

<400>  29
atagcagctt agaatcccag ctgctggctc gggctgcagt tctctcatgg ctcgcgcagg     60

gtggaccagc cccgttcctt tatgtgtgtg tctactgctg acctgtggct ttgccgaggc    120

agggaagctg ctggtagtgc ccatggatgg gagtcactgg ttcaccatgc agtcggtggt    180

ggagaaactt atcctcaggg ggcatgaggt ggttgtagtc atgccagagg tgagttggca    240

actggaaaga tcactgaatt gcacagtgaa gacttactca acctcgtaca ctctggaaga    300

tcagaaccgg gaattcatgg ttttcgccca tgctcaatgg aaagcacagg cacaaagtat    360

attttctcta ttaatgagtt catccagtgg ttttcttgac ttattttttt cgcattgcag    420

gagtttgttt aatgaccgaa aattagtaga atacttaaag gagagttctt ttgatgcagt    480

gtttctggat ccttttgata cctgtggctt aattgttgct aaatatttct ccctcccctc    540

tgtggtcttc accaggggaa tattttgcca ccatcttgaa gaaggtgcac agtgccctgc    600

tcctctttcc tatgtcccca atgatctctt agggttctca gatgccatga ctttcaagga    660

gagagtatgg aaccacatcg tgcacttgga ggaccattta ttttgccagt atctttttag    720

aaatgcccta gaaatagcct ctgaaattct ccaaacccct gtcacggcat atgatctcta    780

cagtcacaca tcaatttggt tgttgcgaac ggactttgtt ttggactatc ccaaacccgt    840

gatgcccaac atgatcttca ttggtggtat caactgtcat cagggaaagc cattgcctat    900

ggaatttgaa gcctacatta atgcttctgg agaacatgga attgtggttt tctctttggg    960

atcaatggtc tcagaaattc cagagaagaa agctatggca attgctgatg ctttgggcaa   1020

aatccctcag acagtcctgt ggcggtacac tggaacccga ccatcgaatc ttgcgaacaa   1080

cacgatactt gttaagtggc taccccaaaa cgatctgctt ggtcacccga tgacccgtgc   1140

ctttatcacc catgctggtt cccatggtgt ttatgaaagc atatgcaatg gcgttcccat   1200

ggtgatgatg cccttgtttg gtgatcagat ggacaatgca aagcgcatgg agactaaggg   1260

agctggagtg accctgaatg ttctggaaat gacttctgaa gatttagaaa atgctctaaa   1320

agcagtcatc aatgacaaaa gttacaagga gaacatcatg cgcctctcca gccttcacaa   1380

ggaccgcccg gtggagccgc tggacctggc cgtgttctgg gtggagtttg tgatgaggca   1440

caagggcgcg ccacacctgc gccccgcagc ccacgacctc acctggtacc agtaccattc   1500

cttggacgtg attggtttcc tcttggccgt cgtgctgaca gtggccttca tcacctttaa   1560

atgttgtgct tatggctacc ggaaatgctt ggggaaaaaa gggcgagtta agaaagccca   1620

caaatccaag acccattgag aagtgggtgg gaaataaggt aaaattttga accattccct   1680

agtcatttcc aaacttgaaa acagaatcag tgttaaattc attttattct tattaaggaa   1740

atactttgca taaattaatc agccccagag tgctttaaaa aattctctta aataaaaata   1800

atagactcgc tagtcagtaa agatatttga atatgtatcg tgccccctct ggtgtctttg   1860

atcaggatga catgtgccat ttttcagagg acgtgcagac aggctggcat tctagattac   1920

ttttcttact ctgaaacatg gcctgtttgg gagtgcggga ttcaaaggtg gtcccacggc   1980

tgcccctact gcaaatggca gttttaatct tatcttttgg cttctgcaga tggttgcaat   2040

tgatccttaa ccaataatgg tcagtcctca tctctgtcgt gcttcatagg tgccaccttg   2100

tgtgtttaaa gaagggaagc tttgtacctt tagagtgtag gtgaaatgaa tgaatggctt   2160

ggagtgcact gagaacagca tatgatttct tgctttgggg aaaaagaatg atgctatgaa   2220

attggtgggt ggtgtatttg agaagataat cattgcttat gtcaaatgga gctgaatttg   2280

ataaaaaccc aaaatacagc tatgaagtgc tgggcaagtt tacttttttt ctgatgtttc   2340

ctacaactaa aaataaatta ataaatttat ataaattcta tttaaaaaaa aaaaaaaaa    2399


<210>  30
<211>  530
<212>  PRT
<213>  Homosapiens

<400>  30

Met Ala Arg Ala Gly Trp Thr Ser Pro Val Pro Leu Cys Val Cys Leu 
1               5                   10                  15      


Leu Leu Thr Cys Gly Phe Ala Glu Ala Gly Lys Leu Leu Val Val Pro 
            20                  25                  30          


Met Asp Gly Ser His Trp Phe Thr Met Gln Ser Val Val Glu Lys Leu 
        35                  40                  45              


Ile Leu Arg Gly His Glu Val Val Val Val Met Pro Glu Val Ser Trp 
    50                  55                  60                  


Gln Leu Glu Arg Ser Leu Asn Cys Thr Val Lys Thr Tyr Ser Thr Ser 
65                  70                  75                  80  


Tyr Thr Leu Glu Asp Gln Asn Arg Glu Phe Met Val Phe Ala His Ala 
                85                  90                  95      


Gln Trp Lys Ala Gln Ala Gln Ser Ile Phe Ser Leu Leu Met Ser Ser 
            100                 105                 110         


Ser Ser Gly Phe Leu Asp Leu Phe Phe Ser His Cys Arg Ser Leu Phe 
        115                 120                 125             


Asn Asp Arg Lys Leu Val Glu Tyr Leu Lys Glu Ser Ser Phe Asp Ala 
    130                 135                 140                 


Val Phe Leu Asp Pro Phe Asp Thr Cys Gly Leu Ile Val Ala Lys Tyr 
145                 150                 155                 160 


Phe Ser Leu Pro Ser Val Val Phe Thr Arg Gly Ile Phe Cys His His 
                165                 170                 175     


Leu Glu Glu Gly Ala Gln Cys Pro Ala Pro Leu Ser Tyr Val Pro Asn 
            180                 185                 190         


Asp Leu Leu Gly Phe Ser Asp Ala Met Thr Phe Lys Glu Arg Val Trp 
        195                 200                 205             


Asn His Ile Val His Leu Glu Asp His Leu Phe Cys Gln Tyr Leu Phe 
    210                 215                 220                 


Arg Asn Ala Leu Glu Ile Ala Ser Glu Ile Leu Gln Thr Pro Val Thr 
225                 230                 235                 240 


Ala Tyr Asp Leu Tyr Ser His Thr Ser Ile Trp Leu Leu Arg Thr Asp 
                245                 250                 255     


Phe Val Leu Asp Tyr Pro Lys Pro Val Met Pro Asn Met Ile Phe Ile 
            260                 265                 270         


Gly Gly Ile Asn Cys His Gln Gly Lys Pro Leu Pro Met Glu Phe Glu 
        275                 280                 285             


Ala Tyr Ile Asn Ala Ser Gly Glu His Gly Ile Val Val Phe Ser Leu 
    290                 295                 300                 


Gly Ser Met Val Ser Glu Ile Pro Glu Lys Lys Ala Met Ala Ile Ala 
305                 310                 315                 320 


Asp Ala Leu Gly Lys Ile Pro Gln Thr Val Leu Trp Arg Tyr Thr Gly 
                325                 330                 335     


Thr Arg Pro Ser Asn Leu Ala Asn Asn Thr Ile Leu Val Lys Trp Leu 
            340                 345                 350         


Pro Gln Asn Asp Leu Leu Gly His Pro Met Thr Arg Ala Phe Ile Thr 
        355                 360                 365             


His Ala Gly Ser His Gly Val Tyr Glu Ser Ile Cys Asn Gly Val Pro 
    370                 375                 380                 


Met Val Met Met Pro Leu Phe Gly Asp Gln Met Asp Asn Ala Lys Arg 
385                 390                 395                 400 


Met Glu Thr Lys Gly Ala Gly Val Thr Leu Asn Val Leu Glu Met Thr 
                405                 410                 415     


Ser Glu Asp Leu Glu Asn Ala Leu Lys Ala Val Ile Asn Asp Lys Ser 
            420                 425                 430         


Tyr Lys Glu Asn Ile Met Arg Leu Ser Ser Leu His Lys Asp Arg Pro 
        435                 440                 445             


Val Glu Pro Leu Asp Leu Ala Val Phe Trp Val Glu Phe Val Met Arg 
    450                 455                 460                 


His Lys Gly Ala Pro His Leu Arg Pro Ala Ala His Asp Leu Thr Trp 
465                 470                 475                 480 


Tyr Gln Tyr His Ser Leu Asp Val Ile Gly Phe Leu Leu Ala Val Val 
                485                 490                 495     


Leu Thr Val Ala Phe Ile Thr Phe Lys Cys Cys Ala Tyr Gly Tyr Arg 
            500                 505                 510         


Lys Cys Leu Gly Lys Lys Gly Arg Val Lys Lys Ala His Lys Ser Lys 
        515                 520                 525             


Thr His 
    530 


<210>  31
<211>  2395
<212>  DNA
<213>  Homosapiens

<400>  31
agattcccag ctgcttgctc tcagctgcag ttctctgatg gcttgcacag ggtggaccag     60

cccccttcct ctatgtgtgt gtctgctgct gacctgtggc tttgccgagg cagggaagct    120

actggtagtg cccatggatg ggagccactg gttcaccatg aggtcggtgg tggagaaact    180

cattctcagg gggcatgagg tggttgtagt catgccagag gtgagttggc aactgggaag    240

atcactgaat tgcacagtga agacttattc aacttcatat accctggagg atctggaccg    300

ggagttcaag gcttttgccc atgctcaatg gaaagcacaa gtacgaagta tatattctct    360

attaatgggt tcatacaatg acatttttga cttatttttt tcaaattgca ggagtttgtt    420

taaagacaaa aaattagtag aatacttaaa ggagagttct tttgatgcag tgtttctcga    480

tccttttgat aactgtggct taattgttgc caaatatttc tccctcccct ccgtggtctt    540

cgccagggga atactttgcc actatcttga agaaggtgca cagtgccctg ctcctctttc    600

ctatgtcccc agaattctct tagggttctc agatgccatg actttcaagg agagagtacg    660

gaaccacatc atgcacttgg aggaacattt attatgccac cgttttttca aaaatgccct    720

agaaatagcc tctgaaattc tccaaacacc tgttacggag tatgatctct acagccacac    780

atcaatttgg ttgttgcgaa cggactttgt tttggactat cccaaacccg tgatgcccaa    840

catgatcttc attggtggta tcaactgcca tcagggaaag ccgttgccta tggaatttga    900

agcctacatt aatgcttctg gagaacatgg aattgtggtt ttctctttgg gatcaatggt    960

ctcagaaatt ccagagaaga aagctatggc aattgctgat gctttgggca aaatccctca   1020

gacagtcctg tggcggtaca ctggaacccg accatcgaat cttgcgaaca acacgatact   1080

tgttaagtgg ctaccccaaa acgatctgct tggtcacccg atgacccgtg cctttatcac   1140

ccatgctggt tcccatggtg tttatgaaag catatgcaat ggcgttccca tggtgatgat   1200

gcccttgttt ggtgatcaga tggacaatgc aaagcgcatg gagactaagg gagctggagt   1260

gaccctgaat gttctggaaa tgacttctga agatttagaa aatgctctaa aagcagtcat   1320

caatgacaaa agttacaagg agaacatcat gcgcctctcc agccttcaca aggaccgccc   1380

ggtggagccg ctggacctgg ccgtgttctg ggtggagttt gtgatgaggc acaagggcgc   1440

gccacacctg cgccccgcag cccacgacct cacctggtac cagtaccatt ccttggacgt   1500

gattggtttc ctcttggccg tcgtgctgac agtggccttc atcaccttta aatgttgtgc   1560

ttatggctac cggaaatgct tggggaaaaa agggcgagtt aagaaagccc acaaatccaa   1620

gacccattga gaagtgggtg ggaaataagg taaaattttg aaccattccc tagtcatttc   1680

caaacttgaa aacagaatca gtgttaaatt cattttattc ttattaagga aatactttgc   1740

ataaattaat cagccccaga gtgctttaaa aaattctctt aaataaaaat aatagactcg   1800

ctagtcagta aagatatttg aatatgtatc gtgccccctc tggtgtcttt gatcaggatg   1860

acatgtgcca tttttcagag gacgtgcaga caggctggca ttctagatta cttttcttac   1920

tctgaaacat ggcctgtttg ggagtgcggg attcaaaggt ggtcccacgg ctgcccctac   1980

tgcaaatggc agttttaatc ttatcttttg gcttctgcag atggttgcaa ttgatcctta   2040

accaataatg gtcagtcctc atctctgtcg tgcttcatag gtgccacctt gtgtgtttaa   2100

agaagggaag ctttgtacct ttagagtgta ggtgaaatga atgaatggct tggagtgcac   2160

tgagaacagc atatgatttc ttgctttggg gaaaaagaat gatgctatga aattggtggg   2220

tggtgtattt gagaagataa tcattgctta tgtcaaatgg agctgaattt gataaaaacc   2280

caaaatacag ctatgaagtg ctgggcaagt ttactttttt tctgatgttt cctacaacta   2340

aaaataaatt aataaattta tataaattct atttaaaaaa aaaaaaaaaa aaaaa        2395


<210>  32
<211>  530
<212>  PRT
<213>  Homosapiens

<400>  32

Met Ala Cys Thr Gly Trp Thr Ser Pro Leu Pro Leu Cys Val Cys Leu 
1               5                   10                  15      


Leu Leu Thr Cys Gly Phe Ala Glu Ala Gly Lys Leu Leu Val Val Pro 
            20                  25                  30          


Met Asp Gly Ser His Trp Phe Thr Met Arg Ser Val Val Glu Lys Leu 
        35                  40                  45              


Ile Leu Arg Gly His Glu Val Val Val Val Met Pro Glu Val Ser Trp 
    50                  55                  60                  


Gln Leu Gly Arg Ser Leu Asn Cys Thr Val Lys Thr Tyr Ser Thr Ser 
65                  70                  75                  80  


Tyr Thr Leu Glu Asp Leu Asp Arg Glu Phe Lys Ala Phe Ala His Ala 
                85                  90                  95      


Gln Trp Lys Ala Gln Val Arg Ser Ile Tyr Ser Leu Leu Met Gly Ser 
            100                 105                 110         


Tyr Asn Asp Ile Phe Asp Leu Phe Phe Ser Asn Cys Arg Ser Leu Phe 
        115                 120                 125             


Lys Asp Lys Lys Leu Val Glu Tyr Leu Lys Glu Ser Ser Phe Asp Ala 
    130                 135                 140                 


Val Phe Leu Asp Pro Phe Asp Asn Cys Gly Leu Ile Val Ala Lys Tyr 
145                 150                 155                 160 


Phe Ser Leu Pro Ser Val Val Phe Ala Arg Gly Ile Leu Cys His Tyr 
                165                 170                 175     


Leu Glu Glu Gly Ala Gln Cys Pro Ala Pro Leu Ser Tyr Val Pro Arg 
            180                 185                 190         


Ile Leu Leu Gly Phe Ser Asp Ala Met Thr Phe Lys Glu Arg Val Arg 
        195                 200                 205             


Asn His Ile Met His Leu Glu Glu His Leu Leu Cys His Arg Phe Phe 
    210                 215                 220                 


Lys Asn Ala Leu Glu Ile Ala Ser Glu Ile Leu Gln Thr Pro Val Thr 
225                 230                 235                 240 


Glu Tyr Asp Leu Tyr Ser His Thr Ser Ile Trp Leu Leu Arg Thr Asp 
                245                 250                 255     


Phe Val Leu Asp Tyr Pro Lys Pro Val Met Pro Asn Met Ile Phe Ile 
            260                 265                 270         


Gly Gly Ile Asn Cys His Gln Gly Lys Pro Leu Pro Met Glu Phe Glu 
        275                 280                 285             


Ala Tyr Ile Asn Ala Ser Gly Glu His Gly Ile Val Val Phe Ser Leu 
    290                 295                 300                 


Gly Ser Met Val Ser Glu Ile Pro Glu Lys Lys Ala Met Ala Ile Ala 
305                 310                 315                 320 


Asp Ala Leu Gly Lys Ile Pro Gln Thr Val Leu Trp Arg Tyr Thr Gly 
                325                 330                 335     


Thr Arg Pro Ser Asn Leu Ala Asn Asn Thr Ile Leu Val Lys Trp Leu 
            340                 345                 350         


Pro Gln Asn Asp Leu Leu Gly His Pro Met Thr Arg Ala Phe Ile Thr 
        355                 360                 365             


His Ala Gly Ser His Gly Val Tyr Glu Ser Ile Cys Asn Gly Val Pro 
    370                 375                 380                 


Met Val Met Met Pro Leu Phe Gly Asp Gln Met Asp Asn Ala Lys Arg 
385                 390                 395                 400 


Met Glu Thr Lys Gly Ala Gly Val Thr Leu Asn Val Leu Glu Met Thr 
                405                 410                 415     


Ser Glu Asp Leu Glu Asn Ala Leu Lys Ala Val Ile Asn Asp Lys Ser 
            420                 425                 430         


Tyr Lys Glu Asn Ile Met Arg Leu Ser Ser Leu His Lys Asp Arg Pro 
        435                 440                 445             


Val Glu Pro Leu Asp Leu Ala Val Phe Trp Val Glu Phe Val Met Arg 
    450                 455                 460                 


His Lys Gly Ala Pro His Leu Arg Pro Ala Ala His Asp Leu Thr Trp 
465                 470                 475                 480 


Tyr Gln Tyr His Ser Leu Asp Val Ile Gly Phe Leu Leu Ala Val Val 
                485                 490                 495     


Leu Thr Val Ala Phe Ile Thr Phe Lys Cys Cys Ala Tyr Gly Tyr Arg 
            500                 505                 510         


Lys Cys Leu Gly Lys Lys Gly Arg Val Lys Lys Ala His Lys Ser Lys 
        515                 520                 525             


Thr His 
    530 


<210>  33
<211>  2333
<212>  DNA
<213>  Homosapiens

<400>  33
atggctcgtg cagggtggac tggcctcctt cccctatatg tgtgtctact gctgacctgt     60

ggctttgcca aggcagggaa gctgctggta gtgcccatgg atgggagcca ctggttcacc    120

atgcagtcgg tggtggagaa actcatcctc agggggcatg aggtggtcgt agtcatgcca    180

gaggtgagtt ggcaactggg aagatcactg aattgcacag tgaagactta ctcaacctca    240

tacactctgg aggatcagga ccgggagttc atggtttttg ccgatgctcg ctggacggca    300

ccattgcgaa gtgcattttc tctattaaca agttcatcca atggtatttt tgacttattt    360

ttttcaaatt gcaggagttt gtttaatgac cgaaaattag tagaatactt aaaggagagt    420

tgttttgatg cagtgtttct cgatcctttt gatgcctgtg gcttaattgt tgccaaatat    480

ttctccctcc cctctgtggt cttcgccagg ggaatatttt gccactatct tgaagaaggt    540

gcacagtgcc ctgctcctct ttcctatgtc cccagacttc tcttagggtt ctcagacgcc    600

atgactttca aggagagagt atggaaccac atcatgcact tggaggaaca tttattttgc    660

ccctattttt tcaaaaatgt cttagaaata gcctctgaaa ttctccaaac ccctgtcacg    720

gcatatgatc tctacagcca cacatcaatt tggttgttgc gaactgactt tgttttggag    780

tatcccaaac ccgtgatgcc caatatgatc ttcattggtg gtatcaactg tcatcaggga    840

aagccagtgc ctatggaatt tgaagcctac attaatgctt ctggagaaca tggaattgtg    900

gttttctctt tgggatcaat ggtctcagaa attccagaga agaaagctat ggcaattgct    960

gatgctttgg gcaaaatccc tcagacagtc ctgtggcggt acactggaac ccgaccatcg   1020

aatcttgcga acaacacgat acttgttaag tggctacccc aaaacgatct gcttggtcac   1080

ccgatgaccc gtgcctttat cacccatgct ggttcccatg gtgtttatga aagcatatgc   1140

aatggcgttc ccatggtgat gatgcccttg tttggtgatc agatggacaa tgcaaagcgc   1200

atggagacta agggagctgg agtgaccctg aatgttctgg aaatgacttc tgaagattta   1260

gaaaatgctc taaaagcagt catcaatgac aaaagttaca aggagaacat catgcgcctc   1320

tccagccttc acaaggaccg cccggtggag ccgctggacc tggccgtgtt ctgggtggag   1380

tttgtgatga ggcacaaggg cgcgccacac ctgcgccccg cagcccacga cctcacctgg   1440

taccagtacc attccttgga cgtgattggt ttcctcttgg ccgtcgtgct gacagtggcc   1500

ttcatcacct ttaaatgttg tgcttatggc taccggaaat gcttggggaa aaaagggcga   1560

gttaagaaag cccacaaatc caagacccat tgagaagtgg gtgggaaata aggtaaaatt   1620

ttgaaccatt ccctagtcat ttccaaactt gaaaacagaa tcagtgttaa attcatttta   1680

ttcttattaa ggaaatactt tgcataaatt aatcagcccc agagtgcttt aaaaaattct   1740

cttaaataaa aataatagac tcgctagtca gtaaagatat ttgaatatgt atcgtgcccc   1800

ctctggtgtc tttgatcagg atgacatgtg ccatttttca gaggacgtgc agacaggctg   1860

gcattctaga ttacttttct tactctgaaa catggcctgt ttgggagtgc gggattcaaa   1920

ggtggtccca cggctgcccc tactgcaaat ggcagtttta atcttatctt ttggcttctg   1980

cagatggttg caattgatcc ttaaccaata atggtcagtc ctcatctctg tcgtgcttca   2040

taggtgccac cttgtgtgtt taaagaaggg aagctttgta cctttagagt gtaggtgaaa   2100

tgaatgaatg gcttggagtg cactgagaac agcatatgat ttcttgcttt ggggaaaaag   2160

aatgatgcta tgaaattggt gggtggtgta tttgagaaga taatcattgc ttatgtcaaa   2220

tggagctgaa tttgataaaa acccaaaata cagctatgaa gtgctgggca agtttacttt   2280

ttttctgatg tttcctacaa ctaaaaataa attaataaat ttatataaat tct          2333


<210>  34
<211>  530
<212>  PRT
<213>  Homosapiens

<400>  34

Met Ala Arg Ala Gly Trp Thr Gly Leu Leu Pro Leu Tyr Val Cys Leu 
1               5                   10                  15      


Leu Leu Thr Cys Gly Phe Ala Lys Ala Gly Lys Leu Leu Val Val Pro 
            20                  25                  30          


Met Asp Gly Ser His Trp Phe Thr Met Gln Ser Val Val Glu Lys Leu 
        35                  40                  45              


Ile Leu Arg Gly His Glu Val Val Val Val Met Pro Glu Val Ser Trp 
    50                  55                  60                  


Gln Leu Gly Arg Ser Leu Asn Cys Thr Val Lys Thr Tyr Ser Thr Ser 
65                  70                  75                  80  


Tyr Thr Leu Glu Asp Gln Asp Arg Glu Phe Met Val Phe Ala Asp Ala 
                85                  90                  95      


Arg Trp Thr Ala Pro Leu Arg Ser Ala Phe Ser Leu Leu Thr Ser Ser 
            100                 105                 110         


Ser Asn Gly Ile Phe Asp Leu Phe Phe Ser Asn Cys Arg Ser Leu Phe 
        115                 120                 125             


Asn Asp Arg Lys Leu Val Glu Tyr Leu Lys Glu Ser Cys Phe Asp Ala 
    130                 135                 140                 


Val Phe Leu Asp Pro Phe Asp Ala Cys Gly Leu Ile Val Ala Lys Tyr 
145                 150                 155                 160 


Phe Ser Leu Pro Ser Val Val Phe Ala Arg Gly Ile Phe Cys His Tyr 
                165                 170                 175     


Leu Glu Glu Gly Ala Gln Cys Pro Ala Pro Leu Ser Tyr Val Pro Arg 
            180                 185                 190         


Leu Leu Leu Gly Phe Ser Asp Ala Met Thr Phe Lys Glu Arg Val Trp 
        195                 200                 205             


Asn His Ile Met His Leu Glu Glu His Leu Phe Cys Pro Tyr Phe Phe 
    210                 215                 220                 


Lys Asn Val Leu Glu Ile Ala Ser Glu Ile Leu Gln Thr Pro Val Thr 
225                 230                 235                 240 


Ala Tyr Asp Leu Tyr Ser His Thr Ser Ile Trp Leu Leu Arg Thr Asp 
                245                 250                 255     


Phe Val Leu Glu Tyr Pro Lys Pro Val Met Pro Asn Met Ile Phe Ile 
            260                 265                 270         


Gly Gly Ile Asn Cys His Gln Gly Lys Pro Val Pro Met Glu Phe Glu 
        275                 280                 285             


Ala Tyr Ile Asn Ala Ser Gly Glu His Gly Ile Val Val Phe Ser Leu 
    290                 295                 300                 


Gly Ser Met Val Ser Glu Ile Pro Glu Lys Lys Ala Met Ala Ile Ala 
305                 310                 315                 320 


Asp Ala Leu Gly Lys Ile Pro Gln Thr Val Leu Trp Arg Tyr Thr Gly 
                325                 330                 335     


Thr Arg Pro Ser Asn Leu Ala Asn Asn Thr Ile Leu Val Lys Trp Leu 
            340                 345                 350         


Pro Gln Asn Asp Leu Leu Gly His Pro Met Thr Arg Ala Phe Ile Thr 
        355                 360                 365             


His Ala Gly Ser His Gly Val Tyr Glu Ser Ile Cys Asn Gly Val Pro 
    370                 375                 380                 


Met Val Met Met Pro Leu Phe Gly Asp Gln Met Asp Asn Ala Lys Arg 
385                 390                 395                 400 


Met Glu Thr Lys Gly Ala Gly Val Thr Leu Asn Val Leu Glu Met Thr 
                405                 410                 415     


Ser Glu Asp Leu Glu Asn Ala Leu Lys Ala Val Ile Asn Asp Lys Ser 
            420                 425                 430         


Tyr Lys Glu Asn Ile Met Arg Leu Ser Ser Leu His Lys Asp Arg Pro 
        435                 440                 445             


Val Glu Pro Leu Asp Leu Ala Val Phe Trp Val Glu Phe Val Met Arg 
    450                 455                 460                 


His Lys Gly Ala Pro His Leu Arg Pro Ala Ala His Asp Leu Thr Trp 
465                 470                 475                 480 


Tyr Gln Tyr His Ser Leu Asp Val Ile Gly Phe Leu Leu Ala Val Val 
                485                 490                 495     


Leu Thr Val Ala Phe Ile Thr Phe Lys Cys Cys Ala Tyr Gly Tyr Arg 
            500                 505                 510         


Lys Cys Leu Gly Lys Lys Gly Arg Val Lys Lys Ala His Lys Ser Lys 
        515                 520                 525             


Thr His 
    530 


<210>  35
<211>  2435
<212>  DNA
<213>  Homosapiens

<400>  35
gaaaagcagt ggtttgttta gggaaaatac ctaggagccc tgtgatttgg agagtgaaaa     60

ctctttatta ccgttgttac tttaactctt tccaggatgg cctgcctcct tcgctcattt    120

cagagaattt ctgcaggggt tttcttctta gcactttggg gcatggttgt aggtgacaag    180

ctgctggtgg tccctcagga cggaagccac tggcttagta tgaaggatat agttgaggtt    240

ctcagtgacc ggggtcatga gattgtagtg gtggtgcctg aagttaattt gcttttgaaa    300

gaatccaaat actacacaag aaaaatctat ccagtgccgt atgaccaaga agagctgaag    360

aaccgttacc aatcatttgg aaacaatcac tttgctgagc gatcattcct aactgctcct    420

cagacagagt acaggaataa catgattgtt attggcctgt acttcatcaa ctgccagagc    480

ctcctgcagg acagggacac cctgaacttc tttaaggaga gcaagtttga tgctcttttc    540

acagacccag ccttaccctg tggggtgatc ctggctgagt atttgggcct accatctgtg    600

tacctcttca ggggttttcc gtgttccctg gagcatacat tcagcagaag cccagaccct    660

gtgtcctaca ttcccaggtg ctacacaaag ttttcagacc acatgacttt ttcccaacga    720

gtggccaact tccttgttaa tttgttggag ccctatctat tttattgtct gttttcaaag    780

tatgaagaac tcgcatcagc tgtcctcaag agagatgtgg atataatcac cttatatcag    840

aaggtctctg tttggctgtt aagatatgac tttgtgcttg aatatcctag gccggtcatg    900

cccaacatgg tcttcattgg aggtatcaac tgtaagaaga ggaaagactt gtctcaggaa    960

tttgaagcct acattaatgc ttctggagaa catggaattg tggttttctc tttgggatca   1020

atggtctcag aaattccaga gaagaaagct atggcaattg ctgatgcttt gggcaaaatc   1080

cctcagacag tcctgtggcg gtacactgga acccgaccat cgaatcttgc gaacaacacg   1140

atacttgtta agtggctacc ccaaaacgat ctgcttggtc acccgatgac ccgtgccttt   1200

atcacccatg ctggttccca tggtgtttat gaaagcatat gcaatggcgt tcccatggtg   1260

atgatgccct tgtttggtga tcagatggac aatgcaaagc gcatggagac taagggagct   1320

ggagtgaccc tgaatgttct ggaaatgact tctgaagatt tagaaaatgc tctaaaagca   1380

gtcatcaatg acaaaagtta caaggagaac atcatgcgcc tctccagcct tcacaaggac   1440

cgcccggtgg agccgctgga cctggccgtg ttctgggtgg agtttgtgat gaggcacaag   1500

ggcgcgccac acctgcgccc cgcagcccac gacctcacct ggtaccagta ccattccttg   1560

gacgtgattg gtttcctctt ggccgtcgtg ctgacagtgg ccttcatcac ctttaaatgt   1620

tgtgcttatg gctaccggaa atgcttgggg aaaaaagggc gagttaagaa agcccacaaa   1680

tccaagaccc attgagaagt gggtgggaaa taaggtaaaa ttttgaacca ttccctagtc   1740

atttccaaac ttgaaaacag aatcagtgtt aaattcattt tattcttatt aaggaaatac   1800

tttgcataaa ttaatcagcc ccagagtgct ttaaaaaatt ctcttaaata aaaataatag   1860

actcgctagt cagtaaagat atttgaatat gtatcgtgcc ccctctggtg tctttgatca   1920

ggatgacatg tgccattttt cagaggacgt gcagacaggc tggcattcta gattactttt   1980

cttactctga aacatggcct gtttgggagt gcgggattca aaggtggtcc cacggctgcc   2040

cctactgcaa atggcagttt taatcttatc ttttggcttc tgcagatggt tgcaattgat   2100

ccttaaccaa taatggtcag tcctcatctc tgtcgtgctt cataggtgcc accttgtgtg   2160

tttaaagaag ggaagctttg tacctttaga gtgtaggtga aatgaatgaa tggcttggag   2220

tgcactgaga acagcatatg atttcttgct ttggggaaaa agaatgatgc tatgaaattg   2280

gtgggtggtg tatttgagaa gataatcatt gcttatgtca aatggagctg aatttgataa   2340

aaacccaaaa tacagctatg aagtgctggg caagtttact ttttttctga tgtttcctac   2400

aactaaaaat aaattaataa atttatataa attct                              2435


<210>  36
<211>  532
<212>  PRT
<213>  Homosapiens

<400>  36

Met Ala Cys Leu Leu Arg Ser Phe Gln Arg Ile Ser Ala Gly Val Phe 
1               5                   10                  15      


Phe Leu Ala Leu Trp Gly Met Val Val Gly Asp Lys Leu Leu Val Val 
            20                  25                  30          


Pro Gln Asp Gly Ser His Trp Leu Ser Met Lys Asp Ile Val Glu Val 
        35                  40                  45              


Leu Ser Asp Arg Gly His Glu Ile Val Val Val Val Pro Glu Val Asn 
    50                  55                  60                  


Leu Leu Leu Lys Glu Ser Lys Tyr Tyr Thr Arg Lys Ile Tyr Pro Val 
65                  70                  75                  80  


Pro Tyr Asp Gln Glu Glu Leu Lys Asn Arg Tyr Gln Ser Phe Gly Asn 
                85                  90                  95      


Asn His Phe Ala Glu Arg Ser Phe Leu Thr Ala Pro Gln Thr Glu Tyr 
            100                 105                 110         


Arg Asn Asn Met Ile Val Ile Gly Leu Tyr Phe Ile Asn Cys Gln Ser 
        115                 120                 125             


Leu Leu Gln Asp Arg Asp Thr Leu Asn Phe Phe Lys Glu Ser Lys Phe 
    130                 135                 140                 


Asp Ala Leu Phe Thr Asp Pro Ala Leu Pro Cys Gly Val Ile Leu Ala 
145                 150                 155                 160 


Glu Tyr Leu Gly Leu Pro Ser Val Tyr Leu Phe Arg Gly Phe Pro Cys 
                165                 170                 175     


Ser Leu Glu His Thr Phe Ser Arg Ser Pro Asp Pro Val Ser Tyr Ile 
            180                 185                 190         


Pro Arg Cys Tyr Thr Lys Phe Ser Asp His Met Thr Phe Ser Gln Arg 
        195                 200                 205             


Val Ala Asn Phe Leu Val Asn Leu Leu Glu Pro Tyr Leu Phe Tyr Cys 
    210                 215                 220                 


Leu Phe Ser Lys Tyr Glu Glu Leu Ala Ser Ala Val Leu Lys Arg Asp 
225                 230                 235                 240 


Val Asp Ile Ile Thr Leu Tyr Gln Lys Val Ser Val Trp Leu Leu Arg 
                245                 250                 255     


Tyr Asp Phe Val Leu Glu Tyr Pro Arg Pro Val Met Pro Asn Met Val 
            260                 265                 270         


Phe Ile Gly Gly Ile Asn Cys Lys Lys Arg Lys Asp Leu Ser Gln Glu 
        275                 280                 285             


Phe Glu Ala Tyr Ile Asn Ala Ser Gly Glu His Gly Ile Val Val Phe 
    290                 295                 300                 


Ser Leu Gly Ser Met Val Ser Glu Ile Pro Glu Lys Lys Ala Met Ala 
305                 310                 315                 320 


Ile Ala Asp Ala Leu Gly Lys Ile Pro Gln Thr Val Leu Trp Arg Tyr 
                325                 330                 335     


Thr Gly Thr Arg Pro Ser Asn Leu Ala Asn Asn Thr Ile Leu Val Lys 
            340                 345                 350         


Trp Leu Pro Gln Asn Asp Leu Leu Gly His Pro Met Thr Arg Ala Phe 
        355                 360                 365             


Ile Thr His Ala Gly Ser His Gly Val Tyr Glu Ser Ile Cys Asn Gly 
    370                 375                 380                 


Val Pro Met Val Met Met Pro Leu Phe Gly Asp Gln Met Asp Asn Ala 
385                 390                 395                 400 


Lys Arg Met Glu Thr Lys Gly Ala Gly Val Thr Leu Asn Val Leu Glu 
                405                 410                 415     


Met Thr Ser Glu Asp Leu Glu Asn Ala Leu Lys Ala Val Ile Asn Asp 
            420                 425                 430         


Lys Ser Tyr Lys Glu Asn Ile Met Arg Leu Ser Ser Leu His Lys Asp 
        435                 440                 445             


Arg Pro Val Glu Pro Leu Asp Leu Ala Val Phe Trp Val Glu Phe Val 
    450                 455                 460                 


Met Arg His Lys Gly Ala Pro His Leu Arg Pro Ala Ala His Asp Leu 
465                 470                 475                 480 


Thr Trp Tyr Gln Tyr His Ser Leu Asp Val Ile Gly Phe Leu Leu Ala 
                485                 490                 495     


Val Val Leu Thr Val Ala Phe Ile Thr Phe Lys Cys Cys Ala Tyr Gly 
            500                 505                 510         


Tyr Arg Lys Cys Leu Gly Lys Lys Gly Arg Val Lys Lys Ala His Lys 
        515                 520                 525             


Ser Lys Thr His 
    530         


<210>  37
<211>  1691
<212>  DNA
<213>  Homosapiens

<400>  37
agaaacctga agctcaggag aggagtcact cccctggcag atgggtggct gggccagaag     60

cagataccag gctttctgac tcctgctcta ggattctcac cacgtactgg ctagacttat    120

acttctcaaa tcttaatttc ctaaaggccg gtcatgccca acatggtctt cattggaggt    180

atcaactgta agaagaggaa agacttgtct caggaatttg aagcctacat taatgcttct    240

ggagaacatg gaattgtggt tttctctttg ggatcaatgg tctcagaaat tccagagaag    300

aaagctatgg caattgctga tgctttgggc aaaatccctc agacagtcct gtggcggtac    360

actggaaccc gaccatcgaa tcttgcgaac aacacgatac ttgttaagtg gctaccccaa    420

aacgatctgc ttggtcaccc gatgacccgt gcctttatca cccatgctgg ttcccatggt    480

gtttatgaaa gcatatgcaa tggcgttccc atggtgatga tgcccttgtt tggtgatcag    540

atggacaatg caaagcgcat ggagactaag ggagctggag tgaccctgaa tgttctggaa    600

atgacttctg aagatttaga aaatgctcta aaagcagtca tcaatgacaa aagttacaag    660

gagaacatca tgcgcctctc cagccttcac aaggaccgcc cggtggagcc gctggacctg    720

gccgtgttct gggtggagtt tgtgatgagg cacaagggcg cgccacacct gcgccccgca    780

gcccacgacc tcacctggta ccagtaccat tccttggacg tgattggttt cctcttggcc    840

gtcgtgctga cagtggcctt catcaccttt aaatgttgtg cttatggcta ccggaaatgc    900

ttggggaaaa aagggcgagt taagaaagcc cacaaatcca agacccattg agaagtgggt    960

gggaaataag gtaaaatttt gaaccattcc ctagtcattt ccaaacttga aaacagaatc   1020

agtgttaaat tcattttatt cttattaagg aaatactttg cataaattaa tcagccccag   1080

agtgctttaa aaaattctct taaataaaaa taatagactc gctagtcagt aaagatattt   1140

gaatatgtat cgtgccccct ctggtgtctt tgatcaggat gacatgtgcc atttttcaga   1200

ggacgtgcag acaggctggc attctagatt acttttctta ctctgaaaca tggcctgttt   1260

gggagtgcgg gattcaaagg tggtcccacg gctgccccta ctgcaaatgg cagttttaat   1320

cttatctttt ggcttctgca gatggttgca attgatcctt aaccaataat ggtcagtcct   1380

catctctgtc gtgcttcata ggtgccacct tgtgtgttta aagaagggaa gctttgtacc   1440

tttagagtgt aggtgaaatg aatgaatggc ttggagtgca ctgagaacag catatgattt   1500

cttgctttgg ggaaaaagaa tgatgctatg aaattggtgg gtggtgtatt tgagaagata   1560

atcattgctt atgtcaaatg gagctgaatt tgataaaaac ccaaaataca gctatgaagt   1620

gctgggcaag tttacttttt ttctgatgtt tcctacaact aaaaataaat taataaattt   1680

atataaattc t                                                        1691


<210>  38
<211>  265
<212>  PRT
<213>  Homosapiens

<400>  38

Met Pro Asn Met Val Phe Ile Gly Gly Ile Asn Cys Lys Lys Arg Lys 
1               5                   10                  15      


Asp Leu Ser Gln Glu Phe Glu Ala Tyr Ile Asn Ala Ser Gly Glu His 
            20                  25                  30          


Gly Ile Val Val Phe Ser Leu Gly Ser Met Val Ser Glu Ile Pro Glu 
        35                  40                  45              


Lys Lys Ala Met Ala Ile Ala Asp Ala Leu Gly Lys Ile Pro Gln Thr 
    50                  55                  60                  


Val Leu Trp Arg Tyr Thr Gly Thr Arg Pro Ser Asn Leu Ala Asn Asn 
65                  70                  75                  80  


Thr Ile Leu Val Lys Trp Leu Pro Gln Asn Asp Leu Leu Gly His Pro 
                85                  90                  95      


Met Thr Arg Ala Phe Ile Thr His Ala Gly Ser His Gly Val Tyr Glu 
            100                 105                 110         


Ser Ile Cys Asn Gly Val Pro Met Val Met Met Pro Leu Phe Gly Asp 
        115                 120                 125             


Gln Met Asp Asn Ala Lys Arg Met Glu Thr Lys Gly Ala Gly Val Thr 
    130                 135                 140                 


Leu Asn Val Leu Glu Met Thr Ser Glu Asp Leu Glu Asn Ala Leu Lys 
145                 150                 155                 160 


Ala Val Ile Asn Asp Lys Ser Tyr Lys Glu Asn Ile Met Arg Leu Ser 
                165                 170                 175     


Ser Leu His Lys Asp Arg Pro Val Glu Pro Leu Asp Leu Ala Val Phe 
            180                 185                 190         


Trp Val Glu Phe Val Met Arg His Lys Gly Ala Pro His Leu Arg Pro 
        195                 200                 205             


Ala Ala His Asp Leu Thr Trp Tyr Gln Tyr His Ser Leu Asp Val Ile 
    210                 215                 220                 


Gly Phe Leu Leu Ala Val Val Leu Thr Val Ala Phe Ile Thr Phe Lys 
225                 230                 235                 240 


Cys Cys Ala Tyr Gly Tyr Arg Lys Cys Leu Gly Lys Lys Gly Arg Val 
                245                 250                 255     


Lys Lys Ala His Lys Ser Lys Thr His 
            260                 265 


<210>  39
<211>  2345
<212>  DNA
<213>  Homosapiens

<400>  39
atggccacag gactccaggt tcccctgccg cagctggcca caggactgct gcttctcctc     60

agtgtccagc cctgggctga gagtgggaag gtgctggtgg tgcccactga tggcagccac    120

tggctcagca tgcgggaggc cttgcgggac ctccatgcga gaggccacca ggtggtggtc    180

ctcaccctgg aggtgaatat gtacatcaaa gaagagaact ttttcaccct gacaacgtat    240

gccatttcat ggacccagga cgaatttgat cgccttttgc tgggtcacac tcaatcgttc    300

tttgaaacag aacatcttct gatgaaattt tctagaagaa tggcaattat gaacaatatg    360

tctttgatca tacataggtc ttgtgtggag ctactgcata atgaggccct gatcaggcac    420

ctgcatgcta cttcctttga tgtggttcta acagacccct ttcacctctg cgcggcggtg    480

ctggctaagt acctgtcgat tcctgctgtg tttttcttga ggaacattcc atgtgattta    540

gactttaagg gcacacagtg tccaaaccct tcctcctata ttcctagatt actaacgacc    600

aattcagacc acatgacatt cctgcaaagg gtcaagaaca tgctctaccc tctggccctg    660

tcctaccttt gccatgctgt ttctgctcct tatgcaagcc ttgcctctga gctttttcag    720

agagaggtgt cagtggtgga tcttgtcagc catgcatctg tgtggctgtt ccgaggggac    780

tttgtgatgg attaccccag gccgatcatg cccaacatgg tcttcattgg gggcatcaac    840

tgtgccaacg ggaagccact atctcaggaa tttgaagcct acattaatgc ttctggagaa    900

catggaattg tggttttctc tttgggatca atggtctcag aaattccaga gaagaaagct    960

atggcaattg ctgatgcttt gggcaaaatc cctcagacag tcctgtggcg gtacactgga   1020

acccgaccat cgaatcttgc gaacaacacg atacttgtta agtggctacc ccaaaacgat   1080

ctgcttggtc acccgatgac ccgtgccttt atcacccatg ctggttccca tggtgtttat   1140

gaaagcatat gcaatggcgt tcccatggtg atgatgccct tgtttggtga tcagatggac   1200

aatgcaaagc gcatggagac taagggagct ggagtgaccc tgaatgttct ggaaatgact   1260

tctgaagatt tagaaaatgc tctaaaagca gtcatcaatg acaaaagtta caaggagaac   1320

atcatgcgcc tctccagcct tcacaaggac cgcccggtgg agccgctgga cctggccgtg   1380

ttctgggtgg agtttgtgat gaggcacaag ggcgcgccac acctgcgccc cgcagcccac   1440

gacctcacct ggtaccagta ccattccttg gacgtgattg gtttcctctt ggccgtcgtg   1500

ctgacagtgg ccttcatcac ctttaaatgt tgtgcttatg gctaccggaa atgcttgggg   1560

aaaaaagggc gagttaagaa agcccacaaa tccaagaccc attgagaagt gggtgggaaa   1620

taaggtaaaa ttttgaacca ttccctagtc atttccaaac ttgaaaacag aatcagtgtt   1680

aaattcattt tattcttatt aaggaaatac tttgcataaa ttaatcagcc ccagagtgct   1740

ttaaaaaatt ctcttaaata aaaataatag actcgctagt cagtaaagat atttgaatat   1800

gtatcgtgcc ccctctggtg tctttgatca ggatgacatg tgccattttt cagaggacgt   1860

gcagacaggc tggcattcta gattactttt cttactctga aacatggcct gtttgggagt   1920

gcgggattca aaggtggtcc cacggctgcc cctactgcaa atggcagttt taatcttatc   1980

ttttggcttc tgcagatggt tgcaattgat ccttaaccaa taatggtcag tcctcatctc   2040

tgtcgtgctt cataggtgcc accttgtgtg tttaaagaag ggaagctttg tacctttaga   2100

gtgtaggtga aatgaatgaa tggcttggag tgcactgaga acagcatatg atttcttgct   2160

ttggggaaaa agaatgatgc tatgaaattg gtgggtggtg tatttgagaa gataatcatt   2220

gcttatgtca aatggagctg aatttgataa aaacccaaaa tacagctatg aagtgctggg   2280

caagtttact ttttttctga tgtttcctac aactaaaaat aaattaataa atttatataa   2340

attct                                                               2345


<210>  40
<211>  534
<212>  PRT
<213>  Homosapiens

<400>  40

Met Ala Thr Gly Leu Gln Val Pro Leu Pro Gln Leu Ala Thr Gly Leu 
1               5                   10                  15      


Leu Leu Leu Leu Ser Val Gln Pro Trp Ala Glu Ser Gly Lys Val Leu 
            20                  25                  30          


Val Val Pro Thr Asp Gly Ser His Trp Leu Ser Met Arg Glu Ala Leu 
        35                  40                  45              


Arg Asp Leu His Ala Arg Gly His Gln Val Val Val Leu Thr Leu Glu 
    50                  55                  60                  


Val Asn Met Tyr Ile Lys Glu Glu Asn Phe Phe Thr Leu Thr Thr Tyr 
65                  70                  75                  80  


Ala Ile Ser Trp Thr Gln Asp Glu Phe Asp Arg Leu Leu Leu Gly His 
                85                  90                  95      


Thr Gln Ser Phe Phe Glu Thr Glu His Leu Leu Met Lys Phe Ser Arg 
            100                 105                 110         


Arg Met Ala Ile Met Asn Asn Met Ser Leu Ile Ile His Arg Ser Cys 
        115                 120                 125             


Val Glu Leu Leu His Asn Glu Ala Leu Ile Arg His Leu His Ala Thr 
    130                 135                 140                 


Ser Phe Asp Val Val Leu Thr Asp Pro Phe His Leu Cys Ala Ala Val 
145                 150                 155                 160 


Leu Ala Lys Tyr Leu Ser Ile Pro Ala Val Phe Phe Leu Arg Asn Ile 
                165                 170                 175     


Pro Cys Asp Leu Asp Phe Lys Gly Thr Gln Cys Pro Asn Pro Ser Ser 
            180                 185                 190         


Tyr Ile Pro Arg Leu Leu Thr Thr Asn Ser Asp His Met Thr Phe Leu 
        195                 200                 205             


Gln Arg Val Lys Asn Met Leu Tyr Pro Leu Ala Leu Ser Tyr Leu Cys 
    210                 215                 220                 


His Ala Val Ser Ala Pro Tyr Ala Ser Leu Ala Ser Glu Leu Phe Gln 
225                 230                 235                 240 


Arg Glu Val Ser Val Val Asp Leu Val Ser His Ala Ser Val Trp Leu 
                245                 250                 255     


Phe Arg Gly Asp Phe Val Met Asp Tyr Pro Arg Pro Ile Met Pro Asn 
            260                 265                 270         


Met Val Phe Ile Gly Gly Ile Asn Cys Ala Asn Gly Lys Pro Leu Ser 
        275                 280                 285             


Gln Glu Phe Glu Ala Tyr Ile Asn Ala Ser Gly Glu His Gly Ile Val 
    290                 295                 300                 


Val Phe Ser Leu Gly Ser Met Val Ser Glu Ile Pro Glu Lys Lys Ala 
305                 310                 315                 320 


Met Ala Ile Ala Asp Ala Leu Gly Lys Ile Pro Gln Thr Val Leu Trp 
                325                 330                 335     


Arg Tyr Thr Gly Thr Arg Pro Ser Asn Leu Ala Asn Asn Thr Ile Leu 
            340                 345                 350         


Val Lys Trp Leu Pro Gln Asn Asp Leu Leu Gly His Pro Met Thr Arg 
        355                 360                 365             


Ala Phe Ile Thr His Ala Gly Ser His Gly Val Tyr Glu Ser Ile Cys 
    370                 375                 380                 


Asn Gly Val Pro Met Val Met Met Pro Leu Phe Gly Asp Gln Met Asp 
385                 390                 395                 400 


Asn Ala Lys Arg Met Glu Thr Lys Gly Ala Gly Val Thr Leu Asn Val 
                405                 410                 415     


Leu Glu Met Thr Ser Glu Asp Leu Glu Asn Ala Leu Lys Ala Val Ile 
            420                 425                 430         


Asn Asp Lys Ser Tyr Lys Glu Asn Ile Met Arg Leu Ser Ser Leu His 
        435                 440                 445             


Lys Asp Arg Pro Val Glu Pro Leu Asp Leu Ala Val Phe Trp Val Glu 
    450                 455                 460                 


Phe Val Met Arg His Lys Gly Ala Pro His Leu Arg Pro Ala Ala His 
465                 470                 475                 480 


Asp Leu Thr Trp Tyr Gln Tyr His Ser Leu Asp Val Ile Gly Phe Leu 
                485                 490                 495     


Leu Ala Val Val Leu Thr Val Ala Phe Ile Thr Phe Lys Cys Cys Ala 
            500                 505                 510         


Tyr Gly Tyr Arg Lys Cys Leu Gly Lys Lys Gly Arg Val Lys Lys Ala 
        515                 520                 525             


His Lys Ser Lys Thr His 
    530                 


<210>  41
<211>  2374
<212>  DNA
<213>  Homosapiens

<400>  41
acagtcagct gtcggtggct tctgctgaga tggccagagg actccaggtt cccctgccgc     60

ggctggccac aggactgctg ctcctcctca gtgtccagcc ctgggctgag agtggaaagg    120

tgttggtggt gcccactgat ggcagcccct ggctcagcat gcgggaggcc ttgcgggagc    180

tccatgccag aggccaccag gcggtggtcc tcaccccaga ggtgaatatg cacatcaaag    240

aagagaaatt tttcaccctg acagcctatg ctgttccatg gacccagaag gaatttgatc    300

gcgttacgct gggctacact caagggttct ttgaaacaga acatcttctg aagagatatt    360

ctagaagtat ggcaattatg aacaatgtat ctttggccct tcataggtgt tgtgtggagc    420

tactgcataa tgaggccctg atcaggcacc tgaatgctac ttcctttgat gtggttttaa    480

cagaccccgt taacctctgt ggggcggtgc tggctaagta cctgtcgatt cctgctgtgt    540

ttttttggag gtacattcca tgtgacttag actttaaggg cacacagtgt ccaaatcctt    600

cctcctatat tcctaagtta ctaacgacca attcagacca catgacattc ctgcaaaggg    660

tcaagaacat gctctaccct ctggccctgt cctacatttg ccatactttt tctgcccctt    720

atgcaagtct tgcctctgag ctttttcaga gagaggtgtc agtggtggat cttgtcagct    780

atgcatccgt gtggctgttc cgaggggact ttgtgatgga ctaccccagg ccgatcatgc    840

ccaacatggt cttcattggg ggcatcaact gtgccaacgg gaagccacta tctcaggaat    900

ttgaagccta cattaatgct tctggagaac atggaattgt ggttttctct ttgggatcaa    960

tggtctcaga aattccagag aagaaagcta tggcaattgc tgatgctttg ggcaaaatcc   1020

ctcagacagt cctgtggcgg tacactggaa cccgaccatc gaatcttgcg aacaacacga   1080

tacttgttaa gtggctaccc caaaacgatc tgcttggtca cccgatgacc cgtgccttta   1140

tcacccatgc tggttcccat ggtgtttatg aaagcatatg caatggcgtt cccatggtga   1200

tgatgccctt gtttggtgat cagatggaca atgcaaagcg catggagact aagggagctg   1260

gagtgaccct gaatgttctg gaaatgactt ctgaagattt agaaaatgct ctaaaagcag   1320

tcatcaatga caaaagttac aaggagaaca tcatgcgcct ctccagcctt cacaaggacc   1380

gcccggtgga gccgctggac ctggccgtgt tctgggtgga gtttgtgatg aggcacaagg   1440

gcgcgccaca cctgcgcccc gcagcccacg acctcacctg gtaccagtac cattccttgg   1500

acgtgattgg tttcctcttg gccgtcgtgc tgacagtggc cttcatcacc tttaaatgtt   1560

gtgcttatgg ctaccggaaa tgcttgggga aaaaagggcg agttaagaaa gcccacaaat   1620

ccaagaccca ttgagaagtg ggtgggaaat aaggtaaaat tttgaaccat tccctagtca   1680

tttccaaact tgaaaacaga atcagtgtta aattcatttt attcttatta aggaaatact   1740

ttgcataaat taatcagccc cagagtgctt taaaaaattc tcttaaataa aaataataga   1800

ctcgctagtc agtaaagata tttgaatatg tatcgtgccc cctctggtgt ctttgatcag   1860

gatgacatgt gccatttttc agaggacgtg cagacaggct ggcattctag attacttttc   1920

ttactctgaa acatggcctg tttgggagtg cgggattcaa aggtggtccc acggctgccc   1980

ctactgcaaa tggcagtttt aatcttatct tttggcttct gcagatggtt gcaattgatc   2040

cttaaccaat aatggtcagt cctcatctct gtcgtgcttc ataggtgcca ccttgtgtgt   2100

ttaaagaagg gaagctttgt acctttagag tgtaggtgaa atgaatgaat ggcttggagt   2160

gcactgagaa cagcatatga tttcttgctt tggggaaaaa gaatgatgct atgaaattgg   2220

tgggtggtgt atttgagaag ataatcattg cttatgtcaa atggagctga atttgataaa   2280

aacccaaaat acagctatga agtgctgggc aagtttactt tttttctgat gtttcctaca   2340

actaaaaata aattaataaa tttatataaa ttct                               2374


<210>  42
<211>  534
<212>  PRT
<213>  Homosapiens

<400>  42

Met Ala Arg Gly Leu Gln Val Pro Leu Pro Arg Leu Ala Thr Gly Leu 
1               5                   10                  15      


Leu Leu Leu Leu Ser Val Gln Pro Trp Ala Glu Ser Gly Lys Val Leu 
            20                  25                  30          


Val Val Pro Thr Asp Gly Ser Pro Trp Leu Ser Met Arg Glu Ala Leu 
        35                  40                  45              


Arg Glu Leu His Ala Arg Gly His Gln Ala Val Val Leu Thr Pro Glu 
    50                  55                  60                  


Val Asn Met His Ile Lys Glu Glu Lys Phe Phe Thr Leu Thr Ala Tyr 
65                  70                  75                  80  


Ala Val Pro Trp Thr Gln Lys Glu Phe Asp Arg Val Thr Leu Gly Tyr 
                85                  90                  95      


Thr Gln Gly Phe Phe Glu Thr Glu His Leu Leu Lys Arg Tyr Ser Arg 
            100                 105                 110         


Ser Met Ala Ile Met Asn Asn Val Ser Leu Ala Leu His Arg Cys Cys 
        115                 120                 125             


Val Glu Leu Leu His Asn Glu Ala Leu Ile Arg His Leu Asn Ala Thr 
    130                 135                 140                 


Ser Phe Asp Val Val Leu Thr Asp Pro Val Asn Leu Cys Gly Ala Val 
145                 150                 155                 160 


Leu Ala Lys Tyr Leu Ser Ile Pro Ala Val Phe Phe Trp Arg Tyr Ile 
                165                 170                 175     


Pro Cys Asp Leu Asp Phe Lys Gly Thr Gln Cys Pro Asn Pro Ser Ser 
            180                 185                 190         


Tyr Ile Pro Lys Leu Leu Thr Thr Asn Ser Asp His Met Thr Phe Leu 
        195                 200                 205             


Gln Arg Val Lys Asn Met Leu Tyr Pro Leu Ala Leu Ser Tyr Ile Cys 
    210                 215                 220                 


His Thr Phe Ser Ala Pro Tyr Ala Ser Leu Ala Ser Glu Leu Phe Gln 
225                 230                 235                 240 


Arg Glu Val Ser Val Val Asp Leu Val Ser Tyr Ala Ser Val Trp Leu 
                245                 250                 255     


Phe Arg Gly Asp Phe Val Met Asp Tyr Pro Arg Pro Ile Met Pro Asn 
            260                 265                 270         


Met Val Phe Ile Gly Gly Ile Asn Cys Ala Asn Gly Lys Pro Leu Ser 
        275                 280                 285             


Gln Glu Phe Glu Ala Tyr Ile Asn Ala Ser Gly Glu His Gly Ile Val 
    290                 295                 300                 


Val Phe Ser Leu Gly Ser Met Val Ser Glu Ile Pro Glu Lys Lys Ala 
305                 310                 315                 320 


Met Ala Ile Ala Asp Ala Leu Gly Lys Ile Pro Gln Thr Val Leu Trp 
                325                 330                 335     


Arg Tyr Thr Gly Thr Arg Pro Ser Asn Leu Ala Asn Asn Thr Ile Leu 
            340                 345                 350         


Val Lys Trp Leu Pro Gln Asn Asp Leu Leu Gly His Pro Met Thr Arg 
        355                 360                 365             


Ala Phe Ile Thr His Ala Gly Ser His Gly Val Tyr Glu Ser Ile Cys 
    370                 375                 380                 


Asn Gly Val Pro Met Val Met Met Pro Leu Phe Gly Asp Gln Met Asp 
385                 390                 395                 400 


Asn Ala Lys Arg Met Glu Thr Lys Gly Ala Gly Val Thr Leu Asn Val 
                405                 410                 415     


Leu Glu Met Thr Ser Glu Asp Leu Glu Asn Ala Leu Lys Ala Val Ile 
            420                 425                 430         


Asn Asp Lys Ser Tyr Lys Glu Asn Ile Met Arg Leu Ser Ser Leu His 
        435                 440                 445             


Lys Asp Arg Pro Val Glu Pro Leu Asp Leu Ala Val Phe Trp Val Glu 
    450                 455                 460                 


Phe Val Met Arg His Lys Gly Ala Pro His Leu Arg Pro Ala Ala His 
465                 470                 475                 480 


Asp Leu Thr Trp Tyr Gln Tyr His Ser Leu Asp Val Ile Gly Phe Leu 
                485                 490                 495     


Leu Ala Val Val Leu Thr Val Ala Phe Ile Thr Phe Lys Cys Cys Ala 
            500                 505                 510         


Tyr Gly Tyr Arg Lys Cys Leu Gly Lys Lys Gly Arg Val Lys Lys Ala 
        515                 520                 525             


His Lys Ser Lys Thr His 
    530                 


<210>  43
<211>  2345
<212>  DNA
<213>  Homosapiens

<400>  43
atggccacag gactccaggt tcccctgccg tggctggcca caggactgct gcttctcctc     60

agtgtccagc cctgggctga gagtggaaag gtgttggtgg tgcccattga tggcagccac    120

tggctcagca tgcgggaggt cttgcgggag ctccatgcca gaggccacca ggcagtggtc    180

ctcaccccag aggtgaatat gcacatcaaa gaagagaact ttttcaccct gacaacctat    240

gccatttcgt ggacccagga tgaatttgat cgccatgtgc tgggccacac tcaactgtac    300

tttgaaacag aacattttct gaagaaattt ttcagaagta tggcaatgtt gaacaatatg    360

tctttggtct atcataggtc ttgtgtggag ctactacata atgaggccct gatcaggcac    420

ctgaatgcta cttcctttga tgtggtttta acagaccccg ttaacctctg cgcggcagtg    480

ctggctaagt acctgtcgat tcctactgtg ttttttttga ggaacattcc atgtgattta    540

gactttaagg gcacacagtg tccaaaccct tcctcctata ttcctagatt actaacaacc    600

aattcagacc acatgacatt catgcaaagg gtcaagaaca tgctctaccc tctggccctg    660

tcctacattt gccatgcttt ttctgctcct tatgcaagcc ttgcctctga gctttttcag    720

agagaggtgt cagtggtgga tattctcagt catgcatctg tgtggctgtt ccgaggggac    780

tttgtgatgg actaccccag gccaatcatg cccaacatgg tcttcattgg gggcatcaac    840

tgtgccaaca ggaagccact atctcaggaa tttgaagcct acattaatgc ttctggagaa    900

catggaattg tggttttctc tttgggatca atggtctcag aaattccaga gaagaaagct    960

atggcaattg ctgatgcttt gggcaaaatc cctcagacag tcctgtggcg gtacactgga   1020

acccgaccat cgaatcttgc gaacaacacg atacttgtta agtggctacc ccaaaacgat   1080

ctgcttggtc acccgatgac ccgtgccttt atcacccatg ctggttccca tggtgtttat   1140

gaaagcatat gcaatggcgt tcccatggtg atgatgccct tgtttggtga tcagatggac   1200

aatgcaaagc gcatggagac taagggagct ggagtgaccc tgaatgttct ggaaatgact   1260

tctgaagatt tagaaaatgc tctaaaagca gtcatcaatg acaaaagtta caaggagaac   1320

atcatgcgcc tctccagcct tcacaaggac cgcccggtgg agccgctgga cctggccgtg   1380

ttctgggtgg agtttgtgat gaggcacaag ggcgcgccac acctgcgccc cgcagcccac   1440

gacctcacct ggtaccagta ccattccttg gacgtgattg gtttcctctt ggccgtcgtg   1500

ctgacagtgg ccttcatcac ctttaaatgt tgtgcttatg gctaccggaa atgcttgggg   1560

aaaaaagggc gagttaagaa agcccacaaa tccaagaccc attgagaagt gggtgggaaa   1620

taaggtaaaa ttttgaacca ttccctagtc atttccaaac ttgaaaacag aatcagtgtt   1680

aaattcattt tattcttatt aaggaaatac tttgcataaa ttaatcagcc ccagagtgct   1740

ttaaaaaatt ctcttaaata aaaataatag actcgctagt cagtaaagat atttgaatat   1800

gtatcgtgcc ccctctggtg tctttgatca ggatgacatg tgccattttt cagaggacgt   1860

gcagacaggc tggcattcta gattactttt cttactctga aacatggcct gtttgggagt   1920

gcgggattca aaggtggtcc cacggctgcc cctactgcaa atggcagttt taatcttatc   1980

ttttggcttc tgcagatggt tgcaattgat ccttaaccaa taatggtcag tcctcatctc   2040

tgtcgtgctt cataggtgcc accttgtgtg tttaaagaag ggaagctttg tacctttaga   2100

gtgtaggtga aatgaatgaa tggcttggag tgcactgaga acagcatatg atttcttgct   2160

ttggggaaaa agaatgatgc tatgaaattg gtgggtggtg tatttgagaa gataatcatt   2220

gcttatgtca aatggagctg aatttgataa aaacccaaaa tacagctatg aagtgctggg   2280

caagtttact ttttttctga tgtttcctac aactaaaaat aaattaataa atttatataa   2340

attct                                                               2345


<210>  44
<211>  534
<212>  PRT
<213>  Homosapiens

<400>  44

Met Ala Thr Gly Leu Gln Val Pro Leu Pro Trp Leu Ala Thr Gly Leu 
1               5                   10                  15      


Leu Leu Leu Leu Ser Val Gln Pro Trp Ala Glu Ser Gly Lys Val Leu 
            20                  25                  30          


Val Val Pro Ile Asp Gly Ser His Trp Leu Ser Met Arg Glu Val Leu 
        35                  40                  45              


Arg Glu Leu His Ala Arg Gly His Gln Ala Val Val Leu Thr Pro Glu 
    50                  55                  60                  


Val Asn Met His Ile Lys Glu Glu Asn Phe Phe Thr Leu Thr Thr Tyr 
65                  70                  75                  80  


Ala Ile Ser Trp Thr Gln Asp Glu Phe Asp Arg His Val Leu Gly His 
                85                  90                  95      


Thr Gln Leu Tyr Phe Glu Thr Glu His Phe Leu Lys Lys Phe Phe Arg 
            100                 105                 110         


Ser Met Ala Met Leu Asn Asn Met Ser Leu Val Tyr His Arg Ser Cys 
        115                 120                 125             


Val Glu Leu Leu His Asn Glu Ala Leu Ile Arg His Leu Asn Ala Thr 
    130                 135                 140                 


Ser Phe Asp Val Val Leu Thr Asp Pro Val Asn Leu Cys Ala Ala Val 
145                 150                 155                 160 


Leu Ala Lys Tyr Leu Ser Ile Pro Thr Val Phe Phe Leu Arg Asn Ile 
                165                 170                 175     


Pro Cys Asp Leu Asp Phe Lys Gly Thr Gln Cys Pro Asn Pro Ser Ser 
            180                 185                 190         


Tyr Ile Pro Arg Leu Leu Thr Thr Asn Ser Asp His Met Thr Phe Met 
        195                 200                 205             


Gln Arg Val Lys Asn Met Leu Tyr Pro Leu Ala Leu Ser Tyr Ile Cys 
    210                 215                 220                 


His Ala Phe Ser Ala Pro Tyr Ala Ser Leu Ala Ser Glu Leu Phe Gln 
225                 230                 235                 240 


Arg Glu Val Ser Val Val Asp Ile Leu Ser His Ala Ser Val Trp Leu 
                245                 250                 255     


Phe Arg Gly Asp Phe Val Met Asp Tyr Pro Arg Pro Ile Met Pro Asn 
            260                 265                 270         


Met Val Phe Ile Gly Gly Ile Asn Cys Ala Asn Arg Lys Pro Leu Ser 
        275                 280                 285             


Gln Glu Phe Glu Ala Tyr Ile Asn Ala Ser Gly Glu His Gly Ile Val 
    290                 295                 300                 


Val Phe Ser Leu Gly Ser Met Val Ser Glu Ile Pro Glu Lys Lys Ala 
305                 310                 315                 320 


Met Ala Ile Ala Asp Ala Leu Gly Lys Ile Pro Gln Thr Val Leu Trp 
                325                 330                 335     


Arg Tyr Thr Gly Thr Arg Pro Ser Asn Leu Ala Asn Asn Thr Ile Leu 
            340                 345                 350         


Val Lys Trp Leu Pro Gln Asn Asp Leu Leu Gly His Pro Met Thr Arg 
        355                 360                 365             


Ala Phe Ile Thr His Ala Gly Ser His Gly Val Tyr Glu Ser Ile Cys 
    370                 375                 380                 


Asn Gly Val Pro Met Val Met Met Pro Leu Phe Gly Asp Gln Met Asp 
385                 390                 395                 400 


Asn Ala Lys Arg Met Glu Thr Lys Gly Ala Gly Val Thr Leu Asn Val 
                405                 410                 415     


Leu Glu Met Thr Ser Glu Asp Leu Glu Asn Ala Leu Lys Ala Val Ile 
            420                 425                 430         


Asn Asp Lys Ser Tyr Lys Glu Asn Ile Met Arg Leu Ser Ser Leu His 
        435                 440                 445             


Lys Asp Arg Pro Val Glu Pro Leu Asp Leu Ala Val Phe Trp Val Glu 
    450                 455                 460                 


Phe Val Met Arg His Lys Gly Ala Pro His Leu Arg Pro Ala Ala His 
465                 470                 475                 480 


Asp Leu Thr Trp Tyr Gln Tyr His Ser Leu Asp Val Ile Gly Phe Leu 
                485                 490                 495     


Leu Ala Val Val Leu Thr Val Ala Phe Ile Thr Phe Lys Cys Cys Ala 
            500                 505                 510         


Tyr Gly Tyr Arg Lys Cys Leu Gly Lys Lys Gly Arg Val Lys Lys Ala 
        515                 520                 525             


His Lys Ser Lys Thr His 
    530                 


<210>  45
<211>  2357
<212>  DNA
<213>  Homosapiens

<400>  45
aggagcaaag gcgccatggc tgtggagtcc cagggcggac gcccacttgt cctgggcctg     60

ctgctgtgtg tgctgggccc agtggtgtcc catgctggga agatactgtt gatcccagtg    120

gatggcagcc actggctgag catgcttggg gccatccagc agctgcagca gaggggacat    180

gaaatagttg tcctagcacc tgacgcctcg ttgtacatca gagacggagc attttacacc    240

ttgaagacgt accctgtgcc attccaaagg gaggatgtga aagagtcttt tgttagtctc    300

gggcataatg tttttgagaa tgattctttc ctgcagcgtg tgatcaaaac atacaagaaa    360

ataaaaaagg actctgctat gcttttgtct ggctgttccc acttactgca caacaaggag    420

ctcatggcct ccctggcaga aagcagcttt gatgtcatgc tgacggaccc tttccttcct    480

tgcagcccca tcgtggccca gtacctgtct ctgcccactg tattcttctt gcatgcactg    540

ccatgcagcc tggaatttga ggctacccag tgccccaacc cattctccta cgtgcccagg    600

cctctctcct ctcattcaga tcacatgacc ttcctgcagc gggtgaagaa catgctcatt    660

gccttttcac agaactttct gtgcgacgtg gtttattccc cgtatgcaac ccttgcctca    720

gaattccttc agagagaggt gactgtccag gacctattga gctctgcatc tgtctggctg    780

tttagaagtg actttgtgaa ggattaccct aggcccatca tgcccaatat ggtttttgtt    840

ggtggaatca actgccttca ccaaaatcca ctatcccagg aatttgaagc ctacattaat    900

gcttctggag aacatggaat tgtggttttc tctttgggat caatggtctc agaaattcca    960

gagaagaaag ctatggcaat tgctgatgct ttgggcaaaa tccctcagac agtcctgtgg   1020

cggtacactg gaacccgacc atcgaatctt gcgaacaaca cgatacttgt taagtggcta   1080

ccccaaaacg atctgcttgg tcacccgatg acccgtgcct ttatcaccca tgctggttcc   1140

catggtgttt atgaaagcat atgcaatggc gttcccatgg tgatgatgcc cttgtttggt   1200

gatcagatgg acaatgcaaa gcgcatggag actaagggag ctggagtgac cctgaatgtt   1260

ctggaaatga cttctgaaga tttagaaaat gctctaaaag cagtcatcaa tgacaaaagt   1320

tacaaggaga acatcatgcg cctctccagc cttcacaagg accgcccggt ggagccgctg   1380

gacctggccg tgttctgggt ggagtttgtg atgaggcaca agggcgcgcc acacctgcgc   1440

cccgcagccc acgacctcac ctggtaccag taccattcct tggacgtgat tggtttcctc   1500

ttggccgtcg tgctgacagt ggccttcatc acctttaaat gttgtgctta tggctaccgg   1560

aaatgcttgg ggaaaaaagg gcgagttaag aaagcccaca aatccaagac ccattgagaa   1620

gtgggtggga aataaggtaa aattttgaac cattccctag tcatttccaa acttgaaaac   1680

agaatcagtg ttaaattcat tttattctta ttaaggaaat actttgcata aattaatcag   1740

ccccagagtg ctttaaaaaa ttctcttaaa taaaaataat agactcgcta gtcagtaaag   1800

atatttgaat atgtatcgtg ccccctctgg tgtctttgat caggatgaca tgtgccattt   1860

ttcagaggac gtgcagacag gctggcattc tagattactt ttcttactct gaaacatggc   1920

ctgtttggga gtgcgggatt caaaggtggt cccacggctg cccctactgc aaatggcagt   1980

tttaatctta tcttttggct tctgcagatg gttgcaattg atccttaacc aataatggtc   2040

agtcctcatc tctgtcgtgc ttcataggtg ccaccttgtg tgtttaaaga agggaagctt   2100

tgtaccttta gagtgtaggt gaaatgaatg aatggcttgg agtgcactga gaacagcata   2160

tgatttcttg ctttggggaa aaagaatgat gctatgaaat tggtgggtgg tgtatttgag   2220

aagataatca ttgcttatgt caaatggagc tgaatttgat aaaaacccaa aatacagcta   2280

tgaagtgctg ggcaagttta ctttttttct gatgtttcct acaactaaaa ataaattaat   2340

aaatttatat aaattct                                                  2357


<210>  46
<211>  533
<212>  PRT
<213>  Homosapiens

<400>  46

Met Ala Val Glu Ser Gln Gly Gly Arg Pro Leu Val Leu Gly Leu Leu 
1               5                   10                  15      


Leu Cys Val Leu Gly Pro Val Val Ser His Ala Gly Lys Ile Leu Leu 
            20                  25                  30          


Ile Pro Val Asp Gly Ser His Trp Leu Ser Met Leu Gly Ala Ile Gln 
        35                  40                  45              


Gln Leu Gln Gln Arg Gly His Glu Ile Val Val Leu Ala Pro Asp Ala 
    50                  55                  60                  


Ser Leu Tyr Ile Arg Asp Gly Ala Phe Tyr Thr Leu Lys Thr Tyr Pro 
65                  70                  75                  80  


Val Pro Phe Gln Arg Glu Asp Val Lys Glu Ser Phe Val Ser Leu Gly 
                85                  90                  95      


His Asn Val Phe Glu Asn Asp Ser Phe Leu Gln Arg Val Ile Lys Thr 
            100                 105                 110         


Tyr Lys Lys Ile Lys Lys Asp Ser Ala Met Leu Leu Ser Gly Cys Ser 
        115                 120                 125             


His Leu Leu His Asn Lys Glu Leu Met Ala Ser Leu Ala Glu Ser Ser 
    130                 135                 140                 


Phe Asp Val Met Leu Thr Asp Pro Phe Leu Pro Cys Ser Pro Ile Val 
145                 150                 155                 160 


Ala Gln Tyr Leu Ser Leu Pro Thr Val Phe Phe Leu His Ala Leu Pro 
                165                 170                 175     


Cys Ser Leu Glu Phe Glu Ala Thr Gln Cys Pro Asn Pro Phe Ser Tyr 
            180                 185                 190         


Val Pro Arg Pro Leu Ser Ser His Ser Asp His Met Thr Phe Leu Gln 
        195                 200                 205             


Arg Val Lys Asn Met Leu Ile Ala Phe Ser Gln Asn Phe Leu Cys Asp 
    210                 215                 220                 


Val Val Tyr Ser Pro Tyr Ala Thr Leu Ala Ser Glu Phe Leu Gln Arg 
225                 230                 235                 240 


Glu Val Thr Val Gln Asp Leu Leu Ser Ser Ala Ser Val Trp Leu Phe 
                245                 250                 255     


Arg Ser Asp Phe Val Lys Asp Tyr Pro Arg Pro Ile Met Pro Asn Met 
            260                 265                 270         


Val Phe Val Gly Gly Ile Asn Cys Leu His Gln Asn Pro Leu Ser Gln 
        275                 280                 285             


Glu Phe Glu Ala Tyr Ile Asn Ala Ser Gly Glu His Gly Ile Val Val 
    290                 295                 300                 


Phe Ser Leu Gly Ser Met Val Ser Glu Ile Pro Glu Lys Lys Ala Met 
305                 310                 315                 320 


Ala Ile Ala Asp Ala Leu Gly Lys Ile Pro Gln Thr Val Leu Trp Arg 
                325                 330                 335     


Tyr Thr Gly Thr Arg Pro Ser Asn Leu Ala Asn Asn Thr Ile Leu Val 
            340                 345                 350         


Lys Trp Leu Pro Gln Asn Asp Leu Leu Gly His Pro Met Thr Arg Ala 
        355                 360                 365             


Phe Ile Thr His Ala Gly Ser His Gly Val Tyr Glu Ser Ile Cys Asn 
    370                 375                 380                 


Gly Val Pro Met Val Met Met Pro Leu Phe Gly Asp Gln Met Asp Asn 
385                 390                 395                 400 


Ala Lys Arg Met Glu Thr Lys Gly Ala Gly Val Thr Leu Asn Val Leu 
                405                 410                 415     


Glu Met Thr Ser Glu Asp Leu Glu Asn Ala Leu Lys Ala Val Ile Asn 
            420                 425                 430         


Asp Lys Ser Tyr Lys Glu Asn Ile Met Arg Leu Ser Ser Leu His Lys 
        435                 440                 445             


Asp Arg Pro Val Glu Pro Leu Asp Leu Ala Val Phe Trp Val Glu Phe 
    450                 455                 460                 


Val Met Arg His Lys Gly Ala Pro His Leu Arg Pro Ala Ala His Asp 
465                 470                 475                 480 


Leu Thr Trp Tyr Gln Tyr His Ser Leu Asp Val Ile Gly Phe Leu Leu 
                485                 490                 495     


Ala Val Val Leu Thr Val Ala Phe Ile Thr Phe Lys Cys Cys Ala Tyr 
            500                 505                 510         


Gly Tyr Arg Lys Cys Leu Gly Lys Lys Gly Arg Val Lys Lys Ala His 
        515                 520                 525             


Lys Ser Lys Thr His 
    530             


<210>  47
<211>  1279
<212>  DNA
<213>  Homosapiens

<400>  47
gccgtagtcc cagttgagaa gctgtgcccc cttgggtgtt ttggaggttc agggtgggtg     60

ctgaaaagcc ctgagggaga gcagaaggct cgggggcctg tctagggcat ggcatcccac    120

gtgggtgtca gcacggccgc agaagaacca cttctctggc ccacccatgc ctgctaggcc    180

atgcttcttc agaagtggcc acaactctcc tgacgtctcc agagccggtc attccaccca    240

gggggacttc agctgccact ggacacttca attgtacgct gcgaccagtt gccaggaagg    300

agagggctgg caagagagcc gcggcagccg tggcagggtg taggggacgg tggacggcca    360

gggccccccc ctctctctct ttctctctct ctctcttgct tggtttctgt aatgaggaag    420

ttctccgcag ctcagtttcc tttccctcac tgagcgcctg aaacaggaag tcagtcagtt    480

aagctggtgg cagcagccga ggccaccaag aggcaacggg cggcaggttg cagtggaggg    540

gcctccgctc ccctcggtgg tgtgtgggtc ctgggggtgc ctgccggccc ggccgaggag    600

gcccacgccc accatggtcc cctgctggaa ccatggcaac atcacccgct ccaaggcgga    660

ggagctgctt tccaggacag gcaaggacgg gagcttcctc gtgcgtgcca gcgagtccat    720

ctcccgggca tacgcgctct gcgtgctgta tcggaattgc gtttacactt acagaattct    780

gcccaatgaa gatgataaat tcactgttca ggcatccgaa ggcgtctcca tgaggttctt    840

caccaagctg gaccagctca tcgagtttta caagaaggaa aacatggggc tggtgaccca    900

tctgcaatac cctgtgccgc tggaggaaga ggacacaggc gacgaccctg aggaggacac    960

agaaagtgtc gtgtctccac ccgagctgcc cccaagaaac atcccgctga ctgccagctc   1020

ctgtgaggcc aaggaggttc ctttttcaaa cgagaatccc cgagcgaccg agaccagccg   1080

gccgagcctc tccgagacat tgttccagcg actgcaaagc atggacacca gtgggcttcc   1140

agaagagcat cttaaggcca tccaagatta tttaagcact cagctcgccc aggactctga   1200

atttgtgaag acagggtcca gcagtcttcc tcacctgaag aaactgacca cactgctctg   1260

caaggagctc tatgggtaa                                                1279


<210>  48
<211>  221
<212>  PRT
<213>  Homosapiens

<400>  48

Met Val Pro Cys Trp Asn His Gly Asn Ile Thr Arg Ser Lys Ala Glu 
1               5                   10                  15      


Glu Leu Leu Ser Arg Thr Gly Lys Asp Gly Ser Phe Leu Val Arg Ala 
            20                  25                  30          


Ser Glu Ser Ile Ser Arg Ala Tyr Ala Leu Cys Val Leu Tyr Arg Asn 
        35                  40                  45              


Cys Val Tyr Thr Tyr Arg Ile Leu Pro Asn Glu Asp Asp Lys Phe Thr 
    50                  55                  60                  


Val Gln Ala Ser Glu Gly Val Ser Met Arg Phe Phe Thr Lys Leu Asp 
65                  70                  75                  80  


Gln Leu Ile Glu Phe Tyr Lys Lys Glu Asn Met Gly Leu Val Thr His 
                85                  90                  95      


Leu Gln Tyr Pro Val Pro Leu Glu Glu Glu Asp Thr Gly Asp Asp Pro 
            100                 105                 110         


Glu Glu Asp Thr Glu Ser Val Val Ser Pro Pro Glu Leu Pro Pro Arg 
        115                 120                 125             


Asn Ile Pro Leu Thr Ala Ser Ser Cys Glu Ala Lys Glu Val Pro Phe 
    130                 135                 140                 


Ser Asn Glu Asn Pro Arg Ala Thr Glu Thr Ser Arg Pro Ser Leu Ser 
145                 150                 155                 160 


Glu Thr Leu Phe Gln Arg Leu Gln Ser Met Asp Thr Ser Gly Leu Pro 
                165                 170                 175     


Glu Glu His Leu Lys Ala Ile Gln Asp Tyr Leu Ser Thr Gln Leu Ala 
            180                 185                 190         


Gln Asp Ser Glu Phe Val Lys Thr Gly Ser Ser Ser Leu Pro His Leu 
        195                 200                 205             


Lys Lys Leu Thr Thr Leu Leu Cys Lys Glu Leu Tyr Gly 
    210                 215                 220     


<210>  49
<211>  5992
<212>  DNA
<213>  Homosapiens

<400>  49
ggcgacgtgt cggccatctt gtgttgttga ggctgaggac tgactggggt tctgagactc     60

cctgtcccgg accgcagatt atagtgggac cagtctcatt aggttgaatc tacagcctat    120

gttggtgtta acccaggtct cttagagcgt taaaaggatc tgaacaaagt ctgctcaaat    180

ctcctgctgt gaaccagcag aatttttgaa cagagaccac gtctccacct cctgggctcc    240

aacgattctc ccatcttggc ctcccaaagc gctggattta caggtttctt cacatataaa    300

aatctattgt aaaaatacgg aaaagaatgg cagcggaaac gcagacactg aactttgggc    360

ctgaatggct ccgagctctg tccagtggtg ggagtattac atcccctcct ctttctccag    420

cattgccgaa gtataaatta gcagattatc gttacggcag agaagaaatg ttagcacttt    480

tccttaaaga caacaagata ccttcagacc ttctggataa agaatttctg cctatcctcc    540

aggaggaacc ccttccacca ttggctctgg taccctttac agaagaagaa cagagaaact    600

tttccatgtc tgtaaatagt gctgctgtcc tgcgattgac aggacgagga ggaggaggaa    660

cagtggtggg ggctcctaga ggtcgaagtt cttcaagagg gcgaggcaga ggcagaggtg    720

aatgtggttt ctaccaaaga agttttgatg aagtagaggg tgtttttggt cgaggaggtg    780

gcagagaaat gcatagatcg cagagctggg aggaaagggg tgacagacgt tttgaaaaac    840

caggacgaaa agatgtaggg agaccaaatt ttgaggaagg tggaccaaca tcagtaggga    900

gaaagcatga atttatacgc tcagaaagtg aaaattggcg catctttaga gaggaacaaa    960

atggagaaga tgaagatgga ggttggcgac tagctggatc aaggagggat ggagagaggt   1020

ggcgacctca cagtcctgat ggccctcgtt ctgcaggctg gcgggaacac atggaacgac   1080

gtcggaggtt tgagtttgat tttcgagata gagatgatga acggggttac cgaagggttc   1140

gctctggcag tgggagcata gatgatgaca gggatagctt gcccgaatgg tgcttagagg   1200

atgctgaaga agaaatgggt acatttgact catctggagc attcctttct ctaaaaaaag   1260

tacagaaaga gcctattcca gaagagcagg agatggactt ccggcctgtg gacgaagggg   1320

aggagtgctc tgactctgag ggtagccata atgaagaggc caaagaaccc gataagacaa   1380

ataagaaaga aggagagaaa acagatagag taggagttga agctagtgag gaaactcccc   1440

agacctcatc atcatctgct agaccaggta ctccttcaga ccatcagtct caggaagcat   1500

cacagtttga gaggaaagat gaaccaaaaa ctgagcaaac ggaaaaagct gaagaggaga   1560

ctcggatgga aaatagtcta ccagccaaag tgcccagcag aggggatgaa atggttgctg   1620

atgtccagca gcccctgtcg cagattcctt cagatacagc ctctcctctt ctcatacttc   1680

cacctcctgt tcccaatcct agtcctactc tccggccagt tgaaacacca gttgtaggtg   1740

ctcctggtat gggcagtgtt tccacagaac ctgatgatga agaaggtctc aaacatttgg   1800

agcagcaagc tgagaaaatg gtggcttatc tccaagacag tgcactagat gatgaaagat   1860

tggcatcaaa actgcaagag cacagagcta aaggagtgtc gattccattg atgcatgaag   1920

caatgcagaa gtggtattac aaagatcctc agggagaaat tcaaggtccc ttcaataatc   1980

aggagatggc agaatggttt caggcgggct attttactat gtctttattg gtgaagagag   2040

cgtgtgatga aagcttccaa cctcttggcg atatcatgaa aatgtgggga agggttccct   2100

tttctccagg tccagctccc cctcctcata tgggagagct ggaccaggaa cgactgacca   2160

ggcagcaaga actcacagcc ttataccaga tgcagcacct gcagtaccag cagtttttaa   2220

tacaacaaca atatgcacag gttttggccc aacagcagaa agcagcactg tcttcccagc   2280

agcagcagca gttggcactt cttcttcaac agtttcagac cttgaagatg agaatatctg   2340

atcagaacat cattccctca gtaactaggt ctgtgtccgt gccagatact ggctctatct   2400

gggagcttca gccaacagct tcacagccta cagtttggga aggtggtagt gtatgggatc   2460

ttcctctgga caccacgaca ccaggccctg ccctggaaca gcttcagcag ctagagaagg   2520

ccaaagctgc aaagctagag caagagagaa gagaggcaga aatgagggca aaacgggaag   2580

aggaagagcg aaagaggcag gaagaactcc gaagacaaca ggaggaaatt cttcggcgac   2640

agcaggaaga agaaaggaaa aggcgagagg aagaagaact tgcccgaagg aaacaggaag   2700

aggctctgcg tcgccagcgg gagcaagaaa ttgcattaag gcgacagcga gaagaggaag   2760

aaagacagca gcaagaagaa gctcttagaa gactggaaga gaggagaaga gaagaggaag   2820

aaaggcggaa gcaggaagaa ttgttacgca aacaggaaga ggaggctgca aaatgggccc   2880

gggaagaaga agaagcccag cgtcgattag aggagaaccg gctgcggatg gaagaggagg   2940

cagccagact ccggcatgag gaagaagaac ggaagagaaa ggagctggag gtccagcggc   3000

agaaggagtt aatgcgccag aggcagcagc agcaagaggc tctccggagg ttgcagcagc   3060

agcagcagca acaacagctg gcgcagatga agcttccttc ttcttcaacg tggggccagc   3120

agtccaatac aacagcatgt cagtcccagg ccacgctgtc gttggctgaa atccaaaaac   3180

tagaggaaga acgagaacgg cagcttcgag aagagcaaag gcgccagcag agggagttga   3240

tgaaagctct tcagcagcag cagcaacagc aacagcagaa actctcaggt tgggggaatg   3300

tcagcaaacc ttcaggtacc acgaaatctc ttctggagat ccagcaggaa gaggccaggc   3360

aaatgcaaaa gcagcagcag cagcagcagc aacaccagca accaaacaga gctcgtaaca   3420

atacgcattc caacctgcac accagcattg ggaattctgt ttggggctct ataaatactg   3480

gtcctcctaa ccagtgggca tctgacctag tcagtagtat ttggagtaat gctgacacta   3540

aaaactccaa catgggattc tgggatgatg cagtgaaaga ggtgggacct aggaattcaa   3600

caaataaaaa taaaaacaac gccagtctca gtaaatctgt aggtgtgtct aaccggcaga   3660

ataagaaagt agaagaagaa gaaaagttgc tgaagctctt tcagggagta aataaagccc   3720

aagatggatt tacgcagtgg tgtgaacaga tgcttcatgc ccttaatacg gcaaataact   3780

tggatgttcc cacatttgtt tctttcctga aagaagtaga atctccttat gaggtccatg   3840

attatatcag ggcctattta ggagatactt ctgaggccaa ggagtttgcc aagcagttcc   3900

ttgagcgccg tgccaaacag aaagccaacc agcagcgtca gcagcagcag ctgccacagc   3960

agcagcagca gcagccgcca cagcagccgc cacagcagcc acaacagcag gactctgtgt   4020

gggggatgaa ccacagtaca ctccattcag tatttcagac caatcaaagc aacaaccaac   4080

aatccaattt tgaggctgtg cagagtggca agaagaagaa aaagcagaag atggtccgag   4140

cagatcccag tttattagga ttttcagtca atgcatcatc ggagcgactc aacatgggtg   4200

aaatcgagac gttggatgac tactgagcac ctgccagtgg actggccatc cctctcctgt   4260

ctgccgacta tggagtctcc acctttggac acaacactta ctcaccattt actctttatc   4320

actctgcaac aaatcacaga accgatcatc tcaggctttt tcttctggcc ctttgtgtcc   4380

aagattcttt aatccatttt tgttggtgaa catctcagac tatagataag tggactggac   4440

cctgtgtctt gggggtggca gttgggatta ctccccaaca aggctgattt taggcagcat   4500

gtgttcactg tgctgtgatt tcatctactg tctcccagaa agtgtgttgg gatcggccat   4560

tagcagcttg ctttctcttg tcactttttt tcttctattt tgttttttct tcttcttttt   4620

ccccccatca gggcaaatgg tctaactggt gcaatcatga agagagttaa tggttaacag   4680

acattggcca ataacaaaac accccatgga ctgtgactcg agtatccaac aggcagtcag   4740

agctctcccg gtctgaaagt tgcattgcca ctgctaactt tgggattgca tcagagaggc   4800

cctgagtggg gttgagatga ggttggtttg gtttgatgtt acacactcct cacctgttct   4860

ttctgagtgt cctttctctg aaaggattta tgtttttctt cgttagatag tgacttctga   4920

gcaagctgat ctcccctggc atgctccaac ctgattggac aaaggaagct ctatggcctg   4980

ggagagagac tattcttaat ttttctttct tacaaaaact gatttttccc ataaatattt   5040

ttacttcaga ggactaggac cattttgttt tgggcccttc tgctgaaaat ttgtctcgtt   5100

taagaggcag ctagaatctt taccatatgt atgaatttgt ataatttcat ttttggatag   5160

ggataaactt ttgcttctga taaaagcctg gaatttcatc tggtcctcag agcattgcgt   5220

gtgtgtcttg ctgtagcccg gaaaaggttt tgtgtaaaga ttctgggatg gcaagttgtt   5280

tgccttttct gaaaagagaa catacagaac ctgtccatct ttaagacctt catccatgga   5340

atctactata caggaggatg cagtgggctg gaggggatgg gcgaaaatgg gagcaggaag   5400

cctggcctgg cttctggtca tggcctccta aaaccttaaa cttcaagtag aaatgtactc   5460

aagccctatt tataaacaaa tacttttcct gcctccacca aacccctaca gaacatcacc   5520

tggaattgcc actcacactg ggttggagtc attgggcagc tgtgcctgtg cgagaggtgc   5580

tgtggtctgg gcagcccctg gaaaagcacc tttgctgcct gtcattgttg cctgaagaag   5640

gctggagttg ctctgagagc agtttgggtt tggagtatta tatttggctt ctatttttat   5700

tattttggat caccattctc cctatccctt cttgcctccc tcccttctaa acatgtgtaa   5760

taactataca gagactgcta caaaattgta tatagttttt ggatcaaata gcatgagggg   5820

agaggaaacc attaaaagtt ggggctccta ctctcctttg ctttgtaaat tcaaaagttg   5880

ggggtgggta agagggatag ttaaaatgtt tacaaaactt taggctccct cggaactttt   5940

gccagtgtgg aggaaaataa aaaagaactt aaataaaatc tgattgtatt ct           5992


<210>  50
<211>  1299
<212>  PRT
<213>  Homosapiens

<400>  50

Met Ala Ala Glu Thr Gln Thr Leu Asn Phe Gly Pro Glu Trp Leu Arg 
1               5                   10                  15      


Ala Leu Ser Ser Gly Gly Ser Ile Thr Ser Pro Pro Leu Ser Pro Ala 
            20                  25                  30          


Leu Pro Lys Tyr Lys Leu Ala Asp Tyr Arg Tyr Gly Arg Glu Glu Met 
        35                  40                  45              


Leu Ala Leu Phe Leu Lys Asp Asn Lys Ile Pro Ser Asp Leu Leu Asp 
    50                  55                  60                  


Lys Glu Phe Leu Pro Ile Leu Gln Glu Glu Pro Leu Pro Pro Leu Ala 
65                  70                  75                  80  


Leu Val Pro Phe Thr Glu Glu Glu Gln Arg Asn Phe Ser Met Ser Val 
                85                  90                  95      


Asn Ser Ala Ala Val Leu Arg Leu Thr Gly Arg Gly Gly Gly Gly Thr 
            100                 105                 110         


Val Val Gly Ala Pro Arg Gly Arg Ser Ser Ser Arg Gly Arg Gly Arg 
        115                 120                 125             


Gly Arg Gly Glu Cys Gly Phe Tyr Gln Arg Ser Phe Asp Glu Val Glu 
    130                 135                 140                 


Gly Val Phe Gly Arg Gly Gly Gly Arg Glu Met His Arg Ser Gln Ser 
145                 150                 155                 160 


Trp Glu Glu Arg Gly Asp Arg Arg Phe Glu Lys Pro Gly Arg Lys Asp 
                165                 170                 175     


Val Gly Arg Pro Asn Phe Glu Glu Gly Gly Pro Thr Ser Val Gly Arg 
            180                 185                 190         


Lys His Glu Phe Ile Arg Ser Glu Ser Glu Asn Trp Arg Ile Phe Arg 
        195                 200                 205             


Glu Glu Gln Asn Gly Glu Asp Glu Asp Gly Gly Trp Arg Leu Ala Gly 
    210                 215                 220                 


Ser Arg Arg Asp Gly Glu Arg Trp Arg Pro His Ser Pro Asp Gly Pro 
225                 230                 235                 240 


Arg Ser Ala Gly Trp Arg Glu His Met Glu Arg Arg Arg Arg Phe Glu 
                245                 250                 255     


Phe Asp Phe Arg Asp Arg Asp Asp Glu Arg Gly Tyr Arg Arg Val Arg 
            260                 265                 270         


Ser Gly Ser Gly Ser Ile Asp Asp Asp Arg Asp Ser Leu Pro Glu Trp 
        275                 280                 285             


Cys Leu Glu Asp Ala Glu Glu Glu Met Gly Thr Phe Asp Ser Ser Gly 
    290                 295                 300                 


Ala Phe Leu Ser Leu Lys Lys Val Gln Lys Glu Pro Ile Pro Glu Glu 
305                 310                 315                 320 


Gln Glu Met Asp Phe Arg Pro Val Asp Glu Gly Glu Glu Cys Ser Asp 
                325                 330                 335     


Ser Glu Gly Ser His Asn Glu Glu Ala Lys Glu Pro Asp Lys Thr Asn 
            340                 345                 350         


Lys Lys Glu Gly Glu Lys Thr Asp Arg Val Gly Val Glu Ala Ser Glu 
        355                 360                 365             


Glu Thr Pro Gln Thr Ser Ser Ser Ser Ala Arg Pro Gly Thr Pro Ser 
    370                 375                 380                 


Asp His Gln Ser Gln Glu Ala Ser Gln Phe Glu Arg Lys Asp Glu Pro 
385                 390                 395                 400 


Lys Thr Glu Gln Thr Glu Lys Ala Glu Glu Glu Thr Arg Met Glu Asn 
                405                 410                 415     


Ser Leu Pro Ala Lys Val Pro Ser Arg Gly Asp Glu Met Val Ala Asp 
            420                 425                 430         


Val Gln Gln Pro Leu Ser Gln Ile Pro Ser Asp Thr Ala Ser Pro Leu 
        435                 440                 445             


Leu Ile Leu Pro Pro Pro Val Pro Asn Pro Ser Pro Thr Leu Arg Pro 
    450                 455                 460                 


Val Glu Thr Pro Val Val Gly Ala Pro Gly Met Gly Ser Val Ser Thr 
465                 470                 475                 480 


Glu Pro Asp Asp Glu Glu Gly Leu Lys His Leu Glu Gln Gln Ala Glu 
                485                 490                 495     


Lys Met Val Ala Tyr Leu Gln Asp Ser Ala Leu Asp Asp Glu Arg Leu 
            500                 505                 510         


Ala Ser Lys Leu Gln Glu His Arg Ala Lys Gly Val Ser Ile Pro Leu 
        515                 520                 525             


Met His Glu Ala Met Gln Lys Trp Tyr Tyr Lys Asp Pro Gln Gly Glu 
    530                 535                 540                 


Ile Gln Gly Pro Phe Asn Asn Gln Glu Met Ala Glu Trp Phe Gln Ala 
545                 550                 555                 560 


Gly Tyr Phe Thr Met Ser Leu Leu Val Lys Arg Ala Cys Asp Glu Ser 
                565                 570                 575     


Phe Gln Pro Leu Gly Asp Ile Met Lys Met Trp Gly Arg Val Pro Phe 
            580                 585                 590         


Ser Pro Gly Pro Ala Pro Pro Pro His Met Gly Glu Leu Asp Gln Glu 
        595                 600                 605             


Arg Leu Thr Arg Gln Gln Glu Leu Thr Ala Leu Tyr Gln Met Gln His 
    610                 615                 620                 


Leu Gln Tyr Gln Gln Phe Leu Ile Gln Gln Gln Tyr Ala Gln Val Leu 
625                 630                 635                 640 


Ala Gln Gln Gln Lys Ala Ala Leu Ser Ser Gln Gln Gln Gln Gln Leu 
                645                 650                 655     


Ala Leu Leu Leu Gln Gln Phe Gln Thr Leu Lys Met Arg Ile Ser Asp 
            660                 665                 670         


Gln Asn Ile Ile Pro Ser Val Thr Arg Ser Val Ser Val Pro Asp Thr 
        675                 680                 685             


Gly Ser Ile Trp Glu Leu Gln Pro Thr Ala Ser Gln Pro Thr Val Trp 
    690                 695                 700                 


Glu Gly Gly Ser Val Trp Asp Leu Pro Leu Asp Thr Thr Thr Pro Gly 
705                 710                 715                 720 


Pro Ala Leu Glu Gln Leu Gln Gln Leu Glu Lys Ala Lys Ala Ala Lys 
                725                 730                 735     


Leu Glu Gln Glu Arg Arg Glu Ala Glu Met Arg Ala Lys Arg Glu Glu 
            740                 745                 750         


Glu Glu Arg Lys Arg Gln Glu Glu Leu Arg Arg Gln Gln Glu Glu Ile 
        755                 760                 765             


Leu Arg Arg Gln Gln Glu Glu Glu Arg Lys Arg Arg Glu Glu Glu Glu 
    770                 775                 780                 


Leu Ala Arg Arg Lys Gln Glu Glu Ala Leu Arg Arg Gln Arg Glu Gln 
785                 790                 795                 800 


Glu Ile Ala Leu Arg Arg Gln Arg Glu Glu Glu Glu Arg Gln Gln Gln 
                805                 810                 815     


Glu Glu Ala Leu Arg Arg Leu Glu Glu Arg Arg Arg Glu Glu Glu Glu 
            820                 825                 830         


Arg Arg Lys Gln Glu Glu Leu Leu Arg Lys Gln Glu Glu Glu Ala Ala 
        835                 840                 845             


Lys Trp Ala Arg Glu Glu Glu Glu Ala Gln Arg Arg Leu Glu Glu Asn 
    850                 855                 860                 


Arg Leu Arg Met Glu Glu Glu Ala Ala Arg Leu Arg His Glu Glu Glu 
865                 870                 875                 880 


Glu Arg Lys Arg Lys Glu Leu Glu Val Gln Arg Gln Lys Glu Leu Met 
                885                 890                 895     


Arg Gln Arg Gln Gln Gln Gln Glu Ala Leu Arg Arg Leu Gln Gln Gln 
            900                 905                 910         


Gln Gln Gln Gln Gln Leu Ala Gln Met Lys Leu Pro Ser Ser Ser Thr 
        915                 920                 925             


Trp Gly Gln Gln Ser Asn Thr Thr Ala Cys Gln Ser Gln Ala Thr Leu 
    930                 935                 940                 


Ser Leu Ala Glu Ile Gln Lys Leu Glu Glu Glu Arg Glu Arg Gln Leu 
945                 950                 955                 960 


Arg Glu Glu Gln Arg Arg Gln Gln Arg Glu Leu Met Lys Ala Leu Gln 
                965                 970                 975     


Gln Gln Gln Gln Gln Gln Gln Gln Lys Leu Ser Gly Trp Gly Asn Val 
            980                 985                 990         


Ser Lys Pro Ser Gly Thr Thr Lys  Ser Leu Leu Glu Ile  Gln Gln Glu 
        995                 1000                 1005             


Glu Ala  Arg Gln Met Gln Lys  Gln Gln Gln Gln Gln  Gln Gln His 
    1010                 1015                 1020             


Gln Gln  Pro Asn Arg Ala Arg  Asn Asn Thr His Ser  Asn Leu His 
    1025                 1030                 1035             


Thr Ser  Ile Gly Asn Ser Val  Trp Gly Ser Ile Asn  Thr Gly Pro 
    1040                 1045                 1050             


Pro Asn  Gln Trp Ala Ser Asp  Leu Val Ser Ser Ile  Trp Ser Asn 
    1055                 1060                 1065             


Ala Asp  Thr Lys Asn Ser Asn  Met Gly Phe Trp Asp  Asp Ala Val 
    1070                 1075                 1080             


Lys Glu  Val Gly Pro Arg Asn  Ser Thr Asn Lys Asn  Lys Asn Asn 
    1085                 1090                 1095             


Ala Ser  Leu Ser Lys Ser Val  Gly Val Ser Asn Arg  Gln Asn Lys 
    1100                 1105                 1110             


Lys Val  Glu Glu Glu Glu Lys  Leu Leu Lys Leu Phe  Gln Gly Val 
    1115                 1120                 1125             


Asn Lys  Ala Gln Asp Gly Phe  Thr Gln Trp Cys Glu  Gln Met Leu 
    1130                 1135                 1140             


His Ala  Leu Asn Thr Ala Asn  Asn Leu Asp Val Pro  Thr Phe Val 
    1145                 1150                 1155             


Ser Phe  Leu Lys Glu Val Glu  Ser Pro Tyr Glu Val  His Asp Tyr 
    1160                 1165                 1170             


Ile Arg  Ala Tyr Leu Gly Asp  Thr Ser Glu Ala Lys  Glu Phe Ala 
    1175                 1180                 1185             


Lys Gln  Phe Leu Glu Arg Arg  Ala Lys Gln Lys Ala  Asn Gln Gln 
    1190                 1195                 1200             


Arg Gln  Gln Gln Gln Leu Pro  Gln Gln Gln Gln Gln  Gln Pro Pro 
    1205                 1210                 1215             


Gln Gln  Pro Pro Gln Gln Pro  Gln Gln Gln Asp Ser  Val Trp Gly 
    1220                 1225                 1230             


Met Asn  His Ser Thr Leu His  Ser Val Phe Gln Thr  Asn Gln Ser 
    1235                 1240                 1245             


Asn Asn  Gln Gln Ser Asn Phe  Glu Ala Val Gln Ser  Gly Lys Lys 
    1250                 1255                 1260             


Lys Lys  Lys Gln Lys Met Val  Arg Ala Asp Pro Ser  Leu Leu Gly 
    1265                 1270                 1275             


Phe Ser  Val Asn Ala Ser Ser  Glu Arg Leu Asn Met  Gly Glu Ile 
    1280                 1285                 1290             


Glu Thr  Leu Asp Asp Tyr 
    1295                 


<210>  51
<211>  7943
<212>  DNA
<213>  Homosapiens

<400>  51
ggcgacgtgt cggccatctt gtgttgttga ggctgaggac tgactggggt tctgagactc     60

cctgtcccgg accgcagatt atagtgggac cagtctcatt aggttgaatc tacagcctat    120

gttggtgtta acccaggtct cttagagcgt taaaaggatc tgaacaaagt ctgctcaaat    180

ctcctgctgt gaaccagcag aatttttgaa cagagaccac gtctccacct cctgggctcc    240

aacgattctc ccatcttggc ctcccaaagc gctggattta caggtttctt cacatataaa    300

aatctattgt aaaaatacgg aaaagaatgg cagcggaaac gcagacactg aactttgggc    360

ctgaatggct ccgagctctg tccagtggtg ggagtattac atcccctcct ctttctccag    420

cattgccgaa gtataaatta gcagattatc gttacggcag agaagaaatg ttagcacttt    480

tccttaaaga caacaagata ccttcagacc ttctggataa agaatttctg cctatcctcc    540

aggaggaacc ccttccacca ttggctctgg taccctttac agaagaagaa cagagaaact    600

tttccatgtc tgtaaatagt gctgctgtcc tgcgattgac aggacgagga ggaggaggaa    660

cagtggtggg ggctcctaga ggtcgaagtt cttcaagagg gcgaggcaga ggcagaggtg    720

aatgtggttt ctaccaaaga agttttgatg aagtagaggg tgtttttggt cgaggaggtg    780

gcagagaaat gcatagatcg cagagctggg aggaaagggg tgacagacgt tttgaaaaac    840

caggacgaaa agatgtaggg agaccaaatt ttgaggaagg tggaccaaca tcagtaggga    900

gaaagcatga atttatacgc tcagaaagtg aaaattggcg catctttaga gaggaacaaa    960

atggagaaga tgaagatgga ggttggcgac tagctggatc aaggagggat ggagagaggt   1020

ggcgacctca cagtcctgat ggccctcgtt ctgcaggctg gcgggaacac atggaacgac   1080

gtcggaggtt tgagtttgat tttcgagata gagatgatga acggggttac cgaagggttc   1140

gctctggcag tgggagcata gatgatgaca gggatagctt gcccgaatgg tgcttagagg   1200

atgctgaaga agaaatgggt acatttgact catctggagc attcctttct ctaaaaaaag   1260

tacagaaaga gcctattcca gaagagcagg agatggactt ccggcctgtg gacgaagggg   1320

aggagtgctc tgactctgag ggtagccata atgaagaggc caaagaaccc gataagacaa   1380

ataagaaaga aggagagaaa acagatagag taggagttga agctagtgag gaaactcccc   1440

agacctcatc atcatctgct agaccaggta ctccttcaga ccatcagtct caggaagcat   1500

cacagtttga gaggaaagat gaaccaaaaa ctgagcaaac ggaaaaagct gaagaggaga   1560

ctcggatgga aaatagtcta ccagccaaag tgcccagcag aggggatgaa atggttgctg   1620

atgtccagca gcccctgtcg cagattcctt cagatacagc ctctcctctt ctcatacttc   1680

cacctcctgt tcccaatcct agtcctactc tccggccagt tgaaacacca gttgtaggtg   1740

ctcctggtat gggcagtgtt tccacagaac ctgatgatga agaaggtctc aaacatttgg   1800

agcagcaagc tgagaaaatg gtggcttatc tccaagacag tgcactagat gatgaaagat   1860

tggcatcaaa actgcaagag cacagagcta aaggagtgtc gattccattg atgcatgaag   1920

caatgcagaa gtggtattac aaagatcctc agggagaaat tcaaggtccc ttcaataatc   1980

aggagatggc agaatggttt caggcgggct attttactat gtctttattg gtgaagagag   2040

cgtgtgatga aagcttccaa cctcttggcg atatcatgaa aatgtgggga agggttccct   2100

tttctccagg tccagctccc cctcctcata tgggagagct ggaccaggaa cgactgacca   2160

ggcagcaaga actcacagcc ttataccaga tgcagcacct gcagtaccag cagtttttaa   2220

tacaacaaca atatgcacag gttttggccc aacagcagaa agcagcactg tcttcccagc   2280

agcagcagca gttggcactt cttcttcaac agtttcagac cttgaagatg agaatatctg   2340

atcagaacat cattccctca gtaactaggt ctgtgtccgt gccagatact ggctctatct   2400

gggagcttca gccaacagct tcacagccta cagtttggga aggtggtagt gtatgggatc   2460

ttcctctgga caccacgaca ccaggccctg ccctggaaca gcttcagcag ctagagaagg   2520

ccaaagctgc aaagctagag caagagagaa gagaggcaga aatgagggca aaacgggaag   2580

aggaagagcg aaagaggcag gaagaactcc gaagacaaca ggaggaaatt cttcggcgac   2640

agcaggaaga agaaaggaaa aggcgagagg aagaagaact tgcccgaagg aaacaggaag   2700

aggctctgcg tcgccagcgg gagcaagaaa ttgcattaag gcgacagcga gaagaggaag   2760

aaagacagca gcaagaagaa gctcttagaa gactggaaga gaggagaaga gaagaggaag   2820

aaaggcggaa gcaggaagaa ttgttacgca aacaggaaga ggaggctgca aaatgggccc   2880

gggaagaaga agaagcccag cgtcgattag aggagaaccg gctgcggatg gaagaggagg   2940

cagccagact ccggcatgag gaagaagaac ggaagagaaa ggagctggag gtccagcggc   3000

agaaggagtt aatgcgccag aggcagcagc agcaagaggc tctccggagg ttgcagcagc   3060

agcagcagca acaacagctg gcgcagatga agcttccttc ttcttcaacg tggggccagc   3120

agtccaatac aacagcatgt cagtcccagg ccacgctgtc gttggctgaa atccaaaaac   3180

tagaggaaga acgagaacgg cagcttcgag aagagcaaag gcgccagcag agggagttga   3240

tgaaagctct tcagcagcag cagcaacagc aacagcagaa actctcaggt tgggggaatg   3300

tcagcaaacc ttcaggtacc acgaaatctc ttctggagat ccagcaggaa gaggccaggc   3360

aaatgcaaaa gcagcagcag cagcagcagc aacaccagca accaaacaga gctcgtaaca   3420

atacgcattc caacctgcac accagcattg ggaattctgt ttggggctct ataaatactg   3480

gtcctcctaa ccagtgggca tctgacctag tcagtagtat ttggagtaat gctgacacta   3540

aaaactccaa catgggattc tgggatgatg cagtgaaaga ggtgggacct aggaattcaa   3600

caaataaaaa taaaaacaac gccagtctca gtaaatctgt aggtgtgtct aaccggcaga   3660

ataagaaagt agaagaagaa gaaaagttgc tgaagctctt tcagggagta aataaagccc   3720

aagatggatt tacgcagtgg tgtgaacaga tgcttcatgc ccttaatacg gcaaataact   3780

tggatgttcc cacatttgtt tctttcctga aagaagtaga atctccttat gaggtccatg   3840

attatatcag ggcctattta ggagatactt ctgaggccaa ggagtttgcc aagcagttcc   3900

ttgagcgccg tgccaaacag aaagccaacc agcagcgtca gcagcagcag ctgccacagc   3960

agcagcagca gcagccgcca cagcagccgc cacagcagcc acaacagcag gactctgtgt   4020

gggggatgaa ccacagtaca ctccattcag tatttcagac caatcaaagc aacaaccaac   4080

aatccaattt tgaggctgtg cagagtggca agaagaagaa aaagcagaag atggtccgag   4140

cagatcccag tttattagga ttttcagtca atgcatcatc ggagcgactc aacatgggtg   4200

aaatcgagac gttggatgac tactgagcac ctgccagtgg actggccatc cctctcctgt   4260

ctgccgacta tggagtctcc acctttggac acaacactta ctcaccattt actctttatc   4320

actctgcaac aaatcacaga accgatcatc tcaggctttt tcttctggcc ctttgtgtcc   4380

aagattcttt aatccatttt tgttggtgaa catctcagac tatagataag tggactggac   4440

cctgtgtctt gggggtggca gttgggatta ctccccaaca aggctgattt taggcagcat   4500

gtgttcactg tgctgtgatt tcatctactg tctcccagaa agtgtgttgg gatcggccat   4560

tagcagcttg ctttctcttg tcactttttt tcttctattt tgttttttct tcttcttttt   4620

ccccccatca gggcaaatgg tctaactggt gcaatcatga agagagttaa tggttaacag   4680

acattggcca ataacaaaac accccatgga ctgtgactcg agtatccaac aggcagtcag   4740

agctctcccg gtctgaaagt tgcattgcca ctgctaactt tgggattgca tcagagaggc   4800

cctgagtggg gttgagatga ggttggtttg gtttgatgtt acacactcct cacctgttct   4860

ttctgagtgt cctttctctg aaaggattta tgtttttctt cgttagatag tgacttctga   4920

gcaagctgat ctcccctggc atgctccaac ctgattggac aaaggaagct ctatggcctg   4980

ggagagagac tattcttaat ttttctttct tacaaaaact gatttttccc ataaatattt   5040

ttacttcaga ggactaggac cattttgttt tgggcccttc tgctgaaaat ttgtctcgtt   5100

taagaggcag ctagaatctt taccatatgt atgaatttgt ataatttcat ttttggatag   5160

ggataaactt ttgcttctga taaaagcctg gaatttcatc tggtcctcag agcattgcgt   5220

gtgtgtcttg ctgtagcccg gaaaaggttt tgtgtaaaga ttctgggatg gcaagttgtt   5280

tgccttttct gaaaagagaa catacagaac ctgtccatct ttaagacctt catccatgga   5340

atctactata caggaggatg cagtgggctg gaggggatgg gcgaaaatgg gagcaggaag   5400

cctggcctgg cttctggtca tggcctccta aaaccttaaa cttcaagtag aaatgtactc   5460

aagccctatt tataaacaaa tacttttcct gcctccacca aacccctaca gaacatcacc   5520

tggaattgcc actcacactg ggttggagtc attgggcagc tgtgcctgtg cgagaggtgc   5580

tgtggtctgg gcagcccctg gaaaagcacc tttgctgcct gtcattgttg cctgaagaag   5640

gctggagttg ctctgagagc agtttgggtt tggagtatta tatttggctt ctatttttat   5700

tattttggat caccattctc cctatccctt cttgcctccc tcccttctaa acatgtgtaa   5760

taactataca gagactgcta caaaattgta tatagttttt ggatcaaata gcatgagggg   5820

agaggaaacc attaaaagtt ggggctccta ctctcctttg ctttgtaaat tcaaaagttg   5880

ggggtgggta agagggatag ttaaaatgtt tacaaaactt taggctccct cggaactttt   5940

gccagtgtgg aggaaaataa aaaagaactt aaataaaatc tgattgtatt ctatctgagt   6000

gcacctcttg tactcacctt tatggaggct gagttctgca ctaaactgtt cctcttggta   6060

ccatggaaaa gctccaagca cccaagacat ggaggcagcc atggcttctt tctctgccag   6120

accacgtagc actggctggt tctgtatttg agaatgtaga ggtcaaggca gatgtcggta   6180

agtttgacca aatatctttt ctctttttga ctctcccttt ctgctaacat gtggatcagc   6240

tcctgccctc ataccgcaga cacacccact ctgaacacac ccctccagag cttgcccaca   6300

ccttcccaac tagactctgt gtgtgtattc aggaaaaatg aaaataaatt tttaaaaatt   6360

gggagtggaa tgggcagatt agggggaaca aagtcatttt ggtcatggaa catccatttg   6420

cttaaccaag gagacttgct tctatctgag gaatttccca cttagtagaa agaaacactc   6480

ttccctggga atgtttgttt ctgtctctct caatgctact ctctttcata ttctcatttg   6540

ctcacccttt cacttagagc caccgttttc tcatcccatt ctatgaactt atttccaaat   6600

tctcctaact attcctgagt tttgaagtat ttgttttgta ccctctctgc ttccggtttt   6660

ttgtttggtt ggcttttttg gagatagggt cttgtgatgt tgcccacact ggtctcgagc   6720

ccctgggctc aagtgatcct cccgcctcag cctcctaaat atctaggact acaggtgtgt   6780

gccaccatgc ccagctccag ttttgttggt tgatttgttt aaattcagag atttaaaaac   6840

atcccagaca agacagtttg attatggaga ctgtccccaa gcagattggt gtgctggtgg   6900

ctgctgtgca taacagattc cctccagatt ggcttacaac agctacttca ttctgtgggt   6960

caggaatttg gatagggctc agctgggtgg tggttctcct ggggtattct ttggttgtgg   7020

tcagatgtct tccagggcat cattcctatg aaggcttaat gaattaggca agctgtccaa   7080

gatggctcac tcgtgtaatg acagttgacg ttggctgtag gctgggaact cagctgggtt   7140

gatgactgga ggagcttatg tgtgtcgtct ccggaatggc agcttcagag gagttgaact   7200

taagtggtga ttggcttccc ccagagaacc aggcagaagc tgtgttacct ttttgagctc   7260

ttagctcagg agtcacatag agtcacttct gtgacactgt gttgcatcaa agtagtcaca   7320

aacccactca gattcaagag aagggagcat ggccctctcc ctgcaacccc ctcccccccc   7380

gccttgatga aaggagtgac aaggtcacat tggagaagag cttgtggggt gggagatatt   7440

atagccattt ttgggaaata tctgcataaa atgagtttat gcatacatga aggactttat   7500

tttcattggc tttaagttga gggtttttgt ttttgttttt gtattggaga tgggttctta   7560

ctatgttgcc caggctggtc tcaaacccct gggctcaagt gatcctgttg cctcagcctc   7620

ccaagtagct gggactacag ctatgtgcca gtgcacccag cttgtttttt ttaaatttta   7680

ggatagataa tggtacttct ggctttattt aaataatttt tttagggaaa ccattgtatt   7740

tatacatgca tatattttta tatatacaaa tatgtatata aaagtatatg ttttacattt   7800

tcaatatata tataatatat acatatatgt tatatacgta tatatattgc accctacttt   7860

aaaattgact gataacaaaa ttggtaattt tgtataaaat gcccaactgt gcattattaa   7920

taaaagtatg tgaatgactc taa                                           7943


<210>  52
<211>  1299
<212>  PRT
<213>  Homosapiens

<400>  52

Met Ala Ala Glu Thr Gln Thr Leu Asn Phe Gly Pro Glu Trp Leu Arg 
1               5                   10                  15      


Ala Leu Ser Ser Gly Gly Ser Ile Thr Ser Pro Pro Leu Ser Pro Ala 
            20                  25                  30          


Leu Pro Lys Tyr Lys Leu Ala Asp Tyr Arg Tyr Gly Arg Glu Glu Met 
        35                  40                  45              


Leu Ala Leu Phe Leu Lys Asp Asn Lys Ile Pro Ser Asp Leu Leu Asp 
    50                  55                  60                  


Lys Glu Phe Leu Pro Ile Leu Gln Glu Glu Pro Leu Pro Pro Leu Ala 
65                  70                  75                  80  


Leu Val Pro Phe Thr Glu Glu Glu Gln Arg Asn Phe Ser Met Ser Val 
                85                  90                  95      


Asn Ser Ala Ala Val Leu Arg Leu Thr Gly Arg Gly Gly Gly Gly Thr 
            100                 105                 110         


Val Val Gly Ala Pro Arg Gly Arg Ser Ser Ser Arg Gly Arg Gly Arg 
        115                 120                 125             


Gly Arg Gly Glu Cys Gly Phe Tyr Gln Arg Ser Phe Asp Glu Val Glu 
    130                 135                 140                 


Gly Val Phe Gly Arg Gly Gly Gly Arg Glu Met His Arg Ser Gln Ser 
145                 150                 155                 160 


Trp Glu Glu Arg Gly Asp Arg Arg Phe Glu Lys Pro Gly Arg Lys Asp 
                165                 170                 175     


Val Gly Arg Pro Asn Phe Glu Glu Gly Gly Pro Thr Ser Val Gly Arg 
            180                 185                 190         


Lys His Glu Phe Ile Arg Ser Glu Ser Glu Asn Trp Arg Ile Phe Arg 
        195                 200                 205             


Glu Glu Gln Asn Gly Glu Asp Glu Asp Gly Gly Trp Arg Leu Ala Gly 
    210                 215                 220                 


Ser Arg Arg Asp Gly Glu Arg Trp Arg Pro His Ser Pro Asp Gly Pro 
225                 230                 235                 240 


Arg Ser Ala Gly Trp Arg Glu His Met Glu Arg Arg Arg Arg Phe Glu 
                245                 250                 255     


Phe Asp Phe Arg Asp Arg Asp Asp Glu Arg Gly Tyr Arg Arg Val Arg 
            260                 265                 270         


Ser Gly Ser Gly Ser Ile Asp Asp Asp Arg Asp Ser Leu Pro Glu Trp 
        275                 280                 285             


Cys Leu Glu Asp Ala Glu Glu Glu Met Gly Thr Phe Asp Ser Ser Gly 
    290                 295                 300                 


Ala Phe Leu Ser Leu Lys Lys Val Gln Lys Glu Pro Ile Pro Glu Glu 
305                 310                 315                 320 


Gln Glu Met Asp Phe Arg Pro Val Asp Glu Gly Glu Glu Cys Ser Asp 
                325                 330                 335     


Ser Glu Gly Ser His Asn Glu Glu Ala Lys Glu Pro Asp Lys Thr Asn 
            340                 345                 350         


Lys Lys Glu Gly Glu Lys Thr Asp Arg Val Gly Val Glu Ala Ser Glu 
        355                 360                 365             


Glu Thr Pro Gln Thr Ser Ser Ser Ser Ala Arg Pro Gly Thr Pro Ser 
    370                 375                 380                 


Asp His Gln Ser Gln Glu Ala Ser Gln Phe Glu Arg Lys Asp Glu Pro 
385                 390                 395                 400 


Lys Thr Glu Gln Thr Glu Lys Ala Glu Glu Glu Thr Arg Met Glu Asn 
                405                 410                 415     


Ser Leu Pro Ala Lys Val Pro Ser Arg Gly Asp Glu Met Val Ala Asp 
            420                 425                 430         


Val Gln Gln Pro Leu Ser Gln Ile Pro Ser Asp Thr Ala Ser Pro Leu 
        435                 440                 445             


Leu Ile Leu Pro Pro Pro Val Pro Asn Pro Ser Pro Thr Leu Arg Pro 
    450                 455                 460                 


Val Glu Thr Pro Val Val Gly Ala Pro Gly Met Gly Ser Val Ser Thr 
465                 470                 475                 480 


Glu Pro Asp Asp Glu Glu Gly Leu Lys His Leu Glu Gln Gln Ala Glu 
                485                 490                 495     


Lys Met Val Ala Tyr Leu Gln Asp Ser Ala Leu Asp Asp Glu Arg Leu 
            500                 505                 510         


Ala Ser Lys Leu Gln Glu His Arg Ala Lys Gly Val Ser Ile Pro Leu 
        515                 520                 525             


Met His Glu Ala Met Gln Lys Trp Tyr Tyr Lys Asp Pro Gln Gly Glu 
    530                 535                 540                 


Ile Gln Gly Pro Phe Asn Asn Gln Glu Met Ala Glu Trp Phe Gln Ala 
545                 550                 555                 560 


Gly Tyr Phe Thr Met Ser Leu Leu Val Lys Arg Ala Cys Asp Glu Ser 
                565                 570                 575     


Phe Gln Pro Leu Gly Asp Ile Met Lys Met Trp Gly Arg Val Pro Phe 
            580                 585                 590         


Ser Pro Gly Pro Ala Pro Pro Pro His Met Gly Glu Leu Asp Gln Glu 
        595                 600                 605             


Arg Leu Thr Arg Gln Gln Glu Leu Thr Ala Leu Tyr Gln Met Gln His 
    610                 615                 620                 


Leu Gln Tyr Gln Gln Phe Leu Ile Gln Gln Gln Tyr Ala Gln Val Leu 
625                 630                 635                 640 


Ala Gln Gln Gln Lys Ala Ala Leu Ser Ser Gln Gln Gln Gln Gln Leu 
                645                 650                 655     


Ala Leu Leu Leu Gln Gln Phe Gln Thr Leu Lys Met Arg Ile Ser Asp 
            660                 665                 670         


Gln Asn Ile Ile Pro Ser Val Thr Arg Ser Val Ser Val Pro Asp Thr 
        675                 680                 685             


Gly Ser Ile Trp Glu Leu Gln Pro Thr Ala Ser Gln Pro Thr Val Trp 
    690                 695                 700                 


Glu Gly Gly Ser Val Trp Asp Leu Pro Leu Asp Thr Thr Thr Pro Gly 
705                 710                 715                 720 


Pro Ala Leu Glu Gln Leu Gln Gln Leu Glu Lys Ala Lys Ala Ala Lys 
                725                 730                 735     


Leu Glu Gln Glu Arg Arg Glu Ala Glu Met Arg Ala Lys Arg Glu Glu 
            740                 745                 750         


Glu Glu Arg Lys Arg Gln Glu Glu Leu Arg Arg Gln Gln Glu Glu Ile 
        755                 760                 765             


Leu Arg Arg Gln Gln Glu Glu Glu Arg Lys Arg Arg Glu Glu Glu Glu 
    770                 775                 780                 


Leu Ala Arg Arg Lys Gln Glu Glu Ala Leu Arg Arg Gln Arg Glu Gln 
785                 790                 795                 800 


Glu Ile Ala Leu Arg Arg Gln Arg Glu Glu Glu Glu Arg Gln Gln Gln 
                805                 810                 815     


Glu Glu Ala Leu Arg Arg Leu Glu Glu Arg Arg Arg Glu Glu Glu Glu 
            820                 825                 830         


Arg Arg Lys Gln Glu Glu Leu Leu Arg Lys Gln Glu Glu Glu Ala Ala 
        835                 840                 845             


Lys Trp Ala Arg Glu Glu Glu Glu Ala Gln Arg Arg Leu Glu Glu Asn 
    850                 855                 860                 


Arg Leu Arg Met Glu Glu Glu Ala Ala Arg Leu Arg His Glu Glu Glu 
865                 870                 875                 880 


Glu Arg Lys Arg Lys Glu Leu Glu Val Gln Arg Gln Lys Glu Leu Met 
                885                 890                 895     


Arg Gln Arg Gln Gln Gln Gln Glu Ala Leu Arg Arg Leu Gln Gln Gln 
            900                 905                 910         


Gln Gln Gln Gln Gln Leu Ala Gln Met Lys Leu Pro Ser Ser Ser Thr 
        915                 920                 925             


Trp Gly Gln Gln Ser Asn Thr Thr Ala Cys Gln Ser Gln Ala Thr Leu 
    930                 935                 940                 


Ser Leu Ala Glu Ile Gln Lys Leu Glu Glu Glu Arg Glu Arg Gln Leu 
945                 950                 955                 960 


Arg Glu Glu Gln Arg Arg Gln Gln Arg Glu Leu Met Lys Ala Leu Gln 
                965                 970                 975     


Gln Gln Gln Gln Gln Gln Gln Gln Lys Leu Ser Gly Trp Gly Asn Val 
            980                 985                 990         


Ser Lys Pro Ser Gly Thr Thr Lys  Ser Leu Leu Glu Ile  Gln Gln Glu 
        995                 1000                 1005             


Glu Ala  Arg Gln Met Gln Lys  Gln Gln Gln Gln Gln  Gln Gln His 
    1010                 1015                 1020             


Gln Gln  Pro Asn Arg Ala Arg  Asn Asn Thr His Ser  Asn Leu His 
    1025                 1030                 1035             


Thr Ser  Ile Gly Asn Ser Val  Trp Gly Ser Ile Asn  Thr Gly Pro 
    1040                 1045                 1050             


Pro Asn  Gln Trp Ala Ser Asp  Leu Val Ser Ser Ile  Trp Ser Asn 
    1055                 1060                 1065             


Ala Asp  Thr Lys Asn Ser Asn  Met Gly Phe Trp Asp  Asp Ala Val 
    1070                 1075                 1080             


Lys Glu  Val Gly Pro Arg Asn  Ser Thr Asn Lys Asn  Lys Asn Asn 
    1085                 1090                 1095             


Ala Ser  Leu Ser Lys Ser Val  Gly Val Ser Asn Arg  Gln Asn Lys 
    1100                 1105                 1110             


Lys Val  Glu Glu Glu Glu Lys  Leu Leu Lys Leu Phe  Gln Gly Val 
    1115                 1120                 1125             


Asn Lys  Ala Gln Asp Gly Phe  Thr Gln Trp Cys Glu  Gln Met Leu 
    1130                 1135                 1140             


His Ala  Leu Asn Thr Ala Asn  Asn Leu Asp Val Pro  Thr Phe Val 
    1145                 1150                 1155             


Ser Phe  Leu Lys Glu Val Glu  Ser Pro Tyr Glu Val  His Asp Tyr 
    1160                 1165                 1170             


Ile Arg  Ala Tyr Leu Gly Asp  Thr Ser Glu Ala Lys  Glu Phe Ala 
    1175                 1180                 1185             


Lys Gln  Phe Leu Glu Arg Arg  Ala Lys Gln Lys Ala  Asn Gln Gln 
    1190                 1195                 1200             


Arg Gln  Gln Gln Gln Leu Pro  Gln Gln Gln Gln Gln  Gln Pro Pro 
    1205                 1210                 1215             


Gln Gln  Pro Pro Gln Gln Pro  Gln Gln Gln Asp Ser  Val Trp Gly 
    1220                 1225                 1230             


Met Asn  His Ser Thr Leu His  Ser Val Phe Gln Thr  Asn Gln Ser 
    1235                 1240                 1245             


Asn Asn  Gln Gln Ser Asn Phe  Glu Ala Val Gln Ser  Gly Lys Lys 
    1250                 1255                 1260             


Lys Lys  Lys Gln Lys Met Val  Arg Ala Asp Pro Ser  Leu Leu Gly 
    1265                 1270                 1275             


Phe Ser  Val Asn Ala Ser Ser  Glu Arg Leu Asn Met  Gly Glu Ile 
    1280                 1285                 1290             


Glu Thr  Leu Asp Asp Tyr 
    1295                 


<210>  53
<211>  2695
<212>  DNA
<213>  Homosapiens

<400>  53
catcttgtgt tgttgaggct gaggactgac tggggttctg agactccctg tcccggaccg     60

cagcgttaaa aggatctgaa caaagtctgc tcaaatctcc tgctgtgaac cagcagaatt    120

tttgaacagg tttcttcaca tataaaaatc tattgtaaaa atacggaaaa gaatggcagc    180

ggaaacgcag acactgaact ttgggcctga atggctccga gctctgtcca gtggtgggag    240

tattacatcc cctcctcttt ctccagcatt gccgaagtat aaattagcag attatcgtta    300

cggcagagaa gaaatgttag cacttttcct taaagacaac aagatacctt cagaccttct    360

ggataaagaa tttctgccta tcctccagga ggaacccctt ccaccattgg ctctggtacc    420

ctttacagaa gaagaacaga gaaacttttc catgtctgta aatagtgctg ctgtcctgcg    480

attgacagga cgaggaggag gaggaacagt ggtgggggct cctagaggtc gaagttcttc    540

aagagggcga ggcagaggca gaggtgaatg tggtttctac caaagaagtt ttgatgaagt    600

agagggtgtt tttggtcgag gaggtggcag agaaatgcat agatcgcaga gctgggagga    660

aaggggtgac agacgttttg aaaaaccagg acgaaaagat gtagggagac caaattttga    720

ggaaggtgga ccaacatcag tagggagaaa gcatgaattt atacgctcag aaagtgaaaa    780

ttggcgcatc tttagagagg aacaaaatgg agaagatgaa gatggaggtt ggcgactagc    840

tggatcaagg agggatggag agaggtggcg acctcacagt cctgatggcc ctcgttctgc    900

aggctggcgg gaacacatgg aacgacgtcg gaggtttgag tttgattttc gagatagaga    960

tgatgaacgg ggttaccgaa gggttcgctc tggcagtggg agcatagatg atgacaggga   1020

tagcttgccc gaatggtgct tagaggatgc tgaagaagaa atgggtacat ttgactcatc   1080

tggagcattc ctttctctaa aaaaagtaca gaaagagcct attccagaag agcaggagat   1140

ggacttccgg cctgtggacg aaggggagga gtgctctgac tctgagggta gccataatga   1200

agaggccaaa gaacccgata agacaaataa gaaagaagga gagaaaacag atagagtagg   1260

agttgaagct agtgaggaaa ctccccagac ctcatcatca tctgctagac caggtactcc   1320

ttcagaccat cagtctcagg aagcatcaca gtttgagagg aaagatgaac caaaaactga   1380

gcaaacggaa aaagctgaag aggagactcg gatggaaaat agtctaccag ccaaagtgcc   1440

cagcagaggg gatgaaatgg ttgctgatgt ccagcagccc ctgtcgcaga ttccttcaga   1500

tacagcctct cctcttctca tacttccacc tcctgttccc aatcctagtc ctactctccg   1560

gccagttgaa acaccagttg taggtgctcc tggtatgggc agtgtttcca cagaacctga   1620

tgatgaagaa ggtctcaaac atttggagca gcaagctgag aaaatggtgg cttatctcca   1680

agacagtgca ctagatgatg aaagattggc atcaaaactg caagagcaca gagctaaagg   1740

agtgtcgatt ccattgatgc atgaagcaat gcagaagtgg tattacaaag atcctcaggg   1800

agaaattcaa ggtcccttca ataatcagga gatggcagaa tggtttcagg cgggctattt   1860

tactatgtct ttattggtga agagagcgtg tgatgaaagc ttccaacctc ttggcgatat   1920

catgaaaatg tggggaaggg ttcccttttc tccaggtcca gctccccctc ctcatatggg   1980

agagctggac caggaacgac tgaccaggca gcaagaactc acagccttat accagatgca   2040

gcacctgcag taccagcagt ttttaataca acaacaatat gcacaggttt tggcccaaca   2100

gcagaaagca gcactgtctt cccagcagca gcagcagttg gcacttcttc ttcaacagtt   2160

tcagaccttg aagatgagaa tatctgatca gaacatcatt ccctcagtaa ctaggtctgt   2220

gtccgtgcca gatactggct ctatctggga gcttcagcca acagcttcac agcctacagt   2280

ttgggaaggt ggtagtgtat gggatcttcc tctggacacc acgacaccag gccctgccct   2340

ggaacagctt cagcagctag agaaggccaa agctgcaaag ctagagcaag agagaagaga   2400

ggcagaaatg agggcaaaac gggaagagga agagcgaaag aggcaggaag aactccgaag   2460

acaacaggag gaaattcttc ggcgacagca ggaagaagaa aggaaaaggc gagaggaaga   2520

agaacttgcc cgaaggaaac aggaagaggc tctgcgtcgc cagcgggagc aagaaattgc   2580

attaaggcga cagcgagaag aggaagaaag acagcagcaa gaagaagctc ttagaagact   2640

ggaagagagg agaagagaag aggaagaaag gcggaagcag gaagaattgt tacgc        2695


<210>  54
<211>  840
<212>  PRT
<213>  Homosapiens

<400>  54

Met Ala Ala Glu Thr Gln Thr Leu Asn Phe Gly Pro Glu Trp Leu Arg 
1               5                   10                  15      


Ala Leu Ser Ser Gly Gly Ser Ile Thr Ser Pro Pro Leu Ser Pro Ala 
            20                  25                  30          


Leu Pro Lys Tyr Lys Leu Ala Asp Tyr Arg Tyr Gly Arg Glu Glu Met 
        35                  40                  45              


Leu Ala Leu Phe Leu Lys Asp Asn Lys Ile Pro Ser Asp Leu Leu Asp 
    50                  55                  60                  


Lys Glu Phe Leu Pro Ile Leu Gln Glu Glu Pro Leu Pro Pro Leu Ala 
65                  70                  75                  80  


Leu Val Pro Phe Thr Glu Glu Glu Gln Arg Asn Phe Ser Met Ser Val 
                85                  90                  95      


Asn Ser Ala Ala Val Leu Arg Leu Thr Gly Arg Gly Gly Gly Gly Thr 
            100                 105                 110         


Val Val Gly Ala Pro Arg Gly Arg Ser Ser Ser Arg Gly Arg Gly Arg 
        115                 120                 125             


Gly Arg Gly Glu Cys Gly Phe Tyr Gln Arg Ser Phe Asp Glu Val Glu 
    130                 135                 140                 


Gly Val Phe Gly Arg Gly Gly Gly Arg Glu Met His Arg Ser Gln Ser 
145                 150                 155                 160 


Trp Glu Glu Arg Gly Asp Arg Arg Phe Glu Lys Pro Gly Arg Lys Asp 
                165                 170                 175     


Val Gly Arg Pro Asn Phe Glu Glu Gly Gly Pro Thr Ser Val Gly Arg 
            180                 185                 190         


Lys His Glu Phe Ile Arg Ser Glu Ser Glu Asn Trp Arg Ile Phe Arg 
        195                 200                 205             


Glu Glu Gln Asn Gly Glu Asp Glu Asp Gly Gly Trp Arg Leu Ala Gly 
    210                 215                 220                 


Ser Arg Arg Asp Gly Glu Arg Trp Arg Pro His Ser Pro Asp Gly Pro 
225                 230                 235                 240 


Arg Ser Ala Gly Trp Arg Glu His Met Glu Arg Arg Arg Arg Phe Glu 
                245                 250                 255     


Phe Asp Phe Arg Asp Arg Asp Asp Glu Arg Gly Tyr Arg Arg Val Arg 
            260                 265                 270         


Ser Gly Ser Gly Ser Ile Asp Asp Asp Arg Asp Ser Leu Pro Glu Trp 
        275                 280                 285             


Cys Leu Glu Asp Ala Glu Glu Glu Met Gly Thr Phe Asp Ser Ser Gly 
    290                 295                 300                 


Ala Phe Leu Ser Leu Lys Lys Val Gln Lys Glu Pro Ile Pro Glu Glu 
305                 310                 315                 320 


Gln Glu Met Asp Phe Arg Pro Val Asp Glu Gly Glu Glu Cys Ser Asp 
                325                 330                 335     


Ser Glu Gly Ser His Asn Glu Glu Ala Lys Glu Pro Asp Lys Thr Asn 
            340                 345                 350         


Lys Lys Glu Gly Glu Lys Thr Asp Arg Val Gly Val Glu Ala Ser Glu 
        355                 360                 365             


Glu Thr Pro Gln Thr Ser Ser Ser Ser Ala Arg Pro Gly Thr Pro Ser 
    370                 375                 380                 


Asp His Gln Ser Gln Glu Ala Ser Gln Phe Glu Arg Lys Asp Glu Pro 
385                 390                 395                 400 


Lys Thr Glu Gln Thr Glu Lys Ala Glu Glu Glu Thr Arg Met Glu Asn 
                405                 410                 415     


Ser Leu Pro Ala Lys Val Pro Ser Arg Gly Asp Glu Met Val Ala Asp 
            420                 425                 430         


Val Gln Gln Pro Leu Ser Gln Ile Pro Ser Asp Thr Ala Ser Pro Leu 
        435                 440                 445             


Leu Ile Leu Pro Pro Pro Val Pro Asn Pro Ser Pro Thr Leu Arg Pro 
    450                 455                 460                 


Val Glu Thr Pro Val Val Gly Ala Pro Gly Met Gly Ser Val Ser Thr 
465                 470                 475                 480 


Glu Pro Asp Asp Glu Glu Gly Leu Lys His Leu Glu Gln Gln Ala Glu 
                485                 490                 495     


Lys Met Val Ala Tyr Leu Gln Asp Ser Ala Leu Asp Asp Glu Arg Leu 
            500                 505                 510         


Ala Ser Lys Leu Gln Glu His Arg Ala Lys Gly Val Ser Ile Pro Leu 
        515                 520                 525             


Met His Glu Ala Met Gln Lys Trp Tyr Tyr Lys Asp Pro Gln Gly Glu 
    530                 535                 540                 


Ile Gln Gly Pro Phe Asn Asn Gln Glu Met Ala Glu Trp Phe Gln Ala 
545                 550                 555                 560 


Gly Tyr Phe Thr Met Ser Leu Leu Val Lys Arg Ala Cys Asp Glu Ser 
                565                 570                 575     


Phe Gln Pro Leu Gly Asp Ile Met Lys Met Trp Gly Arg Val Pro Phe 
            580                 585                 590         


Ser Pro Gly Pro Ala Pro Pro Pro His Met Gly Glu Leu Asp Gln Glu 
        595                 600                 605             


Arg Leu Thr Arg Gln Gln Glu Leu Thr Ala Leu Tyr Gln Met Gln His 
    610                 615                 620                 


Leu Gln Tyr Gln Gln Phe Leu Ile Gln Gln Gln Tyr Ala Gln Val Leu 
625                 630                 635                 640 


Ala Gln Gln Gln Lys Ala Ala Leu Ser Ser Gln Gln Gln Gln Gln Leu 
                645                 650                 655     


Ala Leu Leu Leu Gln Gln Phe Gln Thr Leu Lys Met Arg Ile Ser Asp 
            660                 665                 670         


Gln Asn Ile Ile Pro Ser Val Thr Arg Ser Val Ser Val Pro Asp Thr 
        675                 680                 685             


Gly Ser Ile Trp Glu Leu Gln Pro Thr Ala Ser Gln Pro Thr Val Trp 
    690                 695                 700                 


Glu Gly Gly Ser Val Trp Asp Leu Pro Leu Asp Thr Thr Thr Pro Gly 
705                 710                 715                 720 


Pro Ala Leu Glu Gln Leu Gln Gln Leu Glu Lys Ala Lys Ala Ala Lys 
                725                 730                 735     


Leu Glu Gln Glu Arg Arg Glu Ala Glu Met Arg Ala Lys Arg Glu Glu 
            740                 745                 750         


Glu Glu Arg Lys Arg Gln Glu Glu Leu Arg Arg Gln Gln Glu Glu Ile 
        755                 760                 765             


Leu Arg Arg Gln Gln Glu Glu Glu Arg Lys Arg Arg Glu Glu Glu Glu 
    770                 775                 780                 


Leu Ala Arg Arg Lys Gln Glu Glu Ala Leu Arg Arg Gln Arg Glu Gln 
785                 790                 795                 800 


Glu Ile Ala Leu Arg Arg Gln Arg Glu Glu Glu Glu Arg Gln Gln Gln 
                805                 810                 815     


Glu Glu Ala Leu Arg Arg Leu Glu Glu Arg Arg Arg Glu Glu Glu Glu 
            820                 825                 830         


Arg Arg Lys Gln Glu Glu Leu Leu 
        835                 840 


<210>  55
<211>  5838
<212>  DNA
<213>  Homosapiens

<400>  55
catcttgtgt tgttgaggct gaggactgac tggggttctg agactccctg tcccggaccg     60

cagcgttaaa aggatctgaa caaagtctgc tcaaatctcc tgctgtgaac cagcagaatt    120

tttgaacagg tttcttcaca tataaaaatc tattgtaaaa atacggaaaa gaatggcagc    180

ggaaacgcag acactgaact ttgggcctga atggctccga gctctgtcca gtggtgggag    240

tattacatcc cctcctcttt ctccagcatt gccgaagtat aaattagcag attatcgtta    300

cggcagagaa gaaatgttag cacttttcct taaagacaac aagatacctt cagaccttct    360

ggataaagaa tttctgccta tcctccagga ggaacccctt ccaccattgg ctctggtacc    420

ctttacagaa gaagaacaga gaaacttttc catgtctgta aatagtgctg ctgtcctgcg    480

attgacagga cgaggaggag gaggaacagt ggtgggggct cctagaggtc gaagttcttc    540

aagagggcga ggcagaggca gaggtgaatg tggtttctac caaagaagtt ttgatgaagt    600

agagggtgtt tttggtcgag gaggtggcag agaaatgcat agatcgcaga gctgggagga    660

aaggggtgac agacgttttg aaaaaccagg acgaaaagat gtagggagac caaattttga    720

ggaaggtgga ccaacatcag tagggagaaa gcatgaattt atacgctcag aaagtgaaaa    780

ttggcgcatc tttagagagg aacaaaatgg agaagatgaa gatggaggtt ggcgactagc    840

tggatcaagg agggatggag agaggtggcg acctcacagt cctgatggcc ctcgttctgc    900

aggctggcgg gaacacatgg aacgacgtcg gaggtttgag tttgattttc gagatagaga    960

tgatgaacgg ggttaccgaa gggttcgctc tggcagtggg agcatagatg atgacaggga   1020

tagcttgccc gaatggtgct tagaggatgc tgaagaagaa atgggtacat ttgactcatc   1080

tggagcattc ctttctctaa aaaaagtaca gaaagagcct attccagaag agcaggagat   1140

ggacttccgg cctgtggacg aaggggagga gtgctctgac tctgagggta gccataatga   1200

agaggccaaa gaacccgata agacaaataa gaaagaagga gagaaaacag atagagtagg   1260

agttgaagct agtgaggaaa ctccccagac ctcatcatca tctgctagac caggtactcc   1320

ttcagaccat cagtctcagg aagcatcaca gtttgagagg aaagatgaac caaaaactga   1380

gcaaacggaa aaagctgaag aggagactcg gatggaaaat agtctaccag ccaaagtgcc   1440

cagcagaggg gatgaaatgg ttgctgatgt ccagcagccc ctgtcgcaga ttccttcaga   1500

tacagcctct cctcttctca tacttccacc tcctgttccc aatcctagtc ctactctccg   1560

gccagttgaa acaccagttg taggtgctcc tggtatgggc agtgtttcca cagaacctga   1620

tgatgaagaa ggtctcaaac atttggagca gcaagctgag aaaatggtgg cttatctcca   1680

agacagtgca ctagatgatg aaagattggc atcaaaactg caagagcaca gagctaaagg   1740

agtgtcgatt ccattgatgc atgaagcaat gcagaagtgg tattacaaag atcctcaggg   1800

agaaattcaa ggtcccttca ataatcagga gatggcagaa tggtttcagg cgggctattt   1860

tactatgtct ttattggtga agagagcgtg tgatgaaagc ttccaacctc ttggcgatat   1920

catgaaaatg tggggaaggg ttcccttttc tccaggtcca gctccccctc ctcatatggg   1980

agagctggac caggaacgac tgaccaggca gcaagaactc acagccttat accagatgca   2040

gcacctgcag taccagcagt ttttaataca acaacaatat gcacaggttt tggcccaaca   2100

gcagaaagca gcactgtctt cccagcagca gcagcagttg gcacttcttc ttcaacagtt   2160

tcagaccttg aagatgagaa tatctgatca gaacatcatt ccctcagtaa ctaggtctgt   2220

gtccgtgcca gatactggct ctatctggga gcttcagcca acagcttcac agcctacagt   2280

ttgggaaggt ggtagtgtat gggatcttcc tctggacacc acgacaccag gccctgccct   2340

ggaacagctt cagcagctag agaaggccaa agctgcaaag ctagagcaag agagaagaga   2400

ggcagaaatg agggcaaaac gggaagagga agagcgaaag aggcaggaag aactccgaag   2460

acaacaggag gaaattcttc ggcgacagca ggaagaagaa aggaaaaggc gagaggaaga   2520

agaacttgcc cgaaggaaac aggaagaggc tctgcgtcgc cagcgggagc aagaaattgc   2580

attaaggcga cagcgagaag aggaagaaag acagcagcaa gaagaagctc ttagaagact   2640

ggaagagagg agaagagaag aggaagaaag gcggaagcag gaagaattgt tacgcaaaca   2700

ggaagaggag gctgcaaaat gggcccggga agaagaagaa gcccagcgtc gattagagga   2760

gaaccggctg cggatggaag aggaggcagc cagactccgg catgaggaag aagaacggaa   2820

gagaaaggag ctggaggtcc agcggcagaa ggagttaatg cgccagaggc agcagcagca   2880

agaggctctc cggaggttgc agcagcagca gcagcaacaa cagctggcgc agatgaagct   2940

tccttcttct tcaacgtggg gccagcagtc caatacaaca gcatgtcagt cccaggccac   3000

gctgtcgttg gctgaaatcc aaaaactaga ggaagaacga gaacggcagc ttcgagaaga   3060

gcaaaggcgc cagcagaggg agttgatgaa agctcttcag cagcagcagc aacagcaaca   3120

gcagaaactc tcaggttggg ggaatgtcag caaaccttca ggtaccacga aatctcttct   3180

ggagatccag caggaagagg ccaggcaaat gcaaaagcag cagcagcagc agcagcaaca   3240

ccagcaacca aacagagctc gtaacaatac gcattccaac ctgcacacca gcattgggaa   3300

ttctgtttgg ggctctataa atactggtcc tcctaaccag tgggcatctg acctagtcag   3360

tagtatttgg agtaatgctg acactaaaaa ctccaacatg ggattctggg atgatgcagt   3420

gaaagaggtg ggacctagga attcaacaaa taaaaataaa aacaacgcca gtctcagtaa   3480

atctgtaggt gtgtctaacc ggcagaataa gaaagtagaa gaagaagaaa agttgctgaa   3540

gctctttcag ggagtaaata aagcccaaga tggatttacg cagtggtgtg aacagatgct   3600

tcatgccctt aatacggcaa ataacttgga tgttcccaca tttgtttctt tcctgaaaga   3660

agtagaatct ccttatgagg tccatgatta tatcagggcc tatttaggag atacttctga   3720

ggccaaggag tttgccaagc agttccttga gcgccgtgcc aaacagaaag ccaaccagca   3780

gcgtcagcag cagcagctgc cacagcagca gcagcagcag ccgccacagc agccgccaca   3840

gcagccacaa cagcaggact ctgtgtgggg gatgaaccac agtacactcc attcagtatt   3900

tcagaccaat caaagcaaca accaacaatc caattttgag gctgtgcaga gtggcaagaa   3960

gaagaaaaag cagaagatgg tccgagcaga tcccagttta ttaggatttt cagtcaatgc   4020

atcatcggag cgactcaaca tgggtgaaat cgagacgttg gatgactact gagcacctgc   4080

cagtggactg gccatccctc tcctgtctgc cgactatgga gtctccacct ttggacacaa   4140

cacttactca ccatttactc tttatcactc tgcaacaaat cacagaaccg atcatctcag   4200

gctttttctt ctggcccttt gtgtccaaga ttctttaatc catttttgtt ggtgaacatc   4260

tcagactata gataagtgga ctggaccctg tgtcttgggg gtggcagttg ggattactcc   4320

ccaacaaggc tgattttagg cagcatgtgt tcactgtgct gtgatttcat ctactgtctc   4380

ccagaaagtg tgttgggatc ggccattagc agcttgcttt ctcttgtcac tttttttctt   4440

ctattttgtt ttttcttctt ctttttcccc ccatcagggc aaatggtcta actggtgcaa   4500

tcatgaagag agttaatggt taacagacat tggccaataa caaaacaccc catggactgt   4560

gactcgagta tccaacaggc agtcagagct ctcccggtct gaaagttgca ttgccactgc   4620

taactttggg attgcatcag agaggccctg agtggggttg agatgaggtt ggtttggttt   4680

gatgttacac actcctcacc tgttctttct gagtgtcctt tctctgaaag gatttatgtt   4740

tttcttcgtt agatagtgac ttctgagcaa gctgatctcc cctggcatgc tccaacctga   4800

ttggacaaag gaagctctat ggcctgggag agagactatt cttaattttt ctttcttaca   4860

aaaactgatt tttcccataa atatttttac ttcagaggac taggaccatt ttgttttggg   4920

cccttctgct gaaaatttgt ctcgtttaag aggcagctag aatctttacc atatgtatga   4980

atttgtataa tttcattttt ggatagggat aaacttttgc ttctgataaa agcctggaat   5040

ttcatctggt cctcagagca ttgcgtgtgt gtcttgctgt agcccggaaa aggttttgtg   5100

taaagattct gggatggcaa gttgtttgcc ttttctgaaa agagaacata cagaacctgt   5160

ccatctttaa gaccttcatc catggaatct actatacagg aggatgcagt gggctggagg   5220

ggatgggcga aaatgggagc aggaagcctg gcctggcttc tggtcatggc ctcctaaaac   5280

cttaaacttc aagtagaaat gtactcaagc cctatttata aacaaatact tttcctgcct   5340

ccaccaaacc cctacagaac atcacctgga attgccactc acactgggtt ggagtcattg   5400

ggcagctgtg cctgtgcgag aggtgctgtg gtctgggcag cccctggaaa agcacctttg   5460

ctgcctgtca ttgttgcctg aagaaggctg gagttgctct gagagcagtt tgggtttgga   5520

gtattatatt tggcttctat ttttattatt ttggatcacc attctcccta tcccttcttg   5580

cctccctccc ttctaaacat gtgtaataac tatacagaga ctgctacaaa attgtatata   5640

gtttttggat caaatagcat gaggggagag gaaaccatta aaagttgggg ctcctactct   5700

cctttgcttt gtaaattcaa aagttggggg tgggtaagag ggatagttaa aatgtttaca   5760

aaactttagg ctccctcgga acttttgcca gtgtggagga aaataaaaaa gaacttaaat   5820

aaaatctgat tgtattct                                                 5838


<210>  56
<211>  1299
<212>  PRT
<213>  Homosapiens

<400>  56

Met Ala Ala Glu Thr Gln Thr Leu Asn Phe Gly Pro Glu Trp Leu Arg 
1               5                   10                  15      


Ala Leu Ser Ser Gly Gly Ser Ile Thr Ser Pro Pro Leu Ser Pro Ala 
            20                  25                  30          


Leu Pro Lys Tyr Lys Leu Ala Asp Tyr Arg Tyr Gly Arg Glu Glu Met 
        35                  40                  45              


Leu Ala Leu Phe Leu Lys Asp Asn Lys Ile Pro Ser Asp Leu Leu Asp 
    50                  55                  60                  


Lys Glu Phe Leu Pro Ile Leu Gln Glu Glu Pro Leu Pro Pro Leu Ala 
65                  70                  75                  80  


Leu Val Pro Phe Thr Glu Glu Glu Gln Arg Asn Phe Ser Met Ser Val 
                85                  90                  95      


Asn Ser Ala Ala Val Leu Arg Leu Thr Gly Arg Gly Gly Gly Gly Thr 
            100                 105                 110         


Val Val Gly Ala Pro Arg Gly Arg Ser Ser Ser Arg Gly Arg Gly Arg 
        115                 120                 125             


Gly Arg Gly Glu Cys Gly Phe Tyr Gln Arg Ser Phe Asp Glu Val Glu 
    130                 135                 140                 


Gly Val Phe Gly Arg Gly Gly Gly Arg Glu Met His Arg Ser Gln Ser 
145                 150                 155                 160 


Trp Glu Glu Arg Gly Asp Arg Arg Phe Glu Lys Pro Gly Arg Lys Asp 
                165                 170                 175     


Val Gly Arg Pro Asn Phe Glu Glu Gly Gly Pro Thr Ser Val Gly Arg 
            180                 185                 190         


Lys His Glu Phe Ile Arg Ser Glu Ser Glu Asn Trp Arg Ile Phe Arg 
        195                 200                 205             


Glu Glu Gln Asn Gly Glu Asp Glu Asp Gly Gly Trp Arg Leu Ala Gly 
    210                 215                 220                 


Ser Arg Arg Asp Gly Glu Arg Trp Arg Pro His Ser Pro Asp Gly Pro 
225                 230                 235                 240 


Arg Ser Ala Gly Trp Arg Glu His Met Glu Arg Arg Arg Arg Phe Glu 
                245                 250                 255     


Phe Asp Phe Arg Asp Arg Asp Asp Glu Arg Gly Tyr Arg Arg Val Arg 
            260                 265                 270         


Ser Gly Ser Gly Ser Ile Asp Asp Asp Arg Asp Ser Leu Pro Glu Trp 
        275                 280                 285             


Cys Leu Glu Asp Ala Glu Glu Glu Met Gly Thr Phe Asp Ser Ser Gly 
    290                 295                 300                 


Ala Phe Leu Ser Leu Lys Lys Val Gln Lys Glu Pro Ile Pro Glu Glu 
305                 310                 315                 320 


Gln Glu Met Asp Phe Arg Pro Val Asp Glu Gly Glu Glu Cys Ser Asp 
                325                 330                 335     


Ser Glu Gly Ser His Asn Glu Glu Ala Lys Glu Pro Asp Lys Thr Asn 
            340                 345                 350         


Lys Lys Glu Gly Glu Lys Thr Asp Arg Val Gly Val Glu Ala Ser Glu 
        355                 360                 365             


Glu Thr Pro Gln Thr Ser Ser Ser Ser Ala Arg Pro Gly Thr Pro Ser 
    370                 375                 380                 


Asp His Gln Ser Gln Glu Ala Ser Gln Phe Glu Arg Lys Asp Glu Pro 
385                 390                 395                 400 


Lys Thr Glu Gln Thr Glu Lys Ala Glu Glu Glu Thr Arg Met Glu Asn 
                405                 410                 415     


Ser Leu Pro Ala Lys Val Pro Ser Arg Gly Asp Glu Met Val Ala Asp 
            420                 425                 430         


Val Gln Gln Pro Leu Ser Gln Ile Pro Ser Asp Thr Ala Ser Pro Leu 
        435                 440                 445             


Leu Ile Leu Pro Pro Pro Val Pro Asn Pro Ser Pro Thr Leu Arg Pro 
    450                 455                 460                 


Val Glu Thr Pro Val Val Gly Ala Pro Gly Met Gly Ser Val Ser Thr 
465                 470                 475                 480 


Glu Pro Asp Asp Glu Glu Gly Leu Lys His Leu Glu Gln Gln Ala Glu 
                485                 490                 495     


Lys Met Val Ala Tyr Leu Gln Asp Ser Ala Leu Asp Asp Glu Arg Leu 
            500                 505                 510         


Ala Ser Lys Leu Gln Glu His Arg Ala Lys Gly Val Ser Ile Pro Leu 
        515                 520                 525             


Met His Glu Ala Met Gln Lys Trp Tyr Tyr Lys Asp Pro Gln Gly Glu 
    530                 535                 540                 


Ile Gln Gly Pro Phe Asn Asn Gln Glu Met Ala Glu Trp Phe Gln Ala 
545                 550                 555                 560 


Gly Tyr Phe Thr Met Ser Leu Leu Val Lys Arg Ala Cys Asp Glu Ser 
                565                 570                 575     


Phe Gln Pro Leu Gly Asp Ile Met Lys Met Trp Gly Arg Val Pro Phe 
            580                 585                 590         


Ser Pro Gly Pro Ala Pro Pro Pro His Met Gly Glu Leu Asp Gln Glu 
        595                 600                 605             


Arg Leu Thr Arg Gln Gln Glu Leu Thr Ala Leu Tyr Gln Met Gln His 
    610                 615                 620                 


Leu Gln Tyr Gln Gln Phe Leu Ile Gln Gln Gln Tyr Ala Gln Val Leu 
625                 630                 635                 640 


Ala Gln Gln Gln Lys Ala Ala Leu Ser Ser Gln Gln Gln Gln Gln Leu 
                645                 650                 655     


Ala Leu Leu Leu Gln Gln Phe Gln Thr Leu Lys Met Arg Ile Ser Asp 
            660                 665                 670         


Gln Asn Ile Ile Pro Ser Val Thr Arg Ser Val Ser Val Pro Asp Thr 
        675                 680                 685             


Gly Ser Ile Trp Glu Leu Gln Pro Thr Ala Ser Gln Pro Thr Val Trp 
    690                 695                 700                 


Glu Gly Gly Ser Val Trp Asp Leu Pro Leu Asp Thr Thr Thr Pro Gly 
705                 710                 715                 720 


Pro Ala Leu Glu Gln Leu Gln Gln Leu Glu Lys Ala Lys Ala Ala Lys 
                725                 730                 735     


Leu Glu Gln Glu Arg Arg Glu Ala Glu Met Arg Ala Lys Arg Glu Glu 
            740                 745                 750         


Glu Glu Arg Lys Arg Gln Glu Glu Leu Arg Arg Gln Gln Glu Glu Ile 
        755                 760                 765             


Leu Arg Arg Gln Gln Glu Glu Glu Arg Lys Arg Arg Glu Glu Glu Glu 
    770                 775                 780                 


Leu Ala Arg Arg Lys Gln Glu Glu Ala Leu Arg Arg Gln Arg Glu Gln 
785                 790                 795                 800 


Glu Ile Ala Leu Arg Arg Gln Arg Glu Glu Glu Glu Arg Gln Gln Gln 
                805                 810                 815     


Glu Glu Ala Leu Arg Arg Leu Glu Glu Arg Arg Arg Glu Glu Glu Glu 
            820                 825                 830         


Arg Arg Lys Gln Glu Glu Leu Leu Arg Lys Gln Glu Glu Glu Ala Ala 
        835                 840                 845             


Lys Trp Ala Arg Glu Glu Glu Glu Ala Gln Arg Arg Leu Glu Glu Asn 
    850                 855                 860                 


Arg Leu Arg Met Glu Glu Glu Ala Ala Arg Leu Arg His Glu Glu Glu 
865                 870                 875                 880 


Glu Arg Lys Arg Lys Glu Leu Glu Val Gln Arg Gln Lys Glu Leu Met 
                885                 890                 895     


Arg Gln Arg Gln Gln Gln Gln Glu Ala Leu Arg Arg Leu Gln Gln Gln 
            900                 905                 910         


Gln Gln Gln Gln Gln Leu Ala Gln Met Lys Leu Pro Ser Ser Ser Thr 
        915                 920                 925             


Trp Gly Gln Gln Ser Asn Thr Thr Ala Cys Gln Ser Gln Ala Thr Leu 
    930                 935                 940                 


Ser Leu Ala Glu Ile Gln Lys Leu Glu Glu Glu Arg Glu Arg Gln Leu 
945                 950                 955                 960 


Arg Glu Glu Gln Arg Arg Gln Gln Arg Glu Leu Met Lys Ala Leu Gln 
                965                 970                 975     


Gln Gln Gln Gln Gln Gln Gln Gln Lys Leu Ser Gly Trp Gly Asn Val 
            980                 985                 990         


Ser Lys Pro Ser Gly Thr Thr Lys  Ser Leu Leu Glu Ile  Gln Gln Glu 
        995                 1000                 1005             


Glu Ala  Arg Gln Met Gln Lys  Gln Gln Gln Gln Gln  Gln Gln His 
    1010                 1015                 1020             


Gln Gln  Pro Asn Arg Ala Arg  Asn Asn Thr His Ser  Asn Leu His 
    1025                 1030                 1035             


Thr Ser  Ile Gly Asn Ser Val  Trp Gly Ser Ile Asn  Thr Gly Pro 
    1040                 1045                 1050             


Pro Asn  Gln Trp Ala Ser Asp  Leu Val Ser Ser Ile  Trp Ser Asn 
    1055                 1060                 1065             


Ala Asp  Thr Lys Asn Ser Asn  Met Gly Phe Trp Asp  Asp Ala Val 
    1070                 1075                 1080             


Lys Glu  Val Gly Pro Arg Asn  Ser Thr Asn Lys Asn  Lys Asn Asn 
    1085                 1090                 1095             


Ala Ser  Leu Ser Lys Ser Val  Gly Val Ser Asn Arg  Gln Asn Lys 
    1100                 1105                 1110             


Lys Val  Glu Glu Glu Glu Lys  Leu Leu Lys Leu Phe  Gln Gly Val 
    1115                 1120                 1125             


Asn Lys  Ala Gln Asp Gly Phe  Thr Gln Trp Cys Glu  Gln Met Leu 
    1130                 1135                 1140             


His Ala  Leu Asn Thr Ala Asn  Asn Leu Asp Val Pro  Thr Phe Val 
    1145                 1150                 1155             


Ser Phe  Leu Lys Glu Val Glu  Ser Pro Tyr Glu Val  His Asp Tyr 
    1160                 1165                 1170             


Ile Arg  Ala Tyr Leu Gly Asp  Thr Ser Glu Ala Lys  Glu Phe Ala 
    1175                 1180                 1185             


Lys Gln  Phe Leu Glu Arg Arg  Ala Lys Gln Lys Ala  Asn Gln Gln 
    1190                 1195                 1200             


Arg Gln  Gln Gln Gln Leu Pro  Gln Gln Gln Gln Gln  Gln Pro Pro 
    1205                 1210                 1215             


Gln Gln  Pro Pro Gln Gln Pro  Gln Gln Gln Asp Ser  Val Trp Gly 
    1220                 1225                 1230             


Met Asn  His Ser Thr Leu His  Ser Val Phe Gln Thr  Asn Gln Ser 
    1235                 1240                 1245             


Asn Asn  Gln Gln Ser Asn Phe  Glu Ala Val Gln Ser  Gly Lys Lys 
    1250                 1255                 1260             


Lys Lys  Lys Gln Lys Met Val  Arg Ala Asp Pro Ser  Leu Leu Gly 
    1265                 1270                 1275             


Phe Ser  Val Asn Ala Ser Ser  Glu Arg Leu Asn Met  Gly Glu Ile 
    1280                 1285                 1290             


Glu Thr  Leu Asp Asp Tyr 
    1295                 


<210>  57
<211>  5973
<212>  DNA
<213>  Homosapiens

<400>  57
atcttgtgtt gttgaggctg aggactgact ggggttctga gactccctgt cccggaccgc     60

agattatagt gggaccagtc tcattaggtt gaatctacag cctatgttgg tgttaaccca    120

ggtctcttag agcgttaaaa ggatctgaac aaagtctgct caaatctcct gctgtgaacc    180

agcagaattt ttgaacaggt ttcttcacat ataaaaatct attgtaaaaa tacggaaaag    240

aatggcagcg gaaacgcaga cactgaactt tgggcctgaa tggctccgag ctctgtccag    300

tggtgggagt attacatccc ctcctctttc tccagcattg ccgaagtata aattagcaga    360

ttatcgttac ggcagagaag aaatgttagc acttttcctt aaagacaaca agataccttc    420

agaccttctg gataaagaat ttctgcctat cctccaggag gaaccccttc caccattggc    480

tctggtaccc tttacagaag aagaacagag aaacttttcc atgtctgtaa atagtgctgc    540

tgtcctgcga ttgacaggac gaggaggagg aggaacagtg gtgggggctc ctagaggtcg    600

aagttcttca agagggcgag gcagaggcag aggtgaatgt ggtttctacc aaagaagttt    660

tgatgaagta gagggtgttt ttggtcgagg aggtggcaga gaaatgcata gatcgcagag    720

ctgggaggaa aggggtgaca gacgttttga aaaaccagga cgaaaagatg taggaaagaa    780

gaatggatat tattgcatgt actcaccagt tcttttgctg ggtcagcctt tatgccaagg    840

gagaccaaat tttgaggaag gtggaccaac atcagtaggg agaaagcatg aatttatacg    900

ctcagaaagt gaaaattggc gcatctttag agaggaacaa aatggagaag atgaagatgg    960

aggttggcga ctagctggat caaggaggga tggagagagg tggcgacctc acagtcctga   1020

tggccctcgt tctgcaggct ggcgggaaca catggaacga cgtcggaggt ttgagtttga   1080

ttttcgagat agagatgatg aacggggtta ccgaagggtt cgctctggca gtgggagcat   1140

agatgatgac agggatagct tgcccgaatg gtgcttagag gatgctgaag aagaaatggg   1200

tacatttgac tcatctggag cattcctttc tctaaaaaaa gtacagaaag agcctattcc   1260

agaagagcag gagatggact tccggcctgt ggacgaaggg gaggagtgct ctgactctga   1320

gggtagccat aatgaagagg ccaaagaacc cgataagaca aataagaaag aaggagagaa   1380

aacagataga gtaggagttg aagctagtga ggaaactccc cagacctcat catcatctgc   1440

tagaccaggt actccttcag accatcagtc tcaggaagca tcacagtttg agaggaaaga   1500

tgaaccaaaa actgagcaaa cggaaaaagc tgaagaggag actcggatgg aaaatagtct   1560

accagccaaa gtgcccagca gaggggatga aatggttgct gatgtccagc agcccctgtc   1620

gcagattcct tcagatacag cctctcctct tctcatactt ccacctcctg ttcccaatcc   1680

tagtcctact ctccggccag ttgaaacacc agttgtaggt gctcctggta tgggcagtgt   1740

ttccacagaa cctgatgatg aagaaggtct caaacatttg gagcagcaag ctgagaaaat   1800

ggtggcttat ctccaagaca gtgcactaga tgatgaaaga ttggcatcaa aactgcaaga   1860

gcacagagct aaaggagtgt cgattccatt gatgcatgaa gcaatgcaga agtggtatta   1920

caaagatcct cagggagaaa ttcaaggtcc cttcaataat caggagatgg cagaatggtt   1980

tcaggcgggc tattttacta tgtctttatt ggtgaagaga gcgtgtgatg aaagcttcca   2040

acctcttggc gatatcatga aaatgtgggg aagggttccc ttttctccag gtccagctcc   2100

ccctcctcat atgggagagc tggaccagga acgactgacc aggcagcaag aactcacagc   2160

cttataccag atgcagcacc tgcagtacca gcagttttta atacaacaac aatatgcaca   2220

ggttttggcc caacagcaga aagcagcact gtcttcccag cagcagcagc agttggcact   2280

tcttcttcaa cagtttcaga ccttgaagat gagaatatct gatcagaaca tcattccctc   2340

agtaactagg tctgtgtccg tgccagatac tggctctatc tgggagcttc agccaacagc   2400

ttcacagcct acagtttggg aaggtggtag tgtatgggat cttcctctgg acaccacgac   2460

accaggccct gccctggaac agcttcagca gctagagaag gccaaagctg caaagctaga   2520

gcaagagaga agagaggcag aaatgagggc aaaacgggaa gaggaagagc gaaagaggca   2580

ggaagaactc cgaagacaac aggaggaaat tcttcggcga cagcaggaag aagaaaggaa   2640

aaggcgagag gaagaagaac ttgcccgaag gaaacaggaa gaggctctgc gtcgccagcg   2700

ggagcaagaa attgcattaa ggcgacagcg agaagaggaa gaaagacagc agcaagaaga   2760

agctcttaga agactggaag agaggagaag agaagaggaa gaaaggcgga agcaggaaga   2820

attgttacgc aaacaggaag aggaggctgc aaaatgggcc cgggaagaag aagaagccca   2880

gcgtcgatta gaggagaacc ggctgcggat ggaagaggag gcagccagac tccggcatga   2940

ggaagaagaa cggaagagaa aggagctgga ggtccagcgg cagaaggagt taatgcgcca   3000

gaggcagcag cagcaagagg ctctccggag gttgcagcag cagcagcagc aacaacagct   3060

ggcgcagatg aagcttcctt cttcttcaac gtggggccag cagtccaata caacagcatg   3120

tcagtcccag gccacgctgt cgttggctga aatccaaaaa ctagaggaag aacgagaacg   3180

gcagcttcga gaagagcaaa ggcgccagca gagggagttg atgaaagctc ttcagcagca   3240

gcagcaacag caacagcaga aactctcagg ttgggggaat gtcagcaaac cttcaggtac   3300

cacgaaatct cttctggaga tccagcagga agaggccagg caaatgcaaa agcagcagca   3360

gcagcagcag caacaccagc aaccaaacag agctcgtaac aatacgcatt ccaacctgca   3420

caccagcatt gggaattctg tttggggctc tataaatact ggtcctccta accagtgggc   3480

atctgaccta gtcagtagta tttggagtaa tgctgacact aaaaactcca acatgggatt   3540

ctgggatgat gcagtgaaag aggtgggacc taggaattca acaaataaaa ataaaaacaa   3600

cgccagtctc agtaaatctg taggtgtgtc taaccggcag aataagaaag tagaagaaga   3660

agaaaagttg ctgaagctct ttcagggagt aaataaagcc caagatggat ttacgcagtg   3720

gtgtgaacag atgcttcatg cccttaatac ggcaaataac ttggatgttc ccacatttgt   3780

ttctttcctg aaagaagtag aatctcctta tgaggtccat gattatatca gggcctattt   3840

aggagatact tctgaggcca aggagtttgc caagcagttc cttgagcgcc gtgccaaaca   3900

gaaagccaac cagcagcgtc agcagcagca gctgccacag cagcagcagc agcagccgcc   3960

acagcagccg ccacagcagc cacaacagca ggactctgtg tgggggatga accacagtac   4020

actccattca gtatttcaga ccaatcaaag caacaaccaa caatccaatt ttgaggctgt   4080

gcagagtggc aagaagaaga aaaagcagaa gatggtccga gcagatccca gtttattagg   4140

attttcagtc aatgcatcat cggagcgact caacatgggt gaaatcgaga cgttggatga   4200

ctactgagca cctgccagtg gactggccat ccctctcctg tctgccgact atggagtctc   4260

cacctttgga cacaacactt actcaccatt tactctttat cactctgcaa caaatcacag   4320

aaccgatcat ctcaggcttt ttcttctggc cctttgtgtc caagattctt taatccattt   4380

ttgttggtga acatctcaga ctatagataa gtggactgga ccctgtgtct tgggggtggc   4440

agttgggatt actccccaac aaggctgatt ttaggcagca tgtgttcact gtgctgtgat   4500

ttcatctact gtctcccaga aagtgtgttg ggatcggcca ttagcagctt gctttctctt   4560

gtcacttttt ttcttctatt ttgttttttc ttcttctttt tccccccatc agggcaaatg   4620

gtctaactgg tgcaatcatg aagagagtta atggttaaca gacattggcc aataacaaaa   4680

caccccatgg actgtgactc gagtatccaa caggcagtca gagctctccc ggtctgaaag   4740

ttgcattgcc actgctaact ttgggattgc atcagagagg ccctgagtgg ggttgagatg   4800

aggttggttt ggtttgatgt tacacactcc tcacctgttc tttctgagtg tcctttctct   4860

gaaaggattt atgtttttct tcgttagata gtgacttctg agcaagctga tctcccctgg   4920

catgctccaa cctgattgga caaaggaagc tctatggcct gggagagaga ctattcttaa   4980

tttttctttc ttacaaaaac tgatttttcc cataaatatt tttacttcag aggactagga   5040

ccattttgtt ttgggccctt ctgctgaaaa tttgtctcgt ttaagaggca gctagaatct   5100

ttaccatatg tatgaatttg tataatttca tttttggata gggataaact tttgcttctg   5160

ataaaagcct ggaatttcat ctggtcctca gagcattgcg tgtgtgtctt gctgtagccc   5220

ggaaaaggtt ttgtgtaaag attctgggat ggcaagttgt ttgccttttc tgaaaagaga   5280

acatacagaa cctgtccatc tttaagacct tcatccatgg aatctactat acaggaggat   5340

gcagtgggct ggaggggatg ggcgaaaatg ggagcaggaa gcctggcctg gcttctggtc   5400

atggcctcct aaaaccttaa acttcaagta gaaatgtact caagccctat ttataaacaa   5460

atacttttcc tgcctccacc aaacccctac agaacatcac ctggaattgc cactcacact   5520

gggttggagt cattgggcag ctgtgcctgt gcgagaggtg ctgtggtctg ggcagcccct   5580

ggaaaagcac ctttgctgcc tgtcattgtt gcctgaagaa ggctggagtt gctctgagag   5640

cagtttgggt ttggagtatt atatttggct tctattttta ttattttgga tcaccattct   5700

ccctatccct tcttgcctcc ctcccttcta aacatgtgta ataactatac agagactgct   5760

acaaaattgt atatagtttt tggatcaaat agcatgaggg gagaggaaac cattaaaagt   5820

tggggctcct actctccttt gctttgtaaa ttcaaaagtt gggggtgggt aagagggata   5880

gttaaaatgt ttacaaaact ttaggctccc tcggaacttt tgccagtgtg gaggaaaata   5940

aaaaagaact taaataaaat ctgattgtat tct                                5973


<210>  58
<211>  1321
<212>  PRT
<213>  Homosapiens

<400>  58

Met Ala Ala Glu Thr Gln Thr Leu Asn Phe Gly Pro Glu Trp Leu Arg 
1               5                   10                  15      


Ala Leu Ser Ser Gly Gly Ser Ile Thr Ser Pro Pro Leu Ser Pro Ala 
            20                  25                  30          


Leu Pro Lys Tyr Lys Leu Ala Asp Tyr Arg Tyr Gly Arg Glu Glu Met 
        35                  40                  45              


Leu Ala Leu Phe Leu Lys Asp Asn Lys Ile Pro Ser Asp Leu Leu Asp 
    50                  55                  60                  


Lys Glu Phe Leu Pro Ile Leu Gln Glu Glu Pro Leu Pro Pro Leu Ala 
65                  70                  75                  80  


Leu Val Pro Phe Thr Glu Glu Glu Gln Arg Asn Phe Ser Met Ser Val 
                85                  90                  95      


Asn Ser Ala Ala Val Leu Arg Leu Thr Gly Arg Gly Gly Gly Gly Thr 
            100                 105                 110         


Val Val Gly Ala Pro Arg Gly Arg Ser Ser Ser Arg Gly Arg Gly Arg 
        115                 120                 125             


Gly Arg Gly Glu Cys Gly Phe Tyr Gln Arg Ser Phe Asp Glu Val Glu 
    130                 135                 140                 


Gly Val Phe Gly Arg Gly Gly Gly Arg Glu Met His Arg Ser Gln Ser 
145                 150                 155                 160 


Trp Glu Glu Arg Gly Asp Arg Arg Phe Glu Lys Pro Gly Arg Lys Asp 
                165                 170                 175     


Val Gly Lys Lys Asn Gly Tyr Tyr Cys Met Tyr Ser Pro Val Leu Leu 
            180                 185                 190         


Leu Gly Gln Pro Leu Cys Gln Gly Arg Pro Asn Phe Glu Glu Gly Gly 
        195                 200                 205             


Pro Thr Ser Val Gly Arg Lys His Glu Phe Ile Arg Ser Glu Ser Glu 
    210                 215                 220                 


Asn Trp Arg Ile Phe Arg Glu Glu Gln Asn Gly Glu Asp Glu Asp Gly 
225                 230                 235                 240 


Gly Trp Arg Leu Ala Gly Ser Arg Arg Asp Gly Glu Arg Trp Arg Pro 
                245                 250                 255     


His Ser Pro Asp Gly Pro Arg Ser Ala Gly Trp Arg Glu His Met Glu 
            260                 265                 270         


Arg Arg Arg Arg Phe Glu Phe Asp Phe Arg Asp Arg Asp Asp Glu Arg 
        275                 280                 285             


Gly Tyr Arg Arg Val Arg Ser Gly Ser Gly Ser Ile Asp Asp Asp Arg 
    290                 295                 300                 


Asp Ser Leu Pro Glu Trp Cys Leu Glu Asp Ala Glu Glu Glu Met Gly 
305                 310                 315                 320 


Thr Phe Asp Ser Ser Gly Ala Phe Leu Ser Leu Lys Lys Val Gln Lys 
                325                 330                 335     


Glu Pro Ile Pro Glu Glu Gln Glu Met Asp Phe Arg Pro Val Asp Glu 
            340                 345                 350         


Gly Glu Glu Cys Ser Asp Ser Glu Gly Ser His Asn Glu Glu Ala Lys 
        355                 360                 365             


Glu Pro Asp Lys Thr Asn Lys Lys Glu Gly Glu Lys Thr Asp Arg Val 
    370                 375                 380                 


Gly Val Glu Ala Ser Glu Glu Thr Pro Gln Thr Ser Ser Ser Ser Ala 
385                 390                 395                 400 


Arg Pro Gly Thr Pro Ser Asp His Gln Ser Gln Glu Ala Ser Gln Phe 
                405                 410                 415     


Glu Arg Lys Asp Glu Pro Lys Thr Glu Gln Thr Glu Lys Ala Glu Glu 
            420                 425                 430         


Glu Thr Arg Met Glu Asn Ser Leu Pro Ala Lys Val Pro Ser Arg Gly 
        435                 440                 445             


Asp Glu Met Val Ala Asp Val Gln Gln Pro Leu Ser Gln Ile Pro Ser 
    450                 455                 460                 


Asp Thr Ala Ser Pro Leu Leu Ile Leu Pro Pro Pro Val Pro Asn Pro 
465                 470                 475                 480 


Ser Pro Thr Leu Arg Pro Val Glu Thr Pro Val Val Gly Ala Pro Gly 
                485                 490                 495     


Met Gly Ser Val Ser Thr Glu Pro Asp Asp Glu Glu Gly Leu Lys His 
            500                 505                 510         


Leu Glu Gln Gln Ala Glu Lys Met Val Ala Tyr Leu Gln Asp Ser Ala 
        515                 520                 525             


Leu Asp Asp Glu Arg Leu Ala Ser Lys Leu Gln Glu His Arg Ala Lys 
    530                 535                 540                 


Gly Val Ser Ile Pro Leu Met His Glu Ala Met Gln Lys Trp Tyr Tyr 
545                 550                 555                 560 


Lys Asp Pro Gln Gly Glu Ile Gln Gly Pro Phe Asn Asn Gln Glu Met 
                565                 570                 575     


Ala Glu Trp Phe Gln Ala Gly Tyr Phe Thr Met Ser Leu Leu Val Lys 
            580                 585                 590         


Arg Ala Cys Asp Glu Ser Phe Gln Pro Leu Gly Asp Ile Met Lys Met 
        595                 600                 605             


Trp Gly Arg Val Pro Phe Ser Pro Gly Pro Ala Pro Pro Pro His Met 
    610                 615                 620                 


Gly Glu Leu Asp Gln Glu Arg Leu Thr Arg Gln Gln Glu Leu Thr Ala 
625                 630                 635                 640 


Leu Tyr Gln Met Gln His Leu Gln Tyr Gln Gln Phe Leu Ile Gln Gln 
                645                 650                 655     


Gln Tyr Ala Gln Val Leu Ala Gln Gln Gln Lys Ala Ala Leu Ser Ser 
            660                 665                 670         


Gln Gln Gln Gln Gln Leu Ala Leu Leu Leu Gln Gln Phe Gln Thr Leu 
        675                 680                 685             


Lys Met Arg Ile Ser Asp Gln Asn Ile Ile Pro Ser Val Thr Arg Ser 
    690                 695                 700                 


Val Ser Val Pro Asp Thr Gly Ser Ile Trp Glu Leu Gln Pro Thr Ala 
705                 710                 715                 720 


Ser Gln Pro Thr Val Trp Glu Gly Gly Ser Val Trp Asp Leu Pro Leu 
                725                 730                 735     


Asp Thr Thr Thr Pro Gly Pro Ala Leu Glu Gln Leu Gln Gln Leu Glu 
            740                 745                 750         


Lys Ala Lys Ala Ala Lys Leu Glu Gln Glu Arg Arg Glu Ala Glu Met 
        755                 760                 765             


Arg Ala Lys Arg Glu Glu Glu Glu Arg Lys Arg Gln Glu Glu Leu Arg 
    770                 775                 780                 


Arg Gln Gln Glu Glu Ile Leu Arg Arg Gln Gln Glu Glu Glu Arg Lys 
785                 790                 795                 800 


Arg Arg Glu Glu Glu Glu Leu Ala Arg Arg Lys Gln Glu Glu Ala Leu 
                805                 810                 815     


Arg Arg Gln Arg Glu Gln Glu Ile Ala Leu Arg Arg Gln Arg Glu Glu 
            820                 825                 830         


Glu Glu Arg Gln Gln Gln Glu Glu Ala Leu Arg Arg Leu Glu Glu Arg 
        835                 840                 845             


Arg Arg Glu Glu Glu Glu Arg Arg Lys Gln Glu Glu Leu Leu Arg Lys 
    850                 855                 860                 


Gln Glu Glu Glu Ala Ala Lys Trp Ala Arg Glu Glu Glu Glu Ala Gln 
865                 870                 875                 880 


Arg Arg Leu Glu Glu Asn Arg Leu Arg Met Glu Glu Glu Ala Ala Arg 
                885                 890                 895     


Leu Arg His Glu Glu Glu Glu Arg Lys Arg Lys Glu Leu Glu Val Gln 
            900                 905                 910         


Arg Gln Lys Glu Leu Met Arg Gln Arg Gln Gln Gln Gln Glu Ala Leu 
        915                 920                 925             


Arg Arg Leu Gln Gln Gln Gln Gln Gln Gln Gln Leu Ala Gln Met Lys 
    930                 935                 940                 


Leu Pro Ser Ser Ser Thr Trp Gly Gln Gln Ser Asn Thr Thr Ala Cys 
945                 950                 955                 960 


Gln Ser Gln Ala Thr Leu Ser Leu Ala Glu Ile Gln Lys Leu Glu Glu 
                965                 970                 975     


Glu Arg Glu Arg Gln Leu Arg Glu Glu Gln Arg Arg Gln Gln Arg Glu 
            980                 985                 990         


Leu Met Lys Ala Leu Gln Gln Gln  Gln Gln Gln Gln Gln  Gln Lys Leu 
        995                 1000                 1005             


Ser Gly  Trp Gly Asn Val Ser  Lys Pro Ser Gly Thr  Thr Lys Ser 
    1010                 1015                 1020             


Leu Leu  Glu Ile Gln Gln Glu  Glu Ala Arg Gln Met  Gln Lys Gln 
    1025                 1030                 1035             


Gln Gln  Gln Gln Gln Gln His  Gln Gln Pro Asn Arg  Ala Arg Asn 
    1040                 1045                 1050             


Asn Thr  His Ser Asn Leu His  Thr Ser Ile Gly Asn  Ser Val Trp 
    1055                 1060                 1065             


Gly Ser  Ile Asn Thr Gly Pro  Pro Asn Gln Trp Ala  Ser Asp Leu 
    1070                 1075                 1080             


Val Ser  Ser Ile Trp Ser Asn  Ala Asp Thr Lys Asn  Ser Asn Met 
    1085                 1090                 1095             


Gly Phe  Trp Asp Asp Ala Val  Lys Glu Val Gly Pro  Arg Asn Ser 
    1100                 1105                 1110             


Thr Asn  Lys Asn Lys Asn Asn  Ala Ser Leu Ser Lys  Ser Val Gly 
    1115                 1120                 1125             


Val Ser  Asn Arg Gln Asn Lys  Lys Val Glu Glu Glu  Glu Lys Leu 
    1130                 1135                 1140             


Leu Lys  Leu Phe Gln Gly Val  Asn Lys Ala Gln Asp  Gly Phe Thr 
    1145                 1150                 1155             


Gln Trp  Cys Glu Gln Met Leu  His Ala Leu Asn Thr  Ala Asn Asn 
    1160                 1165                 1170             


Leu Asp  Val Pro Thr Phe Val  Ser Phe Leu Lys Glu  Val Glu Ser 
    1175                 1180                 1185             


Pro Tyr  Glu Val His Asp Tyr  Ile Arg Ala Tyr Leu  Gly Asp Thr 
    1190                 1195                 1200             


Ser Glu  Ala Lys Glu Phe Ala  Lys Gln Phe Leu Glu  Arg Arg Ala 
    1205                 1210                 1215             


Lys Gln  Lys Ala Asn Gln Gln  Arg Gln Gln Gln Gln  Leu Pro Gln 
    1220                 1225                 1230             


Gln Gln  Gln Gln Gln Pro Pro  Gln Gln Pro Pro Gln  Gln Pro Gln 
    1235                 1240                 1245             


Gln Gln  Asp Ser Val Trp Gly  Met Asn His Ser Thr  Leu His Ser 
    1250                 1255                 1260             


Val Phe  Gln Thr Asn Gln Ser  Asn Asn Gln Gln Ser  Asn Phe Glu 
    1265                 1270                 1275             


Ala Val  Gln Ser Gly Lys Lys  Lys Lys Lys Gln Lys  Met Val Arg 
    1280                 1285                 1290             


Ala Asp  Pro Ser Leu Leu Gly  Phe Ser Val Asn Ala  Ser Ser Glu 
    1295                 1300                 1305             


Arg Leu  Asn Met Gly Glu Ile  Glu Thr Leu Asp Asp  Tyr 
    1310                 1315                 1320     


<210>  59
<211>  7924
<212>  DNA
<213>  Homosapiens

<400>  59
atcttgtgtt gttgaggctg aggactgact ggggttctga gactccctgt cccggaccgc     60

agattatagt gggaccagtc tcattaggtt gaatctacag cctatgttgg tgttaaccca    120

ggtctcttag agcgttaaaa ggatctgaac aaagtctgct caaatctcct gctgtgaacc    180

agcagaattt ttgaacaggt ttcttcacat ataaaaatct attgtaaaaa tacggaaaag    240

aatggcagcg gaaacgcaga cactgaactt tgggcctgaa tggctccgag ctctgtccag    300

tggtgggagt attacatccc ctcctctttc tccagcattg ccgaagtata aattagcaga    360

ttatcgttac ggcagagaag aaatgttagc acttttcctt aaagacaaca agataccttc    420

agaccttctg gataaagaat ttctgcctat cctccaggag gaaccccttc caccattggc    480

tctggtaccc tttacagaag aagaacagag aaacttttcc atgtctgtaa atagtgctgc    540

tgtcctgcga ttgacaggac gaggaggagg aggaacagtg gtgggggctc ctagaggtcg    600

aagttcttca agagggcgag gcagaggcag aggtgaatgt ggtttctacc aaagaagttt    660

tgatgaagta gagggtgttt ttggtcgagg aggtggcaga gaaatgcata gatcgcagag    720

ctgggaggaa aggggtgaca gacgttttga aaaaccagga cgaaaagatg taggaaagaa    780

gaatggatat tattgcatgt actcaccagt tcttttgctg ggtcagcctt tatgccaagg    840

gagaccaaat tttgaggaag gtggaccaac atcagtaggg agaaagcatg aatttatacg    900

ctcagaaagt gaaaattggc gcatctttag agaggaacaa aatggagaag atgaagatgg    960

aggttggcga ctagctggat caaggaggga tggagagagg tggcgacctc acagtcctga   1020

tggccctcgt tctgcaggct ggcgggaaca catggaacga cgtcggaggt ttgagtttga   1080

ttttcgagat agagatgatg aacggggtta ccgaagggtt cgctctggca gtgggagcat   1140

agatgatgac agggatagct tgcccgaatg gtgcttagag gatgctgaag aagaaatggg   1200

tacatttgac tcatctggag cattcctttc tctaaaaaaa gtacagaaag agcctattcc   1260

agaagagcag gagatggact tccggcctgt ggacgaaggg gaggagtgct ctgactctga   1320

gggtagccat aatgaagagg ccaaagaacc cgataagaca aataagaaag aaggagagaa   1380

aacagataga gtaggagttg aagctagtga ggaaactccc cagacctcat catcatctgc   1440

tagaccaggt actccttcag accatcagtc tcaggaagca tcacagtttg agaggaaaga   1500

tgaaccaaaa actgagcaaa cggaaaaagc tgaagaggag actcggatgg aaaatagtct   1560

accagccaaa gtgcccagca gaggggatga aatggttgct gatgtccagc agcccctgtc   1620

gcagattcct tcagatacag cctctcctct tctcatactt ccacctcctg ttcccaatcc   1680

tagtcctact ctccggccag ttgaaacacc agttgtaggt gctcctggta tgggcagtgt   1740

ttccacagaa cctgatgatg aagaaggtct caaacatttg gagcagcaag ctgagaaaat   1800

ggtggcttat ctccaagaca gtgcactaga tgatgaaaga ttggcatcaa aactgcaaga   1860

gcacagagct aaaggagtgt cgattccatt gatgcatgaa gcaatgcaga agtggtatta   1920

caaagatcct cagggagaaa ttcaaggtcc cttcaataat caggagatgg cagaatggtt   1980

tcaggcgggc tattttacta tgtctttatt ggtgaagaga gcgtgtgatg aaagcttcca   2040

acctcttggc gatatcatga aaatgtgggg aagggttccc ttttctccag gtccagctcc   2100

ccctcctcat atgggagagc tggaccagga acgactgacc aggcagcaag aactcacagc   2160

cttataccag atgcagcacc tgcagtacca gcagttttta atacaacaac aatatgcaca   2220

ggttttggcc caacagcaga aagcagcact gtcttcccag cagcagcagc agttggcact   2280

tcttcttcaa cagtttcaga ccttgaagat gagaatatct gatcagaaca tcattccctc   2340

agtaactagg tctgtgtccg tgccagatac tggctctatc tgggagcttc agccaacagc   2400

ttcacagcct acagtttggg aaggtggtag tgtatgggat cttcctctgg acaccacgac   2460

accaggccct gccctggaac agcttcagca gctagagaag gccaaagctg caaagctaga   2520

gcaagagaga agagaggcag aaatgagggc aaaacgggaa gaggaagagc gaaagaggca   2580

ggaagaactc cgaagacaac aggaggaaat tcttcggcga cagcaggaag aagaaaggaa   2640

aaggcgagag gaagaagaac ttgcccgaag gaaacaggaa gaggctctgc gtcgccagcg   2700

ggagcaagaa attgcattaa ggcgacagcg agaagaggaa gaaagacagc agcaagaaga   2760

agctcttaga agactggaag agaggagaag agaagaggaa gaaaggcgga agcaggaaga   2820

attgttacgc aaacaggaag aggaggctgc aaaatgggcc cgggaagaag aagaagccca   2880

gcgtcgatta gaggagaacc ggctgcggat ggaagaggag gcagccagac tccggcatga   2940

ggaagaagaa cggaagagaa aggagctgga ggtccagcgg cagaaggagt taatgcgcca   3000

gaggcagcag cagcaagagg ctctccggag gttgcagcag cagcagcagc aacaacagct   3060

ggcgcagatg aagcttcctt cttcttcaac gtggggccag cagtccaata caacagcatg   3120

tcagtcccag gccacgctgt cgttggctga aatccaaaaa ctagaggaag aacgagaacg   3180

gcagcttcga gaagagcaaa ggcgccagca gagggagttg atgaaagctc ttcagcagca   3240

gcagcaacag caacagcaga aactctcagg ttgggggaat gtcagcaaac cttcaggtac   3300

cacgaaatct cttctggaga tccagcagga agaggccagg caaatgcaaa agcagcagca   3360

gcagcagcag caacaccagc aaccaaacag agctcgtaac aatacgcatt ccaacctgca   3420

caccagcatt gggaattctg tttggggctc tataaatact ggtcctccta accagtgggc   3480

atctgaccta gtcagtagta tttggagtaa tgctgacact aaaaactcca acatgggatt   3540

ctgggatgat gcagtgaaag aggtgggacc taggaattca acaaataaaa ataaaaacaa   3600

cgccagtctc agtaaatctg taggtgtgtc taaccggcag aataagaaag tagaagaaga   3660

agaaaagttg ctgaagctct ttcagggagt aaataaagcc caagatggat ttacgcagtg   3720

gtgtgaacag atgcttcatg cccttaatac ggcaaataac ttggatgttc ccacatttgt   3780

ttctttcctg aaagaagtag aatctcctta tgaggtccat gattatatca gggcctattt   3840

aggagatact tctgaggcca aggagtttgc caagcagttc cttgagcgcc gtgccaaaca   3900

gaaagccaac cagcagcgtc agcagcagca gctgccacag cagcagcagc agcagccgcc   3960

acagcagccg ccacagcagc cacaacagca ggactctgtg tgggggatga accacagtac   4020

actccattca gtatttcaga ccaatcaaag caacaaccaa caatccaatt ttgaggctgt   4080

gcagagtggc aagaagaaga aaaagcagaa gatggtccga gcagatccca gtttattagg   4140

attttcagtc aatgcatcat cggagcgact caacatgggt gaaatcgaga cgttggatga   4200

ctactgagca cctgccagtg gactggccat ccctctcctg tctgccgact atggagtctc   4260

cacctttgga cacaacactt actcaccatt tactctttat cactctgcaa caaatcacag   4320

aaccgatcat ctcaggcttt ttcttctggc cctttgtgtc caagattctt taatccattt   4380

ttgttggtga acatctcaga ctatagataa gtggactgga ccctgtgtct tgggggtggc   4440

agttgggatt actccccaac aaggctgatt ttaggcagca tgtgttcact gtgctgtgat   4500

ttcatctact gtctcccaga aagtgtgttg ggatcggcca ttagcagctt gctttctctt   4560

gtcacttttt ttcttctatt ttgttttttc ttcttctttt tccccccatc agggcaaatg   4620

gtctaactgg tgcaatcatg aagagagtta atggttaaca gacattggcc aataacaaaa   4680

caccccatgg actgtgactc gagtatccaa caggcagtca gagctctccc ggtctgaaag   4740

ttgcattgcc actgctaact ttgggattgc atcagagagg ccctgagtgg ggttgagatg   4800

aggttggttt ggtttgatgt tacacactcc tcacctgttc tttctgagtg tcctttctct   4860

gaaaggattt atgtttttct tcgttagata gtgacttctg agcaagctga tctcccctgg   4920

catgctccaa cctgattgga caaaggaagc tctatggcct gggagagaga ctattcttaa   4980

tttttctttc ttacaaaaac tgatttttcc cataaatatt tttacttcag aggactagga   5040

ccattttgtt ttgggccctt ctgctgaaaa tttgtctcgt ttaagaggca gctagaatct   5100

ttaccatatg tatgaatttg tataatttca tttttggata gggataaact tttgcttctg   5160

ataaaagcct ggaatttcat ctggtcctca gagcattgcg tgtgtgtctt gctgtagccc   5220

ggaaaaggtt ttgtgtaaag attctgggat ggcaagttgt ttgccttttc tgaaaagaga   5280

acatacagaa cctgtccatc tttaagacct tcatccatgg aatctactat acaggaggat   5340

gcagtgggct ggaggggatg ggcgaaaatg ggagcaggaa gcctggcctg gcttctggtc   5400

atggcctcct aaaaccttaa acttcaagta gaaatgtact caagccctat ttataaacaa   5460

atacttttcc tgcctccacc aaacccctac agaacatcac ctggaattgc cactcacact   5520

gggttggagt cattgggcag ctgtgcctgt gcgagaggtg ctgtggtctg ggcagcccct   5580

ggaaaagcac ctttgctgcc tgtcattgtt gcctgaagaa ggctggagtt gctctgagag   5640

cagtttgggt ttggagtatt atatttggct tctattttta ttattttgga tcaccattct   5700

ccctatccct tcttgcctcc ctcccttcta aacatgtgta ataactatac agagactgct   5760

acaaaattgt atatagtttt tggatcaaat agcatgaggg gagaggaaac cattaaaagt   5820

tggggctcct actctccttt gctttgtaaa ttcaaaagtt gggggtgggt aagagggata   5880

gttaaaatgt ttacaaaact ttaggctccc tcggaacttt tgccagtgtg gaggaaaata   5940

aaaaagaact taaataaaat ctgattgtat tctatctgag tgcacctctt gtactcacct   6000

ttatggaggc tgagttctgc actaaactgt tcctcttggt accatggaaa agctccaagc   6060

acccaagaca tggaggcagc catggcttct ttctctgcca gaccacgtag cactggctgg   6120

ttctgtattt gagaatgtag aggtcaaggc agatgtcggt aagtttgacc aaatatcttt   6180

tctctttttg actctccctt tctgctaaca tgtggatcag ctcctgccct cataccgcag   6240

acacacccac tctgaacaca cccctccaga gcttgcccac accttcccaa ctagactctg   6300

tgtgtgtatt caggaaaaat gaaaataaat ttttaaaaat tgggagtgga atgggcagat   6360

tagggggaac aaagtcattt tggtcatgga acatccattt gcttaaccaa ggagacttgc   6420

ttctatctga ggaatttccc acttagtaga aagaaacact cttccctggg aatgtttgtt   6480

tctgtctctc tcaatgctac tctctttcat attctcattt gctcaccctt tcacttagag   6540

ccaccgtttt ctcatcccat tctatgaact tatttccaaa ttctcctaac tattcctgag   6600

ttttgaagta tttgttttgt accctctctg cttccggttt tttgtttggt tggctttttt   6660

ggagataggg tcttgtgatg ttgcccacac tggtctcgag cccctgggct caagtgatcc   6720

tcccgcctca gcctcctaaa tatctaggac tacaggtgtg tgccaccatg cccagctcca   6780

gttttgttgg ttgatttgtt taaattcaga gatttaaaaa catcccagac aagacagttt   6840

gattatggag actgtcccca agcagattgg tgtgctggtg gctgctgtgc ataacagatt   6900

ccctccagat tggcttacaa cagctacttc attctgtggg tcaggaattt ggatagggct   6960

cagctgggtg gtggttctcc tggggtattc tttggttgtg gtcagatgtc ttccagggca   7020

tcattcctat gaaggcttaa tgaattaggc aagctgtcca agatggctca ctcgtgtaat   7080

gacagttgac gttggctgta ggctgggaac tcagctgggt tgatgactgg aggagcttat   7140

gtgtgtcgtc tccggaatgg cagcttcaga ggagttgaac ttaagtggtg attggcttcc   7200

cccagagaac caggcagaag ctgtgttacc tttttgagct cttagctcag gagtcacata   7260

gagtcacttc tgtgacactg tgttgcatca aagtagtcac aaacccactc agattcaaga   7320

gaagggagca tggccctctc cctgcaaccc cctccccccc cgccttgatg aaaggagtga   7380

caaggtcaca ttggagaaga gcttgtgggg tgggagatat tatagccatt tttgggaaat   7440

atctgcataa aatgagttta tgcatacatg aaggacttta ttttcattgg ctttaagttg   7500

agggtttttg tttttgtttt tgtattggag atgggttctt actatgttgc ccaggctggt   7560

ctcaaacccc tgggctcaag tgatcctgtt gcctcagcct cccaagtagc tgggactaca   7620

gctatgtgcc agtgcaccca gcttgttttt tttaaatttt aggatagata atggtacttc   7680

tggctttatt taaataattt ttttagggaa accattgtat ttatacatgc atatattttt   7740

atatatacaa atatgtatat aaaagtatat gttttacatt ttcaatatat atataatata   7800

tacatatatg ttatatacgt atatatattg caccctactt taaaattgac tgataacaaa   7860

attggtaatt ttgtataaaa tgcccaactg tgcattatta ataaaagtat gtgaatgact   7920

ctaa                                                                7924


<210>  60
<211>  1321
<212>  PRT
<213>  Homosapiens

<400>  60

Met Ala Ala Glu Thr Gln Thr Leu Asn Phe Gly Pro Glu Trp Leu Arg 
1               5                   10                  15      


Ala Leu Ser Ser Gly Gly Ser Ile Thr Ser Pro Pro Leu Ser Pro Ala 
            20                  25                  30          


Leu Pro Lys Tyr Lys Leu Ala Asp Tyr Arg Tyr Gly Arg Glu Glu Met 
        35                  40                  45              


Leu Ala Leu Phe Leu Lys Asp Asn Lys Ile Pro Ser Asp Leu Leu Asp 
    50                  55                  60                  


Lys Glu Phe Leu Pro Ile Leu Gln Glu Glu Pro Leu Pro Pro Leu Ala 
65                  70                  75                  80  


Leu Val Pro Phe Thr Glu Glu Glu Gln Arg Asn Phe Ser Met Ser Val 
                85                  90                  95      


Asn Ser Ala Ala Val Leu Arg Leu Thr Gly Arg Gly Gly Gly Gly Thr 
            100                 105                 110         


Val Val Gly Ala Pro Arg Gly Arg Ser Ser Ser Arg Gly Arg Gly Arg 
        115                 120                 125             


Gly Arg Gly Glu Cys Gly Phe Tyr Gln Arg Ser Phe Asp Glu Val Glu 
    130                 135                 140                 


Gly Val Phe Gly Arg Gly Gly Gly Arg Glu Met His Arg Ser Gln Ser 
145                 150                 155                 160 


Trp Glu Glu Arg Gly Asp Arg Arg Phe Glu Lys Pro Gly Arg Lys Asp 
                165                 170                 175     


Val Gly Lys Lys Asn Gly Tyr Tyr Cys Met Tyr Ser Pro Val Leu Leu 
            180                 185                 190         


Leu Gly Gln Pro Leu Cys Gln Gly Arg Pro Asn Phe Glu Glu Gly Gly 
        195                 200                 205             


Pro Thr Ser Val Gly Arg Lys His Glu Phe Ile Arg Ser Glu Ser Glu 
    210                 215                 220                 


Asn Trp Arg Ile Phe Arg Glu Glu Gln Asn Gly Glu Asp Glu Asp Gly 
225                 230                 235                 240 


Gly Trp Arg Leu Ala Gly Ser Arg Arg Asp Gly Glu Arg Trp Arg Pro 
                245                 250                 255     


His Ser Pro Asp Gly Pro Arg Ser Ala Gly Trp Arg Glu His Met Glu 
            260                 265                 270         


Arg Arg Arg Arg Phe Glu Phe Asp Phe Arg Asp Arg Asp Asp Glu Arg 
        275                 280                 285             


Gly Tyr Arg Arg Val Arg Ser Gly Ser Gly Ser Ile Asp Asp Asp Arg 
    290                 295                 300                 


Asp Ser Leu Pro Glu Trp Cys Leu Glu Asp Ala Glu Glu Glu Met Gly 
305                 310                 315                 320 


Thr Phe Asp Ser Ser Gly Ala Phe Leu Ser Leu Lys Lys Val Gln Lys 
                325                 330                 335     


Glu Pro Ile Pro Glu Glu Gln Glu Met Asp Phe Arg Pro Val Asp Glu 
            340                 345                 350         


Gly Glu Glu Cys Ser Asp Ser Glu Gly Ser His Asn Glu Glu Ala Lys 
        355                 360                 365             


Glu Pro Asp Lys Thr Asn Lys Lys Glu Gly Glu Lys Thr Asp Arg Val 
    370                 375                 380                 


Gly Val Glu Ala Ser Glu Glu Thr Pro Gln Thr Ser Ser Ser Ser Ala 
385                 390                 395                 400 


Arg Pro Gly Thr Pro Ser Asp His Gln Ser Gln Glu Ala Ser Gln Phe 
                405                 410                 415     


Glu Arg Lys Asp Glu Pro Lys Thr Glu Gln Thr Glu Lys Ala Glu Glu 
            420                 425                 430         


Glu Thr Arg Met Glu Asn Ser Leu Pro Ala Lys Val Pro Ser Arg Gly 
        435                 440                 445             


Asp Glu Met Val Ala Asp Val Gln Gln Pro Leu Ser Gln Ile Pro Ser 
    450                 455                 460                 


Asp Thr Ala Ser Pro Leu Leu Ile Leu Pro Pro Pro Val Pro Asn Pro 
465                 470                 475                 480 


Ser Pro Thr Leu Arg Pro Val Glu Thr Pro Val Val Gly Ala Pro Gly 
                485                 490                 495     


Met Gly Ser Val Ser Thr Glu Pro Asp Asp Glu Glu Gly Leu Lys His 
            500                 505                 510         


Leu Glu Gln Gln Ala Glu Lys Met Val Ala Tyr Leu Gln Asp Ser Ala 
        515                 520                 525             


Leu Asp Asp Glu Arg Leu Ala Ser Lys Leu Gln Glu His Arg Ala Lys 
    530                 535                 540                 


Gly Val Ser Ile Pro Leu Met His Glu Ala Met Gln Lys Trp Tyr Tyr 
545                 550                 555                 560 


Lys Asp Pro Gln Gly Glu Ile Gln Gly Pro Phe Asn Asn Gln Glu Met 
                565                 570                 575     


Ala Glu Trp Phe Gln Ala Gly Tyr Phe Thr Met Ser Leu Leu Val Lys 
            580                 585                 590         


Arg Ala Cys Asp Glu Ser Phe Gln Pro Leu Gly Asp Ile Met Lys Met 
        595                 600                 605             


Trp Gly Arg Val Pro Phe Ser Pro Gly Pro Ala Pro Pro Pro His Met 
    610                 615                 620                 


Gly Glu Leu Asp Gln Glu Arg Leu Thr Arg Gln Gln Glu Leu Thr Ala 
625                 630                 635                 640 


Leu Tyr Gln Met Gln His Leu Gln Tyr Gln Gln Phe Leu Ile Gln Gln 
                645                 650                 655     


Gln Tyr Ala Gln Val Leu Ala Gln Gln Gln Lys Ala Ala Leu Ser Ser 
            660                 665                 670         


Gln Gln Gln Gln Gln Leu Ala Leu Leu Leu Gln Gln Phe Gln Thr Leu 
        675                 680                 685             


Lys Met Arg Ile Ser Asp Gln Asn Ile Ile Pro Ser Val Thr Arg Ser 
    690                 695                 700                 


Val Ser Val Pro Asp Thr Gly Ser Ile Trp Glu Leu Gln Pro Thr Ala 
705                 710                 715                 720 


Ser Gln Pro Thr Val Trp Glu Gly Gly Ser Val Trp Asp Leu Pro Leu 
                725                 730                 735     


Asp Thr Thr Thr Pro Gly Pro Ala Leu Glu Gln Leu Gln Gln Leu Glu 
            740                 745                 750         


Lys Ala Lys Ala Ala Lys Leu Glu Gln Glu Arg Arg Glu Ala Glu Met 
        755                 760                 765             


Arg Ala Lys Arg Glu Glu Glu Glu Arg Lys Arg Gln Glu Glu Leu Arg 
    770                 775                 780                 


Arg Gln Gln Glu Glu Ile Leu Arg Arg Gln Gln Glu Glu Glu Arg Lys 
785                 790                 795                 800 


Arg Arg Glu Glu Glu Glu Leu Ala Arg Arg Lys Gln Glu Glu Ala Leu 
                805                 810                 815     


Arg Arg Gln Arg Glu Gln Glu Ile Ala Leu Arg Arg Gln Arg Glu Glu 
            820                 825                 830         


Glu Glu Arg Gln Gln Gln Glu Glu Ala Leu Arg Arg Leu Glu Glu Arg 
        835                 840                 845             


Arg Arg Glu Glu Glu Glu Arg Arg Lys Gln Glu Glu Leu Leu Arg Lys 
    850                 855                 860                 


Gln Glu Glu Glu Ala Ala Lys Trp Ala Arg Glu Glu Glu Glu Ala Gln 
865                 870                 875                 880 


Arg Arg Leu Glu Glu Asn Arg Leu Arg Met Glu Glu Glu Ala Ala Arg 
                885                 890                 895     


Leu Arg His Glu Glu Glu Glu Arg Lys Arg Lys Glu Leu Glu Val Gln 
            900                 905                 910         


Arg Gln Lys Glu Leu Met Arg Gln Arg Gln Gln Gln Gln Glu Ala Leu 
        915                 920                 925             


Arg Arg Leu Gln Gln Gln Gln Gln Gln Gln Gln Leu Ala Gln Met Lys 
    930                 935                 940                 


Leu Pro Ser Ser Ser Thr Trp Gly Gln Gln Ser Asn Thr Thr Ala Cys 
945                 950                 955                 960 


Gln Ser Gln Ala Thr Leu Ser Leu Ala Glu Ile Gln Lys Leu Glu Glu 
                965                 970                 975     


Glu Arg Glu Arg Gln Leu Arg Glu Glu Gln Arg Arg Gln Gln Arg Glu 
            980                 985                 990         


Leu Met Lys Ala Leu Gln Gln Gln  Gln Gln Gln Gln Gln  Gln Lys Leu 
        995                 1000                 1005             


Ser Gly  Trp Gly Asn Val Ser  Lys Pro Ser Gly Thr  Thr Lys Ser 
    1010                 1015                 1020             


Leu Leu  Glu Ile Gln Gln Glu  Glu Ala Arg Gln Met  Gln Lys Gln 
    1025                 1030                 1035             


Gln Gln  Gln Gln Gln Gln His  Gln Gln Pro Asn Arg  Ala Arg Asn 
    1040                 1045                 1050             


Asn Thr  His Ser Asn Leu His  Thr Ser Ile Gly Asn  Ser Val Trp 
    1055                 1060                 1065             


Gly Ser  Ile Asn Thr Gly Pro  Pro Asn Gln Trp Ala  Ser Asp Leu 
    1070                 1075                 1080             


Val Ser  Ser Ile Trp Ser Asn  Ala Asp Thr Lys Asn  Ser Asn Met 
    1085                 1090                 1095             


Gly Phe  Trp Asp Asp Ala Val  Lys Glu Val Gly Pro  Arg Asn Ser 
    1100                 1105                 1110             


Thr Asn  Lys Asn Lys Asn Asn  Ala Ser Leu Ser Lys  Ser Val Gly 
    1115                 1120                 1125             


Val Ser  Asn Arg Gln Asn Lys  Lys Val Glu Glu Glu  Glu Lys Leu 
    1130                 1135                 1140             


Leu Lys  Leu Phe Gln Gly Val  Asn Lys Ala Gln Asp  Gly Phe Thr 
    1145                 1150                 1155             


Gln Trp  Cys Glu Gln Met Leu  His Ala Leu Asn Thr  Ala Asn Asn 
    1160                 1165                 1170             


Leu Asp  Val Pro Thr Phe Val  Ser Phe Leu Lys Glu  Val Glu Ser 
    1175                 1180                 1185             


Pro Tyr  Glu Val His Asp Tyr  Ile Arg Ala Tyr Leu  Gly Asp Thr 
    1190                 1195                 1200             


Ser Glu  Ala Lys Glu Phe Ala  Lys Gln Phe Leu Glu  Arg Arg Ala 
    1205                 1210                 1215             


Lys Gln  Lys Ala Asn Gln Gln  Arg Gln Gln Gln Gln  Leu Pro Gln 
    1220                 1225                 1230             


Gln Gln  Gln Gln Gln Pro Pro  Gln Gln Pro Pro Gln  Gln Pro Gln 
    1235                 1240                 1245             


Gln Gln  Asp Ser Val Trp Gly  Met Asn His Ser Thr  Leu His Ser 
    1250                 1255                 1260             


Val Phe  Gln Thr Asn Gln Ser  Asn Asn Gln Gln Ser  Asn Phe Glu 
    1265                 1270                 1275             


Ala Val  Gln Ser Gly Lys Lys  Lys Lys Lys Gln Lys  Met Val Arg 
    1280                 1285                 1290             


Ala Asp  Pro Ser Leu Leu Gly  Phe Ser Val Asn Ala  Ser Ser Glu 
    1295                 1300                 1305             


Arg Leu  Asn Met Gly Glu Ile  Glu Thr Leu Asp Asp  Tyr 
    1310                 1315                 1320     


<210>  61
<211>  5764
<212>  DNA
<213>  Homosapiens

<400>  61
gttgttgagg ctgaggactg actggggttc tgagactccc tgtcccggac cgcaggtttc     60

ttcacatata aaaatctatt gtaaaaatac ggaaaagaat ggcagcggaa acgcagacac    120

tgaactttgg gcctgaatgg ctccgagctc tgtccagtgg tgggagtatt acatcccctc    180

ctctttctcc agcattgccg aagtataaat tagcagatta tcgttacggc agagaagaaa    240

tgttagcact tttccttaaa gacaacaaga taccttcaga ccttctggat aaagaatttc    300

tgcctatcct ccaggaggaa ccccttccac cattggctct ggtacccttt acagaagaag    360

aacagagaaa cttttccatg tctgtaaata gtgctgctgt cctgcgattg acaggacgag    420

gaggaggagg aacagtggtg ggggctccta gaggtcgaag ttcttcaaga gggcgaggca    480

gaggcagagg tgaatgtggt ttctaccaaa gaagttttga tgaagtagag ggtgtttttg    540

gtcgaggagg tggcagagaa atgcatagat cgcagagctg ggaggaaagg ggtgacagac    600

gttttgaaaa accaggacga aaagatgtag ggagaccaaa ttttgaggaa ggtggaccaa    660

catcagtagg gagaaagcat gaatttatac gctcagaaag tgaaaattgg cgcatcttta    720

gagaggaaca aaatggagaa gatgaagatg gaggttggcg actagctgga tcaaggaggg    780

atggagagag gtggcgacct cacagtcctg atggccctcg ttctgcaggc tggcgggaac    840

acatggaacg acgtcggagg tttgagtttg attttcgaga tagagatgat gaacggggtt    900

accgaagggt tcgctctggc agtgggagca tagatgatga cagggatagc ttgcccgaat    960

ggtgcttaga ggatgctgaa gaagaaatgg gtacatttga ctcatctgga gcattccttt   1020

ctctaaaaaa agtacagaaa gagcctattc cagaagagca ggagatggac ttccggcctg   1080

tggacgaagg ggaggagtgc tctgactctg agggtagcca taatgaagag gccaaagaac   1140

ccgataagac aaataagaaa gaaggagaga aaacagatag agtaggagtt gaagctagtg   1200

aggaaactcc ccagacctca tcatcatctg ctagaccagg tactccttca gaccatcagt   1260

ctcaggaagc atcacagttt gagaggaaag atgaaccaaa aactgagcaa acggaaaaag   1320

ctgaagagga gactcggatg gaaaatagtc taccagccaa agtgcccagc agaggggatg   1380

aaatggttgc tgatgtccag cagcccctgt cgcagattcc ttcagataca gcctctcctc   1440

ttctcatact tccacctcct gttcccaatc ctagtcctac tctccggcca gttgaaacac   1500

cagttgtagg tgctcctggt atgggcagtg tttccacaga acctgatgat gaagaaggtc   1560

tcaaacattt ggagcagcaa gctgagaaaa tggtggctta tctccaagac agtgcactag   1620

atgatgaaag attggcatca aaactgcaag agcacagagc taaaggagtg tcgattccat   1680

tgatgcatga agcaatgcag aagtggtatt acaaagatcc tcagggagaa attcaaggtc   1740

ccttcaataa tcaggagatg gcagaatggt ttcaggcggg ctattttact atgtctttat   1800

tggtgaagag agcgtgtgat gaaagcttcc aacctcttgg cgatatcatg aaaatgtggg   1860

gaagggttcc cttttctcca ggtccagctc cccctcctca tatgggagag ctggaccagg   1920

aacgactgac caggcagcaa gaactcacag ccttatacca gatgcagcac ctgcagtacc   1980

agcagttttt aatacaacaa caatatgcac aggttttggc ccaacagcag aaagcagcac   2040

tgtcttccca gcagcagcag cagttggcac ttcttcttca acagtttcag accttgaaga   2100

tgagaatatc tgatcagaac atcattccct cagtaactag gtctgtgtcc gtgccagata   2160

ctggctctat ctgggagctt cagccaacag cttcacagcc tacagtttgg gaaggtggta   2220

gtgtatggga tcttcctctg gacaccacga caccaggccc tgccctggaa cagcttcagc   2280

agctagagaa ggccaaagct gcaaagctag agcaagagag aagagaggca gaaatgaggg   2340

caaaacggga agaggaagag cgaaagaggc aggaagaact ccgaagacaa caggaggaaa   2400

ttcttcggcg acagcaggaa gaagaaagga aaaggcgaga ggaagaagaa cttgcccgaa   2460

ggaaacagga agaggctctg cgtcgccagc gggagcaaga aattgcatta aggcgacagc   2520

gagaagagga agaaagacag cagcaagaag aagctcttag aagactggaa gagaggagaa   2580

gagaagagga agaaaggcgg aagcaggaag aattgttacg caaacaggaa gaggaggctg   2640

caaaatgggc ccgggaagaa gaagaagccc agcgtcgatt agaggagaac cggctgcgga   2700

tggaagagga ggcagccaga ctccggcatg aggaagaaga acggaagaga aaggagctgg   2760

aggtccagcg gcagaaggag ttaatgcgcc agaggcagca gcagcaagag gctctccgga   2820

ggttgcagca gcagcagcag caacaacagc tggcgcagat gaagcttcct tcttcttcaa   2880

cgtggggcca gcagtccaat acaacagcat gtcagtccca ggccacgctg tcgttggctg   2940

aaatccaaaa actagaggaa gaacgagaac ggcagcttcg agaagagcaa aggcgccagc   3000

agagggagtt gatgaaagct cttcagcagc agcagcaaca gcaacagcag aaactctcag   3060

gttgggggaa tgtcagcaaa ccttcaggta ccacgaaatc tcttctggag atccagcagg   3120

aagaggccag gcaaatgcaa aagcagcagc agcagcagca gcaacaccag caaccaaaca   3180

gagctcgtaa caatacgcat tccaacctgc acaccagcat tgggaattct gtttggggct   3240

ctataaatac tggtcctcct aaccagtggg catctgacct agtcagtagt atttggagta   3300

atgctgacac taaaaactcc aacatgggat tctgggatga tgcagtgaaa gaggtgggac   3360

ctaggaattc aacaaataaa aataaaaaca acgccagtct cagtaaatct gtaggtgtgt   3420

ctaaccggca gaataagaaa gtagaagaag aagaaaagtt gctgaagctc tttcagggag   3480

taaataaagc ccaagatgga tttacgcagt ggtgtgaaca gatgcttcat gcccttaata   3540

cggcaaataa cttggatgtt cccacatttg tttctttcct gaaagaagta gaatctcctt   3600

atgaggtcca tgattatatc agggcctatt taggagatac ttctgaggcc aaggagtttg   3660

ccaagcagtt ccttgagcgc cgtgccaaac agaaagccaa ccagcagcgt cagcagcagc   3720

agctgccaca gcagcagcag cagcagccgc cacagcagcc gccacagcag ccacaacagc   3780

aggactctgt gtgggggatg aaccacagta cactccattc agtatttcag accaatcaaa   3840

gcaacaacca acaatccaat tttgaggctg tgcagagtgg caagaagaag aaaaagcaga   3900

agatggtccg agcagatccc agtttattag gattttcagt caatgcatca tcggagcgac   3960

tcaacatggg tgaaatcgag acgttggatg actactgagc acctgccagt ggactggcca   4020

tccctctcct gtctgccgac tatggagtct ccacctttgg acacaacact tactcaccat   4080

ttactcttta tcactctgca acaaatcaca gaaccgatca tctcaggctt tttcttctgg   4140

ccctttgtgt ccaagattct ttaatccatt tttgttggtg aacatctcag actatagata   4200

agtggactgg accctgtgtc ttgggggtgg cagttgggat tactccccaa caaggctgat   4260

tttaggcagc atgtgttcac tgtgctgtga tttcatctac tgtctcccag aaagtgtgtt   4320

gggatcggcc attagcagct tgctttctct tgtcactttt tttcttctat tttgtttttt   4380

cttcttcttt ttccccccat cagggcaaat ggtctaactg gtgcaatcat gaagagagtt   4440

aatggttaac agacattggc caataacaaa acaccccatg gactgtgact cgagtatcca   4500

acaggcagtc agagctctcc cggtctgaaa gttgcattgc cactgctaac tttgggattg   4560

catcagagag gccctgagtg gggttgagat gaggttggtt tggtttgatg ttacacactc   4620

ctcacctgtt ctttctgagt gtcctttctc tgaaaggatt tatgtttttc ttcgttagat   4680

agtgacttct gagcaagctg atctcccctg gcatgctcca acctgattgg acaaaggaag   4740

ctctatggcc tgggagagag actattctta atttttcttt cttacaaaaa ctgatttttc   4800

ccataaatat ttttacttca gaggactagg accattttgt tttgggccct tctgctgaaa   4860

atttgtctcg tttaagaggc agctagaatc tttaccatat gtatgaattt gtataatttc   4920

atttttggat agggataaac ttttgcttct gataaaagcc tggaatttca tctggtcctc   4980

agagcattgc gtgtgtgtct tgctgtagcc cggaaaaggt tttgtgtaaa gattctggga   5040

tggcaagttg tttgcctttt ctgaaaagag aacatacaga acctgtccat ctttaagacc   5100

ttcatccatg gaatctacta tacaggagga tgcagtgggc tggaggggat gggcgaaaat   5160

gggagcagga agcctggcct ggcttctggt catggcctcc taaaacctta aacttcaagt   5220

agaaatgtac tcaagcccta tttataaaca aatacttttc ctgcctccac caaaccccta   5280

cagaacatca cctggaattg ccactcacac tgggttggag tcattgggca gctgtgcctg   5340

tgcgagaggt gctgtggtct gggcagcccc tggaaaagca cctttgctgc ctgtcattgt   5400

tgcctgaaga aggctggagt tgctctgaga gcagtttggg tttggagtat tatatttggc   5460

ttctattttt attattttgg atcaccattc tccctatccc ttcttgcctc cctcccttct   5520

aaacatgtgt aataactata cagagactgc tacaaaattg tatatagttt ttggatcaaa   5580

tagcatgagg ggagaggaaa ccattaaaag ttggggctcc tactctcctt tgctttgtaa   5640

attcaaaagt tgggggtggg taagagggat agttaaaatg tttacaaaac tttaggctcc   5700

ctcggaactt ttgccagtgt ggaggaaaat aaaaaagaac ttaaataaaa tctgattgta   5760

ttct                                                                5764


<210>  62
<211>  1299
<212>  PRT
<213>  Homosapiens

<400>  62

Met Ala Ala Glu Thr Gln Thr Leu Asn Phe Gly Pro Glu Trp Leu Arg 
1               5                   10                  15      


Ala Leu Ser Ser Gly Gly Ser Ile Thr Ser Pro Pro Leu Ser Pro Ala 
            20                  25                  30          


Leu Pro Lys Tyr Lys Leu Ala Asp Tyr Arg Tyr Gly Arg Glu Glu Met 
        35                  40                  45              


Leu Ala Leu Phe Leu Lys Asp Asn Lys Ile Pro Ser Asp Leu Leu Asp 
    50                  55                  60                  


Lys Glu Phe Leu Pro Ile Leu Gln Glu Glu Pro Leu Pro Pro Leu Ala 
65                  70                  75                  80  


Leu Val Pro Phe Thr Glu Glu Glu Gln Arg Asn Phe Ser Met Ser Val 
                85                  90                  95      


Asn Ser Ala Ala Val Leu Arg Leu Thr Gly Arg Gly Gly Gly Gly Thr 
            100                 105                 110         


Val Val Gly Ala Pro Arg Gly Arg Ser Ser Ser Arg Gly Arg Gly Arg 
        115                 120                 125             


Gly Arg Gly Glu Cys Gly Phe Tyr Gln Arg Ser Phe Asp Glu Val Glu 
    130                 135                 140                 


Gly Val Phe Gly Arg Gly Gly Gly Arg Glu Met His Arg Ser Gln Ser 
145                 150                 155                 160 


Trp Glu Glu Arg Gly Asp Arg Arg Phe Glu Lys Pro Gly Arg Lys Asp 
                165                 170                 175     


Val Gly Arg Pro Asn Phe Glu Glu Gly Gly Pro Thr Ser Val Gly Arg 
            180                 185                 190         


Lys His Glu Phe Ile Arg Ser Glu Ser Glu Asn Trp Arg Ile Phe Arg 
        195                 200                 205             


Glu Glu Gln Asn Gly Glu Asp Glu Asp Gly Gly Trp Arg Leu Ala Gly 
    210                 215                 220                 


Ser Arg Arg Asp Gly Glu Arg Trp Arg Pro His Ser Pro Asp Gly Pro 
225                 230                 235                 240 


Arg Ser Ala Gly Trp Arg Glu His Met Glu Arg Arg Arg Arg Phe Glu 
                245                 250                 255     


Phe Asp Phe Arg Asp Arg Asp Asp Glu Arg Gly Tyr Arg Arg Val Arg 
            260                 265                 270         


Ser Gly Ser Gly Ser Ile Asp Asp Asp Arg Asp Ser Leu Pro Glu Trp 
        275                 280                 285             


Cys Leu Glu Asp Ala Glu Glu Glu Met Gly Thr Phe Asp Ser Ser Gly 
    290                 295                 300                 


Ala Phe Leu Ser Leu Lys Lys Val Gln Lys Glu Pro Ile Pro Glu Glu 
305                 310                 315                 320 


Gln Glu Met Asp Phe Arg Pro Val Asp Glu Gly Glu Glu Cys Ser Asp 
                325                 330                 335     


Ser Glu Gly Ser His Asn Glu Glu Ala Lys Glu Pro Asp Lys Thr Asn 
            340                 345                 350         


Lys Lys Glu Gly Glu Lys Thr Asp Arg Val Gly Val Glu Ala Ser Glu 
        355                 360                 365             


Glu Thr Pro Gln Thr Ser Ser Ser Ser Ala Arg Pro Gly Thr Pro Ser 
    370                 375                 380                 


Asp His Gln Ser Gln Glu Ala Ser Gln Phe Glu Arg Lys Asp Glu Pro 
385                 390                 395                 400 


Lys Thr Glu Gln Thr Glu Lys Ala Glu Glu Glu Thr Arg Met Glu Asn 
                405                 410                 415     


Ser Leu Pro Ala Lys Val Pro Ser Arg Gly Asp Glu Met Val Ala Asp 
            420                 425                 430         


Val Gln Gln Pro Leu Ser Gln Ile Pro Ser Asp Thr Ala Ser Pro Leu 
        435                 440                 445             


Leu Ile Leu Pro Pro Pro Val Pro Asn Pro Ser Pro Thr Leu Arg Pro 
    450                 455                 460                 


Val Glu Thr Pro Val Val Gly Ala Pro Gly Met Gly Ser Val Ser Thr 
465                 470                 475                 480 


Glu Pro Asp Asp Glu Glu Gly Leu Lys His Leu Glu Gln Gln Ala Glu 
                485                 490                 495     


Lys Met Val Ala Tyr Leu Gln Asp Ser Ala Leu Asp Asp Glu Arg Leu 
            500                 505                 510         


Ala Ser Lys Leu Gln Glu His Arg Ala Lys Gly Val Ser Ile Pro Leu 
        515                 520                 525             


Met His Glu Ala Met Gln Lys Trp Tyr Tyr Lys Asp Pro Gln Gly Glu 
    530                 535                 540                 


Ile Gln Gly Pro Phe Asn Asn Gln Glu Met Ala Glu Trp Phe Gln Ala 
545                 550                 555                 560 


Gly Tyr Phe Thr Met Ser Leu Leu Val Lys Arg Ala Cys Asp Glu Ser 
                565                 570                 575     


Phe Gln Pro Leu Gly Asp Ile Met Lys Met Trp Gly Arg Val Pro Phe 
            580                 585                 590         


Ser Pro Gly Pro Ala Pro Pro Pro His Met Gly Glu Leu Asp Gln Glu 
        595                 600                 605             


Arg Leu Thr Arg Gln Gln Glu Leu Thr Ala Leu Tyr Gln Met Gln His 
    610                 615                 620                 


Leu Gln Tyr Gln Gln Phe Leu Ile Gln Gln Gln Tyr Ala Gln Val Leu 
625                 630                 635                 640 


Ala Gln Gln Gln Lys Ala Ala Leu Ser Ser Gln Gln Gln Gln Gln Leu 
                645                 650                 655     


Ala Leu Leu Leu Gln Gln Phe Gln Thr Leu Lys Met Arg Ile Ser Asp 
            660                 665                 670         


Gln Asn Ile Ile Pro Ser Val Thr Arg Ser Val Ser Val Pro Asp Thr 
        675                 680                 685             


Gly Ser Ile Trp Glu Leu Gln Pro Thr Ala Ser Gln Pro Thr Val Trp 
    690                 695                 700                 


Glu Gly Gly Ser Val Trp Asp Leu Pro Leu Asp Thr Thr Thr Pro Gly 
705                 710                 715                 720 


Pro Ala Leu Glu Gln Leu Gln Gln Leu Glu Lys Ala Lys Ala Ala Lys 
                725                 730                 735     


Leu Glu Gln Glu Arg Arg Glu Ala Glu Met Arg Ala Lys Arg Glu Glu 
            740                 745                 750         


Glu Glu Arg Lys Arg Gln Glu Glu Leu Arg Arg Gln Gln Glu Glu Ile 
        755                 760                 765             


Leu Arg Arg Gln Gln Glu Glu Glu Arg Lys Arg Arg Glu Glu Glu Glu 
    770                 775                 780                 


Leu Ala Arg Arg Lys Gln Glu Glu Ala Leu Arg Arg Gln Arg Glu Gln 
785                 790                 795                 800 


Glu Ile Ala Leu Arg Arg Gln Arg Glu Glu Glu Glu Arg Gln Gln Gln 
                805                 810                 815     


Glu Glu Ala Leu Arg Arg Leu Glu Glu Arg Arg Arg Glu Glu Glu Glu 
            820                 825                 830         


Arg Arg Lys Gln Glu Glu Leu Leu Arg Lys Gln Glu Glu Glu Ala Ala 
        835                 840                 845             


Lys Trp Ala Arg Glu Glu Glu Glu Ala Gln Arg Arg Leu Glu Glu Asn 
    850                 855                 860                 


Arg Leu Arg Met Glu Glu Glu Ala Ala Arg Leu Arg His Glu Glu Glu 
865                 870                 875                 880 


Glu Arg Lys Arg Lys Glu Leu Glu Val Gln Arg Gln Lys Glu Leu Met 
                885                 890                 895     


Arg Gln Arg Gln Gln Gln Gln Glu Ala Leu Arg Arg Leu Gln Gln Gln 
            900                 905                 910         


Gln Gln Gln Gln Gln Leu Ala Gln Met Lys Leu Pro Ser Ser Ser Thr 
        915                 920                 925             


Trp Gly Gln Gln Ser Asn Thr Thr Ala Cys Gln Ser Gln Ala Thr Leu 
    930                 935                 940                 


Ser Leu Ala Glu Ile Gln Lys Leu Glu Glu Glu Arg Glu Arg Gln Leu 
945                 950                 955                 960 


Arg Glu Glu Gln Arg Arg Gln Gln Arg Glu Leu Met Lys Ala Leu Gln 
                965                 970                 975     


Gln Gln Gln Gln Gln Gln Gln Gln Lys Leu Ser Gly Trp Gly Asn Val 
            980                 985                 990         


Ser Lys Pro Ser Gly Thr Thr Lys  Ser Leu Leu Glu Ile  Gln Gln Glu 
        995                 1000                 1005             


Glu Ala  Arg Gln Met Gln Lys  Gln Gln Gln Gln Gln  Gln Gln His 
    1010                 1015                 1020             


Gln Gln  Pro Asn Arg Ala Arg  Asn Asn Thr His Ser  Asn Leu His 
    1025                 1030                 1035             


Thr Ser  Ile Gly Asn Ser Val  Trp Gly Ser Ile Asn  Thr Gly Pro 
    1040                 1045                 1050             


Pro Asn  Gln Trp Ala Ser Asp  Leu Val Ser Ser Ile  Trp Ser Asn 
    1055                 1060                 1065             


Ala Asp  Thr Lys Asn Ser Asn  Met Gly Phe Trp Asp  Asp Ala Val 
    1070                 1075                 1080             


Lys Glu  Val Gly Pro Arg Asn  Ser Thr Asn Lys Asn  Lys Asn Asn 
    1085                 1090                 1095             


Ala Ser  Leu Ser Lys Ser Val  Gly Val Ser Asn Arg  Gln Asn Lys 
    1100                 1105                 1110             


Lys Val  Glu Glu Glu Glu Lys  Leu Leu Lys Leu Phe  Gln Gly Val 
    1115                 1120                 1125             


Asn Lys  Ala Gln Asp Gly Phe  Thr Gln Trp Cys Glu  Gln Met Leu 
    1130                 1135                 1140             


His Ala  Leu Asn Thr Ala Asn  Asn Leu Asp Val Pro  Thr Phe Val 
    1145                 1150                 1155             


Ser Phe  Leu Lys Glu Val Glu  Ser Pro Tyr Glu Val  His Asp Tyr 
    1160                 1165                 1170             


Ile Arg  Ala Tyr Leu Gly Asp  Thr Ser Glu Ala Lys  Glu Phe Ala 
    1175                 1180                 1185             


Lys Gln  Phe Leu Glu Arg Arg  Ala Lys Gln Lys Ala  Asn Gln Gln 
    1190                 1195                 1200             


Arg Gln  Gln Gln Gln Leu Pro  Gln Gln Gln Gln Gln  Gln Pro Pro 
    1205                 1210                 1215             


Gln Gln  Pro Pro Gln Gln Pro  Gln Gln Gln Asp Ser  Val Trp Gly 
    1220                 1225                 1230             


Met Asn  His Ser Thr Leu His  Ser Val Phe Gln Thr  Asn Gln Ser 
    1235                 1240                 1245             


Asn Asn  Gln Gln Ser Asn Phe  Glu Ala Val Gln Ser  Gly Lys Lys 
    1250                 1255                 1260             


Lys Lys  Lys Gln Lys Met Val  Arg Ala Asp Pro Ser  Leu Leu Gly 
    1265                 1270                 1275             


Phe Ser  Val Asn Ala Ser Ser  Glu Arg Leu Asn Met  Gly Glu Ile 
    1280                 1285                 1290             


Glu Thr  Leu Asp Asp Tyr 
    1295                 


<210>  63
<211>  7715
<212>  DNA
<213>  Homosapiens

<400>  63
gttgttgagg ctgaggactg actggggttc tgagactccc tgtcccggac cgcaggtttc     60

ttcacatata aaaatctatt gtaaaaatac ggaaaagaat ggcagcggaa acgcagacac    120

tgaactttgg gcctgaatgg ctccgagctc tgtccagtgg tgggagtatt acatcccctc    180

ctctttctcc agcattgccg aagtataaat tagcagatta tcgttacggc agagaagaaa    240

tgttagcact tttccttaaa gacaacaaga taccttcaga ccttctggat aaagaatttc    300

tgcctatcct ccaggaggaa ccccttccac cattggctct ggtacccttt acagaagaag    360

aacagagaaa cttttccatg tctgtaaata gtgctgctgt cctgcgattg acaggacgag    420

gaggaggagg aacagtggtg ggggctccta gaggtcgaag ttcttcaaga gggcgaggca    480

gaggcagagg tgaatgtggt ttctaccaaa gaagttttga tgaagtagag ggtgtttttg    540

gtcgaggagg tggcagagaa atgcatagat cgcagagctg ggaggaaagg ggtgacagac    600

gttttgaaaa accaggacga aaagatgtag ggagaccaaa ttttgaggaa ggtggaccaa    660

catcagtagg gagaaagcat gaatttatac gctcagaaag tgaaaattgg cgcatcttta    720

gagaggaaca aaatggagaa gatgaagatg gaggttggcg actagctgga tcaaggaggg    780

atggagagag gtggcgacct cacagtcctg atggccctcg ttctgcaggc tggcgggaac    840

acatggaacg acgtcggagg tttgagtttg attttcgaga tagagatgat gaacggggtt    900

accgaagggt tcgctctggc agtgggagca tagatgatga cagggatagc ttgcccgaat    960

ggtgcttaga ggatgctgaa gaagaaatgg gtacatttga ctcatctgga gcattccttt   1020

ctctaaaaaa agtacagaaa gagcctattc cagaagagca ggagatggac ttccggcctg   1080

tggacgaagg ggaggagtgc tctgactctg agggtagcca taatgaagag gccaaagaac   1140

ccgataagac aaataagaaa gaaggagaga aaacagatag agtaggagtt gaagctagtg   1200

aggaaactcc ccagacctca tcatcatctg ctagaccagg tactccttca gaccatcagt   1260

ctcaggaagc atcacagttt gagaggaaag atgaaccaaa aactgagcaa acggaaaaag   1320

ctgaagagga gactcggatg gaaaatagtc taccagccaa agtgcccagc agaggggatg   1380

aaatggttgc tgatgtccag cagcccctgt cgcagattcc ttcagataca gcctctcctc   1440

ttctcatact tccacctcct gttcccaatc ctagtcctac tctccggcca gttgaaacac   1500

cagttgtagg tgctcctggt atgggcagtg tttccacaga acctgatgat gaagaaggtc   1560

tcaaacattt ggagcagcaa gctgagaaaa tggtggctta tctccaagac agtgcactag   1620

atgatgaaag attggcatca aaactgcaag agcacagagc taaaggagtg tcgattccat   1680

tgatgcatga agcaatgcag aagtggtatt acaaagatcc tcagggagaa attcaaggtc   1740

ccttcaataa tcaggagatg gcagaatggt ttcaggcggg ctattttact atgtctttat   1800

tggtgaagag agcgtgtgat gaaagcttcc aacctcttgg cgatatcatg aaaatgtggg   1860

gaagggttcc cttttctcca ggtccagctc cccctcctca tatgggagag ctggaccagg   1920

aacgactgac caggcagcaa gaactcacag ccttatacca gatgcagcac ctgcagtacc   1980

agcagttttt aatacaacaa caatatgcac aggttttggc ccaacagcag aaagcagcac   2040

tgtcttccca gcagcagcag cagttggcac ttcttcttca acagtttcag accttgaaga   2100

tgagaatatc tgatcagaac atcattccct cagtaactag gtctgtgtcc gtgccagata   2160

ctggctctat ctgggagctt cagccaacag cttcacagcc tacagtttgg gaaggtggta   2220

gtgtatggga tcttcctctg gacaccacga caccaggccc tgccctggaa cagcttcagc   2280

agctagagaa ggccaaagct gcaaagctag agcaagagag aagagaggca gaaatgaggg   2340

caaaacggga agaggaagag cgaaagaggc aggaagaact ccgaagacaa caggaggaaa   2400

ttcttcggcg acagcaggaa gaagaaagga aaaggcgaga ggaagaagaa cttgcccgaa   2460

ggaaacagga agaggctctg cgtcgccagc gggagcaaga aattgcatta aggcgacagc   2520

gagaagagga agaaagacag cagcaagaag aagctcttag aagactggaa gagaggagaa   2580

gagaagagga agaaaggcgg aagcaggaag aattgttacg caaacaggaa gaggaggctg   2640

caaaatgggc ccgggaagaa gaagaagccc agcgtcgatt agaggagaac cggctgcgga   2700

tggaagagga ggcagccaga ctccggcatg aggaagaaga acggaagaga aaggagctgg   2760

aggtccagcg gcagaaggag ttaatgcgcc agaggcagca gcagcaagag gctctccgga   2820

ggttgcagca gcagcagcag caacaacagc tggcgcagat gaagcttcct tcttcttcaa   2880

cgtggggcca gcagtccaat acaacagcat gtcagtccca ggccacgctg tcgttggctg   2940

aaatccaaaa actagaggaa gaacgagaac ggcagcttcg agaagagcaa aggcgccagc   3000

agagggagtt gatgaaagct cttcagcagc agcagcaaca gcaacagcag aaactctcag   3060

gttgggggaa tgtcagcaaa ccttcaggta ccacgaaatc tcttctggag atccagcagg   3120

aagaggccag gcaaatgcaa aagcagcagc agcagcagca gcaacaccag caaccaaaca   3180

gagctcgtaa caatacgcat tccaacctgc acaccagcat tgggaattct gtttggggct   3240

ctataaatac tggtcctcct aaccagtggg catctgacct agtcagtagt atttggagta   3300

atgctgacac taaaaactcc aacatgggat tctgggatga tgcagtgaaa gaggtgggac   3360

ctaggaattc aacaaataaa aataaaaaca acgccagtct cagtaaatct gtaggtgtgt   3420

ctaaccggca gaataagaaa gtagaagaag aagaaaagtt gctgaagctc tttcagggag   3480

taaataaagc ccaagatgga tttacgcagt ggtgtgaaca gatgcttcat gcccttaata   3540

cggcaaataa cttggatgtt cccacatttg tttctttcct gaaagaagta gaatctcctt   3600

atgaggtcca tgattatatc agggcctatt taggagatac ttctgaggcc aaggagtttg   3660

ccaagcagtt ccttgagcgc cgtgccaaac agaaagccaa ccagcagcgt cagcagcagc   3720

agctgccaca gcagcagcag cagcagccgc cacagcagcc gccacagcag ccacaacagc   3780

aggactctgt gtgggggatg aaccacagta cactccattc agtatttcag accaatcaaa   3840

gcaacaacca acaatccaat tttgaggctg tgcagagtgg caagaagaag aaaaagcaga   3900

agatggtccg agcagatccc agtttattag gattttcagt caatgcatca tcggagcgac   3960

tcaacatggg tgaaatcgag acgttggatg actactgagc acctgccagt ggactggcca   4020

tccctctcct gtctgccgac tatggagtct ccacctttgg acacaacact tactcaccat   4080

ttactcttta tcactctgca acaaatcaca gaaccgatca tctcaggctt tttcttctgg   4140

ccctttgtgt ccaagattct ttaatccatt tttgttggtg aacatctcag actatagata   4200

agtggactgg accctgtgtc ttgggggtgg cagttgggat tactccccaa caaggctgat   4260

tttaggcagc atgtgttcac tgtgctgtga tttcatctac tgtctcccag aaagtgtgtt   4320

gggatcggcc attagcagct tgctttctct tgtcactttt tttcttctat tttgtttttt   4380

cttcttcttt ttccccccat cagggcaaat ggtctaactg gtgcaatcat gaagagagtt   4440

aatggttaac agacattggc caataacaaa acaccccatg gactgtgact cgagtatcca   4500

acaggcagtc agagctctcc cggtctgaaa gttgcattgc cactgctaac tttgggattg   4560

catcagagag gccctgagtg gggttgagat gaggttggtt tggtttgatg ttacacactc   4620

ctcacctgtt ctttctgagt gtcctttctc tgaaaggatt tatgtttttc ttcgttagat   4680

agtgacttct gagcaagctg atctcccctg gcatgctcca acctgattgg acaaaggaag   4740

ctctatggcc tgggagagag actattctta atttttcttt cttacaaaaa ctgatttttc   4800

ccataaatat ttttacttca gaggactagg accattttgt tttgggccct tctgctgaaa   4860

atttgtctcg tttaagaggc agctagaatc tttaccatat gtatgaattt gtataatttc   4920

atttttggat agggataaac ttttgcttct gataaaagcc tggaatttca tctggtcctc   4980

agagcattgc gtgtgtgtct tgctgtagcc cggaaaaggt tttgtgtaaa gattctggga   5040

tggcaagttg tttgcctttt ctgaaaagag aacatacaga acctgtccat ctttaagacc   5100

ttcatccatg gaatctacta tacaggagga tgcagtgggc tggaggggat gggcgaaaat   5160

gggagcagga agcctggcct ggcttctggt catggcctcc taaaacctta aacttcaagt   5220

agaaatgtac tcaagcccta tttataaaca aatacttttc ctgcctccac caaaccccta   5280

cagaacatca cctggaattg ccactcacac tgggttggag tcattgggca gctgtgcctg   5340

tgcgagaggt gctgtggtct gggcagcccc tggaaaagca cctttgctgc ctgtcattgt   5400

tgcctgaaga aggctggagt tgctctgaga gcagtttggg tttggagtat tatatttggc   5460

ttctattttt attattttgg atcaccattc tccctatccc ttcttgcctc cctcccttct   5520

aaacatgtgt aataactata cagagactgc tacaaaattg tatatagttt ttggatcaaa   5580

tagcatgagg ggagaggaaa ccattaaaag ttggggctcc tactctcctt tgctttgtaa   5640

attcaaaagt tgggggtggg taagagggat agttaaaatg tttacaaaac tttaggctcc   5700

ctcggaactt ttgccagtgt ggaggaaaat aaaaaagaac ttaaataaaa tctgattgta   5760

ttctatctga gtgcacctct tgtactcacc tttatggagg ctgagttctg cactaaactg   5820

ttcctcttgg taccatggaa aagctccaag cacccaagac atggaggcag ccatggcttc   5880

tttctctgcc agaccacgta gcactggctg gttctgtatt tgagaatgta gaggtcaagg   5940

cagatgtcgg taagtttgac caaatatctt ttctcttttt gactctccct ttctgctaac   6000

atgtggatca gctcctgccc tcataccgca gacacaccca ctctgaacac acccctccag   6060

agcttgccca caccttccca actagactct gtgtgtgtat tcaggaaaaa tgaaaataaa   6120

tttttaaaaa ttgggagtgg aatgggcaga ttagggggaa caaagtcatt ttggtcatgg   6180

aacatccatt tgcttaacca aggagacttg cttctatctg aggaatttcc cacttagtag   6240

aaagaaacac tcttccctgg gaatgtttgt ttctgtctct ctcaatgcta ctctctttca   6300

tattctcatt tgctcaccct ttcacttaga gccaccgttt tctcatccca ttctatgaac   6360

ttatttccaa attctcctaa ctattcctga gttttgaagt atttgttttg taccctctct   6420

gcttccggtt ttttgtttgg ttggcttttt tggagatagg gtcttgtgat gttgcccaca   6480

ctggtctcga gcccctgggc tcaagtgatc ctcccgcctc agcctcctaa atatctagga   6540

ctacaggtgt gtgccaccat gcccagctcc agttttgttg gttgatttgt ttaaattcag   6600

agatttaaaa acatcccaga caagacagtt tgattatgga gactgtcccc aagcagattg   6660

gtgtgctggt ggctgctgtg cataacagat tccctccaga ttggcttaca acagctactt   6720

cattctgtgg gtcaggaatt tggatagggc tcagctgggt ggtggttctc ctggggtatt   6780

ctttggttgt ggtcagatgt cttccagggc atcattccta tgaaggctta atgaattagg   6840

caagctgtcc aagatggctc actcgtgtaa tgacagttga cgttggctgt aggctgggaa   6900

ctcagctggg ttgatgactg gaggagctta tgtgtgtcgt ctccggaatg gcagcttcag   6960

aggagttgaa cttaagtggt gattggcttc ccccagagaa ccaggcagaa gctgtgttac   7020

ctttttgagc tcttagctca ggagtcacat agagtcactt ctgtgacact gtgttgcatc   7080

aaagtagtca caaacccact cagattcaag agaagggagc atggccctct ccctgcaacc   7140

ccctcccccc ccgccttgat gaaaggagtg acaaggtcac attggagaag agcttgtggg   7200

gtgggagata ttatagccat ttttgggaaa tatctgcata aaatgagttt atgcatacat   7260

gaaggacttt attttcattg gctttaagtt gagggttttt gtttttgttt ttgtattgga   7320

gatgggttct tactatgttg cccaggctgg tctcaaaccc ctgggctcaa gtgatcctgt   7380

tgcctcagcc tcccaagtag ctgggactac agctatgtgc cagtgcaccc agcttgtttt   7440

ttttaaattt taggatagat aatggtactt ctggctttat ttaaataatt tttttaggga   7500

aaccattgta tttatacatg catatatttt tatatataca aatatgtata taaaagtata   7560

tgttttacat tttcaatata tatataatat atacatatat gttatatacg tatatatatt   7620

gcaccctact ttaaaattga ctgataacaa aattggtaat tttgtataaa atgcccaact   7680

gtgcattatt aataaaagta tgtgaatgac tctaa                              7715


<210>  64
<211>  1299
<212>  PRT
<213>  Homosapiens

<400>  64

Met Ala Ala Glu Thr Gln Thr Leu Asn Phe Gly Pro Glu Trp Leu Arg 
1               5                   10                  15      


Ala Leu Ser Ser Gly Gly Ser Ile Thr Ser Pro Pro Leu Ser Pro Ala 
            20                  25                  30          


Leu Pro Lys Tyr Lys Leu Ala Asp Tyr Arg Tyr Gly Arg Glu Glu Met 
        35                  40                  45              


Leu Ala Leu Phe Leu Lys Asp Asn Lys Ile Pro Ser Asp Leu Leu Asp 
    50                  55                  60                  


Lys Glu Phe Leu Pro Ile Leu Gln Glu Glu Pro Leu Pro Pro Leu Ala 
65                  70                  75                  80  


Leu Val Pro Phe Thr Glu Glu Glu Gln Arg Asn Phe Ser Met Ser Val 
                85                  90                  95      


Asn Ser Ala Ala Val Leu Arg Leu Thr Gly Arg Gly Gly Gly Gly Thr 
            100                 105                 110         


Val Val Gly Ala Pro Arg Gly Arg Ser Ser Ser Arg Gly Arg Gly Arg 
        115                 120                 125             


Gly Arg Gly Glu Cys Gly Phe Tyr Gln Arg Ser Phe Asp Glu Val Glu 
    130                 135                 140                 


Gly Val Phe Gly Arg Gly Gly Gly Arg Glu Met His Arg Ser Gln Ser 
145                 150                 155                 160 


Trp Glu Glu Arg Gly Asp Arg Arg Phe Glu Lys Pro Gly Arg Lys Asp 
                165                 170                 175     


Val Gly Arg Pro Asn Phe Glu Glu Gly Gly Pro Thr Ser Val Gly Arg 
            180                 185                 190         


Lys His Glu Phe Ile Arg Ser Glu Ser Glu Asn Trp Arg Ile Phe Arg 
        195                 200                 205             


Glu Glu Gln Asn Gly Glu Asp Glu Asp Gly Gly Trp Arg Leu Ala Gly 
    210                 215                 220                 


Ser Arg Arg Asp Gly Glu Arg Trp Arg Pro His Ser Pro Asp Gly Pro 
225                 230                 235                 240 


Arg Ser Ala Gly Trp Arg Glu His Met Glu Arg Arg Arg Arg Phe Glu 
                245                 250                 255     


Phe Asp Phe Arg Asp Arg Asp Asp Glu Arg Gly Tyr Arg Arg Val Arg 
            260                 265                 270         


Ser Gly Ser Gly Ser Ile Asp Asp Asp Arg Asp Ser Leu Pro Glu Trp 
        275                 280                 285             


Cys Leu Glu Asp Ala Glu Glu Glu Met Gly Thr Phe Asp Ser Ser Gly 
    290                 295                 300                 


Ala Phe Leu Ser Leu Lys Lys Val Gln Lys Glu Pro Ile Pro Glu Glu 
305                 310                 315                 320 


Gln Glu Met Asp Phe Arg Pro Val Asp Glu Gly Glu Glu Cys Ser Asp 
                325                 330                 335     


Ser Glu Gly Ser His Asn Glu Glu Ala Lys Glu Pro Asp Lys Thr Asn 
            340                 345                 350         


Lys Lys Glu Gly Glu Lys Thr Asp Arg Val Gly Val Glu Ala Ser Glu 
        355                 360                 365             


Glu Thr Pro Gln Thr Ser Ser Ser Ser Ala Arg Pro Gly Thr Pro Ser 
    370                 375                 380                 


Asp His Gln Ser Gln Glu Ala Ser Gln Phe Glu Arg Lys Asp Glu Pro 
385                 390                 395                 400 


Lys Thr Glu Gln Thr Glu Lys Ala Glu Glu Glu Thr Arg Met Glu Asn 
                405                 410                 415     


Ser Leu Pro Ala Lys Val Pro Ser Arg Gly Asp Glu Met Val Ala Asp 
            420                 425                 430         


Val Gln Gln Pro Leu Ser Gln Ile Pro Ser Asp Thr Ala Ser Pro Leu 
        435                 440                 445             


Leu Ile Leu Pro Pro Pro Val Pro Asn Pro Ser Pro Thr Leu Arg Pro 
    450                 455                 460                 


Val Glu Thr Pro Val Val Gly Ala Pro Gly Met Gly Ser Val Ser Thr 
465                 470                 475                 480 


Glu Pro Asp Asp Glu Glu Gly Leu Lys His Leu Glu Gln Gln Ala Glu 
                485                 490                 495     


Lys Met Val Ala Tyr Leu Gln Asp Ser Ala Leu Asp Asp Glu Arg Leu 
            500                 505                 510         


Ala Ser Lys Leu Gln Glu His Arg Ala Lys Gly Val Ser Ile Pro Leu 
        515                 520                 525             


Met His Glu Ala Met Gln Lys Trp Tyr Tyr Lys Asp Pro Gln Gly Glu 
    530                 535                 540                 


Ile Gln Gly Pro Phe Asn Asn Gln Glu Met Ala Glu Trp Phe Gln Ala 
545                 550                 555                 560 


Gly Tyr Phe Thr Met Ser Leu Leu Val Lys Arg Ala Cys Asp Glu Ser 
                565                 570                 575     


Phe Gln Pro Leu Gly Asp Ile Met Lys Met Trp Gly Arg Val Pro Phe 
            580                 585                 590         


Ser Pro Gly Pro Ala Pro Pro Pro His Met Gly Glu Leu Asp Gln Glu 
        595                 600                 605             


Arg Leu Thr Arg Gln Gln Glu Leu Thr Ala Leu Tyr Gln Met Gln His 
    610                 615                 620                 


Leu Gln Tyr Gln Gln Phe Leu Ile Gln Gln Gln Tyr Ala Gln Val Leu 
625                 630                 635                 640 


Ala Gln Gln Gln Lys Ala Ala Leu Ser Ser Gln Gln Gln Gln Gln Leu 
                645                 650                 655     


Ala Leu Leu Leu Gln Gln Phe Gln Thr Leu Lys Met Arg Ile Ser Asp 
            660                 665                 670         


Gln Asn Ile Ile Pro Ser Val Thr Arg Ser Val Ser Val Pro Asp Thr 
        675                 680                 685             


Gly Ser Ile Trp Glu Leu Gln Pro Thr Ala Ser Gln Pro Thr Val Trp 
    690                 695                 700                 


Glu Gly Gly Ser Val Trp Asp Leu Pro Leu Asp Thr Thr Thr Pro Gly 
705                 710                 715                 720 


Pro Ala Leu Glu Gln Leu Gln Gln Leu Glu Lys Ala Lys Ala Ala Lys 
                725                 730                 735     


Leu Glu Gln Glu Arg Arg Glu Ala Glu Met Arg Ala Lys Arg Glu Glu 
            740                 745                 750         


Glu Glu Arg Lys Arg Gln Glu Glu Leu Arg Arg Gln Gln Glu Glu Ile 
        755                 760                 765             


Leu Arg Arg Gln Gln Glu Glu Glu Arg Lys Arg Arg Glu Glu Glu Glu 
    770                 775                 780                 


Leu Ala Arg Arg Lys Gln Glu Glu Ala Leu Arg Arg Gln Arg Glu Gln 
785                 790                 795                 800 


Glu Ile Ala Leu Arg Arg Gln Arg Glu Glu Glu Glu Arg Gln Gln Gln 
                805                 810                 815     


Glu Glu Ala Leu Arg Arg Leu Glu Glu Arg Arg Arg Glu Glu Glu Glu 
            820                 825                 830         


Arg Arg Lys Gln Glu Glu Leu Leu Arg Lys Gln Glu Glu Glu Ala Ala 
        835                 840                 845             


Lys Trp Ala Arg Glu Glu Glu Glu Ala Gln Arg Arg Leu Glu Glu Asn 
    850                 855                 860                 


Arg Leu Arg Met Glu Glu Glu Ala Ala Arg Leu Arg His Glu Glu Glu 
865                 870                 875                 880 


Glu Arg Lys Arg Lys Glu Leu Glu Val Gln Arg Gln Lys Glu Leu Met 
                885                 890                 895     


Arg Gln Arg Gln Gln Gln Gln Glu Ala Leu Arg Arg Leu Gln Gln Gln 
            900                 905                 910         


Gln Gln Gln Gln Gln Leu Ala Gln Met Lys Leu Pro Ser Ser Ser Thr 
        915                 920                 925             


Trp Gly Gln Gln Ser Asn Thr Thr Ala Cys Gln Ser Gln Ala Thr Leu 
    930                 935                 940                 


Ser Leu Ala Glu Ile Gln Lys Leu Glu Glu Glu Arg Glu Arg Gln Leu 
945                 950                 955                 960 


Arg Glu Glu Gln Arg Arg Gln Gln Arg Glu Leu Met Lys Ala Leu Gln 
                965                 970                 975     


Gln Gln Gln Gln Gln Gln Gln Gln Lys Leu Ser Gly Trp Gly Asn Val 
            980                 985                 990         


Ser Lys Pro Ser Gly Thr Thr Lys  Ser Leu Leu Glu Ile  Gln Gln Glu 
        995                 1000                 1005             


Glu Ala  Arg Gln Met Gln Lys  Gln Gln Gln Gln Gln  Gln Gln His 
    1010                 1015                 1020             


Gln Gln  Pro Asn Arg Ala Arg  Asn Asn Thr His Ser  Asn Leu His 
    1025                 1030                 1035             


Thr Ser  Ile Gly Asn Ser Val  Trp Gly Ser Ile Asn  Thr Gly Pro 
    1040                 1045                 1050             


Pro Asn  Gln Trp Ala Ser Asp  Leu Val Ser Ser Ile  Trp Ser Asn 
    1055                 1060                 1065             


Ala Asp  Thr Lys Asn Ser Asn  Met Gly Phe Trp Asp  Asp Ala Val 
    1070                 1075                 1080             


Lys Glu  Val Gly Pro Arg Asn  Ser Thr Asn Lys Asn  Lys Asn Asn 
    1085                 1090                 1095             


Ala Ser  Leu Ser Lys Ser Val  Gly Val Ser Asn Arg  Gln Asn Lys 
    1100                 1105                 1110             


Lys Val  Glu Glu Glu Glu Lys  Leu Leu Lys Leu Phe  Gln Gly Val 
    1115                 1120                 1125             


Asn Lys  Ala Gln Asp Gly Phe  Thr Gln Trp Cys Glu  Gln Met Leu 
    1130                 1135                 1140             


His Ala  Leu Asn Thr Ala Asn  Asn Leu Asp Val Pro  Thr Phe Val 
    1145                 1150                 1155             


Ser Phe  Leu Lys Glu Val Glu  Ser Pro Tyr Glu Val  His Asp Tyr 
    1160                 1165                 1170             


Ile Arg  Ala Tyr Leu Gly Asp  Thr Ser Glu Ala Lys  Glu Phe Ala 
    1175                 1180                 1185             


Lys Gln  Phe Leu Glu Arg Arg  Ala Lys Gln Lys Ala  Asn Gln Gln 
    1190                 1195                 1200             


Arg Gln  Gln Gln Gln Leu Pro  Gln Gln Gln Gln Gln  Gln Pro Pro 
    1205                 1210                 1215             


Gln Gln  Pro Pro Gln Gln Pro  Gln Gln Gln Asp Ser  Val Trp Gly 
    1220                 1225                 1230             


Met Asn  His Ser Thr Leu His  Ser Val Phe Gln Thr  Asn Gln Ser 
    1235                 1240                 1245             


Asn Asn  Gln Gln Ser Asn Phe  Glu Ala Val Gln Ser  Gly Lys Lys 
    1250                 1255                 1260             


Lys Lys  Lys Gln Lys Met Val  Arg Ala Asp Pro Ser  Leu Leu Gly 
    1265                 1270                 1275             


Phe Ser  Val Asn Ala Ser Ser  Glu Arg Leu Asn Met  Gly Glu Ile 
    1280                 1285                 1290             


Glu Thr  Leu Asp Asp Tyr 
    1295                 


<210>  65
<211>  3060
<212>  DNA
<213>  Homosapiens

<400>  65
agtccaagaa gagaacctac aaactagact tgtagattaa aattatctga tcaaaaaggc     60

agactctgta aatttcctta agacctacct tggcataaag gctgacccag caaaagaact    120

gagaaataca gcctgagatg gacagcagta attgcaaagt tattgctcct ctcctaagtc    180

aaagataccg gaggatggtc accaaggatg gccacagcac acttcaaatg gatggcgctc    240

aaagaggtct tgcatatctt cgagatgctt ggggaatcct aatggacatg cgctggcgtt    300

ggatgatgtt ggtcttttct gcttcttttg ttgtccactg gcttgtcttt gcagtgctct    360

ggtatgttct ggctgagatg aatggtgatc tggaactaga tcatgatgcc ccacctgaaa    420

accacactat ctgtgtcaag tatatcacca gtttcacagc tgcattctcc ttctccctgg    480

agacacaact cacaattggt tatggtacca tgttccccag tggtgactgt ccaagtgcaa    540

tcgccttact tgccatacaa atgctcctag gcctcatgct agaggctttt atcacaggtg    600

cttttgtggc gaagattgcc cggccaaaaa atcgagcttt ttcaattcgc tttactgaca    660

cagcagtagt agctcacatg gatggcaaac ctaatcttat cttccaagtg gccaacaccc    720

gacctagccc tctaaccagt gtccgggtct cagctgtact ctatcaggaa agagaaaatg    780

gcaaactcta ccagaccagt gtggatttcc accttgatgg catcagttct gacgaatgtc    840

cattcttcat ctttccacta acgtactatc actccattac accatcaagt cctctggcta    900

ctctgctcca gcatgaaaat ccttctcact ttgaattagt tgtattcctt tcagcaatgc    960

aggagggcac tggagaaata tgccaaagga ggacatccta cctaccgtct gaaatcatgt   1020

tacatcactg ttttgcatct ctgttgaccc gaggttccaa aggtgaatat caaatcaaga   1080

tggagaattt tgacaagact gtccctgaat ttccaactcc tctggtttct aaaagcccaa   1140

acaggactga cctggatatc cacatcaatg gacaaagcat tgacaatttt cagatctctg   1200

aaacaggact gacagaataa gacttatcca ttttttaatg tattaaatac acccagccag   1260

ttatgcagct actttttctt tactgtatct catgttttct tttttcaatg ctaattatag   1320

ctctctacat cacggtaatc atgcctatgc ctacataaga atggctgagc taacaataca   1380

cattctggaa acataacact ctacattaca aagtttgtta cctgctgaaa tcaatgtaac   1440

tcaacttgac agacacttat acagaaatgt tgctggtgaa tttataagaa tgtggtatga   1500

tactagtaat gaaggcaaaa tggacagtga agtttaacac aactgaactc taagaaaatc   1560

aaccattaat ctctcatttt catctgcaaa ttgaagcaac agtttagttt caaacctagc   1620

tccctgggtg gaatgacgac ttcactatac ttagtgaata tcctttaaga gctgggattt   1680

ttttcaagac aacaaagatc attcatttgg ttctttatac tatgaaactt gagtaagtat   1740

tacctcctta atttttaaca actaagaaca aaaattaacg agaaaaacaa caaagtacag   1800

atttatacat aaacctaaaa gcatttgaac atgacacccg aacacataca tatatgttca   1860

cttatttgtg gcagaaggtg atcagataag ctccagccca aatggaacct gtggggtggt   1920

attttgcatt gcaaggagac gcaaaatttt attttaaaac tgtcctccat aataatcaaa   1980

cggtgattca tctaaatgac ttctagcaac ctaagtaaaa acattcccct cctatgtatg   2040

attcatttga tcatataaaa catcatgatg gctctaattc ataaatacaa aaatatattt   2100

aagtctttat agatataaag ctttacttag atataacttg agtgagtagg gaaaaaaatc   2160

tacagtagat aaagcaaaag ataattaggc aacaaagcat tttcaaactc aaattcctgt   2220

ttccaacttc aaatagtttt ttctataaac acaaaatcag tgtttattca ccagtaggag   2280

gttggactag atgaactcta ttatttcttt ctaaatctaa tagtctataa aaattatgtt   2340

tcctctgttt tttattttat ctatgctaaa atgagccctt tcccttatgt ccagtttaag   2400

atgatcattt gcatgatttt catttcaata aaaaaaagag aaactgtcct taaaacaaaa   2460

caaaaaccaa aaaagtcacc ctatcaggtt tcaaacagat ttgtggctgt tcttttctga   2520

aatttccctt attcaggttt ctgtgggaaa aatgaaagat taaccttccc cactggtgat   2580

gacctaggca ggaatcatct cttgaaataa atactagctg agtaaaggca agcaggtgtg   2640

aagagcaggg ctcagcagca agtcacattt ttctactatt tgaccaaaag gaaaagaaaa   2700

taaagaagaa ctctggagtg gtctaagact gataatagca gaagaatatc aagaacacag   2760

aaacttaatt attgtgaact tttgctgttt gaaaatctta gacattcatt cttaagtaga   2820

aatcagacca acagattttc ccaacccaag actattgtaa cacataaaga cagcaagaat   2880

tcttatttct ataataaatt aacaagattc acctaacctt tgaaaataaa gtagtattga   2940

agacttacat ggtatgtttt ttcctaaagg cactacatca cttacacagt tcaccctctc   3000

gcttgttaag tgaagctgcc caaggtgaca taagtgaatg agtaaaacct gagatctaag   3060


<210>  66
<211>  360
<212>  PRT
<213>  Homosapiens

<400>  66

Met Asp Ser Ser Asn Cys Lys Val Ile Ala Pro Leu Leu Ser Gln Arg 
1               5                   10                  15      


Tyr Arg Arg Met Val Thr Lys Asp Gly His Ser Thr Leu Gln Met Asp 
            20                  25                  30          


Gly Ala Gln Arg Gly Leu Ala Tyr Leu Arg Asp Ala Trp Gly Ile Leu 
        35                  40                  45              


Met Asp Met Arg Trp Arg Trp Met Met Leu Val Phe Ser Ala Ser Phe 
    50                  55                  60                  


Val Val His Trp Leu Val Phe Ala Val Leu Trp Tyr Val Leu Ala Glu 
65                  70                  75                  80  


Met Asn Gly Asp Leu Glu Leu Asp His Asp Ala Pro Pro Glu Asn His 
                85                  90                  95      


Thr Ile Cys Val Lys Tyr Ile Thr Ser Phe Thr Ala Ala Phe Ser Phe 
            100                 105                 110         


Ser Leu Glu Thr Gln Leu Thr Ile Gly Tyr Gly Thr Met Phe Pro Ser 
        115                 120                 125             


Gly Asp Cys Pro Ser Ala Ile Ala Leu Leu Ala Ile Gln Met Leu Leu 
    130                 135                 140                 


Gly Leu Met Leu Glu Ala Phe Ile Thr Gly Ala Phe Val Ala Lys Ile 
145                 150                 155                 160 


Ala Arg Pro Lys Asn Arg Ala Phe Ser Ile Arg Phe Thr Asp Thr Ala 
                165                 170                 175     


Val Val Ala His Met Asp Gly Lys Pro Asn Leu Ile Phe Gln Val Ala 
            180                 185                 190         


Asn Thr Arg Pro Ser Pro Leu Thr Ser Val Arg Val Ser Ala Val Leu 
        195                 200                 205             


Tyr Gln Glu Arg Glu Asn Gly Lys Leu Tyr Gln Thr Ser Val Asp Phe 
    210                 215                 220                 


His Leu Asp Gly Ile Ser Ser Asp Glu Cys Pro Phe Phe Ile Phe Pro 
225                 230                 235                 240 


Leu Thr Tyr Tyr His Ser Ile Thr Pro Ser Ser Pro Leu Ala Thr Leu 
                245                 250                 255     


Leu Gln His Glu Asn Pro Ser His Phe Glu Leu Val Val Phe Leu Ser 
            260                 265                 270         


Ala Met Gln Glu Gly Thr Gly Glu Ile Cys Gln Arg Arg Thr Ser Tyr 
        275                 280                 285             


Leu Pro Ser Glu Ile Met Leu His His Cys Phe Ala Ser Leu Leu Thr 
    290                 295                 300                 


Arg Gly Ser Lys Gly Glu Tyr Gln Ile Lys Met Glu Asn Phe Asp Lys 
305                 310                 315                 320 


Thr Val Pro Glu Phe Pro Thr Pro Leu Val Ser Lys Ser Pro Asn Arg 
                325                 330                 335     


Thr Asp Leu Asp Ile His Ile Asn Gly Gln Ser Ile Asp Asn Phe Gln 
            340                 345                 350         


Ile Ser Glu Thr Gly Leu Thr Glu 
        355                 360 


<210>  67
<211>  2824
<212>  DNA
<213>  Homosapiens

<400>  67
agtccaagaa gagaacctac aaactagact tgtagattaa aattatctga tcaaaaaggc     60

agactctgta aatttcctta agacctacct tggcataaag gctgacccag caaaagaact    120

gagaaataca gcctgagatg gacagcagta attgcaaagt tattgctcct ctcctaagtc    180

aaagataccg gaggatggtc accaaggatg gccacagcac acttcaaatg gatggcgctc    240

aaagaggtct tgcatatctt cgagatgctt ggggaatcct aatggacatg cgctggcgtt    300

ggatgatgtt ggtcttttct gcttcttttg ttgtccactg gcttgtcttt gcagtgctct    360

ggtgcttttg tggcgaagat tgcccggcca aaaaatcgag ctttttcaat tcgctttact    420

gacacagcag tagtagctca catggatggc aaacctaatc ttatcttcca agtggccaac    480

acccgaccta gccctctaac cagtgtccgg gtctcagctg tactctatca ggaaagagaa    540

aatggcaaac tctaccagac cagtgtggat ttccaccttg atggcatcag ttctgacgaa    600

tgtccattct tcatctttcc actaacgtac tatcactcca ttacaccatc aagtcctctg    660

gctactctgc tccagcatga aaatccttct cactttgaat tagttgtatt cctttcagca    720

atgcaggagg gcactggaga aatatgccaa aggaggacat cctacctacc gtctgaaatc    780

atgttacatc actgttttgc atctctgttg acccgaggtt ccaaaggtga atatcaaatc    840

aagatggaga attttgacaa gactgtccct gaatttccaa ctcctctggt ttctaaaagc    900

ccaaacagga ctgacctgga tatccacatc aatggacaaa gcattgacaa ttttcagatc    960

tctgaaacag gactgacaga ataagactta tccatttttt aatgtattaa atacacccag   1020

ccagttatgc agctactttt tctttactgt atctcatgtt ttcttttttc aatgctaatt   1080

atagctctct acatcacggt aatcatgcct atgcctacat aagaatggct gagctaacaa   1140

tacacattct ggaaacataa cactctacat tacaaagttt gttacctgct gaaatcaatg   1200

taactcaact tgacagacac ttatacagaa atgttgctgg tgaatttata agaatgtggt   1260

atgatactag taatgaaggc aaaatggaca gtgaagttta acacaactga actctaagaa   1320

aatcaaccat taatctctca ttttcatctg caaattgaag caacagttta gtttcaaacc   1380

tagctccctg ggtggaatga cgacttcact atacttagtg aatatccttt aagagctggg   1440

atttttttca agacaacaaa gatcattcat ttggttcttt atactatgaa acttgagtaa   1500

gtattacctc cttaattttt aacaactaag aacaaaaatt aacgagaaaa acaacaaagt   1560

acagatttat acataaacct aaaagcattt gaacatgaca cccgaacaca tacatatatg   1620

ttcacttatt tgtggcagaa ggtgatcaga taagctccag cccaaatgga acctgtgggg   1680

tggtattttg cattgcaagg agacgcaaaa ttttatttta aaactgtcct ccataataat   1740

caaacggtga ttcatctaaa tgacttctag caacctaagt aaaaacattc ccctcctatg   1800

tatgattcat ttgatcatat aaaacatcat gatggctcta attcataaat acaaaaatat   1860

atttaagtct ttatagatat aaagctttac ttagatataa cttgagtgag tagggaaaaa   1920

aatctacagt agataaagca aaagataatt aggcaacaaa gcattttcaa actcaaattc   1980

ctgtttccaa cttcaaatag ttttttctat aaacacaaaa tcagtgttta ttcaccagta   2040

ggaggttgga ctagatgaac tctattattt ctttctaaat ctaatagtct ataaaaatta   2100

tgtttcctct gttttttatt ttatctatgc taaaatgagc cctttccctt atgtccagtt   2160

taagatgatc atttgcatga ttttcatttc aataaaaaaa agagaaactg tccttaaaac   2220

aaaacaaaaa ccaaaaaagt caccctatca ggtttcaaac agatttgtgg ctgttctttt   2280

ctgaaatttc ccttattcag gtttctgtgg gaaaaatgaa agattaacct tccccactgg   2340

tgatgaccta ggcaggaatc atctcttgaa ataaatacta gctgagtaaa ggcaagcagg   2400

tgtgaagagc agggctcagc agcaagtcac atttttctac tatttgacca aaaggaaaag   2460

aaaataaaga agaactctgg agtggtctaa gactgataat agcagaagaa tatcaagaac   2520

acagaaactt aattattgtg aacttttgct gtttgaaaat cttagacatt cattcttaag   2580

tagaaatcag accaacagat tttcccaacc caagactatt gtaacacata aagacagcaa   2640

gaattcttat ttctataata aattaacaag attcacctaa cctttgaaaa taaagtagta   2700

ttgaagactt acatggtatg ttttttccta aaggcactac atcacttaca cagttcaccc   2760

tctcgcttgt taagtgaagc tgcccaaggt gacataagtg aatgagtaaa acctgagatc   2820

taag                                                                2824


<210>  68
<211>  94
<212>  PRT
<213>  Homosapiens

<400>  68

Met Asp Ser Ser Asn Cys Lys Val Ile Ala Pro Leu Leu Ser Gln Arg 
1               5                   10                  15      


Tyr Arg Arg Met Val Thr Lys Asp Gly His Ser Thr Leu Gln Met Asp 
            20                  25                  30          


Gly Ala Gln Arg Gly Leu Ala Tyr Leu Arg Asp Ala Trp Gly Ile Leu 
        35                  40                  45              


Met Asp Met Arg Trp Arg Trp Met Met Leu Val Phe Ser Ala Ser Phe 
    50                  55                  60                  


Val Val His Trp Leu Val Phe Ala Val Leu Trp Cys Phe Cys Gly Glu 
65                  70                  75                  80  


Asp Cys Pro Ala Lys Lys Ser Ser Phe Phe Asn Ser Leu Tyr 
                85                  90                  


<210>  69
<211>  2946
<212>  DNA
<213>  Homosapiens

<400>  69
agtccaagaa gagaacctac aaactagact tgtagattaa aattatctga tcaaaaaggc     60

agactctgta aatttcctta agacctacct tggcataaag gctgacccag caaaagaact    120

gagaaataca gcctgagatg gacagcagta attgcaaagt tattgctcct ctcctaagtc    180

aaagataccg gaggatggtc accaaggatg gccacagcac acttcaaatg gatggcgctc    240

aaagaggtct tgcatatctt cgagatgctt ggggaatcct aatggacatg cgctggcgtt    300

ggatgatgtt ggtcttttct gcttcttttg ttgtccactg gcttgtcttt gcagtgctct    360

ggtatgttct ggctgagatg aatggtgatc tggaactaga tcatgatgcc ccacctgaaa    420

accacactat ctgtgtcaag tatatcacca gtttcacagc tgcattctcc ttctccctgg    480

agacacaact cacaattggt tatggtacca tgttccccag tggtgactgt ccaagtgcaa    540

tcgccttact tgccatacaa atgctcctag gcctcatgct agaggctttt atcacaggtg    600

cttttgtggc gaagattgcc cggccaaaaa atcgagcttt ttcaattcgc tttactgaca    660

cagcagtagt agctcacatg gatggcaaac ctaatcttat cttccaagtg gccaacaccc    720

gacctagccc tctaaccagt gtccgggtct cagctgtact ctatcaggaa agagaaaatg    780

gcaaactcta ccagaccagt gtggatttcc accttgatgg catcagttct gacgaatgtc    840

cattcttcat ctttccacta acgtactatc actccattac accatcaagt cctctggcta    900

ctctgctcca gcatgaaaat ccttctcact ttgaattagt tgtattcctt tcagcaatgc    960

aggagggcac tggagaaata tgccaaagga ggacatccta cctaccgtct gaaatcatgt   1020

tacatcactg ttttgcatct ctgttgaccc gaggttccaa aggtgaatat caaatcaaga   1080

tggagaattt tgacaagact gtccctgaat ttccaactcc tctggtttct aaaagcccaa   1140

acaggactga cctggatatc cacatcaatg gacaaagcat tgacaatttt cagatctctg   1200

aaacaggact gacagaataa gacttatcca ttttttaatg tattaaatac acccagccag   1260

ttatgcagct actttttctt tactgtatct catgttttct tttttcaatg ctaattatag   1320

ctctctacat cacggtaatc atgcctatgc ctacataaga atggctgagc taacaataca   1380

cattctggaa acataacact ctacattaca aagtttgtta cctgctgaaa tcaatgtaac   1440

tcaacttgac agacacttat acagaaatgt tgctggtgaa tttataagaa tgtggtatga   1500

tactagtaat gaaggcaaaa tggacagtga agtttaacac aactgaactc taagaaaatc   1560

aaccattaat ctctcatttt catctgcaaa ttgaagcaac agtttagttt caaacctagc   1620

tccctgggtg gaatgacgac ttcactatac ttagtgaata tcctttaaga gctgggattt   1680

ttttcaagac aacaaagatc attcatttgg ttctttatac tatgaaactt gagtaagtat   1740

tacctcctta atttttaaca actaagaaca aaaattaacg agaaaaacaa caaagtacag   1800

atttatacat aaacctaaaa gcatttgaac atgacacccg aacacataca tatatgttca   1860

cttatttgtg gcagaaggtg atcagataag ctccagccca aatggaacct gtggggtggt   1920

attttgcatt gcaaggagac gcaaaatttt attttaaaac tgtcctccat aataatcaaa   1980

cggtgattca tctaaatgac ttctagcaac ctaagtaaaa acattcccct cctatgtatg   2040

attcatttga tcatataaaa catcatgatg gctctaattc ataaatacaa aaatatattt   2100

aagtctttat agatataaag ctttacttag atataacttg agtgagtagg gaaaaaaatc   2160

tacagtagat aaagcaaaag ataattaggc aacaaagcat tttcaaactc aaattcctgt   2220

ttccaacttc aaatagtttt ttctataaac acaaaatcag tgtttattca ccagtaggag   2280

gttggactag atgaactcta ttatttcttt ctaaatctaa tagtctataa aaattatgtt   2340

tcctctgttt tttattttat ctatgctaaa atgagccctt tcccttatgt ccagtttaag   2400

atgatcattt gcatgatttt catttcaata aaaaaaagag aaactgtcct taaaacaaaa   2460

caaaaaccaa aaaagtcacc ctatcaggtt tcaaacagat ttgtggctgt tcttttctga   2520

aatttccctt attcaggttt ctgtgggaaa aatgaaagat taaccttccc cactggtgat   2580

gacctaggca ggaatcatct cttgaaataa atactagctg agtaaaggca agcaggtgtg   2640

aagagcaggg ctcagcagca agtcacattt ttctactatt tgaccaaaag gaaaagaaaa   2700

taaagaagaa ctctggagtg gtctaagact gataatagca gaagaatatc aagaacacag   2760

aaacttaatt attgtgaact tttgctgttt gaaaatctta gacattcatt cttaagtaga   2820

aatcagacca acagattttc ccaacccaag actattgtaa cacataaaga cagcaagaat   2880

tcttatttct ataataaatt aacaagattc acctaacctt tgaaaataaa gtagtattga   2940

agactt                                                              2946


<210>  70
<211>  360
<212>  PRT
<213>  Homosapiens

<400>  70

Met Asp Ser Ser Asn Cys Lys Val Ile Ala Pro Leu Leu Ser Gln Arg 
1               5                   10                  15      


Tyr Arg Arg Met Val Thr Lys Asp Gly His Ser Thr Leu Gln Met Asp 
            20                  25                  30          


Gly Ala Gln Arg Gly Leu Ala Tyr Leu Arg Asp Ala Trp Gly Ile Leu 
        35                  40                  45              


Met Asp Met Arg Trp Arg Trp Met Met Leu Val Phe Ser Ala Ser Phe 
    50                  55                  60                  


Val Val His Trp Leu Val Phe Ala Val Leu Trp Tyr Val Leu Ala Glu 
65                  70                  75                  80  


Met Asn Gly Asp Leu Glu Leu Asp His Asp Ala Pro Pro Glu Asn His 
                85                  90                  95      


Thr Ile Cys Val Lys Tyr Ile Thr Ser Phe Thr Ala Ala Phe Ser Phe 
            100                 105                 110         


Ser Leu Glu Thr Gln Leu Thr Ile Gly Tyr Gly Thr Met Phe Pro Ser 
        115                 120                 125             


Gly Asp Cys Pro Ser Ala Ile Ala Leu Leu Ala Ile Gln Met Leu Leu 
    130                 135                 140                 


Gly Leu Met Leu Glu Ala Phe Ile Thr Gly Ala Phe Val Ala Lys Ile 
145                 150                 155                 160 


Ala Arg Pro Lys Asn Arg Ala Phe Ser Ile Arg Phe Thr Asp Thr Ala 
                165                 170                 175     


Val Val Ala His Met Asp Gly Lys Pro Asn Leu Ile Phe Gln Val Ala 
            180                 185                 190         


Asn Thr Arg Pro Ser Pro Leu Thr Ser Val Arg Val Ser Ala Val Leu 
        195                 200                 205             


Tyr Gln Glu Arg Glu Asn Gly Lys Leu Tyr Gln Thr Ser Val Asp Phe 
    210                 215                 220                 


His Leu Asp Gly Ile Ser Ser Asp Glu Cys Pro Phe Phe Ile Phe Pro 
225                 230                 235                 240 


Leu Thr Tyr Tyr His Ser Ile Thr Pro Ser Ser Pro Leu Ala Thr Leu 
                245                 250                 255     


Leu Gln His Glu Asn Pro Ser His Phe Glu Leu Val Val Phe Leu Ser 
            260                 265                 270         


Ala Met Gln Glu Gly Thr Gly Glu Ile Cys Gln Arg Arg Thr Ser Tyr 
        275                 280                 285             


Leu Pro Ser Glu Ile Met Leu His His Cys Phe Ala Ser Leu Leu Thr 
    290                 295                 300                 


Arg Gly Ser Lys Gly Glu Tyr Gln Ile Lys Met Glu Asn Phe Asp Lys 
305                 310                 315                 320 


Thr Val Pro Glu Phe Pro Thr Pro Leu Val Ser Lys Ser Pro Asn Arg 
                325                 330                 335     


Thr Asp Leu Asp Ile His Ile Asn Gly Gln Ser Ile Asp Asn Phe Gln 
            340                 345                 350         


Ile Ser Glu Thr Gly Leu Thr Glu 
        355                 360 


<210>  71
<211>  2710
<212>  DNA
<213>  Homosapiens

<400>  71
agtccaagaa gagaacctac aaactagact tgtagattaa aattatctga tcaaaaaggc     60

agactctgta aatttcctta agacctacct tggcataaag gctgacccag caaaagaact    120

gagaaataca gcctgagatg gacagcagta attgcaaagt tattgctcct ctcctaagtc    180

aaagataccg gaggatggtc accaaggatg gccacagcac acttcaaatg gatggcgctc    240

aaagaggtct tgcatatctt cgagatgctt ggggaatcct aatggacatg cgctggcgtt    300

ggatgatgtt ggtcttttct gcttcttttg ttgtccactg gcttgtcttt gcagtgctct    360

ggtgcttttg tggcgaagat tgcccggcca aaaaatcgag ctttttcaat tcgctttact    420

gacacagcag tagtagctca catggatggc aaacctaatc ttatcttcca agtggccaac    480

acccgaccta gccctctaac cagtgtccgg gtctcagctg tactctatca ggaaagagaa    540

aatggcaaac tctaccagac cagtgtggat ttccaccttg atggcatcag ttctgacgaa    600

tgtccattct tcatctttcc actaacgtac tatcactcca ttacaccatc aagtcctctg    660

gctactctgc tccagcatga aaatccttct cactttgaat tagttgtatt cctttcagca    720

atgcaggagg gcactggaga aatatgccaa aggaggacat cctacctacc gtctgaaatc    780

atgttacatc actgttttgc atctctgttg acccgaggtt ccaaaggtga atatcaaatc    840

aagatggaga attttgacaa gactgtccct gaatttccaa ctcctctggt ttctaaaagc    900

ccaaacagga ctgacctgga tatccacatc aatggacaaa gcattgacaa ttttcagatc    960

tctgaaacag gactgacaga ataagactta tccatttttt aatgtattaa atacacccag   1020

ccagttatgc agctactttt tctttactgt atctcatgtt ttcttttttc aatgctaatt   1080

atagctctct acatcacggt aatcatgcct atgcctacat aagaatggct gagctaacaa   1140

tacacattct ggaaacataa cactctacat tacaaagttt gttacctgct gaaatcaatg   1200

taactcaact tgacagacac ttatacagaa atgttgctgg tgaatttata agaatgtggt   1260

atgatactag taatgaaggc aaaatggaca gtgaagttta acacaactga actctaagaa   1320

aatcaaccat taatctctca ttttcatctg caaattgaag caacagttta gtttcaaacc   1380

tagctccctg ggtggaatga cgacttcact atacttagtg aatatccttt aagagctggg   1440

atttttttca agacaacaaa gatcattcat ttggttcttt atactatgaa acttgagtaa   1500

gtattacctc cttaattttt aacaactaag aacaaaaatt aacgagaaaa acaacaaagt   1560

acagatttat acataaacct aaaagcattt gaacatgaca cccgaacaca tacatatatg   1620

ttcacttatt tgtggcagaa ggtgatcaga taagctccag cccaaatgga acctgtgggg   1680

tggtattttg cattgcaagg agacgcaaaa ttttatttta aaactgtcct ccataataat   1740

caaacggtga ttcatctaaa tgacttctag caacctaagt aaaaacattc ccctcctatg   1800

tatgattcat ttgatcatat aaaacatcat gatggctcta attcataaat acaaaaatat   1860

atttaagtct ttatagatat aaagctttac ttagatataa cttgagtgag tagggaaaaa   1920

aatctacagt agataaagca aaagataatt aggcaacaaa gcattttcaa actcaaattc   1980

ctgtttccaa cttcaaatag ttttttctat aaacacaaaa tcagtgttta ttcaccagta   2040

ggaggttgga ctagatgaac tctattattt ctttctaaat ctaatagtct ataaaaatta   2100

tgtttcctct gttttttatt ttatctatgc taaaatgagc cctttccctt atgtccagtt   2160

taagatgatc atttgcatga ttttcatttc aataaaaaaa agagaaactg tccttaaaac   2220

aaaacaaaaa ccaaaaaagt caccctatca ggtttcaaac agatttgtgg ctgttctttt   2280

ctgaaatttc ccttattcag gtttctgtgg gaaaaatgaa agattaacct tccccactgg   2340

tgatgaccta ggcaggaatc atctcttgaa ataaatacta gctgagtaaa ggcaagcagg   2400

tgtgaagagc agggctcagc agcaagtcac atttttctac tatttgacca aaaggaaaag   2460

aaaataaaga agaactctgg agtggtctaa gactgataat agcagaagaa tatcaagaac   2520

acagaaactt aattattgtg aacttttgct gtttgaaaat cttagacatt cattcttaag   2580

tagaaatcag accaacagat tttcccaacc caagactatt gtaacacata aagacagcaa   2640

gaattcttat ttctataata aattaacaag attcacctaa cctttgaaaa taaagtagta   2700

ttgaagactt                                                          2710


<210>  72
<211>  94
<212>  PRT
<213>  Homosapiens

<400>  72

Met Asp Ser Ser Asn Cys Lys Val Ile Ala Pro Leu Leu Ser Gln Arg 
1               5                   10                  15      


Tyr Arg Arg Met Val Thr Lys Asp Gly His Ser Thr Leu Gln Met Asp 
            20                  25                  30          


Gly Ala Gln Arg Gly Leu Ala Tyr Leu Arg Asp Ala Trp Gly Ile Leu 
        35                  40                  45              


Met Asp Met Arg Trp Arg Trp Met Met Leu Val Phe Ser Ala Ser Phe 
    50                  55                  60                  


Val Val His Trp Leu Val Phe Ala Val Leu Trp Cys Phe Cys Gly Glu 
65                  70                  75                  80  


Asp Cys Pro Ala Lys Lys Ser Ser Phe Phe Asn Ser Leu Tyr 
                85                  90                  


<210>  73
<211>  1270
<212>  DNA
<213>  Homosapiens

<400>  73
agtccaagaa gagaacctac aaactagact tgtagattaa aattatctga tcaaaaaggc     60

agactctgta aatttcctta agacctacct tggcataaag gctgacccag caaaagaact    120

gagaaataca gcctgagatg gacagcagta attgcaaagt tattgctcct ctcctaagtc    180

aaagataccg gaggatggtc accaaggatg gccacagcac acttcaaatg gatggcgctc    240

aaagaggtct tgcatatctt cgagatgctt ggggaatcct aatggacatg cgctggcgtt    300

ggatgatgtt ggtcttttct gcttcttttg ttgtccactg gcttgtcttt gcagtgctct    360

ggtatgttct ggctgagatg aatggtgatc tggaactaga tcatgatgcc ccacctgaaa    420

accacactat ctgtgtcaag tatatcacca gtttcacagc tgcattctcc ttctccctgg    480

agacacaact cacaattggt tatggtacca tgttccccag tggtgactgt ccaagtgcaa    540

tcgccttact tgccatacaa atgctcctag gcctcatgct agaggctttt atcacaggtg    600

cttttgtggc gaagattgcc cggccaaaaa atcgagcttt ttcaattcgc tttactgaca    660

cagcagtagt agctcacatg gatggcaaac ctaatcttat cttccaagtg gccaacaccc    720

gacctagccc tctaaccagt gtccgggtct cagctgtact ctatcaggaa agagaaaatg    780

gcaaactcta ccagaccagt gtggatttcc accttgatgg catcagttct gacgaatgtc    840

cattcttcat ctttccacta acgtactatc actccattac accatcaagt cctctggcta    900

ctctgctcca gcatgaaaat ccttctcact ttgaattagt tgtattcctt tcagcaatgc    960

aggagggcac tggagaaata tgccaaagga ggacatccta cctaccgtct gaaatcatgt   1020

tacatcactg ttttgcatct ctgttgaccc gaggttccaa aggtgaatat caaatcaaga   1080

tggagaattt tgacaagact gtccctgaat ttccaactcc tctggtttct aaaagcccaa   1140

acaggactga cctggatatc cacatcaatg gacaaagcat tgacaatttt cagatctctg   1200

aaacaggact gacagaataa gacttatcca ttttttaatg tattaaatac acccagccag   1260

ttatgcagct                                                          1270


<210>  74
<211>  360
<212>  PRT
<213>  Homosapiens

<400>  74

Met Asp Ser Ser Asn Cys Lys Val Ile Ala Pro Leu Leu Ser Gln Arg 
1               5                   10                  15      


Tyr Arg Arg Met Val Thr Lys Asp Gly His Ser Thr Leu Gln Met Asp 
            20                  25                  30          


Gly Ala Gln Arg Gly Leu Ala Tyr Leu Arg Asp Ala Trp Gly Ile Leu 
        35                  40                  45              


Met Asp Met Arg Trp Arg Trp Met Met Leu Val Phe Ser Ala Ser Phe 
    50                  55                  60                  


Val Val His Trp Leu Val Phe Ala Val Leu Trp Tyr Val Leu Ala Glu 
65                  70                  75                  80  


Met Asn Gly Asp Leu Glu Leu Asp His Asp Ala Pro Pro Glu Asn His 
                85                  90                  95      


Thr Ile Cys Val Lys Tyr Ile Thr Ser Phe Thr Ala Ala Phe Ser Phe 
            100                 105                 110         


Ser Leu Glu Thr Gln Leu Thr Ile Gly Tyr Gly Thr Met Phe Pro Ser 
        115                 120                 125             


Gly Asp Cys Pro Ser Ala Ile Ala Leu Leu Ala Ile Gln Met Leu Leu 
    130                 135                 140                 


Gly Leu Met Leu Glu Ala Phe Ile Thr Gly Ala Phe Val Ala Lys Ile 
145                 150                 155                 160 


Ala Arg Pro Lys Asn Arg Ala Phe Ser Ile Arg Phe Thr Asp Thr Ala 
                165                 170                 175     


Val Val Ala His Met Asp Gly Lys Pro Asn Leu Ile Phe Gln Val Ala 
            180                 185                 190         


Asn Thr Arg Pro Ser Pro Leu Thr Ser Val Arg Val Ser Ala Val Leu 
        195                 200                 205             


Tyr Gln Glu Arg Glu Asn Gly Lys Leu Tyr Gln Thr Ser Val Asp Phe 
    210                 215                 220                 


His Leu Asp Gly Ile Ser Ser Asp Glu Cys Pro Phe Phe Ile Phe Pro 
225                 230                 235                 240 


Leu Thr Tyr Tyr His Ser Ile Thr Pro Ser Ser Pro Leu Ala Thr Leu 
                245                 250                 255     


Leu Gln His Glu Asn Pro Ser His Phe Glu Leu Val Val Phe Leu Ser 
            260                 265                 270         


Ala Met Gln Glu Gly Thr Gly Glu Ile Cys Gln Arg Arg Thr Ser Tyr 
        275                 280                 285             


Leu Pro Ser Glu Ile Met Leu His His Cys Phe Ala Ser Leu Leu Thr 
    290                 295                 300                 


Arg Gly Ser Lys Gly Glu Tyr Gln Ile Lys Met Glu Asn Phe Asp Lys 
305                 310                 315                 320 


Thr Val Pro Glu Phe Pro Thr Pro Leu Val Ser Lys Ser Pro Asn Arg 
                325                 330                 335     


Thr Asp Leu Asp Ile His Ile Asn Gly Gln Ser Ile Asp Asn Phe Gln 
            340                 345                 350         


Ile Ser Glu Thr Gly Leu Thr Glu 
        355                 360 


<210>  75
<211>  5219
<212>  DNA
<213>  Homosapiens

<400>  75
accagcagtt tttaatacag taagaagagt aatgcagtag gatgtactgc agcatgaaaa     60

aggactttaa atagaatctg ctctcaagtc tcacctttta cagtagagag gactaacggc    120

ttatatggca cttcagtcac ccagctagtg gcgtcttgcc accatacctt ctaattttag    180

tgttgtcatt tatttattta tttatttatt tttgagacag agcctcactc tgtcatccag    240

gctggagtgc agtggcatga tctcggctca ctgcaacctc tgccttcctg gttccattga    300

ttctcgtgct tcagcctcct gagtagctgg gactacaggc gtgtgccacc acgcccagcc    360

tatttttgta tttttagtag agatggggtt ttactgtgtt ggcgaggctg gcctcgaact    420

cccagcctca agtgatctgc ctgcctcgcc tcccaaagtg ctgggattac aggcatgaac    480

caccactcct ggcttatctt acttttaaat accagaagtt tagaagatga cacataactt    540

taattttgta agctctttag tttctaagtg cctcctgagt ggctcagctt tgaatgccac    600

agaggaaaaa aaatatatat gtatataagc gagagggtgg gaaagaagtt aaagttaatt    660

attttaggag tggtgtggaa tgatggcaaa gtcagtcagg ttttgttatg tcctttttgt    720

agaagaaata agatttgctg ttcttgtggt gcagaggttg gcaaagtctg acctttgggc    780

taaatctggc ctgctctcta tttttatatt tataagcaaa gtgttactga aacagacaca    840

cctgttggtt tgtaggatgt atattgctgc ttttgcctta tgatggcaga attgagtagt    900

tgcaacagag agtatatgag ctgcatagat gaaactattt actctctggc ccattacaaa    960

agtttaaccc tgatctagtg aagaaaaatt acctaaattt ttccaagttg aagacgatca   1020

atgtatgaat ttttatagaa gtgttacatt ttttacaaag ggtacgtcat atggttaaag   1080

ctactaattt gaatctgttt catttttcat ttgatttctg ataaaaggtt atctttggag   1140

tttaccaatt tttgacattc gtgattttaa aaatattttc tctgaataga ccactttgca   1200

ctgaattgtg aatttttttg ctatcctctt tcactcggaa acacgccatc tatgagttca   1260

gttctttcta gaatgaagca tagaattttc tatgtgtcta ttatcataat gaagaattat   1320

aaaatatatt tgatagctat ttctaataat gtctcctggg gggctttgaa ttgaactttg   1380

tctttcagca tctcagccat gtgaactaag tgtggattga caggttatac tttttttttt   1440

actttttgaa gacaacaata tgcacaggtt ttggcccaac agcagaaagc agcactgtct   1500

tcccagcagc agcagcagtt ggcacttctt cttcaacagt ttcagacctt gaagatgaga   1560

atatctgatc agaacatcat tccctcagta actaggtctg tgtccgtgcc agatactggc   1620

tctatctggg agcttcagcc aacagcttca cagcctacag tttgggaagg tggtagtgta   1680

tgggatcttc ctctggacac cacgacacca ggccctgccc tggaacagct tcagcagcta   1740

gagaaggcca aagctgcaaa gctagagcaa gagagaagag aggcagaaat gagggcaaaa   1800

cgggaagagg aagagcgaaa gaggcaggaa gaactccgaa gacaacagga ggaaattctt   1860

cggcgacagc aggaagaaga aaggaaaagg cgagaggaag aagaacttgc ccgaaggaaa   1920

caggaagagg ctctgcgtcg ccagcgggag caagaaattg cattaaggcg acagcgagaa   1980

gaggaagaaa gacagcagca agaagaagct cttagaagac tggaagagag gagaagagaa   2040

gaggaagaaa ggcggaagca ggaagaattg ttacgcaaac aggaagagga ggctgcaaaa   2100

tgggcccggg aagaagaaga agcccagcgt cgattagagg agaaccggct gcggatggaa   2160

gaggaggcag ccagactccg gcatgaggaa gaagaacgga agagaaagga gctggaggtc   2220

cagcggcaga aggagttaat gcgccagagg cagcagcagc aagaggctct ccggaggttg   2280

cagcagcagc agcagcaaca acagctggcg cagatgaagc ttccttcttc ttcaacgtgg   2340

ggccagcagt ccaatacaac agcatgtcag tcccaggcca cgctgtcgtt ggctgaaatc   2400

caaaaactag aggaagaacg agaacggcag cttcgagaag agcaaaggcg ccagcagagg   2460

gagttgatga aagctcttca gcagcagcag caacagcaac agcagaaact ctcaggttgg   2520

gggaatgtca gcaaaccttc aggtaccacg aaatctcttc tggagatcca gcaggaagag   2580

gccaggcaaa tgcaaaagca gcagcagcag cagcagcaac accagcaacc aaacagagct   2640

cgtaacaata cgcattccaa cctgcacacc agcattggga attctgtttg gggctctata   2700

aatactggtc ctcctaacca gtgggcatct gacctagtca gtagtatttg gagtaatgct   2760

gacactaaaa actccaacat gggattctgg gatgatgcag tgaaagaggt gggacctagg   2820

aattcaacaa ataaaaataa aaacaacgcc agtctcagta aatctgtagg tgtgtctaac   2880

cggcagaata agaaagtaga agaagaagaa aagttgctga agctctttca gggagtaaat   2940

aaagcccaag atggatttac gcagtggtgt gaacagatgc ttcatgccct taatacggca   3000

aataacttgg atgttcccac atttgtttct ttcctgaaag aagtagaatc tccttatgag   3060

gtccatgatt atatcagggc ctatttagga gatacttctg aggccaagga gtttgccaag   3120

cagttccttg agcgccgtgc caaacagaaa gccaaccagc agcgtcagca gcagcagctg   3180

ccacagcagc agcagcagca gccgccacag cagccgccac agcagccaca acagcaggac   3240

tctgtgtggg ggatgaacca cagtacactc cattcagtat ttcagaccaa tcaaagcaac   3300

aaccaacaat ccaattttga ggctgtgcag agtggcaaga agaagaaaaa gcagaagatg   3360

gtccgagcag atcccagttt attaggattt tcagtcaatg catcatcgga gcgactcaac   3420

atgggtgaaa tcgagacgtt ggatgactac tgagcacctg ccagtggact ggccatccct   3480

ctcctgtctg ccgactatgg agtctccacc tttggacaca acacttactc accatttact   3540

ctttatcact ctgcaacaaa tcacagaacc gatcatctca ggctttttct tctggccctt   3600

tgtgtccaag attctttaat ccatttttgt tggtgaacat ctcagactat agataagtgg   3660

actggaccct gtgtcttggg ggtggcagtt gggattactc cccaacaagg ctgattttag   3720

gcagcatgtg ttcactgtgc tgtgatttca tctactgtct cccagaaagt gtgttgggat   3780

cggccattag cagcttgctt tctcttgtca ctttttttct tctattttgt tttttcttct   3840

tctttttccc cccatcaggg caaatggtct aactggtgca atcatgaaga gagttaatgg   3900

ttaacagaca ttggccaata acaaaacacc ccatggactg tgactcgagt atccaacagg   3960

cagtcagagc tctcccggtc tgaaagttgc attgccactg ctaactttgg gattgcatca   4020

gagaggccct gagtggggtt gagatgaggt tggtttggtt tgatgttaca cactcctcac   4080

ctgttctttc tgagtgtcct ttctctgaaa ggatttatgt ttttcttcgt tagatagtga   4140

cttctgagca agctgatctc ccctggcatg ctccaacctg attggacaaa ggaagctcta   4200

tggcctggga gagagactat tcttaatttt tctttcttac aaaaactgat ttttcccata   4260

aatattttta cttcagagga ctaggaccat tttgttttgg gcccttctgc tgaaaatttg   4320

tctcgtttaa gaggcagcta gaatctttac catatgtatg aatttgtata atttcatttt   4380

tggataggga taaacttttg cttctgataa aagcctggaa tttcatctgg tcctcagagc   4440

attgcgtgtg tgtcttgctg tagcccggaa aaggttttgt gtaaagattc tgggatggca   4500

agttgtttgc cttttctgaa aagagaacat acagaacctg tccatcttta agaccttcat   4560

ccatggaatc tactatacag gaggatgcag tgggctggag gggatgggcg aaaatgggag   4620

caggaagcct ggcctggctt ctggtcatgg cctcctaaaa ccttaaactt caagtagaaa   4680

tgtactcaag ccctatttat aaacaaatac ttttcctgcc tccaccaaac ccctacagaa   4740

catcacctgg aattgccact cacactgggt tggagtcatt gggcagctgt gcctgtgcga   4800

gaggtgctgt ggtctgggca gcccctggaa aagcaccttt gctgcctgtc attgttgcct   4860

gaagaaggct ggagttgctc tgagagcagt ttgggtttgg agtattatat ttggcttcta   4920

tttttattat tttggatcac cattctccct atcccttctt gcctccctcc cttctaaaca   4980

tgtgtaataa ctatacagag actgctacaa aattgtatat agtttttgga tcaaatagca   5040

tgaggggaga ggaaaccatt aaaagttggg gctcctactc tcctttgctt tgtaaattca   5100

aaagttgggg gtgggtaaga gggatagtta aaatgtttac aaaactttag gctccctcgg   5160

aacttttgcc agtgtggagg aaaataaaaa agaacttaaa taaaatctga ttgtattct    5219


<210>  76
<211>  632
<212>  PRT
<213>  Homosapiens

<400>  76

Met Arg Ile Ser Asp Gln Asn Ile Ile Pro Ser Val Thr Arg Ser Val 
1               5                   10                  15      


Ser Val Pro Asp Thr Gly Ser Ile Trp Glu Leu Gln Pro Thr Ala Ser 
            20                  25                  30          


Gln Pro Thr Val Trp Glu Gly Gly Ser Val Trp Asp Leu Pro Leu Asp 
        35                  40                  45              


Thr Thr Thr Pro Gly Pro Ala Leu Glu Gln Leu Gln Gln Leu Glu Lys 
    50                  55                  60                  


Ala Lys Ala Ala Lys Leu Glu Gln Glu Arg Arg Glu Ala Glu Met Arg 
65                  70                  75                  80  


Ala Lys Arg Glu Glu Glu Glu Arg Lys Arg Gln Glu Glu Leu Arg Arg 
                85                  90                  95      


Gln Gln Glu Glu Ile Leu Arg Arg Gln Gln Glu Glu Glu Arg Lys Arg 
            100                 105                 110         


Arg Glu Glu Glu Glu Leu Ala Arg Arg Lys Gln Glu Glu Ala Leu Arg 
        115                 120                 125             


Arg Gln Arg Glu Gln Glu Ile Ala Leu Arg Arg Gln Arg Glu Glu Glu 
    130                 135                 140                 


Glu Arg Gln Gln Gln Glu Glu Ala Leu Arg Arg Leu Glu Glu Arg Arg 
145                 150                 155                 160 


Arg Glu Glu Glu Glu Arg Arg Lys Gln Glu Glu Leu Leu Arg Lys Gln 
                165                 170                 175     


Glu Glu Glu Ala Ala Lys Trp Ala Arg Glu Glu Glu Glu Ala Gln Arg 
            180                 185                 190         


Arg Leu Glu Glu Asn Arg Leu Arg Met Glu Glu Glu Ala Ala Arg Leu 
        195                 200                 205             


Arg His Glu Glu Glu Glu Arg Lys Arg Lys Glu Leu Glu Val Gln Arg 
    210                 215                 220                 


Gln Lys Glu Leu Met Arg Gln Arg Gln Gln Gln Gln Glu Ala Leu Arg 
225                 230                 235                 240 


Arg Leu Gln Gln Gln Gln Gln Gln Gln Gln Leu Ala Gln Met Lys Leu 
                245                 250                 255     


Pro Ser Ser Ser Thr Trp Gly Gln Gln Ser Asn Thr Thr Ala Cys Gln 
            260                 265                 270         


Ser Gln Ala Thr Leu Ser Leu Ala Glu Ile Gln Lys Leu Glu Glu Glu 
        275                 280                 285             


Arg Glu Arg Gln Leu Arg Glu Glu Gln Arg Arg Gln Gln Arg Glu Leu 
    290                 295                 300                 


Met Lys Ala Leu Gln Gln Gln Gln Gln Gln Gln Gln Gln Lys Leu Ser 
305                 310                 315                 320 


Gly Trp Gly Asn Val Ser Lys Pro Ser Gly Thr Thr Lys Ser Leu Leu 
                325                 330                 335     


Glu Ile Gln Gln Glu Glu Ala Arg Gln Met Gln Lys Gln Gln Gln Gln 
            340                 345                 350         


Gln Gln Gln His Gln Gln Pro Asn Arg Ala Arg Asn Asn Thr His Ser 
        355                 360                 365             


Asn Leu His Thr Ser Ile Gly Asn Ser Val Trp Gly Ser Ile Asn Thr 
    370                 375                 380                 


Gly Pro Pro Asn Gln Trp Ala Ser Asp Leu Val Ser Ser Ile Trp Ser 
385                 390                 395                 400 


Asn Ala Asp Thr Lys Asn Ser Asn Met Gly Phe Trp Asp Asp Ala Val 
                405                 410                 415     


Lys Glu Val Gly Pro Arg Asn Ser Thr Asn Lys Asn Lys Asn Asn Ala 
            420                 425                 430         


Ser Leu Ser Lys Ser Val Gly Val Ser Asn Arg Gln Asn Lys Lys Val 
        435                 440                 445             


Glu Glu Glu Glu Lys Leu Leu Lys Leu Phe Gln Gly Val Asn Lys Ala 
    450                 455                 460                 


Gln Asp Gly Phe Thr Gln Trp Cys Glu Gln Met Leu His Ala Leu Asn 
465                 470                 475                 480 


Thr Ala Asn Asn Leu Asp Val Pro Thr Phe Val Ser Phe Leu Lys Glu 
                485                 490                 495     


Val Glu Ser Pro Tyr Glu Val His Asp Tyr Ile Arg Ala Tyr Leu Gly 
            500                 505                 510         


Asp Thr Ser Glu Ala Lys Glu Phe Ala Lys Gln Phe Leu Glu Arg Arg 
        515                 520                 525             


Ala Lys Gln Lys Ala Asn Gln Gln Arg Gln Gln Gln Gln Leu Pro Gln 
    530                 535                 540                 


Gln Gln Gln Gln Gln Pro Pro Gln Gln Pro Pro Gln Gln Pro Gln Gln 
545                 550                 555                 560 


Gln Asp Ser Val Trp Gly Met Asn His Ser Thr Leu His Ser Val Phe 
                565                 570                 575     


Gln Thr Asn Gln Ser Asn Asn Gln Gln Ser Asn Phe Glu Ala Val Gln 
            580                 585                 590         


Ser Gly Lys Lys Lys Lys Lys Gln Lys Met Val Arg Ala Asp Pro Ser 
        595                 600                 605             


Leu Leu Gly Phe Ser Val Asn Ala Ser Ser Glu Arg Leu Asn Met Gly 
    610                 615                 620                 


Glu Ile Glu Thr Leu Asp Asp Tyr 
625                 630         


<210>  77
<211>  658
<212>  DNA
<213>  Homosapiens

<400>  77
gagccaggcc cagcctggaa atggatgtca taagtgcaca ggggtctagg gaggcagaga     60

gcgaaagagg aaacaggagc gttttaggaa agactagagc tgcctgaggg tttggatcaa    120

aactgcttta aaagtccttc ttcaacaagc actgagcacc tactccgggc caggcatgga    180

gaacccagag ttaaccagcg cagtcctccg tgcgtcccgc ccgccgctgc cctcactccc    240

ggccaggatg gcatcctgtc tggccctgcg catggcgctg ctgctggtct ccggggttct    300

ggcccctgcg gtgctcacag acgatgttcc acaggagccc gtgcccacgc tgtggaacga    360

gccggccgag ctgccgtcgg gagaaggccc cgtggagagc accagccccg gccgggagcc    420

cgtggacacc ggtcccccag cccccaccgt cgcgccagga cccgaggaca gcaccgcgca    480

ggagcggctg gaccagggcg gcgggtcgct ggggcccggc gctatcgcgg ccatcgtgat    540

cgccgccctg ctggccacct gcgtggtgct ggcgctcgtg gtcgtcgcgc tgagaaagtt    600

ttctgcctcc tgaagcgaat aaaggggccg cgcccggccg cggcgcgact cggctgca      658


<210>  78
<211>  145
<212>  PRT
<213>  Homosapiens

<400>  78

Met Glu Asn Pro Glu Leu Thr Ser Ala Val Leu Arg Ala Ser Arg Pro 
1               5                   10                  15      


Pro Leu Pro Ser Leu Pro Ala Arg Met Ala Ser Cys Leu Ala Leu Arg 
            20                  25                  30          


Met Ala Leu Leu Leu Val Ser Gly Val Leu Ala Pro Ala Val Leu Thr 
        35                  40                  45              


Asp Asp Val Pro Gln Glu Pro Val Pro Thr Leu Trp Asn Glu Pro Ala 
    50                  55                  60                  


Glu Leu Pro Ser Gly Glu Gly Pro Val Glu Ser Thr Ser Pro Gly Arg 
65                  70                  75                  80  


Glu Pro Val Asp Thr Gly Pro Pro Ala Pro Thr Val Ala Pro Gly Pro 
                85                  90                  95      


Glu Asp Ser Thr Ala Gln Glu Arg Leu Asp Gln Gly Gly Gly Ser Leu 
            100                 105                 110         


Gly Pro Gly Ala Ile Ala Ala Ile Val Ile Ala Ala Leu Leu Ala Thr 
        115                 120                 125             


Cys Val Val Leu Ala Leu Val Val Val Ala Leu Arg Lys Phe Ser Ala 
    130                 135                 140                 


Ser 
145 


<210>  79
<211>  468
<212>  DNA
<213>  Homosapiens

<400>  79
gccaagagcc gacctaccat ccccatgttg agctttccag cgtttctggg gcatcctgtc     60

tggttgccgg ggatggatgg cccagggttg gagtggtggt caggggagga caactggggt    120

gggctggctg acgatgttcc acaggagccc gtgcccacgc tgtggaacga gccggccgag    180

ctgccgtcgg gagaaggccc cgtggagagc accagccccg gccgggagcc cgtggacacc    240

ggtcccccag cccccaccgt cgcgccagga cccgaggaca gcaccgcgca ggagcggctg    300

gaccagggcg gcgggtcgct ggggcccggc gctatcgcgg ccatcgtgat cgccgccctg    360

ctggccacct gcgtggtgct ggcgctcgtg gtcgtcgcgc tgagaaagtt ttctgcctcc    420

tgaagcgaat aaaggggccg cgcccggccg cggcgcgact cggctgca                 468


<210>  80
<211>  132
<212>  PRT
<213>  Homosapiens

<400>  80

Met Leu Ser Phe Pro Ala Phe Leu Gly His Pro Val Trp Leu Pro Gly 
1               5                   10                  15      


Met Asp Gly Pro Gly Leu Glu Trp Trp Ser Gly Glu Asp Asn Trp Gly 
            20                  25                  30          


Gly Leu Ala Asp Asp Val Pro Gln Glu Pro Val Pro Thr Leu Trp Asn 
        35                  40                  45              


Glu Pro Ala Glu Leu Pro Ser Gly Glu Gly Pro Val Glu Ser Thr Ser 
    50                  55                  60                  


Pro Gly Arg Glu Pro Val Asp Thr Gly Pro Pro Ala Pro Thr Val Ala 
65                  70                  75                  80  


Pro Gly Pro Glu Asp Ser Thr Ala Gln Glu Arg Leu Asp Gln Gly Gly 
                85                  90                  95      


Gly Ser Leu Gly Pro Gly Ala Ile Ala Ala Ile Val Ile Ala Ala Leu 
            100                 105                 110         


Leu Ala Thr Cys Val Val Leu Ala Leu Val Val Val Ala Leu Arg Lys 
        115                 120                 125             


Phe Ser Ala Ser 
    130         


<210>  81
<211>  503
<212>  DNA
<213>  Homosapiens

<400>  81
ggcttcagct tcttagcctg ggaaatgtga gggctagtgc agcgctgagc ccagacccct     60

cacacagcgc taccggcaac ttgcttaacc tagaggtggg gggtgacgtc cctgtcggcc    120

ccgtcacctg gggccccagc acctctcctt ggctttgcag acgatgttcc acaggagccc    180

gtgcccacgc tgtggaacga gccggccgag ctgccgtcgg gagaaggccc cgtggagagc    240

accagccccg gccgggagcc cgtggacacc ggtcccccag cccccaccgt cgcgccagga    300

cccgaggaca gcaccgcgca ggagcggctg gaccagggcg gcgggtcgct ggggcccggc    360

gctatcgcgg ccatcgtgat cgccgccctg ctggccacct gcgtggtgct ggcgctcgtg    420

gtcgtcgcgc tgagaaagtt ttctgcctcc tgaagcgaat aaaggggccg cgcccggccg    480

cggcgcgact cggctgcact cct                                            503


<210>  82
<211>  71
<212>  PRT
<213>  Homosapiens

<400>  82

Met Phe His Arg Ser Pro Cys Pro Arg Cys Gly Thr Ser Arg Pro Ser 
1               5                   10                  15      


Cys Arg Arg Glu Lys Ala Pro Trp Arg Ala Pro Ala Pro Ala Gly Ser 
            20                  25                  30          


Pro Trp Thr Pro Val Pro Gln Pro Pro Pro Ser Arg Gln Asp Pro Arg 
        35                  40                  45              


Thr Ala Pro Arg Arg Ser Gly Trp Thr Arg Ala Ala Gly Arg Trp Gly 
    50                  55                  60                  


Pro Ala Leu Ser Arg Pro Ser 
65                  70      


<210>  83
<211>  1899
<212>  DNA
<213>  Homosapiens

<400>  83
ggcttcagct tcttagcctg ggaaatgtga gggctagtgc agcgctgagc ccagacccct     60

cacacagcgc taccggcaac ttgcttaacc tagaggtggg gggtgacgtc cctgtcggcc    120

ccgtcacctg gggccccagc acctctcctt ggctttgcag acgatgttcc acaggagccc    180

gtgcccacgc tgtggaacga gccggccgag ctgccgtcgg gagaaggccc cgtggagagc    240

accagccccg gccgggagcc cgtggacacc ggtcccccag cccccaccgt cgcgccagga    300

cccgaggaca gcaccgcgca ggagcggctg gaccagggcg gcgggtcgct ggggcccggc    360

gctatcgcgg ccatcgtgat cgccgccctg ctggccacct gcgtggtgct ggcgctcgtg    420

gtcgtcgcgc tgagaaagtt ttctgcctcc tgaagcgaat aaaggggccg cgcccggccg    480

cggcgcgact cggctgcact cctcacgcgc ctgtatgtcc gcgcgtgcgt gtccgcgcat    540

gcaggtgtgc cagagcgtga gcgcgcgcag gcgagcgctc agggcggggg tgcgcgcggg    600

gccgagggtg ggtgccgtgc acgcgcgcgg gtccggaggc gcgcccgaat tccccgcagg    660

ggcgccgggg cgtgcgtgag cgcacagcat gtccgagccc gcctgcgtgt ggcgtgcacc    720

tgagcgcgcg cagggccgcg cggctcggcg tccccgtgca ccacggctgg agtgcctcag    780

gagcgcgccg catgtgcgtg cccggtgcgc gtgcgccggg gccgccaggg catcggagcg    840

ggtgtgcggc cagcggtctt agcccgtccg ggggcaccgt cacggtcagg gccacgccac    900

gggcggcccc ttctcccggc gccgcctcct ctgcctgggc gcgggccgag gccctcgccg    960

cgctccccgg ggcctgcctc ccatcccgct ccgctggggt tcagagcgtt ccgtgaggag   1020

gtaagcgcta gggcaggaga ggccgacaga gaccccgggg cccgccgctc cttgaggccg   1080

gggttgggga gggcaggggc cgtcggctct cccagccaga ggccgcgtgg ttttggggga   1140

cgtcttgact ctgagtcctg cagccagggc cccatccgcg ggctcagacc agcagcccca   1200

agcccccctc tgcccaggga gcctcaggag caggatgagt cgagagtcga cgccggacac   1260

ggcccgcccc tgcttcctac tctcaccccc aggcctggct gggggccggc agcccccacg   1320

cccacggttg gtttgttcag ggagagaaaa cggctttccc agctctactc acctcacttc   1380

accctcagag agtcggggcg gagtgagggt gaggagcctg gtccagggtc cccacctcgg   1440

aagcatttag agatgtaaac tttgatcctt tgatcattta acctgctcag cacagcagga   1500

agtgggaact tggtccctac cccagtcccc agggcctttg gagggaaggg ttggacagtt   1560

tggaggccag cagacccctt ggggacagct taatgtatct gaagattcct gagtgggaat   1620

gttgctggag ggcaagctgc ttctcttttt taaaaattca ttttctctag cagctgtttt   1680

ggcccctttg gtgtccctga gctccccatg gcactgtttc ctgccgtgac tttctcctcc   1740

tggacactgg agcccaggtg gtgcccgcgc acctctcaca cactggggga tagggtcaag   1800

gcctcatcca agtctgttaa cagcttccca ctcaaccagt ctccccaaaa tacactgtga   1860

gttcaatgat tctgcttata aaggagtgct atgaaactg                          1899


<210>  84
<211>  71
<212>  PRT
<213>  Homosapiens

<400>  84

Met Phe His Arg Ser Pro Cys Pro Arg Cys Gly Thr Ser Arg Pro Ser 
1               5                   10                  15      


Cys Arg Arg Glu Lys Ala Pro Trp Arg Ala Pro Ala Pro Ala Gly Ser 
            20                  25                  30          


Pro Trp Thr Pro Val Pro Gln Pro Pro Pro Ser Arg Gln Asp Pro Arg 
        35                  40                  45              


Thr Ala Pro Arg Arg Ser Gly Trp Thr Arg Ala Ala Gly Arg Trp Gly 
    50                  55                  60                  


Pro Ala Leu Ser Arg Pro Ser 
65                  70      


<210>  85
<211>  2805
<212>  DNA
<213>  Homosapiens

<400>  85
ggcttcagct tcttagcctg ggaaatgtga gggctagtgc agcgctgagc ccagacccct     60

cacacagcgc taccggcaac ttgcttaacc tagaggtggg gggtgacgtc cctgtcggcc    120

ccgtcacctg gggccccagc acctctcctt ggctttgcag acgatgttcc acaggagccc    180

gtgcccacgc tgtggaacga gccggccgag ctgccgtcgg gagaaggccc cgtggagagc    240

accagccccg gccgggagcc cgtggacacc ggtcccccag cccccaccgt cgcgccagga    300

cccgaggaca gcaccgcgca ggagcggctg gaccagggcg gcgggtcgct ggggcccggc    360

gctatcgcgg ccatcgtgat cgccgccctg ctggccacct gcgtggtgct ggcgctcgtg    420

gtcgtcgcgc tgagaaagtt ttctgcctcc tgaagcgaat aaaggggccg cgcccggccg    480

cggcgcgact cggctgcact cctcacgcgc ctgtatgtcc gcgcgtgcgt gtccgcgcat    540

gcaggtgtgc cagagcgtga gcgcgcgcag gcgagcgctc agggcggggg tgcgcgcggg    600

gccgagggtg ggtgccgtgc acgcgcgcgg gtccggaggc gcgcccgaat tccccgcagg    660

ggcgccgggg cgtgcgtgag cgcacagcat gtccgagccc gcctgcgtgt ggcgtgcacc    720

tgagcgcgcg cagggccgcg cggctcggcg tccccgtgca ccacggctgg agtgcctcag    780

gagcgcgccg catgtgcgtg cccggtgcgc gtgcgccggg gccgccaggg catcggagcg    840

ggtgtgcggc cagcggtctt agcccgtccg ggggcaccgt cacggtcagg gccacgccac    900

gggcggcccc ttctcccggc gccgcctcct ctgcctgggc gcgggccgag gccctcgccg    960

cgctccccgg ggcctgcctc ccatcccgct ccgctggggt tcagagcgtt ccgtgaggag   1020

gtaagcgcta gggcaggaga ggccgacaga gaccccgggg cccgccgctc cttgaggccg   1080

gggttgggga gggcaggggc cgtcggctct cccagccaga ggccgcgtgg ttttggggga   1140

cgtcttgact ctgagtcctg cagccagggc cccatccgcg ggctcagacc agcagcccca   1200

agcccccctc tgcccaggga gcctcaggag caggatgagt cgagagtcga cgccggacac   1260

ggcccgcccc tgcttcctac tctcaccccc aggcctggct gggggccggc agcccccacg   1320

cccacggttg gtttgttcag ggagagaaaa cggctttccc agctctactc acctcacttc   1380

accctcagag agtcggggcg gagtgagggt gaggagcctg gtccagggtc cccacctcgg   1440

aagcatttag agatgtaaac tttgatcctt tgatcattta acctgctcag cacagcagga   1500

agtgggaact tggtccctac cccagtcccc agggcctttg gagggaaggg ttggacagtt   1560

tggaggccag cagacccctt ggggacagct taatgtatct gaagattcct gagtgggaat   1620

gttgctggag ggcaagctgc ttctcttttt taaaaattca ttttctctag cagctgtttt   1680

ggcccctttg gtgtccctga gctccccatg gcactgtttc ctgccgtgac tttctcctcc   1740

tggacactgg agcccaggtg gtgcccgcgc acctctcaca cactggggga tagggtcaag   1800

gcctcatcca agtctgttaa cagcttccca ctcaaccagt ctccccaaaa tacactgtga   1860

gttcaatgat tctgcttata aaggagtgct atgaaactga cctattttcc taattggtta   1920

actgacttca tctcacataa ccttgagtaa ccaaagcctt catcagagcg gacgatccaa   1980

cccaacatgc tgtttcccat cctcaaaagg cacggggacc aatggccacc caactccttc   2040

ccaaccctcc cctccaggga cgagagatgg ccccctcttt ccctttcccc actctgcaag   2100

cactccccca ccaacgggtg catcacagcc cctcactggg accagggggc ctccctctcc   2160

ggtggaacca gtgtcacatg cctgtgcatc tctgtgattc tcagagggtc tgaggtccga   2220

gcaccctgct gtggcctgtg ggaagacgct acaaagtccc actggatcta aaccagaggc   2280

ctgttctggc gagcagggaa actgtgtcct ggcagagatc gtggtcctgg gcacacagga   2340

cccctcagca cactgaggtg gagctggggc gaggggaggg ggtgcgctct gggtaactga   2400

aggtgtgaag ggcccagggc ctgtttctgg gcagtgcagg aagtcccagc cccatgcctg   2460

tggtgagatc ccctgtaggg ccccccccac catggacact tcggggcctc tacggtcttc   2520

caaagctgtg tcctcatttc cactgcagca gaggggcgtc cccagctccg tcaaacagcc   2580

ctttctgttt ctggagtcct acaagtggag gcccaaatcc gttcccatgt tgaggcaagg   2640

ccctggctgt tccttcctct ctggaaaccg ccttgaactc ttcctttggg acatgcctcc   2700

tcgaccagcc ttgaaggggt gctcctctct cactacctgg aaccaaacac ccccttcctt   2760

tgtgtacaag ggcaataaag agtagacctt catcttcttt atttt                   2805


<210>  86
<211>  71
<212>  PRT
<213>  Homosapiens

<400>  86

Met Phe His Arg Ser Pro Cys Pro Arg Cys Gly Thr Ser Arg Pro Ser 
1               5                   10                  15      


Cys Arg Arg Glu Lys Ala Pro Trp Arg Ala Pro Ala Pro Ala Gly Ser 
            20                  25                  30          


Pro Trp Thr Pro Val Pro Gln Pro Pro Pro Ser Arg Gln Asp Pro Arg 
        35                  40                  45              


Thr Ala Pro Arg Arg Ser Gly Trp Thr Arg Ala Ala Gly Arg Trp Gly 
    50                  55                  60                  


Pro Ala Leu Ser Arg Pro Ser 
65                  70      


<210>  87
<211>  660
<212>  DNA
<213>  Homosapiens

<400>  87
tgcacgcgcg cgggtccgga ggcgcgcccg aattccccgc aggggcgccg gggcgtgcgt     60

gagcgcacag catgtccgag cccgcctgcg tgtggcgtgc acctgagcgc gcgcagggcc    120

gcgcggctcg gcgtccccgt gcaccacggc tggagtgcct caggagcgcg ccgcatgtgc    180

gtgcccggtg cgcgtgcgcc ggggccgcca gggcatcgga gcgggtgtgc ggccagcggt    240

cttagcccgt ccgggggcac cgtcacggtc agggccacgc cacgggcggc cccttctccc    300

ggcgccgcct cctctgcctg ggcgcgggcc gaggccctcg ccgcgctccc cggggcctgc    360

ctcccatccc gctccgctgg ggttcagagc gttccgtgag gagcagaggg gcgtccccag    420

ctccgtcaaa cagccctttc tgtttctgga gtcctacaag tggaggccca aatccgttcc    480

catgttgagg caaggccctg gctgttcctt cctctctgga aaccgccttg aactcttcct    540

ttgggacatg cctcctcgac cagccttgaa ggggtgctcc tctctcacta cctggaacca    600

aacaccccct tcctttgtgt acaagggcaa taaagagtag accttcatct tctttatttt    660


<210>  88
<211>  74
<212>  PRT
<213>  Homosapiens

<400>  88

Met Cys Val Pro Gly Ala Arg Ala Pro Gly Pro Pro Gly His Arg Ser 
1               5                   10                  15      


Gly Cys Ala Ala Ser Gly Leu Ser Pro Ser Gly Gly Thr Val Thr Val 
            20                  25                  30          


Arg Ala Thr Pro Arg Ala Ala Pro Ser Pro Gly Ala Ala Ser Ser Ala 
        35                  40                  45              


Trp Ala Arg Ala Glu Ala Leu Ala Ala Leu Pro Gly Ala Cys Leu Pro 
    50                  55                  60                  


Ser Arg Ser Ala Gly Val Gln Ser Val Pro 
65                  70                  


<210>  89
<211>  1474
<212>  DNA
<213>  Homosapiens

<400>  89
gacagaggga gactctgtct caaaaagaaa acacaagttc agctgcctta tggagaagct     60

gctaaccctg accatgtgaa ccctgtcctg accaccccaa accacaccca gggccatatc    120

ccaggtacaa aaagttcctt ctgaagttta aactaaggcc ccctcacagc ctttatgcat    180

gtatttcttc ccagaactcc tggctatgtt aataacgttt tctatggaaa caaatcctcc    240

tcttcctcag acgagccctt ctccagttgc tgtgggagtt ttcctattct aggcagggct    300

cagctgcggg cttggtggga gtgtgcaggt gggtagtgcg gtggtgggga tgtgcccgtg    360

cctcttgtcc ctcagactgc ccccaggtcc agtgcgtgca cccatacgtg gctcagcagc    420

cagacgagct gacgctggag ctcgccgaca tcctcaacat cctggacaag actgacgacg    480

ggtggatctt tggcgagcgt ctgcacgacc aggagagagg ctggttcccc agctccatga    540

ctgaggagat cttgaatccc aagatccggt cccagaacct caaggaatgt ttccgtgtcc    600

acaagatgga tgaccctcag cgcagccaga acaaggaccg caggaagctg ggcagccgga    660

atcggcaatg acccccaccc agggggccag cgggagcagg gcctgcatga gaccccgaca    720

gaaggtgggg gggggggggc tctgggaagc acaggccagc acctccccag gtggcaggat    780

ctggcttggg gtgcccggcc ctcatccctg cccacgcagt gagtgctcat gtgtcttggc    840

cccttgctcg caaactggat aaagggtgcc caagcctctc ctgatgcatt tgtaaacaag    900

aaggtttcag cagtattaca ccacctccct catgcctccg agggggtgga agggggtggg    960

cacactccag ggccccccat gcccctggcc cccagggact ggaagaggct cccaacccag   1020

agtgtccctg tgggaggcag gcagaaggtg acaattgaca cgatttcctg cacgcgtcct   1080

cctctacctt ggaagcagtt agaatctacc aggcacagat gaggccgccc ttgcctgacg   1140

gagcttgatg agcagccctt ggtctccggt tccaggactg agagcccagc tgcctctgcc   1200

cacccttccc caggcctctg ccagcctctg gctgcacggt caggccctgc cccatggcag   1260

gcctgccaga gcttggctgg ggacccctcc cgcctctggc tccctgatgg gctggatgta   1320

acttgtgtct tctagcccct taaggagccc aggtgtttta aggaatgaat tggtcactgc   1380

atcttgtatc gattatggtt ctgagaaaag caaatatcac ttttggctgc attaaaagaa   1440

gcatcatata taaaataaag aagatgaagg tcta                               1474


<210>  90
<211>  97
<212>  PRT
<213>  Homosapiens

<400>  90

Met Cys Leu Gly Pro Leu Leu Ala Asn Trp Ile Lys Gly Ala Gln Ala 
1               5                   10                  15      


Ser Pro Asp Ala Phe Val Asn Lys Lys Val Ser Ala Val Leu His His 
            20                  25                  30          


Leu Pro His Ala Ser Glu Gly Val Glu Gly Gly Gly His Thr Pro Gly 
        35                  40                  45              


Pro Pro Met Pro Leu Ala Pro Arg Asp Trp Lys Arg Leu Pro Thr Gln 
    50                  55                  60                  


Ser Val Pro Val Gly Gly Arg Gln Lys Val Thr Ile Asp Thr Ile Ser 
65                  70                  75                  80  


Cys Thr Arg Pro Pro Leu Pro Trp Lys Gln Leu Glu Ser Thr Arg His 
                85                  90                  95      


Arg 
    


<210>  91
<211>  1696
<212>  DNA
<213>  Homosapiens

<400>  91
aaccgcttgt gcaaaggccc caagactgca agaacatcct gaagagggta gaagagaggt     60

ctgagcggga gtgcactgct ttggatgctc acaaggagct ggaaatggtg gtgaaggcat    120

gcaacgaggg cgtcaggaaa atgagccgca cggaacagat gatcagcatt cagaagaaga    180

tggagttcaa gatcaagtcg gtgcccatca tctcccactc ccgctggctg ctgaagcagg    240

gtgagctgca gcagatgtca ggccccaaga cctcccggac cctgaggacc aagaagctct    300

tccacgaaat ttacctcttc ctgttcaacg acctgctggt gatctgccgg cagattccag    360

gagacaagta ccaggtattt gactcagctc cgcggggact gctgcgtgtg gaggagctgg    420

aggaccaggg ccagacgctg gccaacgtgt tcatcctgcg gctgctggag aacgcagatg    480

accgggaggc cacctacatg ctaaaggcgt cctctcagag tgagatgaag cgttggatga    540

cctcactggc ccccaacagg aggaccaagt ttgtttcgtt cacatcccgg ctgctggact    600

gcccccaggt ccagtgcgtg cacccatacg tggctcagca gccagacgag ctgacgctgg    660

agctcgccga catcctcaac atcctggaca agactgacga cgggtggatc tttggcgagc    720

gtctgcacga ccaggagaga ggctggttcc ccagctccat gactgaggag atcttgaatc    780

ccaagatccg gtcccagaac ctcaaggaat gtttccgtgt ccacaagatg gatgaccctc    840

agcgcagcca gaacaaggac cgcaggaagc tgggcagccg gaatcggcaa tgacccccac    900

ccagggggcc agcgggagca gggcctgcat gagaccccga cagaaggtgg gggggggggg    960

gctctgggaa gcacaggcca gcacctcccc aggtggcagg atctggcttg gggtgcccgg   1020

ccctcatccc tgcccacgca gtgagtgctc atgtgtcttg gccccttgct cgcaaactgg   1080

ataaagggtg cccaagcctc tcctgatgca tttgtaaaca agaaggtttc agcagtatta   1140

caccacctcc ctcatgcctc cgagggggtg gaagggggtg ggcacactcc agggcccccc   1200

atgcccctgg cccccaggga ctggaagagg ctcccaaccc agagtgtccc tgtgggaggc   1260

aggcagaagg tgacaattga cacgatttcc tgcacgcgtc ctcctctacc ttggaagcag   1320

ttagaatcta ccaggcacag atgaggccgc ccttgcctga cggagcttga tgagcagccc   1380

ttggtctccg gttccaggac tgagagccca gctgcctctg cccacccttc cccaggcctc   1440

tgccagcctc tggctgcacg gtcaggccct gccccatggc aggcctgcca gagcttggct   1500

ggggacccct cccgcctctg gctccctgat gggctggatg taacttgtgt cttctagccc   1560

cttaaggagc ccaggtgttt taaggaatga attggtcact gcatcttgta tcgattatgg   1620

ttctgagaaa agcaaatatc acttttggct gcattaaaag aagcatcata tataaaataa   1680

agaagatgaa ggtcta                                                   1696


<210>  92
<211>  262
<212>  PRT
<213>  Homosapiens

<400>  92

Met Val Val Lys Ala Cys Asn Glu Gly Val Arg Lys Met Ser Arg Thr 
1               5                   10                  15      


Glu Gln Met Ile Ser Ile Gln Lys Lys Met Glu Phe Lys Ile Lys Ser 
            20                  25                  30          


Val Pro Ile Ile Ser His Ser Arg Trp Leu Leu Lys Gln Gly Glu Leu 
        35                  40                  45              


Gln Gln Met Ser Gly Pro Lys Thr Ser Arg Thr Leu Arg Thr Lys Lys 
    50                  55                  60                  


Leu Phe His Glu Ile Tyr Leu Phe Leu Phe Asn Asp Leu Leu Val Ile 
65                  70                  75                  80  


Cys Arg Gln Ile Pro Gly Asp Lys Tyr Gln Val Phe Asp Ser Ala Pro 
                85                  90                  95      


Arg Gly Leu Leu Arg Val Glu Glu Leu Glu Asp Gln Gly Gln Thr Leu 
            100                 105                 110         


Ala Asn Val Phe Ile Leu Arg Leu Leu Glu Asn Ala Asp Asp Arg Glu 
        115                 120                 125             


Ala Thr Tyr Met Leu Lys Ala Ser Ser Gln Ser Glu Met Lys Arg Trp 
    130                 135                 140                 


Met Thr Ser Leu Ala Pro Asn Arg Arg Thr Lys Phe Val Ser Phe Thr 
145                 150                 155                 160 


Ser Arg Leu Leu Asp Cys Pro Gln Val Gln Cys Val His Pro Tyr Val 
                165                 170                 175     


Ala Gln Gln Pro Asp Glu Leu Thr Leu Glu Leu Ala Asp Ile Leu Asn 
            180                 185                 190         


Ile Leu Asp Lys Thr Asp Asp Gly Trp Ile Phe Gly Glu Arg Leu His 
        195                 200                 205             


Asp Gln Glu Arg Gly Trp Phe Pro Ser Ser Met Thr Glu Glu Ile Leu 
    210                 215                 220                 


Asn Pro Lys Ile Arg Ser Gln Asn Leu Lys Glu Cys Phe Arg Val His 
225                 230                 235                 240 


Lys Met Asp Asp Pro Gln Arg Ser Gln Asn Lys Asp Arg Arg Lys Leu 
                245                 250                 255     


Gly Ser Arg Asn Arg Gln 
            260         


<210>  93
<211>  3176
<212>  DNA
<213>  Homosapiens

<400>  93
caggacagga cgaagttttt ggctgtgggc tctctgggac agagtggagc gcctgtggat     60

ttagccgggg acacaccatc ctgctcgcag gtgcctggac aggacagggg acgagggagg    120

aacactctct gaggaagccc aactcctatg agctcctctc tggcagcact caaaccagtg    180

aagcttggga aagtcattga cctccagtcg ttctgctgag aaacatctgg ctctatttcc    240

atggagacca gggaatctga agatttggaa aagacccgga ggaaatcagc aagtgatcaa    300

tggaacactg ataatgaacc agccaaggtg aaacctgagt tactcccaga aaaagaggag    360

acttctcaag ctgaccagga tatccaagac aaagagcctc attgccacat cccaattaag    420

agaaattcca tcttcaatcg ctccataaga cgcaaaagca aagccaaggc cagagacaac    480

cccgaacgga acgccagctg cctggcagat tcacaggaca atggaaaatc tgtaaatgag    540

cccctgacct tgaatatccc ctggagcaga atgcctcctt gcagaacagc aatgcagaca    600

gacccaggag cccaggaaat gagtgagtcg tcctccaccc cgggaaatgg ggccacgccc    660

gaggagtggc cggccctggc cgacagcccc accacgctca ccgaggccct gcggatgatc    720

caccccattc ccgccgactc ctggagaaac ctcattgaac aaatagggct cctgtatcag    780

gaataccgag ataaatcgac tctccaagaa atcgaaacca ggaggcaaca ggatgcagaa    840

atagaagaca ataccaatgg gtccccggcc agtgaggaca ccccggagga ggaagaagaa    900

gaggaggagg aggaggagcc ggccagccca ccagagagga agactctgcc ccagatctgc    960

ctgctcagta acccccactc aaggttcaac ctctggcagg atcttcccga gatccggagc   1020

agcggggtgc ttgagatcct acagcccgag gagattaagc tgcaggaggc catgttcgag   1080

ctggtcactt ccgaggcgtc ctactacaag agtctgaacc tgctcgtgtc ccacttcatg   1140

gagaacgagc ggataaggaa gatcctgcac ccgtccgagg cgcacatcct cttctccaac   1200

gtcctggacg tgctggctgt cagtgagcgg ttcctcctgg agctggagca ccggatggag   1260

gagaacatcg tcatctctga cgtgtgtgac attgtgtacc gttatgcggc cgaccacttc   1320

tctgtctaca tcacctacgt cagcaatcag acctaccagg agcggaccta taagcagctg   1380

ctccaggaga aggcagcttt ccgggagctg atcgcgcagc tagagctcga ccccaagtgc   1440

agggggctgc ccttctcctc cttcctcatc ctgcctttcc agaggatcac acgcctcaag   1500

ctgttggtcc agaacatcct gaagagggta gaagagaggt ctgagcggga gtgcactgct   1560

ttggatgctc acaaggagct ggaaatggtg gtgaaggcat gcaacgaggg cgtcaggaaa   1620

atgagccgca cggaacagat gatcagcatt cagaagaaga tggagttcaa gatcaagtcg   1680

gtgcccatca tctcccactc ccgctggctg ctgaagcagg gtgagctgca gcagatgtca   1740

ggccccaaga cctcccggac cctgaggacc aagaagctct tccacgaaat ttacctcttc   1800

ctgttcaacg acctgctggt gatctgccgg cagattccag gagacaagta ccaggtattt   1860

gactcagctc cgcggggact gctgcgtgtg gaggagctgg aggaccaggg ccagacgctg   1920

gccaacgtgt tcatcctgcg gctgctggag aacgcagatg accgggaggc cacctacatg   1980

ctaaaggcgt cctctcagag tgagatgaag cgttggatga cctcactggc ccccaacagg   2040

aggaccaagt ttgtttcgtt cacatcccgg ctgctggact gcccccaggt ccagtgcgtg   2100

cacccatacg tggctcagca gccagacgag ctgacgctgg agctcgccga catcctcaac   2160

atcctggaca agactgacga cgggtggatc tttggcgagc gtctgcacga ccaggagaga   2220

ggctggttcc ccagctccat gactgaggag atcttgaatc ccaagatccg gtcccagaac   2280

ctcaaggaat gtttccgtgt ccacaagatg gatgaccctc agcgcagcca gaacaaggac   2340

cgcaggaagc tgggcagccg gaatcggcaa tgacccccac ccagggggcc agcgggagca   2400

gggcctgcat gagaccccga cagaaggtgg gggggggggg gctctgggaa gcacaggcca   2460

gcacctcccc aggtggcagg atctggcttg gggtgcccgg ccctcatccc tgcccacgca   2520

gtgagtgctc atgtgtcttg gccccttgct cgcaaactgg ataaagggtg cccaagcctc   2580

tcctgatgca tttgtaaaca agaaggtttc agcagtatta caccacctcc ctcatgcctc   2640

cgagggggtg gaagggggtg ggcacactcc agggcccccc atgcccctgg cccccaggga   2700

ctggaagagg ctcccaaccc agagtgtccc tgtgggaggc aggcagaagg tgacaattga   2760

cacgatttcc tgcacgcgtc ctcctctacc ttggaagcag ttagaatcta ccaggcacag   2820

atgaggccgc ccttgcctga cggagcttga tgagcagccc ttggtctccg gttccaggac   2880

tgagagccca gctgcctctg cccacccttc cccaggcctc tgccagcctc tggctgcacg   2940

gtcaggccct gccccatggc aggcctgcca gagcttggct ggggacccct cccgcctctg   3000

gctccctgat gggctggatg taacttgtgt cttctagccc cttaaggagc ccaggtgttt   3060

taaggaatga attggtcact gcatcttgta tcgattatgg ttctgagaaa agcaaatatc   3120

acttttggct gcattaaaag aagcatcata tataaaataa agaagatgaa ggtcta       3176


<210>  94
<211>  710
<212>  PRT
<213>  Homosapiens

<400>  94

Met Glu Thr Arg Glu Ser Glu Asp Leu Glu Lys Thr Arg Arg Lys Ser 
1               5                   10                  15      


Ala Ser Asp Gln Trp Asn Thr Asp Asn Glu Pro Ala Lys Val Lys Pro 
            20                  25                  30          


Glu Leu Leu Pro Glu Lys Glu Glu Thr Ser Gln Ala Asp Gln Asp Ile 
        35                  40                  45              


Gln Asp Lys Glu Pro His Cys His Ile Pro Ile Lys Arg Asn Ser Ile 
    50                  55                  60                  


Phe Asn Arg Ser Ile Arg Arg Lys Ser Lys Ala Lys Ala Arg Asp Asn 
65                  70                  75                  80  


Pro Glu Arg Asn Ala Ser Cys Leu Ala Asp Ser Gln Asp Asn Gly Lys 
                85                  90                  95      


Ser Val Asn Glu Pro Leu Thr Leu Asn Ile Pro Trp Ser Arg Met Pro 
            100                 105                 110         


Pro Cys Arg Thr Ala Met Gln Thr Asp Pro Gly Ala Gln Glu Met Ser 
        115                 120                 125             


Glu Ser Ser Ser Thr Pro Gly Asn Gly Ala Thr Pro Glu Glu Trp Pro 
    130                 135                 140                 


Ala Leu Ala Asp Ser Pro Thr Thr Leu Thr Glu Ala Leu Arg Met Ile 
145                 150                 155                 160 


His Pro Ile Pro Ala Asp Ser Trp Arg Asn Leu Ile Glu Gln Ile Gly 
                165                 170                 175     


Leu Leu Tyr Gln Glu Tyr Arg Asp Lys Ser Thr Leu Gln Glu Ile Glu 
            180                 185                 190         


Thr Arg Arg Gln Gln Asp Ala Glu Ile Glu Asp Asn Thr Asn Gly Ser 
        195                 200                 205             


Pro Ala Ser Glu Asp Thr Pro Glu Glu Glu Glu Glu Glu Glu Glu Glu 
    210                 215                 220                 


Glu Glu Pro Ala Ser Pro Pro Glu Arg Lys Thr Leu Pro Gln Ile Cys 
225                 230                 235                 240 


Leu Leu Ser Asn Pro His Ser Arg Phe Asn Leu Trp Gln Asp Leu Pro 
                245                 250                 255     


Glu Ile Arg Ser Ser Gly Val Leu Glu Ile Leu Gln Pro Glu Glu Ile 
            260                 265                 270         


Lys Leu Gln Glu Ala Met Phe Glu Leu Val Thr Ser Glu Ala Ser Tyr 
        275                 280                 285             


Tyr Lys Ser Leu Asn Leu Leu Val Ser His Phe Met Glu Asn Glu Arg 
    290                 295                 300                 


Ile Arg Lys Ile Leu His Pro Ser Glu Ala His Ile Leu Phe Ser Asn 
305                 310                 315                 320 


Val Leu Asp Val Leu Ala Val Ser Glu Arg Phe Leu Leu Glu Leu Glu 
                325                 330                 335     


His Arg Met Glu Glu Asn Ile Val Ile Ser Asp Val Cys Asp Ile Val 
            340                 345                 350         


Tyr Arg Tyr Ala Ala Asp His Phe Ser Val Tyr Ile Thr Tyr Val Ser 
        355                 360                 365             


Asn Gln Thr Tyr Gln Glu Arg Thr Tyr Lys Gln Leu Leu Gln Glu Lys 
    370                 375                 380                 


Ala Ala Phe Arg Glu Leu Ile Ala Gln Leu Glu Leu Asp Pro Lys Cys 
385                 390                 395                 400 


Arg Gly Leu Pro Phe Ser Ser Phe Leu Ile Leu Pro Phe Gln Arg Ile 
                405                 410                 415     


Thr Arg Leu Lys Leu Leu Val Gln Asn Ile Leu Lys Arg Val Glu Glu 
            420                 425                 430         


Arg Ser Glu Arg Glu Cys Thr Ala Leu Asp Ala His Lys Glu Leu Glu 
        435                 440                 445             


Met Val Val Lys Ala Cys Asn Glu Gly Val Arg Lys Met Ser Arg Thr 
    450                 455                 460                 


Glu Gln Met Ile Ser Ile Gln Lys Lys Met Glu Phe Lys Ile Lys Ser 
465                 470                 475                 480 


Val Pro Ile Ile Ser His Ser Arg Trp Leu Leu Lys Gln Gly Glu Leu 
                485                 490                 495     


Gln Gln Met Ser Gly Pro Lys Thr Ser Arg Thr Leu Arg Thr Lys Lys 
            500                 505                 510         


Leu Phe His Glu Ile Tyr Leu Phe Leu Phe Asn Asp Leu Leu Val Ile 
        515                 520                 525             


Cys Arg Gln Ile Pro Gly Asp Lys Tyr Gln Val Phe Asp Ser Ala Pro 
    530                 535                 540                 


Arg Gly Leu Leu Arg Val Glu Glu Leu Glu Asp Gln Gly Gln Thr Leu 
545                 550                 555                 560 


Ala Asn Val Phe Ile Leu Arg Leu Leu Glu Asn Ala Asp Asp Arg Glu 
                565                 570                 575     


Ala Thr Tyr Met Leu Lys Ala Ser Ser Gln Ser Glu Met Lys Arg Trp 
            580                 585                 590         


Met Thr Ser Leu Ala Pro Asn Arg Arg Thr Lys Phe Val Ser Phe Thr 
        595                 600                 605             


Ser Arg Leu Leu Asp Cys Pro Gln Val Gln Cys Val His Pro Tyr Val 
    610                 615                 620                 


Ala Gln Gln Pro Asp Glu Leu Thr Leu Glu Leu Ala Asp Ile Leu Asn 
625                 630                 635                 640 


Ile Leu Asp Lys Thr Asp Asp Gly Trp Ile Phe Gly Glu Arg Leu His 
                645                 650                 655     


Asp Gln Glu Arg Gly Trp Phe Pro Ser Ser Met Thr Glu Glu Ile Leu 
            660                 665                 670         


Asn Pro Lys Ile Arg Ser Gln Asn Leu Lys Glu Cys Phe Arg Val His 
        675                 680                 685             


Lys Met Asp Asp Pro Gln Arg Ser Gln Asn Lys Asp Arg Arg Lys Leu 
    690                 695                 700                 


Gly Ser Arg Asn Arg Gln 
705                 710 


<210>  95
<211>  451
<212>  DNA
<213>  Homosapiens

<400>  95
ctgagttact cccagaaaaa gaggagactt ctcaagctga ccaggatatc caagacaaag     60

agcctcattg ccacatccca attaagagaa attccatctt caatcgctcc ataagacgca    120

aaagcaaagc caaggccaga gacaaccccg aacggaacgc cagctgcctg gcagattcac    180

aggacaatgg aaaatctgta aatgagcccc tgaccttgaa tatcccctgg agcagaatgc    240

ctccttgcag aacagcaatg cagacagacc caggagccca ggaaatgagg taagagatgg    300

cagatcatga ggaatgctgg tctgggaaag atgcatcaga ggtcattgct gcaaagactt    360

gacagggtta cgagggtgtc atgttaaaaa aaataataat aacttttggt tgcccgtgct    420

aaaaaaataa ataaataaaa actccataat t                                   451


<210>  96
<211>  38
<212>  PRT
<213>  Homosapiens

<400>  96

Met Leu Val Trp Glu Arg Cys Ile Arg Gly His Cys Cys Lys Asp Leu 
1               5                   10                  15      


Thr Gly Leu Arg Gly Cys His Val Lys Lys Asn Asn Asn Asn Phe Trp 
            20                  25                  30          


Leu Pro Val Leu Lys Lys 
        35              


<210>  97
<211>  641
<212>  DNA
<213>  Homosapiens

<400>  97
actggcgtcg tgggtgtggg gcctgggcag tcacagggcc ctgttcttag aaggtgcccc     60

ggcttgcttt aatgctgtgt tgttgtcctt ttgaaagcct tactatttta acaaggggcc    120

ctgcattttt atattgcaca gggccctgca attatgcagc cattcctgct tttgatctca    180

cttaccccac agccataatg gaagagcgcc tggaaggagt ccttatcctg attcccagat    240

ggtgaaactg agtgccagga ggggcagtgc tgaagccgag accagacagg atccctcggg    300

tggaatccag ggctgctgtt tctcttgggg gctcctcctc agtgaatgga tgggtggcac    360

ctgcgagcag gatggtgtgt ccccggctaa atccacaggc gctccactct gtcccagaga    420

gcccacagcc aaaaacttcg tcctgtcctg gaaaagcttc actgccttcc aacagagcct    480

tcctgcatgc cgaggttgaa gaggtgtccg ctgagtgctc tgtcttctgg gaattttggc    540

tgtttcctgc aacctatcat cagatgccac acttatgaga ccctcatcct tctgctcact    600

ctcttccatt gtttcactca ttaaaaatat atattttaag c                        641


<210>  98
<211>  86
<212>  PRT
<213>  Homosapiens

<400>  98

Met Val Lys Leu Ser Ala Arg Arg Gly Ser Ala Glu Ala Glu Thr Arg 
1               5                   10                  15      


Gln Asp Pro Ser Gly Gly Ile Gln Gly Cys Cys Phe Ser Trp Gly Leu 
            20                  25                  30          


Leu Leu Ser Glu Trp Met Gly Gly Thr Cys Glu Gln Asp Gly Val Ser 
        35                  40                  45              


Pro Ala Lys Ser Thr Gly Ala Pro Leu Cys Pro Arg Glu Pro Thr Ala 
    50                  55                  60                  


Lys Asn Phe Val Leu Ser Trp Lys Ser Phe Thr Ala Phe Gln Gln Ser 
65                  70                  75                  80  


Leu Pro Ala Cys Arg Gly 
                85      


<210>  99
<211>  665
<212>  DNA
<213>  Homosapiens

<400>  99
gcaattatgc agccattcct gcttttgatc tcacttaccc cacagccata atggaagagc     60

gcctggaagg agtccttatc ctgattccca gatggtgaaa ctgagtgcca ggaggggcag    120

tgctgaagcc gagaccagac aggatccctc gggtggaatc cagggctgct gtttctcttg    180

ggggctcctc ctcagtgaat ggatgggtgg taatctcctt tcctacctgt cctagcggta    240

gcctctgttc cttctcttgt tttatctcat tttatttttt taaaaaatac caaaaccatt    300

ctctcacctg ccagagagga gctcatagga gttgggcttc ctcagagagt gttcctccct    360

cgtcccctgt cctgtccagg cacctgcgag caggatggtg tgtccccggc taaatccaca    420

ggcgctccac tctgtcccag agagcccaca gccaaaaact tcgtcctgtc ctggaaaagc    480

ttcactgcct tccaacagag ccttcctgca tgccgaggtt gaagaggtgt ccgctgagtg    540

ctctgtcttc tgggaatttt ggctgtttcc tgcaacctat catcagatgc cacacttatg    600

agaccctcat ccttctgctc actctcttcc attgtttcac tcattaaaaa tatatatttt    660

aagca                                                                665


<210>  100
<211>  68
<212>  PRT
<213>  Homosapiens

<400>  100

Met Val Cys Pro Arg Leu Asn Pro Gln Ala Leu His Ser Val Pro Glu 
1               5                   10                  15      


Ser Pro Gln Pro Lys Thr Ser Ser Cys Pro Gly Lys Ala Ser Leu Pro 
            20                  25                  30          


Ser Asn Arg Ala Phe Leu His Ala Glu Val Glu Glu Val Ser Ala Glu 
        35                  40                  45              


Cys Ser Val Phe Trp Glu Phe Trp Leu Phe Pro Ala Thr Tyr His Gln 
    50                  55                  60                  


Met Pro His Leu 
65              


<210>  101
<211>  1143
<212>  DNA
<213>  Homosapiens

<400>  101
atggcgtccc ttcctgtcct gcagaaggag agcgtgttcc agtcgggagc ccatgcctac     60

agaatccctg ccctgctcta cctgcctggg cagcagtccc tgctggcctt cgcggaacag    120

cgggcaagca agaaggatga gcacgcagag ctgattgtcc tgcgcagagg agactacgac    180

gcacccaccc accaggttca gtggcaagct caggaggtgg tggcccaggc ccggctggat    240

ggccaccggt ccatgaaccc atgccccttg tatgacgcgc agacggggac cctcttcctc    300

ttcttcattg ccatccctgg gcaagtcacg gagcaacagc agctgcagac cagggccaat    360

gtgacgcggc tgtgccaagt caccagcact gaccacggga ggacctggag ctcccccaga    420

gacctcactg atgcggccat cggcccagcc taccgggagt ggtccacctt tgcagtgggc    480

ccggggcatt gtttgcagct tcacgacagg gcccggagcc tggtggtgcc cgcctacgcc    540

taccggaaac ttcaccccat ccaaaggccg atcccctctg ccttctgctt cctcagccat    600

gaccatgggc gcacgtgggc gcgagggcac tttgtggccc aggacaccct ggagtgccag    660

gtggccgaag tcgagactgg ggagcagagg gtggtgaccc tcaacgcgag aagccacctc    720

cgagccaggg tccaggccca gagcaccaat gacgggcttg atttccagga gtctcagctg    780

gtgaagaagc tggtggagcc gccgccccag ggctgccagg ggagcgtcat cagcttcccc    840

agcccccgct cggggcctgg ctccccagcc cagtggctgc tctacactca ccccacacac    900

tcctggcaga gggccgacct gggtgcctac ctcaacccgc gacctccagc ccctgaggcc    960

tggtcagagc cggtactgct ggccaagggc agctgtgcct actcagacct ccagagcatg   1020

ggcaccggcc ctgatgggtc ccccttgttt gggtgtctgt acgaagccaa tgattacgag   1080

gagattgtct ttctcatgtt caccctgaag caagccttcc cagctgagta cctgcctcag   1140

tga                                                                 1143


<210>  102
<211>  380
<212>  PRT
<213>  Homosapiens

<400>  102

Met Ala Ser Leu Pro Val Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Pro Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Ala Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Ile Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Gln Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Cys Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln 
    370                 375                 380 


<210>  103
<211>  4911
<212>  DNA
<213>  Homosapiens

<400>  103
gggcaggccg tagtcccagt tgagaagctg tgcccccttg ggtgttttgg aggttcaggg     60

tgggtgctga aaagccctga gggagagcag aaggctcggg ggcctgtcta gggcatggca    120

tcccacgtgg gtgtcagcac ggccgcagaa gaaccacttc tctggcccac ccatgcctgc    180

taggccatgc ttcttcagaa gtggccacaa ctctcctgac gtctccagag ccggtcattc    240

cacccagggg gacttcagct gccactggac acttcaattg tacgctgcga ccagttgcca    300

ggaaggagag ggctggcaag agagccgcgg cagccgtggc agggtgtagg ggacggtgga    360

cggccagggc ccccccctct ctctctttct ctctctctct cttgcttggt ttctgtaatg    420

aggaagttct ccgcagctca gtttcctttc cctcactgag cgcctgaaac aggaagtcag    480

tcagttaagc tggtggcagc agccgaggcc accaagaggc aacgggcggc aggttgcagt    540

ggaggggcct ccgctcccct cggtggtgtg tgggtcctgg gggtgcctgc cggcccggcc    600

gaggaggccc acgcccacca tggtcccctg ctggaaccat ggcaacatca cccgctccaa    660

ggcggaggag ctgctttcca ggacaggcaa ggacgggagc ttcctcgtgc gtgccagcga    720

gtccatctcc cgggcatacg cgctctgcgt gctgtatcgg aattgcgttt acacttacag    780

aattctgccc aatgaagatg ataaattcac tgttcaggca tccgaaggcg tctccatgag    840

gttcttcacc aagctggacc agctcatcga gttttacaag aaggaaaaca tggggctggt    900

gacccatctg caataccctg tgccgctgga ggaagaggac acaggcgacg accctgagga    960

ggacacagta gaaagtgtcg tgtctccacc cgagctgccc ccaagaaaca tcccgctgac   1020

tgccagctcc tgtgaggcca aggaggttcc tttttcaaac gagaatcccc gagcgaccga   1080

gaccagccgg ccgagcctct ccgagacatt gttccagcga ctgcaaagca tggacaccag   1140

tgggcttcca gaagagcatc ttaaggccat ccaagattat ttaagcactc agctcgccca   1200

ggactctgaa tttgtgaaga cagggtccag cagtcttcct cacctgaaga aactgaccac   1260

actgctctgc aaggagctct atggaagaga gaaggcttct gccagctcct gcagcagatg   1320

aagaacaagc actcagagca gccggagccc gacatgatca ccatcttcat cggcacctgg   1380

aacatgggta acgccccccc tcccaagaag atcacgtcct ggtttctctc caaggggcag   1440

ggaaagacgc gggacgactc tgcggactac atcccccatg acatttacgt gatcggcacc   1500

caagaggacc ccctgagtga gaaggagtgg ctggagatcc tcaaacactc cctgcaagaa   1560

atcaccagtg tgacttttaa aacagtcgcc atccacacgc tctggaacat ccgcatcgtg   1620

gtgctggcca agcctgagca cgagaaccgg atcagccaca tctgtactga caacgtgaag   1680

acaggcattg caaacacact ggggaacaag ggagccgtgg gggtgtcgtt catgttcaat   1740

ggaacctcct tagggttcgt caacagccac ttgacttcag gaagtgaaaa gaaactcagg   1800

cgaaaccaaa actatatgaa cattctccgg ttcctggccc tgggcgacaa gaagctgagt   1860

ccctttaaca tcactcaccg cttcacgcac ctcttctggt ttggggatct taactaccgt   1920

gtggatctgc ctacctggga ggcagaaacc atcatccaga aaatcaagca gcagcagtac   1980

gcagacctcc tgtcccacga ccagctgctc acagagagga gggagcagaa ggtcttccta   2040

cacttcgagg aggaagaaat cacgtttgcc ccaacctacc gttttgagag actgactcgg   2100

gacaaatacg cctacaccaa gcagaaagcg acagggatga agtacaactt gccttcctgg   2160

tgtgaccgag tcctctggaa gtcttatccc ctggtgcacg tggtgtgtca gtcttatggc   2220

agtaccagcg acatcatgac gagtgaccac agccctgtct ttgccacatt tgaggcagga   2280

gtcacttccc agtttgtctc caagaacggt cccgggactg ttgacagcca aggacagatt   2340

gagtttctca ggtgctatgc cacattgaag accaagtccc agaccaaatt ctacctggag   2400

ttccactcga gctgcttgga gagttttgtc aagagtcagg aaggagaaaa tgaagaagga   2460

agtgaggggg agctggtggt gaagtttggt gagactcttc caaagctgaa gcccattatc   2520

tctgaccctg agtacctgct agaccagcac atcctcatca gcatcaagtc ctctgacagc   2580

gacgaatcct atggcgaggg ctgcattgcc cttcggttag aggccacaga aacgcagctg   2640

cccatctaca cgcctctcac ccaccatggg gagttgacag gccacttcca gggggagatc   2700

aagctgcaga cctctcaggg caagacgagg gagaagctct atgactttgt gaagacggag   2760

cgtgatgaat ccagtgggcc aaagaccctg aagagcctca ccagccacga ccccatgaag   2820

cagtgggaag tcactagcag ggcccctccg tgcagtggct ccagcatcac tgaaatcatc   2880

aaccccaact acatgggagt ggggcccttt gggccaccaa tgcccctgca cgtgaagcag   2940

accttgtccc ctgaccagca gcccacagcc tggagctacg accagccgcc caaggactcc   3000

ccgctggggc cctgcagggg agaaagtcct ccgacacctc ccggccagcc gcccatatca   3060

cccaagaagt ttttaccctc aacagcaaac cggggtctcc ctcccaggac acaggagtca   3120

aggcccagtg acctggggaa gaacgcaggg gacacgctgc ctcaggagga cctgccgctg   3180

acgaagcccg agatgtttga gaaccccctg tatgggtccc tgagttcctt ccctaagcct   3240

gctcccagga aggaccagga atcccccaaa atgccgcgga aggaaccccc gccctgcccg   3300

gaacccggca tcttgtcgcc cagcatcgtg ctcaccaaag cccaggaggc tgatcgcggc   3360

gaggggcccg gcaagcaggt gcccgcgccc cggctgcgct ccttcacgtg ctcatcctct   3420

gccgagggca gggcggccgg cggggacaag agccaaggga agcccaagac cccggtcagc   3480

tcccaggccc cggtgccggc caagaggccc atcaagcctt ccagatcgga aatcaaccag   3540

cagaccccgc ccaccccgac gccgcggccg ccgctgccag tcaagagccc ggcggtgctg   3600

cacctccagc actccaaggg ccgcgactac cgcgacaaca ccgagctccc gcatcacggc   3660

aagcaccggc cggaggaggg gccaccaggg cctctaggca ggactgccat gcagtgaagc   3720

cctcagtgag ctgccactga gtcgggagcc cagaggaacg gcgtgaagcc actggaccct   3780

ctcccgggac ctcctgctgg ctcctcctgc ccagcttcct atgcaaggct ttgtgttttc   3840

aggaaagggc ctagcttctg tgtggcccac agagttcact gcctgtgaga cttagcacca   3900

agtgctgagg ctggaagaaa aacgcacacc agacgggcaa caaacagtct gggtccccag   3960

ctcgctcttg gtacttggga ccccagtgcc tcgttgaggg cgccattctg aagaaaggaa   4020

ctgcagcgcc gatttgaggg tggagatata gataataata atattaataa taataatggc   4080

cacatggatc gaacactcat gatgtgccaa gtgctgtgct aagtgcttta cgaacattcg   4140

tcatatcagg atgacctcga gagctgaggc tctagccacc taaaaccacg tgcccaaacc   4200

caccagttta aaacggtgtg tgttcggagg ggtgaaagca ttaagaagcc cagtgccctc   4260

ctggagtgag acaagggctc ggccttaagg agctgaagag tctgggtagc ttgtttaggg   4320

tacaagaagc ctgttctgtc cagcttcagt gacacaagct gctttagcta aagtcccgcg   4380

ggttccggca tggctaggct gagagcaggg atctacctgg cttctcagtt ctttggttgg   4440

aaggagcagg aaatcagctc ctattctcca gtggagagat ctggcctcag cttgggctag   4500

agatgccaag gcctgtgcca ggttccctgt gccctcctcg aggtgggcag ccatcaccag   4560

ccacagttaa gccaagcccc ccaacatgta ttccatcgtg ctggtagaag agtctttgct   4620

gttgctcccg aaagccgtgc tctccagcct ggctgccagg gagggtgggc ctcttggttc   4680

caggctcttg aaatagtgca gccttttctt cctatctctg tggctttcag ctctgcttcc   4740

ttggttatta ggagaataga tgggtgatgt ctttccttat gttgcttttt caacatagca   4800

gaattaatgt agggagctaa atccagtggt gtgtgtgaat gcagaaggga atgcacccca   4860

cattcccatg atggaagtct gcgtaaccaa taaattgtgc ctttctcact c            4911


<210>  104
<211>  799
<212>  PRT
<213>  Homosapiens

<400>  104

Met Lys Asn Lys His Ser Glu Gln Pro Glu Pro Asp Met Ile Thr Ile 
1               5                   10                  15      


Phe Ile Gly Thr Trp Asn Met Gly Asn Ala Pro Pro Pro Lys Lys Ile 
            20                  25                  30          


Thr Ser Trp Phe Leu Ser Lys Gly Gln Gly Lys Thr Arg Asp Asp Ser 
        35                  40                  45              


Ala Asp Tyr Ile Pro His Asp Ile Tyr Val Ile Gly Thr Gln Glu Asp 
    50                  55                  60                  


Pro Leu Ser Glu Lys Glu Trp Leu Glu Ile Leu Lys His Ser Leu Gln 
65                  70                  75                  80  


Glu Ile Thr Ser Val Thr Phe Lys Thr Val Ala Ile His Thr Leu Trp 
                85                  90                  95      


Asn Ile Arg Ile Val Val Leu Ala Lys Pro Glu His Glu Asn Arg Ile 
            100                 105                 110         


Ser His Ile Cys Thr Asp Asn Val Lys Thr Gly Ile Ala Asn Thr Leu 
        115                 120                 125             


Gly Asn Lys Gly Ala Val Gly Val Ser Phe Met Phe Asn Gly Thr Ser 
    130                 135                 140                 


Leu Gly Phe Val Asn Ser His Leu Thr Ser Gly Ser Glu Lys Lys Leu 
145                 150                 155                 160 


Arg Arg Asn Gln Asn Tyr Met Asn Ile Leu Arg Phe Leu Ala Leu Gly 
                165                 170                 175     


Asp Lys Lys Leu Ser Pro Phe Asn Ile Thr His Arg Phe Thr His Leu 
            180                 185                 190         


Phe Trp Phe Gly Asp Leu Asn Tyr Arg Val Asp Leu Pro Thr Trp Glu 
        195                 200                 205             


Ala Glu Thr Ile Ile Gln Lys Ile Lys Gln Gln Gln Tyr Ala Asp Leu 
    210                 215                 220                 


Leu Ser His Asp Gln Leu Leu Thr Glu Arg Arg Glu Gln Lys Val Phe 
225                 230                 235                 240 


Leu His Phe Glu Glu Glu Glu Ile Thr Phe Ala Pro Thr Tyr Arg Phe 
                245                 250                 255     


Glu Arg Leu Thr Arg Asp Lys Tyr Ala Tyr Thr Lys Gln Lys Ala Thr 
            260                 265                 270         


Gly Met Lys Tyr Asn Leu Pro Ser Trp Cys Asp Arg Val Leu Trp Lys 
        275                 280                 285             


Ser Tyr Pro Leu Val His Val Val Cys Gln Ser Tyr Gly Ser Thr Ser 
    290                 295                 300                 


Asp Ile Met Thr Ser Asp His Ser Pro Val Phe Ala Thr Phe Glu Ala 
305                 310                 315                 320 


Gly Val Thr Ser Gln Phe Val Ser Lys Asn Gly Pro Gly Thr Val Asp 
                325                 330                 335     


Ser Gln Gly Gln Ile Glu Phe Leu Arg Cys Tyr Ala Thr Leu Lys Thr 
            340                 345                 350         


Lys Ser Gln Thr Lys Phe Tyr Leu Glu Phe His Ser Ser Cys Leu Glu 
        355                 360                 365             


Ser Phe Val Lys Ser Gln Glu Gly Glu Asn Glu Glu Gly Ser Glu Gly 
    370                 375                 380                 


Glu Leu Val Val Lys Phe Gly Glu Thr Leu Pro Lys Leu Lys Pro Ile 
385                 390                 395                 400 


Ile Ser Asp Pro Glu Tyr Leu Leu Asp Gln His Ile Leu Ile Ser Ile 
                405                 410                 415     


Lys Ser Ser Asp Ser Asp Glu Ser Tyr Gly Glu Gly Cys Ile Ala Leu 
            420                 425                 430         


Arg Leu Glu Ala Thr Glu Thr Gln Leu Pro Ile Tyr Thr Pro Leu Thr 
        435                 440                 445             


His His Gly Glu Leu Thr Gly His Phe Gln Gly Glu Ile Lys Leu Gln 
    450                 455                 460                 


Thr Ser Gln Gly Lys Thr Arg Glu Lys Leu Tyr Asp Phe Val Lys Thr 
465                 470                 475                 480 


Glu Arg Asp Glu Ser Ser Gly Pro Lys Thr Leu Lys Ser Leu Thr Ser 
                485                 490                 495     


His Asp Pro Met Lys Gln Trp Glu Val Thr Ser Arg Ala Pro Pro Cys 
            500                 505                 510         


Ser Gly Ser Ser Ile Thr Glu Ile Ile Asn Pro Asn Tyr Met Gly Val 
        515                 520                 525             


Gly Pro Phe Gly Pro Pro Met Pro Leu His Val Lys Gln Thr Leu Ser 
    530                 535                 540                 


Pro Asp Gln Gln Pro Thr Ala Trp Ser Tyr Asp Gln Pro Pro Lys Asp 
545                 550                 555                 560 


Ser Pro Leu Gly Pro Cys Arg Gly Glu Ser Pro Pro Thr Pro Pro Gly 
                565                 570                 575     


Gln Pro Pro Ile Ser Pro Lys Lys Phe Leu Pro Ser Thr Ala Asn Arg 
            580                 585                 590         


Gly Leu Pro Pro Arg Thr Gln Glu Ser Arg Pro Ser Asp Leu Gly Lys 
        595                 600                 605             


Asn Ala Gly Asp Thr Leu Pro Gln Glu Asp Leu Pro Leu Thr Lys Pro 
    610                 615                 620                 


Glu Met Phe Glu Asn Pro Leu Tyr Gly Ser Leu Ser Ser Phe Pro Lys 
625                 630                 635                 640 


Pro Ala Pro Arg Lys Asp Gln Glu Ser Pro Lys Met Pro Arg Lys Glu 
                645                 650                 655     


Pro Pro Pro Cys Pro Glu Pro Gly Ile Leu Ser Pro Ser Ile Val Leu 
            660                 665                 670         


Thr Lys Ala Gln Glu Ala Asp Arg Gly Glu Gly Pro Gly Lys Gln Val 
        675                 680                 685             


Pro Ala Pro Arg Leu Arg Ser Phe Thr Cys Ser Ser Ser Ala Glu Gly 
    690                 695                 700                 


Arg Ala Ala Gly Gly Asp Lys Ser Gln Gly Lys Pro Lys Thr Pro Val 
705                 710                 715                 720 


Ser Ser Gln Ala Pro Val Pro Ala Lys Arg Pro Ile Lys Pro Ser Arg 
                725                 730                 735     


Ser Glu Ile Asn Gln Gln Thr Pro Pro Thr Pro Thr Pro Arg Pro Pro 
            740                 745                 750         


Leu Pro Val Lys Ser Pro Ala Val Leu His Leu Gln His Ser Lys Gly 
        755                 760                 765             


Arg Asp Tyr Arg Asp Asn Thr Glu Leu Pro His His Gly Lys His Arg 
    770                 775                 780                 


Pro Glu Glu Gly Pro Pro Gly Pro Leu Gly Arg Thr Ala Met Gln 
785                 790                 795                 


<210>  105
<211>  5230
<212>  DNA
<213>  Homosapiens

<400>  105
gggcaggccg tagtcccagt tgagaagctg tgcccccttg ggtgttttgg aggttcaggg     60

tgggtgctga aaagccctga gggagagcag aaggctcggg ggcctgtcta gggcatggca    120

tcccacgtgg gtgtcagcac ggccgcagaa gaaccacttc tctggcccac ccatgcctgc    180

taggccatgc ttcttcagaa gtggccacaa ctctcctgac gtctccagag ccggtcattc    240

cacccagggg gacttcagct gccactggac acttcaattg tacgctgcga ccagttgcca    300

ggaaggagag ggctggcaag agagccgcgg cagccgtggc agggtgtagg ggacggtgga    360

cggccagggc ccccccctct ctctctttct ctctctctct cttgcttggt ttctgtaatg    420

aggaagttct ccgcagctca gtttcctttc cctcactgag cgcctgaaac aggaagtcag    480

tcagttaagc tggtggcagc agccgaggcc accaagaggc aacgggcggc aggttgcagt    540

ggaggggcct ccgctcccct cggtggtgtg tgggtcctgg gggtgcctgc cggcccggcc    600

gaggaggccc acgcccacca tggtcccctg ctggaaccat ggcaacatca cccgctccaa    660

ggcggaggag ctgctttcca ggacaggcaa ggacgggagc ttcctcgtgc gtgccagcga    720

gtccatctcc cgggcatacg cgctctgcgt gctgtatcgg aattgcgttt acacttacag    780

aattctgccc aatgaagatg ataaattcac tgttcaggca tccgaaggcg tctccatgag    840

gttcttcacc aagctggacc agctcatcga gttttacaag aaggaaaaca tggggctggt    900

gacccatctg caataccctg tgccgctgga ggaagaggac acaggcgacg accctgagga    960

ggacacagta gaaagtgtcg tgtctccacc cgagctgccc ccaagaaaca tcccgctgac   1020

tgccagctcc tgtgaggcca aggaggttcc tttttcaaac gagaatcccc gagcgaccga   1080

gaccagccgg ccgagcctct ccgagacatt gttccagcga ctgcaaagca tggacaccag   1140

tgggcttcca gaagagcatc ttaaggccat ccaagattat ttaagcactc agctcgccca   1200

ggactctgaa tttgtgaaga cagggtccag cagtcttcct cacctgaaga aactgaccac   1260

actgctctgc aaggagctct atggaagaga gaaggcttct gccagctcct gcagcagatg   1320

aagaacaagc actcagagca gccggagccc gacatgatca ccatcttcat cggcacctgg   1380

aacatgggta acgccccccc tcccaagaag atcacgtcct ggtttctctc caaggggcag   1440

ggaaagacgc gggacgactc tgcggactac atcccccatg acatttacgt gatcggcacc   1500

caagaggacc ccctgagtga gaaggagtgg ctggagatcc tcaaacactc cctgcaagaa   1560

atcaccagtg tgacttttaa aacagtcgcc atccacacgc tctggaacat ccgcatcgtg   1620

gtgctggcca agcctgagca cgagaaccgg atcagccaca tctgtactga caacgtgaag   1680

acaggcattg caaacacact ggggaacaag ggagccgtgg gggtgtcgtt catgttcaat   1740

ggaacctcct tagggttcgt caacagccac ttgacttcag gaagtgaaaa gaaactcagg   1800

cgaaaccaaa actatatgaa cattctccgg ttcctggccc tgggcgacaa gaagctgagt   1860

ccctttaaca tcactcaccg cttcacgcac ctcttctggt ttggggatct taactaccgt   1920

gtggatctgc ctacctggga ggcagaaacc atcatccaga aaatcaagca gcagcagtac   1980

gcagacctcc tgtcccacga ccagctgctc acagagagga gggagcagaa ggtcttccta   2040

cacttcgagg aggaagaaat cacgtttgcc ccaacctacc gttttgagag actgactcgg   2100

gacaaatacg cctacaccaa gcagaaagcg acagggatga agtacaactt gccttcctgg   2160

tgtgaccgag tcctctggaa gtcttatccc ctggtgcacg tggtgtgtca gtcttatggc   2220

agtaccagcg acatcatgac gagtgaccac agccctgtct ttgccacatt tgaggcagga   2280

gtcacttccc agtttgtctc caagaacggt cccgggactg ttgacagcca aggacagatt   2340

gagtttctca ggtgctatgc cacattgaag accaagtccc agaccaaatt ctacctggag   2400

ttccactcga gctgcttgga gagttttgtc aagagtcagg aaggagaaaa tgaagaagga   2460

agtgaggggg agctggtggt gaagtttggt gagactcttc caaagctgaa gcccattatc   2520

tctgaccctg agtacctgct agaccagcac atcctcatca gcatcaagtc ctctgacagc   2580

gacgaatcct atggcgaggg ctgcattgcc cttcggttag aggccacaga aacgcagctg   2640

cccatctaca cgcctctcac ccaccatggg gagttgacag gccacttcca gggggagatc   2700

aagctgcaga cctctcaggg caagacgagg gagaagctct atgactttgt gaagacggag   2760

cgtgatgaat ccagtgggcc aaagaccctg aagagcctca ccagccacga ccccatgaag   2820

cagtgggaag tcactagcag ggcccctccg tgcagtggct ccagcatcac tgaaatcatc   2880

aaccccaact acatgggagt ggggcccttt gggccaccaa tgcccctgca cgtgaagcag   2940

accttgtccc ctgaccagca gcccacagcc tggagctacg accagccgcc caaggactcc   3000

ccgctggggc cctgcagggg agaaagtcct ccgacacctc ccggccagcc gcccatatca   3060

cccaagaagt ttttaccctc aacagcaaac cggggtctcc ctcccaggac acaggagtca   3120

aggcccagtg acctggggaa gaacgcaggg gacacgctgc ctcaggagga cctgccgctg   3180

acgaagcccg agatgtttga gaaccccctg tatgggtccc tgagttcctt ccctaagcct   3240

gctcccagga aggaccagga atcccccaaa atgccgcgga aggaaccccc gccctgcccg   3300

gaacccggca tcttgtcgcc cagcatcgtg ctcaccaaag cccaggaggc tgatcgcggc   3360

gaggggcccg gcaagcaggt gcccgcgccc cggctgcgct ccttcacgtg ctcatcctct   3420

gccgagggca gggcggccgg cggggacaag agccaaggga agcccaagac cccggtcagc   3480

tcccaggccc cggtgccggc caagaggccc atcaagcctt ccagatcgga aatcaaccag   3540

cagaccccgc ccaccccgac gccgcggccg ccgctgccag tcaagagccc ggcggtgctg   3600

cacctccagc actccaaggg ccgcgactac cgcgacaaca ccgagctccc gcatcacggc   3660

aagcaccggc cggaggaggg gccaccaggg cctctaggca ggactgccat gcagtgaagc   3720

cctcagtgag ctgccactga gtcgggagcc cagaggaacg gcgtgaagcc actggaccct   3780

ctcccgggac ctcctgctgg ctcctcctgc ccagcttcct atgcaaggct ttgtgttttc   3840

aggaaagggc ctagcttctg tgtggcccac agagttcact gcctgtgaga cttagcacca   3900

agtgctgagg ctggaagaaa aacgcacacc agacgggcaa caaacagtct gggtccccag   3960

ctcgctcttg gtacttggga ccccagtgcc tcgttgaggg cgccattctg aagaaaggaa   4020

ctgcagcgcc gatttgaggg tggagatata gataataata atattaataa taataatggc   4080

cacatggatc gaacactcat gatgtgccaa gtgctgtgct aagtgcttta cgaacattcg   4140

tcatatcagg atgacctcga gagctgaggc tctagccacc taaaaccacg tgcccaaacc   4200

caccagttta aaacggtgtg tgttcggagg ggtgaaagca ttaagaagcc cagtgccctc   4260

ctggagtgag acaagggctc ggccttaagg agctgaagag tctgggtagc ttgtttaggg   4320

tacaagaagc ctgttctgtc cagcttcagt gacacaagct gctttagcta aagtcccgcg   4380

ggttccggca tggctaggct gagagcaggg atctacctgg cttctcagtt ctttggttgg   4440

aaggagcagg aaatcagctc ctattctcca gtggagagat ctggcctcag cttgggctag   4500

agatgccaag gcctgtgcca ggttccctgt gccctcctcg aggtgggcag ccatcaccag   4560

ccacagttaa gccaagcccc ccaacatgta ttccatcgtg ctggtagaag agtctttgct   4620

gttgctcccg aaagccgtgc tctccagcct ggctgccagg gagggtgggc ctcttggttc   4680

caggctcttg aaatagtgca gccttttctt cctatctctg tggctttcag ctctgcttcc   4740

ttggttatta ggagaataga tgggtgatgt ctttccttat gttgcttttt caacatagca   4800

gaattaatgt agggagctaa atccagtggt gtgtgtgaat gcagaaggga atgcacccca   4860

cattcccatg atggaagtct gcgtaaccaa taaattgtgc ctttctcact cagctgtgtg   4920

tgtggcgttt ttcctgacat tcggagccat agatatcctt ctagatggca gggcctgcac   4980

agggcacaac tgaggcagtt aagggttcat ggtggtgatg gatggtgttg ccctgaccag   5040

atgggacacc atagagccag tttgaagctg gtcctggact aggaacagga gtaaaccgca   5100

ccccttcctt ccttccaccc acacatcttc ctggcactcc aagcaccctg cggccaccca   5160

gaggccacga gcatcccctc caaacctgct gtcctgcagc ccacaagttc ctcccagctt   5220

ttataagttt                                                          5230


<210>  106
<211>  799
<212>  PRT
<213>  Homosapiens

<400>  106

Met Lys Asn Lys His Ser Glu Gln Pro Glu Pro Asp Met Ile Thr Ile 
1               5                   10                  15      


Phe Ile Gly Thr Trp Asn Met Gly Asn Ala Pro Pro Pro Lys Lys Ile 
            20                  25                  30          


Thr Ser Trp Phe Leu Ser Lys Gly Gln Gly Lys Thr Arg Asp Asp Ser 
        35                  40                  45              


Ala Asp Tyr Ile Pro His Asp Ile Tyr Val Ile Gly Thr Gln Glu Asp 
    50                  55                  60                  


Pro Leu Ser Glu Lys Glu Trp Leu Glu Ile Leu Lys His Ser Leu Gln 
65                  70                  75                  80  


Glu Ile Thr Ser Val Thr Phe Lys Thr Val Ala Ile His Thr Leu Trp 
                85                  90                  95      


Asn Ile Arg Ile Val Val Leu Ala Lys Pro Glu His Glu Asn Arg Ile 
            100                 105                 110         


Ser His Ile Cys Thr Asp Asn Val Lys Thr Gly Ile Ala Asn Thr Leu 
        115                 120                 125             


Gly Asn Lys Gly Ala Val Gly Val Ser Phe Met Phe Asn Gly Thr Ser 
    130                 135                 140                 


Leu Gly Phe Val Asn Ser His Leu Thr Ser Gly Ser Glu Lys Lys Leu 
145                 150                 155                 160 


Arg Arg Asn Gln Asn Tyr Met Asn Ile Leu Arg Phe Leu Ala Leu Gly 
                165                 170                 175     


Asp Lys Lys Leu Ser Pro Phe Asn Ile Thr His Arg Phe Thr His Leu 
            180                 185                 190         


Phe Trp Phe Gly Asp Leu Asn Tyr Arg Val Asp Leu Pro Thr Trp Glu 
        195                 200                 205             


Ala Glu Thr Ile Ile Gln Lys Ile Lys Gln Gln Gln Tyr Ala Asp Leu 
    210                 215                 220                 


Leu Ser His Asp Gln Leu Leu Thr Glu Arg Arg Glu Gln Lys Val Phe 
225                 230                 235                 240 


Leu His Phe Glu Glu Glu Glu Ile Thr Phe Ala Pro Thr Tyr Arg Phe 
                245                 250                 255     


Glu Arg Leu Thr Arg Asp Lys Tyr Ala Tyr Thr Lys Gln Lys Ala Thr 
            260                 265                 270         


Gly Met Lys Tyr Asn Leu Pro Ser Trp Cys Asp Arg Val Leu Trp Lys 
        275                 280                 285             


Ser Tyr Pro Leu Val His Val Val Cys Gln Ser Tyr Gly Ser Thr Ser 
    290                 295                 300                 


Asp Ile Met Thr Ser Asp His Ser Pro Val Phe Ala Thr Phe Glu Ala 
305                 310                 315                 320 


Gly Val Thr Ser Gln Phe Val Ser Lys Asn Gly Pro Gly Thr Val Asp 
                325                 330                 335     


Ser Gln Gly Gln Ile Glu Phe Leu Arg Cys Tyr Ala Thr Leu Lys Thr 
            340                 345                 350         


Lys Ser Gln Thr Lys Phe Tyr Leu Glu Phe His Ser Ser Cys Leu Glu 
        355                 360                 365             


Ser Phe Val Lys Ser Gln Glu Gly Glu Asn Glu Glu Gly Ser Glu Gly 
    370                 375                 380                 


Glu Leu Val Val Lys Phe Gly Glu Thr Leu Pro Lys Leu Lys Pro Ile 
385                 390                 395                 400 


Ile Ser Asp Pro Glu Tyr Leu Leu Asp Gln His Ile Leu Ile Ser Ile 
                405                 410                 415     


Lys Ser Ser Asp Ser Asp Glu Ser Tyr Gly Glu Gly Cys Ile Ala Leu 
            420                 425                 430         


Arg Leu Glu Ala Thr Glu Thr Gln Leu Pro Ile Tyr Thr Pro Leu Thr 
        435                 440                 445             


His His Gly Glu Leu Thr Gly His Phe Gln Gly Glu Ile Lys Leu Gln 
    450                 455                 460                 


Thr Ser Gln Gly Lys Thr Arg Glu Lys Leu Tyr Asp Phe Val Lys Thr 
465                 470                 475                 480 


Glu Arg Asp Glu Ser Ser Gly Pro Lys Thr Leu Lys Ser Leu Thr Ser 
                485                 490                 495     


His Asp Pro Met Lys Gln Trp Glu Val Thr Ser Arg Ala Pro Pro Cys 
            500                 505                 510         


Ser Gly Ser Ser Ile Thr Glu Ile Ile Asn Pro Asn Tyr Met Gly Val 
        515                 520                 525             


Gly Pro Phe Gly Pro Pro Met Pro Leu His Val Lys Gln Thr Leu Ser 
    530                 535                 540                 


Pro Asp Gln Gln Pro Thr Ala Trp Ser Tyr Asp Gln Pro Pro Lys Asp 
545                 550                 555                 560 


Ser Pro Leu Gly Pro Cys Arg Gly Glu Ser Pro Pro Thr Pro Pro Gly 
                565                 570                 575     


Gln Pro Pro Ile Ser Pro Lys Lys Phe Leu Pro Ser Thr Ala Asn Arg 
            580                 585                 590         


Gly Leu Pro Pro Arg Thr Gln Glu Ser Arg Pro Ser Asp Leu Gly Lys 
        595                 600                 605             


Asn Ala Gly Asp Thr Leu Pro Gln Glu Asp Leu Pro Leu Thr Lys Pro 
    610                 615                 620                 


Glu Met Phe Glu Asn Pro Leu Tyr Gly Ser Leu Ser Ser Phe Pro Lys 
625                 630                 635                 640 


Pro Ala Pro Arg Lys Asp Gln Glu Ser Pro Lys Met Pro Arg Lys Glu 
                645                 650                 655     


Pro Pro Pro Cys Pro Glu Pro Gly Ile Leu Ser Pro Ser Ile Val Leu 
            660                 665                 670         


Thr Lys Ala Gln Glu Ala Asp Arg Gly Glu Gly Pro Gly Lys Gln Val 
        675                 680                 685             


Pro Ala Pro Arg Leu Arg Ser Phe Thr Cys Ser Ser Ser Ala Glu Gly 
    690                 695                 700                 


Arg Ala Ala Gly Gly Asp Lys Ser Gln Gly Lys Pro Lys Thr Pro Val 
705                 710                 715                 720 


Ser Ser Gln Ala Pro Val Pro Ala Lys Arg Pro Ile Lys Pro Ser Arg 
                725                 730                 735     


Ser Glu Ile Asn Gln Gln Thr Pro Pro Thr Pro Thr Pro Arg Pro Pro 
            740                 745                 750         


Leu Pro Val Lys Ser Pro Ala Val Leu His Leu Gln His Ser Lys Gly 
        755                 760                 765             


Arg Asp Tyr Arg Asp Asn Thr Glu Leu Pro His His Gly Lys His Arg 
    770                 775                 780                 


Pro Glu Glu Gly Pro Pro Gly Pro Leu Gly Arg Thr Ala Met Gln 
785                 790                 795                 


<210>  107
<211>  467
<212>  DNA
<213>  Homosapiens

<400>  107
aaagggtaga gagtgggtct cgctggggga ggggaggcag ggagaggctg tccagctcac     60

tcgcatttgt ttctttcctt gattctgttt gtcacaggtt tgtccattta atctcctgca    120

agcacccact cttgctctat cttcttggca gccgagaggt taagaaagcc cctccatgtg    180

gcagactcct ttagatcaga tcctttagct gccgggtccc cacctaaatg acccccccca    240

accttttcct ggtgctccct gagtgcagaa gcagtggggg aataagagtg cctcagccca    300

cgattgctgg acgtcaggac tcacctccat cttaagagaa cggtcagctc cgaaattcgg    360

agactttgtg tccagattcc tcaagctgtg tcaggaagtc ttgtcttttc agttaagagg    420

aaaccgggtc ttcctgcatg ggttctaata aagtctttga tctattt                  467


<210>  108
<211>  35
<212>  PRT
<213>  Homosapiens

<400>  108

Met Thr Pro Pro Asn Leu Phe Leu Val Leu Pro Glu Cys Arg Ser Ser 
1               5                   10                  15      


Gly Gly Ile Arg Val Pro Gln Pro Thr Ile Ala Gly Arg Gln Asp Ser 
            20                  25                  30          


Pro Pro Ser 
        35  


<210>  109
<211>  664
<212>  DNA
<213>  Homosapiens

<400>  109
aagagagaag gcttctgcca gctcctgcag cagatgaaga acaagcactc agagcagccg     60

gagcccgaca tgatcaccat cttcatcggc acctggaact gggcctcttg gttccaggct    120

cttgaaatag tgcagccttt tcttcctatc tctgtggctt tcagctctgc ttccttggtt    180

attaggagaa tagatgggtg atgtctttcc ttatgttgct ttttcaacat agcagaatta    240

atgtagggag ctaaatccag tggtgtgtgt gaatgcagaa gggaatgcac cccacattcc    300

catgatggaa gtctgcgtaa ccaataaatt gtgcctttct cactcagctg tgtgtgtggc    360

gtttttcctg acattcggag ccatagatat ccttctagat ggcagggcct gcacagggca    420

caactgaggc agttaagggt tcatggtggt gatggatggt gttgccctga ccagatggga    480

caccatagag ccagtttgaa gctggtcctg gactaggaac aggagtaaac cgcacccctt    540

ccttccttcc acccacacat cttcctggca ctccaagcac cctgcggcca cccagaggcc    600

acgagcatcc cctccaaacc tgctgtcctg cagcccacaa gttcctccca gcttttataa    660

gttt                                                                 664


<210>  110
<211>  55
<212>  PRT
<213>  Homosapiens

<400>  110

Met Lys Asn Lys His Ser Glu Gln Pro Glu Pro Asp Met Ile Thr Ile 
1               5                   10                  15      


Phe Ile Gly Thr Trp Asn Trp Ala Ser Trp Phe Gln Ala Leu Glu Ile 
            20                  25                  30          


Val Gln Pro Phe Leu Pro Ile Ser Val Ala Phe Ser Ser Ala Ser Leu 
        35                  40                  45              


Val Ile Arg Arg Ile Asp Gly 
    50                  55  


<210>  111
<211>  1391
<212>  DNA
<213>  Homosapiens

<400>  111
cagtggctca tgcctgtaat cccagaactt tgggaggccc aggcaggcag atcacctggc     60

gaaactcagt tgcaaaacaa atttataata acaatgagat ataaatgatt taggctcctt    120

ttctttatgg aatcttcttc ctctgggact gacactagac taagtttatc cacagccccg    180

cctttcttcc ttttaacaac tgctgcagag gcaatgcagg gtcagggatg tgtgggacag    240

gcagacctgg gttcaaatcc tgactctccc ttctcatgga gcagttccca ggaccatcac    300

tcgcatgtgt gcacatgcat gcgttcacac atgcacgcac atatgcatgc gtgcacacac    360

acatgcacac acatatgcat aggtacacac atacgcactc acgcatgcac acacacacaa    420

atgcacacga acccacgtgt ggcgcagcgc acctgcatgg cagtcctgcc tagaggccct    480

ggtggcccct cctccggccg gtgcttgccg tgatgcggga gctcggtgtt gtcgcggtag    540

tcgcggccct tggagtgctg gaggtgcagc accgccgggc tcttgactgg cagcggcggc    600

cgcggcgtcg gggtgggcgg ggtctgctgg ttgatttccg atctggaagg cttgatgggc    660

ctcttggccg gcaccggggc ctgggagctg accggggtct tgggcttccc ttggctcttg    720

tccccgccgg ccgccctgcc ctcggcagag gatgagcacg tgaaggagcg cagccggggc    780

gcgggcacct gcttgccggg cccctcgccg cgatcagcct cctgggcttt ggtgagcacg    840

atgctgggcg acaagatgcc gggttccggg cagggcgggg gttccttccg cggcattttg    900

ggggattcct ggtccttcct gggagcaggc ttagggaagg aactcaggga cccatacagg    960

gggttctcaa acatctcggg cttcgtcagc ggcaggtcct cctgaggcag cgtgtcccct   1020

gcgttcttcc ccaggtcact gggcctagag ccagggacag agcagggaag acacatgtcc   1080

aggggagaag acatgggagc atggctgctt aatggctctg ggtctttctt tggggtgata   1140

caaatgtttc tgaactagat agagacatgt aacattgcaa atttactgaa tggcaccaaa   1200

ttgttttgtc ttgttttgtt ttagagacag agtctcgctc tgtcacccag gctggagtgc   1260

agtggtgcgg tcatggctca ctgctgcctc aacctcttgg gctcaagcag tccttcccct   1320

cagcctccca agtagctgag actacttggg agtagctggg agtagctagg agtagctgga   1380

cattgctggg a                                                        1391


<210>  112
<211>  32
<212>  PRT
<213>  Homosapiens

<400>  112

Met Pro Val Ile Pro Glu Leu Trp Glu Ala Gln Ala Gly Arg Ser Pro 
1               5                   10                  15      


Gly Glu Thr Gln Leu Gln Asn Lys Phe Ile Ile Thr Met Arg Tyr Lys 
            20                  25                  30          


<210>  113
<211>  827
<212>  DNA
<213>  Homosapiens

<400>  113
ggaaagggcc tagcttctgt gtggcccaca gagttcactg cctgtgagac ttagcaccaa     60

gtgctgaggc tggaagaaaa acgcacacca gacgggcaac aaacagtctg ggtccccagc    120

tcgctcttgg tacttgggac cccagtgcct cgttgagggc gccattctga agaaaggaac    180

tgcagcgccg atttgagggt ggagatatag ataataataa tattaataat aataatggcc    240

acatggatcg aacactcatg atgtgccaag tgctgtgcta agtgctttac gaacattcgt    300

catatcagga tgacctcgag agctgaggct ctagccacct aaaaccacgt gcccaaaccc    360

accagtttaa aacggtgtgt gttcggaggg gtgaaagcat taagaagccc agtgccctcc    420

tggagtgaga caagggctcg gccttaagga gctgaagagt gggcagccat caccagccac    480

agttaagcca agccccccaa catgtattcc atcgtgctgg tagaagagtc tttgctgttg    540

ctcccgaaag ccgtgctctc cagcctggct gccagggagg gtgggcctct tggttccagg    600

ctcttgaaat agtgcagcct tttcttccta tctctgtggc tttcagctct gcttccttgg    660

ttattaggag aatagatggg tgatgtcttt ccttatgttg ctttttcaac atagcagaat    720

taatgtaggg agctaaatcc agtggtgtgt gtgaatgcag aagggaatgc accccacatt    780

cccatgatgg aagtctgcgt aaccaataaa ttgtgccttt ctcactc                  827


<210>  114
<211>  36
<212>  PRT
<213>  Homosapiens

<400>  114

Met Tyr Ser Ile Val Leu Val Glu Glu Ser Leu Leu Leu Leu Pro Lys 
1               5                   10                  15      


Ala Val Leu Ser Ser Leu Ala Ala Arg Glu Gly Gly Pro Leu Gly Ser 
            20                  25                  30          


Arg Leu Leu Lys 
        35      


<210>  115
<211>  3350
<212>  DNA
<213>  Homosapiens

<400>  115
gggcgggtct tccggccctc tcgaaaatca tttccggcat gagccggaag accgtcccgg     60

atggcctcgg ggactgccag tgtgtggagg tgagctccgg gattgccggc attcccgctt    120

ctgctggttg cttcatgctg caggctgcgg ccgtcagccc tcgctcgcat tggtggcgct    180

gaggtgccgg ggcagcaagt gacatgtcgt cgggcctccg cgccgctgac ttcccccgct    240

ggaagcgcca catctcggag caactgaggc gccgggaccg gctgcagaga caggcgttcg    300

aggagatcat cctgcagtat aacaaattgc tggaaaagtc agatcttcat tcagtgttgg    360

cccagaaact acaggctgaa aagcatgacg taccaaacag gcacgagata agtcccggac    420

atgatggcac atggaatgac aatcagctac aagaaatggc ccaactgagg attaagcacc    480

aagaggaact gactgaatta cacaagaaac gtggggagtt agctcaactg gtgattgacc    540

tgaataacca aatgcagcgg aaggacaggg agatgcagat gaatgaagca aaaattgcag    600

aatgtttgca gactatctct gacctggaga cggagtgcct agacctgcgc actaagcttt    660

gtgaccttga aagagccaac cagaccctga aggatgaata tgatgccctg cagatcactt    720

ttactgcctt ggagggaaaa ctgaggaaaa ctacggaaga gaaccaggag ctggtcacca    780

gatggatggc tgagaaagcc caggaagcca atcggcttaa tgcagagaat gaaaaagact    840

ccaggaggcg gcaagcccgg ctgcagaaag agcttgcaga agcagcaaag gaacctctac    900

cagtcgaaca ggatgatgac attgaggtca ttgtggatga aacttctgat cacacagaag    960

agacctctcc tgtgcgagcc atcagcagag cagccactaa gcgactctcg cagcctgctg   1020

gaggccttct ggattctatc actaatatct ttgggagacg ctctgtctct tccttcccag   1080

tcccccagga caatgtggat actcatcctg gttctggtaa agaagtgagg gtaccagcta   1140

ctgccttgtg tgtcttcgat gcacatgatg gggaagtcaa cgctgtgcag ttcagtccag   1200

gttcccggtt actggccact ggaggcatgg accgcagggt taagctttgg gaagtatttg   1260

gagaaaaatg tgagttcaag ggttccctat ctggcagtaa tgcaggaatt acaagcattg   1320

aatttgatag tgctggatct tacctcttag cagcttcaaa tgattttgca agccgaatct   1380

ggactgtgga tgattatcga ttacggcaca cactcacggg acacagtggg aaagtgctgt   1440

ctgctaagtt cctgctggac aatgcgcgga ttgtctcagg aagtcacgac cggactctca   1500

aactctggga tctacgcagc aaagtctgca taaagacagt gtttgcagga tccagttgca   1560

atgatattgt ctgcacagag caatgtgtaa tgagtggaca ttttgacaag aaaattcgtt   1620

tctgggacat tcgatcagag agcatagttc gagagatgga gctgttggga aagattactg   1680

ccctggactt aaacccagaa aggactgagc tcctgagctg ctcccgtgat gacttgctaa   1740

aagttattga tctccgaaca aatgctatca agcagacatt cagtgcacct gggttcaagt   1800

gcggctctga ctggaccaga gttgtcttca gccctgatgg cagttacgtg gcggcaggct   1860

ctgctgaggg ctctctgtat atctggagtg tgctcacagg gaaagtggaa aaggttcttt   1920

caaagcagca cagctcatcc atcaatgcgg tggcgtggtc gccctctggc tcgcacgttg   1980

tcagtgtgga caaaggatgc aaagctgtgc tgtgggcaca gtactgacgg ggctctcagg   2040

gctgggagga ccccagtgcc ctcctcagaa gaagcacatg ggctcctgca gccctgtcct   2100

ggcaggtgat gtgctgggta tagcatggac ctcccagaga agctcaagct atgtggcact   2160

gtagctttgc cgtgaatggg atttctgaag atttgactga ggtctctctt ggcctggaag   2220

aataacactg aaaaaacctg acgctgcggt cacttagcag aggctcaggt tcttgccttg   2280

ggaaacacta ctagctctga ccttccatac ctcacttggg ggagcacagg gccccgctgg   2340

gcctcctcac caacggcagt gccaaaatca gcccccacat caaggtggtg ttctctgtgc   2400

tttctctcgt ccttccaaag tcggttctgg cctaacgcat gtcccaacac cttgggttca   2460

tttgcccggt gaactcactt taagcattgg attaacggaa actcccgaac tacagacccc   2520

tccctggtgg gttgcatgaa tgtgtctcat tactgctgaa atgtcctcac atctctttca   2580

ctgttcttca gagctttctg gctctctttc ccccacaaaa ttcgacatat ttaaaaatct   2640

ccgtgtggct ttaaaaaatg gttttttgtt tttttgtttt tttgaggtgg gagaggatgt   2700

gtgaaaatct tttccaggga aatgggttcg ctgcagaggt aaggatgtgt tcctgtatcg   2760

atctgcagac acccagaagg tgggtgcaca ctgcatgctt gggggtgcca agggattcga   2820

gacctccaac atacttgtct gaaggtggtg attctggcca tggcccctct gccaagcctg   2880

tgtgcgatgc ccttggtgct ttagtgcaag aagcctaggc tcagaagcac agcagcgcca   2940

tctttccgtt tcaggggttg tgatgaaggc caaggaaaaa catttatctt tactatttta   3000

cctacgtata aagttttagt tcattgggtg tgcgaaacac cctttttatc acttttaaat   3060

ttgcacttta ttttttttct tccatgcttg ttctctggac atttggggat gtgagtgtta   3120

gagctggtga gagaggagtc aggtggcctt cccaccgatg gtcctggcct ccacctgccc   3180

tctcttccct gcctgatcac cgctttccaa tttgcccttc agagaactta agtcaaggag   3240

agttgaaatt cacaggccag ggcacatctt ttatttattt cattatgttg gccaacagaa   3300

cttgattgta aataataata aagaaatctg ttatatactt ttcaaactcc              3350


<210>  116
<211>  607
<212>  PRT
<213>  Homosapiens

<400>  116

Met Ser Ser Gly Leu Arg Ala Ala Asp Phe Pro Arg Trp Lys Arg His 
1               5                   10                  15      


Ile Ser Glu Gln Leu Arg Arg Arg Asp Arg Leu Gln Arg Gln Ala Phe 
            20                  25                  30          


Glu Glu Ile Ile Leu Gln Tyr Asn Lys Leu Leu Glu Lys Ser Asp Leu 
        35                  40                  45              


His Ser Val Leu Ala Gln Lys Leu Gln Ala Glu Lys His Asp Val Pro 
    50                  55                  60                  


Asn Arg His Glu Ile Ser Pro Gly His Asp Gly Thr Trp Asn Asp Asn 
65                  70                  75                  80  


Gln Leu Gln Glu Met Ala Gln Leu Arg Ile Lys His Gln Glu Glu Leu 
                85                  90                  95      


Thr Glu Leu His Lys Lys Arg Gly Glu Leu Ala Gln Leu Val Ile Asp 
            100                 105                 110         


Leu Asn Asn Gln Met Gln Arg Lys Asp Arg Glu Met Gln Met Asn Glu 
        115                 120                 125             


Ala Lys Ile Ala Glu Cys Leu Gln Thr Ile Ser Asp Leu Glu Thr Glu 
    130                 135                 140                 


Cys Leu Asp Leu Arg Thr Lys Leu Cys Asp Leu Glu Arg Ala Asn Gln 
145                 150                 155                 160 


Thr Leu Lys Asp Glu Tyr Asp Ala Leu Gln Ile Thr Phe Thr Ala Leu 
                165                 170                 175     


Glu Gly Lys Leu Arg Lys Thr Thr Glu Glu Asn Gln Glu Leu Val Thr 
            180                 185                 190         


Arg Trp Met Ala Glu Lys Ala Gln Glu Ala Asn Arg Leu Asn Ala Glu 
        195                 200                 205             


Asn Glu Lys Asp Ser Arg Arg Arg Gln Ala Arg Leu Gln Lys Glu Leu 
    210                 215                 220                 


Ala Glu Ala Ala Lys Glu Pro Leu Pro Val Glu Gln Asp Asp Asp Ile 
225                 230                 235                 240 


Glu Val Ile Val Asp Glu Thr Ser Asp His Thr Glu Glu Thr Ser Pro 
                245                 250                 255     


Val Arg Ala Ile Ser Arg Ala Ala Thr Lys Arg Leu Ser Gln Pro Ala 
            260                 265                 270         


Gly Gly Leu Leu Asp Ser Ile Thr Asn Ile Phe Gly Arg Arg Ser Val 
        275                 280                 285             


Ser Ser Phe Pro Val Pro Gln Asp Asn Val Asp Thr His Pro Gly Ser 
    290                 295                 300                 


Gly Lys Glu Val Arg Val Pro Ala Thr Ala Leu Cys Val Phe Asp Ala 
305                 310                 315                 320 


His Asp Gly Glu Val Asn Ala Val Gln Phe Ser Pro Gly Ser Arg Leu 
                325                 330                 335     


Leu Ala Thr Gly Gly Met Asp Arg Arg Val Lys Leu Trp Glu Val Phe 
            340                 345                 350         


Gly Glu Lys Cys Glu Phe Lys Gly Ser Leu Ser Gly Ser Asn Ala Gly 
        355                 360                 365             


Ile Thr Ser Ile Glu Phe Asp Ser Ala Gly Ser Tyr Leu Leu Ala Ala 
    370                 375                 380                 


Ser Asn Asp Phe Ala Ser Arg Ile Trp Thr Val Asp Asp Tyr Arg Leu 
385                 390                 395                 400 


Arg His Thr Leu Thr Gly His Ser Gly Lys Val Leu Ser Ala Lys Phe 
                405                 410                 415     


Leu Leu Asp Asn Ala Arg Ile Val Ser Gly Ser His Asp Arg Thr Leu 
            420                 425                 430         


Lys Leu Trp Asp Leu Arg Ser Lys Val Cys Ile Lys Thr Val Phe Ala 
        435                 440                 445             


Gly Ser Ser Cys Asn Asp Ile Val Cys Thr Glu Gln Cys Val Met Ser 
    450                 455                 460                 


Gly His Phe Asp Lys Lys Ile Arg Phe Trp Asp Ile Arg Ser Glu Ser 
465                 470                 475                 480 


Ile Val Arg Glu Met Glu Leu Leu Gly Lys Ile Thr Ala Leu Asp Leu 
                485                 490                 495     


Asn Pro Glu Arg Thr Glu Leu Leu Ser Cys Ser Arg Asp Asp Leu Leu 
            500                 505                 510         


Lys Val Ile Asp Leu Arg Thr Asn Ala Ile Lys Gln Thr Phe Ser Ala 
        515                 520                 525             


Pro Gly Phe Lys Cys Gly Ser Asp Trp Thr Arg Val Val Phe Ser Pro 
    530                 535                 540                 


Asp Gly Ser Tyr Val Ala Ala Gly Ser Ala Glu Gly Ser Leu Tyr Ile 
545                 550                 555                 560 


Trp Ser Val Leu Thr Gly Lys Val Glu Lys Val Leu Ser Lys Gln His 
                565                 570                 575     


Ser Ser Ser Ile Asn Ala Val Ala Trp Ser Pro Ser Gly Ser His Val 
            580                 585                 590         


Val Ser Val Asp Lys Gly Cys Lys Ala Val Leu Trp Ala Gln Tyr 
        595                 600                 605         


<210>  117
<211>  3623
<212>  DNA
<213>  Homosapiens

<400>  117
gggcgggtct tccggccctc tcgaaaatca tttccggcat gagccggaag accgtcccgg     60

atggcctcgg ggactgccag tgtgtggagg tgagctccgg gattgccggc attcccgctt    120

ctgctggttg cttcatgctg caggctgcgg ccgtcagccc tcgctcgcat tggtggcgct    180

gaggtgccgg ggcagcaagt gacatgtcgt cgggcctccg cgccgctgac ttcccccgct    240

ggaagcgcca catctcggag caactgaggc gccgggaccg gctgcagaga caggcgttcg    300

aggagatcat cctgcagtat aacaaattgc tggaaaagtc agatcttcat tcagtgttgg    360

cccagaaact acaggctgaa aagcatgacg taccaaacag gcacgagata agtcccggac    420

atgatggcac atggaatgac aatcagctac aagaaatggc ccaactgagg attaagcacc    480

aagaggaact gactgaatta cacaagaaac gtggggagtt agctcaactg gtgattgacc    540

tgaataacca aatgcagcgg aaggacaggg agatgcagat gaatgaagca aaaattgcag    600

aatgtttgca gactatctct gacctggaga cggagtgcct agacctgcgc actaagcttt    660

gtgaccttga aagagccaac cagaccctga aggatgaata tgatgccctg cagatcactt    720

ttactgcctt ggagggaaaa ctgaggaaaa ctacggaaga gaaccaggag ctggtcacca    780

gatggatggc tgagaaagcc caggaagcca atcggcttaa tgcagagaat gaaaaagact    840

ccaggaggcg gcaagcccgg ctgcagaaag agcttgcaga agcagcaaag gaacctctac    900

cagtcgaaca ggatgatgac attgaggtca ttgtggatga aacttctgat cacacagaag    960

agacctctcc tgtgcgagcc atcagcagag cagccactaa gcgactctcg cagcctgctg   1020

gaggccttct ggattctatc actaatatct ttgggagacg ctctgtctct tccttcccag   1080

tcccccagga caatgtggat actcatcctg gttctggtaa agaagtgagg gtaccagcta   1140

ctgccttgtg tgtcttcgat gcacatgatg gggaagtcaa cgctgtgcag ttcagtccag   1200

gttcccggtt actggccact ggaggcatgg accgcagggt taagctttgg gaagtatttg   1260

gagaaaaatg tgagttcaag ggttccctat ctggcagtaa tgcaggaatt acaagcattg   1320

aatttgatag tgctggatct tacctcttag cagcttcaaa tgattttgca agccgaatct   1380

ggactgtgga tgattatcga ttacggcaca cactcacggg acacagtggg aaagtgctgt   1440

ctgctaagtt cctgctggac aatgcgcgga ttgtctcagg aagtcacgac cggactctca   1500

aactctggga tctacgcagc aaagtctgtg aggaaattca gtctctctgt ctgtgtatat   1560

gcttagatgt tagcgtggag gtgtgtgttt gcacgtcaga gcctgcattt atgtaatata   1620

gtttgaattt cagatctggc ttcatgttta gaggggcact gaggatagtg atagtttttc   1680

ttgtttaaag cttcatttaa gtgagtaact ctgacaagtc agtggttaga gggtggcagc   1740

attatgtaaa cagccacgtt ggtgcctctg cttgattaat gatgtttgca tttctttcag   1800

gcataaagac agtgtttgca ggatccagtt gcaatgatat tgtctgcaca gagcaatgtg   1860

taatgagtgg acattttgac aagaaaattc gtttctggga cattcgatca gagagcatag   1920

ttcgagagat ggagctgttg ggaaagatta ctgccctgga cttaaaccca gaaaggactg   1980

agctcctgag ctgctcccgt gatgacttgc taaaagttat tgatctccga acaaatgcta   2040

tcaagcagac attcagtgca cctgggttca agtgcggctc tgactggacc agagttgtct   2100

tcagccctga tggcagttac gtggcggcag gctctgctga gggctctctg tatatctgga   2160

gtgtgctcac agggaaagtg gaaaaggttc tttcaaagca gcacagctca tccatcaatg   2220

cggtggcgtg gtcgccctct ggctcgcacg ttgtcagtgt ggacaaagga tgcaaagctg   2280

tgctgtgggc acagtactga cggggctctc agggctggga ggaccccagt gccctcctca   2340

gaagaagcac atgggctcct gcagccctgt cctggcaggt gatgtgctgg gtatagcatg   2400

gacctcccag agaagctcaa gctatgtggc actgtagctt tgccgtgaat gggatttctg   2460

aagatttgac tgaggtctct cttggcctgg aagaataaca ctgaaaaaac ctgacgctgc   2520

ggtcacttag cagaggctca ggttcttgcc ttgggaaaca ctactagctc tgaccttcca   2580

tacctcactt gggggagcac agggccccgc tgggcctcct caccaacggc agtgccaaaa   2640

tcagccccca catcaaggtg gtgttctctg tgctttctct cgtccttcca aagtcggttc   2700

tggcctaacg catgtcccaa caccttgggt tcatttgccc ggtgaactca ctttaagcat   2760

tggattaacg gaaactcccg aactacagac ccctccctgg tgggttgcat gaatgtgtct   2820

cattactgct gaaatgtcct cacatctctt tcactgttct tcagagcttt ctggctctct   2880

ttcccccaca aaattcgaca tatttaaaaa tctccgtgtg gctttaaaaa atggtttttt   2940

gtttttttgt ttttttgagg tgggagagga tgtgtgaaaa tcttttccag ggaaatgggt   3000

tcgctgcaga ggtaaggatg tgttcctgta tcgatctgca gacacccaga aggtgggtgc   3060

acactgcatg cttgggggtg ccaagggatt cgagacctcc aacatacttg tctgaaggtg   3120

gtgattctgg ccatggcccc tctgccaagc ctgtgtgcga tgcccttggt gctttagtgc   3180

aagaagccta ggctcagaag cacagcagcg ccatctttcc gtttcagggg ttgtgatgaa   3240

ggccaaggaa aaacatttat ctttactatt ttacctacgt ataaagtttt agttcattgg   3300

gtgtgcgaaa cacccttttt atcactttta aatttgcact ttattttttt tcttccatgc   3360

ttgttctctg gacatttggg gatgtgagtg ttagagctgg tgagagagga gtcaggtggc   3420

cttcccaccg atggtcctgg cctccacctg ccctctcttc cctgcctgat caccgctttc   3480

caatttgccc ttcagagaac ttaagtcaag gagagttgaa attcacaggc cagggcacat   3540

cttttattta tttcattatg ttggccaaca gaacttgatt gtaaataata ataaagaaat   3600

ctgttatata cttttcaaac tcc                                           3623


<210>  118
<211>  470
<212>  PRT
<213>  Homosapiens

<400>  118

Met Ser Ser Gly Leu Arg Ala Ala Asp Phe Pro Arg Trp Lys Arg His 
1               5                   10                  15      


Ile Ser Glu Gln Leu Arg Arg Arg Asp Arg Leu Gln Arg Gln Ala Phe 
            20                  25                  30          


Glu Glu Ile Ile Leu Gln Tyr Asn Lys Leu Leu Glu Lys Ser Asp Leu 
        35                  40                  45              


His Ser Val Leu Ala Gln Lys Leu Gln Ala Glu Lys His Asp Val Pro 
    50                  55                  60                  


Asn Arg His Glu Ile Ser Pro Gly His Asp Gly Thr Trp Asn Asp Asn 
65                  70                  75                  80  


Gln Leu Gln Glu Met Ala Gln Leu Arg Ile Lys His Gln Glu Glu Leu 
                85                  90                  95      


Thr Glu Leu His Lys Lys Arg Gly Glu Leu Ala Gln Leu Val Ile Asp 
            100                 105                 110         


Leu Asn Asn Gln Met Gln Arg Lys Asp Arg Glu Met Gln Met Asn Glu 
        115                 120                 125             


Ala Lys Ile Ala Glu Cys Leu Gln Thr Ile Ser Asp Leu Glu Thr Glu 
    130                 135                 140                 


Cys Leu Asp Leu Arg Thr Lys Leu Cys Asp Leu Glu Arg Ala Asn Gln 
145                 150                 155                 160 


Thr Leu Lys Asp Glu Tyr Asp Ala Leu Gln Ile Thr Phe Thr Ala Leu 
                165                 170                 175     


Glu Gly Lys Leu Arg Lys Thr Thr Glu Glu Asn Gln Glu Leu Val Thr 
            180                 185                 190         


Arg Trp Met Ala Glu Lys Ala Gln Glu Ala Asn Arg Leu Asn Ala Glu 
        195                 200                 205             


Asn Glu Lys Asp Ser Arg Arg Arg Gln Ala Arg Leu Gln Lys Glu Leu 
    210                 215                 220                 


Ala Glu Ala Ala Lys Glu Pro Leu Pro Val Glu Gln Asp Asp Asp Ile 
225                 230                 235                 240 


Glu Val Ile Val Asp Glu Thr Ser Asp His Thr Glu Glu Thr Ser Pro 
                245                 250                 255     


Val Arg Ala Ile Ser Arg Ala Ala Thr Lys Arg Leu Ser Gln Pro Ala 
            260                 265                 270         


Gly Gly Leu Leu Asp Ser Ile Thr Asn Ile Phe Gly Arg Arg Ser Val 
        275                 280                 285             


Ser Ser Phe Pro Val Pro Gln Asp Asn Val Asp Thr His Pro Gly Ser 
    290                 295                 300                 


Gly Lys Glu Val Arg Val Pro Ala Thr Ala Leu Cys Val Phe Asp Ala 
305                 310                 315                 320 


His Asp Gly Glu Val Asn Ala Val Gln Phe Ser Pro Gly Ser Arg Leu 
                325                 330                 335     


Leu Ala Thr Gly Gly Met Asp Arg Arg Val Lys Leu Trp Glu Val Phe 
            340                 345                 350         


Gly Glu Lys Cys Glu Phe Lys Gly Ser Leu Ser Gly Ser Asn Ala Gly 
        355                 360                 365             


Ile Thr Ser Ile Glu Phe Asp Ser Ala Gly Ser Tyr Leu Leu Ala Ala 
    370                 375                 380                 


Ser Asn Asp Phe Ala Ser Arg Ile Trp Thr Val Asp Asp Tyr Arg Leu 
385                 390                 395                 400 


Arg His Thr Leu Thr Gly His Ser Gly Lys Val Leu Ser Ala Lys Phe 
                405                 410                 415     


Leu Leu Asp Asn Ala Arg Ile Val Ser Gly Ser His Asp Arg Thr Leu 
            420                 425                 430         


Lys Leu Trp Asp Leu Arg Ser Lys Val Cys Glu Glu Ile Gln Ser Leu 
        435                 440                 445             


Cys Leu Cys Ile Cys Leu Asp Val Ser Val Glu Val Cys Val Cys Thr 
    450                 455                 460                 


Ser Glu Pro Ala Phe Met 
465                 470 


<210>  119
<211>  4291
<212>  DNA
<213>  Homosapiens

<400>  119
gggcgggtct tccggccctc tcgaaaatca tttccggcat gagccggaag accgtcccgg     60

atggcctcgg ggactgccag tgtgtggagg tgagctccgg gattgccggc attcccgctt    120

ctgctggttg cttcatgctg caggctgcgg ccgtcagccc tcgctcgcat tggtggcgct    180

gaggtgccgg ggcagcaagt gacatgtcgt cgggcctccg cgccgctgac ttcccccgct    240

ggaagcgcca catctcggag caactgaggc gccgggaccg gctgcagaga caggcgttcg    300

aggagatcat cctgcagtat aacaaattgc tggaaaagtc agatcttcat tcagtgttgg    360

cccagaaact acaggctgaa aagcatgacg taccaaacag gcacgagata agtcccggac    420

atgatggcac atggaatgac aatcagctac aagaaatggc ccaactgagg attaagcacc    480

aagaggaact gactgaatta cacaagaaac gtggggagtt agctcaactg gtgattgacc    540

tgaataacca aatgcagcgg aaggacaggg agatgcagat gaatgaagca aaaattgcag    600

aatgtttgca gactatctct gacctggaga cggagtgcct agacctgcgc actaagcttt    660

gtgaccttga aagagccaac cagaccctga aggatgaata tgatgccctg cagatcactt    720

ttactgcctt ggagggaaaa ctgaggaaaa ctacggaaga gaaccaggag ctggtcacca    780

gatggatggc tgagaaagcc caggaagcca atcggcttaa tgcagagaat gaaaaagact    840

ccaggaggcg gcaagcccgg ctgcagaaag agcttgcaga agcagcaaag gaacctctac    900

cagtcgaaca ggatgatgac attgaggtca ttgtggatga aacttctgat cacacagaag    960

agacctctcc tgtgcgagcc atcagcagag cagccacgta agtaggcagg tttgggccag   1020

ggaaaagaca gcttgaggag caatatgaag gcacatctgt ggacatgaca aagaatgcag   1080

tcagatgcac ccaacccctt accccttttc tgggacaccc agcgtcgaac acaccacaga   1140

ggtgtccagt ctttctcagt tcacctctgc ttaatgggag ggaagcagaa cacgggtggc   1200

ttcaaatgct tctaaataca aaaaaatgta gtggcttact caaatatgga cagtgaaacc   1260

ttattaagca gaatgattgt ttaggtttga tcatcctgtt tcattcttac tagggcttcc   1320

ccccgcccgc accgcccttc aagagtgggg attggttact aacagtcaga aattgtgaag   1380

ttagttagcc aggaattgtg aggttagttg tctaatgctt tatttccagg gaaattaatt   1440

taatactagg gaaccttgtt tcttttgaaa cttctaggct gggttttccc tttcccttcc   1500

cactgttttc tggcagtttg gtactgtgtt gggtttctct tggctggggt ttgggaacta   1560

agtgggaaac atattcccag ttacctgttt ttgtgggctg tttattgatt gattatttgg   1620

gcaaaatgtt tctaaggttt aaacctatcc tcccctcctc tttagtaagc gactctcgca   1680

gcctgctgga ggccttctgg attctatcac taatatcttt gggagacgct ctgtctcttc   1740

cttcccagtc ccccaggaca atgtggatac tcatcctggt tctggtaaag aagtgagggt   1800

accagctact gccttgtgtg tcttcgatgc acatgatggg gaagtcaacg ctgtgcagtt   1860

cagtccaggt tcccggttac tggccactgg aggcatggac cgcagggtta agctttggga   1920

agtatttgga gaaaaatgtg agttcaaggg ttccctatct ggcagtaatg caggaattac   1980

aagcattgaa tttgatagtg ctggatctta cctcttagca gcttcaaatg attttgcaag   2040

ccgaatctgg actgtggatg attatcgatt acggcacaca ctcacgggac acagtgggaa   2100

agtgctgtct gctaagttcc tgctggacaa tgcgcggatt gtctcaggaa gtcacgaccg   2160

gactctcaaa ctctgggatc tacgcagcaa agtctgtgag gaaattcagt ctctctgtct   2220

gtgtatatgc ttagatgtta gcgtggaggt gtgtgtttgc acgtcagagc ctgcatttat   2280

gtaatatagt ttgaatttca gatctggctt catgtttaga ggggcactga ggatagtgat   2340

agtttttctt gtttaaagct tcatttaagt gagtaactct gacaagtcag tggttagagg   2400

gtggcagcat tatgtaaaca gccacgttgg tgcctctgct tgattaatga tgtttgcatt   2460

tctttcaggc ataaagacag tgtttgcagg atccagttgc aatgatattg tctgcacaga   2520

gcaatgtgta atgagtggac attttgacaa gaaaattcgt ttctgggaca ttcgatcaga   2580

gagcatagtt cgagagatgg agctgttggg aaagattact gccctggact taaacccaga   2640

aaggactgag ctcctgagct gctcccgtga tgacttgcta aaagttattg atctccgaac   2700

aaatgctatc aagcagacat tcagtgcacc tgggttcaag tgcggctctg actggaccag   2760

agttgtcttc agccctgatg gcagttacgt ggcggcaggc tctgctgagg gctctctgta   2820

tatctggagt gtgctcacag ggaaagtgga aaaggttctt tcaaagcagc acagctcatc   2880

catcaatgcg gtggcgtggt cgccctctgg ctcgcacgtt gtcagtgtgg acaaaggatg   2940

caaagctgtg ctgtgggcac agtactgacg gggctctcag ggctgggagg accccagtgc   3000

cctcctcaga agaagcacat gggctcctgc agccctgtcc tggcaggtga tgtgctgggt   3060

atagcatgga cctcccagag aagctcaagc tatgtggcac tgtagctttg ccgtgaatgg   3120

gatttctgaa gatttgactg aggtctctct tggcctggaa gaataacact gaaaaaacct   3180

gacgctgcgg tcacttagca gaggctcagg ttcttgcctt gggaaacact actagctctg   3240

accttccata cctcacttgg gggagcacag ggccccgctg ggcctcctca ccaacggcag   3300

tgccaaaatc agcccccaca tcaaggtggt gttctctgtg ctttctctcg tccttccaaa   3360

gtcggttctg gcctaacgca tgtcccaaca ccttgggttc atttgcccgg tgaactcact   3420

ttaagcattg gattaacgga aactcccgaa ctacagaccc ctccctggtg ggttgcatga   3480

atgtgtctca ttactgctga aatgtcctca catctctttc actgttcttc agagctttct   3540

ggctctcttt cccccacaaa attcgacata tttaaaaatc tccgtgtggc tttaaaaaat   3600

ggttttttgt ttttttgttt ttttgaggtg ggagaggatg tgtgaaaatc ttttccaggg   3660

aaatgggttc gctgcagagg taaggatgtg ttcctgtatc gatctgcaga cacccagaag   3720

gtgggtgcac actgcatgct tgggggtgcc aagggattcg agacctccaa catacttgtc   3780

tgaaggtggt gattctggcc atggcccctc tgccaagcct gtgtgcgatg cccttggtgc   3840

tttagtgcaa gaagcctagg ctcagaagca cagcagcgcc atctttccgt ttcaggggtt   3900

gtgatgaagg ccaaggaaaa acatttatct ttactatttt acctacgtat aaagttttag   3960

ttcattgggt gtgcgaaaca ccctttttat cacttttaaa tttgcacttt attttttttc   4020

ttccatgctt gttctctgga catttgggga tgtgagtgtt agagctggtg agagaggagt   4080

caggtggcct tcccaccgat ggtcctggcc tccacctgcc ctctcttccc tgcctgatca   4140

ccgctttcca atttgccctt cagagaactt aagtcaagga gagttgaaat tcacaggcca   4200

gggcacatct tttatttatt tcattatgtt ggccaacaga acttgattgt aaataataat   4260

aaagaaatct gttatatact tttcaaactc c                                  4291


<210>  120
<211>  265
<212>  PRT
<213>  Homosapiens

<400>  120

Met Ser Ser Gly Leu Arg Ala Ala Asp Phe Pro Arg Trp Lys Arg His 
1               5                   10                  15      


Ile Ser Glu Gln Leu Arg Arg Arg Asp Arg Leu Gln Arg Gln Ala Phe 
            20                  25                  30          


Glu Glu Ile Ile Leu Gln Tyr Asn Lys Leu Leu Glu Lys Ser Asp Leu 
        35                  40                  45              


His Ser Val Leu Ala Gln Lys Leu Gln Ala Glu Lys His Asp Val Pro 
    50                  55                  60                  


Asn Arg His Glu Ile Ser Pro Gly His Asp Gly Thr Trp Asn Asp Asn 
65                  70                  75                  80  


Gln Leu Gln Glu Met Ala Gln Leu Arg Ile Lys His Gln Glu Glu Leu 
                85                  90                  95      


Thr Glu Leu His Lys Lys Arg Gly Glu Leu Ala Gln Leu Val Ile Asp 
            100                 105                 110         


Leu Asn Asn Gln Met Gln Arg Lys Asp Arg Glu Met Gln Met Asn Glu 
        115                 120                 125             


Ala Lys Ile Ala Glu Cys Leu Gln Thr Ile Ser Asp Leu Glu Thr Glu 
    130                 135                 140                 


Cys Leu Asp Leu Arg Thr Lys Leu Cys Asp Leu Glu Arg Ala Asn Gln 
145                 150                 155                 160 


Thr Leu Lys Asp Glu Tyr Asp Ala Leu Gln Ile Thr Phe Thr Ala Leu 
                165                 170                 175     


Glu Gly Lys Leu Arg Lys Thr Thr Glu Glu Asn Gln Glu Leu Val Thr 
            180                 185                 190         


Arg Trp Met Ala Glu Lys Ala Gln Glu Ala Asn Arg Leu Asn Ala Glu 
        195                 200                 205             


Asn Glu Lys Asp Ser Arg Arg Arg Gln Ala Arg Leu Gln Lys Glu Leu 
    210                 215                 220                 


Ala Glu Ala Ala Lys Glu Pro Leu Pro Val Glu Gln Asp Asp Asp Ile 
225                 230                 235                 240 


Glu Val Ile Val Asp Glu Thr Ser Asp His Thr Glu Glu Thr Ser Pro 
                245                 250                 255     


Val Arg Ala Ile Ser Arg Ala Ala Thr 
            260                 265 


<210>  121
<211>  3293
<212>  DNA
<213>  Homosapiens

<400>  121
gggcgggtct tccggccctc tcgaaaatca tttccggcat gagccggaag accgtcccgg     60

atggcctcgg ggactgccag tgtgtggagg tgagctccgg gattgccggc attcccgctt    120

ctgctggttg cttcatgctg caggctgcgg ccgtcagccc tcgctcgcat tggtggcgct    180

gaggtgccgg ggcagcaagt gacatgtcgt cgggcctccg cgccgctgac ttcccccgct    240

ggaagcgcca catctcggag caactgaggc gccgggaccg gctgcagaga caggcgttcg    300

aggagatcat cctgcagtat aacaaattgc tggaaaagtc agatcttcat tcagtgttgg    360

cccagaaact acaggctgaa aagcatgacg taccaaacag gcacgagata agtcccggac    420

atgatggcac atggaatgac aatcagctac aagaaatggc ccaactgagg attaagcacc    480

aagaggaact gactgaatta cacaagaaac gtggggagtt agctcaactg gtgattgacc    540

tgaataacca aatgcagcgg aaggacaggg agatgcagat gaatgaagca aaaattgcag    600

aatgtttgca gactatctct gacctggaga cggagtgcct agacctgcgc actaagcttt    660

gtgaccttga aagagccaac cagaccctga aggatgaata tgatgccctg cagatcactt    720

ttactgcctt ggagggaaaa ctgaggaaaa ctacggaaga gaaccaggag ctggtcacca    780

gatggatggc tgagaaagcc caggaagcca atcggcttaa tgcagagaat gaaaaagact    840

ccaggaggcg gcaagcccgg ctgcagaaag agcttgcaga agcagcaaag gaacctctac    900

cagtcgaaca ggatgatgac attgaggtca ttgtggatga aacttctgat cacacagaag    960

agacctctcc tgtgcgagcc atcagcagag cagccacgag acgctctgtc tcttccttcc   1020

cagtccccca ggacaatgtg gatactcatc ctggttctgg taaagaagtg agggtaccag   1080

ctactgcctt gtgtgtcttc gatgcacatg atggggaagt caacgctgtg cagttcagtc   1140

caggttcccg gttactggcc actggaggca tggaccgcag ggttaagctt tgggaagtat   1200

ttggagaaaa atgtgagttc aagggttccc tatctggcag taatgcagga attacaagca   1260

ttgaatttga tagtgctgga tcttacctct tagcagcttc aaatgatttt gcaagccgaa   1320

tctggactgt ggatgattat cgattacggc acacactcac gggacacagt gggaaagtgc   1380

tgtctgctaa gttcctgctg gacaatgcgc ggattgtctc aggaagtcac gaccggactc   1440

tcaaactctg ggatctacgc agcaaagtct gcataaagac agtgtttgca ggatccagtt   1500

gcaatgatat tgtctgcaca gagcaatgtg taatgagtgg acattttgac aagaaaattc   1560

gtttctggga cattcgatca gagagcatag ttcgagagat ggagctgttg ggaaagatta   1620

ctgccctgga cttaaaccca gaaaggactg agctcctgag ctgctcccgt gatgacttgc   1680

taaaagttat tgatctccga acaaatgcta tcaagcagac attcagtgca cctgggttca   1740

agtgcggctc tgactggacc agagttgtct tcagccctga tggcagttac gtggcggcag   1800

gctctgctga gggctctctg tatatctgga gtgtgctcac agggaaagtg gaaaaggttc   1860

tttcaaagca gcacagctca tccatcaatg cggtggcgtg gtcgccctct ggctcgcacg   1920

ttgtcagtgt ggacaaagga tgcaaagctg tgctgtgggc acagtactga cggggctctc   1980

agggctggga ggaccccagt gccctcctca gaagaagcac atgggctcct gcagccctgt   2040

cctggcaggt gatgtgctgg gtatagcatg gacctcccag agaagctcaa gctatgtggc   2100

actgtagctt tgccgtgaat gggatttctg aagatttgac tgaggtctct cttggcctgg   2160

aagaataaca ctgaaaaaac ctgacgctgc ggtcacttag cagaggctca ggttcttgcc   2220

ttgggaaaca ctactagctc tgaccttcca tacctcactt gggggagcac agggccccgc   2280

tgggcctcct caccaacggc agtgccaaaa tcagccccca catcaaggtg gtgttctctg   2340

tgctttctct cgtccttcca aagtcggttc tggcctaacg catgtcccaa caccttgggt   2400

tcatttgccc ggtgaactca ctttaagcat tggattaacg gaaactcccg aactacagac   2460

ccctccctgg tgggttgcat gaatgtgtct cattactgct gaaatgtcct cacatctctt   2520

tcactgttct tcagagcttt ctggctctct ttcccccaca aaattcgaca tatttaaaaa   2580

tctccgtgtg gctttaaaaa atggtttttt gtttttttgt ttttttgagg tgggagagga   2640

tgtgtgaaaa tcttttccag ggaaatgggt tcgctgcaga ggtaaggatg tgttcctgta   2700

tcgatctgca gacacccaga aggtgggtgc acactgcatg cttgggggtg ccaagggatt   2760

cgagacctcc aacatacttg tctgaaggtg gtgattctgg ccatggcccc tctgccaagc   2820

ctgtgtgcga tgcccttggt gctttagtgc aagaagccta ggctcagaag cacagcagcg   2880

ccatctttcc gtttcagggg ttgtgatgaa ggccaaggaa aaacatttat ctttactatt   2940

ttacctacgt ataaagtttt agttcattgg gtgtgcgaaa cacccttttt atcactttta   3000

aatttgcact ttattttttt tcttccatgc ttgttctctg gacatttggg gatgtgagtg   3060

ttagagctgg tgagagagga gtcaggtggc cttcccaccg atggtcctgg cctccacctg   3120

ccctctcttc cctgcctgat caccgctttc caatttgccc ttcagagaac ttaagtcaag   3180

gagagttgaa attcacaggc cagggcacat cttttattta tttcattatg ttggccaaca   3240

gaacttgatt gtaaataata ataaagaaat ctgttatata cttttcaaac tcc          3293


<210>  122
<211>  588
<212>  PRT
<213>  Homosapiens

<400>  122

Met Ser Ser Gly Leu Arg Ala Ala Asp Phe Pro Arg Trp Lys Arg His 
1               5                   10                  15      


Ile Ser Glu Gln Leu Arg Arg Arg Asp Arg Leu Gln Arg Gln Ala Phe 
            20                  25                  30          


Glu Glu Ile Ile Leu Gln Tyr Asn Lys Leu Leu Glu Lys Ser Asp Leu 
        35                  40                  45              


His Ser Val Leu Ala Gln Lys Leu Gln Ala Glu Lys His Asp Val Pro 
    50                  55                  60                  


Asn Arg His Glu Ile Ser Pro Gly His Asp Gly Thr Trp Asn Asp Asn 
65                  70                  75                  80  


Gln Leu Gln Glu Met Ala Gln Leu Arg Ile Lys His Gln Glu Glu Leu 
                85                  90                  95      


Thr Glu Leu His Lys Lys Arg Gly Glu Leu Ala Gln Leu Val Ile Asp 
            100                 105                 110         


Leu Asn Asn Gln Met Gln Arg Lys Asp Arg Glu Met Gln Met Asn Glu 
        115                 120                 125             


Ala Lys Ile Ala Glu Cys Leu Gln Thr Ile Ser Asp Leu Glu Thr Glu 
    130                 135                 140                 


Cys Leu Asp Leu Arg Thr Lys Leu Cys Asp Leu Glu Arg Ala Asn Gln 
145                 150                 155                 160 


Thr Leu Lys Asp Glu Tyr Asp Ala Leu Gln Ile Thr Phe Thr Ala Leu 
                165                 170                 175     


Glu Gly Lys Leu Arg Lys Thr Thr Glu Glu Asn Gln Glu Leu Val Thr 
            180                 185                 190         


Arg Trp Met Ala Glu Lys Ala Gln Glu Ala Asn Arg Leu Asn Ala Glu 
        195                 200                 205             


Asn Glu Lys Asp Ser Arg Arg Arg Gln Ala Arg Leu Gln Lys Glu Leu 
    210                 215                 220                 


Ala Glu Ala Ala Lys Glu Pro Leu Pro Val Glu Gln Asp Asp Asp Ile 
225                 230                 235                 240 


Glu Val Ile Val Asp Glu Thr Ser Asp His Thr Glu Glu Thr Ser Pro 
                245                 250                 255     


Val Arg Ala Ile Ser Arg Ala Ala Thr Arg Arg Ser Val Ser Ser Phe 
            260                 265                 270         


Pro Val Pro Gln Asp Asn Val Asp Thr His Pro Gly Ser Gly Lys Glu 
        275                 280                 285             


Val Arg Val Pro Ala Thr Ala Leu Cys Val Phe Asp Ala His Asp Gly 
    290                 295                 300                 


Glu Val Asn Ala Val Gln Phe Ser Pro Gly Ser Arg Leu Leu Ala Thr 
305                 310                 315                 320 


Gly Gly Met Asp Arg Arg Val Lys Leu Trp Glu Val Phe Gly Glu Lys 
                325                 330                 335     


Cys Glu Phe Lys Gly Ser Leu Ser Gly Ser Asn Ala Gly Ile Thr Ser 
            340                 345                 350         


Ile Glu Phe Asp Ser Ala Gly Ser Tyr Leu Leu Ala Ala Ser Asn Asp 
        355                 360                 365             


Phe Ala Ser Arg Ile Trp Thr Val Asp Asp Tyr Arg Leu Arg His Thr 
    370                 375                 380                 


Leu Thr Gly His Ser Gly Lys Val Leu Ser Ala Lys Phe Leu Leu Asp 
385                 390                 395                 400 


Asn Ala Arg Ile Val Ser Gly Ser His Asp Arg Thr Leu Lys Leu Trp 
                405                 410                 415     


Asp Leu Arg Ser Lys Val Cys Ile Lys Thr Val Phe Ala Gly Ser Ser 
            420                 425                 430         


Cys Asn Asp Ile Val Cys Thr Glu Gln Cys Val Met Ser Gly His Phe 
        435                 440                 445             


Asp Lys Lys Ile Arg Phe Trp Asp Ile Arg Ser Glu Ser Ile Val Arg 
    450                 455                 460                 


Glu Met Glu Leu Leu Gly Lys Ile Thr Ala Leu Asp Leu Asn Pro Glu 
465                 470                 475                 480 


Arg Thr Glu Leu Leu Ser Cys Ser Arg Asp Asp Leu Leu Lys Val Ile 
                485                 490                 495     


Asp Leu Arg Thr Asn Ala Ile Lys Gln Thr Phe Ser Ala Pro Gly Phe 
            500                 505                 510         


Lys Cys Gly Ser Asp Trp Thr Arg Val Val Phe Ser Pro Asp Gly Ser 
        515                 520                 525             


Tyr Val Ala Ala Gly Ser Ala Glu Gly Ser Leu Tyr Ile Trp Ser Val 
    530                 535                 540                 


Leu Thr Gly Lys Val Glu Lys Val Leu Ser Lys Gln His Ser Ser Ser 
545                 550                 555                 560 


Ile Asn Ala Val Ala Trp Ser Pro Ser Gly Ser His Val Val Ser Val 
                565                 570                 575     


Asp Lys Gly Cys Lys Ala Val Leu Trp Ala Gln Tyr 
            580                 585             


<210>  123
<211>  3976
<212>  DNA
<213>  Homosapiens

<400>  123
gggcgggtct tccggccctc tcgaaaatca tttccggcat gagccggaag accgtcccgg     60

atggcctcgg ggactgccag tgtgtggagg tgagctccgg gattgccggc attcccgctt    120

ctgctggttg cttcatgctg caggctgcgg ccgtcagccc tcgctcgcat tggtggcgct    180

gaggtgccgg ggcagcaagt gacatgtcgt cgggcctccg cgccgctgac ttcccccgct    240

ggaagcgcca catctcggag caactgaggc gccgggaccg gctgcagaga caggcgttcg    300

aggagatcat cctgcagtat aacaaattgc tggaaaagtc agatcttcat tcagtgttgg    360

cccagaaact acaggctgaa aagcatgacg taccaaacag gcacgagata agtcccggac    420

atgatggcac atggaatgac aatcagctac aagaaatggc ccaactgagg attaagcacc    480

aagaggaact gactgaatta cacaagaaac gtggggagtt agctcaactg gtgattgacc    540

tgaataacca aatgcagcgg aaggacaggg agatgcagat gaatgaagca aaaattgcag    600

aatgtttgca gactatctct gacctggaga cggagtgcct agacctgcgc actaagcttt    660

gtgaccttga aagagccaac cagaccctga aggatgaata tgatgccctg cagatcactt    720

ttactgcctt ggagggaaaa ctgaggaaaa ctacggaaga gaaccaggag ctggtcacca    780

gatggatggc tgagaaagcc caggaagcca atcggcttaa tgcagagaat gaaaaagact    840

ccaggaggcg gcaagcccgg ctgcagaaag agcttgcaga agcagcaaag gaacctctac    900

cagtcgaaca ggatgatgac attgaggtca ttgtggatga aacttctgat cacacagaag    960

agacctctcc tgtgcgagcc atcagcagag cagccactaa gcgactctcg cagcctgctg   1020

gaggccttct ggattctatc actaatatct ttgggagacg ctctgtctct tccttcccag   1080

tcccccagga caatgtggat actcatcctg gttctggtaa agaagtgagg gtaccagcta   1140

ctgccttgtg tgtcttcgat gcacatgatg gggaagtcaa cgctgtgcag ttcagtccag   1200

gttcccggtt actggccact ggaggcatgg accgcagggt taagctttgg gaagtatttg   1260

gagaaaaatg tgagttcaag ggttccctat ctggcagtaa tgcaggaatt acaagcattg   1320

aatttgatag tgctggatct tacctcttag cagcttcaaa tgattttgca agccgaatct   1380

ggactgtgga tgattatcga ttacggcaca cactcacggg acacagtggg aaagtgctgt   1440

ctgctaagtt cctgctggac aatgcgcgga ttgtctcagg aagtcacgac cggactctca   1500

aactctggga tctacgcagc aaagtctgtg aggaaattca gtctctctgt ctgtgtatat   1560

gcttagatgt tagcgtggag gtgtgtgttt gcacgtcaga gcctgcattt atgtaatata   1620

gtttgaattt cagatctggc ttcatgttta gaggggcact gaggatagtg atagtttttc   1680

ttgtttaaag cttcatttaa gtgagtaact ctgacaagtc agtggttaga gggtggcagc   1740

attatgtaaa cagccacgtt ggtgcctctg cttgattaat gatgtttgca tttctttcag   1800

gcataaagac agtgtttgca ggatccagtt gcaatgatat tgtctgcaca gagcaatgtg   1860

taatgagtgg acattttgac aagaaaattc gtttctggga cattcgatca gagagcatag   1920

ttcgagagat ggagctgttg ggaaagatta ctgccctgga cttaaaccca gaaaggactg   1980

agctcctgag ctgctcccgt gatgacttgc taaaagttat tgatctccga acaaatgcta   2040

tcaagcagac attcagtgca cctgggttca agtgcggctc tgactggacc agagttgtct   2100

tcagccctga tggcagttac gtggcggcag gctctgctga gggctctctg tatatctgga   2160

gtgtgctcac agggaaagtg gaaaaggttc tttcaaagca gcacagctca tccatcaatg   2220

cggtggcgtg gtcgccctct ggctcgcacg ttgtcagtgt ggacaaagga tgcaaagctg   2280

tgctgtgggc acagtactga cggggctctc agggctggga ggaccccagt gccctcctca   2340

gaagaagcac atgggctcct gcagccctgt cctggcaggt gatgtgctgg gtatagcatg   2400

gacctcccag agaagctcaa gctatgtggc actgtagctt tgccgtgaat gggatttctg   2460

aagatttgac tgaggtctct cttggcctgg aagaataaca ctgaaaaaac ctgacgctgc   2520

ggtcacttag cagaggctca ggttcttgcc ttgggaaaca ctactagctc tgaccttcca   2580

tacctcactt gggggagcac agggccccgc tgggcctcct caccaacggc agtgccaaaa   2640

tcagccccca catcaaggtg gtgttctctg tgctttctct cgtccttcca aagtcggttc   2700

tggcctaacg catgtcccaa caccttgggt tcatttgccc ggtgaactca ctttaagcat   2760

tggattaacg gaaactcccg aactacagac ccctccctgg tgggttgcat gaatgtgtct   2820

cattactgct gaaatgtcct cacatctctt tcactgttct tcagagcttt ctggctctct   2880

ttcccccaca aaattcgaca tatttaaaaa tctccgtgtg gctttaaaaa atggtttttt   2940

gtttttttgt ttttttgagg tgggagagga tgtgtgaaaa tcttttccag ggaaatgggt   3000

tcgctgcaga ggtaaggatg tgttcctgta tcgatctgca gacacccaga aggtgggtgc   3060

acactgcatg cttgggggtg ccaagggatt cgagacctcc aacatacttg tctgaaggtg   3120

gtgattctgg ccatggcccc tctgccaagc ctgtgtgcga tgcccttggt gctttagtgc   3180

aagaagccta ggctcagaag cacagcagcg ccatctttcc gtttcagggg ttgtgatgaa   3240

ggccaaggaa aaacatttat ctttactatt ttacctacgt ataaagtttt agttcattgg   3300

gtgtgcgaaa cacccttttt atcactttta aatttgcact ttattttttt tcttccatgc   3360

ttgttctctg gacatttggg gatgtgagtg ttagagctgg tgagagagga gtcaggtggc   3420

cttcccaccg atggtcctgg cctccacctg ccctctcttc cctgcctgat caccgctttc   3480

caatttgccc ttcagagaac ttaagtcaag gagagttgaa attcacaggc cagggcacat   3540

cttttattta tttcattatg ttggccaaca gaacttgatt gtaaataata ataaagaaat   3600

ctgttatata cttttcaaac tccatgcctc ttggtgatta ttttattctc ccttatcctt   3660

agaaagggga aagaaagtga tttctttgtt tacctggtag ttatttgtaa acaacggcta   3720

gtacttttta acggtctttt ttcattcatc atgtaagctc cattccacaa agtatctctc   3780

tctgtaaaca ccagtgttcc agtttcatgt cgcgcaaatc ttaacggaca ttggaaagat   3840

gtttcttcag aacattacca gctgcagtag aagagcccag cacggattgc tcttcagccc   3900

tctgcacgga gcctctctcc agtgaactgc cgcagcagag aggcattcac ttgtggtggc   3960

tcagattcct gacaca                                                   3976


<210>  124
<211>  470
<212>  PRT
<213>  Homosapiens

<400>  124

Met Ser Ser Gly Leu Arg Ala Ala Asp Phe Pro Arg Trp Lys Arg His 
1               5                   10                  15      


Ile Ser Glu Gln Leu Arg Arg Arg Asp Arg Leu Gln Arg Gln Ala Phe 
            20                  25                  30          


Glu Glu Ile Ile Leu Gln Tyr Asn Lys Leu Leu Glu Lys Ser Asp Leu 
        35                  40                  45              


His Ser Val Leu Ala Gln Lys Leu Gln Ala Glu Lys His Asp Val Pro 
    50                  55                  60                  


Asn Arg His Glu Ile Ser Pro Gly His Asp Gly Thr Trp Asn Asp Asn 
65                  70                  75                  80  


Gln Leu Gln Glu Met Ala Gln Leu Arg Ile Lys His Gln Glu Glu Leu 
                85                  90                  95      


Thr Glu Leu His Lys Lys Arg Gly Glu Leu Ala Gln Leu Val Ile Asp 
            100                 105                 110         


Leu Asn Asn Gln Met Gln Arg Lys Asp Arg Glu Met Gln Met Asn Glu 
        115                 120                 125             


Ala Lys Ile Ala Glu Cys Leu Gln Thr Ile Ser Asp Leu Glu Thr Glu 
    130                 135                 140                 


Cys Leu Asp Leu Arg Thr Lys Leu Cys Asp Leu Glu Arg Ala Asn Gln 
145                 150                 155                 160 


Thr Leu Lys Asp Glu Tyr Asp Ala Leu Gln Ile Thr Phe Thr Ala Leu 
                165                 170                 175     


Glu Gly Lys Leu Arg Lys Thr Thr Glu Glu Asn Gln Glu Leu Val Thr 
            180                 185                 190         


Arg Trp Met Ala Glu Lys Ala Gln Glu Ala Asn Arg Leu Asn Ala Glu 
        195                 200                 205             


Asn Glu Lys Asp Ser Arg Arg Arg Gln Ala Arg Leu Gln Lys Glu Leu 
    210                 215                 220                 


Ala Glu Ala Ala Lys Glu Pro Leu Pro Val Glu Gln Asp Asp Asp Ile 
225                 230                 235                 240 


Glu Val Ile Val Asp Glu Thr Ser Asp His Thr Glu Glu Thr Ser Pro 
                245                 250                 255     


Val Arg Ala Ile Ser Arg Ala Ala Thr Lys Arg Leu Ser Gln Pro Ala 
            260                 265                 270         


Gly Gly Leu Leu Asp Ser Ile Thr Asn Ile Phe Gly Arg Arg Ser Val 
        275                 280                 285             


Ser Ser Phe Pro Val Pro Gln Asp Asn Val Asp Thr His Pro Gly Ser 
    290                 295                 300                 


Gly Lys Glu Val Arg Val Pro Ala Thr Ala Leu Cys Val Phe Asp Ala 
305                 310                 315                 320 


His Asp Gly Glu Val Asn Ala Val Gln Phe Ser Pro Gly Ser Arg Leu 
                325                 330                 335     


Leu Ala Thr Gly Gly Met Asp Arg Arg Val Lys Leu Trp Glu Val Phe 
            340                 345                 350         


Gly Glu Lys Cys Glu Phe Lys Gly Ser Leu Ser Gly Ser Asn Ala Gly 
        355                 360                 365             


Ile Thr Ser Ile Glu Phe Asp Ser Ala Gly Ser Tyr Leu Leu Ala Ala 
    370                 375                 380                 


Ser Asn Asp Phe Ala Ser Arg Ile Trp Thr Val Asp Asp Tyr Arg Leu 
385                 390                 395                 400 


Arg His Thr Leu Thr Gly His Ser Gly Lys Val Leu Ser Ala Lys Phe 
                405                 410                 415     


Leu Leu Asp Asn Ala Arg Ile Val Ser Gly Ser His Asp Arg Thr Leu 
            420                 425                 430         


Lys Leu Trp Asp Leu Arg Ser Lys Val Cys Glu Glu Ile Gln Ser Leu 
        435                 440                 445             


Cys Leu Cys Ile Cys Leu Asp Val Ser Val Glu Val Cys Val Cys Thr 
    450                 455                 460                 


Ser Glu Pro Ala Phe Met 
465                 470 


<210>  125
<211>  4644
<212>  DNA
<213>  Homosapiens

<400>  125
gggcgggtct tccggccctc tcgaaaatca tttccggcat gagccggaag accgtcccgg     60

atggcctcgg ggactgccag tgtgtggagg tgagctccgg gattgccggc attcccgctt    120

ctgctggttg cttcatgctg caggctgcgg ccgtcagccc tcgctcgcat tggtggcgct    180

gaggtgccgg ggcagcaagt gacatgtcgt cgggcctccg cgccgctgac ttcccccgct    240

ggaagcgcca catctcggag caactgaggc gccgggaccg gctgcagaga caggcgttcg    300

aggagatcat cctgcagtat aacaaattgc tggaaaagtc agatcttcat tcagtgttgg    360

cccagaaact acaggctgaa aagcatgacg taccaaacag gcacgagata agtcccggac    420

atgatggcac atggaatgac aatcagctac aagaaatggc ccaactgagg attaagcacc    480

aagaggaact gactgaatta cacaagaaac gtggggagtt agctcaactg gtgattgacc    540

tgaataacca aatgcagcgg aaggacaggg agatgcagat gaatgaagca aaaattgcag    600

aatgtttgca gactatctct gacctggaga cggagtgcct agacctgcgc actaagcttt    660

gtgaccttga aagagccaac cagaccctga aggatgaata tgatgccctg cagatcactt    720

ttactgcctt ggagggaaaa ctgaggaaaa ctacggaaga gaaccaggag ctggtcacca    780

gatggatggc tgagaaagcc caggaagcca atcggcttaa tgcagagaat gaaaaagact    840

ccaggaggcg gcaagcccgg ctgcagaaag agcttgcaga agcagcaaag gaacctctac    900

cagtcgaaca ggatgatgac attgaggtca ttgtggatga aacttctgat cacacagaag    960

agacctctcc tgtgcgagcc atcagcagag cagccacgta agtaggcagg tttgggccag   1020

ggaaaagaca gcttgaggag caatatgaag gcacatctgt ggacatgaca aagaatgcag   1080

tcagatgcac ccaacccctt accccttttc tgggacaccc agcgtcgaac acaccacaga   1140

ggtgtccagt ctttctcagt tcacctctgc ttaatgggag ggaagcagaa cacgggtggc   1200

ttcaaatgct tctaaataca aaaaaatgta gtggcttact caaatatgga cagtgaaacc   1260

ttattaagca gaatgattgt ttaggtttga tcatcctgtt tcattcttac tagggcttcc   1320

ccccgcccgc accgcccttc aagagtgggg attggttact aacagtcaga aattgtgaag   1380

ttagttagcc aggaattgtg aggttagttg tctaatgctt tatttccagg gaaattaatt   1440

taatactagg gaaccttgtt tcttttgaaa cttctaggct gggttttccc tttcccttcc   1500

cactgttttc tggcagtttg gtactgtgtt gggtttctct tggctggggt ttgggaacta   1560

agtgggaaac atattcccag ttacctgttt ttgtgggctg tttattgatt gattatttgg   1620

gcaaaatgtt tctaaggttt aaacctatcc tcccctcctc tttagtaagc gactctcgca   1680

gcctgctgga ggccttctgg attctatcac taatatcttt gggagacgct ctgtctcttc   1740

cttcccagtc ccccaggaca atgtggatac tcatcctggt tctggtaaag aagtgagggt   1800

accagctact gccttgtgtg tcttcgatgc acatgatggg gaagtcaacg ctgtgcagtt   1860

cagtccaggt tcccggttac tggccactgg aggcatggac cgcagggtta agctttggga   1920

agtatttgga gaaaaatgtg agttcaaggg ttccctatct ggcagtaatg caggaattac   1980

aagcattgaa tttgatagtg ctggatctta cctcttagca gcttcaaatg attttgcaag   2040

ccgaatctgg actgtggatg attatcgatt acggcacaca ctcacgggac acagtgggaa   2100

agtgctgtct gctaagttcc tgctggacaa tgcgcggatt gtctcaggaa gtcacgaccg   2160

gactctcaaa ctctgggatc tacgcagcaa agtctgtgag gaaattcagt ctctctgtct   2220

gtgtatatgc ttagatgtta gcgtggaggt gtgtgtttgc acgtcagagc ctgcatttat   2280

gtaatatagt ttgaatttca gatctggctt catgtttaga ggggcactga ggatagtgat   2340

agtttttctt gtttaaagct tcatttaagt gagtaactct gacaagtcag tggttagagg   2400

gtggcagcat tatgtaaaca gccacgttgg tgcctctgct tgattaatga tgtttgcatt   2460

tctttcaggc ataaagacag tgtttgcagg atccagttgc aatgatattg tctgcacaga   2520

gcaatgtgta atgagtggac attttgacaa gaaaattcgt ttctgggaca ttcgatcaga   2580

gagcatagtt cgagagatgg agctgttggg aaagattact gccctggact taaacccaga   2640

aaggactgag ctcctgagct gctcccgtga tgacttgcta aaagttattg atctccgaac   2700

aaatgctatc aagcagacat tcagtgcacc tgggttcaag tgcggctctg actggaccag   2760

agttgtcttc agccctgatg gcagttacgt ggcggcaggc tctgctgagg gctctctgta   2820

tatctggagt gtgctcacag ggaaagtgga aaaggttctt tcaaagcagc acagctcatc   2880

catcaatgcg gtggcgtggt cgccctctgg ctcgcacgtt gtcagtgtgg acaaaggatg   2940

caaagctgtg ctgtgggcac agtactgacg gggctctcag ggctgggagg accccagtgc   3000

cctcctcaga agaagcacat gggctcctgc agccctgtcc tggcaggtga tgtgctgggt   3060

atagcatgga cctcccagag aagctcaagc tatgtggcac tgtagctttg ccgtgaatgg   3120

gatttctgaa gatttgactg aggtctctct tggcctggaa gaataacact gaaaaaacct   3180

gacgctgcgg tcacttagca gaggctcagg ttcttgcctt gggaaacact actagctctg   3240

accttccata cctcacttgg gggagcacag ggccccgctg ggcctcctca ccaacggcag   3300

tgccaaaatc agcccccaca tcaaggtggt gttctctgtg ctttctctcg tccttccaaa   3360

gtcggttctg gcctaacgca tgtcccaaca ccttgggttc atttgcccgg tgaactcact   3420

ttaagcattg gattaacgga aactcccgaa ctacagaccc ctccctggtg ggttgcatga   3480

atgtgtctca ttactgctga aatgtcctca catctctttc actgttcttc agagctttct   3540

ggctctcttt cccccacaaa attcgacata tttaaaaatc tccgtgtggc tttaaaaaat   3600

ggttttttgt ttttttgttt ttttgaggtg ggagaggatg tgtgaaaatc ttttccaggg   3660

aaatgggttc gctgcagagg taaggatgtg ttcctgtatc gatctgcaga cacccagaag   3720

gtgggtgcac actgcatgct tgggggtgcc aagggattcg agacctccaa catacttgtc   3780

tgaaggtggt gattctggcc atggcccctc tgccaagcct gtgtgcgatg cccttggtgc   3840

tttagtgcaa gaagcctagg ctcagaagca cagcagcgcc atctttccgt ttcaggggtt   3900

gtgatgaagg ccaaggaaaa acatttatct ttactatttt acctacgtat aaagttttag   3960

ttcattgggt gtgcgaaaca ccctttttat cacttttaaa tttgcacttt attttttttc   4020

ttccatgctt gttctctgga catttgggga tgtgagtgtt agagctggtg agagaggagt   4080

caggtggcct tcccaccgat ggtcctggcc tccacctgcc ctctcttccc tgcctgatca   4140

ccgctttcca atttgccctt cagagaactt aagtcaagga gagttgaaat tcacaggcca   4200

gggcacatct tttatttatt tcattatgtt ggccaacaga acttgattgt aaataataat   4260

aaagaaatct gttatatact tttcaaactc catgcctctt ggtgattatt ttattctccc   4320

ttatccttag aaaggggaaa gaaagtgatt tctttgttta cctggtagtt atttgtaaac   4380

aacggctagt actttttaac ggtctttttt cattcatcat gtaagctcca ttccacaaag   4440

tatctctctc tgtaaacacc agtgttccag tttcatgtcg cgcaaatctt aacggacatt   4500

ggaaagatgt ttcttcagaa cattaccagc tgcagtagaa gagcccagca cggattgctc   4560

ttcagccctc tgcacggagc ctctctccag tgaactgccg cagcagagag gcattcactt   4620

gtggtggctc agattcctga caca                                          4644


<210>  126
<211>  265
<212>  PRT
<213>  Homosapiens

<400>  126

Met Ser Ser Gly Leu Arg Ala Ala Asp Phe Pro Arg Trp Lys Arg His 
1               5                   10                  15      


Ile Ser Glu Gln Leu Arg Arg Arg Asp Arg Leu Gln Arg Gln Ala Phe 
            20                  25                  30          


Glu Glu Ile Ile Leu Gln Tyr Asn Lys Leu Leu Glu Lys Ser Asp Leu 
        35                  40                  45              


His Ser Val Leu Ala Gln Lys Leu Gln Ala Glu Lys His Asp Val Pro 
    50                  55                  60                  


Asn Arg His Glu Ile Ser Pro Gly His Asp Gly Thr Trp Asn Asp Asn 
65                  70                  75                  80  


Gln Leu Gln Glu Met Ala Gln Leu Arg Ile Lys His Gln Glu Glu Leu 
                85                  90                  95      


Thr Glu Leu His Lys Lys Arg Gly Glu Leu Ala Gln Leu Val Ile Asp 
            100                 105                 110         


Leu Asn Asn Gln Met Gln Arg Lys Asp Arg Glu Met Gln Met Asn Glu 
        115                 120                 125             


Ala Lys Ile Ala Glu Cys Leu Gln Thr Ile Ser Asp Leu Glu Thr Glu 
    130                 135                 140                 


Cys Leu Asp Leu Arg Thr Lys Leu Cys Asp Leu Glu Arg Ala Asn Gln 
145                 150                 155                 160 


Thr Leu Lys Asp Glu Tyr Asp Ala Leu Gln Ile Thr Phe Thr Ala Leu 
                165                 170                 175     


Glu Gly Lys Leu Arg Lys Thr Thr Glu Glu Asn Gln Glu Leu Val Thr 
            180                 185                 190         


Arg Trp Met Ala Glu Lys Ala Gln Glu Ala Asn Arg Leu Asn Ala Glu 
        195                 200                 205             


Asn Glu Lys Asp Ser Arg Arg Arg Gln Ala Arg Leu Gln Lys Glu Leu 
    210                 215                 220                 


Ala Glu Ala Ala Lys Glu Pro Leu Pro Val Glu Gln Asp Asp Asp Ile 
225                 230                 235                 240 


Glu Val Ile Val Asp Glu Thr Ser Asp His Thr Glu Glu Thr Ser Pro 
                245                 250                 255     


Val Arg Ala Ile Ser Arg Ala Ala Thr 
            260                 265 


<210>  127
<211>  3646
<212>  DNA
<213>  Homosapiens

<400>  127
gggcgggtct tccggccctc tcgaaaatca tttccggcat gagccggaag accgtcccgg     60

atggcctcgg ggactgccag tgtgtggagg tgagctccgg gattgccggc attcccgctt    120

ctgctggttg cttcatgctg caggctgcgg ccgtcagccc tcgctcgcat tggtggcgct    180

gaggtgccgg ggcagcaagt gacatgtcgt cgggcctccg cgccgctgac ttcccccgct    240

ggaagcgcca catctcggag caactgaggc gccgggaccg gctgcagaga caggcgttcg    300

aggagatcat cctgcagtat aacaaattgc tggaaaagtc agatcttcat tcagtgttgg    360

cccagaaact acaggctgaa aagcatgacg taccaaacag gcacgagata agtcccggac    420

atgatggcac atggaatgac aatcagctac aagaaatggc ccaactgagg attaagcacc    480

aagaggaact gactgaatta cacaagaaac gtggggagtt agctcaactg gtgattgacc    540

tgaataacca aatgcagcgg aaggacaggg agatgcagat gaatgaagca aaaattgcag    600

aatgtttgca gactatctct gacctggaga cggagtgcct agacctgcgc actaagcttt    660

gtgaccttga aagagccaac cagaccctga aggatgaata tgatgccctg cagatcactt    720

ttactgcctt ggagggaaaa ctgaggaaaa ctacggaaga gaaccaggag ctggtcacca    780

gatggatggc tgagaaagcc caggaagcca atcggcttaa tgcagagaat gaaaaagact    840

ccaggaggcg gcaagcccgg ctgcagaaag agcttgcaga agcagcaaag gaacctctac    900

cagtcgaaca ggatgatgac attgaggtca ttgtggatga aacttctgat cacacagaag    960

agacctctcc tgtgcgagcc atcagcagag cagccacgag acgctctgtc tcttccttcc   1020

cagtccccca ggacaatgtg gatactcatc ctggttctgg taaagaagtg agggtaccag   1080

ctactgcctt gtgtgtcttc gatgcacatg atggggaagt caacgctgtg cagttcagtc   1140

caggttcccg gttactggcc actggaggca tggaccgcag ggttaagctt tgggaagtat   1200

ttggagaaaa atgtgagttc aagggttccc tatctggcag taatgcagga attacaagca   1260

ttgaatttga tagtgctgga tcttacctct tagcagcttc aaatgatttt gcaagccgaa   1320

tctggactgt ggatgattat cgattacggc acacactcac gggacacagt gggaaagtgc   1380

tgtctgctaa gttcctgctg gacaatgcgc ggattgtctc aggaagtcac gaccggactc   1440

tcaaactctg ggatctacgc agcaaagtct gcataaagac agtgtttgca ggatccagtt   1500

gcaatgatat tgtctgcaca gagcaatgtg taatgagtgg acattttgac aagaaaattc   1560

gtttctggga cattcgatca gagagcatag ttcgagagat ggagctgttg ggaaagatta   1620

ctgccctgga cttaaaccca gaaaggactg agctcctgag ctgctcccgt gatgacttgc   1680

taaaagttat tgatctccga acaaatgcta tcaagcagac attcagtgca cctgggttca   1740

agtgcggctc tgactggacc agagttgtct tcagccctga tggcagttac gtggcggcag   1800

gctctgctga gggctctctg tatatctgga gtgtgctcac agggaaagtg gaaaaggttc   1860

tttcaaagca gcacagctca tccatcaatg cggtggcgtg gtcgccctct ggctcgcacg   1920

ttgtcagtgt ggacaaagga tgcaaagctg tgctgtgggc acagtactga cggggctctc   1980

agggctggga ggaccccagt gccctcctca gaagaagcac atgggctcct gcagccctgt   2040

cctggcaggt gatgtgctgg gtatagcatg gacctcccag agaagctcaa gctatgtggc   2100

actgtagctt tgccgtgaat gggatttctg aagatttgac tgaggtctct cttggcctgg   2160

aagaataaca ctgaaaaaac ctgacgctgc ggtcacttag cagaggctca ggttcttgcc   2220

ttgggaaaca ctactagctc tgaccttcca tacctcactt gggggagcac agggccccgc   2280

tgggcctcct caccaacggc agtgccaaaa tcagccccca catcaaggtg gtgttctctg   2340

tgctttctct cgtccttcca aagtcggttc tggcctaacg catgtcccaa caccttgggt   2400

tcatttgccc ggtgaactca ctttaagcat tggattaacg gaaactcccg aactacagac   2460

ccctccctgg tgggttgcat gaatgtgtct cattactgct gaaatgtcct cacatctctt   2520

tcactgttct tcagagcttt ctggctctct ttcccccaca aaattcgaca tatttaaaaa   2580

tctccgtgtg gctttaaaaa atggtttttt gtttttttgt ttttttgagg tgggagagga   2640

tgtgtgaaaa tcttttccag ggaaatgggt tcgctgcaga ggtaaggatg tgttcctgta   2700

tcgatctgca gacacccaga aggtgggtgc acactgcatg cttgggggtg ccaagggatt   2760

cgagacctcc aacatacttg tctgaaggtg gtgattctgg ccatggcccc tctgccaagc   2820

ctgtgtgcga tgcccttggt gctttagtgc aagaagccta ggctcagaag cacagcagcg   2880

ccatctttcc gtttcagggg ttgtgatgaa ggccaaggaa aaacatttat ctttactatt   2940

ttacctacgt ataaagtttt agttcattgg gtgtgcgaaa cacccttttt atcactttta   3000

aatttgcact ttattttttt tcttccatgc ttgttctctg gacatttggg gatgtgagtg   3060

ttagagctgg tgagagagga gtcaggtggc cttcccaccg atggtcctgg cctccacctg   3120

ccctctcttc cctgcctgat caccgctttc caatttgccc ttcagagaac ttaagtcaag   3180

gagagttgaa attcacaggc cagggcacat cttttattta tttcattatg ttggccaaca   3240

gaacttgatt gtaaataata ataaagaaat ctgttatata cttttcaaac tccatgcctc   3300

ttggtgatta ttttattctc ccttatcctt agaaagggga aagaaagtga tttctttgtt   3360

tacctggtag ttatttgtaa acaacggcta gtacttttta acggtctttt ttcattcatc   3420

atgtaagctc cattccacaa agtatctctc tctgtaaaca ccagtgttcc agtttcatgt   3480

cgcgcaaatc ttaacggaca ttggaaagat gtttcttcag aacattacca gctgcagtag   3540

aagagcccag cacggattgc tcttcagccc tctgcacgga gcctctctcc agtgaactgc   3600

cgcagcagag aggcattcac ttgtggtggc tcagattcct gacaca                  3646


<210>  128
<211>  588
<212>  PRT
<213>  Homosapiens

<400>  128

Met Ser Ser Gly Leu Arg Ala Ala Asp Phe Pro Arg Trp Lys Arg His 
1               5                   10                  15      


Ile Ser Glu Gln Leu Arg Arg Arg Asp Arg Leu Gln Arg Gln Ala Phe 
            20                  25                  30          


Glu Glu Ile Ile Leu Gln Tyr Asn Lys Leu Leu Glu Lys Ser Asp Leu 
        35                  40                  45              


His Ser Val Leu Ala Gln Lys Leu Gln Ala Glu Lys His Asp Val Pro 
    50                  55                  60                  


Asn Arg His Glu Ile Ser Pro Gly His Asp Gly Thr Trp Asn Asp Asn 
65                  70                  75                  80  


Gln Leu Gln Glu Met Ala Gln Leu Arg Ile Lys His Gln Glu Glu Leu 
                85                  90                  95      


Thr Glu Leu His Lys Lys Arg Gly Glu Leu Ala Gln Leu Val Ile Asp 
            100                 105                 110         


Leu Asn Asn Gln Met Gln Arg Lys Asp Arg Glu Met Gln Met Asn Glu 
        115                 120                 125             


Ala Lys Ile Ala Glu Cys Leu Gln Thr Ile Ser Asp Leu Glu Thr Glu 
    130                 135                 140                 


Cys Leu Asp Leu Arg Thr Lys Leu Cys Asp Leu Glu Arg Ala Asn Gln 
145                 150                 155                 160 


Thr Leu Lys Asp Glu Tyr Asp Ala Leu Gln Ile Thr Phe Thr Ala Leu 
                165                 170                 175     


Glu Gly Lys Leu Arg Lys Thr Thr Glu Glu Asn Gln Glu Leu Val Thr 
            180                 185                 190         


Arg Trp Met Ala Glu Lys Ala Gln Glu Ala Asn Arg Leu Asn Ala Glu 
        195                 200                 205             


Asn Glu Lys Asp Ser Arg Arg Arg Gln Ala Arg Leu Gln Lys Glu Leu 
    210                 215                 220                 


Ala Glu Ala Ala Lys Glu Pro Leu Pro Val Glu Gln Asp Asp Asp Ile 
225                 230                 235                 240 


Glu Val Ile Val Asp Glu Thr Ser Asp His Thr Glu Glu Thr Ser Pro 
                245                 250                 255     


Val Arg Ala Ile Ser Arg Ala Ala Thr Arg Arg Ser Val Ser Ser Phe 
            260                 265                 270         


Pro Val Pro Gln Asp Asn Val Asp Thr His Pro Gly Ser Gly Lys Glu 
        275                 280                 285             


Val Arg Val Pro Ala Thr Ala Leu Cys Val Phe Asp Ala His Asp Gly 
    290                 295                 300                 


Glu Val Asn Ala Val Gln Phe Ser Pro Gly Ser Arg Leu Leu Ala Thr 
305                 310                 315                 320 


Gly Gly Met Asp Arg Arg Val Lys Leu Trp Glu Val Phe Gly Glu Lys 
                325                 330                 335     


Cys Glu Phe Lys Gly Ser Leu Ser Gly Ser Asn Ala Gly Ile Thr Ser 
            340                 345                 350         


Ile Glu Phe Asp Ser Ala Gly Ser Tyr Leu Leu Ala Ala Ser Asn Asp 
        355                 360                 365             


Phe Ala Ser Arg Ile Trp Thr Val Asp Asp Tyr Arg Leu Arg His Thr 
    370                 375                 380                 


Leu Thr Gly His Ser Gly Lys Val Leu Ser Ala Lys Phe Leu Leu Asp 
385                 390                 395                 400 


Asn Ala Arg Ile Val Ser Gly Ser His Asp Arg Thr Leu Lys Leu Trp 
                405                 410                 415     


Asp Leu Arg Ser Lys Val Cys Ile Lys Thr Val Phe Ala Gly Ser Ser 
            420                 425                 430         


Cys Asn Asp Ile Val Cys Thr Glu Gln Cys Val Met Ser Gly His Phe 
        435                 440                 445             


Asp Lys Lys Ile Arg Phe Trp Asp Ile Arg Ser Glu Ser Ile Val Arg 
    450                 455                 460                 


Glu Met Glu Leu Leu Gly Lys Ile Thr Ala Leu Asp Leu Asn Pro Glu 
465                 470                 475                 480 


Arg Thr Glu Leu Leu Ser Cys Ser Arg Asp Asp Leu Leu Lys Val Ile 
                485                 490                 495     


Asp Leu Arg Thr Asn Ala Ile Lys Gln Thr Phe Ser Ala Pro Gly Phe 
            500                 505                 510         


Lys Cys Gly Ser Asp Trp Thr Arg Val Val Phe Ser Pro Asp Gly Ser 
        515                 520                 525             


Tyr Val Ala Ala Gly Ser Ala Glu Gly Ser Leu Tyr Ile Trp Ser Val 
    530                 535                 540                 


Leu Thr Gly Lys Val Glu Lys Val Leu Ser Lys Gln His Ser Ser Ser 
545                 550                 555                 560 


Ile Asn Ala Val Ala Trp Ser Pro Ser Gly Ser His Val Val Ser Val 
                565                 570                 575     


Asp Lys Gly Cys Lys Ala Val Leu Trp Ala Gln Tyr 
            580                 585             


<210>  129
<211>  2889
<212>  DNA
<213>  Homosapiens

<400>  129
atttccggca tgagccggaa gaccgtcccg gatggcctcg gggactgcca gtgtgtggag     60

gtgagctccg ggattgccgg cattcccgct tctgctggtt gcttcatgct gcaggctgcg    120

gccgtcagcc ctcgctcgca ttggtggcgc tgaggtgccg gggcagcaag tgacatgtcg    180

tcgggcctcc gcgccgctga cttcccccgc tggaagcgcc acatctcgga gcaactgagg    240

cgccgggacc ggctgcagag acaggcgttc gaggagatca tcctgcagta taacaaattg    300

ctggaaaagt cagatcttca ttcagtgttg gcccagaaac tacaggctga aaagcatgac    360

gtaccaaaca ggcacgagat aaggaggcgg caagcccggc tgcagaaaga gcttgcagaa    420

gcagcaaagg aacctctacc agtcgaacag gatgatgaca ttgaggtcat tgtggatgaa    480

acttctgatc acacagaaga gacctctcct gtgcgagcca tcagcagagc agccactaag    540

cgactctcgc agcctgctgg aggccttctg gattctatca ctaatatctt tgggagacgc    600

tctgtctctt ccttcccagt cccccaggac aatgtggata ctcatcctgg ttctggtaaa    660

gaagtgaggg taccagctac tgccttgtgt gtcttcgatg cacatgatgg ggaagtcaac    720

gctgtgcagt tcagtccagg ttcccggtta ctggccactg gaggcatgga ccgcagggtt    780

aagctttggg aagtatttgg agaaaaatgt gagttcaagg gttccctatc tggcagtaat    840

gcaggaatta caagcattga atttgatagt gctggatctt acctcttagc agcttcaaat    900

gattttgcaa gccgaatctg gactgtggat gattatcgat tacggcacac actcacggga    960

cacagtggga aagtgctgtc tgctaagttc ctgctggaca atgcgcggat tgtctcagga   1020

agtcacgacc ggactctcaa actctgggat ctacgcagca aagtctgcat aaagacagtg   1080

tttgcaggat ccagttgcaa tgatattgtc tgcacagagc aatgtgtaat gagtggacat   1140

tttgacaaga aaattcgttt ctgggacatt cgatcagaga gcatagttcg agagatggag   1200

ctgttgggaa agattactgc cctggactta aacccagaaa ggactgagct cctgagctgc   1260

tcccgtgatg acttgctaaa agttattgat ctccgaacaa atgctatcaa gcagacattc   1320

agtgcacctg ggttcaagtg cggctctgac tggaccagag ttgtcttcag ccctgatggc   1380

agttacgtgg cggcaggctc tgctgagggc tctctgtata tctggagtgt gctcacaggg   1440

aaagtggaaa aggttctttc aaagcagcac agctcatcca tcaatgcggt ggcgtggtcg   1500

ccctctggct cgcacgttgt cagtgtggac aaaggatgca aagctgtgct gtgggcacag   1560

tactgacggg gctctcaggg ctgggaggac cccagtgccc tcctcagaag aagcacatgg   1620

gctcctgcag ccctgtcctg gcaggtgatg tgctgggtat agcatggacc tcccagagaa   1680

gctcaagcta tgtggcactg tagctttgcc gtgaatggga tttctgaaga tttgactgag   1740

gtctctcttg gcctggaaga ataacactga aaaaacctga cgctgcggtc acttagcaga   1800

ggctcaggtt cttgccttgg gaaacactac tagctctgac cttccatacc tcacttgggg   1860

gagcacaggg ccccgctggg cctcctcacc aacggcagtg ccaaaatcag cccccacatc   1920

aaggtggtgt tctctgtgct ttctctcgtc cttccaaagt cggttctggc ctaacgcatg   1980

tcccaacacc ttgggttcat ttgcccggtg aactcacttt aagcattgga ttaacggaaa   2040

ctcccgaact acagacccct ccctggtggg ttgcatgaat gtgtctcatt actgctgaaa   2100

tgtcctcaca tctctttcac tgttcttcag agctttctgg ctctctttcc cccacaaaat   2160

tcgacatatt taaaaatctc cgtgtggctt taaaaaatgg ttttttgttt ttttgttttt   2220

ttgaggtggg agaggatgtg tgaaaatctt ttccagggaa atgggttcgc tgcagaggta   2280

aggatgtgtt cctgtatcga tctgcagaca cccagaaggt gggtgcacac tgcatgcttg   2340

ggggtgccaa gggattcgag acctccaaca tacttgtctg aaggtggtga ttctggccat   2400

ggcccctctg ccaagcctgt gtgcgatgcc cttggtgctt tagtgcaaga agcctaggct   2460

cagaagcaca gcagcgccat ctttccgttt caggggttgt gatgaaggcc aaggaaaaac   2520

atttatcttt actattttac ctacgtataa agttttagtt cattgggtgt gcgaaacacc   2580

ctttttatca cttttaaatt tgcactttat tttttttctt ccatgcttgt tctctggaca   2640

tttggggatg tgagtgttag agctggtgag agaggagtca ggtggccttc ccaccgatgg   2700

tcctggcctc cacctgccct ctcttccctg cctgatcacc gctttccaat ttgcccttca   2760

gagaacttaa gtcaaggaga gttgaaattc acaggccagg gcacatcttt tatttatttc   2820

attatgttgg ccaacagaac ttgattgtaa ataataataa agaaatctgt tatatacttt   2880

tcaaactcc                                                           2889


<210>  130
<211>  463
<212>  PRT
<213>  Homosapiens

<400>  130

Met Ser Ser Gly Leu Arg Ala Ala Asp Phe Pro Arg Trp Lys Arg His 
1               5                   10                  15      


Ile Ser Glu Gln Leu Arg Arg Arg Asp Arg Leu Gln Arg Gln Ala Phe 
            20                  25                  30          


Glu Glu Ile Ile Leu Gln Tyr Asn Lys Leu Leu Glu Lys Ser Asp Leu 
        35                  40                  45              


His Ser Val Leu Ala Gln Lys Leu Gln Ala Glu Lys His Asp Val Pro 
    50                  55                  60                  


Asn Arg His Glu Ile Arg Arg Arg Gln Ala Arg Leu Gln Lys Glu Leu 
65                  70                  75                  80  


Ala Glu Ala Ala Lys Glu Pro Leu Pro Val Glu Gln Asp Asp Asp Ile 
                85                  90                  95      


Glu Val Ile Val Asp Glu Thr Ser Asp His Thr Glu Glu Thr Ser Pro 
            100                 105                 110         


Val Arg Ala Ile Ser Arg Ala Ala Thr Lys Arg Leu Ser Gln Pro Ala 
        115                 120                 125             


Gly Gly Leu Leu Asp Ser Ile Thr Asn Ile Phe Gly Arg Arg Ser Val 
    130                 135                 140                 


Ser Ser Phe Pro Val Pro Gln Asp Asn Val Asp Thr His Pro Gly Ser 
145                 150                 155                 160 


Gly Lys Glu Val Arg Val Pro Ala Thr Ala Leu Cys Val Phe Asp Ala 
                165                 170                 175     


His Asp Gly Glu Val Asn Ala Val Gln Phe Ser Pro Gly Ser Arg Leu 
            180                 185                 190         


Leu Ala Thr Gly Gly Met Asp Arg Arg Val Lys Leu Trp Glu Val Phe 
        195                 200                 205             


Gly Glu Lys Cys Glu Phe Lys Gly Ser Leu Ser Gly Ser Asn Ala Gly 
    210                 215                 220                 


Ile Thr Ser Ile Glu Phe Asp Ser Ala Gly Ser Tyr Leu Leu Ala Ala 
225                 230                 235                 240 


Ser Asn Asp Phe Ala Ser Arg Ile Trp Thr Val Asp Asp Tyr Arg Leu 
                245                 250                 255     


Arg His Thr Leu Thr Gly His Ser Gly Lys Val Leu Ser Ala Lys Phe 
            260                 265                 270         


Leu Leu Asp Asn Ala Arg Ile Val Ser Gly Ser His Asp Arg Thr Leu 
        275                 280                 285             


Lys Leu Trp Asp Leu Arg Ser Lys Val Cys Ile Lys Thr Val Phe Ala 
    290                 295                 300                 


Gly Ser Ser Cys Asn Asp Ile Val Cys Thr Glu Gln Cys Val Met Ser 
305                 310                 315                 320 


Gly His Phe Asp Lys Lys Ile Arg Phe Trp Asp Ile Arg Ser Glu Ser 
                325                 330                 335     


Ile Val Arg Glu Met Glu Leu Leu Gly Lys Ile Thr Ala Leu Asp Leu 
            340                 345                 350         


Asn Pro Glu Arg Thr Glu Leu Leu Ser Cys Ser Arg Asp Asp Leu Leu 
        355                 360                 365             


Lys Val Ile Asp Leu Arg Thr Asn Ala Ile Lys Gln Thr Phe Ser Ala 
    370                 375                 380                 


Pro Gly Phe Lys Cys Gly Ser Asp Trp Thr Arg Val Val Phe Ser Pro 
385                 390                 395                 400 


Asp Gly Ser Tyr Val Ala Ala Gly Ser Ala Glu Gly Ser Leu Tyr Ile 
                405                 410                 415     


Trp Ser Val Leu Thr Gly Lys Val Glu Lys Val Leu Ser Lys Gln His 
            420                 425                 430         


Ser Ser Ser Ile Asn Ala Val Ala Trp Ser Pro Ser Gly Ser His Val 
        435                 440                 445             


Val Ser Val Asp Lys Gly Cys Lys Ala Val Leu Trp Ala Gln Tyr 
    450                 455                 460             


<210>  131
<211>  1789
<212>  DNA
<213>  Homosapiens

<400>  131
ccggcatgag ccggaagacc gtcccggatg gcctcgggga ctgccagtgt gtggaggtga     60

gctccgggat tgccggcatt cccgcttctg ctggttgctt catgctgcag gctgcggccg    120

tcagccctcg ctcgcattgg tggcgctgag gtgccggggc agcaagtgac atgtcgtcgg    180

gcctccgcgc cgctgacttc ccccgctgga agcgccacat ctcggagcaa ctgaggcgcc    240

gggaccggct gcagagacag gcgttcgagg agatcatcct gcagtataac aaattgctgg    300

aaaagtcaga tcttcattca gtgttggccc agaaactaca ggctgaaaag catgacgtac    360

caaacaggca cgagataagt cccggacatg atggcacatg gaatgacaat cagctacaag    420

aaatggccca actgaggatt aagcaccaag aggaactgac tgaattacac aagaaacgtg    480

gggagttagc tcaactggtg attgacctga ataaccaaat gcagcggaag gacagggaga    540

tgcagaaaga gcttgcagaa gcagcaaagg aacctctacc agtcgaacag gatgatgaca    600

ttgaggtcat tgtggatgaa acttctgatc acacagaaga gacctctcct gtgcgagcca    660

tcagcagagc agccactaag cgactctcgc agcctgctgg aggccttctg gattctatca    720

ctaatatctt tgggagacgc tctgtctctt ccttcccagt cccccaggac aatgtggata    780

ctcatcctgg ttctggtaaa gaagtgaggg taccagctac tgccttgtgt gtcttcgatg    840

cacatgatgg ggaagtcaac gctgtgcagt tcagtccagg ttcccggtta ctggccactg    900

gaggcatgga ccgcagggtt aagctttggg aagtatttgg agaaaaatgt gagttcaagg    960

gttccctatc tggcagtaat gcaggaatta caagcattga atttgatagt gctggatctt   1020

acctcttagc agcttcaaat gattttgcaa gccgaatctg gactgtggat gattatcgat   1080

tacgggtaag acccagttaa gaaagttagt gcaatctcca aacttcatgt ggtgttatca   1140

aggcacaaac tggcaggtgc ttaattaggg gactttgttt tcccaaaaat catgcttgat   1200

tcaccctgcc cttcctttcc tccttgggga aatctgtgtt tccactttat actctttgtc   1260

caaaactcag tttcaaaata tttgcaatgg gaccctcaca tttgcatgaa aaccttggaa   1320

tactcttcat aaggactaaa tactttggta gatagcaatt ttggcttaat ggcacagaac   1380

ttagcaacag catgtgaatt gtgattcctg tgggctctaa aacctaatta cctaaagtgg   1440

gatatagaag tacaaatgga tgtatcatag ggataagaca attctgaaac aaaaactcca   1500

agctgagaaa gaggggacag gtgtcagagc agggagaaat gattggatgt tgaggaaagc   1560

tgcatttgaa ccaaaacttg ccaagaattc tcttggcatc tgacagagag accaaaactt   1620

ggttgtatca tttttgattg gggcaggggg cggagggcga agcatgtaac ttaatttgca   1680

gacatttttt ttccccataa gcctgaagga atcatcacat aagcttatta aatacaagct   1740

attgaaagat ataatggagg atgaatttgg cattagtagg cattttact               1789


<210>  132
<211>  309
<212>  PRT
<213>  Homosapiens

<400>  132

Met Ser Ser Gly Leu Arg Ala Ala Asp Phe Pro Arg Trp Lys Arg His 
1               5                   10                  15      


Ile Ser Glu Gln Leu Arg Arg Arg Asp Arg Leu Gln Arg Gln Ala Phe 
            20                  25                  30          


Glu Glu Ile Ile Leu Gln Tyr Asn Lys Leu Leu Glu Lys Ser Asp Leu 
        35                  40                  45              


His Ser Val Leu Ala Gln Lys Leu Gln Ala Glu Lys His Asp Val Pro 
    50                  55                  60                  


Asn Arg His Glu Ile Ser Pro Gly His Asp Gly Thr Trp Asn Asp Asn 
65                  70                  75                  80  


Gln Leu Gln Glu Met Ala Gln Leu Arg Ile Lys His Gln Glu Glu Leu 
                85                  90                  95      


Thr Glu Leu His Lys Lys Arg Gly Glu Leu Ala Gln Leu Val Ile Asp 
            100                 105                 110         


Leu Asn Asn Gln Met Gln Arg Lys Asp Arg Glu Met Gln Lys Glu Leu 
        115                 120                 125             


Ala Glu Ala Ala Lys Glu Pro Leu Pro Val Glu Gln Asp Asp Asp Ile 
    130                 135                 140                 


Glu Val Ile Val Asp Glu Thr Ser Asp His Thr Glu Glu Thr Ser Pro 
145                 150                 155                 160 


Val Arg Ala Ile Ser Arg Ala Ala Thr Lys Arg Leu Ser Gln Pro Ala 
                165                 170                 175     


Gly Gly Leu Leu Asp Ser Ile Thr Asn Ile Phe Gly Arg Arg Ser Val 
            180                 185                 190         


Ser Ser Phe Pro Val Pro Gln Asp Asn Val Asp Thr His Pro Gly Ser 
        195                 200                 205             


Gly Lys Glu Val Arg Val Pro Ala Thr Ala Leu Cys Val Phe Asp Ala 
    210                 215                 220                 


His Asp Gly Glu Val Asn Ala Val Gln Phe Ser Pro Gly Ser Arg Leu 
225                 230                 235                 240 


Leu Ala Thr Gly Gly Met Asp Arg Arg Val Lys Leu Trp Glu Val Phe 
                245                 250                 255     


Gly Glu Lys Cys Glu Phe Lys Gly Ser Leu Ser Gly Ser Asn Ala Gly 
            260                 265                 270         


Ile Thr Ser Ile Glu Phe Asp Ser Ala Gly Ser Tyr Leu Leu Ala Ala 
        275                 280                 285             


Ser Asn Asp Phe Ala Ser Arg Ile Trp Thr Val Asp Asp Tyr Arg Leu 
    290                 295                 300                 


Arg Val Arg Pro Ser 
305                 


<210>  133
<211>  2481
<212>  DNA
<213>  Homosapiens

<400>  133
aagaccgtcc cggatggcct cggggactgc cagtgtgtgg aggtgagctc cgggattgcc     60

ggcattcccg cttctgctgg ttgcttcatg ctgcaggctg cggccgtcag ccctcgctcg    120

cattggtggc gctgaggtgc cggggcagca agtgacatgt cgtcgggcct ccgcgccgct    180

gacttccccc gctggaagcg ccacatctcg gagcaactga ggcgccggga ccggctgcag    240

agacaggcgt tcgaggagat catcctgcag tataacaaat tgctggaaaa gtcagatctt    300

cattcagtgt tggcccagaa actacaggct gaaaagcatg acgtaccaaa caggcacgag    360

ataaggaggc ggcaagcccg gctgcagaaa gagcttgcag aagcagcaaa ggaacctcta    420

ccagtcgaac aggatgatga cattgaggtc attgtggatg aaacttctga tcacacagaa    480

gagacctctc ctgtgcgagc catcagcaga gcagccacta agcgactctc gcagcctgct    540

ggaggccttc tggattctat cactaatatc tttgggagac gctctgtctc ttccttccca    600

gtcccccagg acaatgtgga tactcatcct ggttctggta aagaagtgag ggtaccagct    660

actgccttgt gtgtcttcga tgcacatgat ggggaagtca acgctgtgca gttcagtcca    720

ggaattacaa gcattgaatt tgatagtgct ggatcttacc tcttagcagc ttcaaatgat    780

tttgcaagcc gaatctggac tgtggatgat tatcgattac ggcacacact cacgggacac    840

agtgggaaag tgctgtctgc taagttcctg ctggacaatg cgcggattgt ctcaggaagt    900

cacgaccgga ctctcaaact ctgggatcta cgcagcaaag tctgcataaa gacagtgttt    960

gcaggatcca gttgcaatga tattgtctgc acagagcaat gtgtaatgag tggacatttt   1020

gacaagaaaa ttcgtttctg ggacattcga tcagagagca tagttcgaga gatggagctg   1080

ttgggaaaga ttactgccct ggacttaaac ccagaaagga ctgagctcct gagctgctcc   1140

cgtgatgact tgctaaaagt tattgatctc cgaacaaatg ctatcaagca gacattcagt   1200

gcacctgggt tcaagtgcgg ctctgactgg accagagttg tcttcagccc tgatggcagt   1260

tacgtggcgg caggctctgc tgagggctct ctgtatatct ggagtgtgct cacagggaaa   1320

gtggaaaagg ttctttcaaa gcagcacagc tcatccatca atgcggtggc gtggtcgccc   1380

tctggctcgc acgttgtcag tgtggacaaa ggatgcaaag ctgtgctgtg ggcacagtac   1440

tgacggggct ctcagggctg ggaggacccc agtgccctcc tcagaagaag cacatgggct   1500

cctgcagccc tgtcctggca ggtgatgtgc tgggtatagc atggacctcc cagagaagct   1560

caagctatgt ggcactgtag ctttgccgtg aatgggattt ctgaagattt gactgaggtc   1620

tctcttggcc tggaagaata acactgaaaa aacctgacgc tgcggtcact tagcagaggc   1680

tcaggttctt gccttgggaa acactactag ctctgacctt ccatacctca cttgggggag   1740

cacagggccc cgctgggcct cctcaccaac ggcagtgcca aaatcagccc ccacatcaag   1800

gtggtgttct ctgtgctttc tctcgtcctt ccaaagtcgg ttctggccta acgcatgtcc   1860

caacaccttg ggttcatttg cccggtgaac tcactttaag cattggatta acggaaactc   1920

ccgaactaca gacccctccc tggtgggttg catgaatgtg tctcattact gctgaaatgt   1980

cctcacatct ctttcactgt tcttcagagc tttctggctc tctttccccc acaaaattcg   2040

acatatttaa aaatctccgt gtggctttaa aaaatggttt tttgtttttt tgtttttttg   2100

aggtgggaga ggatgtgtga aaatcttttc cagggaaatg ggttcgctgc agaggtaagg   2160

atgtgttcct gtatcgatct gcagacaccc agaaggtggg tgcacactgc atgcttgggg   2220

gtgccaaggg attcgagacc tccaacatac ttgtctgaag gtggtgattc tggccatggc   2280

ccctctgcca agcctgtgtg cgatgccctt ggtgctttag tgcaagaagc ctaggctcag   2340

aagcacagca gcgccatctt tccgtttcag gggttgtgat gaaggccaag gaaaaacatt   2400

tatctttact atttatttca ttatgttggc caacagaact tgattgtaaa taataataaa   2460

gaaatctgtt atatactttt c                                             2481


<210>  134
<211>  428
<212>  PRT
<213>  Homosapiens

<400>  134

Met Ser Ser Gly Leu Arg Ala Ala Asp Phe Pro Arg Trp Lys Arg His 
1               5                   10                  15      


Ile Ser Glu Gln Leu Arg Arg Arg Asp Arg Leu Gln Arg Gln Ala Phe 
            20                  25                  30          


Glu Glu Ile Ile Leu Gln Tyr Asn Lys Leu Leu Glu Lys Ser Asp Leu 
        35                  40                  45              


His Ser Val Leu Ala Gln Lys Leu Gln Ala Glu Lys His Asp Val Pro 
    50                  55                  60                  


Asn Arg His Glu Ile Arg Arg Arg Gln Ala Arg Leu Gln Lys Glu Leu 
65                  70                  75                  80  


Ala Glu Ala Ala Lys Glu Pro Leu Pro Val Glu Gln Asp Asp Asp Ile 
                85                  90                  95      


Glu Val Ile Val Asp Glu Thr Ser Asp His Thr Glu Glu Thr Ser Pro 
            100                 105                 110         


Val Arg Ala Ile Ser Arg Ala Ala Thr Lys Arg Leu Ser Gln Pro Ala 
        115                 120                 125             


Gly Gly Leu Leu Asp Ser Ile Thr Asn Ile Phe Gly Arg Arg Ser Val 
    130                 135                 140                 


Ser Ser Phe Pro Val Pro Gln Asp Asn Val Asp Thr His Pro Gly Ser 
145                 150                 155                 160 


Gly Lys Glu Val Arg Val Pro Ala Thr Ala Leu Cys Val Phe Asp Ala 
                165                 170                 175     


His Asp Gly Glu Val Asn Ala Val Gln Phe Ser Pro Gly Ile Thr Ser 
            180                 185                 190         


Ile Glu Phe Asp Ser Ala Gly Ser Tyr Leu Leu Ala Ala Ser Asn Asp 
        195                 200                 205             


Phe Ala Ser Arg Ile Trp Thr Val Asp Asp Tyr Arg Leu Arg His Thr 
    210                 215                 220                 


Leu Thr Gly His Ser Gly Lys Val Leu Ser Ala Lys Phe Leu Leu Asp 
225                 230                 235                 240 


Asn Ala Arg Ile Val Ser Gly Ser His Asp Arg Thr Leu Lys Leu Trp 
                245                 250                 255     


Asp Leu Arg Ser Lys Val Cys Ile Lys Thr Val Phe Ala Gly Ser Ser 
            260                 265                 270         


Cys Asn Asp Ile Val Cys Thr Glu Gln Cys Val Met Ser Gly His Phe 
        275                 280                 285             


Asp Lys Lys Ile Arg Phe Trp Asp Ile Arg Ser Glu Ser Ile Val Arg 
    290                 295                 300                 


Glu Met Glu Leu Leu Gly Lys Ile Thr Ala Leu Asp Leu Asn Pro Glu 
305                 310                 315                 320 


Arg Thr Glu Leu Leu Ser Cys Ser Arg Asp Asp Leu Leu Lys Val Ile 
                325                 330                 335     


Asp Leu Arg Thr Asn Ala Ile Lys Gln Thr Phe Ser Ala Pro Gly Phe 
            340                 345                 350         


Lys Cys Gly Ser Asp Trp Thr Arg Val Val Phe Ser Pro Asp Gly Ser 
        355                 360                 365             


Tyr Val Ala Ala Gly Ser Ala Glu Gly Ser Leu Tyr Ile Trp Ser Val 
    370                 375                 380                 


Leu Thr Gly Lys Val Glu Lys Val Leu Ser Lys Gln His Ser Ser Ser 
385                 390                 395                 400 


Ile Asn Ala Val Ala Trp Ser Pro Ser Gly Ser His Val Val Ser Val 
                405                 410                 415     


Asp Lys Gly Cys Lys Ala Val Leu Trp Ala Gln Tyr 
            420                 425             


<210>  135
<211>  2353
<212>  DNA
<213>  Homosapiens

<400>  135
taagcgactc tcgcagcctg ctggaggcct tctggattct atcactaata tctttgggag     60

acgctctgtc tcttccttcc cagtccccca ggacaatgtg gatactcatc ctggttctgg    120

taaagaagtg agggtaccag ctactgcctt gtgtgtcttc gatgcacatg atggggaagt    180

caacgctgtg cagttcagtc caggttcccg gttactggcc actggaggca tggaccgcag    240

ggttaagctt tgggaagtat ttggagaaaa atgtgagttc aagggttccc tatctggcag    300

taatgcagga attacaagca ttgaatttga tagtgctgga tcttacctct tagcagcttc    360

aaatgatttt gcaagccgaa tctggactgt ggatgattat cgattacggc acacactcac    420

gggacacagt gggaaagtgc tgtctgctaa gttcctgctg gacaatgcgc ggattgtctc    480

aggaagtcac gaccggactc tcaaactctg ggatctacgc agcaaagtct gcataaagac    540

agtgtttgca ggatccagtt gcaatgatat tgtctgcaca gagcaatgtg taatgagtgg    600

acattttgac aagaaaattc gtttctggga cattcgatca gagagcatag ttcgagagat    660

ggagctgttg ggaaagatta ctgccctgga cttaaaccca gaaaggactg agctcctgag    720

ctgctcccgt gatgacttgc taaaagttat tgatctccga acaaatgcta tcaagcagac    780

attcagtgca cctgggttca agtgcggctc tgactggacc agagttgtct tcagccctga    840

tggcagttac gtggcggcag gctctgctga gggctctctg tatatctgga gtgtgctcac    900

agggaaagtg gaaaaggttc tttcaaagca gcacagctca tccatcaatg cggtggcgtg    960

gtcgccctct ggctcgcacg ttgtcagtgt ggacaaagga tgcaaagctg tgctgtgggc   1020

acagtactga cggggctctc agggctggga ggaccccagt gccctcctca gaagaagcac   1080

atgggctcct gcagccctgt cctggcaggt gatgtgctgg gtatagcatg gacctcccag   1140

agaagctcaa gctatgtggc actgtagctt tgccgtgaat gggatttctg aagatttgac   1200

tgaggtctct cttggcctgg aagaataaca ctgaaaaaac ctgacgctgc ggtcacttag   1260

cagaggctca ggttcttgcc ttgggaaaca ctactagctc tgaccttcca tacctcactt   1320

gggggagcac agggccccgc tgggcctcct caccaacggc agtgccaaaa tcagccccca   1380

catcaaggtg gtgttctctg tgctttctct cgtccttcca aagtcggttc tggcctaacg   1440

catgtcccaa caccttgggt tcatttgccc ggtgaactca ctttaagcat tggattaacg   1500

gaaactcccg aactacagac ccctccctgg tgggttgcat gaatgtgtct cattactgct   1560

gaaatgtcct cacatctctt tcactgttct tcagagcttt ctggctctct ttcccccaca   1620

aaattcgaca tatttaaaaa tctccgtgtg gctttaaaaa atggtttttt gtttttttgt   1680

ttttttgagg tgggagagga tgtgtgaaaa tcttttccag ggaaatgggt tcgctgcaga   1740

ggtaaggatg tgttcctgta tcgatctgca gacacccaga aggtgggtgc acactgcatg   1800

cttgggggtg ccaagggatt cgagacctcc aacatacttg tctgaaggtg gtgattctgg   1860

ccatggcccc tctgccaagc ctgtgtgcga tgcccttggt gctttagtgc aagaagccta   1920

ggctcagaag cacagcagcg ccatctttcc gtttcagggg ttgtgatgaa ggccaaggaa   1980

aaacatttat ctttactatt ttacctacgt ataaagtttt agttcattgg gtgtgcgaaa   2040

cacccttttt atcactttta aatttgcact ttattttttt tcttccatgc ttgttctctg   2100

gacatttggg gatgtgagtg ttagagctgg tgagagagga gtcaggtggc cttcccaccg   2160

atggtcctgg cctccacctg ccctctcttc cctgcctgat caccgctttc caatttgccc   2220

ttcagagaac ttaagtcaag gagagttgaa attcacaggc cagggcacat cttttattta   2280

tttcattatg ttggccaaca gaacttgatt gtaaataata ataaagaaat ctgttatata   2340

cttttcaaac tcc                                                      2353


<210>  136
<211>  266
<212>  PRT
<213>  Homosapiens

<400>  136

Met Asp Arg Arg Val Lys Leu Trp Glu Val Phe Gly Glu Lys Cys Glu 
1               5                   10                  15      


Phe Lys Gly Ser Leu Ser Gly Ser Asn Ala Gly Ile Thr Ser Ile Glu 
            20                  25                  30          


Phe Asp Ser Ala Gly Ser Tyr Leu Leu Ala Ala Ser Asn Asp Phe Ala 
        35                  40                  45              


Ser Arg Ile Trp Thr Val Asp Asp Tyr Arg Leu Arg His Thr Leu Thr 
    50                  55                  60                  


Gly His Ser Gly Lys Val Leu Ser Ala Lys Phe Leu Leu Asp Asn Ala 
65                  70                  75                  80  


Arg Ile Val Ser Gly Ser His Asp Arg Thr Leu Lys Leu Trp Asp Leu 
                85                  90                  95      


Arg Ser Lys Val Cys Ile Lys Thr Val Phe Ala Gly Ser Ser Cys Asn 
            100                 105                 110         


Asp Ile Val Cys Thr Glu Gln Cys Val Met Ser Gly His Phe Asp Lys 
        115                 120                 125             


Lys Ile Arg Phe Trp Asp Ile Arg Ser Glu Ser Ile Val Arg Glu Met 
    130                 135                 140                 


Glu Leu Leu Gly Lys Ile Thr Ala Leu Asp Leu Asn Pro Glu Arg Thr 
145                 150                 155                 160 


Glu Leu Leu Ser Cys Ser Arg Asp Asp Leu Leu Lys Val Ile Asp Leu 
                165                 170                 175     


Arg Thr Asn Ala Ile Lys Gln Thr Phe Ser Ala Pro Gly Phe Lys Cys 
            180                 185                 190         


Gly Ser Asp Trp Thr Arg Val Val Phe Ser Pro Asp Gly Ser Tyr Val 
        195                 200                 205             


Ala Ala Gly Ser Ala Glu Gly Ser Leu Tyr Ile Trp Ser Val Leu Thr 
    210                 215                 220                 


Gly Lys Val Glu Lys Val Leu Ser Lys Gln His Ser Ser Ser Ile Asn 
225                 230                 235                 240 


Ala Val Ala Trp Ser Pro Ser Gly Ser His Val Val Ser Val Asp Lys 
                245                 250                 255     


Gly Cys Lys Ala Val Leu Trp Ala Gln Tyr 
            260                 265     


<210>  137
<211>  597
<212>  DNA
<213>  Homosapiens

<400>  137
catgtggctg gctgtgggaa gactgttcca ggagaggaaa tagcaagtgg aaaggcctag     60

acggaggttt aaagaaaagc aggccagtgg tggtggctca cgtctgtaac cccaacactt    120

tagaaggttg aggtgagagg atcaggtggt gagaaataaa gtcagaggta aaggggggcc    180

agagcatgcc ggacctggca agcattgtcc agacttaaat gggaagccat tggaatgttt    240

gggtggatgc tgatacccca aacgtcagaa caggctttct gcatatactt gtttcattcc    300

caagtcagtc ccccatgtaa gtgtgttagt ggtcgcagag tcccctccat ccattccctg    360

agtgttcttg ggagcaggca ttgttctggg cactgtgaag acaaaagtga aggaaacaaa    420

atggcctagg ccctgccctc atggagcctg gactccagtg agggaagaga gactgtagaa    480

taattcccaa gcaagagtga aatgtggcca ggcacggtag ctcatgccta taatcccagc    540

acttcaggag gccaggagtt tgacaccaac ctggccaaca tgacgaaacc ccatctc       597


<210>  138
<211>  64
<212>  PRT
<213>  Homosapiens

<400>  138

Met Phe Gly Trp Met Leu Ile Pro Gln Thr Ser Glu Gln Ala Phe Cys 
1               5                   10                  15      


Ile Tyr Leu Phe His Ser Gln Val Ser Pro Pro Cys Lys Cys Val Ser 
            20                  25                  30          


Gly Arg Arg Val Pro Ser Ile His Ser Leu Ser Val Leu Gly Ser Arg 
        35                  40                  45              


His Cys Ser Gly His Cys Glu Asp Lys Ser Glu Gly Asn Lys Met Ala 
    50                  55                  60                  


<210>  139
<211>  2682
<212>  DNA
<213>  Homosapiens

<400>  139
gagacctgga tgctgggcat cctcgctaga tcccctacaa attccccaca tacgtaggcc     60

aggagcctca gcggtgcccc ttcaggctca tctggcaaga cggtaccagc ttgctcagaa    120

caggggctgg ctattcatca tctcagagca tagagaccct ctccttgcca cccggccctt    180

cccacctggt tggtgacaaa tcacaaggtg gtagaagttg ccagggacag ataacatggc    240

agccagcggg aagaccagca agtccgaacc gaaccatgtt atcttcaaga agatctcccg    300

ggacaaatcg gtgaccatct acctggggaa cagagactac atagaccatg tcagccaagt    360

ccagcctgtg gatggtgtcg tgttggttga tcctgatctt gtgaagggaa agaaagtttc    420

ctgactactt gccctgttca gtgatgttgc agccagctcc acaagattca gggaagtcct    480

gtggggttga ctttgaggtc aaagcattcg ccacagacag caccgatgcc gaagaggaca    540

aaatccccaa gaagtaagag tatggttgcg gaataggtga ggggtctgcg gtgggggtgg    600

agagaagaga cgacctccac cttgtctctg tgggacagac ctcttcccat agggctggca    660

cggctggggt accatctgca tgtgggatgg aggtcaaagg ttgatcattt ttggggaaaa    720

aaaagaaaac aagaaaatga cagggaagtt agcaacctcc agggctcacg taagccccga    780

aaagctcccg ggtttcccct ttgttgaagt tttgttgttg ttgtttgttt gtttgtttgt    840

ttgttttttg tggtaaaatg tacacaacat gaagtttgcc attttaacca cttttttttc    900

tttttttctt ttattttttg aaatggagcc tcgctctgtc ccccaggctg gagtgcaatg    960

tgacctcggc tcactgcaac ctccgcctcc caggttcaag cgattctcct gcctcaatct   1020

cccgagtagc tgggattaca ggcgtgcgcc accacgcctg gctaattttt ttttttttgt   1080

atttttagta gagatgggtt tcaccatgtt ggccaggctg gtcttgaact cctgacctca   1140

agtgatccgc ccgccttggc ctcccaaagt gctgggatta caggcgtgag ccactgtgcc   1200

cggcccattt taaccacttt taaatgtacc attcagtggc ttaagtacat tccgaatgtt   1260

gtgtagcctt caccgctgtc tatacccaaa actttcccat tgcctgagca ggaactctac   1320

aaccattgag cctaccgctc catccttccc attctcccac cccctgtgct gttttttttt   1380

tacctaaaca agatttccgc ctggcccttc gcactgtctc cttgtgcccc atgtacacat   1440

ctctggaggc gcaggatagt gagctgcagt aatggagctc gcatgtatat ggcagctatt   1500

ccatgaggcc cttgacgccc tcacacctta gccttgctga caggaggcag agctgggaat   1560

ccacggagcc taaggggcta agcttggccc tcgggatgtt gcctggcccc acagcttccc   1620

ccacagggaa gggaccagga cccagacccc caggctcttc caccgtcagg gctgcctcag   1680

gctctgacca gtgtcgttgc cctcttcccg tccaccctgt ctccatgggg agcattcctg   1740

gagaatctcc atgtgacagt ggggagagaa cagaagcctc cctaaagcgg cctgggtgcc   1800

aatccctggc ttgtctgtgg ctgtttccca caggagctcc gtgcgattac tgatccgcaa   1860

agtacagcat gccccacttg agatgggtcc ccagccccga gctgaggcgg cctggcagtt   1920

cttcatgtct gacaagcccc tgcaccttgc ggtctctctc aacaaagaga tctatttcca   1980

tggggagccc atccctgtga ccgtgactgt caccaataac acagagaaga ccgtgaagaa   2040

gattaaagca ttcgtggaac aggtggccaa tgtggttctc tactcgagtg attattacgt   2100

caagcccgtg gctatggagg aagcgcaaga aaaagtgcca ccaaacagca ctttgaccaa   2160

gacgctgacg ctgctgccct tgctggctaa caatcgagaa aggagaggca ttgccctgga   2220

tgggaaaatc aagcacgagg acacaaacct tgcctccagc accatcatta aggagggcat   2280

agaccggacc gtcctgggaa tcctggtgtc ttaccagatc aaggtgaagc tcacagtgtc   2340

aggctttctg ggagagctca cctccagtga agtcgccact gaggtcccat tccgcctcat   2400

gcaccctcag cctgaggacc cagctaagga aagttatcag gatgcaaatt tagtttttga   2460

ggagtttgct cgccataatc tgaaagatgc aggagaagct gaggagggga agagagacaa   2520

gaatgacgtt gatgagtgaa gatgtcggct caggatgccg gaaaatgacc tgtagttacc   2580

agtgcaacga gcaaagcccc acagtttagt cctttggagt tatgctgcgt atgaaaggat   2640

gagtcttctt ccgagaaata aagcttgttt gttctcccct gg                      2682


<210>  140
<211>  218
<212>  PRT
<213>  Homosapiens

<400>  140

Met Gly Pro Gln Pro Arg Ala Glu Ala Ala Trp Gln Phe Phe Met Ser 
1               5                   10                  15      


Asp Lys Pro Leu His Leu Ala Val Ser Leu Asn Lys Glu Ile Tyr Phe 
            20                  25                  30          


His Gly Glu Pro Ile Pro Val Thr Val Thr Val Thr Asn Asn Thr Glu 
        35                  40                  45              


Lys Thr Val Lys Lys Ile Lys Ala Phe Val Glu Gln Val Ala Asn Val 
    50                  55                  60                  


Val Leu Tyr Ser Ser Asp Tyr Tyr Val Lys Pro Val Ala Met Glu Glu 
65                  70                  75                  80  


Ala Gln Glu Lys Val Pro Pro Asn Ser Thr Leu Thr Lys Thr Leu Thr 
                85                  90                  95      


Leu Leu Pro Leu Leu Ala Asn Asn Arg Glu Arg Arg Gly Ile Ala Leu 
            100                 105                 110         


Asp Gly Lys Ile Lys His Glu Asp Thr Asn Leu Ala Ser Ser Thr Ile 
        115                 120                 125             


Ile Lys Glu Gly Ile Asp Arg Thr Val Leu Gly Ile Leu Val Ser Tyr 
    130                 135                 140                 


Gln Ile Lys Val Lys Leu Thr Val Ser Gly Phe Leu Gly Glu Leu Thr 
145                 150                 155                 160 


Ser Ser Glu Val Ala Thr Glu Val Pro Phe Arg Leu Met His Pro Gln 
                165                 170                 175     


Pro Glu Asp Pro Ala Lys Glu Ser Tyr Gln Asp Ala Asn Leu Val Phe 
            180                 185                 190         


Glu Glu Phe Ala Arg His Asn Leu Lys Asp Ala Gly Glu Ala Glu Glu 
        195                 200                 205             


Gly Lys Arg Asp Lys Asn Asp Val Asp Glu 
    210                 215             


<210>  141
<211>  6660
<212>  DNA
<213>  Homosapiens

<400>  141
gagacctgga tgctgggcat cctcgctaga tcccctacaa attccccaca tacgtaggcc     60

aggagcctca gcggtgcccc ttcaggctca tctggcaaga cggtaccagc ttgctcagaa    120

caggggctgg ctattcatca tctcagagca tagagaccct ctccttgcca cccggccctt    180

cccacctggt tggtgacaaa tcacaaggtg gtagaagttg ccagggacag ataacatggc    240

agccagcggg aagaccagca agtccgaacc gaaccatgtt atcttcaaga agatctcccg    300

ggacaaatcg gtgaccatct acctggggaa cagagactac atagaccatg tcagccaagt    360

ccagcctgtg gatggtgtcg tgttggttga tcctgatctt gtgaagggaa agaaagtttc    420

ctgactactt gccctgttca gtgatgttgc agccagctcc acaagattca gggaagtcct    480

gtggggttga ctttgaggtc aaagcattcg ccacagacag caccgatgcc gaagaggaca    540

aaatccccaa gaagtaagag tatggttgcg gaataggtga ggggtctgcg gtgggggtgg    600

agagaagaga cgacctccac cttgtctctg tgggacagac ctcttcccat agggctggca    660

cggctggggt accatctgca tgtgggatgg aggtcaaagg ttgatcattt ttggggaaaa    720

aaaagaaaac aagaaaatga cagggaagtt agcaacctcc agggctcacg taagccccga    780

aaagctcccg ggtttcccct ttgttgaagt tttgttgttg ttgtttgttt gtttgtttgt    840

ttgttttttg tggtaaaatg tacacaacat gaagtttgcc attttaacca cttttttttc    900

tttttttctt ttattttttg aaatggagcc tcgctctgtc ccccaggctg gagtgcaatg    960

tgacctcggc tcactgcaac ctccgcctcc caggttcaag cgattctcct gcctcaatct   1020

cccgagtagc tgggattaca ggcgtgcgcc accacgcctg gctaattttt ttttttttgt   1080

atttttagta gagatgggtt tcaccatgtt ggccaggctg gtcttgaact cctgacctca   1140

agtgatccgc ccgccttggc ctcccaaagt gctgggatta caggcgtgag ccactgtgcc   1200

cggcccattt taaccacttt taaatgtacc attcagtggc ttaagtacat tccgaatgtt   1260

gtgtagcctt caccgctgtc tatacccaaa actttcccat tgcctgagca ggaactctac   1320

aaccattgag cctaccgctc catccttccc attctcccac cccctgtgct gttttttttt   1380

tacctaaaca agatttccgc ctggcccttc gcactgtctc cttgtgcccc atgtacacat   1440

ctctggaggc gcaggatagt gagctgcagt aatggagctc gcatgtatat ggcagctatt   1500

ccatgaggcc cttgacgccc tcacacctta gccttgctga caggaggcag agctgggaat   1560

ccacggagcc taaggggcta agcttggccc tcgggatgtt gcctggcccc acagcttccc   1620

ccacagggaa gggaccagga cccagacccc caggctcttc caccgtcagg gctgcctcag   1680

gctctgacca gtgtcgttgc cctcttcccg tccaccctgt ctccatgggg agcattcctg   1740

gagaatctcc atgtgacagt ggggagagaa cagaagcctc cctaaagcgg cctgggtgcc   1800

aatccctggc ttgtctgtgg ctgtttccca caggagctcc gtgcgattac tgatccgcaa   1860

agtacagcat gccccacttg agatgggtcc ccagccccga gctgaggcgg cctggcagtt   1920

cttcatgtct gacaagcccc tgcaccttgc ggtctctctc aacaaagagg taaccaccta   1980

ccatcgctac tacccgcagg gcagcaggcc taggggcagg ccccacaccc ctctcttcac   2040

cagccccagc ccttaactac atgggtgcct tgcaaggaag cttgtttcta ggataaagca   2100

ccaacatgcg taagtgactg gcctgttttc acagcctgga gctggtcagc atggtcctta   2160

gaggaggacg gaactggctt gcgttccacc cactggctgt cccgagggac tggggaagga   2220

aggggcgctg cttttcacat acctgccccc cagctgtcct tgtcctgtcc acctccatgg   2280

gccttgttca ctcatggagc atcaatagct gtggtatccc aaattcttca cttcctggga   2340

aatttaagtt ttgcagaaac catgtgggat ggcagtgtca cctgtgatgt catctcttag   2400

gggtgtcatg gtgggaaaag gtgagagctg ctggccaagg ctggctctgg ttcctctggt   2460

cagcagtcag ccatttgtgc actgtgtgta tacacgtgtg tgggtgtgcc aggggctgtg   2520

ttacacgggc tctgctgggt gggatgccag cacttggctt tcccagtggt ttcctttcac   2580

ttcactcatc ctgcccccat aacctcctga cccctggcct cctccgatgt gatgatcgga   2640

actctgttcc cctccccagc ttcccacaga tgggtggaat gtgtttcagg cccttcctta   2700

gaagaaatgt attgctatca cttcatcttc cttaaattct gccgctttta ttccagtgaa   2760

agggattgag atgaatctag aaagcagtaa gattaaagac accgccacat ctgttctctt   2820

cttctgacct atctgctgac ttttctagat ctatttccat ggggagccca tccctgtgac   2880

cgtgactgtc accaataaca cagagaagac cgtgaagaag attaaagcat tcgtggaaca   2940

ggtggccaat gtggttctct actcgagtga ttattacgtc aagcccgtgg ctatggagga   3000

agcgcagtga gtagctgttg gggtttccgt ttcctgggcg tctcagcctt ctgtgtcaag   3060

tttctcgccg tttattgctg aagaaggaac tagaatgttc agctagctcg ccagccttcc   3120

acttccttcc tctttctccc ttcgagggct gcacagaaag ttagcatctt agctctgcat   3180

ctaccacacc cctctgtgcc catcttacag gagttctgag gattaatgca agccaaagaa   3240

tgacgcagag gagagaaata aagacagaaa tgtcaccatg ggatcagctg gctttttcta   3300

tttatccttg gaatgaattg ttaggaattt ggtactattt ccacctccca gaagatggtc   3360

aaatgaactg tcagcccagg ctaggattcc ctatcttttg atctcaaatt gaaatcttat   3420

accagtgaca actggattag aatatatctg ttcttagcct gttgttgtga atgacttttc   3480

ccctttgtta gaatcaaaaa caaatgagaa tcctgccatg gttcctttat gctggcctga   3540

gagacctgcc cagctttgct gtgtgccaca aagtcaaata gattcattta atacatggct   3600

tggagtgggg ggcgatgatc tcccacctcc agccccccga gaggatagct cgaccaggtc   3660

ttaactcttt gccttgctgg catgttctaa gcaccgttgt atgtaaaaaa tattatcagg   3720

gttagaggaa ggttagggta ggggaatgat gaaagacaac tgattcctta agataatata   3780

aggtaataga tagatttttt tgagatggag tctcactctg ttgcccaggc tggagtgcag   3840

tggtgagatc tcagctcact gcaacctcca ccacccaggt tcgagccatt ctcctgactc   3900

agtctcccaa gtagctggaa ttacaggagc ccgccaccaa gcccagctaa ttttgtattt   3960

tttttttttt ttgagacgga gttttgctct tgttgcccaa gcaggagtgc aatggcgcga   4020

tcttgactca ctgcaacctt tgcctcctgg gttcaagtga ttctcctgcc tcagcctcct   4080

gagtagctgg gattacaggc acacgccacc acccctggct aattttttgt atttttatta   4140

gaaatggggt ttcaccatgt tagccaggct ggtctcgaac tcctgacctc aggtgatctg   4200

cccacctcgg cctcccaaag tgctgggatt acaggagtga gccaccgtgc ctggctgatt   4260

ttgtattttt agtagagaca gggtttcacc tgttggccag gctggtctca aactcctgac   4320

ctcaggtgat ctgcttgcct cagcctccca aagtgctgaa attacaggcg tgagccaccg   4380

cacctggcct atatgggaat atttaaaagg caactttagg agaaactatt actgttattc   4440

aaaacagatt caaactgtag gtctacaagg gagggagaca ggaaagaacc accactcact   4500

gcctcctttc tgccaagatt gggctctgtt ctgcctttag gggatcctcg cacatccctg   4560

tgccctggag gggtcttggc cctggttcac ctttcctcat gtgctcagca acatgggagc   4620

aaaggatcct ggctgagttt tcccctaata tgtattccat cacctggtcc tctttcaaag   4680

tgttgggtgc attttgggtc aaagattccc aggaaactgg aaagcattcc aaagtccccc   4740

aaaggctgga ggagcctggg agctggactg gaccatgctg acaagtctga agctagaggc   4800

cactcagaaa gctgcagagc aggagccatc gtcccagagc cctgtggctt ctggggcttt   4860

agtgggcagg cttccacgga accaggacag acctgactcc caagctgctc cccaccatcc   4920

aaacccacat cctgaagctc tggggagtgg ccccagagcc ttggcatagt cctttggcaa   4980

gctctgcaca aacacaaaaa gtccatcctc tgagcccaac cccaagggcc ctcttcctat   5040

tccagccatc tttacaatgc tgtttctgct tttttcaatg ctcaaattac gctcattaag   5100

agaggttcca ccaggaccca gatggtagga tgtgggccac cttgggctct ggcagatttc   5160

tgtaaagagc ttcctgtaga cactggaggc aggatagggg acagctgctt ttacctatcc   5220

agggaaactt gattagggaa aggaagtcct ttcccagaga ggcagttcag acttccagct   5280

gtctcaggac agccttagaa tggtcctgat gctggccaca ccccaccttg ttctggctag   5340

gcacaggatg gagggtgtgc ttccggcacg aatgggctct gctgtcagag agtgtgcagc   5400

cacgtgactg tgggcacact tcccgtctgg aaaatgggga tcttggagca cctgcttggt   5460

atggggttga tgagggtaag gtgagagttt tgaggacagg ccttagcact tggcctggca   5520

cacagcatgc acgtgagtgg aggagccaac tctccagccg cagaggctgc ttcatgatcc   5580

tggccatgct gccgtgtgtc tgcctggaga aacacacatt gctgtgtccc cagctggatc   5640

ccagacccgc ctgttggcac agggtctccg ccatctgtca gatgttgaga aatctatacc   5700

ccgactgatg atgaagaaga tccagtagag aaagagcatg tgctgctttg gacccaagct   5760

attcggtctg tgtgatccac aaattgtggg tccctgcgtt gcccctctag acaacttacc   5820

acacagtcac actgtgaccc ccttatagtg acagtttttg gtgacaagag gctttctggc   5880

ctggactcgt tgctgacacc aaccagaagg ttctgcaggc caccgtgtgg ttcacaaagt   5940

ctcaggagga ggctgtggtc tctgactctt gagccagttt gtctcattaa ctccatagaa   6000

cattctagaa attcagcaat tcagaatagg ctgagttgct tgaagaaata tcctcctgtt   6060

gctgccagcc caccctgaga tttcacaagc actgttctgc ttctcagaaa aagtgccacc   6120

aaacagcact ttgaccaaga cgctgacgct gctgcccttg ctggctaaca atcgagaaag   6180

gagaggcatt gccctggatg ggaaaatcaa gcacgaggac acaaaccttg cctccagcac   6240

catcattaag gagggcatag accggaccgt cctgggaatc ctggtgtctt accagatcaa   6300

ggtgaagctc acagtgtcag gctttctggg agagctcacc tccagtgaag tcgccactga   6360

ggtcccattc cgcctcatgc accctcagcc tgaggaccca gctaaggaaa gttatcagga   6420

tgcaaattta gtttttgagg agtttgctcg ccataatctg aaagatgcag gagaagctga   6480

ggaggggaag agagacaaga atgacgttga tgagtgaaga tgtcggctca ggatgccgga   6540

aaatgacctg tagttaccag tgcaacgagc aaagccccac agtttagtcc tttggagtta   6600

tgctgcgtat gaaaggatga gtcttcttcc gagaaataaa gcttgtttgt tctcccctgg   6660


<210>  142
<211>  62
<212>  PRT
<213>  Homosapiens

<400>  142

Met Ala Ala Ser Gly Lys Thr Ser Lys Ser Glu Pro Asn His Val Ile 
1               5                   10                  15      


Phe Lys Lys Ile Ser Arg Asp Lys Ser Val Thr Ile Tyr Leu Gly Asn 
            20                  25                  30          


Arg Asp Tyr Ile Asp His Val Ser Gln Val Gln Pro Val Asp Gly Val 
        35                  40                  45              


Val Leu Val Asp Pro Asp Leu Val Lys Gly Lys Lys Val Ser 
    50                  55                  60          


<210>  143
<211>  3456
<212>  DNA
<213>  Homosapiens

<400>  143
gagacctgga tgctgggcat cctcgctaga tcccctacaa attccccaca tacgtaggcc     60

aggagcctca gcggtgcccc ttcaggctca tctggcaaga cggtaccagc ttgctcagaa    120

caggggctgg ctattcatca tctcagagca tagagaccct ctccttgcca cccggccctt    180

cccacctggt tggtgacaaa tcacaaggtg gtagaagttg ccagggacag ataacatggc    240

agccagcggg aagaccagca agtccgaacc gaaccatgtt atcttcaaga agatctcccg    300

ggacaaatcg gtgaccatct acctggggaa cagagactac atagaccatg tcagccaagt    360

ccagcctgtg gatggtgtcg tgttggttga tcctgatctt gtgaagggaa agaaagtgta    420

tgtcactctg acctgcgcct tccgctatgg ccaagaggac attgacgtga tcggcttgac    480

cttccgcagg gacctgtact tctcccgggt ccaggtgtat cctcctgtgg gggccgcgag    540

cacccccaca aaactgcaag agagcctgct taaaaagctg gggagcaaca cgtacccctt    600

tctcctgacg tttcctgact acttgccctg ttcagtgatg ttgcagccag ctccacaaga    660

ttcagggaag tcctgtgggg ttgactttga ggtcaaagca ttcgccacag acagcaccga    720

tgccgaagag gacaaaatcc ccaagaagta agagtatggt tgcggaatag gtgaggggtc    780

tgcggtgggg gtggagagaa gagacgacct ccaccttgtc tctgtgggac agacctcttc    840

ccatagggct ggcacggctg gggtaccatc tgcatgtggg atggaggtca aaggttgatc    900

atttttgggg aaaaaaaaga aaacaagaaa atgacaggga agttagcaac ctccagggct    960

cacgtaagcc ccgaaaagct cccgggtttc ccctttgttg aagttttgtt gttgttgttt   1020

gtttgtttgt ttgtttgttt tttgtggtaa aatgtacaca acatgaagtt tgccatttta   1080

accacttttt tttctttttt tcttttattt tttgaaatgg agcctcgctc tgtcccccag   1140

gctggagtgc aatgtgacct cggctcactg caacctccgc ctcccaggtt caagcgattc   1200

tcctgcctca atctcccgag tagctgggat tacaggcgtg cgccaccacg cctggctaat   1260

tttttttttt ttgtattttt agtagagatg ggtttcacca tgttggccag gctggtcttg   1320

aactcctgac ctcaagtgat ccgcccgcct tggcctccca aagtgctggg attacaggcg   1380

tgagccactg tgcccggccc attttaacca cttttaaatg taccattcag tggcttaagt   1440

acattccgaa tgttgtgtag ccttcaccgc tgtctatacc caaaactttc ccattgcctg   1500

agcaggaact ctacaaccat tgagcctacc gctccatcct tcccattctc ccaccccctg   1560

tgctgttttt tttttaccta aacaagattt ccgcctggcc cttcgcactg tctccttgtg   1620

ccccatgtac acatctctgg aggcgcagga tagtgagctg cagtaatgga gctcgcatgt   1680

atatggcagc tattccatga ggcccttgac gccctcacac cttagccttg ctgacaggag   1740

gcagagctgg gaatccacgg agcctaaggg gctaagcttg gccctcggga tgttgcctgg   1800

ccccacagct tcccccacag ggaagggacc aggacccaga cccccaggct cttccaccgt   1860

cagggctgcc tcaggctctg accagtgtcg ttgccctctt cccgtccacc ctgtctccat   1920

ggggagcatt cctggagaat ctccatgtga cagtggggag agaacagaag cctccctaaa   1980

gcggcctggg tgccaatccc tggcttgtct gtggctgttt cccacaggag ctccgtgcga   2040

ttactgatcc gcaaagtaca gcatgcccca cttgagatgg gtccccagcc ccgagctgag   2100

gcggcctggc agttcttcat gtctgacaag cccctgcacc ttgcggtctc tctcaacaaa   2160

gagatctatt tccatgggga gcccatccct gtgaccgtga ctgtcaccaa taacacagag   2220

aagaccgtga agaagattaa agcattcgtg gaacaggtgg ccaatgtggt tctctactcg   2280

agtgattatt acgtcaagcc cgtggctatg gaggaagcgc acatgcacgt gagtggagga   2340

gccaactctc cagccgcaga ggctgcttca tgatcctggc catgctgccg tgtgtctgcc   2400

tggagaaaca cacattgctg tgtccccagc tggatcccag acccgcctgt tggcacaggg   2460

tctccgccat ctgtcagatg ttgagaaatc tataccccga ctgatgatga agaagatcca   2520

gtagagaaag agcatgtgct gctttggacc caagctattc ggtctgtgtg atccacaaat   2580

tgtgggtccc tgcgttgccc ctctagacaa cttaccacac agtcacactg tgaccccctt   2640

atagtgacag tttttggtga caagaggctt tctggcctgg actcgttgct gacaccaacc   2700

agaaggttct gcaggccacc gtgtggttca caaagtctca ggaggaggct gtggtctctg   2760

actcttgagc cagtttgtct cattaactcc atagaacatt ctagaaattc agcaattcag   2820

aataggctga gttgcttgaa gaaatatcct cctgttgctg ccagcccacc ctgagatttc   2880

acaagcactg ttctgcttct cagaaaaagt gccaccaaac agcactttga ccaagacgct   2940

gacgctgctg cccttgctgg ctaacaatcg agaaaggaga ggcattgccc tggatgggaa   3000

aatcaagcac gaggacacaa accttgcctc cagcaccatc attaaggagg gcatagaccg   3060

gaccgtcctg ggaatcctgg tgtcttacca gatcaaggtg aagctcacag tgtcaggctt   3120

tctgggagag ctcacctcca gtgaagtcgc cactgaggtc ccattccgcc tcatgcaccc   3180

tcagcctgag gacccagcta aggaaagtta tcaggatgca aatttagttt ttgaggagtt   3240

tgctcgccat aatctgaaag atgcaggaga agctgaggag gggaagagag acaagaatga   3300

cgttgatgag tgaagatgtc ggctcaggat gccggaaaat gacctgtagt taccagtgca   3360

acgagcaaag ccccacagtt tagtcctttg gagttatgct gcgtatgaaa ggatgagtct   3420

tcttccgaga aataaagctt gtttgttctc ccctgg                             3456


<210>  144
<211>  171
<212>  PRT
<213>  Homosapiens

<400>  144

Met Ala Ala Ser Gly Lys Thr Ser Lys Ser Glu Pro Asn His Val Ile 
1               5                   10                  15      


Phe Lys Lys Ile Ser Arg Asp Lys Ser Val Thr Ile Tyr Leu Gly Asn 
            20                  25                  30          


Arg Asp Tyr Ile Asp His Val Ser Gln Val Gln Pro Val Asp Gly Val 
        35                  40                  45              


Val Leu Val Asp Pro Asp Leu Val Lys Gly Lys Lys Val Tyr Val Thr 
    50                  55                  60                  


Leu Thr Cys Ala Phe Arg Tyr Gly Gln Glu Asp Ile Asp Val Ile Gly 
65                  70                  75                  80  


Leu Thr Phe Arg Arg Asp Leu Tyr Phe Ser Arg Val Gln Val Tyr Pro 
                85                  90                  95      


Pro Val Gly Ala Ala Ser Thr Pro Thr Lys Leu Gln Glu Ser Leu Leu 
            100                 105                 110         


Lys Lys Leu Gly Ser Asn Thr Tyr Pro Phe Leu Leu Thr Phe Pro Asp 
        115                 120                 125             


Tyr Leu Pro Cys Ser Val Met Leu Gln Pro Ala Pro Gln Asp Ser Gly 
    130                 135                 140                 


Lys Ser Cys Gly Val Asp Phe Glu Val Lys Ala Phe Ala Thr Asp Ser 
145                 150                 155                 160 


Thr Asp Ala Glu Glu Asp Lys Ile Pro Lys Lys 
                165                 170     


<210>  145
<211>  1586
<212>  DNA
<213>  Homosapiens

<400>  145
gagacctgga tgctgggcat cctcgctaga tcccctacaa attccccaca tacgtaggcc     60

aggagcctca gcggtgcccc ttcaggctca tctggcaaga cggtaccagc ttgctcagaa    120

caggggctgg ctattcatca tctcagagca tagagaccct ctccttgcca cccggccctt    180

cccacctggt tggtgacaaa tcacaaggtg gtagaagttg ccagggacag ataacatggc    240

agccagcggg aagaccagca agtccgaacc gaaccatgtt atcttcaaga agatctcccg    300

ggacaaatcg gtgaccatct acctggggaa cagagactac atagaccatg tcagccaagt    360

ccagcctgtg gatggtgtcg tgttggttga tcctgatctt gtgaagggaa agaaagtgta    420

tgtcactctg acctgcgcct tccgctatgg ccaagaggac attgacgtga tcggcttgac    480

cttccgcagg gacctgtact tctcccgggt ccaggtgtat cctcctgtgg gggccgcgag    540

cacccccaca aaactgcaag agagcctgct taaaaagctg gggagcaaca cgtacccctt    600

tctcctgacg tttcctgact acttgccctg ttcagtgatg ttgcagccag ctccacaaga    660

ttcagggaag tcctgtgggg ttgactttga ggtcaaagca ttcgccacag acagcaccga    720

tgccgaagag gacaaaatcc ccaagaagag ctccgtgcga ttactgatcc gcaaagtaca    780

gcatgcccca cttgagatgg gtccccagcc ccgagctgag gcggcctggc agttcttcat    840

gtctgacaag cccctgcacc ttgcggtctc tctcaacaaa gagatctatt tccatgggga    900

gcccatccct gtgaccgtga ctgtcaccaa taacacagag aagaccgtga agaagattaa    960

agcattcgtg gaacaggtgg ccaatgtggt tctctactcg agtgattatt acgtcaagcc   1020

cgtggctatg gaggaagcgc aagaaaaagt gccaccaaac agcactttga ccaagacgct   1080

gacgctgctg cccttgctgg ctaacaatcg agaaaggaga ggcattgccc tggatgggaa   1140

aatcaagcac gaggacacaa accttgcctc cagcaccatc attaaggagg gcatagaccg   1200

gaccgtcctg ggaatcctgg tgtcttacca gatcaaggtg aagctcacag tgtcaggctt   1260

tctgggagag ctcacctcca gtgaagtcgc cactgaggtc ccattccgcc tcatgcaccc   1320

tcagcctgag gacccagtta tcaggatgca aatttagttt ttgaggagtt tgctcgccat   1380

aatctgaaag atgcaggaga agctgaggag gggaagagag acaagaatga cgttgatgag   1440

tgaagatgtc ggctcaggat gccggaaaat gacctgtagt taccagtgca acgagcaaag   1500

ccccacagtt tagtcctttg gagttatgct gcgtatgaaa ggatgagtct tcttccgaga   1560

aataaagctt gtttgttctc ccctgg                                        1586


<210>  146
<211>  373
<212>  PRT
<213>  Homosapiens

<400>  146

Met Ala Ala Ser Gly Lys Thr Ser Lys Ser Glu Pro Asn His Val Ile 
1               5                   10                  15      


Phe Lys Lys Ile Ser Arg Asp Lys Ser Val Thr Ile Tyr Leu Gly Asn 
            20                  25                  30          


Arg Asp Tyr Ile Asp His Val Ser Gln Val Gln Pro Val Asp Gly Val 
        35                  40                  45              


Val Leu Val Asp Pro Asp Leu Val Lys Gly Lys Lys Val Tyr Val Thr 
    50                  55                  60                  


Leu Thr Cys Ala Phe Arg Tyr Gly Gln Glu Asp Ile Asp Val Ile Gly 
65                  70                  75                  80  


Leu Thr Phe Arg Arg Asp Leu Tyr Phe Ser Arg Val Gln Val Tyr Pro 
                85                  90                  95      


Pro Val Gly Ala Ala Ser Thr Pro Thr Lys Leu Gln Glu Ser Leu Leu 
            100                 105                 110         


Lys Lys Leu Gly Ser Asn Thr Tyr Pro Phe Leu Leu Thr Phe Pro Asp 
        115                 120                 125             


Tyr Leu Pro Cys Ser Val Met Leu Gln Pro Ala Pro Gln Asp Ser Gly 
    130                 135                 140                 


Lys Ser Cys Gly Val Asp Phe Glu Val Lys Ala Phe Ala Thr Asp Ser 
145                 150                 155                 160 


Thr Asp Ala Glu Glu Asp Lys Ile Pro Lys Lys Ser Ser Val Arg Leu 
                165                 170                 175     


Leu Ile Arg Lys Val Gln His Ala Pro Leu Glu Met Gly Pro Gln Pro 
            180                 185                 190         


Arg Ala Glu Ala Ala Trp Gln Phe Phe Met Ser Asp Lys Pro Leu His 
        195                 200                 205             


Leu Ala Val Ser Leu Asn Lys Glu Ile Tyr Phe His Gly Glu Pro Ile 
    210                 215                 220                 


Pro Val Thr Val Thr Val Thr Asn Asn Thr Glu Lys Thr Val Lys Lys 
225                 230                 235                 240 


Ile Lys Ala Phe Val Glu Gln Val Ala Asn Val Val Leu Tyr Ser Ser 
                245                 250                 255     


Asp Tyr Tyr Val Lys Pro Val Ala Met Glu Glu Ala Gln Glu Lys Val 
            260                 265                 270         


Pro Pro Asn Ser Thr Leu Thr Lys Thr Leu Thr Leu Leu Pro Leu Leu 
        275                 280                 285             


Ala Asn Asn Arg Glu Arg Arg Gly Ile Ala Leu Asp Gly Lys Ile Lys 
    290                 295                 300                 


His Glu Asp Thr Asn Leu Ala Ser Ser Thr Ile Ile Lys Glu Gly Ile 
305                 310                 315                 320 


Asp Arg Thr Val Leu Gly Ile Leu Val Ser Tyr Gln Ile Lys Val Lys 
                325                 330                 335     


Leu Thr Val Ser Gly Phe Leu Gly Glu Leu Thr Ser Ser Glu Val Ala 
            340                 345                 350         


Thr Glu Val Pro Phe Arg Leu Met His Pro Gln Pro Glu Asp Pro Val 
        355                 360                 365             


Ile Arg Met Gln Ile 
    370             


<210>  147
<211>  620
<212>  DNA
<213>  Homosapiens

<400>  147
ctggatgctg ggcatcctcg ctagatcccc tacaaattcc ccacatacgt aggccaggag     60

cctcagcggt gccccttcag gctcatctgg caagacggta ccagcttgct cagaacaggg    120

gctggctatt catcatctca gagcatagag accctctcct tgccacccgg cccttcccac    180

ctggttggtg acaaatcaca aggtggtaga agttgccagg gacagataac atggcagcca    240

gcgggaagac cagcaagtcc gaaccgaacc atgttatctt caagaagatc tcccgggaca    300

aatcggtgac catctacctg gggaacagag actacataga ccatgtcagc caagtccagc    360

ctgtggatgg tgtcgtgttg gttgatcctg atcttgtgaa gggaaagaaa ggtgagatga    420

agccccttgt ctcaggctgg tttctgggcg gagtggactg ctctctgggc ggctctggga    480

aggggcattt acatggaagg agagacagga aggcagaggc agcgctcttg cacatggaac    540

cagtgccagg cccactgacc cacactcctg tacctaattc acgtgacata ggtcctgttg    600

acaccagagc tcactcgctc                                                620


<210>  148
<211>  129
<212>  PRT
<213>  Homosapiens

<400>  148

Met Ala Ala Ser Gly Lys Thr Ser Lys Ser Glu Pro Asn His Val Ile 
1               5                   10                  15      


Phe Lys Lys Ile Ser Arg Asp Lys Ser Val Thr Ile Tyr Leu Gly Asn 
            20                  25                  30          


Arg Asp Tyr Ile Asp His Val Ser Gln Val Gln Pro Val Asp Gly Val 
        35                  40                  45              


Val Leu Val Asp Pro Asp Leu Val Lys Gly Lys Lys Gly Glu Met Lys 
    50                  55                  60                  


Pro Leu Val Ser Gly Trp Phe Leu Gly Gly Val Asp Cys Ser Leu Gly 
65                  70                  75                  80  


Gly Ser Gly Lys Gly His Leu His Gly Arg Arg Asp Arg Lys Ala Glu 
                85                  90                  95      


Ala Ala Leu Leu His Met Glu Pro Val Pro Gly Pro Leu Thr His Thr 
            100                 105                 110         


Pro Val Pro Asn Ser Arg Asp Ile Gly Pro Val Asp Thr Arg Ala His 
        115                 120                 125             


Ser 
    


<210>  149
<211>  440
<212>  DNA
<213>  Homosapiens

<400>  149
gctagatccc ctacaaattc cccacatacg taggccagga gcctcagcgg tgccccttca     60

ggctcatctg gcaagacggt accagcttgc tcagaacagg ggctggctat tcatcatctc    120

agcctgctta aaaagctggg gagcaacacg tacccctttc tcctgacgtt tcctgactac    180

ttgccctgtt cagtgatgtt gcagccagct ccacaagatt cagggaagtc ctgtggggtt    240

gactttgagg tcaaagcatt cgccacagac agcaccgatg ccgaagagga caaaatcccc    300

aagaagtaag agtatggttg cggaataggt gaggggtctg cggtgggggt ggagagaaga    360

gacgacctcc accttgtctc tgtgggacag acctcttccc atagggctgg cacggctggg    420

gtaccatctg catgtgggat                                                440


<210>  150
<211>  37
<212>  PRT
<213>  Homosapiens

<400>  150

Met Leu Gln Pro Ala Pro Gln Asp Ser Gly Lys Ser Cys Gly Val Asp 
1               5                   10                  15      


Phe Glu Val Lys Ala Phe Ala Thr Asp Ser Thr Asp Ala Glu Glu Asp 
            20                  25                  30          


Lys Ile Pro Lys Lys 
        35          


<210>  151
<211>  5083
<212>  DNA
<213>  Homosapiens

<400>  151
gtgctgggat tacaggcgtg agccactgtg cccggcccat tttaaccact tttaaatgta     60

ccattcagtg gcttaagtac attccgaatg ttgtgtagcc ttcaccgctg tctataccca    120

aaactttccc attgcctgag caggaactct acaaccattg agcctaccgc tccatccttc    180

ccattctccc accccctgtg ctgttttttt tttacctaaa caagatttcc gcctggccct    240

tcgcactgtc tccttgtgcc ccatgtacac atctctggag gcgcaggata gtgagctgca    300

gtaatggagc tcgcatgtat atggcagcta ttccatgagg cccttgacgc cctcacacct    360

tagccttgct gacaggaggc agagctggga atccacggag cctaaggggc taagcttggc    420

cctcgggatg ttgcctggcc ccacagcttc ccccacaggg aagggaccag gacccagacc    480

cccaggctct tccaccgtca gggctgcctc aggctctgac cagtgtcgtt gccctcttcc    540

cgtccaccct gtctccatgg ggagcattcc tggagaatct ccatgtgaca gtggggagag    600

aacagaagcc tccctaaagc ggcctgggtg ccaatccctg gcttgtctgt ggctgtttcc    660

cacaggagct ccgtgcgatt actgatccgc aaagtacagc atgccccact tgagatgggt    720

ccccagcccc gagctgaggc ggcctggcag ttcttcatgt ctgacaagcc cctgcacctt    780

gcggtctctc tcaacaaaga gatctatttc catggggagc ccatccctgt gaccgtgact    840

gtcaccaata acacagagaa gaccgtgaag aagattaaag cattcgtgga acaggtggcc    900

aatgtggttc tctactcgag tgattattac gtcaagcccg tggctatgga ggaagcgcaa    960

gaaaaagtgc caccaaacag cactttgacc aagacgctga cgctgctgcc cttgctggct   1020

aacaatcgag aaaggagagg cattgccctg gatgggaaaa tcaagcacga ggacacaaac   1080

cttgcctcca gcaccatcat taaggagggc atagaccgga ccgtcctggg aatcctggtg   1140

tcttaccaga tcaaggtgaa gctcacagtg tcaggctttc tgggagagct cacctccagt   1200

gaagtcgcca ctgaggtccc attccgcctc atgcaccctc agcctgagga cccaggtcag   1260

ttatgtcctt ttttagcttt ctttaattat ttgctacttg cagatttatt gttgatgtat   1320

ttctagtctt tcttgaccgc atctcagagc atgggagtgg ccaggtgtaa gagattccat   1380

gtgatctaca aggtgaatag tctgggggga agggagggcc catctgttca gcgctgagcc   1440

gggtagatta tccaccttca gctggagtct gcaagatgta gcatccttgc tcttggacag   1500

ggacaatctc gtgaggtttt atcatgaatg atttaagagc agaagctctg ctgtcaacag   1560

acctggattt agaattaaag atgatttagg taaaaactta attttagagc acgaggattt   1620

tgcatttcat ttggaaacaa aaggcctcat gtttcatttg aaagcattaa cagacattta   1680

aaagaagata attttttttt ttttttgaga cggagtctca ctctgtcacc cagtctggag   1740

tgcagtggtg tgatcaagct tactacagcc tcaacctcct gggctcaacc caccctccta   1800

cctcagcttc tgaagtagct ggaactacag gcataccacc acccttagct aatgtttttg   1860

atttttagta gagatgaggt cttgccatgt tgctcaggct agtcttgaac tcctgagctc   1920

aagtgatctt tctgcctcat cctcccaaag tgctggggtt acaggcatga gccactgcac   1980

ctggctgaag ataactgttt ttttttgggg tttttttttt tttttttttt ttctgagatg   2040

gagtctctgt cacccagctg gagtgcagtg gcacaacctc ggctcactgc aacctctgcc   2100

tcccgggttc aagtgattct cgtgcctcag cctcctgaat agctgggatt acaggcgcct   2160

gccaccccac ctggctaatt tttgtatttg tagtagagac ggggtttcgc catgtcggcc   2220

aggctagttt tgaactcctg acctcaggtg atccacccgc ctcagcgtcc caaagtgctg   2280

ggattacagg cgtgagtcac ggcgcccggc ctgaagataa ctatttttga cagtggcagt   2340

tatggtaaga atacagaaaa tactagaaaa gagggtcagg ctgggttcct gacacctcag   2400

ctcatttgaa ttataaatct actggctctt gtatggatgc gaaatgatgc aatagttgta   2460

tgactctgaa aacatataaa aaccactaga ctgtcgactg tgaaaaggta aattgtatga   2520

tatatgaatt tgatctcaat cattctcttt ctaaaaaggt aaatgaagca gcaaaaataa   2580

tataggtgaa atctcagaaa ttctgaagaa acattctctg catcgaggca gcttagttga   2640

cgggaaagaa aaacagatct gtctaaatga gaactctccg taggtatagg aataagggat   2700

attttaagta aaagtggtat aaacaagcag ggtttatttt tctcatactt tacaaatagc   2760

ttttctatat tggtagtgaa atgccgttta aacattagaa tgagccccca ctattcattt   2820

taggttttgt ctcaacagta ctttgtttca aaatagctct tccaaatact ttggattcag   2880

atcctcaatg aacttttcca aaactgtccc ttggagaaaa atgtagtcca gctatatgtt   2940

ttcagttcat ttatgcttgt gtcattaaaa tgttactttt tcatggtgtg ggattaagat   3000

gctttctggt tcctttcaag gacattaaaa agatagtcac ttgaggagat gtcatagttt   3060

atgttgggtt gttttctgga actttgagta gactttatgc cttaattttt tttttttgag   3120

acatagtctt attctgtcac ccaggctgga gtgcagtggc atgatctcgg ttcactgcaa   3180

cctccgcctc ccgagttcaa gtgattctcc tgtctcaacc tcccaagtag ctgggattac   3240

tggcacgcgc cagcacgcct ggctaatttt tgtattttta gtagagatgg gttttcacca   3300

tgttggccag gctggtctca aactcctggc ctcaggtgat ctgcccgcct cagccctcca   3360

aagtgctggg attacaggcg tgagccaccg tgcccggcct gacttaattt ttttaaattc   3420

ttttccatat acaactttca cgttccagtc attatggcct taacagtgaa catatcacaa   3480

tgtcaggatg aaacaatgat cttttgtact gtgagatttc tgggagcaaa ggttaagaca   3540

aatcacccca tggttacaaa attctgattt ctagagatat gagatagata tgagatagat   3600

gagatttcta gagataaatg tcatctctcc tgtcttctct gcctagttct cggctccctg   3660

agtctaggct ggtaggattc taagcagaga aagcataagc tatatgtagt taagccctgc   3720

tggagcctgg ggaccaagta atttgtgtgt aataagtgct gtgacatgct accaagtttt   3780

tattgtcccc tgtcaagggc atctttactg aatccgaaga tgctgatttg attcttcctt   3840

gttgtctacc tctgcaaggc tgatggtccc gcttagtgta atttcttcgc tgagcactgt   3900

gggccgcagg gtatttcttg ctcaggggat gttttgacaa gctagcctct ctagggcccc   3960

tgtacgtagc gaccctcata gacactccct cccagtgctg gcttccaggt gggcaccaga   4020

ggcgagagta ggggctcacc atcaaatcgc cgctgtgctc cccaaaacta ggtgggcaga   4080

aagctaaaaa agtacaaaaa ccattcaaat taatagcagt tagtctgggg atacaacaca   4140

tgtgaaaaca taactcaaca acaacaaaat caatatgtta acagaaattg aaaactttgc   4200

ggctgggggt tggtcctcaa gctttaatgc acactctaac cctggggtgc tggtgaacgt   4260

caagtcccag gtctcaggcc tctgaagcct gacagatgga ggtgccaggg tgcacatgct   4320

cacggcaccc tggcgaccct gacctcaatg gggtcccgag gacatggaag gagaaatact   4380

ttgaaaggcg aagcaactgg ctgggcaggg aggccaaggc gggcggaaca cttgaggtca   4440

ggagttcgag accagcctgg ccaacacggt gacaccccgt ctctactaaa aatacaaaaa   4500

ttagccaggc atggtggtgg gtgcctgtaa tcccagctac ttgggaggtt aagccaggag   4560

aatcacttga acctgggaga cggaggttgc agtgagccga gattgtgcca cttcactcca   4620

gcctgggcaa cagagcaaga tgccatctca aataaataaa taagaaagga gaagcgacat   4680

cagagggggc aaggctgatc agggaaagca tcctagagtt gagactgggg gggtttcatg   4740

tgaggaggtg aaggctgtgg cacattgtaa aggaagcagt gatttaaaat gcaaggagag   4800

gccgggcgca gtggctcacg cctgtaatcc cagcacttgg gaggctgagg ctggcagatc   4860

acttgaggtc aggagtttga gaccagcctg gccaacatag ttgaaacccc ttctctacta   4920

cagatacaaa aattagccag gcataatggc gcatgcctgt aatcccagct acttgggagc   4980

ctgagacacg agaaactctt gaaaccagga ggcaaaggtt gcagtgagca gagattgtgg   5040

cactgcattc cagcctgggt gacagagaga gacagtctca aat                     5083


<210>  152
<211>  203
<212>  PRT
<213>  Homosapiens

<400>  152

Met Gly Pro Gln Pro Arg Ala Glu Ala Ala Trp Gln Phe Phe Met Ser 
1               5                   10                  15      


Asp Lys Pro Leu His Leu Ala Val Ser Leu Asn Lys Glu Ile Tyr Phe 
            20                  25                  30          


His Gly Glu Pro Ile Pro Val Thr Val Thr Val Thr Asn Asn Thr Glu 
        35                  40                  45              


Lys Thr Val Lys Lys Ile Lys Ala Phe Val Glu Gln Val Ala Asn Val 
    50                  55                  60                  


Val Leu Tyr Ser Ser Asp Tyr Tyr Val Lys Pro Val Ala Met Glu Glu 
65                  70                  75                  80  


Ala Gln Glu Lys Val Pro Pro Asn Ser Thr Leu Thr Lys Thr Leu Thr 
                85                  90                  95      


Leu Leu Pro Leu Leu Ala Asn Asn Arg Glu Arg Arg Gly Ile Ala Leu 
            100                 105                 110         


Asp Gly Lys Ile Lys His Glu Asp Thr Asn Leu Ala Ser Ser Thr Ile 
        115                 120                 125             


Ile Lys Glu Gly Ile Asp Arg Thr Val Leu Gly Ile Leu Val Ser Tyr 
    130                 135                 140                 


Gln Ile Lys Val Lys Leu Thr Val Ser Gly Phe Leu Gly Glu Leu Thr 
145                 150                 155                 160 


Ser Ser Glu Val Ala Thr Glu Val Pro Phe Arg Leu Met His Pro Gln 
                165                 170                 175     


Pro Glu Asp Pro Gly Gln Leu Cys Pro Phe Leu Ala Phe Phe Asn Tyr 
            180                 185                 190         


Leu Leu Leu Ala Asp Leu Leu Leu Met Tyr Phe 
        195                 200             


<210>  153
<211>  1026
<212>  DNA
<213>  Homosapiens

<400>  153
cttgagccca ggaggtcgag gctacagtga cctatgatca tgccattgca ttccagccta     60

ggtgataaaa tgagaccctg tctcaaaaaa aaaaaaaagt caatcccagc aaagaggggg    120

atctcaagct tgtacccctt ttttcccttt ggaggtatcc tctcttcacc aggtacttgg    180

ccatactccg caagtccaga taaagatatt ctgtcctctt ttaaaaatta tttttatttt    240

tttttgagat aaggtctcag tctgtcaccc aggctggagt gcagtagcgc gttcttggct    300

cactgcaacc tccacctccc aagttcaagg gattctcctg gctcagcctc ctgagtagct    360

gggattagag gctcccacca ccacgcctgg ctaattttgt actttcaata gagatggggt    420

ttcgccatgt tgtccaggct ggtcttgaat ttcctgaact caagcgatct gcccgcctcc    480

gtctcccaaa gtgctgggat taaaggtgtg agccacgacg tctggctatt ctgtcctctt    540

ttaaatgagc tccagacgcc agtgagctga aggagctctc tggggagcac tgtggtcctg    600

gaaacacgtg cttgagacac ctcccctcag aggttcccga gctgacgtct tcttccaggc    660

ccagcacctg ctggccgccg ccccaactct ttttccagag ctgttccatc cttccctgcc    720

ttctgcctgt agccttcagg tttcttgggc tttttttcta tcattattta catgattttt    780

gttagatgca aatttagttt ttgaggagtt tgctcgccat aatctgaaag atgcaggaga    840

agctgaggag gggaagagag acaagaatga cgttgatgag tgaagatgtc ggctcaggat    900

gccggaaaat gacctgtagt taccagtgca acgagcaaag ccccacagtt tagtcctttg    960

gagttatgct gcgtatgaaa ggatgagtct tcttccgaga aataaagctt gtttgttctc   1020

ccctgg                                                              1026


<210>  154
<211>  72
<212>  PRT
<213>  Homosapiens

<400>  154

Met Ile Met Pro Leu His Ser Ser Leu Gly Asp Lys Met Arg Pro Cys 
1               5                   10                  15      


Leu Lys Lys Lys Lys Lys Ser Ile Pro Ala Lys Arg Gly Ile Ser Ser 
            20                  25                  30          


Leu Tyr Pro Phe Phe Pro Phe Gly Gly Ile Leu Ser Ser Pro Gly Thr 
        35                  40                  45              


Trp Pro Tyr Ser Ala Ser Pro Asp Lys Asp Ile Leu Ser Ser Phe Lys 
    50                  55                  60                  


Asn Tyr Phe Tyr Phe Phe Leu Arg 
65                  70          


<210>  155
<211>  1032
<212>  DNA
<213>  Homosapiens

<400>  155
gccaggtctg atgctgggtg ctggggacac acagctggat atcttggaag gcaggagaga     60

aggagggggc attctggtgc agggttgtgt tggcaagact ggcgcggggg gcgctgggac    120

acagctgggg gtgaagtagc aaaggcaggc cagggcagct cacaggctgc ttctgaggct    180

gaacctgcag atggccacag agctcagaga aggggcctgg cacgtgggag atgagttact    240

gagataatcc aggcaggcaa agcctgctgg aggacttggg gacttgcagt tttggcaagt    300

ggtaggaggg agttgctgag gaggatgacc gggggatgtg catctataga ggtcaagcac    360

agagaagggg gttgcatgct ctgccctctg ggaacttcta gaggagaaga cacaggaatt    420

cctccagtgc gtgcaaggag tccccatacc cactccccaa gtacatgaac ttctaggact    480

ttggaagctc agtgagttca ccagtccctg gagaacctcc atgacggcat gcctgcctcg    540

aatggaaagg ctgcccatct gctcttcacc ctcctctgct ctccatcatt ctccttttcc    600

cttctgtttg ggcagcatta aggagggcat agaccggacc gtcctgggaa tcctggtgtc    660

ttaccagatc aaggtgaagc tcacagtgtc aggctttctg ggagagctca cctccagtga    720

agtcgccact gaggtcccat tccgcctcat gcaccctcag cctgaggacc cagctaagga    780

aagttatcag gatgcaaatt tagtttttga ggagtttgct cgccataatc tgaaagatgc    840

aggagaagct gaggagggga agagagacaa gaatgacgtt gatgagtgaa gatgtcggct    900

caggatgccg gaaaatgacc tgtagttacc agtgcaacga gcaaagcccc acagtttagt    960

cctttggagt tatgctgcgt atgaaaggat gagtcttctt ccgagaaata aagcttgttt   1020

gttctcccct gg                                                       1032


<210>  156
<211>  122
<212>  PRT
<213>  Homosapiens

<400>  156

Met Thr Ala Cys Leu Pro Arg Met Glu Arg Leu Pro Ile Cys Ser Ser 
1               5                   10                  15      


Pro Ser Ser Ala Leu His His Ser Pro Phe Pro Phe Cys Leu Gly Ser 
            20                  25                  30          


Ile Lys Glu Gly Ile Asp Arg Thr Val Leu Gly Ile Leu Val Ser Tyr 
        35                  40                  45              


Gln Ile Lys Val Lys Leu Thr Val Ser Gly Phe Leu Gly Glu Leu Thr 
    50                  55                  60                  


Ser Ser Glu Val Ala Thr Glu Val Pro Phe Arg Leu Met His Pro Gln 
65                  70                  75                  80  


Pro Glu Asp Pro Ala Lys Glu Ser Tyr Gln Asp Ala Asn Leu Val Phe 
                85                  90                  95      


Glu Glu Phe Ala Arg His Asn Leu Lys Asp Ala Gly Glu Ala Glu Glu 
            100                 105                 110         


Gly Lys Arg Asp Lys Asn Asp Val Asp Glu 
        115                 120         


<210>  157
<211>  6297
<212>  DNA
<213>  Homosapiens

<400>  157
tggcccggca gcatggcggc ggcggcgggc gcccctccgc cgggtccccc gcaaccgcct     60

ccgccgccgc cgcccgagga gtcgtccgac agcgagcccg aggcggagcc cggctcccca    120

cagaagctca tccgcaaggt gtccacgtcg ggtcagatcc gacagaagac catcatcaaa    180

gaggggatgc tgaccaaaca gaacaattca ttccagcgat caaaaaggag atactttaag    240

cttcgagggc gaacgcttta ctatgccaaa acggcaaagt caatcatatt tgatgaggtg    300

gatctgacag atgccagcgt agctgaatcc agtaccaaaa acgtcaacaa cagttttacg    360

gtcataactc catgcaggaa gctcatcttg tgtgctgata acagaaaaga aatggaagat    420

tggattgcag cattaaagac tgtgcagaac agggagcact ttgagcccac ccagtacagc    480

atggaccact tctcagggat gcacaattgg tacgcctgtt cccacgcgag gccgacctac    540

tgcaatgtgt gccgtgaggc tctgtctggg gtcacgtcgc acgggctgtc ctgcgaggtg    600

tgcaaattta aggcccacaa gcgctgtgct gtgcgtgcaa ccaataactg caagtggacc    660

acactggcct cgatcgggaa ggacatcatt gaagatgcag atgggattgc aatgccccac    720

cagtggttgg aaggaaacct acctgtgagc gccaagtgca ctgtgtgcga caagacctgt    780

ggcagtgtgc tgcgcctgca ggactggcgc tgcctctggt gcaaggccat ggttcacaca    840

tcgtgtaaag aatccttgct gaccaagtgc ccacttggcc tgtgcaaagt gtcagtcatc    900

ccacccacgg ctctcaacag catcgactcc gatgggttct ggaaggccag ctgtcctcct    960

tcttgcacaa gcccactgtt ggtcttcgtc aattcaaaaa gtggggacaa ccagggtgtg   1020

aagttcctca gaagattcaa acagctacta aaccccgccc aggtcttcga cctcatgaac   1080

ggaggcccac acctcggctt acggttattc cagaagtttg acacattccg gattctggtt   1140

tgtggcgggg atggaagtgt tggctgggtc ctctccgaaa tcgacagcct caaccttcat   1200

aaacagtgtc agctgggagt gctgccgctc ggcacaggga acgacttggc ccgagtactg   1260

ggctggggct cagcctgcga tgacgacacc cagctccccc agatcttgga gaagttggag   1320

agagccagca ccaagatgct ggacaggtgg agcgtcatgg catacgaggc caagctcccc   1380

cggcaggcct cctcctctac cgtcaccgaa gacttcagcg aggattccga ggtacagcag   1440

attctcttct atgaagactc ggttgcagcc cacctttcta aaatcctcac ctcggaccag   1500

cactcggtgg tcatctcctc ggccaaagtg ctctgtgaga cggtgaagga cttcgtggca   1560

cgggtgggga aggcctatga gaagacgacc gagagctcgg aggagtcaga ggtcatggcc   1620

aagaagtgct ctgtcctgaa agagaagctg gattcccttc tcaagacctt ggacgatgag   1680

tcccaggcct cgtcctctct gcccaacccg ccccccacca ttgccgagga ggctgaagat   1740

ggagatgggt cgggcagcat ctgcggttcc accggagacc gcttggtggc atcagcttgc   1800

ccggcccggc cgcagatatt ccggcctcga gaacagctca tgctgagagc caacagcctg   1860

aagaaagcaa ttcgtcagat catagaacac acagaaaaag ctgtcgatga gcagaatgcc   1920

cagacccagg agcaggaggg cttcgtcctg ggcctctctg agtcagagga gaagatggac   1980

cacagagtgt gcccaccact gtcccacagc gagagcttcg gggtccccaa ggggaggagc   2040

cagcgcaaag tgtcgaaatc tccgtgtgaa aagctgatca gcaaagggag tctgtcccta   2100

ggcagttctg cttcccttcc gccccagccg ggaagccggg acggcctgcc tgcgctcaac   2160

accaagatcc tgtacccaaa tgtccgggct ggaatgtctg gttccttacc cggtggctca   2220

gtcatcagtc gcctgttaat taatgctgat cccttcaact ctgaaccaga aaccctagag   2280

tattacacgg agaaatgtgt catgaacaac tattttggca ttggcctgga tgcgaagata   2340

tccctggact ttaacaacaa gcgcgatgag cacccagaga agtgcaggag ccgaaccaag   2400

aacatgatgt ggtatggagt tcttggaacc aaagagttgc tgcacagaac ctacaagaac   2460

ctggagcaaa aggtcttgct ggagtgtgac gggcgaccca tcccactccc cagtcttcag   2520

ggaattgctg tccttaacat tcccagctat gccggaggaa ccaacttctg ggggggtacc   2580

aaggaagatg atactttcgc agctccatca ttcgatgaca agattctgga ggtggtcgcc   2640

gtgttcggca gcatgcagat ggccgtctct cgagtcatca ggctacagca tcatcggatc   2700

gcccagtgtc gcacggtgaa gatctccatc cttggggatg agggcgtgcc tgtgcaggtg   2760

gacggagagg cctgggtcca gccgccaggg tacattcgga ttgtccacaa gaaccgggca   2820

cagacactga ccagagacag ggcatttgag agcaccctga agtcctggga agacaagcag   2880

aagtgcgagc tgccccgccc tccatcctgt tccctgcacc cggagatgct gtccgaggag   2940

gaggccaccc agatggacca gtttgggcag gcagcagggg tcctcattca cagtatccga   3000

gaaatagctc agtctcaccg ggacatggag caggaactgg cccacgccgt caatgccagc   3060

tccaagtcca tggaccgtgt gtatggcaag cccagaacca cagaggggct caactgcagc   3120

ttcgtcctgg aaatggtgaa taacttcaga gctctgcgca gtgagacgga gctgctgctg   3180

tctgggaaga tggccctgca gctggatccg cctcagaagg agcagctggg gagtgctctt   3240

gccgagatgg accgacagct caggaggctg gcagacaccc cgtggctctg ccagtccgca   3300

gagcccggcg acgaagagag tgtgatgctg gatcttgcca agcgcagtcg cagtggtaaa   3360

ttccgcctcg tgaccaagtt taaaaaggag aaaaacaaca agaacaaaga agctcacagt   3420

agcctgggag ccccggttca cctctggggg acagaggagg ttgctgcctg gctggagcac   3480

ctcagtctct gtgagtataa ggacatcttc acacggcacg acatccgggg ctctgagctc   3540

ctgcacctgg agcggaggga cctcaaggac ctgggcgtga ccaaggtggg ccacatgaag   3600

aggatcctgt gtggcatcaa ggagctgagc cgcagcgccc ccgccgtcga ggcctagcct   3660

ctgtcctctc agcctgtggc ctccacatcc ccgccgccga ggcctagcct ccgccctctc   3720

agcctgtggc ctctgcgcct cctgccactg aggccctggg cagatgctgc agcccgcccc   3780

cttctcatgg tgctacttcc tctgtcagct acagaaagcc tccgtgacac cgtccaccag   3840

agctctgggg tctcgaacat aacaacacag ctacctttga aacaacactt tctccagctc   3900

agagtcacct ggggcacatg tgtcacggcc actcagctct cgcccgcctg tgctgtgggc   3960

cagggaatcc agcggcgtct ggcctcctgg gcactgcttg cctggcctcg tgcttggatt   4020

gtcccggggg ctcctctccg tgtgtccttc tgtggccgca ccgtgtggct ccgcctcctg   4080

gcccccagcc agttctcaga aacgtggctg gggcccagca cagcagcctg caagggcccc   4140

tgtttgttga tgcagctttt gttgaacaaa aatcgtgctc tttcctggtt tgaaagtagc   4200

atggatgttt ccagtcttgt tgattgtaat ttgacgtgaa gagaaaaaaa aattcctcct   4260

gcgtgagcca aggcagcggg tgctgtttcc caggcgggga gcccctccct gggtgtcaca   4320

gggcctgtgc tcctccctcc tccatcctct ctcctcccgc tcctccctcc ccccactgtg   4380

ggctggggac gcctgccctt ctgtctccgg acgctctagg cgagttcagc ttggggtgtg   4440

agtgagacag cttgccagct gcatccctgc agacagagga tgtgtgtcca catgagtgtt   4500

tctgtgtggg aaatgcttcc tggctctggg aaactttttc tgcccattct gtggttccca   4560

gggagcgtgg ccctggtggg ccaggggtgg tttgacctct tcagcccgtc cggtggcctg   4620

gaggccggag gctctcctga gtgtctgccc ctgcagtggc ttcttgtcgc ctgctgctgg   4680

gcgtgatgtc gctggaggtg ctggcaggga ctctgatttg gtggtccgcg ctgcccctgc   4740

cctgcctctg tcctggctct gaactagtag atgatggtgc cagagggcag ggagctcgcc   4800

tggggagagg gctgtgcccc gtagggacag tgcccaggtg aaggatgccc ctggtcctcc   4860

agggcactga ctttgccctt ttttcccgtt gatagtcatg gctcagaggt gcttgtaaat   4920

gtcttgggaa gaggtttctg taacccctgc cctggtgtga ggaggaaatg gctctggcct   4980

ggctgcctgg ccgtggcttc tctttggctc ccaaagagaa ggacagtgtt gggagtatct   5040

gccgtggctt ctctttggct cccaaagaga aggacagtgt tgggagtatc tgccggcgct   5100

gtccaggtcc tttagtcagc gtcactccat ctgatgtgca gaagctgggc tgcacctgcg   5160

ggggtgggca tagaccgggc tgggtctgca gcagcccctg gtcctgagca ggcggcagtg   5220

aacagcactg gcccacctcc cactcacagc ccctctgtcc cctctgcagt gcacccaggt   5280

gggcccctct gcgtgccttt gggtgctccc ctctcgtggt cgttctggcc cgaggccctt   5340

agagtatgga ggctgagcca ggccttgggt ttccccagca cagcctcctg tcgctgcatg   5400

cgacgtgttg ggatttttgg atgaaagact ctcccacgct ctgttggtgg acttagctgc   5460

ctcactggaa gtgatgtggg tggaaggtgg ttgtatgtta ccttttccac ctctcattgt   5520

tttccccaga acattgtaga tgggggttgg cagagggaga aataagccag ccacggcagt   5580

cgcttggttt cccaggtgga atgggctaac acaggagatg atgggaacct gtcccgcagt   5640

ccctgcatga ccattggccc tgctggcctg gcgatgtggg catcctgggg ttcttagggt   5700

cccagaacaa gccccaggca agctggaact tgggtgggga ggggacatga ggaggataaa   5760

cagctgactg tggcttcaag gacatcaggg ccaccccaag tcctcagtgt cctactcctg   5820

gcaaggagtt gggtttggat caaaagtgtt taaaattaat atgttgtcag tgattagaac   5880

aacactgttt acataaaaac catttttcta attctaacaa gttagaatgt gaggaaggaa   5940

tgaacatgag tgtttaggaa cctgcccttt ggtgctgggc tggcgtcccg cactggggtg   6000

tcctcgctgt ctgggggctg ctctgctgcc ccggcccagg tccccttgtg gtgttgccag   6060

acgggcctca tggtctgctg tgcagagaga ggcaggaagg atccctgaag agtcttggag   6120

aaaaggttct gtgccctcag gtggggctta ccccctcgta tttataatct taatttatat   6180

agtgaccacc gtggaaacaa acgcctcttg tattgtcatg tacatagtcc atacctgagt   6240

gctgtacata agttgttctg tgtataaata aaacaagcct gtttttgatc ttccatc      6297


<210>  158
<211>  1214
<212>  PRT
<213>  Homosapiens

<400>  158

Met Ala Ala Ala Ala Gly Ala Pro Pro Pro Gly Pro Pro Gln Pro Pro 
1               5                   10                  15      


Pro Pro Pro Pro Pro Glu Glu Ser Ser Asp Ser Glu Pro Glu Ala Glu 
            20                  25                  30          


Pro Gly Ser Pro Gln Lys Leu Ile Arg Lys Val Ser Thr Ser Gly Gln 
        35                  40                  45              


Ile Arg Gln Lys Thr Ile Ile Lys Glu Gly Met Leu Thr Lys Gln Asn 
    50                  55                  60                  


Asn Ser Phe Gln Arg Ser Lys Arg Arg Tyr Phe Lys Leu Arg Gly Arg 
65                  70                  75                  80  


Thr Leu Tyr Tyr Ala Lys Thr Ala Lys Ser Ile Ile Phe Asp Glu Val 
                85                  90                  95      


Asp Leu Thr Asp Ala Ser Val Ala Glu Ser Ser Thr Lys Asn Val Asn 
            100                 105                 110         


Asn Ser Phe Thr Val Ile Thr Pro Cys Arg Lys Leu Ile Leu Cys Ala 
        115                 120                 125             


Asp Asn Arg Lys Glu Met Glu Asp Trp Ile Ala Ala Leu Lys Thr Val 
    130                 135                 140                 


Gln Asn Arg Glu His Phe Glu Pro Thr Gln Tyr Ser Met Asp His Phe 
145                 150                 155                 160 


Ser Gly Met His Asn Trp Tyr Ala Cys Ser His Ala Arg Pro Thr Tyr 
                165                 170                 175     


Cys Asn Val Cys Arg Glu Ala Leu Ser Gly Val Thr Ser His Gly Leu 
            180                 185                 190         


Ser Cys Glu Val Cys Lys Phe Lys Ala His Lys Arg Cys Ala Val Arg 
        195                 200                 205             


Ala Thr Asn Asn Cys Lys Trp Thr Thr Leu Ala Ser Ile Gly Lys Asp 
    210                 215                 220                 


Ile Ile Glu Asp Ala Asp Gly Ile Ala Met Pro His Gln Trp Leu Glu 
225                 230                 235                 240 


Gly Asn Leu Pro Val Ser Ala Lys Cys Thr Val Cys Asp Lys Thr Cys 
                245                 250                 255     


Gly Ser Val Leu Arg Leu Gln Asp Trp Arg Cys Leu Trp Cys Lys Ala 
            260                 265                 270         


Met Val His Thr Ser Cys Lys Glu Ser Leu Leu Thr Lys Cys Pro Leu 
        275                 280                 285             


Gly Leu Cys Lys Val Ser Val Ile Pro Pro Thr Ala Leu Asn Ser Ile 
    290                 295                 300                 


Asp Ser Asp Gly Phe Trp Lys Ala Ser Cys Pro Pro Ser Cys Thr Ser 
305                 310                 315                 320 


Pro Leu Leu Val Phe Val Asn Ser Lys Ser Gly Asp Asn Gln Gly Val 
                325                 330                 335     


Lys Phe Leu Arg Arg Phe Lys Gln Leu Leu Asn Pro Ala Gln Val Phe 
            340                 345                 350         


Asp Leu Met Asn Gly Gly Pro His Leu Gly Leu Arg Leu Phe Gln Lys 
        355                 360                 365             


Phe Asp Thr Phe Arg Ile Leu Val Cys Gly Gly Asp Gly Ser Val Gly 
    370                 375                 380                 


Trp Val Leu Ser Glu Ile Asp Ser Leu Asn Leu His Lys Gln Cys Gln 
385                 390                 395                 400 


Leu Gly Val Leu Pro Leu Gly Thr Gly Asn Asp Leu Ala Arg Val Leu 
                405                 410                 415     


Gly Trp Gly Ser Ala Cys Asp Asp Asp Thr Gln Leu Pro Gln Ile Leu 
            420                 425                 430         


Glu Lys Leu Glu Arg Ala Ser Thr Lys Met Leu Asp Arg Trp Ser Val 
        435                 440                 445             


Met Ala Tyr Glu Ala Lys Leu Pro Arg Gln Ala Ser Ser Ser Thr Val 
    450                 455                 460                 


Thr Glu Asp Phe Ser Glu Asp Ser Glu Val Gln Gln Ile Leu Phe Tyr 
465                 470                 475                 480 


Glu Asp Ser Val Ala Ala His Leu Ser Lys Ile Leu Thr Ser Asp Gln 
                485                 490                 495     


His Ser Val Val Ile Ser Ser Ala Lys Val Leu Cys Glu Thr Val Lys 
            500                 505                 510         


Asp Phe Val Ala Arg Val Gly Lys Ala Tyr Glu Lys Thr Thr Glu Ser 
        515                 520                 525             


Ser Glu Glu Ser Glu Val Met Ala Lys Lys Cys Ser Val Leu Lys Glu 
    530                 535                 540                 


Lys Leu Asp Ser Leu Leu Lys Thr Leu Asp Asp Glu Ser Gln Ala Ser 
545                 550                 555                 560 


Ser Ser Leu Pro Asn Pro Pro Pro Thr Ile Ala Glu Glu Ala Glu Asp 
                565                 570                 575     


Gly Asp Gly Ser Gly Ser Ile Cys Gly Ser Thr Gly Asp Arg Leu Val 
            580                 585                 590         


Ala Ser Ala Cys Pro Ala Arg Pro Gln Ile Phe Arg Pro Arg Glu Gln 
        595                 600                 605             


Leu Met Leu Arg Ala Asn Ser Leu Lys Lys Ala Ile Arg Gln Ile Ile 
    610                 615                 620                 


Glu His Thr Glu Lys Ala Val Asp Glu Gln Asn Ala Gln Thr Gln Glu 
625                 630                 635                 640 


Gln Glu Gly Phe Val Leu Gly Leu Ser Glu Ser Glu Glu Lys Met Asp 
                645                 650                 655     


His Arg Val Cys Pro Pro Leu Ser His Ser Glu Ser Phe Gly Val Pro 
            660                 665                 670         


Lys Gly Arg Ser Gln Arg Lys Val Ser Lys Ser Pro Cys Glu Lys Leu 
        675                 680                 685             


Ile Ser Lys Gly Ser Leu Ser Leu Gly Ser Ser Ala Ser Leu Pro Pro 
    690                 695                 700                 


Gln Pro Gly Ser Arg Asp Gly Leu Pro Ala Leu Asn Thr Lys Ile Leu 
705                 710                 715                 720 


Tyr Pro Asn Val Arg Ala Gly Met Ser Gly Ser Leu Pro Gly Gly Ser 
                725                 730                 735     


Val Ile Ser Arg Leu Leu Ile Asn Ala Asp Pro Phe Asn Ser Glu Pro 
            740                 745                 750         


Glu Thr Leu Glu Tyr Tyr Thr Glu Lys Cys Val Met Asn Asn Tyr Phe 
        755                 760                 765             


Gly Ile Gly Leu Asp Ala Lys Ile Ser Leu Asp Phe Asn Asn Lys Arg 
    770                 775                 780                 


Asp Glu His Pro Glu Lys Cys Arg Ser Arg Thr Lys Asn Met Met Trp 
785                 790                 795                 800 


Tyr Gly Val Leu Gly Thr Lys Glu Leu Leu His Arg Thr Tyr Lys Asn 
                805                 810                 815     


Leu Glu Gln Lys Val Leu Leu Glu Cys Asp Gly Arg Pro Ile Pro Leu 
            820                 825                 830         


Pro Ser Leu Gln Gly Ile Ala Val Leu Asn Ile Pro Ser Tyr Ala Gly 
        835                 840                 845             


Gly Thr Asn Phe Trp Gly Gly Thr Lys Glu Asp Asp Thr Phe Ala Ala 
    850                 855                 860                 


Pro Ser Phe Asp Asp Lys Ile Leu Glu Val Val Ala Val Phe Gly Ser 
865                 870                 875                 880 


Met Gln Met Ala Val Ser Arg Val Ile Arg Leu Gln His His Arg Ile 
                885                 890                 895     


Ala Gln Cys Arg Thr Val Lys Ile Ser Ile Leu Gly Asp Glu Gly Val 
            900                 905                 910         


Pro Val Gln Val Asp Gly Glu Ala Trp Val Gln Pro Pro Gly Tyr Ile 
        915                 920                 925             


Arg Ile Val His Lys Asn Arg Ala Gln Thr Leu Thr Arg Asp Arg Ala 
    930                 935                 940                 


Phe Glu Ser Thr Leu Lys Ser Trp Glu Asp Lys Gln Lys Cys Glu Leu 
945                 950                 955                 960 


Pro Arg Pro Pro Ser Cys Ser Leu His Pro Glu Met Leu Ser Glu Glu 
                965                 970                 975     


Glu Ala Thr Gln Met Asp Gln Phe Gly Gln Ala Ala Gly Val Leu Ile 
            980                 985                 990         


His Ser Ile Arg Glu Ile Ala Gln  Ser His Arg Asp Met  Glu Gln Glu 
        995                 1000                 1005             


Leu Ala  His Ala Val Asn Ala  Ser Ser Lys Ser Met  Asp Arg Val 
    1010                 1015                 1020             


Tyr Gly  Lys Pro Arg Thr Thr  Glu Gly Leu Asn Cys  Ser Phe Val 
    1025                 1030                 1035             


Leu Glu  Met Val Asn Asn Phe  Arg Ala Leu Arg Ser  Glu Thr Glu 
    1040                 1045                 1050             


Leu Leu  Leu Ser Gly Lys Met  Ala Leu Gln Leu Asp  Pro Pro Gln 
    1055                 1060                 1065             


Lys Glu  Gln Leu Gly Ser Ala  Leu Ala Glu Met Asp  Arg Gln Leu 
    1070                 1075                 1080             


Arg Arg  Leu Ala Asp Thr Pro  Trp Leu Cys Gln Ser  Ala Glu Pro 
    1085                 1090                 1095             


Gly Asp  Glu Glu Ser Val Met  Leu Asp Leu Ala Lys  Arg Ser Arg 
    1100                 1105                 1110             


Ser Gly  Lys Phe Arg Leu Val  Thr Lys Phe Lys Lys  Glu Lys Asn 
    1115                 1120                 1125             


Asn Lys  Asn Lys Glu Ala His  Ser Ser Leu Gly Ala  Pro Val His 
    1130                 1135                 1140             


Leu Trp  Gly Thr Glu Glu Val  Ala Ala Trp Leu Glu  His Leu Ser 
    1145                 1150                 1155             


Leu Cys  Glu Tyr Lys Asp Ile  Phe Thr Arg His Asp  Ile Arg Gly 
    1160                 1165                 1170             


Ser Glu  Leu Leu His Leu Glu  Arg Arg Asp Leu Lys  Asp Leu Gly 
    1175                 1180                 1185             


Val Thr  Lys Val Gly His Met  Lys Arg Ile Leu Cys  Gly Ile Lys 
    1190                 1195                 1200             


Glu Leu  Ser Arg Ser Ala Pro  Ala Val Glu Ala 
    1205                 1210                 


<210>  159
<211>  621
<212>  DNA
<213>  Homosapiens

<400>  159
cgccgcccga ggagtcgtcc gacagcgagc ccgaggcgga gcccggctcc ccacagaagc     60

tcatccgcaa ggtgtccacg tcgggtcaga tccgacagaa gaccatcatc aaagagggga    120

tgctgaccaa acagaacaat tcattccagc gatcaaaaag gagatacttt aagcttcgag    180

ggcgaacgct ttactatgcc aaaacggcaa agtcaatcat atttgatgag gtggatctga    240

cagatgccag cgtagctgaa tccagtacca aaaacgtcaa caacagtttt acggctgaag    300

tgcggtggtg tgatctcggc tcactgcaac ctccgtctcc caggttcaag ggatcctcat    360

gcctcagcct ccctagtagc tgggattata gtcgtgcacc gttatgccca gataatcttc    420

gtaattttag tagagatggg gtttcaccat attggccagg ctggtctcaa actcctggcc    480

tggagtgatc tacccgcctg aaccttccaa agtactggga ttacaggcat gagccactgt    540

gcctggccct gggcattaat ttagatgttc attttggttt cagttatttg catatttcct    600

aataaaaaaa ttattcttgg t                                              621


<210>  160
<211>  122
<212>  PRT
<213>  Homosapiens

<400>  160

Met Leu Thr Lys Gln Asn Asn Ser Phe Gln Arg Ser Lys Arg Arg Tyr 
1               5                   10                  15      


Phe Lys Leu Arg Gly Arg Thr Leu Tyr Tyr Ala Lys Thr Ala Lys Ser 
            20                  25                  30          


Ile Ile Phe Asp Glu Val Asp Leu Thr Asp Ala Ser Val Ala Glu Ser 
        35                  40                  45              


Ser Thr Lys Asn Val Asn Asn Ser Phe Thr Ala Glu Val Arg Trp Cys 
    50                  55                  60                  


Asp Leu Gly Ser Leu Gln Pro Pro Ser Pro Arg Phe Lys Gly Ser Ser 
65                  70                  75                  80  


Cys Leu Ser Leu Pro Ser Ser Trp Asp Tyr Ser Arg Ala Pro Leu Cys 
                85                  90                  95      


Pro Asp Asn Leu Arg Asn Phe Ser Arg Asp Gly Val Ser Pro Tyr Trp 
            100                 105                 110         


Pro Gly Trp Ser Gln Thr Pro Gly Leu Glu 
        115                 120         


<210>  161
<211>  6232
<212>  DNA
<213>  Homosapiens

<400>  161
agagacacga atatgtttca gccgcaacag gctgcgtttc agccggaaga gtgaaagggc     60

accttgaaaa cgcaagttta tgaatatgtt tctgtacttt cagaccatca tcaaagaggg    120

gatgctgacc aaacagaaca attcattcca gcgatcaaaa aggagatact ttaagcttcg    180

agggcgaacg ctttactatg ccaaaacggc aaagtcaatc atatttgatg aggtggatct    240

gacagatgcc agcgtagctg aatccagtac caaaaacgtc aacaacagtt ttacggtcat    300

aactccatgc aggaagctca tcttgtgtgc tgataacaga aaagaaatgg aagattggat    360

tgcagcatta aagactgtgc agaacaggga gcactttgag cccacccagt acagcatgga    420

ccacttctca gggatgcaca attggtacgc ctgttcccac gcgaggccga cctactgcaa    480

tgtgtgccgt gaggctctgt ctggggtcac gtcgcacggg ctgtcctgcg aggtgtgcaa    540

atttaaggcc cacaagcgct gtgctgtgcg tgcaaccaat aactgcaagt ggaccacact    600

ggcctcgatc gggaaggaca tcattgaaga tgcagatggg attgcaatgc cccaccagtg    660

gttggaagga aacctacctg tgagcgccaa gtgcactgtg tgcgacaaga cctgtggcag    720

tgtgctgcgc ctgcaggact ggcgctgcct ctggtgcaag gccatggttc acacatcgtg    780

taaagaatcc ttgctgacca agtgcccact tggcctgtgc aaagtgtcag tcatcccacc    840

cacggctctc aacagcatcg actccgatgg gttctggaag gccagctgtc ctccttcttg    900

cacaagccca ctgttggtct tcgtcaattc aaaaagtggg gacaaccagg gtgtgaagtt    960

cctcagaaga ttcaaacagc tactaaaccc cgcccaggtc ttcgacctca tgaacggagg   1020

cccacacctc ggcttacggt tattccagaa gtttgacaca ttccggattc tggtttgtgg   1080

cggggatgga agtgttggct gggtcctctc cgaaatcgac agcctcaacc ttcataaaca   1140

gtgtcagctg ggagtgctgc cgctcggcac agggaacgac ttggcccgag tactgggctg   1200

gggctcagcc tgcgatgacg acacccagct cccccagatc ttggagaagt tggagagagc   1260

cagcaccaag atgctggaca ggtggagcgt catggcatac gaggccaagc tcccccggca   1320

ggcctcctcc tctaccgtca ccgaagactt cagcgaggat tccgaggtac agcagattct   1380

cttctatgaa gactcggttg cagcccacct ttctaaaatc ctcacctcgg accagcactc   1440

ggtggtcatc tcctcggcca aagtgctctg tgagacggtg aaggacttcg tggcacgggt   1500

ggggaaggcc tatgagaaga cgaccgagag ctcggaggag tcagaggtca tggccaagaa   1560

gtgctctgtc ctgaaagaga agctggattc ccttctcaag accttggacg atgagtccca   1620

ggcctcgtcc tctctgccca acccgccccc caccattgcc gaggaggctg aagatggaga   1680

tgggtcgggc agcatctgcg gttccaccgg agaccgcttg gtggcatcag cttgcccggc   1740

ccggccgcag atattccggc ctcgagaaca gctcatgctg agagccaaca gcctgaagaa   1800

agcaattcgt cagatcatag aacacacaga aaaagctgtc gatgagcaga atgcccagac   1860

ccaggagcag gagggcttcg tcctgggcct ctctgagtca gaggagaaga tggaccacag   1920

agtgtgccca ccactgtccc acagcgagag cttcggggtc cccaagggga ggagccagcg   1980

caaagtgtcg aaatctccgt gtgaaaagct gatcagcaaa gggagtctgt ccctaggcag   2040

ttctgcttcc cttccgcccc agccgggaag ccgggacggc ctgcctgcgc tcaacaccaa   2100

gatcctgtac ccaaatgtcc gggctggaat gtctggttcc ttacccggtg gctcagtcat   2160

cagtcgcctg ttaattaatg ctgatccctt caactctgaa ccagaaaccc tagagtatta   2220

cacggagaaa tgtgtcatga acaactattt tggcattggc ctggatgcga agatatccct   2280

ggactttaac aacaagcgcg atgagcaccc agagaagtgc aggagccgaa ccaagaacat   2340

gatgtggtat ggagttcttg gaaccaaaga gttgctgcac agaacctaca agaacctgga   2400

gcaaaaggtc ttgctggagt gtgacgggcg acccatccca ctccccagtc ttcagggaat   2460

tgctgtcctt aacattccca gctatgccgg aggaaccaac ttctgggggg gtaccaagga   2520

agatgatact ttcgcagctc catcattcga tgacaagatt ctggaggtgg tcgccgtgtt   2580

cggcagcatg cagatggccg tctctcgagt catcaggcta cagcatcatc ggatcgccca   2640

gtgtcgcacg gtgaagatct ccatccttgg ggatgagggc gtgcctgtgc aggtggacgg   2700

agaggcctgg gtccagccgc cagggtacat tcggattgtc cacaagaacc gggcacagac   2760

actgaccaga gacagggcat ttgagagcac cctgaagtcc tgggaagaca agcagaagtg   2820

cgagctgccc cgccctccat cctgttccct gcacccggag atgctgtccg aggaggaggc   2880

cacccagatg gaccagtttg ggcaggcagc aggggtcctc attcacagta tccgagaaat   2940

agctcagtct caccgggaca tggagcagga actggcccac gccgtcaatg ccagctccaa   3000

gtccatggac cgtgtgtatg gcaagcccag aaccacagag gggctcaact gcagcttcgt   3060

cctggaaatg gtgaataact tcagagctct gcgcagtgag acggagctgc tgctgtctgg   3120

gaagatggcc ctgcagctgg atccgcctca gaaggagcag ctggggagtg ctcttgccga   3180

gatggaccga cagctcagga ggctggcaga caccccgtgg ctctgccagt ccgcagagcc   3240

cggcgacgaa gagagtgtga tgctggatct tgccaagcgc agtcgcagtg gtaaattccg   3300

cctcgtgacc aagtttaaaa aggagaaaaa caacaagaac aaagaagctc acagtagcct   3360

gggagccccg gttcacctct gggggacaga ggaggttgct gcctggctgg agcacctcag   3420

tctctgtgag tataaggaca tcttcacacg gcacgacatc cggggctctg agctcctgca   3480

cctggagcgg agggacctca aggacctggg cgtgaccaag gtgggccaca tgaagaggat   3540

cctgtgtggc atcaaggagc tgagccgcag cgcccccgcc gtcgaggcct agcctctgtc   3600

ctctcagcct gtggcctcca catccccgcc gccgaggcct agcctccgcc ctctcagcct   3660

gtggcctctg cgcctcctgc cactgaggcc ctgggcagat gctgcagccc gcccccttct   3720

catggtgcta cttcctctgt cagctacaga aagcctccgt gacaccgtcc accagagctc   3780

tggggtctcg aacataacaa cacagctacc tttgaaacaa cactttctcc agctcagagt   3840

cacctggggc acatgtgtca cggccactca gctctcgccc gcctgtgctg tgggccaggg   3900

aatccagcgg cgtctggcct cctgggcact gcttgcctgg cctcgtgctt ggattgtccc   3960

gggggctcct ctccgtgtgt ccttctgtgg ccgcaccgtg tggctccgcc tcctggcccc   4020

cagccagttc tcagaaacgt ggctggggcc cagcacagca gcctgcaagg gcccctgttt   4080

gttgatgcag cttttgttga acaaaaatcg tgctctttcc tggtttgaaa gtagcatgga   4140

tgtttccagt cttgttgatt gtaatttgac gtgaagagaa aaaaaaattc ctcctgcgtg   4200

agccaaggca gcgggtgctg tttcccaggc ggggagcccc tccctgggtg tcacagggcc   4260

tgtgctcctc cctcctccat cctctctcct cccgctcctc cctcccccca ctgtgggctg   4320

gggacgcctg cccttctgtc tccggacgct ctaggcgagt tcagcttggg gtgtgagtga   4380

gacagcttgc cagctgcatc cctgcagaca gaggatgtgt gtccacatga gtgtttctgt   4440

gtgggaaatg cttcctggct ctgggaaact ttttctgccc attctgtggt tcccagggag   4500

cgtggccctg gtgggccagg ggtggtttga cctcttcagc ccgtccggtg gcctggaggc   4560

cggaggctct cctgagtgtc tgcccctgca gtggcttctt gtcgcctgct gctgggcgtg   4620

atgtcgctgg aggtgctggc agggactctg atttggtggt ccgcgctgcc cctgccctgc   4680

ctctgtcctg gctctgaact agtagatgat ggtgccagag ggcagggagc tcgcctgggg   4740

agagggctgt gccccgtagg gacagtgccc aggtgaagga tgcccctggt cctccagggc   4800

actgactttg cccttttttc ccgttgatag tcatggctca gaggtgcttg taaatgtctt   4860

gggaagaggt ttctgtaacc cctgccctgg tgtgaggagg aaatggctct ggcctggctg   4920

cctggccgtg gcttctcttt ggctcccaaa gagaaggaca gtgttgggag tatctgccgt   4980

ggcttctctt tggctcccaa agagaaggac agtgttggga gtatctgccg gcgctgtcca   5040

ggtcctttag tcagcgtcac tccatctgat gtgcagaagc tgggctgcac ctgcgggggt   5100

gggcatagac cgggctgggt ctgcagcagc ccctggtcct gagcaggcgg cagtgaacag   5160

cactggccca cctcccactc acagcccctc tgtcccctct gcagtgcacc caggtgggcc   5220

cctctgcgtg cctttgggtg ctcccctctc gtggtcgttc tggcccgagg cccttagagt   5280

atggaggctg agccaggcct tgggtttccc cagcacagcc tcctgtcgct gcatgcgacg   5340

tgttgggatt tttggatgaa agactctccc acgctctgtt ggtggactta gctgcctcac   5400

tggaagtgat gtgggtggaa ggtggttgta tgttaccttt tccacctctc attgttttcc   5460

ccagaacatt gtagatgggg gttggcagag ggagaaataa gccagccacg gcagtcgctt   5520

ggtttcccag gtggaatggg ctaacacagg agatgatggg aacctgtccc gcagtccctg   5580

catgaccatt ggccctgctg gcctggcgat gtgggcatcc tggggttctt agggtcccag   5640

aacaagcccc aggcaagctg gaacttgggt ggggagggga catgaggagg ataaacagct   5700

gactgtggct tcaaggacat cagggccacc ccaagtcctc agtgtcctac tcctggcaag   5760

gagttgggtt tggatcaaaa gtgtttaaaa ttaatatgtt gtcagtgatt agaacaacac   5820

tgtttacata aaaaccattt ttctaattct aacaagttag aatgtgagga aggaatgaac   5880

atgagtgttt aggaacctgc cctttggtgc tgggctggcg tcccgcactg gggtgtcctc   5940

gctgtctggg ggctgctctg ctgccccggc ccaggtcccc ttgtggtgtt gccagacggg   6000

cctcatggtc tgctgtgcag agagaggcag gaaggatccc tgaagagtct tggagaaaag   6060

gttctgtgcc ctcaggtggg gcttaccccc tcgtatttat aatcttaatt tatatagtga   6120

ccaccgtgga aacaaacgcc tcttgtattg tcatgtacat agtccatacc tgagtgctgt   6180

acataagttg ttctgtgtat aaataaaaca agcctgtttt tgatcttcca tc           6232


<210>  162
<211>  1170
<212>  PRT
<213>  Homosapiens

<400>  162

Met Asn Met Phe Leu Tyr Phe Gln Thr Ile Ile Lys Glu Gly Met Leu 
1               5                   10                  15      


Thr Lys Gln Asn Asn Ser Phe Gln Arg Ser Lys Arg Arg Tyr Phe Lys 
            20                  25                  30          


Leu Arg Gly Arg Thr Leu Tyr Tyr Ala Lys Thr Ala Lys Ser Ile Ile 
        35                  40                  45              


Phe Asp Glu Val Asp Leu Thr Asp Ala Ser Val Ala Glu Ser Ser Thr 
    50                  55                  60                  


Lys Asn Val Asn Asn Ser Phe Thr Val Ile Thr Pro Cys Arg Lys Leu 
65                  70                  75                  80  


Ile Leu Cys Ala Asp Asn Arg Lys Glu Met Glu Asp Trp Ile Ala Ala 
                85                  90                  95      


Leu Lys Thr Val Gln Asn Arg Glu His Phe Glu Pro Thr Gln Tyr Ser 
            100                 105                 110         


Met Asp His Phe Ser Gly Met His Asn Trp Tyr Ala Cys Ser His Ala 
        115                 120                 125             


Arg Pro Thr Tyr Cys Asn Val Cys Arg Glu Ala Leu Ser Gly Val Thr 
    130                 135                 140                 


Ser His Gly Leu Ser Cys Glu Val Cys Lys Phe Lys Ala His Lys Arg 
145                 150                 155                 160 


Cys Ala Val Arg Ala Thr Asn Asn Cys Lys Trp Thr Thr Leu Ala Ser 
                165                 170                 175     


Ile Gly Lys Asp Ile Ile Glu Asp Ala Asp Gly Ile Ala Met Pro His 
            180                 185                 190         


Gln Trp Leu Glu Gly Asn Leu Pro Val Ser Ala Lys Cys Thr Val Cys 
        195                 200                 205             


Asp Lys Thr Cys Gly Ser Val Leu Arg Leu Gln Asp Trp Arg Cys Leu 
    210                 215                 220                 


Trp Cys Lys Ala Met Val His Thr Ser Cys Lys Glu Ser Leu Leu Thr 
225                 230                 235                 240 


Lys Cys Pro Leu Gly Leu Cys Lys Val Ser Val Ile Pro Pro Thr Ala 
                245                 250                 255     


Leu Asn Ser Ile Asp Ser Asp Gly Phe Trp Lys Ala Ser Cys Pro Pro 
            260                 265                 270         


Ser Cys Thr Ser Pro Leu Leu Val Phe Val Asn Ser Lys Ser Gly Asp 
        275                 280                 285             


Asn Gln Gly Val Lys Phe Leu Arg Arg Phe Lys Gln Leu Leu Asn Pro 
    290                 295                 300                 


Ala Gln Val Phe Asp Leu Met Asn Gly Gly Pro His Leu Gly Leu Arg 
305                 310                 315                 320 


Leu Phe Gln Lys Phe Asp Thr Phe Arg Ile Leu Val Cys Gly Gly Asp 
                325                 330                 335     


Gly Ser Val Gly Trp Val Leu Ser Glu Ile Asp Ser Leu Asn Leu His 
            340                 345                 350         


Lys Gln Cys Gln Leu Gly Val Leu Pro Leu Gly Thr Gly Asn Asp Leu 
        355                 360                 365             


Ala Arg Val Leu Gly Trp Gly Ser Ala Cys Asp Asp Asp Thr Gln Leu 
    370                 375                 380                 


Pro Gln Ile Leu Glu Lys Leu Glu Arg Ala Ser Thr Lys Met Leu Asp 
385                 390                 395                 400 


Arg Trp Ser Val Met Ala Tyr Glu Ala Lys Leu Pro Arg Gln Ala Ser 
                405                 410                 415     


Ser Ser Thr Val Thr Glu Asp Phe Ser Glu Asp Ser Glu Val Gln Gln 
            420                 425                 430         


Ile Leu Phe Tyr Glu Asp Ser Val Ala Ala His Leu Ser Lys Ile Leu 
        435                 440                 445             


Thr Ser Asp Gln His Ser Val Val Ile Ser Ser Ala Lys Val Leu Cys 
    450                 455                 460                 


Glu Thr Val Lys Asp Phe Val Ala Arg Val Gly Lys Ala Tyr Glu Lys 
465                 470                 475                 480 


Thr Thr Glu Ser Ser Glu Glu Ser Glu Val Met Ala Lys Lys Cys Ser 
                485                 490                 495     


Val Leu Lys Glu Lys Leu Asp Ser Leu Leu Lys Thr Leu Asp Asp Glu 
            500                 505                 510         


Ser Gln Ala Ser Ser Ser Leu Pro Asn Pro Pro Pro Thr Ile Ala Glu 
        515                 520                 525             


Glu Ala Glu Asp Gly Asp Gly Ser Gly Ser Ile Cys Gly Ser Thr Gly 
    530                 535                 540                 


Asp Arg Leu Val Ala Ser Ala Cys Pro Ala Arg Pro Gln Ile Phe Arg 
545                 550                 555                 560 


Pro Arg Glu Gln Leu Met Leu Arg Ala Asn Ser Leu Lys Lys Ala Ile 
                565                 570                 575     


Arg Gln Ile Ile Glu His Thr Glu Lys Ala Val Asp Glu Gln Asn Ala 
            580                 585                 590         


Gln Thr Gln Glu Gln Glu Gly Phe Val Leu Gly Leu Ser Glu Ser Glu 
        595                 600                 605             


Glu Lys Met Asp His Arg Val Cys Pro Pro Leu Ser His Ser Glu Ser 
    610                 615                 620                 


Phe Gly Val Pro Lys Gly Arg Ser Gln Arg Lys Val Ser Lys Ser Pro 
625                 630                 635                 640 


Cys Glu Lys Leu Ile Ser Lys Gly Ser Leu Ser Leu Gly Ser Ser Ala 
                645                 650                 655     


Ser Leu Pro Pro Gln Pro Gly Ser Arg Asp Gly Leu Pro Ala Leu Asn 
            660                 665                 670         


Thr Lys Ile Leu Tyr Pro Asn Val Arg Ala Gly Met Ser Gly Ser Leu 
        675                 680                 685             


Pro Gly Gly Ser Val Ile Ser Arg Leu Leu Ile Asn Ala Asp Pro Phe 
    690                 695                 700                 


Asn Ser Glu Pro Glu Thr Leu Glu Tyr Tyr Thr Glu Lys Cys Val Met 
705                 710                 715                 720 


Asn Asn Tyr Phe Gly Ile Gly Leu Asp Ala Lys Ile Ser Leu Asp Phe 
                725                 730                 735     


Asn Asn Lys Arg Asp Glu His Pro Glu Lys Cys Arg Ser Arg Thr Lys 
            740                 745                 750         


Asn Met Met Trp Tyr Gly Val Leu Gly Thr Lys Glu Leu Leu His Arg 
        755                 760                 765             


Thr Tyr Lys Asn Leu Glu Gln Lys Val Leu Leu Glu Cys Asp Gly Arg 
    770                 775                 780                 


Pro Ile Pro Leu Pro Ser Leu Gln Gly Ile Ala Val Leu Asn Ile Pro 
785                 790                 795                 800 


Ser Tyr Ala Gly Gly Thr Asn Phe Trp Gly Gly Thr Lys Glu Asp Asp 
                805                 810                 815     


Thr Phe Ala Ala Pro Ser Phe Asp Asp Lys Ile Leu Glu Val Val Ala 
            820                 825                 830         


Val Phe Gly Ser Met Gln Met Ala Val Ser Arg Val Ile Arg Leu Gln 
        835                 840                 845             


His His Arg Ile Ala Gln Cys Arg Thr Val Lys Ile Ser Ile Leu Gly 
    850                 855                 860                 


Asp Glu Gly Val Pro Val Gln Val Asp Gly Glu Ala Trp Val Gln Pro 
865                 870                 875                 880 


Pro Gly Tyr Ile Arg Ile Val His Lys Asn Arg Ala Gln Thr Leu Thr 
                885                 890                 895     


Arg Asp Arg Ala Phe Glu Ser Thr Leu Lys Ser Trp Glu Asp Lys Gln 
            900                 905                 910         


Lys Cys Glu Leu Pro Arg Pro Pro Ser Cys Ser Leu His Pro Glu Met 
        915                 920                 925             


Leu Ser Glu Glu Glu Ala Thr Gln Met Asp Gln Phe Gly Gln Ala Ala 
    930                 935                 940                 


Gly Val Leu Ile His Ser Ile Arg Glu Ile Ala Gln Ser His Arg Asp 
945                 950                 955                 960 


Met Glu Gln Glu Leu Ala His Ala Val Asn Ala Ser Ser Lys Ser Met 
                965                 970                 975     


Asp Arg Val Tyr Gly Lys Pro Arg Thr Thr Glu Gly Leu Asn Cys Ser 
            980                 985                 990         


Phe Val Leu Glu Met Val Asn Asn  Phe Arg Ala Leu Arg  Ser Glu Thr 
        995                 1000                 1005             


Glu Leu  Leu Leu Ser Gly Lys  Met Ala Leu Gln Leu  Asp Pro Pro 
    1010                 1015                 1020             


Gln Lys  Glu Gln Leu Gly Ser  Ala Leu Ala Glu Met  Asp Arg Gln 
    1025                 1030                 1035             


Leu Arg  Arg Leu Ala Asp Thr  Pro Trp Leu Cys Gln  Ser Ala Glu 
    1040                 1045                 1050             


Pro Gly  Asp Glu Glu Ser Val  Met Leu Asp Leu Ala  Lys Arg Ser 
    1055                 1060                 1065             


Arg Ser  Gly Lys Phe Arg Leu  Val Thr Lys Phe Lys  Lys Glu Lys 
    1070                 1075                 1080             


Asn Asn  Lys Asn Lys Glu Ala  His Ser Ser Leu Gly  Ala Pro Val 
    1085                 1090                 1095             


His Leu  Trp Gly Thr Glu Glu  Val Ala Ala Trp Leu  Glu His Leu 
    1100                 1105                 1110             


Ser Leu  Cys Glu Tyr Lys Asp  Ile Phe Thr Arg His  Asp Ile Arg 
    1115                 1120                 1125             


Gly Ser  Glu Leu Leu His Leu  Glu Arg Arg Asp Leu  Lys Asp Leu 
    1130                 1135                 1140             


Gly Val  Thr Lys Val Gly His  Met Lys Arg Ile Leu  Cys Gly Ile 
    1145                 1150                 1155             


Lys Glu  Leu Ser Arg Ser Ala  Pro Ala Val Glu Ala  
    1160                 1165                 1170 


<210>  163
<211>  424
<212>  DNA
<213>  Homosapiens

<400>  163
tcattccctc cagggaaaga ttttcctttg atcttctcca ttttctcttg ggttttcaca     60

tgttttcatt gacttaggat ttctcccctg atttattaaa ctttgtgtta tagtaatttt    120

agttgttgtc ttcaagtcct acgcttgttt gctttttttg agacacctgg gcaacaagag    180

tgaaactctg tctaaaaaaa aaaaaaagaa agaaaaaaaa agaggtgatc aggccaggag    240

ggctctgctc tggggatgga ttaatgctgt tattgtaggg gtcagttcct aataaaggga    300

tgagttcatc tcctccccct tgttctcact gtcacctttg acgcagcatg aagcccctca    360

ccagatgccg caccatgctc ttagactttc gaactatgag gcaaataaac ttctgttcat    420

ttaa                                                                 424


<210>  164
<211>  66
<212>  PRT
<213>  Homosapiens

<400>  164

Phe Ile Lys Leu Cys Val Ile Val Ile Leu Val Val Val Phe Lys Ser 
1               5                   10                  15      


Tyr Ala Cys Leu Leu Phe Leu Arg His Leu Gly Asn Lys Ser Glu Thr 
            20                  25                  30          


Leu Ser Lys Lys Lys Lys Lys Lys Glu Lys Lys Arg Gly Asp Gln Ala 
        35                  40                  45              


Arg Arg Ala Leu Leu Trp Gly Trp Ile Asn Ala Val Ile Val Gly Val 
    50                  55                  60                  


Ser Ser 
65      


<210>  165
<211>  270
<212>  DNA
<213>  Homosapiens

<400>  165
cggggatgtg tggagtggtg gtcagctcta acgtgtccct tgcagacttt cgcagctcca     60

tcattcgatg acaagattct ggaggtggtc gccgtgttcg gcagcatgca gatggccgtc    120

tctcgagtca tcaggctaca gcatcatcgg atcgcccagt gtcgcacggt gaagatctcc    180

atccttgggg atgagggcgt gcctgtgcag gtggacggag aggcctgggt ccagccgcca    240

gggtacattc ggattgtcca caagaaccgg                                     270


<210>  166
<211>  54
<212>  PRT
<213>  Homosapiens

<400>  166

Met Gln Met Ala Val Ser Arg Val Ile Arg Leu Gln His His Arg Ile 
1               5                   10                  15      


Ala Gln Cys Arg Thr Val Lys Ile Ser Ile Leu Gly Asp Glu Gly Val 
            20                  25                  30          


Pro Val Gln Val Asp Gly Glu Ala Trp Val Gln Pro Pro Gly Tyr Ile 
        35                  40                  45              


Arg Ile Val His Lys Asn 
    50                  


<210>  167
<211>  535
<212>  DNA
<213>  Homosapiens

<400>  167
tgcaaggttc gactgctgac tttgcttccc acagcatttc cactgcttga cacaggtgaa     60

tggctccgac cccatttctg acagagggac acaagcaggt cagttgtcag ccttgctcta    120

tgtgaattca tcgttgactg atggacagtt ttattctctc accagcacta cttagaaagt    180

gaggttctgg gtttggttcc ttttctggtg ctctgggact tcgtttctgg aaagtgagct    240

ccctgatcag agcagagcag agccctggag cggacctcac ccccctgggc ctcgcgctga    300

tcagcagtgc acactctcca tttctctctc cctccctccg cctggagcag cagctggatc    360

cgcctcagaa ggagcagctg gggagtgctc ttgccgagat ggaccgacag ctcaggaggc    420

tggcagacac cccgtggctc tgccagtccg cagagcccgg cgacgaagag agtgtgatgc    480

tggatcttgc caagcgcagt cgcagtggta aattccgcct cgtgaccaag tttaa         535


<210>  168
<211>  44
<212>  PRT
<213>  Homosapiens

<400>  168

Met Asp Arg Gln Leu Arg Arg Leu Ala Asp Thr Pro Trp Leu Cys Gln 
1               5                   10                  15      


Ser Ala Glu Pro Gly Asp Glu Glu Ser Val Met Leu Asp Leu Ala Lys 
            20                  25                  30          


Arg Ser Arg Ser Gly Lys Phe Arg Leu Val Thr Lys 
        35                  40                  


<210>  169
<211>  2729
<212>  DNA
<213>  Homosapiens

<400>  169
gagagattcc tgtgactttt aaaatgatgt tatcattact tgagatactc tttccttgag     60

atgccactgt gtagtgcttc attttttttt tctaaaacag tatgttttga agagtgcttt    120

ttaaaaccgt tggagaaatg tctgtttctt tttctaggcc atgaccttgc ctcctttcct    180

ggagttcggt gtcccgtccc cagcccacct cagagcctgg acggtggaga ggaagcgccc    240

aggcaggctt ttacgaactg accggcagcc actcagggaa tataaactag gacggagaat    300

tgagatctgc ttagagcccc ttcagaaagg cgaaaacttg ggcccccagg acgtgctgct    360

gaggacacag gtgcgcatcc ctggtgagag gacctatgcc cctgccctgg acctggtgtg    420

gaacgcggcc cagggtggga ctgccggctc cctgaggcag agagttgccg atttctatcg    480

tcttcccgtg gagaagattg aaattgccaa atactttccc gaaaagttcg agtggcttcc    540

gatatctagc tggaaccaac aaataaccaa gaggaaaaag aaaaaaaaac aagattattt    600

gcaaggggca ccgtattact tgaaagacgg agatactatt ggtgttaaga atctcctgat    660

tgacgacgat gatgatttca gtacaatcag agatgacact ggaaaagaaa agcagaaaca    720

acgggccctg gggagaagga aaagccaaga agccctccat gagcagagca gctacatcct    780

ctccagtgca gagacgcctg cccggccccg agccccggaa acttctctct ccatccacgt    840

ggggagcttc agataaccgc gccgctgcac ggctctactc ccgatgaact ctccggctga    900

tgccacaaac gtgggtttcc tgggcatggg gactggctgc ctggcgcctc caatcccaaa    960

tcctctgctt cctttgagca cagggacggc tcctctgagg cctggccagt gcatgtagtc   1020

acttagctct gcaacacgtg gcagccacgg gggctggtgc agctctggat gtcgcccacc   1080

cagctgccag taggtgctgg gctctctcac acagcacccg gccccagctg cctttttttt   1140

tcttttaacc agaaaatgca caacgtgtgc gtgaaccgca ggtatggagg cagcggcatg   1200

ccgttgctcc gctgtgggag gtgtgtgggg tcaggccagc cactttcctc cgtgttcaga   1260

tgactctcgt tcgccctgac cggcttctca cagtgtctca ggccactgcg ccaccgcgct   1320

ggtgctgagc agaagcgggc agaagtgggg tctgctttca ggacttcatt tcccccactc   1380

gttccggccc cgcatgctcc acgtctgccc tttggtctga gttaaaactg cgatgctgaa   1440

aagtgcgagc tctttccacg aggaggagcc acacagggtg gcctccgagg gtgagtcgct   1500

ctgctaagca agggcagccg ctgcacgtca gcccgcaggc caagggtcca gcttatcctg   1560

ggtgctctgt gatcagaagg tccttggatc ccgaggactg cagctgctgc cgtccacagc   1620

gcctcagcct ctcttcctgt gtggaagcgg ggcaggcagg gctgtggcag acaggcctgg   1680

catagcccag gttccaggtg tcctgggcag cctgaccggt ttcctgagta gcctcaatga   1740

aaacacctga gaaaaagaaa atgtaaacta aggaagggtt ttcccactta atccaaccca   1800

gatttctatt caacttaaag gatttaattg gcatttgtga gaaataatag tacctgtgtc   1860

actgagttga ttgatttggg acatagacgg ttgactttcc cagacagcag cttagcggaa   1920

agcagcatcc cgaagacggt gtcgcatgtc ctgagcctgc ttgtcacctg ggcctcacgg   1980

tttctcgtca gccccgtcac tgatgggaag cagcactgaa gtgtgagggc agaaaggaca   2040

ccgctggagt caggcgctcc cctgcctgtg acccttttcc aacaagctga tgctgagcca   2100

gcggcctgct ttgtccctca tactcctccc aacagtccaa acccctacca gacagaagcc   2160

acgtcgcttc tgcacacgtg tctgagagcg tctgccatag acgtctgtgc gtttccgtga   2220

agcactgcgc cctaaggacc caactctgac tagcagctgc ctcccactcc caaacactaa   2280

ccccgctcag gagactcgca ctgggtgtag actgcgtctt tgcagaggga gatgatagag   2340

gcttctgatg acgccagagc tgtaagtgtc gtgacgagct gggcgcccag cccttcttaa   2400

gctgttctgt ttctgtggct ttaactgaca tatttctgta gcatctgcct tcatctcatc   2460

tcagcgtaat gaaatattaa tgaaatcgct gaaaagcttt gccttcgaga ggccagaagc   2520

ctcgcggaat gtctgcaagt ccaaagacgc gtgtgggttg tgccctgaag tgccgtccag   2580

caggcgcgtg cggccgggcc ggcctgtgcg tgtggccttt gccttcttcc ctttcttcct   2640

gttttctgtt tttttaattt ggggattgag aaagctgtac gattttgtta aagaaaaaaa   2700

taaaccattt tttaaagttg tagccctta                                     2729


<210>  170
<211>  231
<212>  PRT
<213>  Homosapiens

<400>  170

Met Thr Leu Pro Pro Phe Leu Glu Phe Gly Val Pro Ser Pro Ala His 
1               5                   10                  15      


Leu Arg Ala Trp Thr Val Glu Arg Lys Arg Pro Gly Arg Leu Leu Arg 
            20                  25                  30          


Thr Asp Arg Gln Pro Leu Arg Glu Tyr Lys Leu Gly Arg Arg Ile Glu 
        35                  40                  45              


Ile Cys Leu Glu Pro Leu Gln Lys Gly Glu Asn Leu Gly Pro Gln Asp 
    50                  55                  60                  


Val Leu Leu Arg Thr Gln Val Arg Ile Pro Gly Glu Arg Thr Tyr Ala 
65                  70                  75                  80  


Pro Ala Leu Asp Leu Val Trp Asn Ala Ala Gln Gly Gly Thr Ala Gly 
                85                  90                  95      


Ser Leu Arg Gln Arg Val Ala Asp Phe Tyr Arg Leu Pro Val Glu Lys 
            100                 105                 110         


Ile Glu Ile Ala Lys Tyr Phe Pro Glu Lys Phe Glu Trp Leu Pro Ile 
        115                 120                 125             


Ser Ser Trp Asn Gln Gln Ile Thr Lys Arg Lys Lys Lys Lys Lys Gln 
    130                 135                 140                 


Asp Tyr Leu Gln Gly Ala Pro Tyr Tyr Leu Lys Asp Gly Asp Thr Ile 
145                 150                 155                 160 


Gly Val Lys Asn Leu Leu Ile Asp Asp Asp Asp Asp Phe Ser Thr Ile 
                165                 170                 175     


Arg Asp Asp Thr Gly Lys Glu Lys Gln Lys Gln Arg Ala Leu Gly Arg 
            180                 185                 190         


Arg Lys Ser Gln Glu Ala Leu His Glu Gln Ser Ser Tyr Ile Leu Ser 
        195                 200                 205             


Ser Ala Glu Thr Pro Ala Arg Pro Arg Ala Pro Glu Thr Ser Leu Ser 
    210                 215                 220                 


Ile His Val Gly Ser Phe Arg 
225                 230     


<210>  171
<211>  5376
<212>  DNA
<213>  Homosapiens

<400>  171
tattttctct tggcccagaa gagcttggtt tgtttgaaga taaggataaa cccgatgcaa     60

aggttcgaat catcccttta cagttacagc gcttgtttgc tcagcttctg ctcttagacc    120

aggaagctgc atccacagca gacctcactg acagctttgg gtggaccagt aatgaggaaa    180

tgaggcaaca tgatgtgcag gaactgaatc gaatcctctt cagcgctttg gaaacttctt    240

tagttgggac ctccggtcat gacctcatct atcgtctgta ccatggaacc attgttaacc    300

agattgtttg taaagaatgt aagaacgtta gcgagaggca ggaagacttc ttagatctaa    360

cagtagcagt caaaaatgta tccggtttgg aagatgctct ctggaacatg tatgtagaag    420

aggaagtttt tgattgtgac aacttgtacc actgtggaac ttgtgacagg ctggttaaag    480

cagcaaagtc ggccaaatta cgtaagctgc ctccttttct tactgtttca ttactaagat    540

ttaattttga ttttgtgaaa tgcgaacgct acaaggaaac tagctgttat acattccctc    600

tccggattaa tctcaagccc ttttgtgaac agagtgaatt ggatgactta gaatatatat    660

atgacctctt ctcagttatt atacacaaag gtggctgcta cggaggccat taccatgtat    720

atattaaaga tgttgatcat ttgggaaact ggcagtttca agaggaaaaa agtaaaccag    780

atgtgaatct gaaagatctc cagagtgaag aagagattga tcatccactg atgattctaa    840

aagcaatctt attagaggag aataatctaa ttcctgttga tcagctgggc cagaaacttt    900

tgaaaaagat aggaatatct tggaacaaga agtacagaaa acagcatgga ccactgcgga    960

agttcttaca gctccattct cagatatttc tactcagttc agatgaaagt acagttcgtc   1020

tcttgaagaa tagttctctc caggctgagt ctgatttcca aaggaatgac cagcaaattt   1080

tcaagatgct tcctccagaa tccccaggtt taaacaatag catctcctgt ccccactggt   1140

ttgatataaa tgattctaaa gtccagccaa tcagggaaaa ggatattgaa cagcaatttc   1200

agggtaaaga aagtgcctac atgttgtttt atcggaaatc ccagttgcag agaccccctg   1260

aagctcgagc taatccaaga tatggggttc catgtcattt actgaatgaa atggatgcag   1320

ctaacattga actgcaaacc aaaagggcag aatgtgattc tgcaaacaat acttttgaat   1380

tgcatcttca cctgggccct cagtatcatt tcttcaatgg ggctctgcac ccagtagtct   1440

ctcaaacaga aagcgtgtgg gatttgacct ttgataaaag aaaaacttta ggagatctcc   1500

ggcagtcaat atttcagctg ttagaatttt gggaaggaga catggttctt agtgttgcaa   1560

agcttgtacc agcaggactt cacatttacc agtcacttgg cggggatgaa ctgacactgt   1620

gtgaaactga aattgctgat ggggaagaca tctttgtgtg gaatggggtg gaggttggtg   1680

gagtccacat tcaaactggt attgactgcg aacctctact tttaaatgtt cttcatctag   1740

acacaagcag tgatggagaa aagtgttgtc aggtgataga atctccacat gtctttccag   1800

ctaatgcaga agtgggcact gtcctcacag ccttagcaat cccagcaggt gtcatcttca   1860

tcaacagtgc tggatgtcca ggtggggagg gttggacggc catccccaag gaagacatga   1920

ggaagacgtt cagggagcaa gggctcagaa atggaagctc aattttaatt caggattctc   1980

atgatgataa cagcttgttg accaaggaag agaaatgggt cactagtatg aatgagattg   2040

actggctcca cgttaaaaat ttatgccagt tagaatctga agagaagcaa gttaaaatat   2100

cagcaactgt taacacaatg gtgtttgata ttcgaattaa agccataaag gaattaaaat   2160

taatgaagga actagctgac aacagctgtt tgagacctat tgatagaaat gggaagcttc   2220

tttgtccagt gccggacagc tatactttga aggaagcaga attgaagatg ggaagttcat   2280

tgggactgtg tcttggaaaa gcaccaagtt cgtctcagtt gttcctgttt tttgcaatgg   2340

ggagtgacgt tcaacctggg acagaaatgg aaatcgtagt agaagaaaca atatctgtga   2400

gagattgttt aaagttaatg ctgaagaaat ctggcctaca aggagatgcc tggcatttac   2460

gaaaaatgga ttggtgctat gaagctggag agcctttatg tgaagaagat gcaacactga   2520

aagaacttct gatatgttct ggagatactt tgcttttaat tgaaggacaa cttcctcctc   2580

tgggtttcct gaaggtgccc atctggtggt accagcttca gggtccctca ggacactggg   2640

agagtcatca ggaccagacc aactgtactt cgtcttgggg cagagtttgg agagccactt   2700

ccagccaagg tgcttctggg aacgagcctg cgcaagtttc tctcctctac ttgggagaca   2760

tagagatctc agaagatgcc acgctggcgg agctgaagtc tcaggccatg accttgcctc   2820

ctttcctgga gttcggtgtc ccgtccccag cccacctcag agcctggacg gtggagagga   2880

agcgcccagg caggctttta cgaactgacc ggcagccact cagggaatat aaactaggac   2940

ggagaattga gatctgctta gagccccttc agaaaggcga aaacttgggc ccccaggacg   3000

tgctgctgag gacacaggtg cgcatccctg gtgagaggac ctatgcccct gccctggacc   3060

tggtgtggaa cgcggcccag ggtgggactg ccggctccct gaggcagaga gttgccgatt   3120

tctatcgtct tcccgtggag aagattgaaa ttgccaaata ctttcccgaa aagttcgagt   3180

ggcttccgat atctagctgg aaccaacaaa taaccaagag gaaaaagaaa aaaaaacaag   3240

attatttgca aggggcaccg tattacttga aagacggaga tactattggt gttaagaatc   3300

tcctgattga cgacgatgat gatttcagta caatcagaga tgacactgga aaagaaaagc   3360

agaaacaacg ggccctgggg agaaggaaaa gccaagaagc cctccatgag cagagcagct   3420

acatcctctc cagtgcagag acgcctgccc ggccccgagc cccggaaact tctctctcca   3480

tccacgtggg gagcttcaga taaccgcgcc gctgcacggc tctactcccg atgaactctc   3540

cggctgatgc cacaaacgtg ggtttcctgg gcatggggac tggctgcctg gcgcctccaa   3600

tcccaaatcc tctgcttcct ttgagcacag ggacggctcc tctgaggcct ggccagtgca   3660

tgtagtcact tagctctgca acacgtggca gccacggggg ctggtgcagc tctggatgtc   3720

gcccacccag ctgccagtag gtgctgggct ctctcacaca gcacccggcc ccagctgcct   3780

ttttttttct tttaaccaga aaatgcacaa cgtgtgcgtg aaccgcaggt atggaggcag   3840

cggcatgccg ttgctccgct gtgggaggtg tgtggggtca ggccagccac tttcctccgt   3900

gttcagatga ctctcgttcg ccctgaccgg cttctcacag tgtctcaggc cactgcgcca   3960

ccgcgctggt gctgagcaga agcgggcaga agtggggtct gctttcagga cttcatttcc   4020

cccactcgtt ccggccccgc atgctccacg tctgcccttt ggtctgagtt aaaactgcga   4080

tgctgaaaag tgcgagctct ttccacgagg aggagccaca cagggtggcc tccgagggtg   4140

agtcgctctg ctaagcaagg gcagccgctg cacgtcagcc cgcaggccaa gggtccagct   4200

tatcctgggt gctctgtgat cagaaggtcc ttggatcccg aggactgcag ctgctgccgt   4260

ccacagcgcc tcagcctctc ttcctgtgtg gaagcggggc aggcagggct gtggcagaca   4320

ggcctggcat agcccaggtt ccaggtgtcc tgggcagcct gaccggtttc ctgagtagcc   4380

tcaatgaaaa cacctgagaa aaagaaaatg taaactaagg aagggttttc ccacttaatc   4440

caacccagat ttctattcaa cttaaaggat ttaattggca tttgtgagaa ataatagtac   4500

ctgtgtcact gagttgattg atttgggaca tagacggttg actttcccag acagcagctt   4560

agcggaaagc agcatcccga agacggtgtc gcatgtcctg agcctgcttg tcacctgggc   4620

ctcacggttt ctcgtcagcc ccgtcactga tgggaagcag cactgaagtg tgagggcaga   4680

aaggacaccg ctggagtcag gcgctcccct gcctgtgacc cttttccaac aagctgatgc   4740

tgagccagcg gcctgctttg tccctcatac tcctcccaac agtccaaacc cctaccagac   4800

agaagccacg tcgcttctgc acacgtgtct gagagcgtct gccatagacg tctgtgcgtt   4860

tccgtgaagc actgcgccct aaggacccaa ctctgactag cagctgcctc ccactcccaa   4920

acactaaccc cgctcaggag actcgcactg ggtgtagact gcgtctttgc agagggagat   4980

gatagaggct tctgatgacg ccagagctgt aagtgtcgtg acgagctggg cgcccagccc   5040

ttcttaagct gttctgtttc tgtggcttta actgacatat ttctgtagca tctgccttca   5100

tctcatctca gcgtaatgaa atattaatga aatcgctgaa aagctttgcc ttcgagaggc   5160

cagaagcctc gcggaatgtc tgcaagtcca aagacgcgtg tgggttgtgc cctgaagtgc   5220

cgtccagcag gcgcgtgcgg ccgggccggc ctgtgcgtgt ggcctttgcc ttcttccctt   5280

tcttcctgtt ttctgttttt ttaatttggg gattgagaaa gctgtacgat tttgttaaag   5340

aaaaaaataa accatttttt aaagttgtag ccctta                             5376


<210>  172
<211>  1107
<212>  PRT
<213>  Homosapiens

<400>  172

Met Arg Gln His Asp Val Gln Glu Leu Asn Arg Ile Leu Phe Ser Ala 
1               5                   10                  15      


Leu Glu Thr Ser Leu Val Gly Thr Ser Gly His Asp Leu Ile Tyr Arg 
            20                  25                  30          


Leu Tyr His Gly Thr Ile Val Asn Gln Ile Val Cys Lys Glu Cys Lys 
        35                  40                  45              


Asn Val Ser Glu Arg Gln Glu Asp Phe Leu Asp Leu Thr Val Ala Val 
    50                  55                  60                  


Lys Asn Val Ser Gly Leu Glu Asp Ala Leu Trp Asn Met Tyr Val Glu 
65                  70                  75                  80  


Glu Glu Val Phe Asp Cys Asp Asn Leu Tyr His Cys Gly Thr Cys Asp 
                85                  90                  95      


Arg Leu Val Lys Ala Ala Lys Ser Ala Lys Leu Arg Lys Leu Pro Pro 
            100                 105                 110         


Phe Leu Thr Val Ser Leu Leu Arg Phe Asn Phe Asp Phe Val Lys Cys 
        115                 120                 125             


Glu Arg Tyr Lys Glu Thr Ser Cys Tyr Thr Phe Pro Leu Arg Ile Asn 
    130                 135                 140                 


Leu Lys Pro Phe Cys Glu Gln Ser Glu Leu Asp Asp Leu Glu Tyr Ile 
145                 150                 155                 160 


Tyr Asp Leu Phe Ser Val Ile Ile His Lys Gly Gly Cys Tyr Gly Gly 
                165                 170                 175     


His Tyr His Val Tyr Ile Lys Asp Val Asp His Leu Gly Asn Trp Gln 
            180                 185                 190         


Phe Gln Glu Glu Lys Ser Lys Pro Asp Val Asn Leu Lys Asp Leu Gln 
        195                 200                 205             


Ser Glu Glu Glu Ile Asp His Pro Leu Met Ile Leu Lys Ala Ile Leu 
    210                 215                 220                 


Leu Glu Glu Asn Asn Leu Ile Pro Val Asp Gln Leu Gly Gln Lys Leu 
225                 230                 235                 240 


Leu Lys Lys Ile Gly Ile Ser Trp Asn Lys Lys Tyr Arg Lys Gln His 
                245                 250                 255     


Gly Pro Leu Arg Lys Phe Leu Gln Leu His Ser Gln Ile Phe Leu Leu 
            260                 265                 270         


Ser Ser Asp Glu Ser Thr Val Arg Leu Leu Lys Asn Ser Ser Leu Gln 
        275                 280                 285             


Ala Glu Ser Asp Phe Gln Arg Asn Asp Gln Gln Ile Phe Lys Met Leu 
    290                 295                 300                 


Pro Pro Glu Ser Pro Gly Leu Asn Asn Ser Ile Ser Cys Pro His Trp 
305                 310                 315                 320 


Phe Asp Ile Asn Asp Ser Lys Val Gln Pro Ile Arg Glu Lys Asp Ile 
                325                 330                 335     


Glu Gln Gln Phe Gln Gly Lys Glu Ser Ala Tyr Met Leu Phe Tyr Arg 
            340                 345                 350         


Lys Ser Gln Leu Gln Arg Pro Pro Glu Ala Arg Ala Asn Pro Arg Tyr 
        355                 360                 365             


Gly Val Pro Cys His Leu Leu Asn Glu Met Asp Ala Ala Asn Ile Glu 
    370                 375                 380                 


Leu Gln Thr Lys Arg Ala Glu Cys Asp Ser Ala Asn Asn Thr Phe Glu 
385                 390                 395                 400 


Leu His Leu His Leu Gly Pro Gln Tyr His Phe Phe Asn Gly Ala Leu 
                405                 410                 415     


His Pro Val Val Ser Gln Thr Glu Ser Val Trp Asp Leu Thr Phe Asp 
            420                 425                 430         


Lys Arg Lys Thr Leu Gly Asp Leu Arg Gln Ser Ile Phe Gln Leu Leu 
        435                 440                 445             


Glu Phe Trp Glu Gly Asp Met Val Leu Ser Val Ala Lys Leu Val Pro 
    450                 455                 460                 


Ala Gly Leu His Ile Tyr Gln Ser Leu Gly Gly Asp Glu Leu Thr Leu 
465                 470                 475                 480 


Cys Glu Thr Glu Ile Ala Asp Gly Glu Asp Ile Phe Val Trp Asn Gly 
                485                 490                 495     


Val Glu Val Gly Gly Val His Ile Gln Thr Gly Ile Asp Cys Glu Pro 
            500                 505                 510         


Leu Leu Leu Asn Val Leu His Leu Asp Thr Ser Ser Asp Gly Glu Lys 
        515                 520                 525             


Cys Cys Gln Val Ile Glu Ser Pro His Val Phe Pro Ala Asn Ala Glu 
    530                 535                 540                 


Val Gly Thr Val Leu Thr Ala Leu Ala Ile Pro Ala Gly Val Ile Phe 
545                 550                 555                 560 


Ile Asn Ser Ala Gly Cys Pro Gly Gly Glu Gly Trp Thr Ala Ile Pro 
                565                 570                 575     


Lys Glu Asp Met Arg Lys Thr Phe Arg Glu Gln Gly Leu Arg Asn Gly 
            580                 585                 590         


Ser Ser Ile Leu Ile Gln Asp Ser His Asp Asp Asn Ser Leu Leu Thr 
        595                 600                 605             


Lys Glu Glu Lys Trp Val Thr Ser Met Asn Glu Ile Asp Trp Leu His 
    610                 615                 620                 


Val Lys Asn Leu Cys Gln Leu Glu Ser Glu Glu Lys Gln Val Lys Ile 
625                 630                 635                 640 


Ser Ala Thr Val Asn Thr Met Val Phe Asp Ile Arg Ile Lys Ala Ile 
                645                 650                 655     


Lys Glu Leu Lys Leu Met Lys Glu Leu Ala Asp Asn Ser Cys Leu Arg 
            660                 665                 670         


Pro Ile Asp Arg Asn Gly Lys Leu Leu Cys Pro Val Pro Asp Ser Tyr 
        675                 680                 685             


Thr Leu Lys Glu Ala Glu Leu Lys Met Gly Ser Ser Leu Gly Leu Cys 
    690                 695                 700                 


Leu Gly Lys Ala Pro Ser Ser Ser Gln Leu Phe Leu Phe Phe Ala Met 
705                 710                 715                 720 


Gly Ser Asp Val Gln Pro Gly Thr Glu Met Glu Ile Val Val Glu Glu 
                725                 730                 735     


Thr Ile Ser Val Arg Asp Cys Leu Lys Leu Met Leu Lys Lys Ser Gly 
            740                 745                 750         


Leu Gln Gly Asp Ala Trp His Leu Arg Lys Met Asp Trp Cys Tyr Glu 
        755                 760                 765             


Ala Gly Glu Pro Leu Cys Glu Glu Asp Ala Thr Leu Lys Glu Leu Leu 
    770                 775                 780                 


Ile Cys Ser Gly Asp Thr Leu Leu Leu Ile Glu Gly Gln Leu Pro Pro 
785                 790                 795                 800 


Leu Gly Phe Leu Lys Val Pro Ile Trp Trp Tyr Gln Leu Gln Gly Pro 
                805                 810                 815     


Ser Gly His Trp Glu Ser His Gln Asp Gln Thr Asn Cys Thr Ser Ser 
            820                 825                 830         


Trp Gly Arg Val Trp Arg Ala Thr Ser Ser Gln Gly Ala Ser Gly Asn 
        835                 840                 845             


Glu Pro Ala Gln Val Ser Leu Leu Tyr Leu Gly Asp Ile Glu Ile Ser 
    850                 855                 860                 


Glu Asp Ala Thr Leu Ala Glu Leu Lys Ser Gln Ala Met Thr Leu Pro 
865                 870                 875                 880 


Pro Phe Leu Glu Phe Gly Val Pro Ser Pro Ala His Leu Arg Ala Trp 
                885                 890                 895     


Thr Val Glu Arg Lys Arg Pro Gly Arg Leu Leu Arg Thr Asp Arg Gln 
            900                 905                 910         


Pro Leu Arg Glu Tyr Lys Leu Gly Arg Arg Ile Glu Ile Cys Leu Glu 
        915                 920                 925             


Pro Leu Gln Lys Gly Glu Asn Leu Gly Pro Gln Asp Val Leu Leu Arg 
    930                 935                 940                 


Thr Gln Val Arg Ile Pro Gly Glu Arg Thr Tyr Ala Pro Ala Leu Asp 
945                 950                 955                 960 


Leu Val Trp Asn Ala Ala Gln Gly Gly Thr Ala Gly Ser Leu Arg Gln 
                965                 970                 975     


Arg Val Ala Asp Phe Tyr Arg Leu Pro Val Glu Lys Ile Glu Ile Ala 
            980                 985                 990         


Lys Tyr Phe Pro Glu Lys Phe Glu  Trp Leu Pro Ile Ser  Ser Trp Asn 
        995                 1000                 1005             


Gln Gln  Ile Thr Lys Arg Lys  Lys Lys Lys Lys Gln  Asp Tyr Leu 
    1010                 1015                 1020             


Gln Gly  Ala Pro Tyr Tyr Leu  Lys Asp Gly Asp Thr  Ile Gly Val 
    1025                 1030                 1035             


Lys Asn  Leu Leu Ile Asp Asp  Asp Asp Asp Phe Ser  Thr Ile Arg 
    1040                 1045                 1050             


Asp Asp  Thr Gly Lys Glu Lys  Gln Lys Gln Arg Ala  Leu Gly Arg 
    1055                 1060                 1065             


Arg Lys  Ser Gln Glu Ala Leu  His Glu Gln Ser Ser  Tyr Ile Leu 
    1070                 1075                 1080             


Ser Ser  Ala Glu Thr Pro Ala  Arg Pro Arg Ala Pro  Glu Thr Ser 
    1085                 1090                 1095             


Leu Ser  Ile His Val Gly Ser  Phe Arg 
    1100                 1105         


<210>  173
<211>  628
<212>  DNA
<213>  Homosapiens

<400>  173
gagtcaaggg cataactgcc tacctcgagc ccgctctcct cctgccagct gccgggctat     60

caagccaggc ctctctcacc ctgtccctct ctgccacatc gtacctgctc aggccgccac    120

ctctttcctt ttctcccgca ctgaggaagt tccctaccac gtctgggggg gctctgctgt    180

gtaccgagaa tgggatcttc acttccgctc ttcattccaa gattaaagga aattgaaatg    240

cggaataaga gtttgccact agcatccagc atttagggaa aaatctctcc ttataaaaac    300

cagaaaagct ggaggagaag ctttgcccat tatgcctcaa gttaccacgt ggttttgttt    360

gtttgtttgg atctggcgct tgacggtttt ctggtacagc ccccaggacg tgctgctgag    420

gacacaggtg cgcatccctg gtgagaggac ctatgcccct gccctggacc tggtgtggaa    480

cgcggcccag ggtgggactg ccggctccct gaggcagaga gttgccgatt tctatcgtct    540

tcccgtggag aagattgaaa ttgccaaata ctttcccgaa aagttcgagt ggcttccgat    600

atctagctgg aaccaacaaa taaccaag                                       628


<210>  174
<211>  98
<212>  PRT
<213>  Homosapiens

<400>  174

Met Pro Gln Val Thr Thr Trp Phe Cys Leu Phe Val Trp Ile Trp Arg 
1               5                   10                  15      


Leu Thr Val Phe Trp Tyr Ser Pro Gln Asp Val Leu Leu Arg Thr Gln 
            20                  25                  30          


Val Arg Ile Pro Gly Glu Arg Thr Tyr Ala Pro Ala Leu Asp Leu Val 
        35                  40                  45              


Trp Asn Ala Ala Gln Gly Gly Thr Ala Gly Ser Leu Arg Gln Arg Val 
    50                  55                  60                  


Ala Asp Phe Tyr Arg Leu Pro Val Glu Lys Ile Glu Ile Ala Lys Tyr 
65                  70                  75                  80  


Phe Pro Glu Lys Phe Glu Trp Leu Pro Ile Ser Ser Trp Asn Gln Gln 
                85                  90                  95      


Ile Thr 
        


<210>  175
<211>  2209
<212>  DNA
<213>  Homosapiens

<400>  175
ctccaatacc taatatttaa aaattacctt ttggaaactg atttatagga catattttct     60

tccaggtatc ttacctttat attgcagaaa tccttaacca gaaacaaaca cttctgtttt    120

ctaaatgaaa caccattctt tctgattatc cgattctcat tttactcacg ggtttgatct    180

agttatattt tttccagctt tattttcaaa atttttccat ttttttgtga attttattgc    240

gataccaatt atgaaataaa atcttcagtt ctcatctctg tatcacctct taccattaga    300

tttaatttag tcatggatga gcctaattat tgatggtaat aacaatctca actttaaact    360

tggaagaagc tacttcttca tttatggatt gatttggatt atctggcttt taatctatat    420

aaacaacagc tctttgaaca agtcattttt attaagtagg aaactagact ttcatagctt    480

ccatttagca ttgttacata gaaaacagga agacaatatc ttaagagtat ggaaattgaa    540

aatcaaacct aatcttagtg catgtaatcc ttttgtctga agtgcaactc atttttcttc    600

tttcttgata ttcttgattt tcaaagaaat actgatttca gcatttattt ttcttagaga    660

gctaggaatt aataaccttc atcatattat caaaattttt ttaagtgccg gacagctata    720

ctttgaagga agcagaattg aagatgggaa gttcattggg actgtgtctt ggaaaagcac    780

caagttcgtc tcagttgttc ctgttttttg caatggggag tgacgttcaa cctgggacag    840

aaatggaaat cgtagtagaa gaaacaatat ctgtgagaga ttgtttaaag ttaatgctga    900

agaaatctgg cctacaagga gatgcctggc atttacgaaa aatggattgg tgctatgaag    960

ctggagagcc tttatgtgaa gaagatgcaa cactgaaaga acttctgata tgttctggag   1020

atactttgct tttaattgaa ggacaacttc ctcctctggg tttcctgaag gtgcccatct   1080

ggtggtacca gcttcagggt ccctcaggac actgggagag tcatcaggac cagaccaact   1140

gtacttcgtc ttggggcaga gtttggagag ccacttccag ccaaggtgag aacagaatgg   1200

gatttcagca gccagtgcat cataaagaga agtaaattga ctgcctgtgc tctgagagtc   1260

aattgatata tttattttta aaacgtaaga tcttgaaaat caagacctat taatttcata   1320

agtcattcca gacatcacat aataataaca ctgtgccatt tctgtacgtg ctctgtaacc   1380

tctgtaaagc actatatatc ttgttgttta ttattatatc aatatattac actttccaaa   1440

gacttttatg tatcatctct caagatcctc agggcaacag gggccccatt tatcaccacg   1500

taccagaata ttgagacttc atccaattct aatgatgtca ttttagccca caggggcaga   1560

gaccaggagt ccacatccta catgtcttcc aatctttctg cctcaaaacc ctcaggaact   1620

gcttctaggg catttgatat catctcactg acttctgaga aggaacatag acaagtacaa   1680

gcatgttgtc ttactcagca ctcagccgca cacatcacga tgggcagaag tcactatcag   1740

tgagttctgt tgcccttgta caaagaggag ttccacttca ttataaagaa atggagcgag   1800

tatattttta ataggcccaa ctctttagct atgtttttct ttttatcagg ctttacttat   1860

ttagtttttc tagtgccttg aagtatatta cttatatttc tttttaatct tttcagcctc   1920

agtaataaaa ttaatataaa tgagtcaaat tcttatctcc ttattctttg aagttaggat   1980

tatatagaga gagtaatgtt gaatgagcta taaaattggc ataaagttac tttttagttg   2040

ggttacagta gttcatgtta actaatgcta aaaatgcctt ggtgatagaa ttctagttac   2100

atatagaatt ggatatagat tgtaaaagca tgtttaatca gtatgtttct acgtgaaaag   2160

taaataaaag gttctttttt tggtaataca tctgtacaca acacatggg               2209


<210>  176
<211>  163
<212>  PRT
<213>  Homosapiens

<400>  176

Met Gly Ser Ser Leu Gly Leu Cys Leu Gly Lys Ala Pro Ser Ser Ser 
1               5                   10                  15      


Gln Leu Phe Leu Phe Phe Ala Met Gly Ser Asp Val Gln Pro Gly Thr 
            20                  25                  30          


Glu Met Glu Ile Val Val Glu Glu Thr Ile Ser Val Arg Asp Cys Leu 
        35                  40                  45              


Lys Leu Met Leu Lys Lys Ser Gly Leu Gln Gly Asp Ala Trp His Leu 
    50                  55                  60                  


Arg Lys Met Asp Trp Cys Tyr Glu Ala Gly Glu Pro Leu Cys Glu Glu 
65                  70                  75                  80  


Asp Ala Thr Leu Lys Glu Leu Leu Ile Cys Ser Gly Asp Thr Leu Leu 
                85                  90                  95      


Leu Ile Glu Gly Gln Leu Pro Pro Leu Gly Phe Leu Lys Val Pro Ile 
            100                 105                 110         


Trp Trp Tyr Gln Leu Gln Gly Pro Ser Gly His Trp Glu Ser His Gln 
        115                 120                 125             


Asp Gln Thr Asn Cys Thr Ser Ser Trp Gly Arg Val Trp Arg Ala Thr 
    130                 135                 140                 


Ser Ser Gln Gly Glu Asn Arg Met Gly Phe Gln Gln Pro Val His His 
145                 150                 155                 160 


Lys Glu Lys 
            


<210>  177
<211>  543
<212>  DNA
<213>  Homosapiens

<400>  177
tattttctct tggcccagaa gagcttggtt tgtttgaaga taaggataaa cccgatgcaa     60

aggttcgaat catcccttta cagttacagc gcttgtttgc tcagcttctg ctcttagacc    120

aggaagctgc atccacagca gacctcactg acagctttgg gtggaccagt aatgaggaaa    180

tgaggcaaca tgatgtgcag gaactgaatc gaatcctctt cagcgctttg gaaacttctt    240

tagttgggac ctccggtcat gacctcatct atcgtctgta ccatggaacc attgttaacc    300

agattgtttg taaagaatgt aagaacgtta gcgagaggca ggaagacttc ttagatctaa    360

cagtagcagt caaaaatgta tccggtttgg aagatgctct ctggaacatg tatgtagaag    420

aggaagtttt tgattgtgac aacttgtacc actgtggaac ttgtgacagg ctggttaaag    480

cagcaaaggt aaagacagat aactgctttt tcccagggtc cccactttgt agttagtaca    540

agt                                                                  543


<210>  178
<211>  118
<212>  PRT
<213>  Homosapiens

<400>  178

Met Arg Gln His Asp Val Gln Glu Leu Asn Arg Ile Leu Phe Ser Ala 
1               5                   10                  15      


Leu Glu Thr Ser Leu Val Gly Thr Ser Gly His Asp Leu Ile Tyr Arg 
            20                  25                  30          


Leu Tyr His Gly Thr Ile Val Asn Gln Ile Val Cys Lys Glu Cys Lys 
        35                  40                  45              


Asn Val Ser Glu Arg Gln Glu Asp Phe Leu Asp Leu Thr Val Ala Val 
    50                  55                  60                  


Lys Asn Val Ser Gly Leu Glu Asp Ala Leu Trp Asn Met Tyr Val Glu 
65                  70                  75                  80  


Glu Glu Val Phe Asp Cys Asp Asn Leu Tyr His Cys Gly Thr Cys Asp 
                85                  90                  95      


Arg Leu Val Lys Ala Ala Lys Val Lys Thr Asp Asn Cys Phe Phe Pro 
            100                 105                 110         


Gly Ser Pro Leu Cys Ser 
        115             


<210>  179
<211>  351
<212>  DNA
<213>  Homosapiens

<400>  179
tattttctct tggcccagaa gagcttggtt tgtttgaaga taaggataaa cccgatgcaa     60

agaaagtgac ttggcctata ccctatgggt aatggaattt gccttccgag aaagaatcag    120

ttttccaagt acaatactgc tactgcttta taaacatgta acactcttta ctatgcttat    180

tctttcttct ggtgaaggaa atatttgcag aacatccaca ttagcttccc ccagaagtct    240

atttaaagca ctttttttgc aacaataccg acctctccac cccacacaaa aaaaaataga    300

ggctagtatt ctttcaattt ggtactctgg aaataaattg agtaatgagt t             351


<210>  180
<211>  85
<212>  PRT
<213>  Homosapiens

<400>  180

Met Glu Phe Ala Phe Arg Glu Arg Ile Ser Phe Pro Ser Thr Ile Leu 
1               5                   10                  15      


Leu Leu Leu Tyr Lys His Val Thr Leu Phe Thr Met Leu Ile Leu Ser 
            20                  25                  30          


Ser Gly Glu Gly Asn Ile Cys Arg Thr Ser Thr Leu Ala Ser Pro Arg 
        35                  40                  45              


Ser Leu Phe Lys Ala Leu Phe Leu Gln Gln Tyr Arg Pro Leu His Pro 
    50                  55                  60                  


Thr Gln Lys Lys Ile Glu Ala Ser Ile Leu Ser Ile Trp Tyr Ser Gly 
65                  70                  75                  80  


Asn Lys Leu Ser Asn 
                85  


<210>  181
<211>  426
<212>  DNA
<213>  Homosapiens

<400>  181
cggggcatcc tgggaagcat agtccacgat ccataaatca ctttctggag acccgccctc     60

gccaacatgg cggcgcccag ttggggcggg ttcgttcgct tcgcgttttg gccagggcgg    120

gggtctgggc tttaggcagg tagtatttag tttcacaatg tttggggacc tgtttgaaga    180

ggagtattcc actgtgtcta ataatcagta tggaaaaggg aagaaattaa agactaaagc    240

tttggagcca cctgctccta gagaattcac caatttaagc ggaatcagaa atcagggtgg    300

aacctgttac ctcaattccc ttcttcagac tcttcatttc acacctgaat tcagagaagc    360

tctattttct cttggcccag aagagcttgg tttgtttgaa gataaggata aacccgatgc    420

aaaggt                                                               426


<210>  182
<211>  88
<212>  PRT
<213>  Homosapiens

<400>  182

Met Phe Gly Asp Leu Phe Glu Glu Glu Tyr Ser Thr Val Ser Asn Asn 
1               5                   10                  15      


Gln Tyr Gly Lys Gly Lys Lys Leu Lys Thr Lys Ala Leu Glu Pro Pro 
            20                  25                  30          


Ala Pro Arg Glu Phe Thr Asn Leu Ser Gly Ile Arg Asn Gln Gly Gly 
        35                  40                  45              


Thr Cys Tyr Leu Asn Ser Leu Leu Gln Thr Leu His Phe Thr Pro Glu 
    50                  55                  60                  


Phe Arg Glu Ala Leu Phe Ser Leu Gly Pro Glu Glu Leu Gly Leu Phe 
65                  70                  75                  80  


Glu Asp Lys Asp Lys Pro Asp Ala 
                85              


<210>  183
<211>  2407
<212>  DNA
<213>  Homosapiens

<400>  183
cttccgccta ctgtatcata gcagcttaga atcccagctg ctggctcggg ctgcagttct     60

ctcatggctc gcacagggtg gaccagcccc attcccctat gtgtttctct gctgctgacc    120

tgtggctttg ctgaggcagg gaagctgctg gtagtgccca tggatgggag tcactggttc    180

accatgcagt cggtggtgga gaaacttatc ctcagggggc atgaggtggt tgtagtcatg    240

ccagaggtga gttggcaact gggaaaatca ctgaattgca cagtgaagac ttactcaacc    300

tcatacactc tggaggatct ggaccgggaa ttcatggatt tcgccgatgc tcaatggaaa    360

gcacaagtac gaagtttgtt ttctctattt ctgagttcat ccaatggttt ttttaactta    420

tttttttcgc attgcaggag tttgtttaat gaccgaaaat tagtagaata cttaaaggag    480

agttcttttg atgcggtgtt tcttgatcct tttgatgcct gtggcttaat tgttgccaaa    540

tatttctccc tcccctctgt ggtcttcgcc aggggaatag cttgccacta tcttgaagaa    600

ggtgcacagt gccctgctcc tctttcctat gtccccagaa ttctcttagg gttctcagat    660

gccatgactt tcaaggagag agtacggaac cacatcatgc acttggagga acatttattt    720

tgccagtatt tttccaaaaa tgccctagaa atagcctctg aaattctcca aacacctgtc    780

acagcatatg atctctacag ccacacatca atttggttgt tgcgaacaga ctttgttttg    840

gactatccca aacccgtgat gcccaatatg atcttcattg gtggtatcaa ctgccatcag    900

ggaaagccat tgcctatgga atttgaagcc tacattaatg cttctggaga acatggaatt    960

gtggttttct ctttgggatc aatggtctca gaaattccag agaagaaagc tatggcaatt   1020

gctgatgctt tgggcaaaat ccctcagaca gtcctgtggc ggtacactgg aacccgacca   1080

tcgaatcttg cgaacaacac gatacttgtt aagtggctac cccaaaacga tctgcttggt   1140

cacccgatga cccgtgcctt tatcacccat gctggttccc atggtgttta tgaaagcata   1200

tgcaatggcg ttcccatggt gatgatgccc ttgtttggtg atcagatgga caatgcaaag   1260

cgcatggaga ctaagggagc tggagtgacc ctgaatgttc tggaaatgac ttctgaagat   1320

ttagaaaatg ctctaaaagc agtcatcaat gacaaaagtt acaaggagaa catcatgcgc   1380

ctctccagcc ttcacaagga ccgcccggtg gagccgctgg acctggccgt gttctgggtg   1440

gagtttgtga tgaggcacaa gggcgcgcca cacctgcgcc ccgcagccca cgacctcacc   1500

tggtaccagt accattcctt ggacgtgatt ggtttcctct tggccgtcgt gctgacagtg   1560

gccttcatca cctttaaatg ttgtgcttat ggctaccgga aatgcttggg gaaaaaaggg   1620

cgagttaaga aagcccacaa atccaagacc cattgagaag tgggtgggaa ataaggtaaa   1680

attttgaacc attccctagt catttccaaa cttgaaaaca gaatcagtgt taaattcatt   1740

ttattcttat taaggaaata ctttgcataa attaatcagc cccagagtgc tttaaaaaat   1800

tctcttaaat aaaaataata gactcgctag tcagtaaaga tatttgaata tgtatcgtgc   1860

cccctctggt gtctttgatc aggatgacat gtgccatttt tcagaggacg tgcagacagg   1920

ctggcattct agattacttt tcttactctg aaacatggcc tgtttgggag tgcgggattc   1980

aaaggtggtc ccacggctgc ccctactgca aatggcagtt ttaatcttat cttttggctt   2040

ctgcagatgg ttgcaattga tccttaacca ataatggtca gtcctcatct ctgtcgtgct   2100

tcataggtgc caccttgtgt gtttaaagaa gggaagcttt gtacctttag agtgtaggtg   2160

aaatgaatga atggcttgga gtgcactgag aacagcatat gatttcttgc tttggggaaa   2220

aagaatgatg ctatgaaatt ggtgggtggt gtatttgaga agataatcat tgcttatgtc   2280

aaatggagct gaatttgata aaaacccaaa atacagctat gaagtgctgg gcaagtttac   2340

tttttttctg atgtttccta caactaaaaa taaattaata aatttatata aattctattt   2400

aagtgtt                                                             2407


<210>  184
<211>  530
<212>  PRT
<213>  Homosapiens

<400>  184

Met Ala Arg Thr Gly Trp Thr Ser Pro Ile Pro Leu Cys Val Ser Leu 
1               5                   10                  15      


Leu Leu Thr Cys Gly Phe Ala Glu Ala Gly Lys Leu Leu Val Val Pro 
            20                  25                  30          


Met Asp Gly Ser His Trp Phe Thr Met Gln Ser Val Val Glu Lys Leu 
        35                  40                  45              


Ile Leu Arg Gly His Glu Val Val Val Val Met Pro Glu Val Ser Trp 
    50                  55                  60                  


Gln Leu Gly Lys Ser Leu Asn Cys Thr Val Lys Thr Tyr Ser Thr Ser 
65                  70                  75                  80  


Tyr Thr Leu Glu Asp Leu Asp Arg Glu Phe Met Asp Phe Ala Asp Ala 
                85                  90                  95      


Gln Trp Lys Ala Gln Val Arg Ser Leu Phe Ser Leu Phe Leu Ser Ser 
            100                 105                 110         


Ser Asn Gly Phe Phe Asn Leu Phe Phe Ser His Cys Arg Ser Leu Phe 
        115                 120                 125             


Asn Asp Arg Lys Leu Val Glu Tyr Leu Lys Glu Ser Ser Phe Asp Ala 
    130                 135                 140                 


Val Phe Leu Asp Pro Phe Asp Ala Cys Gly Leu Ile Val Ala Lys Tyr 
145                 150                 155                 160 


Phe Ser Leu Pro Ser Val Val Phe Ala Arg Gly Ile Ala Cys His Tyr 
                165                 170                 175     


Leu Glu Glu Gly Ala Gln Cys Pro Ala Pro Leu Ser Tyr Val Pro Arg 
            180                 185                 190         


Ile Leu Leu Gly Phe Ser Asp Ala Met Thr Phe Lys Glu Arg Val Arg 
        195                 200                 205             


Asn His Ile Met His Leu Glu Glu His Leu Phe Cys Gln Tyr Phe Ser 
    210                 215                 220                 


Lys Asn Ala Leu Glu Ile Ala Ser Glu Ile Leu Gln Thr Pro Val Thr 
225                 230                 235                 240 


Ala Tyr Asp Leu Tyr Ser His Thr Ser Ile Trp Leu Leu Arg Thr Asp 
                245                 250                 255     


Phe Val Leu Asp Tyr Pro Lys Pro Val Met Pro Asn Met Ile Phe Ile 
            260                 265                 270         


Gly Gly Ile Asn Cys His Gln Gly Lys Pro Leu Pro Met Glu Phe Glu 
        275                 280                 285             


Ala Tyr Ile Asn Ala Ser Gly Glu His Gly Ile Val Val Phe Ser Leu 
    290                 295                 300                 


Gly Ser Met Val Ser Glu Ile Pro Glu Lys Lys Ala Met Ala Ile Ala 
305                 310                 315                 320 


Asp Ala Leu Gly Lys Ile Pro Gln Thr Val Leu Trp Arg Tyr Thr Gly 
                325                 330                 335     


Thr Arg Pro Ser Asn Leu Ala Asn Asn Thr Ile Leu Val Lys Trp Leu 
            340                 345                 350         


Pro Gln Asn Asp Leu Leu Gly His Pro Met Thr Arg Ala Phe Ile Thr 
        355                 360                 365             


His Ala Gly Ser His Gly Val Tyr Glu Ser Ile Cys Asn Gly Val Pro 
    370                 375                 380                 


Met Val Met Met Pro Leu Phe Gly Asp Gln Met Asp Asn Ala Lys Arg 
385                 390                 395                 400 


Met Glu Thr Lys Gly Ala Gly Val Thr Leu Asn Val Leu Glu Met Thr 
                405                 410                 415     


Ser Glu Asp Leu Glu Asn Ala Leu Lys Ala Val Ile Asn Asp Lys Ser 
            420                 425                 430         


Tyr Lys Glu Asn Ile Met Arg Leu Ser Ser Leu His Lys Asp Arg Pro 
        435                 440                 445             


Val Glu Pro Leu Asp Leu Ala Val Phe Trp Val Glu Phe Val Met Arg 
    450                 455                 460                 


His Lys Gly Ala Pro His Leu Arg Pro Ala Ala His Asp Leu Thr Trp 
465                 470                 475                 480 


Tyr Gln Tyr His Ser Leu Asp Val Ile Gly Phe Leu Leu Ala Val Val 
                485                 490                 495     


Leu Thr Val Ala Phe Ile Thr Phe Lys Cys Cys Ala Tyr Gly Tyr Arg 
            500                 505                 510         


Lys Cys Leu Gly Lys Lys Gly Arg Val Lys Lys Ala His Lys Ser Lys 
        515                 520                 525             


Thr His 
    530 


<210>  185
<211>  2413
<212>  DNA
<213>  Homosapiens

<400>  185
gtacttcttc cgcctactgt atcatagcag cttagaatcc cagctgctgg ctcgggctgc     60

agttctctca tggctcgcgc agggtggacc agccccgttc ctttatgtgt gtgtctactg    120

ctgacctgtg gctttgccga ggcagggaag ctgctggtag tgcccatgga tgggagtcac    180

tggttcacca tgcagtcggt ggtggagaaa cttatcctca gggggcatga ggtggttgta    240

gtcatgccag aggtgagttg gcaactggaa agatcactga attgcacagt gaagacttac    300

tcaacctcgt acactctgga agatcagaac cgggaattca tggttttcgc ccatgctcaa    360

tggaaagcac aggcacaaag tatattttct ctattaatga gttcatccag tggttttctt    420

gacttatttt tttcgcattg caggagtttg tttaatgacc gaaaattagt agaatactta    480

aaggagagtt cttttgatgc agtgtttctg gatccttttg atacctgtgg cttaattgtt    540

gctaaatatt tctccctccc ctctgtggtc ttcaccaggg gaatattttg ccaccatctt    600

gaagaaggtg cacagtgccc tgctcctctt tcctatgtcc ccaatgatct cttagggttc    660

tcagatgcca tgactttcaa ggagagagta tggaaccaca tcgtgcactt ggaggaccat    720

ttattttgcc agtatctttt tagaaatgcc ctagaaatag cctctgaaat tctccaaacc    780

cctgtcacgg catatgatct ctacagtcac acatcaattt ggttgttgcg aacggacttt    840

gttttggact atcccaaacc cgtgatgccc aacatgatct tcattggtgg tatcaactgt    900

catcagggaa agccattgcc tatggaattt gaagcctaca ttaatgcttc tggagaacat    960

ggaattgtgg ttttctcttt gggatcaatg gtctcagaaa ttccagagaa gaaagctatg   1020

gcaattgctg atgctttggg caaaatccct cagacagtcc tgtggcggta cactggaacc   1080

cgaccatcga atcttgcgaa caacacgata cttgttaagt ggctacccca aaacgatctg   1140

cttggtcacc cgatgacccg tgcctttatc acccatgctg gttcccatgg tgtttatgaa   1200

agcatatgca atggcgttcc catggtgatg atgcccttgt ttggtgatca gatggacaat   1260

gcaaagcgca tggagactaa gggagctgga gtgaccctga atgttctgga aatgacttct   1320

gaagatttag aaaatgctct aaaagcagtc atcaatgaca aaagttacaa ggagaacatc   1380

atgcgcctct ccagccttca caaggaccgc ccggtggagc cgctggacct ggccgtgttc   1440

tgggtggagt ttgtgatgag gcacaagggc gcgccacacc tgcgccccgc agcccacgac   1500

ctcacctggt accagtacca ttccttggac gtgattggtt tcctcttggc cgtcgtgctg   1560

acagtggcct tcatcacctt taaatgttgt gcttatggct accggaaatg cttggggaaa   1620

aaagggcgag ttaagaaagc ccacaaatcc aagacccatt gagaagtggg tgggaaataa   1680

ggtaaaattt tgaaccattc cctagtcatt tccaaacttg aaaacagaat cagtgttaaa   1740

ttcattttat tcttattaag gaaatacttt gcataaatta atcagcccca gagtgcttta   1800

aaaaattctc ttaaataaaa ataatagact cgctagtcag taaagatatt tgaatatgta   1860

tcgtgccccc tctggtgtct ttgatcagga tgacatgtgc catttttcag aggacgtgca   1920

gacaggctgg cattctagat tacttttctt actctgaaac atggcctgtt tgggagtgcg   1980

ggattcaaag gtggtcccac ggctgcccct actgcaaatg gcagttttaa tcttatcttt   2040

tggcttctgc agatggttgc aattgatcct taaccaataa tggtcagtcc tcatctctgt   2100

cgtgcttcat aggtgccacc ttgtgtgttt aaagaaggga agctttgtac ctttagagtg   2160

taggtgaaat gaatgaatgg cttggagtgc actgagaaca gcatatgatt tcttgctttg   2220

gggaaaaaga atgatgctat gaaattggtg ggtggtgtat ttgagaagat aatcattgct   2280

tatgtcaaat ggagctgaat ttgataaaaa cccaaaatac agctatgaag tgctgggcaa   2340

gtttactttt tttctgatgt ttcctacaac taaaaataaa ttaataaatt tatataaatt   2400

ctatttaagt gtt                                                      2413


<210>  186
<211>  530
<212>  PRT
<213>  Homosapiens

<400>  186

Met Ala Arg Ala Gly Trp Thr Ser Pro Val Pro Leu Cys Val Cys Leu 
1               5                   10                  15      


Leu Leu Thr Cys Gly Phe Ala Glu Ala Gly Lys Leu Leu Val Val Pro 
            20                  25                  30          


Met Asp Gly Ser His Trp Phe Thr Met Gln Ser Val Val Glu Lys Leu 
        35                  40                  45              


Ile Leu Arg Gly His Glu Val Val Val Val Met Pro Glu Val Ser Trp 
    50                  55                  60                  


Gln Leu Glu Arg Ser Leu Asn Cys Thr Val Lys Thr Tyr Ser Thr Ser 
65                  70                  75                  80  


Tyr Thr Leu Glu Asp Gln Asn Arg Glu Phe Met Val Phe Ala His Ala 
                85                  90                  95      


Gln Trp Lys Ala Gln Ala Gln Ser Ile Phe Ser Leu Leu Met Ser Ser 
            100                 105                 110         


Ser Ser Gly Phe Leu Asp Leu Phe Phe Ser His Cys Arg Ser Leu Phe 
        115                 120                 125             


Asn Asp Arg Lys Leu Val Glu Tyr Leu Lys Glu Ser Ser Phe Asp Ala 
    130                 135                 140                 


Val Phe Leu Asp Pro Phe Asp Thr Cys Gly Leu Ile Val Ala Lys Tyr 
145                 150                 155                 160 


Phe Ser Leu Pro Ser Val Val Phe Thr Arg Gly Ile Phe Cys His His 
                165                 170                 175     


Leu Glu Glu Gly Ala Gln Cys Pro Ala Pro Leu Ser Tyr Val Pro Asn 
            180                 185                 190         


Asp Leu Leu Gly Phe Ser Asp Ala Met Thr Phe Lys Glu Arg Val Trp 
        195                 200                 205             


Asn His Ile Val His Leu Glu Asp His Leu Phe Cys Gln Tyr Leu Phe 
    210                 215                 220                 


Arg Asn Ala Leu Glu Ile Ala Ser Glu Ile Leu Gln Thr Pro Val Thr 
225                 230                 235                 240 


Ala Tyr Asp Leu Tyr Ser His Thr Ser Ile Trp Leu Leu Arg Thr Asp 
                245                 250                 255     


Phe Val Leu Asp Tyr Pro Lys Pro Val Met Pro Asn Met Ile Phe Ile 
            260                 265                 270         


Gly Gly Ile Asn Cys His Gln Gly Lys Pro Leu Pro Met Glu Phe Glu 
        275                 280                 285             


Ala Tyr Ile Asn Ala Ser Gly Glu His Gly Ile Val Val Phe Ser Leu 
    290                 295                 300                 


Gly Ser Met Val Ser Glu Ile Pro Glu Lys Lys Ala Met Ala Ile Ala 
305                 310                 315                 320 


Asp Ala Leu Gly Lys Ile Pro Gln Thr Val Leu Trp Arg Tyr Thr Gly 
                325                 330                 335     


Thr Arg Pro Ser Asn Leu Ala Asn Asn Thr Ile Leu Val Lys Trp Leu 
            340                 345                 350         


Pro Gln Asn Asp Leu Leu Gly His Pro Met Thr Arg Ala Phe Ile Thr 
        355                 360                 365             


His Ala Gly Ser His Gly Val Tyr Glu Ser Ile Cys Asn Gly Val Pro 
    370                 375                 380                 


Met Val Met Met Pro Leu Phe Gly Asp Gln Met Asp Asn Ala Lys Arg 
385                 390                 395                 400 


Met Glu Thr Lys Gly Ala Gly Val Thr Leu Asn Val Leu Glu Met Thr 
                405                 410                 415     


Ser Glu Asp Leu Glu Asn Ala Leu Lys Ala Val Ile Asn Asp Lys Ser 
            420                 425                 430         


Tyr Lys Glu Asn Ile Met Arg Leu Ser Ser Leu His Lys Asp Arg Pro 
        435                 440                 445             


Val Glu Pro Leu Asp Leu Ala Val Phe Trp Val Glu Phe Val Met Arg 
    450                 455                 460                 


His Lys Gly Ala Pro His Leu Arg Pro Ala Ala His Asp Leu Thr Trp 
465                 470                 475                 480 


Tyr Gln Tyr His Ser Leu Asp Val Ile Gly Phe Leu Leu Ala Val Val 
                485                 490                 495     


Leu Thr Val Ala Phe Ile Thr Phe Lys Cys Cys Ala Tyr Gly Tyr Arg 
            500                 505                 510         


Lys Cys Leu Gly Lys Lys Gly Arg Val Lys Lys Ala His Lys Ser Lys 
        515                 520                 525             


Thr His 
    530 


<210>  187
<211>  2086
<212>  DNA
<213>  Homosapiens

<400>  187
atcatagcag cttagaatcc cagctgctgg ctcgggctgc agttctctca tggctcgcgc     60

agggtggacc agccccgttc ctttatgtgt gtgtctactg ctgacctgtg gctttgccga    120

ggcagggaag ctgctggtag tgcccatgga tgggagtcac tggttcacca tgcagtcggt    180

ggtggagaaa cttatcctca gggggcatga ggtggttgta gtcatgccag aggtgagttg    240

gcaactggaa agatcactga attgcacagt gaagacttac tcaacctcgt acactctgga    300

agatcagaac cgggaattca tggttttcgc ccatgctcaa tggaaagcac aggcacaaag    360

tatattttct ctattaatga gttcatccag tggttttctt gacttatttt tttcgcattg    420

caggagtttg tttaatgacc gaaaattagt agaatactta aaggagagtt cttttgatgc    480

agtgtttctg gatccttttg atacctgtgg cttaattgtt gctaaatatt tctccctccc    540

ctctgtggtc ttcaccaggg gaatattttg ccaccatctt gaagaaggtg cacagtgccc    600

tgctcctctt tcctatgtcc ccaatgatct cttagggttc tcagatgcca tgactttcaa    660

ggagagagta tggaaccaca tcgtgcactt ggaggaccat ttattttgcc agtatctttt    720

tagaaatgcc ctagaaatag cctctgaaat tctccaaacc cctgtcacgg catatgatct    780

ctacagtcac acatcaattt ggttgttgcg aacggacttt gttttggact atcccaaacc    840

cgtgatgccc aacatgatct tcattggtgg tatcaactgt catcagggaa agccattgcc    900

tatggaattt gaagcctaca ttaatgcttc tggagaacat ggaattgtgg ttttctcttt    960

gggatcaatg gtctcagaaa ttccagagaa gaaagctatg gcaattgctg atgctttggg   1020

caaaatccct cagacagtcc tgtggcggta cactggaacc cgaccatcga atcttgcgaa   1080

caacacgata cttgttaagt ggctacccca aaacgatctg cttggtcacc cgatgacccg   1140

tgcctttatc acccatgctg gttcccatgg tgtttatgaa agcatatgca atggcgttcc   1200

catggtgatg atgcccttgt ttggtgatca gatggacaat gcaaagcgca tggagactaa   1260

gggagctgga gtgaccctga atgttctgga aatgacttct gaagatttag aaaatgctct   1320

aaaagcagtc atcaatgaca aaagaaagaa gcagcagtca ggaagacaga tgtgaagagc   1380

tggagcatgt tcagatgaga ggagacggaa cacggggaca caccagcttg agcaagggac   1440

aacaggggag gactgatgac tgacttccca cctttgaggt gctaatgtgt gtgtggtggc   1500

actggataaa agatcaatgt tggctaggca ccatggcaca cgcctgtagt cccagccact   1560

ctggaggcta aggcgggagg attgcttgag cccagaagtt ggaggctgct atgagccgtg   1620

atcatgccac tgcactccag caacctgggc aacagagtga gaccctgtct caaaaaaaaa   1680

aaaaaaaatg aaaagtccac ataacctgag catcatgtgc ccagagcgtt gggtggtgtg   1740

gtcccattcc ttccttccag cggcttcttc tggccacctc aatgtcagga tgtcctgctc   1800

acatatcaat accattaaaa cctgacttct ttccctgcac tgttgaagct ccttcttgag   1860

gctcacatta tggatataat tttgattctt tcttcagtgg tatagataac tacttgtaac   1920

ctaagaacaa cttggtgaaa gtcctctaat acattatttt ttaaaaaaac acaaatcaat   1980

gagctcaact tattaactaa ctttcatcta ttcatttttg agccatccct gtctgattgt   2040

gaatctccat gattccaaca ctctgagctg gggatagtgc ctacac                  2086


<210>  188
<211>  441
<212>  PRT
<213>  Homosapiens

<400>  188

Met Ala Arg Ala Gly Trp Thr Ser Pro Val Pro Leu Cys Val Cys Leu 
1               5                   10                  15      


Leu Leu Thr Cys Gly Phe Ala Glu Ala Gly Lys Leu Leu Val Val Pro 
            20                  25                  30          


Met Asp Gly Ser His Trp Phe Thr Met Gln Ser Val Val Glu Lys Leu 
        35                  40                  45              


Ile Leu Arg Gly His Glu Val Val Val Val Met Pro Glu Val Ser Trp 
    50                  55                  60                  


Gln Leu Glu Arg Ser Leu Asn Cys Thr Val Lys Thr Tyr Ser Thr Ser 
65                  70                  75                  80  


Tyr Thr Leu Glu Asp Gln Asn Arg Glu Phe Met Val Phe Ala His Ala 
                85                  90                  95      


Gln Trp Lys Ala Gln Ala Gln Ser Ile Phe Ser Leu Leu Met Ser Ser 
            100                 105                 110         


Ser Ser Gly Phe Leu Asp Leu Phe Phe Ser His Cys Arg Ser Leu Phe 
        115                 120                 125             


Asn Asp Arg Lys Leu Val Glu Tyr Leu Lys Glu Ser Ser Phe Asp Ala 
    130                 135                 140                 


Val Phe Leu Asp Pro Phe Asp Thr Cys Gly Leu Ile Val Ala Lys Tyr 
145                 150                 155                 160 


Phe Ser Leu Pro Ser Val Val Phe Thr Arg Gly Ile Phe Cys His His 
                165                 170                 175     


Leu Glu Glu Gly Ala Gln Cys Pro Ala Pro Leu Ser Tyr Val Pro Asn 
            180                 185                 190         


Asp Leu Leu Gly Phe Ser Asp Ala Met Thr Phe Lys Glu Arg Val Trp 
        195                 200                 205             


Asn His Ile Val His Leu Glu Asp His Leu Phe Cys Gln Tyr Leu Phe 
    210                 215                 220                 


Arg Asn Ala Leu Glu Ile Ala Ser Glu Ile Leu Gln Thr Pro Val Thr 
225                 230                 235                 240 


Ala Tyr Asp Leu Tyr Ser His Thr Ser Ile Trp Leu Leu Arg Thr Asp 
                245                 250                 255     


Phe Val Leu Asp Tyr Pro Lys Pro Val Met Pro Asn Met Ile Phe Ile 
            260                 265                 270         


Gly Gly Ile Asn Cys His Gln Gly Lys Pro Leu Pro Met Glu Phe Glu 
        275                 280                 285             


Ala Tyr Ile Asn Ala Ser Gly Glu His Gly Ile Val Val Phe Ser Leu 
    290                 295                 300                 


Gly Ser Met Val Ser Glu Ile Pro Glu Lys Lys Ala Met Ala Ile Ala 
305                 310                 315                 320 


Asp Ala Leu Gly Lys Ile Pro Gln Thr Val Leu Trp Arg Tyr Thr Gly 
                325                 330                 335     


Thr Arg Pro Ser Asn Leu Ala Asn Asn Thr Ile Leu Val Lys Trp Leu 
            340                 345                 350         


Pro Gln Asn Asp Leu Leu Gly His Pro Met Thr Arg Ala Phe Ile Thr 
        355                 360                 365             


His Ala Gly Ser His Gly Val Tyr Glu Ser Ile Cys Asn Gly Val Pro 
    370                 375                 380                 


Met Val Met Met Pro Leu Phe Gly Asp Gln Met Asp Asn Ala Lys Arg 
385                 390                 395                 400 


Met Glu Thr Lys Gly Ala Gly Val Thr Leu Asn Val Leu Glu Met Thr 
                405                 410                 415     


Ser Glu Asp Leu Glu Asn Ala Leu Lys Ala Val Ile Asn Asp Lys Arg 
            420                 425                 430         


Lys Lys Gln Gln Ser Gly Arg Gln Met 
        435                 440     


<210>  189
<211>  2426
<212>  DNA
<213>  Homosapiens

<400>  189
ggttttgtgc tggtatttct cccacctact gtatcatagg agcttagatt cccagctgct     60

tgctctcagc tgcagttctc tgatggcttg cacagggtgg accagccccc ttcctctatg    120

tgtgtgtctg ctgctgacct gtggctttgc cgaggcaggg aagctactgg tagtgcccat    180

ggatgggagc cactggttca ccatgaggtc ggtggtggag aaactcattc tcagggggca    240

tgaggtggtt gtagtcatgc cagaggtgag ttggcaactg ggaagatcac tgaattgcac    300

agtgaagact tattcaactt catataccct ggaggatctg gaccgggagt tcaaggcttt    360

tgcccatgct caatggaaag cacaagtacg aagtatatat tctctattaa tgggttcata    420

caatgacatt tttgacttat ttttttcaaa ttgcaggagt ttgtttaaag acaaaaaatt    480

agtagaatac ttaaaggaga gttcttttga tgcagtgttt ctcgatcctt ttgataactg    540

tggcttaatt gttgccaaat atttctccct cccctccgtg gtcttcgcca ggggaatact    600

ttgccactat cttgaagaag gtgcacagtg ccctgctcct ctttcctatg tccccagaat    660

tctcttaggg ttctcagatg ccatgacttt caaggagaga gtacggaacc acatcatgca    720

cttggaggaa catttattat gccaccgttt tttcaaaaat gccctagaaa tagcctctga    780

aattctccaa acacctgtta cggagtatga tctctacagc cacacatcaa tttggttgtt    840

gcgaacggac tttgttttgg actatcccaa acccgtgatg cccaacatga tcttcattgg    900

tggtatcaac tgccatcagg gaaagccgtt gcctatggaa tttgaagcct acattaatgc    960

ttctggagaa catggaattg tggttttctc tttgggatca atggtctcag aaattccaga   1020

gaagaaagct atggcaattg ctgatgcttt gggcaaaatc cctcagacag tcctgtggcg   1080

gtacactgga acccgaccat cgaatcttgc gaacaacacg atacttgtta agtggctacc   1140

ccaaaacgat ctgcttggtc acccgatgac ccgtgccttt atcacccatg ctggttccca   1200

tggtgtttat gaaagcatat gcaatggcgt tcccatggtg atgatgccct tgtttggtga   1260

tcagatggac aatgcaaagc gcatggagac taagggagct ggagtgaccc tgaatgttct   1320

ggaaatgact tctgaagatt tagaaaatgc tctaaaagca gtcatcaatg acaaaagtta   1380

caaggagaac atcatgcgcc tctccagcct tcacaaggac cgcccggtgg agccgctgga   1440

cctggccgtg ttctgggtgg agtttgtgat gaggcacaag ggcgcgccac acctgcgccc   1500

cgcagcccac gacctcacct ggtaccagta ccattccttg gacgtgattg gtttcctctt   1560

ggccgtcgtg ctgacagtgg ccttcatcac ctttaaatgt tgtgcttatg gctaccggaa   1620

atgcttgggg aaaaaagggc gagttaagaa agcccacaaa tccaagaccc attgagaagt   1680

gggtgggaaa taaggtaaaa ttttgaacca ttccctagtc atttccaaac ttgaaaacag   1740

aatcagtgtt aaattcattt tattcttatt aaggaaatac tttgcataaa ttaatcagcc   1800

ccagagtgct ttaaaaaatt ctcttaaata aaaataatag actcgctagt cagtaaagat   1860

atttgaatat gtatcgtgcc ccctctggtg tctttgatca ggatgacatg tgccattttt   1920

cagaggacgt gcagacaggc tggcattcta gattactttt cttactctga aacatggcct   1980

gtttgggagt gcgggattca aaggtggtcc cacggctgcc cctactgcaa atggcagttt   2040

taatcttatc ttttggcttc tgcagatggt tgcaattgat ccttaaccaa taatggtcag   2100

tcctcatctc tgtcgtgctt cataggtgcc accttgtgtg tttaaagaag ggaagctttg   2160

tacctttaga gtgtaggtga aatgaatgaa tggcttggag tgcactgaga acagcatatg   2220

atttcttgct ttggggaaaa agaatgatgc tatgaaattg gtgggtggtg tatttgagaa   2280

gataatcatt gcttatgtca aatggagctg aatttgataa aaacccaaaa tacagctatg   2340

aagtgctggg caagtttact ttttttctga tgtttcctac aactaaaaat aaattaataa   2400

atttatataa attctattta agtgtt                                        2426


<210>  190
<211>  530
<212>  PRT
<213>  Homosapiens

<400>  190

Met Ala Cys Thr Gly Trp Thr Ser Pro Leu Pro Leu Cys Val Cys Leu 
1               5                   10                  15      


Leu Leu Thr Cys Gly Phe Ala Glu Ala Gly Lys Leu Leu Val Val Pro 
            20                  25                  30          


Met Asp Gly Ser His Trp Phe Thr Met Arg Ser Val Val Glu Lys Leu 
        35                  40                  45              


Ile Leu Arg Gly His Glu Val Val Val Val Met Pro Glu Val Ser Trp 
    50                  55                  60                  


Gln Leu Gly Arg Ser Leu Asn Cys Thr Val Lys Thr Tyr Ser Thr Ser 
65                  70                  75                  80  


Tyr Thr Leu Glu Asp Leu Asp Arg Glu Phe Lys Ala Phe Ala His Ala 
                85                  90                  95      


Gln Trp Lys Ala Gln Val Arg Ser Ile Tyr Ser Leu Leu Met Gly Ser 
            100                 105                 110         


Tyr Asn Asp Ile Phe Asp Leu Phe Phe Ser Asn Cys Arg Ser Leu Phe 
        115                 120                 125             


Lys Asp Lys Lys Leu Val Glu Tyr Leu Lys Glu Ser Ser Phe Asp Ala 
    130                 135                 140                 


Val Phe Leu Asp Pro Phe Asp Asn Cys Gly Leu Ile Val Ala Lys Tyr 
145                 150                 155                 160 


Phe Ser Leu Pro Ser Val Val Phe Ala Arg Gly Ile Leu Cys His Tyr 
                165                 170                 175     


Leu Glu Glu Gly Ala Gln Cys Pro Ala Pro Leu Ser Tyr Val Pro Arg 
            180                 185                 190         


Ile Leu Leu Gly Phe Ser Asp Ala Met Thr Phe Lys Glu Arg Val Arg 
        195                 200                 205             


Asn His Ile Met His Leu Glu Glu His Leu Leu Cys His Arg Phe Phe 
    210                 215                 220                 


Lys Asn Ala Leu Glu Ile Ala Ser Glu Ile Leu Gln Thr Pro Val Thr 
225                 230                 235                 240 


Glu Tyr Asp Leu Tyr Ser His Thr Ser Ile Trp Leu Leu Arg Thr Asp 
                245                 250                 255     


Phe Val Leu Asp Tyr Pro Lys Pro Val Met Pro Asn Met Ile Phe Ile 
            260                 265                 270         


Gly Gly Ile Asn Cys His Gln Gly Lys Pro Leu Pro Met Glu Phe Glu 
        275                 280                 285             


Ala Tyr Ile Asn Ala Ser Gly Glu His Gly Ile Val Val Phe Ser Leu 
    290                 295                 300                 


Gly Ser Met Val Ser Glu Ile Pro Glu Lys Lys Ala Met Ala Ile Ala 
305                 310                 315                 320 


Asp Ala Leu Gly Lys Ile Pro Gln Thr Val Leu Trp Arg Tyr Thr Gly 
                325                 330                 335     


Thr Arg Pro Ser Asn Leu Ala Asn Asn Thr Ile Leu Val Lys Trp Leu 
            340                 345                 350         


Pro Gln Asn Asp Leu Leu Gly His Pro Met Thr Arg Ala Phe Ile Thr 
        355                 360                 365             


His Ala Gly Ser His Gly Val Tyr Glu Ser Ile Cys Asn Gly Val Pro 
    370                 375                 380                 


Met Val Met Met Pro Leu Phe Gly Asp Gln Met Asp Asn Ala Lys Arg 
385                 390                 395                 400 


Met Glu Thr Lys Gly Ala Gly Val Thr Leu Asn Val Leu Glu Met Thr 
                405                 410                 415     


Ser Glu Asp Leu Glu Asn Ala Leu Lys Ala Val Ile Asn Asp Lys Ser 
            420                 425                 430         


Tyr Lys Glu Asn Ile Met Arg Leu Ser Ser Leu His Lys Asp Arg Pro 
        435                 440                 445             


Val Glu Pro Leu Asp Leu Ala Val Phe Trp Val Glu Phe Val Met Arg 
    450                 455                 460                 


His Lys Gly Ala Pro His Leu Arg Pro Ala Ala His Asp Leu Thr Trp 
465                 470                 475                 480 


Tyr Gln Tyr His Ser Leu Asp Val Ile Gly Phe Leu Leu Ala Val Val 
                485                 490                 495     


Leu Thr Val Ala Phe Ile Thr Phe Lys Cys Cys Ala Tyr Gly Tyr Arg 
            500                 505                 510         


Lys Cys Leu Gly Lys Lys Gly Arg Val Lys Lys Ala His Lys Ser Lys 
        515                 520                 525             


Thr His 
    530 


<210>  191
<211>  2344
<212>  DNA
<213>  Homosapiens

<400>  191
atggctcgtg cagggtggac tggcctcctt cccctatatg tgtgtctact gctgacctgt     60

ggctttgcca aggcagggaa gctgctggta gtgcccatgg atgggagcca ctggttcacc    120

atgcagtcgg tggtggagaa actcatcctc agggggcatg aggtggtcgt agtcatgcca    180

gaggtgagtt ggcaactggg aagatcactg aattgcacag tgaagactta ctcaacctca    240

tacactctgg aggatcagga ccgggagttc atggtttttg ccgatgctcg ctggacggca    300

ccattgcgaa gtgcattttc tctattaaca agttcatcca atggtatttt tgacttattt    360

ttttcaaatt gcaggagttt gtttaatgac cgaaaattag tagaatactt aaaggagagt    420

tgttttgatg cagtgtttct cgatcctttt gatgcctgtg gcttaattgt tgccaaatat    480

ttctccctcc cctctgtggt cttcgccagg ggaatatttt gccactatct tgaagaaggt    540

gcacagtgcc ctgctcctct ttcctatgtc cccagacttc tcttagggtt ctcagacgcc    600

atgactttca aggagagagt atggaaccac atcatgcact tggaggaaca tttattttgc    660

ccctattttt tcaaaaatgt cttagaaata gcctctgaaa ttctccaaac ccctgtcacg    720

gcatatgatc tctacagcca cacatcaatt tggttgttgc gaactgactt tgttttggag    780

tatcccaaac ccgtgatgcc caatatgatc ttcattggtg gtatcaactg tcatcaggga    840

aagccagtgc ctatggaatt tgaagcctac attaatgctt ctggagaaca tggaattgtg    900

gttttctctt tgggatcaat ggtctcagaa attccagaga agaaagctat ggcaattgct    960

gatgctttgg gcaaaatccc tcagacagtc ctgtggcggt acactggaac ccgaccatcg   1020

aatcttgcga acaacacgat acttgttaag tggctacccc aaaacgatct gcttggtcac   1080

ccgatgaccc gtgcctttat cacccatgct ggttcccatg gtgtttatga aagcatatgc   1140

aatggcgttc ccatggtgat gatgcccttg tttggtgatc agatggacaa tgcaaagcgc   1200

atggagacta agggagctgg agtgaccctg aatgttctgg aaatgacttc tgaagattta   1260

gaaaatgctc taaaagcagt catcaatgac aaaagttaca aggagaacat catgcgcctc   1320

tccagccttc acaaggaccg cccggtggag ccgctggacc tggccgtgtt ctgggtggag   1380

tttgtgatga ggcacaaggg cgcgccacac ctgcgccccg cagcccacga cctcacctgg   1440

taccagtacc attccttgga cgtgattggt ttcctcttgg ccgtcgtgct gacagtggcc   1500

ttcatcacct ttaaatgttg tgcttatggc taccggaaat gcttggggaa aaaagggcga   1560

gttaagaaag cccacaaatc caagacccat tgagaagtgg gtgggaaata aggtaaaatt   1620

ttgaaccatt ccctagtcat ttccaaactt gaaaacagaa tcagtgttaa attcatttta   1680

ttcttattaa ggaaatactt tgcataaatt aatcagcccc agagtgcttt aaaaaattct   1740

cttaaataaa aataatagac tcgctagtca gtaaagatat ttgaatatgt atcgtgcccc   1800

ctctggtgtc tttgatcagg atgacatgtg ccatttttca gaggacgtgc agacaggctg   1860

gcattctaga ttacttttct tactctgaaa catggcctgt ttgggagtgc gggattcaaa   1920

ggtggtccca cggctgcccc tactgcaaat ggcagtttta atcttatctt ttggcttctg   1980

cagatggttg caattgatcc ttaaccaata atggtcagtc ctcatctctg tcgtgcttca   2040

taggtgccac cttgtgtgtt taaagaaggg aagctttgta cctttagagt gtaggtgaaa   2100

tgaatgaatg gcttggagtg cactgagaac agcatatgat ttcttgcttt ggggaaaaag   2160

aatgatgcta tgaaattggt gggtggtgta tttgagaaga taatcattgc ttatgtcaaa   2220

tggagctgaa tttgataaaa acccaaaata cagctatgaa gtgctgggca agtttacttt   2280

ttttctgatg tttcctacaa ctaaaaataa attaataaat ttatataaat tctatttaag   2340

tgtt                                                                2344


<210>  192
<211>  530
<212>  PRT
<213>  Homosapiens

<400>  192

Met Ala Arg Ala Gly Trp Thr Gly Leu Leu Pro Leu Tyr Val Cys Leu 
1               5                   10                  15      


Leu Leu Thr Cys Gly Phe Ala Lys Ala Gly Lys Leu Leu Val Val Pro 
            20                  25                  30          


Met Asp Gly Ser His Trp Phe Thr Met Gln Ser Val Val Glu Lys Leu 
        35                  40                  45              


Ile Leu Arg Gly His Glu Val Val Val Val Met Pro Glu Val Ser Trp 
    50                  55                  60                  


Gln Leu Gly Arg Ser Leu Asn Cys Thr Val Lys Thr Tyr Ser Thr Ser 
65                  70                  75                  80  


Tyr Thr Leu Glu Asp Gln Asp Arg Glu Phe Met Val Phe Ala Asp Ala 
                85                  90                  95      


Arg Trp Thr Ala Pro Leu Arg Ser Ala Phe Ser Leu Leu Thr Ser Ser 
            100                 105                 110         


Ser Asn Gly Ile Phe Asp Leu Phe Phe Ser Asn Cys Arg Ser Leu Phe 
        115                 120                 125             


Asn Asp Arg Lys Leu Val Glu Tyr Leu Lys Glu Ser Cys Phe Asp Ala 
    130                 135                 140                 


Val Phe Leu Asp Pro Phe Asp Ala Cys Gly Leu Ile Val Ala Lys Tyr 
145                 150                 155                 160 


Phe Ser Leu Pro Ser Val Val Phe Ala Arg Gly Ile Phe Cys His Tyr 
                165                 170                 175     


Leu Glu Glu Gly Ala Gln Cys Pro Ala Pro Leu Ser Tyr Val Pro Arg 
            180                 185                 190         


Leu Leu Leu Gly Phe Ser Asp Ala Met Thr Phe Lys Glu Arg Val Trp 
        195                 200                 205             


Asn His Ile Met His Leu Glu Glu His Leu Phe Cys Pro Tyr Phe Phe 
    210                 215                 220                 


Lys Asn Val Leu Glu Ile Ala Ser Glu Ile Leu Gln Thr Pro Val Thr 
225                 230                 235                 240 


Ala Tyr Asp Leu Tyr Ser His Thr Ser Ile Trp Leu Leu Arg Thr Asp 
                245                 250                 255     


Phe Val Leu Glu Tyr Pro Lys Pro Val Met Pro Asn Met Ile Phe Ile 
            260                 265                 270         


Gly Gly Ile Asn Cys His Gln Gly Lys Pro Val Pro Met Glu Phe Glu 
        275                 280                 285             


Ala Tyr Ile Asn Ala Ser Gly Glu His Gly Ile Val Val Phe Ser Leu 
    290                 295                 300                 


Gly Ser Met Val Ser Glu Ile Pro Glu Lys Lys Ala Met Ala Ile Ala 
305                 310                 315                 320 


Asp Ala Leu Gly Lys Ile Pro Gln Thr Val Leu Trp Arg Tyr Thr Gly 
                325                 330                 335     


Thr Arg Pro Ser Asn Leu Ala Asn Asn Thr Ile Leu Val Lys Trp Leu 
            340                 345                 350         


Pro Gln Asn Asp Leu Leu Gly His Pro Met Thr Arg Ala Phe Ile Thr 
        355                 360                 365             


His Ala Gly Ser His Gly Val Tyr Glu Ser Ile Cys Asn Gly Val Pro 
    370                 375                 380                 


Met Val Met Met Pro Leu Phe Gly Asp Gln Met Asp Asn Ala Lys Arg 
385                 390                 395                 400 


Met Glu Thr Lys Gly Ala Gly Val Thr Leu Asn Val Leu Glu Met Thr 
                405                 410                 415     


Ser Glu Asp Leu Glu Asn Ala Leu Lys Ala Val Ile Asn Asp Lys Ser 
            420                 425                 430         


Tyr Lys Glu Asn Ile Met Arg Leu Ser Ser Leu His Lys Asp Arg Pro 
        435                 440                 445             


Val Glu Pro Leu Asp Leu Ala Val Phe Trp Val Glu Phe Val Met Arg 
    450                 455                 460                 


His Lys Gly Ala Pro His Leu Arg Pro Ala Ala His Asp Leu Thr Trp 
465                 470                 475                 480 


Tyr Gln Tyr His Ser Leu Asp Val Ile Gly Phe Leu Leu Ala Val Val 
                485                 490                 495     


Leu Thr Val Ala Phe Ile Thr Phe Lys Cys Cys Ala Tyr Gly Tyr Arg 
            500                 505                 510         


Lys Cys Leu Gly Lys Lys Gly Arg Val Lys Lys Ala His Lys Ser Lys 
        515                 520                 525             


Thr His 
    530 


<210>  193
<211>  2256
<212>  DNA
<213>  Homosapiens

<400>  193
cagtgtttct cgatcctttt gatgcctgtg gcttaattgt tgccaaatat ttctccctcc     60

cctctgtggt cttcgccagg ggaatatttt gccactatct tgaagaaggt gcacagtgcc    120

ctgctcctct ttcctatgtc cccagacttc tcttagggtt ctcagacgcc atgactttca    180

aggagagagt atggaaccac atcatgcact tggaggaaca tttattttgc ccctattttt    240

tcaaaaatgt cttagaaata gcctctgaaa ttctccaaac ccctgtcacg gcatatgatc    300

tctacagcca cacatcaatt tggttgttgc gaactgactt tgttttggag tatcccaaac    360

ccgtgatgcc caatatgatc ttcattggtg gtatcaactg tcatcaggga aagccagtgc    420

ctatggtaag atctacttct ttcaccccac tggaatatgt cccaagcctg agtcattcag    480

cctgcagcaa tccctgagaa aaaaaaaaaa tcggcctttg cctggacact caagtgatac    540

ctgaggacac cttgactcct acagcaccaa ccagggcagg cctgggtctc cagcggagct    600

actctttagg gatcgtcatt atgacgaaca gacatgccag attcctctgg ctagtgtcca    660

gtgcagacat acacacacac acacatacac acacacacac acacacacac cattcttagt    720

acagtcaaag ctcacaggag aaagaaaaat gttttctaat accttcttaa tttgcaagaa    780

ggtgttagga attcaaggga tggtatgcat agtgatgtta gtttcatttc ttcagctcct    840

tcctccaact catgttctgt agggacttct gggactaaga acaggaccca catatgagca    900

acaggatttt cagagcaagg ctgtggttgg aagggctcag accaacgtcc acagcagagt    960

ggaggtctag tataaagaat gtgaagtttg tagcatctct tgatcccgct attcctacat   1020

gcttgcttaa gccattcttc ctctagatga actgttcttt gaaggaaacc tgcctaatgt   1080

ctgcctgctc aagaaggtgg acctgagctc tgttcccttt gcaaccttcc tggagtctta   1140

ttgctatcta gatgaactca aagcaagatg ctgccgcccc catgactttg atcattgtaa   1200

gctgccaatc ctcttgggag gctgctccca gcttggactg agctgagtct tcgcatgcct   1260

tgaacaatga atttgcatcc tggttatgtt ccccatgggg gccagccctg tccttggagt   1320

ggcccctcta atcatgttgc tcaggcttct tctcccttcc tgggccccag aacacctccg   1380

gtgccaaact tgtgggtggg aacaggaact cgcgtgccag ccaggtgtgc atgactagct   1440

ctgggcaagt ctgttctagt aattcaaggt accacctctc actgggacag cctagtttct   1500

acacaggtct tgctctggga ccgccctcag cagtgtggtt agcaggcagg gccagtgtga   1560

ccctcccttt ctgggcctca gttgagaaac ctgaagctca ggagaggagt cactcccctg   1620

gcagatgggt ggctgggcca gaagcagata ccaggctttc tgactcctgc tctaggattc   1680

tcaccacgta ctggctagac ttatacttct caaatcttaa tttcctaaag gcaagtaaca   1740

gtttgaatgt tgttatattg tgatgtataa taagaaatat atgtttgtct ttgtttcctg   1800

gacacagctc ctgaaaccat aagtggtggg agcgataaac gtgaacaaag aatcttttgt   1860

tattcaaaac agatcccttt cgatcacacc taagtttatg taaaggagat gtaaagtctc   1920

taaggatgag ggctagttgc cagggaacaa aacccttgcg attagaggga agaaaggaga   1980

gagagattga agattgattt gatcaccgat gggcaacaat ctaatcaatc atgcctacta   2040

tgtatggaag cctacataaa aactcagaag ggcagggttc agagagcttt caggttgctg   2100

aaggtgtgga gggtggggca cccagagatg gcagatgggg ctccatggcc atacccccat   2160

atcttgttct ttgtactttt tcctctggct attcatccgt attgtttgca atatcctttg   2220

taataaacca aacctagtaa ataaactgtt ttcttc                             2256


<210>  194
<211>  108
<212>  PRT
<213>  Homosapiens

<400>  194

Met Thr Phe Lys Glu Arg Val Trp Asn His Ile Met His Leu Glu Glu 
1               5                   10                  15      


His Leu Phe Cys Pro Tyr Phe Phe Lys Asn Val Leu Glu Ile Ala Ser 
            20                  25                  30          


Glu Ile Leu Gln Thr Pro Val Thr Ala Tyr Asp Leu Tyr Ser His Thr 
        35                  40                  45              


Ser Ile Trp Leu Leu Arg Thr Asp Phe Val Leu Glu Tyr Pro Lys Pro 
    50                  55                  60                  


Val Met Pro Asn Met Ile Phe Ile Gly Gly Ile Asn Cys His Gln Gly 
65                  70                  75                  80  


Lys Pro Val Pro Met Val Arg Ser Thr Ser Phe Thr Pro Leu Glu Tyr 
                85                  90                  95      


Val Pro Ser Leu Ser His Ser Ala Cys Ser Asn Pro 
            100                 105             


<210>  195
<211>  1463
<212>  DNA
<213>  Homosapiens

<400>  195
gggaccgccc tcagcagtgt ggttagcagg cagggccagt gtgaccctcc ctttctgggc     60

ctcagttgag aaacctgaag ctcaggagag gagtcactcc cctggcagat gggtggctgg    120

gccagaagca gataccaggc tttctgactc ctgctctagg attctcacca cgtactggct    180

agacttatac ttctcaaatc ttaatttcct aaaggccggt catgcccaac atggtcttca    240

ttggaggtat caactgtaag aagaggaaag acttgtctca ggaatttgaa gcctacatta    300

atgcttctgg agaacatgga attgtggttt tctctttggg atcaatggtc tcagaaattc    360

cagagaagaa agctatggca attgctgatg ctttgggcaa aatccctcag acagtcctgt    420

ggcggtacac tggaacccga ccatcgaatc ttgcgaacaa cacgatactt gttaagtggc    480

taccccaaaa cgatctgctt ggtcacccga tgacccgtgc ctttatcacc catgctggtt    540

cccatggtgt ttatgaaagc atatgcaatg gcgttcccat ggtgatgatg cccttgtttg    600

gtgatcagat ggacaatgca aagcgcatgg agactaaggg agctggagtg accctgaatg    660

ttctggaaat gacttctgaa gatttagaaa atgctctaaa agcagtcatc aatgacaaaa    720

gaaagaagca gcagtcagga agacagatgt gaagagctgg agcatgttca gatgagagga    780

gacggaacac ggggacacac cagcttgagc aagggacaac aggggaggac tgatgactga    840

cttcccacct ttgaggtgct aatgtgtgtg tggtggcact ggataaaaga tcaatgttgg    900

ctaggcacca tggcacacgc ctgtagtccc agccactctg gaggctaagg cgggaggatt    960

gcttgagccc agaagttgga ggctgctatg agccgtgatc atgccactgc actccagcaa   1020

cctgggcaac agagtgagac cctgtctcaa aaaaaaaaaa aaaaatgaaa agtccacata   1080

acctgagcat catgtgccca gagcgttggg tggtgtggtc ccattccttc cttccagcgg   1140

cttcttctgg ccacctcaat gtcaggatgt cctgctcaca tatcaatacc attaaaacct   1200

gacttctttc cctgcactgt tgaagctcct tcttgaggct cacattatgg atataatttt   1260

gattctttct tcagtggtat agataactac ttgtaaccta agaacaactt ggtgaaagtc   1320

ctctaataca ttatttttta aaaaaacaca aatcaatgag ctcaacttat taactaactt   1380

tcatctattc atttttgagc catccctgtc tgattgtgaa tctccatgat tccaacactc   1440

tgagctgggg atagtgccta cac                                           1463


<210>  196
<211>  176
<212>  PRT
<213>  Homosapiens

<400>  196

Met Pro Asn Met Val Phe Ile Gly Gly Ile Asn Cys Lys Lys Arg Lys 
1               5                   10                  15      


Asp Leu Ser Gln Glu Phe Glu Ala Tyr Ile Asn Ala Ser Gly Glu His 
            20                  25                  30          


Gly Ile Val Val Phe Ser Leu Gly Ser Met Val Ser Glu Ile Pro Glu 
        35                  40                  45              


Lys Lys Ala Met Ala Ile Ala Asp Ala Leu Gly Lys Ile Pro Gln Thr 
    50                  55                  60                  


Val Leu Trp Arg Tyr Thr Gly Thr Arg Pro Ser Asn Leu Ala Asn Asn 
65                  70                  75                  80  


Thr Ile Leu Val Lys Trp Leu Pro Gln Asn Asp Leu Leu Gly His Pro 
                85                  90                  95      


Met Thr Arg Ala Phe Ile Thr His Ala Gly Ser His Gly Val Tyr Glu 
            100                 105                 110         


Ser Ile Cys Asn Gly Val Pro Met Val Met Met Pro Leu Phe Gly Asp 
        115                 120                 125             


Gln Met Asp Asn Ala Lys Arg Met Glu Thr Lys Gly Ala Gly Val Thr 
    130                 135                 140                 


Leu Asn Val Leu Glu Met Thr Ser Glu Asp Leu Glu Asn Ala Leu Lys 
145                 150                 155                 160 


Ala Val Ile Asn Asp Lys Arg Lys Lys Gln Gln Ser Gly Arg Gln Met 
                165                 170                 175     


<210>  197
<211>  1770
<212>  DNA
<213>  Homosapiens

<400>  197
gggaccgccc tcagcagtgt ggttagcagg cagggccagt gtgaccctcc ctttctgggc     60

ctcagttgag aaacctgaag ctcaggagag gagtcactcc cctggcagat gggtggctgg    120

gccagaagca gataccaggc tttctgactc ctgctctagg attctcacca cgtactggct    180

agacttatac ttctcaaatc ttaatttcct aaaggccggt catgcccaac atggtcttca    240

ttggaggtat caactgtaag aagaggaaag acttgtctca ggaatttgaa gcctacatta    300

atgcttctgg agaacatgga attgtggttt tctctttggg atcaatggtc tcagaaattc    360

cagagaagaa agctatggca attgctgatg ctttgggcaa aatccctcag acagtcctgt    420

ggcggtacac tggaacccga ccatcgaatc ttgcgaacaa cacgatactt gttaagtggc    480

taccccaaaa cgatctgctt ggtcacccga tgacccgtgc ctttatcacc catgctggtt    540

cccatggtgt ttatgaaagc atatgcaatg gcgttcccat ggtgatgatg cccttgtttg    600

gtgatcagat ggacaatgca aagcgcatgg agactaaggg agctggagtg accctgaatg    660

ttctggaaat gacttctgaa gatttagaaa atgctctaaa agcagtcatc aatgacaaaa    720

gttacaagga gaacatcatg cgcctctcca gccttcacaa ggaccgcccg gtggagccgc    780

tggacctggc cgtgttctgg gtggagtttg tgatgaggca caagggcgcg ccacacctgc    840

gccccgcagc ccacgacctc acctggtacc agtaccattc cttggacgtg attggtttcc    900

tcttggccgt cgtgctgaca gtggccttca tcacctttaa atgttgtgct tatggctacc    960

ggaaatgctt ggggaaaaaa gggcgagtta agaaagccca caaatccaag acccattgag   1020

aagtgggtgg gaaataaggt aaaattttga accattccct agtcatttcc aaacttgaaa   1080

acagaatcag tgttaaattc attttattct tattaaggaa atactttgca taaattaatc   1140

agccccagag tgctttaaaa aattctctta aataaaaata atagactcgc tagtcagtaa   1200

agatatttga atatgtatcg tgccccctct ggtgtctttg atcaggatga catgtgccat   1260

ttttcagagg acgtgcagac aggctggcat tctagattac ttttcttact ctgaaacatg   1320

gcctgtttgg gagtgcggga ttcaaaggtg gtcccacggc tgcccctact gcaaatggca   1380

gttttaatct tatcttttgg cttctgcaga tggttgcaat tgatccttaa ccaataatgg   1440

tcagtcctca tctctgtcgt gcttcatagg tgccaccttg tgtgtttaaa gaagggaagc   1500

tttgtacctt tagagtgtag gtgaaatgaa tgaatggctt ggagtgcact gagaacagca   1560

tatgatttct tgctttgggg aaaaagaatg atgctatgaa attggtgggt ggtgtatttg   1620

agaagataat cattgcttat gtcaaatgga gctgaatttg ataaaaaccc aaaatacagc   1680

tatgaagtgc tgggcaagtt tacttttttt ctgatgtttc ctacaactaa aaataaatta   1740

ataaatttat ataaattcta tttaagtgtt                                    1770


<210>  198
<211>  265
<212>  PRT
<213>  Homosapiens

<400>  198

Met Pro Asn Met Val Phe Ile Gly Gly Ile Asn Cys Lys Lys Arg Lys 
1               5                   10                  15      


Asp Leu Ser Gln Glu Phe Glu Ala Tyr Ile Asn Ala Ser Gly Glu His 
            20                  25                  30          


Gly Ile Val Val Phe Ser Leu Gly Ser Met Val Ser Glu Ile Pro Glu 
        35                  40                  45              


Lys Lys Ala Met Ala Ile Ala Asp Ala Leu Gly Lys Ile Pro Gln Thr 
    50                  55                  60                  


Val Leu Trp Arg Tyr Thr Gly Thr Arg Pro Ser Asn Leu Ala Asn Asn 
65                  70                  75                  80  


Thr Ile Leu Val Lys Trp Leu Pro Gln Asn Asp Leu Leu Gly His Pro 
                85                  90                  95      


Met Thr Arg Ala Phe Ile Thr His Ala Gly Ser His Gly Val Tyr Glu 
            100                 105                 110         


Ser Ile Cys Asn Gly Val Pro Met Val Met Met Pro Leu Phe Gly Asp 
        115                 120                 125             


Gln Met Asp Asn Ala Lys Arg Met Glu Thr Lys Gly Ala Gly Val Thr 
    130                 135                 140                 


Leu Asn Val Leu Glu Met Thr Ser Glu Asp Leu Glu Asn Ala Leu Lys 
145                 150                 155                 160 


Ala Val Ile Asn Asp Lys Ser Tyr Lys Glu Asn Ile Met Arg Leu Ser 
                165                 170                 175     


Ser Leu His Lys Asp Arg Pro Val Glu Pro Leu Asp Leu Ala Val Phe 
            180                 185                 190         


Trp Val Glu Phe Val Met Arg His Lys Gly Ala Pro His Leu Arg Pro 
        195                 200                 205             


Ala Ala His Asp Leu Thr Trp Tyr Gln Tyr His Ser Leu Asp Val Ile 
    210                 215                 220                 


Gly Phe Leu Leu Ala Val Val Leu Thr Val Ala Phe Ile Thr Phe Lys 
225                 230                 235                 240 


Cys Cys Ala Tyr Gly Tyr Arg Lys Cys Leu Gly Lys Lys Gly Arg Val 
                245                 250                 255     


Lys Lys Ala His Lys Ser Lys Thr His 
            260                 265 


<210>  199
<211>  1871
<212>  DNA
<213>  Homosapiens

<400>  199
actcccctgg cagatgggtg gctgggccag aagcagatac caggctttct gactcctgct     60

ctaggattct caccacgtac tggctagact tatacttctc aaatcttaat ttcctaaagg    120

ccggtcatgc ccaacatggt cttcattgga ggtatcaact gtaagaagag gaaagacttg    180

tctcagtgga agtcgacatg gacttgaagc tgcctgtccc atcactaccg taggacatgc    240

agaaggaaga aaggccccca cttcccaggg agccaaagga acgaaatcct gtatcaaaag    300

aagaaaaacc accctcaaaa gctggaaatt cactgaaggc agagaaaagg ggtgcagacc    360

ctctgcttct gcttcccagg gagttcctct gaccccccaa aatattctcc agcgggtttc    420

ccaagaggtc aaaggagaat gggtcccggc cgccaaagaa ctccctgaag acctcggcgg    480

ggtcacggaa gctgaagacc tactcgaagg ggtccttgaa gggcctgccg cctgcgcagc    540

cgccctccgc cctcgcctcg ccatagcggt catagatatc gcgtttctac gcgtccgaca    600

acacctcgta ggcctcagcc acctgcttga atcttctcac cgcttcctcc ctgtcctcgg    660

ggtttttgtc ggggtgccac ttgagcgcca gcttgcggta cgccttcttg ataccctcgg    720

acgaggccta ccggggtact cccagcacct cgtagtagtc cactatgctg gactgccaaa    780

gagcctgcgg ggcactggca cagcgagcgg caaggctgcc agcacccgcg cacaggtcag    840

aggcttggcg acctgggccg cctggagggc cgccccttat gacgcagcca catctcattg    900

gccgaggcct gtgagcgcct cgcatcccaa gatgcagtgc tcctgggact ggccctgctc    960

tctgtgaggc tctgtgaggc cctgtgatgc tccaagacca ggccccgccc actccggcct   1020

ccaaccagcc atggtctcca aaaaggatgg gaaaaagagg ttggggaaaa gagagggcct   1080

tgactttggc tgcctgaaga actgtttttc ttaaagtagg ctttatatca gtctttttcc   1140

tcggccacag gagggaagag ggtggtggga gtgagtttag tctgaccggg gctgaagaca   1200

tcctgttgtt taggactgcg gttctccaac gttccagccc cggtgcccat ttgcttttgt   1260

tcatctggat tatgcctatc atatgtactg cattagagat taaaacagaa ttaaaaagac   1320

atattcattg ggcaatttaa gaagaataaa cccatgacac actaacaaac ctttttatgt   1380

aacttttttt gagacaaaat gtagtgagaa gagtggcatc gttttacagt ttttgcatct   1440

ctctctttag tacttggctc tatagagagg tggattctca tgtcagcttc tgcattctat   1500

ctattgtgat attacacatc ccccatgtag cttctggaaa actccactgt acacttgtgg   1560

gagaatgaca atgagaaaat caagtaacat tattacggaa atagttttga ctttgtaaaa   1620

ttctcctgaa aaattactgg ggatccctag gatttcctgg ctcatacttt gagaatcgct   1680

agtctagcag agtagtccct ggtattctga agggattagt ttaggacaac cctccttccc   1740

cataccaaaa tctagatgct caagctcctt ttataaaatg acacagtatt tgtatataac   1800

ctacccatat cctcctttaa acctctagtc atctcttgat tacttttacc taataaatgt   1860

aaatgctatg t                                                        1871


<210>  200
<211>  51
<212>  PRT
<213>  Homosapiens

<400>  200

Met Gln Lys Glu Glu Arg Pro Pro Leu Pro Arg Glu Pro Lys Glu Arg 
1               5                   10                  15      


Asn Pro Val Ser Lys Glu Glu Lys Pro Pro Ser Lys Ala Gly Asn Ser 
            20                  25                  30          


Leu Lys Ala Glu Lys Arg Gly Ala Asp Pro Leu Leu Leu Leu Pro Arg 
        35                  40                  45              


Glu Phe Leu 
    50      


<210>  201
<211>  1226
<212>  DNA
<213>  Homosapiens

<400>  201
actggaacct tgaactcctg ggctcaaata atcctcccac ctcagccttc cgagtagtta     60

ggtctacagg cacacgctac catgtccagc taggttttta ctttctgtag tgaaggaatc    120

tcactatgct gcctaggctg gtctcaaact cctgggctca agctatcctc ctgcttcggc    180

cccgcaaagt gctgggatta taagcatgag ccaccacgct cagccagttg catcaattct    240

attaaatgca gaagttgata cctccaatga agaccatgtt gggcatgacc ggcctaggat    300

attcaagcac aaagtcatat cttaacagcc aaacagagac cttctgatat aaggtgatta    360

tatccacatc tctcttgagg acagctgatg cgagttcttc atactttgaa aacagacaat    420

aaaatagata gggctccaac aaattaacaa ggaagttggc cactcgttgg gaaaaagtca    480

tgtggtctga aaactttgtg tagcacctgg gaatgtagga cacagggtct gggcttctgc    540

tgaatgtatg ctccagggaa cacggaaaac ccctgaagag gtacacagat ggtaggccca    600

aatactcagc caggatcacc ccacagggta aggctgggtc tgtgaaaaga gcatcaaact    660

tgctctcctt aaagaagttc agggtgtccc tgtcctgcag gaggctctgg cagttgatga    720

agtacaggcc aataacaatc atgttattcc tgtactctgt ctgaggagca gttaggaatg    780

atcgctcagc aaagtgattg tttccaaatg attggtaacg gttcttcagc tcttcttggt    840

catacggcac tggatagatt tttcttgtgt agtatttgga ttctttcaaa agcaaattaa    900

cttcaggcac caccactaca atctcatgac cccggtcact gagaacctca actatatcct    960

tcatactaag ccagtggctt ccgtcctgag ggaccaccag cagcttgtca cctacaacca   1020

tgccccaaag tgctaagaag aaaacccctg cagaaattct ctgaaatgag cgaaggaggc   1080

aggccatcct ggaaagagtt aaagtaacaa cggtaataaa gagttttcac tctccaaatc   1140

acagggctcc taggtatttt ccctaaacta accactgctt ttcacaggtc ctgtctacct   1200

ctcccttgct ctgaatttta cccttt                                        1226


<210>  202
<211>  39
<212>  PRT
<213>  Homosapiens

<400>  202

Met Ser His His Ala Gln Pro Val Ala Ser Ile Leu Leu Asn Ala Glu 
1               5                   10                  15      


Val Asp Thr Ser Asn Glu Asp His Val Gly His Asp Arg Pro Arg Ile 
            20                  25                  30          


Phe Lys His Lys Val Ile Ser 
        35                  


<210>  203
<211>  2489
<212>  DNA
<213>  Homosapiens

<400>  203
aaagggtaaa attcagagca agggagaggt agacaggacc tgtgaaaagc agtggttagt     60

ttagggaaaa tacctaggag ccctgtgatt tggagagtga aaactcttta ttaccgttgt    120

tactttaact ctttccagga tggcctgcct ccttcgctca tttcagagaa tttctgcagg    180

ggttttcttc ttagcacttt ggggcatggt tgtaggtgac aagctgctgg tggtccctca    240

ggacggaagc cactggctta gtatgaagga tatagttgag gttctcagtg accggggtca    300

tgagattgta gtggtggtgc ctgaagttaa tttgcttttg aaagaatcca aatactacac    360

aagaaaaatc tatccagtgc cgtatgacca agaagagctg aagaaccgtt accaatcatt    420

tggaaacaat cactttgctg agcgatcatt cctaactgct cctcagacag agtacaggaa    480

taacatgatt gttattggcc tgtacttcat caactgccag agcctcctgc aggacaggga    540

caccctgaac ttctttaagg agagcaagtt tgatgctctt ttcacagacc cagccttacc    600

ctgtggggtg atcctggctg agtatttggg cctaccatct gtgtacctct tcaggggttt    660

tccgtgttcc ctggagcata cattcagcag aagcccagac cctgtgtcct acattcccag    720

gtgctacaca aagttttcag accacatgac tttttcccaa cgagtggcca acttccttgt    780

taatttgttg gagccctatc tattttattg tctgttttca aagtatgaag aactcgcatc    840

agctgtcctc aagagagatg tggatataat caccttatat cagaaggtct ctgtttggct    900

gttaagatat gactttgtgc ttgaatatcc taggccggtc atgcccaaca tggtcttcat    960

tggaggtatc aactgtaaga agaggaaaga cttgtctcag gaatttgaag cctacattaa   1020

tgcttctgga gaacatggaa ttgtggtttt ctctttggga tcaatggtct cagaaattcc   1080

agagaagaaa gctatggcaa ttgctgatgc tttgggcaaa atccctcaga cagtcctgtg   1140

gcggtacact ggaacccgac catcgaatct tgcgaacaac acgatacttg ttaagtggct   1200

accccaaaac gatctgcttg gtcacccgat gacccgtgcc tttatcaccc atgctggttc   1260

ccatggtgtt tatgaaagca tatgcaatgg cgttcccatg gtgatgatgc ccttgtttgg   1320

tgatcagatg gacaatgcaa agcgcatgga gactaaggga gctggagtga ccctgaatgt   1380

tctggaaatg acttctgaag atttagaaaa tgctctaaaa gcagtcatca atgacaaaag   1440

ttacaaggag aacatcatgc gcctctccag ccttcacaag gaccgcccgg tggagccgct   1500

ggacctggcc gtgttctggg tggagtttgt gatgaggcac aagggcgcgc cacacctgcg   1560

ccccgcagcc cacgacctca cctggtacca gtaccattcc ttggacgtga ttggtttcct   1620

cttggccgtc gtgctgacag tggccttcat cacctttaaa tgttgtgctt atggctaccg   1680

gaaatgcttg gggaaaaaag ggcgagttaa gaaagcccac aaatccaaga cccattgaga   1740

agtgggtggg aaataaggta aaattttgaa ccattcccta gtcatttcca aacttgaaaa   1800

cagaatcagt gttaaattca ttttattctt attaaggaaa tactttgcat aaattaatca   1860

gccccagagt gctttaaaaa attctcttaa ataaaaataa tagactcgct agtcagtaaa   1920

gatatttgaa tatgtatcgt gccccctctg gtgtctttga tcaggatgac atgtgccatt   1980

tttcagagga cgtgcagaca ggctggcatt ctagattact tttcttactc tgaaacatgg   2040

cctgtttggg agtgcgggat tcaaaggtgg tcccacggct gcccctactg caaatggcag   2100

ttttaatctt atcttttggc ttctgcagat ggttgcaatt gatccttaac caataatggt   2160

cagtcctcat ctctgtcgtg cttcataggt gccaccttgt gtgtttaaag aagggaagct   2220

ttgtaccttt agagtgtagg tgaaatgaat gaatggcttg gagtgcactg agaacagcat   2280

atgatttctt gctttgggga aaaagaatga tgctatgaaa ttggtgggtg gtgtatttga   2340

gaagataatc attgcttatg tcaaatggag ctgaatttga taaaaaccca aaatacagct   2400

atgaagtgct gggcaagttt actttttttc tgatgtttcc tacaactaaa aataaattaa   2460

taaatttata taaattctat ttaagtgtt                                     2489


<210>  204
<211>  532
<212>  PRT
<213>  Homosapiens

<400>  204

Met Ala Cys Leu Leu Arg Ser Phe Gln Arg Ile Ser Ala Gly Val Phe 
1               5                   10                  15      


Phe Leu Ala Leu Trp Gly Met Val Val Gly Asp Lys Leu Leu Val Val 
            20                  25                  30          


Pro Gln Asp Gly Ser His Trp Leu Ser Met Lys Asp Ile Val Glu Val 
        35                  40                  45              


Leu Ser Asp Arg Gly His Glu Ile Val Val Val Val Pro Glu Val Asn 
    50                  55                  60                  


Leu Leu Leu Lys Glu Ser Lys Tyr Tyr Thr Arg Lys Ile Tyr Pro Val 
65                  70                  75                  80  


Pro Tyr Asp Gln Glu Glu Leu Lys Asn Arg Tyr Gln Ser Phe Gly Asn 
                85                  90                  95      


Asn His Phe Ala Glu Arg Ser Phe Leu Thr Ala Pro Gln Thr Glu Tyr 
            100                 105                 110         


Arg Asn Asn Met Ile Val Ile Gly Leu Tyr Phe Ile Asn Cys Gln Ser 
        115                 120                 125             


Leu Leu Gln Asp Arg Asp Thr Leu Asn Phe Phe Lys Glu Ser Lys Phe 
    130                 135                 140                 


Asp Ala Leu Phe Thr Asp Pro Ala Leu Pro Cys Gly Val Ile Leu Ala 
145                 150                 155                 160 


Glu Tyr Leu Gly Leu Pro Ser Val Tyr Leu Phe Arg Gly Phe Pro Cys 
                165                 170                 175     


Ser Leu Glu His Thr Phe Ser Arg Ser Pro Asp Pro Val Ser Tyr Ile 
            180                 185                 190         


Pro Arg Cys Tyr Thr Lys Phe Ser Asp His Met Thr Phe Ser Gln Arg 
        195                 200                 205             


Val Ala Asn Phe Leu Val Asn Leu Leu Glu Pro Tyr Leu Phe Tyr Cys 
    210                 215                 220                 


Leu Phe Ser Lys Tyr Glu Glu Leu Ala Ser Ala Val Leu Lys Arg Asp 
225                 230                 235                 240 


Val Asp Ile Ile Thr Leu Tyr Gln Lys Val Ser Val Trp Leu Leu Arg 
                245                 250                 255     


Tyr Asp Phe Val Leu Glu Tyr Pro Arg Pro Val Met Pro Asn Met Val 
            260                 265                 270         


Phe Ile Gly Gly Ile Asn Cys Lys Lys Arg Lys Asp Leu Ser Gln Glu 
        275                 280                 285             


Phe Glu Ala Tyr Ile Asn Ala Ser Gly Glu His Gly Ile Val Val Phe 
    290                 295                 300                 


Ser Leu Gly Ser Met Val Ser Glu Ile Pro Glu Lys Lys Ala Met Ala 
305                 310                 315                 320 


Ile Ala Asp Ala Leu Gly Lys Ile Pro Gln Thr Val Leu Trp Arg Tyr 
                325                 330                 335     


Thr Gly Thr Arg Pro Ser Asn Leu Ala Asn Asn Thr Ile Leu Val Lys 
            340                 345                 350         


Trp Leu Pro Gln Asn Asp Leu Leu Gly His Pro Met Thr Arg Ala Phe 
        355                 360                 365             


Ile Thr His Ala Gly Ser His Gly Val Tyr Glu Ser Ile Cys Asn Gly 
    370                 375                 380                 


Val Pro Met Val Met Met Pro Leu Phe Gly Asp Gln Met Asp Asn Ala 
385                 390                 395                 400 


Lys Arg Met Glu Thr Lys Gly Ala Gly Val Thr Leu Asn Val Leu Glu 
                405                 410                 415     


Met Thr Ser Glu Asp Leu Glu Asn Ala Leu Lys Ala Val Ile Asn Asp 
            420                 425                 430         


Lys Ser Tyr Lys Glu Asn Ile Met Arg Leu Ser Ser Leu His Lys Asp 
        435                 440                 445             


Arg Pro Val Glu Pro Leu Asp Leu Ala Val Phe Trp Val Glu Phe Val 
    450                 455                 460                 


Met Arg His Lys Gly Ala Pro His Leu Arg Pro Ala Ala His Asp Leu 
465                 470                 475                 480 


Thr Trp Tyr Gln Tyr His Ser Leu Asp Val Ile Gly Phe Leu Leu Ala 
                485                 490                 495     


Val Val Leu Thr Val Ala Phe Ile Thr Phe Lys Cys Cys Ala Tyr Gly 
            500                 505                 510         


Tyr Arg Lys Cys Leu Gly Lys Lys Gly Arg Val Lys Lys Ala His Lys 
        515                 520                 525             


Ser Lys Thr His 
    530         


<210>  205
<211>  1440
<212>  DNA
<213>  Homosapiens

<400>  205
gggagaggta gacaggacct gtgaaaagca gtggttagtt tagggaaaat acctaggagc     60

cctgtgattt ggagagtgaa aactctttat taccgttgtt actttaactc tttccaggat    120

ggcctgcctc cttcgctcat ttcagagaat ttctgcaggg gttttcttct tagcactttg    180

gggcatggtt gtaggtgaca agctgctggt ggtccctcag gacggaagcc actggcttag    240

tatgaaggat atagttgagg ttctcagtga ccggggtcat gagattgtag tggtggtgcc    300

tgaagttaat ttgcttttga aagaatccaa atactacaca agaaaaatct atccagtgcc    360

gtatgaccaa gaagagctga agaaccgtta ccaatcattt ggaaacaatc actttgctga    420

gcgatcattc ctaactgctc ctcagacaga gtacaggaat aacatgattg ttattggcct    480

gtacttcatc aactgccaga gcctcctgca ggacagggac accctgaact tctttaagga    540

gagcaagttt gatgctcttt tcacagaccc agccttaccc tgtggggtga tcctggctga    600

gtatttgggc ctaccatctg tgtacctctt caggggtttt ccgtgttccc tggagcatac    660

attcagcaga agcccagacc ctgtgtccta cattcccagg tgctacacaa agttttcaga    720

ccacatgact ttttcccaac gagtggccaa cttccttgtt aatttgttgg agccctatct    780

attttattgt ctgttttcaa agtatgaaga actcgcatca gctgtcctca agagagatgt    840

ggatataatc accttatatc agaaggtctc tgtttggctg ttaagatatg actttgtgct    900

tgaatatcct aggccggtca tgcccaacat ggtcttcatt ggaggtatca actgtaagaa    960

gaggaaagac ttgtctcagg tcttgtgtgg agctactaca taatgaggcc ctgatcaggc   1020

acctgaatgc tacttccttt gatgtggttt taacagaccc cgttaacctc tgcgcggcag   1080

tgctggctaa gtacctgtcg attcctactg tgtttttttt gaggaacatt ccatgtgatt   1140

tagactttaa gggcacacag tgtccaaacc cttcctccta tattcctaga ttactaacaa   1200

ccaattcaga ccacatgaca ttcatgcaaa gggtcaagaa catgctctac cctctggccc   1260

tgtcctacat ttgccatgct ttttctgctc cttatgcaag ccttgcctct gagctttttc   1320

agagagaggt gtcagtggtg gatattctca gtcatgcatc tgtgtggctg ttccgagggg   1380

actttgtgat ggactacccc aggccaatca tgcccaacat ggtcttcatt gggggcatca   1440


<210>  206
<211>  294
<212>  PRT
<213>  Homosapiens

<400>  206

Met Ala Cys Leu Leu Arg Ser Phe Gln Arg Ile Ser Ala Gly Val Phe 
1               5                   10                  15      


Phe Leu Ala Leu Trp Gly Met Val Val Gly Asp Lys Leu Leu Val Val 
            20                  25                  30          


Pro Gln Asp Gly Ser His Trp Leu Ser Met Lys Asp Ile Val Glu Val 
        35                  40                  45              


Leu Ser Asp Arg Gly His Glu Ile Val Val Val Val Pro Glu Val Asn 
    50                  55                  60                  


Leu Leu Leu Lys Glu Ser Lys Tyr Tyr Thr Arg Lys Ile Tyr Pro Val 
65                  70                  75                  80  


Pro Tyr Asp Gln Glu Glu Leu Lys Asn Arg Tyr Gln Ser Phe Gly Asn 
                85                  90                  95      


Asn His Phe Ala Glu Arg Ser Phe Leu Thr Ala Pro Gln Thr Glu Tyr 
            100                 105                 110         


Arg Asn Asn Met Ile Val Ile Gly Leu Tyr Phe Ile Asn Cys Gln Ser 
        115                 120                 125             


Leu Leu Gln Asp Arg Asp Thr Leu Asn Phe Phe Lys Glu Ser Lys Phe 
    130                 135                 140                 


Asp Ala Leu Phe Thr Asp Pro Ala Leu Pro Cys Gly Val Ile Leu Ala 
145                 150                 155                 160 


Glu Tyr Leu Gly Leu Pro Ser Val Tyr Leu Phe Arg Gly Phe Pro Cys 
                165                 170                 175     


Ser Leu Glu His Thr Phe Ser Arg Ser Pro Asp Pro Val Ser Tyr Ile 
            180                 185                 190         


Pro Arg Cys Tyr Thr Lys Phe Ser Asp His Met Thr Phe Ser Gln Arg 
        195                 200                 205             


Val Ala Asn Phe Leu Val Asn Leu Leu Glu Pro Tyr Leu Phe Tyr Cys 
    210                 215                 220                 


Leu Phe Ser Lys Tyr Glu Glu Leu Ala Ser Ala Val Leu Lys Arg Asp 
225                 230                 235                 240 


Val Asp Ile Ile Thr Leu Tyr Gln Lys Val Ser Val Trp Leu Leu Arg 
                245                 250                 255     


Tyr Asp Phe Val Leu Glu Tyr Pro Arg Pro Val Met Pro Asn Met Val 
            260                 265                 270         


Phe Ile Gly Gly Ile Asn Cys Lys Lys Arg Lys Asp Leu Ser Gln Val 
        275                 280                 285             


Leu Cys Gly Ala Thr Thr 
    290                 


<210>  207
<211>  2161
<212>  DNA
<213>  Homosapiens

<400>  207
gggagaggta gacaggacct gtgaaaagca gtggttagtt tagggaaaat acctaggagc     60

cctgtgattt ggagagtgaa aactctttat taccgttgtt actttaactc tttccaggat    120

ggcctgcctc cttcgctcat ttcagagaat ttctgcaggg gttttcttct tagcactttg    180

gggcatggtt gtaggtgaca agctgctggt ggtccctcag gacggaagcc actggcttag    240

tatgaaggat atagttgagg ttctcagtga ccggggtcat gagattgtag tggtggtgcc    300

tgaagttaat ttgcttttga aagaatccaa atactacaca agaaaaatct atccagtgcc    360

gtatgaccaa gaagagctga agaaccgtta ccaatcattt ggaaacaatc actttgctga    420

gcgatcattc ctaactgctc ctcagacaga gtacaggaat aacatgattg ttattggcct    480

gtacttcatc aactgccaga gcctcctgca ggacagggac accctgaact tctttaagga    540

gagcaagttt gatgctcttt tcacagaccc agccttaccc tgtggggtga tcctggctga    600

gtatttgggc ctaccatctg tgtacctctt caggggtttt ccgtgttccc tggagcatac    660

attcagcaga agcccagacc ctgtgtccta cattcccagg tgctacacaa agttttcaga    720

ccacatgact ttttcccaac gagtggccaa cttccttgtt aatttgttgg agccctatct    780

attttattgt ctgttttcaa agtatgaaga actcgcatca gctgtcctca agagagatgt    840

ggatataatc accttatatc agaaggtctc tgtttggctg ttaagatatg actttgtgct    900

tgaatatcct aggccggtca tgcccaacat ggtcttcatt ggaggtatca actgtaagaa    960

gaggaaagac ttgtctcagg aatttgaagc ctacattaat gcttctggag aacatggaat   1020

tgtggttttc tctttgggat caatggtctc agaaattcca gagaagaaag ctatggcaat   1080

tgctgatgct ttgggcaaaa tccctcagac agtcctgtgg cggtacactg gaacccgacc   1140

atcgaatctt gcgaacaaca cgatacttgt taagtggcta ccccaaaacg atctgcttgg   1200

tcacccgatg acccgtgcct ttatcaccca tgctggttcc catggtgttt atgaaagcat   1260

atgcaatggc gttcccatgg tgatgatgcc cttgtttggt gatcagatgg acaatgcaaa   1320

gcgcatggag actaagggag ctggagtgac cctgaatgtt ctggaaatga cttctgaaga   1380

tttagaaaat gctctaaaag cagtcatcaa tgacaaaaga aagaagcagc agtcaggaag   1440

acagatgtga agagctggag catgttcaga tgagaggaga cggaacacgg ggacacacca   1500

gcttgagcaa gggacaacag gggaggactg atgactgact tcccaccttt gaggtgctaa   1560

tgtgtgtgtg gtggcactgg ataaaagatc aatgttggct aggcaccatg gcacacgcct   1620

gtagtcccag ccactctgga ggctaaggcg ggaggattgc ttgagcccag aagttggagg   1680

ctgctatgag ccgtgatcat gccactgcac tccagcaacc tgggcaacag agtgagaccc   1740

tgtctcaaaa aaaaaaaaaa aaatgaaaag tccacataac ctgagcatca tgtgcccaga   1800

gcgttgggtg gtgtggtccc attccttcct tccagcggct tcttctggcc acctcaatgt   1860

caggatgtcc tgctcacata tcaataccat taaaacctga cttctttccc tgcactgttg   1920

aagctccttc ttgaggctca cattatggat ataattttga ttctttcttc agtggtatag   1980

ataactactt gtaacctaag aacaacttgg tgaaagtcct ctaatacatt attttttaaa   2040

aaaacacaaa tcaatgagct caacttatta actaactttc atctattcat ttttgagcca   2100

tccctgtctg attgtgaatc tccatgattc caacactctg agctggggat agtgcctaca   2160

c                                                                   2161


<210>  208
<211>  443
<212>  PRT
<213>  Homosapiens

<400>  208

Met Ala Cys Leu Leu Arg Ser Phe Gln Arg Ile Ser Ala Gly Val Phe 
1               5                   10                  15      


Phe Leu Ala Leu Trp Gly Met Val Val Gly Asp Lys Leu Leu Val Val 
            20                  25                  30          


Pro Gln Asp Gly Ser His Trp Leu Ser Met Lys Asp Ile Val Glu Val 
        35                  40                  45              


Leu Ser Asp Arg Gly His Glu Ile Val Val Val Val Pro Glu Val Asn 
    50                  55                  60                  


Leu Leu Leu Lys Glu Ser Lys Tyr Tyr Thr Arg Lys Ile Tyr Pro Val 
65                  70                  75                  80  


Pro Tyr Asp Gln Glu Glu Leu Lys Asn Arg Tyr Gln Ser Phe Gly Asn 
                85                  90                  95      


Asn His Phe Ala Glu Arg Ser Phe Leu Thr Ala Pro Gln Thr Glu Tyr 
            100                 105                 110         


Arg Asn Asn Met Ile Val Ile Gly Leu Tyr Phe Ile Asn Cys Gln Ser 
        115                 120                 125             


Leu Leu Gln Asp Arg Asp Thr Leu Asn Phe Phe Lys Glu Ser Lys Phe 
    130                 135                 140                 


Asp Ala Leu Phe Thr Asp Pro Ala Leu Pro Cys Gly Val Ile Leu Ala 
145                 150                 155                 160 


Glu Tyr Leu Gly Leu Pro Ser Val Tyr Leu Phe Arg Gly Phe Pro Cys 
                165                 170                 175     


Ser Leu Glu His Thr Phe Ser Arg Ser Pro Asp Pro Val Ser Tyr Ile 
            180                 185                 190         


Pro Arg Cys Tyr Thr Lys Phe Ser Asp His Met Thr Phe Ser Gln Arg 
        195                 200                 205             


Val Ala Asn Phe Leu Val Asn Leu Leu Glu Pro Tyr Leu Phe Tyr Cys 
    210                 215                 220                 


Leu Phe Ser Lys Tyr Glu Glu Leu Ala Ser Ala Val Leu Lys Arg Asp 
225                 230                 235                 240 


Val Asp Ile Ile Thr Leu Tyr Gln Lys Val Ser Val Trp Leu Leu Arg 
                245                 250                 255     


Tyr Asp Phe Val Leu Glu Tyr Pro Arg Pro Val Met Pro Asn Met Val 
            260                 265                 270         


Phe Ile Gly Gly Ile Asn Cys Lys Lys Arg Lys Asp Leu Ser Gln Glu 
        275                 280                 285             


Phe Glu Ala Tyr Ile Asn Ala Ser Gly Glu His Gly Ile Val Val Phe 
    290                 295                 300                 


Ser Leu Gly Ser Met Val Ser Glu Ile Pro Glu Lys Lys Ala Met Ala 
305                 310                 315                 320 


Ile Ala Asp Ala Leu Gly Lys Ile Pro Gln Thr Val Leu Trp Arg Tyr 
                325                 330                 335     


Thr Gly Thr Arg Pro Ser Asn Leu Ala Asn Asn Thr Ile Leu Val Lys 
            340                 345                 350         


Trp Leu Pro Gln Asn Asp Leu Leu Gly His Pro Met Thr Arg Ala Phe 
        355                 360                 365             


Ile Thr His Ala Gly Ser His Gly Val Tyr Glu Ser Ile Cys Asn Gly 
    370                 375                 380                 


Val Pro Met Val Met Met Pro Leu Phe Gly Asp Gln Met Asp Asn Ala 
385                 390                 395                 400 


Lys Arg Met Glu Thr Lys Gly Ala Gly Val Thr Leu Asn Val Leu Glu 
                405                 410                 415     


Met Thr Ser Glu Asp Leu Glu Asn Ala Leu Lys Ala Val Ile Asn Asp 
            420                 425                 430         


Lys Arg Lys Lys Gln Gln Ser Gly Arg Gln Met 
        435                 440             


<210>  209
<211>  1044
<212>  DNA
<213>  Homosapiens

<400>  209
atggccacag gactccaggt tcccctgccg cagctggcca caggactgct gcttctcctc     60

agtgtccagc cctgggctga gagtgggaag gtgctggtgg tgcccactga tggcagccac    120

tggctcagca tgcgggaggc cttgcgggac ctccatgcga gaggccacca ggtggtggtc    180

ctcaccctgg aggtgaatat gtacatcaaa gaagagaact ttttcaccct gacaacgtat    240

gccatttcat ggacccagga cgaatttgat cgccttttgc tgggtcacac tcaatcgttc    300

tttgaaacag aacatcttct gatgaaattt tctagaagaa tggcaattat gaacaatatg    360

tctttgatca tacataggtc ttgtgtggag ctactgcata atgaggccct gatcaggcac    420

ctgcatgcta cttcctttga tgtggttcta acagacccct ttcacctctg cgcggcggtg    480

ctggctaagt acctgtcgat tcctgctgtg tttttcttga ggaacattcc atgtgattta    540

gactttaagg gcacacagtg tccaaaccct tcctcctata ttcctagatt actaacgacc    600

aattcagacc acatgacatt cctgcaaagg gtcaagaaca tgctctaccc tctggccctg    660

tcctaccttt gccatgctgt ttctgctcct tatgcaagcc ttgcctctga gctttttcag    720

agagaggtgt cagtggtgga tcttgtcagc catgcatctg tgtggctgtt ccgaggggac    780

tttgtgatgg attaccccag gccgatcatg cccaacatgg tcttcattgg gggcatcaac    840

tgtgccaacg ggaagccact atctcaggat gaaataaagg cctggatgaa tggatacttc    900

agtctctatg cagacttgca gaagactgga gcctttggca ttcagaagag gaattcagac    960

tgtgcaagat ctgaggccag gctccagctc cccaggtcct ttggtgagca ggagctccct   1020

gaacccaccg tgggtccttg ctag                                          1044


<210>  210
<211>  347
<212>  PRT
<213>  Homosapiens

<400>  210

Met Ala Thr Gly Leu Gln Val Pro Leu Pro Gln Leu Ala Thr Gly Leu 
1               5                   10                  15      


Leu Leu Leu Leu Ser Val Gln Pro Trp Ala Glu Ser Gly Lys Val Leu 
            20                  25                  30          


Val Val Pro Thr Asp Gly Ser His Trp Leu Ser Met Arg Glu Ala Leu 
        35                  40                  45              


Arg Asp Leu His Ala Arg Gly His Gln Val Val Val Leu Thr Leu Glu 
    50                  55                  60                  


Val Asn Met Tyr Ile Lys Glu Glu Asn Phe Phe Thr Leu Thr Thr Tyr 
65                  70                  75                  80  


Ala Ile Ser Trp Thr Gln Asp Glu Phe Asp Arg Leu Leu Leu Gly His 
                85                  90                  95      


Thr Gln Ser Phe Phe Glu Thr Glu His Leu Leu Met Lys Phe Ser Arg 
            100                 105                 110         


Arg Met Ala Ile Met Asn Asn Met Ser Leu Ile Ile His Arg Ser Cys 
        115                 120                 125             


Val Glu Leu Leu His Asn Glu Ala Leu Ile Arg His Leu His Ala Thr 
    130                 135                 140                 


Ser Phe Asp Val Val Leu Thr Asp Pro Phe His Leu Cys Ala Ala Val 
145                 150                 155                 160 


Leu Ala Lys Tyr Leu Ser Ile Pro Ala Val Phe Phe Leu Arg Asn Ile 
                165                 170                 175     


Pro Cys Asp Leu Asp Phe Lys Gly Thr Gln Cys Pro Asn Pro Ser Ser 
            180                 185                 190         


Tyr Ile Pro Arg Leu Leu Thr Thr Asn Ser Asp His Met Thr Phe Leu 
        195                 200                 205             


Gln Arg Val Lys Asn Met Leu Tyr Pro Leu Ala Leu Ser Tyr Leu Cys 
    210                 215                 220                 


His Ala Val Ser Ala Pro Tyr Ala Ser Leu Ala Ser Glu Leu Phe Gln 
225                 230                 235                 240 


Arg Glu Val Ser Val Val Asp Leu Val Ser His Ala Ser Val Trp Leu 
                245                 250                 255     


Phe Arg Gly Asp Phe Val Met Asp Tyr Pro Arg Pro Ile Met Pro Asn 
            260                 265                 270         


Met Val Phe Ile Gly Gly Ile Asn Cys Ala Asn Gly Lys Pro Leu Ser 
        275                 280                 285             


Gln Asp Glu Ile Lys Ala Trp Met Asn Gly Tyr Phe Ser Leu Tyr Ala 
    290                 295                 300                 


Asp Leu Gln Lys Thr Gly Ala Phe Gly Ile Gln Lys Arg Asn Ser Asp 
305                 310                 315                 320 


Cys Ala Arg Ser Glu Ala Arg Leu Gln Leu Pro Arg Ser Phe Gly Glu 
                325                 330                 335     


Gln Glu Leu Pro Glu Pro Thr Val Gly Pro Cys 
            340                 345         


<210>  211
<211>  2356
<212>  DNA
<213>  Homosapiens

<400>  211
atggccacag gactccaggt tcccctgccg cagctggcca caggactgct gcttctcctc     60

agtgtccagc cctgggctga gagtgggaag gtgctggtgg tgcccactga tggcagccac    120

tggctcagca tgcgggaggc cttgcgggac ctccatgcga gaggccacca ggtggtggtc    180

ctcaccctgg aggtgaatat gtacatcaaa gaagagaact ttttcaccct gacaacgtat    240

gccatttcat ggacccagga cgaatttgat cgccttttgc tgggtcacac tcaatcgttc    300

tttgaaacag aacatcttct gatgaaattt tctagaagaa tggcaattat gaacaatatg    360

tctttgatca tacataggtc ttgtgtggag ctactgcata atgaggccct gatcaggcac    420

ctgcatgcta cttcctttga tgtggttcta acagacccct ttcacctctg cgcggcggtg    480

ctggctaagt acctgtcgat tcctgctgtg tttttcttga ggaacattcc atgtgattta    540

gactttaagg gcacacagtg tccaaaccct tcctcctata ttcctagatt actaacgacc    600

aattcagacc acatgacatt cctgcaaagg gtcaagaaca tgctctaccc tctggccctg    660

tcctaccttt gccatgctgt ttctgctcct tatgcaagcc ttgcctctga gctttttcag    720

agagaggtgt cagtggtgga tcttgtcagc catgcatctg tgtggctgtt ccgaggggac    780

tttgtgatgg attaccccag gccgatcatg cccaacatgg tcttcattgg gggcatcaac    840

tgtgccaacg ggaagccact atctcaggaa tttgaagcct acattaatgc ttctggagaa    900

catggaattg tggttttctc tttgggatca atggtctcag aaattccaga gaagaaagct    960

atggcaattg ctgatgcttt gggcaaaatc cctcagacag tcctgtggcg gtacactgga   1020

acccgaccat cgaatcttgc gaacaacacg atacttgtta agtggctacc ccaaaacgat   1080

ctgcttggtc acccgatgac ccgtgccttt atcacccatg ctggttccca tggtgtttat   1140

gaaagcatat gcaatggcgt tcccatggtg atgatgccct tgtttggtga tcagatggac   1200

aatgcaaagc gcatggagac taagggagct ggagtgaccc tgaatgttct ggaaatgact   1260

tctgaagatt tagaaaatgc tctaaaagca gtcatcaatg acaaaagtta caaggagaac   1320

atcatgcgcc tctccagcct tcacaaggac cgcccggtgg agccgctgga cctggccgtg   1380

ttctgggtgg agtttgtgat gaggcacaag ggcgcgccac acctgcgccc cgcagcccac   1440

gacctcacct ggtaccagta ccattccttg gacgtgattg gtttcctctt ggccgtcgtg   1500

ctgacagtgg ccttcatcac ctttaaatgt tgtgcttatg gctaccggaa atgcttgggg   1560

aaaaaagggc gagttaagaa agcccacaaa tccaagaccc attgagaagt gggtgggaaa   1620

taaggtaaaa ttttgaacca ttccctagtc atttccaaac ttgaaaacag aatcagtgtt   1680

aaattcattt tattcttatt aaggaaatac tttgcataaa ttaatcagcc ccagagtgct   1740

ttaaaaaatt ctcttaaata aaaataatag actcgctagt cagtaaagat atttgaatat   1800

gtatcgtgcc ccctctggtg tctttgatca ggatgacatg tgccattttt cagaggacgt   1860

gcagacaggc tggcattcta gattactttt cttactctga aacatggcct gtttgggagt   1920

gcgggattca aaggtggtcc cacggctgcc cctactgcaa atggcagttt taatcttatc   1980

ttttggcttc tgcagatggt tgcaattgat ccttaaccaa taatggtcag tcctcatctc   2040

tgtcgtgctt cataggtgcc accttgtgtg tttaaagaag ggaagctttg tacctttaga   2100

gtgtaggtga aatgaatgaa tggcttggag tgcactgaga acagcatatg atttcttgct   2160

ttggggaaaa agaatgatgc tatgaaattg gtgggtggtg tatttgagaa gataatcatt   2220

gcttatgtca aatggagctg aatttgataa aaacccaaaa tacagctatg aagtgctggg   2280

caagtttact ttttttctga tgtttcctac aactaaaaat aaattaataa atttatataa   2340

attctattta agtgtt                                                   2356


<210>  212
<211>  534
<212>  PRT
<213>  Homosapiens

<400>  212

Met Ala Thr Gly Leu Gln Val Pro Leu Pro Gln Leu Ala Thr Gly Leu 
1               5                   10                  15      


Leu Leu Leu Leu Ser Val Gln Pro Trp Ala Glu Ser Gly Lys Val Leu 
            20                  25                  30          


Val Val Pro Thr Asp Gly Ser His Trp Leu Ser Met Arg Glu Ala Leu 
        35                  40                  45              


Arg Asp Leu His Ala Arg Gly His Gln Val Val Val Leu Thr Leu Glu 
    50                  55                  60                  


Val Asn Met Tyr Ile Lys Glu Glu Asn Phe Phe Thr Leu Thr Thr Tyr 
65                  70                  75                  80  


Ala Ile Ser Trp Thr Gln Asp Glu Phe Asp Arg Leu Leu Leu Gly His 
                85                  90                  95      


Thr Gln Ser Phe Phe Glu Thr Glu His Leu Leu Met Lys Phe Ser Arg 
            100                 105                 110         


Arg Met Ala Ile Met Asn Asn Met Ser Leu Ile Ile His Arg Ser Cys 
        115                 120                 125             


Val Glu Leu Leu His Asn Glu Ala Leu Ile Arg His Leu His Ala Thr 
    130                 135                 140                 


Ser Phe Asp Val Val Leu Thr Asp Pro Phe His Leu Cys Ala Ala Val 
145                 150                 155                 160 


Leu Ala Lys Tyr Leu Ser Ile Pro Ala Val Phe Phe Leu Arg Asn Ile 
                165                 170                 175     


Pro Cys Asp Leu Asp Phe Lys Gly Thr Gln Cys Pro Asn Pro Ser Ser 
            180                 185                 190         


Tyr Ile Pro Arg Leu Leu Thr Thr Asn Ser Asp His Met Thr Phe Leu 
        195                 200                 205             


Gln Arg Val Lys Asn Met Leu Tyr Pro Leu Ala Leu Ser Tyr Leu Cys 
    210                 215                 220                 


His Ala Val Ser Ala Pro Tyr Ala Ser Leu Ala Ser Glu Leu Phe Gln 
225                 230                 235                 240 


Arg Glu Val Ser Val Val Asp Leu Val Ser His Ala Ser Val Trp Leu 
                245                 250                 255     


Phe Arg Gly Asp Phe Val Met Asp Tyr Pro Arg Pro Ile Met Pro Asn 
            260                 265                 270         


Met Val Phe Ile Gly Gly Ile Asn Cys Ala Asn Gly Lys Pro Leu Ser 
        275                 280                 285             


Gln Glu Phe Glu Ala Tyr Ile Asn Ala Ser Gly Glu His Gly Ile Val 
    290                 295                 300                 


Val Phe Ser Leu Gly Ser Met Val Ser Glu Ile Pro Glu Lys Lys Ala 
305                 310                 315                 320 


Met Ala Ile Ala Asp Ala Leu Gly Lys Ile Pro Gln Thr Val Leu Trp 
                325                 330                 335     


Arg Tyr Thr Gly Thr Arg Pro Ser Asn Leu Ala Asn Asn Thr Ile Leu 
            340                 345                 350         


Val Lys Trp Leu Pro Gln Asn Asp Leu Leu Gly His Pro Met Thr Arg 
        355                 360                 365             


Ala Phe Ile Thr His Ala Gly Ser His Gly Val Tyr Glu Ser Ile Cys 
    370                 375                 380                 


Asn Gly Val Pro Met Val Met Met Pro Leu Phe Gly Asp Gln Met Asp 
385                 390                 395                 400 


Asn Ala Lys Arg Met Glu Thr Lys Gly Ala Gly Val Thr Leu Asn Val 
                405                 410                 415     


Leu Glu Met Thr Ser Glu Asp Leu Glu Asn Ala Leu Lys Ala Val Ile 
            420                 425                 430         


Asn Asp Lys Ser Tyr Lys Glu Asn Ile Met Arg Leu Ser Ser Leu His 
        435                 440                 445             


Lys Asp Arg Pro Val Glu Pro Leu Asp Leu Ala Val Phe Trp Val Glu 
    450                 455                 460                 


Phe Val Met Arg His Lys Gly Ala Pro His Leu Arg Pro Ala Ala His 
465                 470                 475                 480 


Asp Leu Thr Trp Tyr Gln Tyr His Ser Leu Asp Val Ile Gly Phe Leu 
                485                 490                 495     


Leu Ala Val Val Leu Thr Val Ala Phe Ile Thr Phe Lys Cys Cys Ala 
            500                 505                 510         


Tyr Gly Tyr Arg Lys Cys Leu Gly Lys Lys Gly Arg Val Lys Lys Ala 
        515                 520                 525             


His Lys Ser Lys Thr His 
    530                 


<210>  213
<211>  2399
<212>  DNA
<213>  Homosapiens

<400>  213
acagcgtggg gtggacagtc agctgtcggt ggcttctgct gagatggcca gaggactcca     60

ggttcccctg ccgcggctgg ccacaggact gctgctcctc ctcagtgtcc agccctgggc    120

tgagagtgga aaggtgttgg tggtgcccac tgatggcagc ccctggctca gcatgcggga    180

ggccttgcgg gagctccatg ccagaggcca ccaggcggtg gtcctcaccc cagaggtgaa    240

tatgcacatc aaagaagaga aatttttcac cctgacagcc tatgctgttc catggaccca    300

gaaggaattt gatcgcgtta cgctgggcta cactcaaggg ttctttgaaa cagaacatct    360

tctgaagaga tattctagaa gtatggcaat tatgaacaat gtatctttgg cccttcatag    420

gtgttgtgtg gagctactgc ataatgaggc cctgatcagg cacctgaatg ctacttcctt    480

tgatgtggtt ttaacagacc ccgttaacct ctgtggggcg gtgctggcta agtacctgtc    540

gattcctgct gtgttttttt ggaggtacat tccatgtgac ttagacttta agggcacaca    600

gtgtccaaat ccttcctcct atattcctaa gttactaacg accaattcag accacatgac    660

attcctgcaa agggtcaaga acatgctcta ccctctggcc ctgtcctaca tttgccatac    720

tttttctgcc ccttatgcaa gtcttgcctc tgagcttttt cagagagagg tgtcagtggt    780

ggatcttgtc agctatgcat ccgtgtggct gttccgaggg gactttgtga tggactaccc    840

caggccgatc atgcccaaca tggtcttcat tgggggcatc aactgtgcca acgggaagcc    900

actatctcag gaatttgaag cctacattaa tgcttctgga gaacatggaa ttgtggtttt    960

ctctttggga tcaatggtct cagaaattcc agagaagaaa gctatggcaa ttgctgatgc   1020

tttgggcaaa atccctcaga cagtcctgtg gcggtacact ggaacccgac catcgaatct   1080

tgcgaacaac acgatacttg ttaagtggct accccaaaac gatctgcttg gtcacccgat   1140

gacccgtgcc tttatcaccc atgctggttc ccatggtgtt tatgaaagca tatgcaatgg   1200

cgttcccatg gtgatgatgc ccttgtttgg tgatcagatg gacaatgcaa agcgcatgga   1260

gactaaggga gctggagtga ccctgaatgt tctggaaatg acttctgaag atttagaaaa   1320

tgctctaaaa gcagtcatca atgacaaaag ttacaaggag aacatcatgc gcctctccag   1380

ccttcacaag gaccgcccgg tggagccgct ggacctggcc gtgttctggg tggagtttgt   1440

gatgaggcac aagggcgcgc cacacctgcg ccccgcagcc cacgacctca cctggtacca   1500

gtaccattcc ttggacgtga ttggtttcct cttggccgtc gtgctgacag tggccttcat   1560

cacctttaaa tgttgtgctt atggctaccg gaaatgcttg gggaaaaaag ggcgagttaa   1620

gaaagcccac aaatccaaga cccattgaga agtgggtggg aaataaggta aaattttgaa   1680

ccattcccta gtcatttcca aacttgaaaa cagaatcagt gttaaattca ttttattctt   1740

attaaggaaa tactttgcat aaattaatca gccccagagt gctttaaaaa attctcttaa   1800

ataaaaataa tagactcgct agtcagtaaa gatatttgaa tatgtatcgt gccccctctg   1860

gtgtctttga tcaggatgac atgtgccatt tttcagagga cgtgcagaca ggctggcatt   1920

ctagattact tttcttactc tgaaacatgg cctgtttggg agtgcgggat tcaaaggtgg   1980

tcccacggct gcccctactg caaatggcag ttttaatctt atcttttggc ttctgcagat   2040

ggttgcaatt gatccttaac caataatggt cagtcctcat ctctgtcgtg cttcataggt   2100

gccaccttgt gtgtttaaag aagggaagct ttgtaccttt agagtgtagg tgaaatgaat   2160

gaatggcttg gagtgcactg agaacagcat atgatttctt gctttgggga aaaagaatga   2220

tgctatgaaa ttggtgggtg gtgtatttga gaagataatc attgcttatg tcaaatggag   2280

ctgaatttga taaaaaccca aaatacagct atgaagtgct gggcaagttt actttttttc   2340

tgatgtttcc tacaactaaa aataaattaa taaatttata taaattctat ttaagtgtt    2399


<210>  214
<211>  534
<212>  PRT
<213>  Homosapiens

<400>  214

Met Ala Arg Gly Leu Gln Val Pro Leu Pro Arg Leu Ala Thr Gly Leu 
1               5                   10                  15      


Leu Leu Leu Leu Ser Val Gln Pro Trp Ala Glu Ser Gly Lys Val Leu 
            20                  25                  30          


Val Val Pro Thr Asp Gly Ser Pro Trp Leu Ser Met Arg Glu Ala Leu 
        35                  40                  45              


Arg Glu Leu His Ala Arg Gly His Gln Ala Val Val Leu Thr Pro Glu 
    50                  55                  60                  


Val Asn Met His Ile Lys Glu Glu Lys Phe Phe Thr Leu Thr Ala Tyr 
65                  70                  75                  80  


Ala Val Pro Trp Thr Gln Lys Glu Phe Asp Arg Val Thr Leu Gly Tyr 
                85                  90                  95      


Thr Gln Gly Phe Phe Glu Thr Glu His Leu Leu Lys Arg Tyr Ser Arg 
            100                 105                 110         


Ser Met Ala Ile Met Asn Asn Val Ser Leu Ala Leu His Arg Cys Cys 
        115                 120                 125             


Val Glu Leu Leu His Asn Glu Ala Leu Ile Arg His Leu Asn Ala Thr 
    130                 135                 140                 


Ser Phe Asp Val Val Leu Thr Asp Pro Val Asn Leu Cys Gly Ala Val 
145                 150                 155                 160 


Leu Ala Lys Tyr Leu Ser Ile Pro Ala Val Phe Phe Trp Arg Tyr Ile 
                165                 170                 175     


Pro Cys Asp Leu Asp Phe Lys Gly Thr Gln Cys Pro Asn Pro Ser Ser 
            180                 185                 190         


Tyr Ile Pro Lys Leu Leu Thr Thr Asn Ser Asp His Met Thr Phe Leu 
        195                 200                 205             


Gln Arg Val Lys Asn Met Leu Tyr Pro Leu Ala Leu Ser Tyr Ile Cys 
    210                 215                 220                 


His Thr Phe Ser Ala Pro Tyr Ala Ser Leu Ala Ser Glu Leu Phe Gln 
225                 230                 235                 240 


Arg Glu Val Ser Val Val Asp Leu Val Ser Tyr Ala Ser Val Trp Leu 
                245                 250                 255     


Phe Arg Gly Asp Phe Val Met Asp Tyr Pro Arg Pro Ile Met Pro Asn 
            260                 265                 270         


Met Val Phe Ile Gly Gly Ile Asn Cys Ala Asn Gly Lys Pro Leu Ser 
        275                 280                 285             


Gln Glu Phe Glu Ala Tyr Ile Asn Ala Ser Gly Glu His Gly Ile Val 
    290                 295                 300                 


Val Phe Ser Leu Gly Ser Met Val Ser Glu Ile Pro Glu Lys Lys Ala 
305                 310                 315                 320 


Met Ala Ile Ala Asp Ala Leu Gly Lys Ile Pro Gln Thr Val Leu Trp 
                325                 330                 335     


Arg Tyr Thr Gly Thr Arg Pro Ser Asn Leu Ala Asn Asn Thr Ile Leu 
            340                 345                 350         


Val Lys Trp Leu Pro Gln Asn Asp Leu Leu Gly His Pro Met Thr Arg 
        355                 360                 365             


Ala Phe Ile Thr His Ala Gly Ser His Gly Val Tyr Glu Ser Ile Cys 
    370                 375                 380                 


Asn Gly Val Pro Met Val Met Met Pro Leu Phe Gly Asp Gln Met Asp 
385                 390                 395                 400 


Asn Ala Lys Arg Met Glu Thr Lys Gly Ala Gly Val Thr Leu Asn Val 
                405                 410                 415     


Leu Glu Met Thr Ser Glu Asp Leu Glu Asn Ala Leu Lys Ala Val Ile 
            420                 425                 430         


Asn Asp Lys Ser Tyr Lys Glu Asn Ile Met Arg Leu Ser Ser Leu His 
        435                 440                 445             


Lys Asp Arg Pro Val Glu Pro Leu Asp Leu Ala Val Phe Trp Val Glu 
    450                 455                 460                 


Phe Val Met Arg His Lys Gly Ala Pro His Leu Arg Pro Ala Ala His 
465                 470                 475                 480 


Asp Leu Thr Trp Tyr Gln Tyr His Ser Leu Asp Val Ile Gly Phe Leu 
                485                 490                 495     


Leu Ala Val Val Leu Thr Val Ala Phe Ile Thr Phe Lys Cys Cys Ala 
            500                 505                 510         


Tyr Gly Tyr Arg Lys Cys Leu Gly Lys Lys Gly Arg Val Lys Lys Ala 
        515                 520                 525             


His Lys Ser Lys Thr His 
    530                 


<210>  215
<211>  2375
<212>  DNA
<213>  Homosapiens

<400>  215
gtccgtgtct tctgctgaga tggccacagg actccaggtt cccctgccgt ggctggccac     60

aggactgctg cttctcctca gtgtccagcc ctgggctgag agtggaaagg tgttggtggt    120

gcccattgat ggcagccact ggctcagcat gcgggaggtc ttgcgggagc tccatgccag    180

aggccaccag gcagtggtcc tcaccccaga ggtgaatatg cacatcaaag aagagaactt    240

tttcaccctg acaacctatg ccatttcgtg gacccaggat gaatttgatc gccatgtgct    300

gggccacact caactgtact ttgaaacaga acattttctg aagaaatttt tcagaagtat    360

ggcaatgttg aacaatatgt ctttggtcta tcataggtct tgtgtggagc tactacataa    420

tgaggccctg atcaggcacc tgaatgctac ttcctttgat gtggttttaa cagaccccgt    480

taacctctgc gcggcagtgc tggctaagta cctgtcgatt cctactgtgt tttttttgag    540

gaacattcca tgtgatttag actttaaggg cacacagtgt ccaaaccctt cctcctatat    600

tcctagatta ctaacaacca attcagacca catgacattc atgcaaaggg tcaagaacat    660

gctctaccct ctggccctgt cctacatttg ccatgctttt tctgctcctt atgcaagcct    720

tgcctctgag ctttttcaga gagaggtgtc agtggtggat attctcagtc atgcatctgt    780

gtggctgttc cgaggggact ttgtgatgga ctaccccagg ccaatcatgc ccaacatggt    840

cttcattggg ggcatcaact gtgccaacag gaagccacta tctcaggaat ttgaagccta    900

cattaatgct tctggagaac atggaattgt ggttttctct ttgggatcaa tggtctcaga    960

aattccagag aagaaagcta tggcaattgc tgatgctttg ggcaaaatcc ctcagacagt   1020

cctgtggcgg tacactggaa cccgaccatc gaatcttgcg aacaacacga tacttgttaa   1080

gtggctaccc caaaacgatc tgcttggtca cccgatgacc cgtgccttta tcacccatgc   1140

tggttcccat ggtgtttatg aaagcatatg caatggcgtt cccatggtga tgatgccctt   1200

gtttggtgat cagatggaca atgcaaagcg catggagact aagggagctg gagtgaccct   1260

gaatgttctg gaaatgactt ctgaagattt agaaaatgct ctaaaagcag tcatcaatga   1320

caaaagttac aaggagaaca tcatgcgcct ctccagcctt cacaaggacc gcccggtgga   1380

gccgctggac ctggccgtgt tctgggtgga gtttgtgatg aggcacaagg gcgcgccaca   1440

cctgcgcccc gcagcccacg acctcacctg gtaccagtac cattccttgg acgtgattgg   1500

tttcctcttg gccgtcgtgc tgacagtggc cttcatcacc tttaaatgtt gtgcttatgg   1560

ctaccggaaa tgcttgggga aaaaagggcg agttaagaaa gcccacaaat ccaagaccca   1620

ttgagaagtg ggtgggaaat aaggtaaaat tttgaaccat tccctagtca tttccaaact   1680

tgaaaacaga atcagtgtta aattcatttt attcttatta aggaaatact ttgcataaat   1740

taatcagccc cagagtgctt taaaaaattc tcttaaataa aaataataga ctcgctagtc   1800

agtaaagata tttgaatatg tatcgtgccc cctctggtgt ctttgatcag gatgacatgt   1860

gccatttttc agaggacgtg cagacaggct ggcattctag attacttttc ttactctgaa   1920

acatggcctg tttgggagtg cgggattcaa aggtggtccc acggctgccc ctactgcaaa   1980

tggcagtttt aatcttatct tttggcttct gcagatggtt gcaattgatc cttaaccaat   2040

aatggtcagt cctcatctct gtcgtgcttc ataggtgcca ccttgtgtgt ttaaagaagg   2100

gaagctttgt acctttagag tgtaggtgaa atgaatgaat ggcttggagt gcactgagaa   2160

cagcatatga tttcttgctt tggggaaaaa gaatgatgct atgaaattgg tgggtggtgt   2220

atttgagaag ataatcattg cttatgtcaa atggagctga atttgataaa aacccaaaat   2280

acagctatga agtgctgggc aagtttactt tttttctgat gtttcctaca actaaaaata   2340

aattaataaa tttatataaa ttctatttaa gtgtt                              2375


<210>  216
<211>  534
<212>  PRT
<213>  Homosapiens

<400>  216

Met Ala Thr Gly Leu Gln Val Pro Leu Pro Trp Leu Ala Thr Gly Leu 
1               5                   10                  15      


Leu Leu Leu Leu Ser Val Gln Pro Trp Ala Glu Ser Gly Lys Val Leu 
            20                  25                  30          


Val Val Pro Ile Asp Gly Ser His Trp Leu Ser Met Arg Glu Val Leu 
        35                  40                  45              


Arg Glu Leu His Ala Arg Gly His Gln Ala Val Val Leu Thr Pro Glu 
    50                  55                  60                  


Val Asn Met His Ile Lys Glu Glu Asn Phe Phe Thr Leu Thr Thr Tyr 
65                  70                  75                  80  


Ala Ile Ser Trp Thr Gln Asp Glu Phe Asp Arg His Val Leu Gly His 
                85                  90                  95      


Thr Gln Leu Tyr Phe Glu Thr Glu His Phe Leu Lys Lys Phe Phe Arg 
            100                 105                 110         


Ser Met Ala Met Leu Asn Asn Met Ser Leu Val Tyr His Arg Ser Cys 
        115                 120                 125             


Val Glu Leu Leu His Asn Glu Ala Leu Ile Arg His Leu Asn Ala Thr 
    130                 135                 140                 


Ser Phe Asp Val Val Leu Thr Asp Pro Val Asn Leu Cys Ala Ala Val 
145                 150                 155                 160 


Leu Ala Lys Tyr Leu Ser Ile Pro Thr Val Phe Phe Leu Arg Asn Ile 
                165                 170                 175     


Pro Cys Asp Leu Asp Phe Lys Gly Thr Gln Cys Pro Asn Pro Ser Ser 
            180                 185                 190         


Tyr Ile Pro Arg Leu Leu Thr Thr Asn Ser Asp His Met Thr Phe Met 
        195                 200                 205             


Gln Arg Val Lys Asn Met Leu Tyr Pro Leu Ala Leu Ser Tyr Ile Cys 
    210                 215                 220                 


His Ala Phe Ser Ala Pro Tyr Ala Ser Leu Ala Ser Glu Leu Phe Gln 
225                 230                 235                 240 


Arg Glu Val Ser Val Val Asp Ile Leu Ser His Ala Ser Val Trp Leu 
                245                 250                 255     


Phe Arg Gly Asp Phe Val Met Asp Tyr Pro Arg Pro Ile Met Pro Asn 
            260                 265                 270         


Met Val Phe Ile Gly Gly Ile Asn Cys Ala Asn Arg Lys Pro Leu Ser 
        275                 280                 285             


Gln Glu Phe Glu Ala Tyr Ile Asn Ala Ser Gly Glu His Gly Ile Val 
    290                 295                 300                 


Val Phe Ser Leu Gly Ser Met Val Ser Glu Ile Pro Glu Lys Lys Ala 
305                 310                 315                 320 


Met Ala Ile Ala Asp Ala Leu Gly Lys Ile Pro Gln Thr Val Leu Trp 
                325                 330                 335     


Arg Tyr Thr Gly Thr Arg Pro Ser Asn Leu Ala Asn Asn Thr Ile Leu 
            340                 345                 350         


Val Lys Trp Leu Pro Gln Asn Asp Leu Leu Gly His Pro Met Thr Arg 
        355                 360                 365             


Ala Phe Ile Thr His Ala Gly Ser His Gly Val Tyr Glu Ser Ile Cys 
    370                 375                 380                 


Asn Gly Val Pro Met Val Met Met Pro Leu Phe Gly Asp Gln Met Asp 
385                 390                 395                 400 


Asn Ala Lys Arg Met Glu Thr Lys Gly Ala Gly Val Thr Leu Asn Val 
                405                 410                 415     


Leu Glu Met Thr Ser Glu Asp Leu Glu Asn Ala Leu Lys Ala Val Ile 
            420                 425                 430         


Asn Asp Lys Ser Tyr Lys Glu Asn Ile Met Arg Leu Ser Ser Leu His 
        435                 440                 445             


Lys Asp Arg Pro Val Glu Pro Leu Asp Leu Ala Val Phe Trp Val Glu 
    450                 455                 460                 


Phe Val Met Arg His Lys Gly Ala Pro His Leu Arg Pro Ala Ala His 
465                 470                 475                 480 


Asp Leu Thr Trp Tyr Gln Tyr His Ser Leu Asp Val Ile Gly Phe Leu 
                485                 490                 495     


Leu Ala Val Val Leu Thr Val Ala Phe Ile Thr Phe Lys Cys Cys Ala 
            500                 505                 510         


Tyr Gly Tyr Arg Lys Cys Leu Gly Lys Lys Gly Arg Val Lys Lys Ala 
        515                 520                 525             


His Lys Ser Lys Thr His 
    530                 


<210>  217
<211>  749
<212>  DNA
<213>  Homosapiens

<400>  217
atagtggact actacgaggt gctgggagta ccccggtagg cctcgtccga gggtatcaag     60

aaggcgtacc gcaagctggc gctcaagtgg caccccgaca aaaaccccga ggacagggag    120

gaagcggtga gaagattcaa gcaggtggct gaggcctacg aggtgttgtc ggacgcgtag    180

aaacgcgata tctatgaccg ctatggcgag gcgagggcgg agggcggctg cgcaggcggc    240

aggcccttca aggacccctt cgagatttcg ttcctttggc tccctgggaa gtgggggcct    300

ttcttccttc tgcatgtcct acggtagtga tgggacaggc agcttcaagt ccatgtcgac    360

ttccactgaa atagttgatg gtaaaaaaat caccaccaag agaatcattg agaatggcca    420

agaaagggtg gaagtggagg aagatggaga gttgagttaa agtccttcat aataaacggc    480

atagagcagt tgctccccat tgacaccaag taattccagt ccacatttgc ctttaagcac    540

atctggagga atagcggact ttttttagga ttgaaagtga actttacttt cagaacagct    600

gtacccaaga atttataaac actttatgcc aatgcctgtc tttattgttg ggactgcacg    660

gataggacct ctgtttgtct ttcgatcatt gtaaatatct gtatgcaatt tgctatttat    720

taaacttaag cctgaggcag acaatgatt                                      749


<210>  218
<211>  88
<212>  PRT
<213>  Homosapiens

<400>  218

Met Thr Ala Met Ala Arg Arg Gly Arg Arg Ala Ala Ala Gln Ala Ala 
1               5                   10                  15      


Gly Pro Ser Arg Thr Pro Ser Arg Phe Arg Ser Phe Gly Ser Leu Gly 
            20                  25                  30          


Ser Gly Gly Leu Ser Ser Phe Cys Met Ser Tyr Gly Ser Asp Gly Thr 
        35                  40                  45              


Gly Ser Phe Lys Ser Met Ser Thr Ser Thr Glu Ile Val Asp Gly Lys 
    50                  55                  60                  


Lys Ile Thr Thr Lys Arg Ile Ile Glu Asn Gly Gln Glu Arg Val Glu 
65                  70                  75                  80  


Val Glu Glu Asp Gly Glu Leu Ser 
                85              


<210>  219
<211>  688
<212>  DNA
<213>  Homosapiens

<400>  219
ctctgacctg tgcgcgggtg ctggcagcct tgccgctcgc tgtgccagtg ccccgcaggc     60

tctttggcag tccagcatag tggactacta cgaggtgctg ggagtacccc ggtaggcctc    120

gtccgagggt atcaagaagg cgtaccgcaa gctggcgctc aagtggcacc ccgacaaaaa    180

ccccgaggac agggaggaag cggatttcgt tcctttggct ccctgggaag tgggggcctt    240

tcttccttct gcatgtccta cggtagtgat gggacaggca gcttcaagtc catgtcgact    300

tccactgaaa tagttgatgg taaaaaaatc accaccaaga gaatcattga gaatggccaa    360

gaaagggtgg aagtggagga agatggagag ttgagttaaa gtccttcata ataaacggca    420

tagagcagtt gctccccatt gacaccaagt aattccagtc cacatttgcc tttaagcaca    480

tctggaggaa tagcggactt tttttaggat tgaaagtgaa ctttactttc agaacagctg    540

tacccaagaa tttataaaca ctttatgcca atgcctgtct ttattgttgg gactgcacgg    600

ataggacctc tgtttgtctt tcgatcattg taaatatctg tatgcaattt gctatttatt    660

aaacttaagc ctgaggcaga caatgatt                                       688


<210>  220
<211>  48
<212>  PRT
<213>  Homosapiens

<400>  220

Met Ser Tyr Gly Ser Asp Gly Thr Gly Ser Phe Lys Ser Met Ser Thr 
1               5                   10                  15      


Ser Thr Glu Ile Val Asp Gly Lys Lys Ile Thr Thr Lys Arg Ile Ile 
            20                  25                  30          


Glu Asn Gly Gln Glu Arg Val Glu Val Glu Glu Asp Gly Glu Leu Ser 
        35                  40                  45              


<210>  221
<211>  2395
<212>  DNA
<213>  Homosapiens

<400>  221
ataagtagga gagggcgaac ctctggcagg agcaaaggcg ccatggctgt ggagtcccag     60

ggcggacgcc cacttgtcct gggcctgctg ctgtgtgtgc tgggcccagt ggtgtcccat    120

gctgggaaga tactgttgat cccagtggat ggcagccact ggctgagcat gcttggggcc    180

atccagcagc tgcagcagag gggacatgaa atagttgtcc tagcacctga cgcctcgttg    240

tacatcagag acggagcatt ttacaccttg aagacgtacc ctgtgccatt ccaaagggag    300

gatgtgaaag agtcttttgt tagtctcggg cataatgttt ttgagaatga ttctttcctg    360

cagcgtgtga tcaaaacata caagaaaata aaaaaggact ctgctatgct tttgtctggc    420

tgttcccact tactgcacaa caaggagctc atggcctccc tggcagaaag cagctttgat    480

gtcatgctga cggacccttt ccttccttgc agccccatcg tggcccagta cctgtctctg    540

cccactgtat tcttcttgca tgcactgcca tgcagcctgg aatttgaggc tacccagtgc    600

cccaacccat tctcctacgt gcccaggcct ctctcctctc attcagatca catgaccttc    660

ctgcagcggg tgaagaacat gctcattgcc ttttcacaga actttctgtg cgacgtggtt    720

tattccccgt atgcaaccct tgcctcagaa ttccttcaga gagaggtgac tgtccaggac    780

ctattgagct ctgcatctgt ctggctgttt agaagtgact ttgtgaagga ttaccctagg    840

cccatcatgc ccaatatggt ttttgttggt ggaatcaact gccttcacca aaatccacta    900

tcccaggaat ttgaagccta cattaatgct tctggagaac atggaattgt ggttttctct    960

ttgggatcaa tggtctcaga aattccagag aagaaagcta tggcaattgc tgatgctttg   1020

ggcaaaatcc ctcagacagt cctgtggcgg tacactggaa cccgaccatc gaatcttgcg   1080

aacaacacga tacttgttaa gtggctaccc caaaacgatc tgcttggtca cccgatgacc   1140

cgtgccttta tcacccatgc tggttcccat ggtgtttatg aaagcatatg caatggcgtt   1200

cccatggtga tgatgccctt gtttggtgat cagatggaca atgcaaagcg catggagact   1260

aagggagctg gagtgaccct gaatgttctg gaaatgactt ctgaagattt agaaaatgct   1320

ctaaaagcag tcatcaatga caaaagttac aaggagaaca tcatgcgcct ctccagcctt   1380

cacaaggacc gcccggtgga gccgctggac ctggccgtgt tctgggtgga gtttgtgatg   1440

aggcacaagg gcgcgccaca cctgcgcccc gcagcccacg acctcacctg gtaccagtac   1500

cattccttgg acgtgattgg tttcctcttg gccgtcgtgc tgacagtggc cttcatcacc   1560

tttaaatgtt gtgcttatgg ctaccggaaa tgcttgggga aaaaagggcg agttaagaaa   1620

gcccacaaat ccaagaccca ttgagaagtg ggtgggaaat aaggtaaaat tttgaaccat   1680

tccctagtca tttccaaact tgaaaacaga atcagtgtta aattcatttt attcttatta   1740

aggaaatact ttgcataaat taatcagccc cagagtgctt taaaaaattc tcttaaataa   1800

aaataataga ctcgctagtc agtaaagata tttgaatatg tatcgtgccc cctctggtgt   1860

ctttgatcag gatgacatgt gccatttttc agaggacgtg cagacaggct ggcattctag   1920

attacttttc ttactctgaa acatggcctg tttgggagtg cgggattcaa aggtggtccc   1980

acggctgccc ctactgcaaa tggcagtttt aatcttatct tttggcttct gcagatggtt   2040

gcaattgatc cttaaccaat aatggtcagt cctcatctct gtcgtgcttc ataggtgcca   2100

ccttgtgtgt ttaaagaagg gaagctttgt acctttagag tgtaggtgaa atgaatgaat   2160

ggcttggagt gcactgagaa cagcatatga tttcttgctt tggggaaaaa gaatgatgct   2220

atgaaattgg tgggtggtgt atttgagaag ataatcattg cttatgtcaa atggagctga   2280

atttgataaa aacccaaaat acagctatga agtgctgggc aagtttactt tttttctgat   2340

gtttcctaca actaaaaata aattaataaa tttatataaa ttctatttaa gtgtt        2395


<210>  222
<211>  533
<212>  PRT
<213>  Homosapiens

<400>  222

Met Ala Val Glu Ser Gln Gly Gly Arg Pro Leu Val Leu Gly Leu Leu 
1               5                   10                  15      


Leu Cys Val Leu Gly Pro Val Val Ser His Ala Gly Lys Ile Leu Leu 
            20                  25                  30          


Ile Pro Val Asp Gly Ser His Trp Leu Ser Met Leu Gly Ala Ile Gln 
        35                  40                  45              


Gln Leu Gln Gln Arg Gly His Glu Ile Val Val Leu Ala Pro Asp Ala 
    50                  55                  60                  


Ser Leu Tyr Ile Arg Asp Gly Ala Phe Tyr Thr Leu Lys Thr Tyr Pro 
65                  70                  75                  80  


Val Pro Phe Gln Arg Glu Asp Val Lys Glu Ser Phe Val Ser Leu Gly 
                85                  90                  95      


His Asn Val Phe Glu Asn Asp Ser Phe Leu Gln Arg Val Ile Lys Thr 
            100                 105                 110         


Tyr Lys Lys Ile Lys Lys Asp Ser Ala Met Leu Leu Ser Gly Cys Ser 
        115                 120                 125             


His Leu Leu His Asn Lys Glu Leu Met Ala Ser Leu Ala Glu Ser Ser 
    130                 135                 140                 


Phe Asp Val Met Leu Thr Asp Pro Phe Leu Pro Cys Ser Pro Ile Val 
145                 150                 155                 160 


Ala Gln Tyr Leu Ser Leu Pro Thr Val Phe Phe Leu His Ala Leu Pro 
                165                 170                 175     


Cys Ser Leu Glu Phe Glu Ala Thr Gln Cys Pro Asn Pro Phe Ser Tyr 
            180                 185                 190         


Val Pro Arg Pro Leu Ser Ser His Ser Asp His Met Thr Phe Leu Gln 
        195                 200                 205             


Arg Val Lys Asn Met Leu Ile Ala Phe Ser Gln Asn Phe Leu Cys Asp 
    210                 215                 220                 


Val Val Tyr Ser Pro Tyr Ala Thr Leu Ala Ser Glu Phe Leu Gln Arg 
225                 230                 235                 240 


Glu Val Thr Val Gln Asp Leu Leu Ser Ser Ala Ser Val Trp Leu Phe 
                245                 250                 255     


Arg Ser Asp Phe Val Lys Asp Tyr Pro Arg Pro Ile Met Pro Asn Met 
            260                 265                 270         


Val Phe Val Gly Gly Ile Asn Cys Leu His Gln Asn Pro Leu Ser Gln 
        275                 280                 285             


Glu Phe Glu Ala Tyr Ile Asn Ala Ser Gly Glu His Gly Ile Val Val 
    290                 295                 300                 


Phe Ser Leu Gly Ser Met Val Ser Glu Ile Pro Glu Lys Lys Ala Met 
305                 310                 315                 320 


Ala Ile Ala Asp Ala Leu Gly Lys Ile Pro Gln Thr Val Leu Trp Arg 
                325                 330                 335     


Tyr Thr Gly Thr Arg Pro Ser Asn Leu Ala Asn Asn Thr Ile Leu Val 
            340                 345                 350         


Lys Trp Leu Pro Gln Asn Asp Leu Leu Gly His Pro Met Thr Arg Ala 
        355                 360                 365             


Phe Ile Thr His Ala Gly Ser His Gly Val Tyr Glu Ser Ile Cys Asn 
    370                 375                 380                 


Gly Val Pro Met Val Met Met Pro Leu Phe Gly Asp Gln Met Asp Asn 
385                 390                 395                 400 


Ala Lys Arg Met Glu Thr Lys Gly Ala Gly Val Thr Leu Asn Val Leu 
                405                 410                 415     


Glu Met Thr Ser Glu Asp Leu Glu Asn Ala Leu Lys Ala Val Ile Asn 
            420                 425                 430         


Asp Lys Ser Tyr Lys Glu Asn Ile Met Arg Leu Ser Ser Leu His Lys 
        435                 440                 445             


Asp Arg Pro Val Glu Pro Leu Asp Leu Ala Val Phe Trp Val Glu Phe 
    450                 455                 460                 


Val Met Arg His Lys Gly Ala Pro His Leu Arg Pro Ala Ala His Asp 
465                 470                 475                 480 


Leu Thr Trp Tyr Gln Tyr His Ser Leu Asp Val Ile Gly Phe Leu Leu 
                485                 490                 495     


Ala Val Val Leu Thr Val Ala Phe Ile Thr Phe Lys Cys Cys Ala Tyr 
            500                 505                 510         


Gly Tyr Arg Lys Cys Leu Gly Lys Lys Gly Arg Val Lys Lys Ala His 
        515                 520                 525             


Lys Ser Lys Thr His 
    530             


<210>  223
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  223
tagctctgtt sctatttgcc a                                               21


<210>  224
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  224
aaaagtggtg ytagaaaact t                                               21


<210>  225
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  225
atgtgtcagc rgttgcttct t                                               21


<210>  226
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  226
gtgtttacca kgtagtgtgc t                                               21


<210>  227
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  227
taagatacac rtgaagtcaa t                                               21


<210>  228
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  228
ataactgata sgttttgaga a                                               21


<210>  229
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  229
aagaagtagc rgagctgaga a                                               21


<210>  230
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  230
accgggtgat kcatttccac a                                               21


<210>  231
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  231
ggtgccagcc rccaccagaa g                                               21


<210>  232
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  232
tcctattggc rtgaggataa c                                               21


<210>  233
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  233
aaaaccataa ygattggtgt t                                               21


<210>  234
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  234
tctcgctatc rtcttctgcc t                                               21


<210>  235
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  235
cactgcttcc mgccaccctg c                                               21


<210>  236
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  236
ataagcctct sccttctgga a                                               21


<210>  237
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  237
aagcggggtg ygatgtttgg a                                               21


<210>  238
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  238
cagggcaggg yttggggctg g                                               21


<210>  239
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  239
ggttaagtga ktgacaacag t                                               21


<210>  240
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  240
tgtttttaag rctcttgata c                                               21


<210>  241
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  241
ctggggaatg rgatgcaagt g                                               21


<210>  242
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  242
cctcctataa matccactcc t                                               21


<210>  243
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  243
tttaagaaca macattttgg a                                               21


<210>  244
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  244
aggccccatg kttccacctg c                                               21


<210>  245
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  245
gtaccaacta yctgcaaggc a                                               21


<210>  246
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  246
ttctttacga mcactgaaat t                                               21


<210>  247
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  247
gagagtggcc rgtcctagat g                                               21


<210>  248
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  248
tggtattaga wgaaacacat t                                               21


<210>  249
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  249
aacactcatg rtgtgccaag t                                               21


<210>  250
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  250
ccccagaaac rgactctgag t                                               21


<210>  251
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  251
tctcttttgg rgagaaatgg a                                               21


<210>  252
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  252
attgaaaact raaaacattt c                                               21


<210>  253
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  253
tactttgacc wggtttaact t                                               21


<210>  254
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  254
aggagtcagg yggccttccc a                                               21


<210>  255
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  255
accctggagc yggcctcctc t                                               21


<210>  256
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  256
aagaatgacg ytgatgagtg a                                               21


<210>  257
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  257
atatttgaac sttgcgtcta g                                               21


<210>  258
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  258
aaccacagag mgcatgtgtg t                                               21


<210>  259
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  259
tggagacttg ygcttccccc c                                               21


<210>  260
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  260
ctttaaaaaa yagagagtca g                                               21


<210>  261
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  261
ctggttcctt rcccggtggc t                                               21


<210>  262
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  262
ctggggaact rttggatgtc t                                               21


<210>  263
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  263
tcagtagaat rgccatgttg g                                               21


<210>  264
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  264
aaaatgatgg ytattctcat t                                               21


<210>  265
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  265
tgccagagtg wggaagaaca t                                               21


<210>  266
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  266
tccatgtaat mggtgttgta t                                               21


<210>  267
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  267
acagtcatct rccagtgcgc c                                               21


<210>  268
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  268
catgtggagc ygtgagtatc t                                               21


<210>  269
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  269
ttagtacctg rtacagattc a                                               21


<210>  270
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  270
gatataaaaa mgtatatatg a                                               21


<210>  271
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  271
gagagtataa rtgttatatc a                                               21


<210>  272
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  272
tccattaatt rtagtaacag g                                               21


<210>  273
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  273
agaattcaag mccatacatt c                                               21


<210>  274
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  274
tttttttttt waaaaacttt t                                               21


<210>  275
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  275
attgtaatag ragaatgttt c                                               21


<210>  276
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  276
cctctattcg rccatttaaa t                                               21


<210>  277
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  277
tccagatgag yttcagtgta a                                               21


