                         SEQUENCE LISTING

<110>  Emory University
 
<120>  Virosomes, Methods of Preparation, And Immunogenic Compositions

<130>  050508-2570

<150>  60/830,762
<151>  2006-07-13

<160>  11    

<170>  PatentIn version 3.4

<210>  1
<211>  847
<212>  PRT
<213>  HIV SF162 Envelope Protein

<400>  1

Met Arg Val Lys Gly Ile Arg Lys Asn Tyr Gln His Leu Trp Arg Gly 
1               5                   10                  15      


Gly Thr Leu Leu Leu Gly Met Leu Met Ile Cys Ser Ala Val Glu Lys 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Thr 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Thr Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Ile Val Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asn Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


His Cys Thr Asn Leu Lys Asn Ala Thr Asn Thr Lys Ser Ser Asn Trp 
    130                 135                 140                 


Lys Glu Met Asp Arg Gly Glu Ile Lys Asn Cys Ser Phe Lys Val Thr 
145                 150                 155                 160 


Thr Ser Ile Arg Asn Lys Met Gln Lys Glu Tyr Ala Leu Phe Tyr Lys 
                165                 170                 175     


Leu Asp Val Val Pro Ile Asp Asn Asp Asn Thr Ser Tyr Lys Leu Ile 
            180                 185                 190         


Asn Cys Asn Thr Ser Val Ile Thr Gln Ala Cys Pro Lys Val Ser Phe 
        195                 200                 205             


Glu Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Phe Ala Ile Leu 
    210                 215                 220                 


Lys Cys Asn Asp Lys Lys Phe Asn Gly Ser Gly Pro Cys Thr Asn Val 
225                 230                 235                 240 


Ser Thr Val Gln Cys Thr His Gly Ile Arg Pro Val Val Ser Thr Gln 
                245                 250                 255     


Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu Gly Val Val Ile Arg Ser 
            260                 265                 270         


Glu Asn Phe Thr Asp Asn Ala Lys Thr Ile Ile Val Gln Leu Lys Glu 
        275                 280                 285             


Ser Val Glu Ile Asn Cys Thr Arg Pro Asn Asn Asn Thr Arg Lys Ser 
    290                 295                 300                 


Ile Thr Ile Gly Pro Gly Arg Ala Phe Tyr Ala Thr Gly Asp Ile Ile 
305                 310                 315                 320 


Gly Asp Ile Arg Gln Ala His Cys Asn Ile Ser Gly Glu Lys Trp Asn 
                325                 330                 335     


Asn Thr Leu Lys Gln Ile Val Thr Lys Leu Gln Ala Gln Phe Gly Asn 
            340                 345                 350         


Lys Thr Ile Val Phe Lys Gln Ser Ser Gly Gly Asp Pro Glu Ile Val 
        355                 360                 365             


Met His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn Ser Thr 
    370                 375                 380                 


Gln Leu Phe Asn Ser Thr Trp Asn Asn Thr Ile Gly Pro Asn Asn Thr 
385                 390                 395                 400 


Asn Gly Thr Ile Thr Leu Pro Cys Arg Ile Lys Gln Ile Ile Asn Arg 
                405                 410                 415     


Trp Gln Glu Val Gly Lys Ala Met Tyr Ala Pro Pro Ile Arg Gly Gln 
            420                 425                 430         


Ile Arg Cys Ser Ser Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly 
        435                 440                 445             


Gly Lys Glu Ile Ser Asn Thr Thr Glu Ile Phe Arg Pro Gly Gly Gly 
    450                 455                 460                 


Asp Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val 
465                 470                 475                 480 


Lys Ile Glu Pro Leu Gly Val Ala Pro Thr Lys Ala Lys Arg Arg Val 
                485                 490                 495     


Val Gln Arg Glu Lys Arg Ala Val Thr Leu Gly Ala Met Phe Leu Gly 
            500                 505                 510         


Phe Leu Gly Ala Ala Gly Ser Thr Met Gly Ala Arg Ser Leu Thr Leu 
        515                 520                 525             


Thr Val Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Asn 
    530                 535                 540                 


Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu Thr 
545                 550                 555                 560 


Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Val Glu Arg 
                565                 570                 575     


Tyr Leu Lys Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys 
            580                 585                 590         


Leu Ile Cys Thr Thr Ala Val Pro Trp Asn Ala Ser Trp Ser Asn Lys 
        595                 600                 605             


Ser Leu Asp Gln Ile Trp Asn Asn Met Thr Trp Met Glu Trp Glu Arg 
    610                 615                 620                 


Glu Ile Asp Asn Tyr Thr Asn Leu Ile Tyr Thr Leu Ile Glu Glu Ser 
625                 630                 635                 640 


Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys 
                645                 650                 655     


Trp Ala Ser Leu Trp Asn Trp Phe Asp Ile Ser Lys Trp Leu Trp Tyr 
            660                 665                 670         


Ile Lys Ile Phe Ile Met Ile Val Gly Gly Leu Val Gly Leu Arg Ile 
        675                 680                 685             


Val Phe Thr Val Leu Ser Ile Val Asn Arg Val Arg Gln Gly Tyr Ser 
    690                 695                 700                 


Pro Leu Ser Phe Gln Thr Arg Phe Pro Ala Pro Arg Gly Pro Asp Arg 
705                 710                 715                 720 


Pro Glu Gly Ile Glu Glu Glu Gly Gly Glu Arg Asp Arg Asp Arg Ser 
                725                 730                 735     


Ser Pro Leu Val His Gly Leu Leu Ala Leu Ile Trp Asp Asp Leu Arg 
            740                 745                 750         


Ser Leu Cys Leu Phe Ser Tyr His Arg Leu Arg Asp Leu Ile Leu Ile 
        755                 760                 765             


Ala Ala Arg Ile Val Glu Leu Leu Gly Arg Arg Gly Trp Glu Ala Leu 
    770                 775                 780                 


Lys Tyr Trp Gly Asn Leu Leu Gln Tyr Trp Ile Gln Glu Leu Lys Asn 
785                 790                 795                 800 


Ser Ala Val Ser Leu Phe Asp Ala Ile Ala Ile Ala Val Ala Glu Gly 
                805                 810                 815     


Thr Asp Arg Ile Ile Glu Val Ala Gln Arg Ile Gly Arg Ala Phe Leu 
            820                 825                 830         


His Ile Pro Arg Arg Ile Arg Gln Gly Phe Glu Arg Ala Leu Leu 
        835                 840                 845         


<210>  2
<211>  1067
<212>  PRT
<213>  RVFV Glycoprotein a.a.

<400>  2

Met Ala Gly Ile Ala Met Thr Val Leu Pro Ala Leu Ala Val Phe Ala 
1               5                   10                  15      


Leu Ala Pro Val Val Phe Ala Glu Asp Pro His Leu Arg Asn Arg Pro 
            20                  25                  30          


Gly Lys Gly His Asn Tyr Ile Asp Gly Met Thr Gln Glu Asp Ala Thr 
        35                  40                  45              


Cys Lys Pro Val Thr Tyr Ala Gly Ala Cys Ser Ser Phe Asp Val Leu 
    50                  55                  60                  


Leu Glu Lys Gly Lys Phe Pro Leu Phe Gln Ser Tyr Ala His His Arg 
65                  70                  75                  80  


Thr Leu Leu Glu Ala Val His Asp Thr Ile Ile Ala Lys Ala Asp Pro 
                85                  90                  95      


Pro Ser Cys Asp Leu Gln Ser Ala His Gly Asn Pro Cys Met Lys Glu 
            100                 105                 110         


Lys Leu Val Met Lys Thr His Cys Pro Asn Asp Tyr Gln Ser Ala His 
        115                 120                 125             


Tyr Leu Asn Asn Asp Gly Lys Met Ala Ser Val Lys Cys Pro Pro Lys 
    130                 135                 140                 


Tyr Gly Leu Thr Glu Asp Cys Asn Phe Cys Arg Gln Met Thr Gly Ala 
145                 150                 155                 160 


Ser Leu Lys Lys Gly Ser Tyr Pro Leu Gln Asp Leu Phe Cys Gln Ser 
                165                 170                 175     


Ser Glu Asp Asp Gly Ser Lys Leu Lys Thr Lys Met Lys Gly Val Cys 
            180                 185                 190         


Glu Val Gly Val Gln Ala His Lys Lys Cys Asp Gly Gln Leu Ser Thr 
        195                 200                 205             


Ala His Glu Val Val Pro Phe Ala Val Phe Lys Asn Ser Lys Lys Val 
    210                 215                 220                 


Tyr Leu Asp Lys Leu Asp Leu Lys Thr Glu Glu Asn Leu Leu Pro Asp 
225                 230                 235                 240 


Ser Phe Val Cys Phe Glu His Lys Gly Gln Tyr Lys Gly Thr Met Asp 
                245                 250                 255     


Ser Gly Gln Thr Lys Arg Glu Leu Lys Ser Phe Asp Ile Ser Gln Cys 
            260                 265                 270         


Pro Lys Ile Gly Gly His Gly Ser Lys Lys Cys Thr Gly Asp Ala Ala 
        275                 280                 285             


Phe Cys Ser Ala Tyr Glu Cys Thr Ala Gln Tyr Ala Asn Ala Tyr Cys 
    290                 295                 300                 


Ser His Ala Asn Gly Ser Gly Ile Val Gln Ile Gln Val Ser Gly Val 
305                 310                 315                 320 


Trp Lys Lys Pro Leu Cys Val Gly Tyr Glu Arg Val Val Val Lys Arg 
                325                 330                 335     


Glu Leu Ser Ala Lys Pro Ile Gln Arg Val Glu Pro Cys Thr Thr Cys 
            340                 345                 350         


Ile Thr Lys Cys Glu Pro His Gly Leu Val Val Arg Ser Thr Gly Phe 
        355                 360                 365             


Lys Ile Ser Ser Ala Val Ala Cys Ala Ser Gly Val Cys Val Thr Gly 
    370                 375                 380                 


Ser Gln Ser Pro Ser Thr Glu Ile Thr Leu Lys Tyr Pro Gly Ile Ser 
385                 390                 395                 400 


Gln Ser Ser Gly Gly Asp Ile Gly Val His Met Ala His Asp Asp Gln 
                405                 410                 415     


Ser Val Ser Ser Lys Ile Val Ala His Cys Pro Pro Gln Asp Pro Cys 
            420                 425                 430         


Leu Val His Gly Cys Ile Val Cys Ala His Gly Leu Ile Asn Tyr Gln 
        435                 440                 445             


Cys His Thr Ala Leu Ser Ala Phe Val Val Val Phe Val Phe Ser Ser 
    450                 455                 460                 


Ile Ala Ile Ile Cys Leu Ala Val Leu Tyr Arg Val Leu Lys Cys Leu 
465                 470                 475                 480 


Lys Ile Ala Pro Arg Lys Val Leu Asn Pro Leu Met Trp Ile Thr Ala 
                485                 490                 495     


Phe Ile Arg Trp Ile Tyr Lys Lys Met Val Ala Arg Val Ala His Asn 
            500                 505                 510         


Ile Asn Gln Val Asn Arg Glu Ile Gly Trp Met Glu Gly Gly Gln Leu 
        515                 520                 525             


Val Leu Gly Asn Pro Ala Pro Ile Pro Arg His Ala Pro Ile Pro Arg 
    530                 535                 540                 


Tyr Ser Thr Tyr Leu Met Leu Leu Leu Ile Val Ser Tyr Ala Ser Ala 
545                 550                 555                 560 


Cys Ser Glu Leu Ile Gln Ala Ser Ser Arg Ile Thr Thr Cys Ser Thr 
                565                 570                 575     


Glu Gly Val Asn Thr Lys Cys Arg Leu Ser Gly Thr Ala Leu Ile Arg 
            580                 585                 590         


Ala Gly Ser Val Gly Ala Glu Ala Cys Leu Met Leu Lys Gly Val Lys 
        595                 600                 605             


Glu Asp Gln Thr Lys Phe Leu Lys Ile Lys Thr Val Ser Ser Glu Leu 
    610                 615                 620                 


Ser Cys Arg Glu Gly Gln Ser Tyr Trp Thr Gly Ser Ile Ser Pro Lys 
625                 630                 635                 640 


Cys Leu Ser Ser Arg Arg Cys His Leu Val Gly Glu Cys His Val Asn 
                645                 650                 655     


Arg Cys Leu Ser Trp Arg Asp Asn Glu Thr Ser Ala Glu Phe Ser Phe 
            660                 665                 670         


Val Gly Glu Ser Thr Thr Met Arg Glu Asn Lys Cys Phe Glu Gln Cys 
        675                 680                 685             


Gly Gly Trp Gly Cys Gly Cys Phe Asn Val Asn Pro Ser Cys Leu Phe 
    690                 695                 700                 


Val His Thr Tyr Leu Gln Ser Val Arg Lys Glu Ala Leu Arg Val Phe 
705                 710                 715                 720 


Asn Cys Ile Asp Trp Val His Lys Leu Thr Leu Glu Ile Thr Asp Phe 
                725                 730                 735     


Asp Gly Ser Val Ser Thr Ile Asp Leu Gly Ala Ser Ser Ser Arg Phe 
            740                 745                 750         


Thr Asn Trp Gly Ser Val Ser Leu Ser Leu Asp Ala Glu Gly Ile Ser 
        755                 760                 765             


Gly Ser Asn Ser Phe Ser Phe Ile Glu Ser Pro Ser Lys Gly Tyr Ala 
    770                 775                 780                 


Ile Val Asp Glu Pro Phe Ser Glu Ile Pro Arg Gln Gly Phe Leu Gly 
785                 790                 795                 800 


Glu Ile Arg Cys Asn Ser Glu Ser Ser Val Leu Ser Ala His Glu Ser 
                805                 810                 815     


Cys Leu Arg Ala Pro Asn Leu Ile Ser Tyr Lys Pro Met Ile Asp Gln 
            820                 825                 830         


Leu Glu Cys Thr Thr Asn Leu Ile Asp Pro Phe Val Val Phe Glu Arg 
        835                 840                 845             


Gly Ser Leu Pro Gln Thr Arg Asn Asp Lys Thr Phe Ala Ala Ser Lys 
    850                 855                 860                 


Gly Asn Arg Gly Val Gln Ala Phe Ser Lys Gly Ser Val Gln Ala Asp 
865                 870                 875                 880 


Leu Thr Leu Met Phe Asp Asn Phe Glu Val Asp Phe Val Gly Ala Ala 
                885                 890                 895     


Val Ser Cys Asp Ala Ala Phe Leu Asn Leu Thr Gly Cys Tyr Ser Cys 
            900                 905                 910         


Asn Ala Gly Ala Arg Val Cys Leu Ser Ile Thr Ser Thr Gly Thr Gly 
        915                 920                 925             


Ser Leu Ser Ala His Asn Lys Asp Gly Ser Leu His Ile Val Leu Pro 
    930                 935                 940                 


Ser Glu Asn Gly Thr Lys Asp Gln Cys Gln Ile Leu His Phe Thr Val 
945                 950                 955                 960 


Pro Glu Val Glu Glu Glu Phe Met Tyr Ser Cys Asp Gly Asp Glu Arg 
                965                 970                 975     


Pro Leu Leu Val Lys Gly Thr Leu Ile Ala Ile Asp Pro Phe Asp Asp 
            980                 985                 990         


Arg Arg Glu Ala Gly Gly Glu Ser  Thr Val Val Asn Pro  Lys Ser Gly 
        995                 1000                 1005             


Ser Trp  Asn Phe Phe Asp Trp  Phe Ser Gly Leu Met  Ser Trp Phe 
    1010                 1015                 1020             


Gly Gly  Pro Leu Lys Thr Ile  Leu Leu Ile Cys Leu  Tyr Val Ala 
    1025                 1030                 1035             


Leu Ser  Ile Gly Leu Phe Phe  Leu Leu Ile Tyr Leu  Gly Arg Thr 
    1040                 1045                 1050             


Gly Leu  Ser Lys Met Trp Leu  Ala Ala Thr Lys Lys  Ala Ser 
    1055                 1060                 1065         


<210>  3
<211>  853
<212>  PRT
<213>  HIV 89.6 Envelope Glycoprotein

<400>  3

Met Arg Val Lys Glu Ile Arg Lys Asn Trp Gln His Leu Arg Gly Gly 
1               5                   10                  15      


Ile Leu Leu Leu Gly Met Leu Met Ile Cys Ser Ala Ala Lys Glu Lys 
            20                  25                  30          


Thr Trp Val Thr Ile Tyr Tyr Gly Val Pro Val Trp Arg Glu Ala Thr 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Thr Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Val Val Leu Gly Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asn Met Val Asp Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Glu Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Thr Asn Leu Asn Ile Thr Lys Asn Thr Thr Asn Pro Thr Ser 
    130                 135                 140                 


Ser Ser Trp Gly Met Met Glu Lys Gly Glu Ile Lys Asn Cys Ser Phe 
145                 150                 155                 160 


Tyr Ile Thr Thr Ser Ile Arg Asn Lys Val Lys Lys Glu Tyr Ala Leu 
                165                 170                 175     


Phe Asn Arg Leu Asp Val Val Pro Ile Glu Asn Thr Asn Asn Thr Lys 
            180                 185                 190         


Tyr Arg Leu Ile Ser Cys Asn Thr Ser Val Ile Thr Gln Ala Cys Pro 
        195                 200                 205             


Lys Val Ser Phe Gln Pro Ile Pro Ile His Tyr Cys Val Pro Ala Gly 
    210                 215                 220                 


Phe Ala Met Leu Lys Cys Asn Asn Lys Thr Phe Asn Gly Ser Gly Pro 
225                 230                 235                 240 


Cys Thr Asn Val Ser Thr Val Gln Cys Thr His Gly Ile Arg Pro Val 
                245                 250                 255     


Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu Asp Ile 
            260                 265                 270         


Val Ile Arg Ser Glu Asn Phe Thr Asp Asn Ala Lys Thr Ile Ile Val 
        275                 280                 285             


Gln Leu Asn Glu Ser Val Val Ile Asn Cys Thr Arg Pro Asn Asn Asn 
    290                 295                 300                 


Thr Arg Arg Arg Leu Ser Ile Gly Pro Gly Arg Ala Phe Tyr Ala Arg 
305                 310                 315                 320 


Arg Asn Ile Ile Gly Asp Ile Arg Gln Ala His Cys Asn Ile Ser Arg 
                325                 330                 335     


Ala Lys Trp Asn Asn Thr Leu Gln Gln Ile Val Ile Lys Leu Arg Glu 
            340                 345                 350         


Lys Phe Arg Asn Lys Thr Ile Ala Phe Asn Gln Ser Ser Gly Gly Asp 
        355                 360                 365             


Pro Glu Ile Val Met His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr 
    370                 375                 380                 


Cys Asn Thr Ala Gln Leu Phe Asn Ser Thr Trp Asn Val Thr Gly Gly 
385                 390                 395                 400 


Thr Asn Gly Thr Glu Gly Asn Asp Ile Ile Thr Leu Gln Cys Arg Ile 
                405                 410                 415     


Lys Gln Ile Ile Asn Met Trp Gln Lys Val Gly Lys Ala Met Tyr Ala 
            420                 425                 430         


Pro Pro Ile Thr Gly Gln Ile Arg Cys Ser Ser Asn Ile Thr Gly Leu 
        435                 440                 445             


Leu Leu Thr Arg Asp Gly Gly Asn Ser Thr Glu Thr Glu Thr Glu Ile 
    450                 455                 460                 


Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Asn Trp Arg Ser Glu Leu 
465                 470                 475                 480 


Tyr Lys Tyr Lys Val Val Arg Ile Glu Pro Ile Gly Val Ala Pro Thr 
                485                 490                 495     


Arg Ala Lys Arg Arg Thr Val Gln Arg Glu Lys Arg Ala Val Gly Ile 
            500                 505                 510         


Gly Ala Val Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly 
        515                 520                 525             


Ala Ala Ser Val Thr Leu Thr Val Gln Ala Arg Leu Leu Leu Ser Gly 
    530                 535                 540                 


Ile Val Gln Gln Gln Asn Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln 
545                 550                 555                 560 


His Met Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg 
                565                 570                 575     


Val Leu Ala Leu Glu Arg Tyr Leu Arg Asp Gln Gln Leu Met Gly Ile 
            580                 585                 590         


Trp Gly Cys Ser Gly Lys Leu Ile Cys Thr Thr Ser Val Pro Trp Asn 
        595                 600                 605             


Val Ser Trp Ser Asn Lys Ser Val Asp Asp Ile Trp Asn Asn Met Thr 
    610                 615                 620                 


Trp Met Glu Trp Glu Arg Glu Ile Asp Asn Tyr Thr Asp Tyr Ile Tyr 
625                 630                 635                 640 


Asp Leu Leu Glu Lys Ser Gln Thr Gln Gln Glu Lys Asn Glu Lys Glu 
                645                 650                 655     


Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe Asp Ile 
            660                 665                 670         


Thr Asn Trp Leu Trp Tyr Ile Arg Leu Phe Ile Met Ile Val Gly Gly 
        675                 680                 685             


Leu Ile Gly Leu Arg Ile Val Phe Ala Val Leu Ser Ile Val Asn Arg 
    690                 695                 700                 


Val Arg Gln Gly Tyr Ser Pro Leu Ser Phe Gln Thr Leu Leu Pro Ala 
705                 710                 715                 720 


Ser Arg Gly Pro Asp Arg Pro Glu Gly Thr Glu Glu Glu Gly Gly Glu 
                725                 730                 735     


Arg Asp Arg Asp Arg Ser Gly Pro Leu Val Asn Gly Phe Leu Ala Leu 
            740                 745                 750         


Phe Trp Val Asp Leu Arg Asn Leu Cys Leu Phe Leu Tyr His Leu Leu 
        755                 760                 765             


Arg Asn Leu Leu Leu Ile Val Thr Arg Ile Val Glu Leu Leu Gly Arg 
    770                 775                 780                 


Arg Gly Trp Glu Ala Leu Lys Tyr Trp Trp Asn Leu Leu Gln Tyr Trp 
785                 790                 795                 800 


Ser Gln Glu Leu Lys Asn Ser Ala Val Ser Leu Leu Asn Ala Thr Ala 
                805                 810                 815     


Ile Ala Val Ala Glu Gly Thr Asp Arg Val Ile Lys Ile Val Gln Arg 
            820                 825                 830         


Ala Cys Arg Ala Ile Arg Asn Ile Pro Thr Arg Ile Arg Gln Gly Leu 
        835                 840                 845             


Glu Arg Ala Leu Leu 
    850             


<210>  4
<211>  507
<212>  PRT
<213>  RVFV GC

<400>  4

Cys Ser Glu Leu Ile Gln Ala Ser Ser Arg Ile Thr Thr Cys Ser Thr 
1               5                   10                  15      


Glu Gly Val Asn Thr Lys Cys Arg Leu Ser Gly Thr Ala Leu Ile Arg 
            20                  25                  30          


Ala Gly Ser Val Gly Ala Glu Ala Cys Leu Met Leu Lys Gly Val Lys 
        35                  40                  45              


Glu Asp Gln Thr Lys Phe Leu Lys Ile Lys Thr Val Ser Ser Glu Leu 
    50                  55                  60                  


Ser Cys Arg Glu Gly Gln Ser Tyr Trp Thr Gly Ser Ile Ser Pro Lys 
65                  70                  75                  80  


Cys Leu Ser Ser Arg Arg Cys His Leu Val Gly Glu Cys His Val Asn 
                85                  90                  95      


Arg Cys Leu Ser Trp Arg Asp Asn Glu Thr Ser Ala Glu Phe Ser Phe 
            100                 105                 110         


Val Gly Glu Ser Thr Thr Met Arg Glu Asn Lys Cys Phe Glu Gln Cys 
        115                 120                 125             


Gly Gly Trp Gly Cys Gly Cys Phe Asn Val Asn Pro Ser Cys Leu Phe 
    130                 135                 140                 


Val His Thr Tyr Leu Gln Ser Val Arg Lys Glu Ala Leu Arg Val Phe 
145                 150                 155                 160 


Asn Cys Ile Asp Trp Val His Lys Leu Thr Leu Glu Ile Thr Asp Phe 
                165                 170                 175     


Asp Gly Ser Val Ser Thr Ile Asp Leu Gly Ala Ser Ser Ser Arg Phe 
            180                 185                 190         


Thr Asn Trp Gly Ser Val Ser Leu Ser Leu Asp Ala Glu Gly Ile Ser 
        195                 200                 205             


Gly Ser Asn Ser Phe Ser Phe Ile Glu Ser Pro Ser Lys Gly Tyr Ala 
    210                 215                 220                 


Ile Val Asp Glu Pro Phe Ser Glu Ile Pro Arg Gln Gly Phe Leu Gly 
225                 230                 235                 240 


Glu Ile Arg Cys Asn Ser Glu Ser Ser Val Leu Ser Ala His Glu Ser 
                245                 250                 255     


Cys Leu Arg Ala Pro Asn Leu Ile Ser Tyr Lys Pro Met Ile Asp Gln 
            260                 265                 270         


Leu Glu Cys Thr Thr Asn Leu Ile Asp Pro Phe Val Val Phe Glu Arg 
        275                 280                 285             


Gly Ser Leu Pro Gln Thr Arg Asn Asp Lys Thr Phe Ala Ala Ser Lys 
    290                 295                 300                 


Gly Asn Arg Gly Val Gln Ala Phe Ser Lys Gly Ser Val Gln Ala Asp 
305                 310                 315                 320 


Leu Thr Leu Met Phe Asp Asn Phe Glu Val Asp Phe Val Gly Ala Ala 
                325                 330                 335     


Val Ser Cys Asp Ala Ala Phe Leu Asn Leu Thr Gly Cys Tyr Ser Cys 
            340                 345                 350         


Asn Ala Gly Ala Arg Val Cys Leu Ser Ile Thr Ser Thr Gly Thr Gly 
        355                 360                 365             


Ser Leu Ser Ala His Asn Lys Asp Gly Ser Leu His Ile Val Leu Pro 
    370                 375                 380                 


Ser Glu Asn Gly Thr Lys Asp Gln Cys Gln Ile Leu His Phe Thr Val 
385                 390                 395                 400 


Pro Glu Val Glu Glu Glu Phe Met Tyr Ser Cys Asp Gly Asp Glu Arg 
                405                 410                 415     


Pro Leu Leu Val Lys Gly Thr Leu Ile Ala Ile Asp Pro Phe Asp Asp 
            420                 425                 430         


Arg Arg Glu Ala Gly Gly Glu Ser Thr Val Val Asn Pro Lys Ser Gly 
        435                 440                 445             


Ser Trp Asn Phe Phe Asp Trp Phe Ser Gly Leu Met Ser Trp Phe Gly 
    450                 455                 460                 


Gly Pro Leu Lys Thr Ile Leu Leu Ile Cys Leu Tyr Val Ala Leu Ser 
465                 470                 475                 480 


Ile Gly Leu Phe Phe Leu Leu Ile Tyr Leu Gly Arg Thr Gly Leu Ser 
                485                 490                 495     


Lys Met Trp Leu Ala Ala Thr Lys Lys Ala Ser 
            500                 505         


<210>  5
<211>  527
<212>  PRT
<213>  RVFV GN

<400>  5

Glu Asp Pro His Leu Arg Asn Arg Pro Gly Lys Gly His Asn Tyr Ile 
1               5                   10                  15      


Asp Gly Met Thr Gln Glu Asp Ala Thr Cys Lys Pro Val Thr Tyr Ala 
            20                  25                  30          


Gly Ala Cys Ser Ser Phe Asp Val Leu Leu Glu Lys Gly Lys Phe Pro 
        35                  40                  45              


Leu Phe Gln Ser Tyr Ala His His Arg Thr Leu Leu Glu Ala Val His 
    50                  55                  60                  


Asp Thr Ile Ile Ala Lys Ala Asp Pro Pro Ser Cys Asp Leu Gln Ser 
65                  70                  75                  80  


Ala His Gly Asn Pro Cys Met Lys Glu Lys Leu Val Met Lys Thr His 
                85                  90                  95      


Cys Pro Asn Asp Tyr Gln Ser Ala His Tyr Leu Asn Asn Asp Gly Lys 
            100                 105                 110         


Met Ala Ser Val Lys Cys Pro Pro Lys Tyr Gly Leu Thr Glu Asp Cys 
        115                 120                 125             


Asn Phe Cys Arg Gln Met Thr Gly Ala Ser Leu Lys Lys Gly Ser Tyr 
    130                 135                 140                 


Pro Leu Gln Asp Leu Phe Cys Gln Ser Ser Glu Asp Asp Gly Ser Lys 
145                 150                 155                 160 


Leu Lys Thr Lys Met Lys Gly Val Cys Glu Val Gly Val Gln Ala His 
                165                 170                 175     


Lys Lys Cys Asp Gly Gln Leu Ser Thr Ala His Glu Val Val Pro Phe 
            180                 185                 190         


Ala Val Phe Lys Asn Ser Lys Lys Val Tyr Leu Asp Lys Leu Asp Leu 
        195                 200                 205             


Lys Thr Glu Glu Asn Leu Leu Pro Asp Ser Phe Val Cys Phe Glu His 
    210                 215                 220                 


Lys Gly Gln Tyr Lys Gly Thr Met Asp Ser Gly Gln Thr Lys Arg Glu 
225                 230                 235                 240 


Leu Lys Ser Phe Asp Ile Ser Gln Cys Pro Lys Ile Gly Gly His Gly 
                245                 250                 255     


Ser Lys Lys Cys Thr Gly Asp Ala Ala Phe Cys Ser Ala Tyr Glu Cys 
            260                 265                 270         


Thr Ala Gln Tyr Ala Asn Ala Tyr Cys Ser His Ala Asn Gly Ser Gly 
        275                 280                 285             


Ile Val Gln Ile Gln Val Ser Gly Val Trp Lys Lys Pro Leu Cys Val 
    290                 295                 300                 


Gly Tyr Glu Arg Val Val Val Lys Arg Glu Leu Ser Ala Lys Pro Ile 
305                 310                 315                 320 


Gln Arg Val Glu Pro Cys Thr Thr Cys Ile Thr Lys Cys Glu Pro His 
                325                 330                 335     


Gly Leu Val Val Arg Ser Thr Gly Phe Lys Ile Ser Ser Ala Val Ala 
            340                 345                 350         


Cys Ala Ser Gly Val Cys Val Thr Gly Ser Gln Ser Pro Ser Thr Glu 
        355                 360                 365             


Ile Thr Leu Lys Tyr Pro Gly Ile Ser Gln Ser Ser Gly Gly Asp Ile 
    370                 375                 380                 


Gly Val His Met Ala His Asp Asp Gln Ser Val Ser Ser Lys Ile Val 
385                 390                 395                 400 


Ala His Cys Pro Pro Gln Asp Pro Cys Leu Val His Gly Cys Ile Val 
                405                 410                 415     


Cys Ala His Gly Leu Ile Asn Tyr Gln Cys His Thr Ala Leu Ser Ala 
            420                 425                 430         


Phe Val Val Val Phe Val Phe Ser Ser Ile Ala Ile Ile Cys Leu Ala 
        435                 440                 445             


Val Leu Tyr Arg Val Leu Lys Cys Leu Lys Ile Ala Pro Arg Lys Val 
    450                 455                 460                 


Leu Asn Pro Leu Met Trp Ile Thr Ala Phe Ile Arg Trp Ile Tyr Lys 
465                 470                 475                 480 


Lys Met Val Ala Arg Val Ala His Asn Ile Asn Gln Val Asn Arg Glu 
                485                 490                 495     


Ile Gly Trp Met Glu Gly Gly Gln Leu Val Leu Gly Asn Pro Ala Pro 
            500                 505                 510         


Ile Pro Arg His Ala Pro Ile Pro Arg Tyr Ser Thr Tyr Leu Met 
        515                 520                 525         


<210>  6
<211>  26
<212>  PRT
<213>  N-terminus of the SIV Env Glyocoprotein-41 TM domain

<400>  6

Tyr Ile Gln Tyr Gly Val Tyr Ile Val Val Gly Val Ile Leu Leu Arg 
1               5                   10                  15      


Ile Val Ile Tyr Ile Val Gln Met Leu Ala 
            20                  25      


<210>  7
<211>  232
<212>  PRT
<213>  extracellular coding domain of the FL gene

<400>  7

Met Thr Val Leu Ala Pro Ala Trp Ser Pro Asn Ser Ser Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Ser Pro Cys Leu Arg Gly Thr Pro Asp Cys Tyr 
            20                  25                  30          


Phe Ser His Ser Pro Ile Ser Ser Asn Phe Lys Val Lys Phe Arg Glu 
        35                  40                  45              


Leu Thr Asp His Leu Leu Lys Asp Tyr Pro Val Thr Val Ala Val Asn 
    50                  55                  60                  


Leu Gln Asp Glu Lys His Cys Lys Ala Leu Trp Ser Leu Phe Leu Ala 
65                  70                  75                  80  


Gln Arg Trp Ile Glu Gln Leu Lys Thr Val Ala Gly Ser Lys Met Gln 
                85                  90                  95      


Thr Leu Leu Glu Asp Val Asn Thr Glu Ile His Phe Val Thr Ser Cys 
            100                 105                 110         


Thr Phe Gln Pro Leu Pro Glu Cys Leu Arg Phe Val Gln Thr Asn Ile 
        115                 120                 125             


Ser His Leu Leu Lys Asp Thr Cys Thr Gln Leu Leu Ala Leu Lys Pro 
    130                 135                 140                 


Cys Ile Gly Lys Ala Cys Gln Asn Phe Ser Arg Cys Leu Glu Val Gln 
145                 150                 155                 160 


Cys Gln Pro Asp Ser Ser Thr Leu Leu Pro Pro Arg Ser Pro Ile Ala 
                165                 170                 175     


Leu Glu Ala Thr Glu Leu Pro Glu Pro Arg Pro Arg Gln Leu Leu Leu 
            180                 185                 190         


Leu Leu Leu Leu Leu Leu Pro Leu Thr Leu Val Leu Leu Ala Ala Ala 
        195                 200                 205             


Trp Gly Leu Arg Trp Gln Arg Ala Arg Arg Arg Gly Glu Leu His Pro 
    210                 215                 220                 


Gly Val Pro Leu Pro Ser His Pro 
225                 230         


<210>  8
<211>  164
<212>  PRT
<213>  SIV mac239 Env cytoplasmic domain

<400>  8

Lys Leu Arg Gln Gly Tyr Arg Pro Val Phe Ser Ser Pro Pro Ser Tyr 
1               5                   10                  15      


Phe Gln Gln Thr His Ile Gln Gln Asp Pro Ala Leu Pro Thr Arg Glu 
            20                  25                  30          


Gly Lys Glu Arg Asp Gly Gly Glu Gly Gly Gly Asn Ser Ser Trp Pro 
        35                  40                  45              


Trp Gln Ile Glu Tyr Ile His Phe Leu Ile Arg Gln Leu Ile Arg Leu 
    50                  55                  60                  


Leu Thr Trp Leu Phe Ser Asn Cys Arg Thr Leu Leu Ser Arg Val Tyr 
65                  70                  75                  80  


Gln Ile Leu Gln Pro Ile Leu Gln Arg Leu Ser Ala Thr Leu Gln Arg 
                85                  90                  95      


Ile Arg Glu Val Leu Arg Thr Glu Leu Thr Tyr Leu Gln Tyr Gly Trp 
            100                 105                 110         


Ser Tyr Phe His Glu Ala Val Gln Ala Val Trp Arg Ser Ala Thr Glu 
        115                 120                 125             


Thr Leu Ala Gly Ala Trp Gly Asp Leu Trp Glu Thr Leu Arg Arg Gly 
    130                 135                 140                 


Gly Arg Trp Ile Leu Ala Ile Pro Arg Arg Ile Arg Gln Gly Leu Glu 
145                 150                 155                 160 


Leu Thr Leu Leu 
                


<210>  9
<211>  23
<212>  PRT
<213>  tPA signal peptide

<400>  9

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Ala Arg 
            20              


<210>  10
<211>  40
<212>  PRT
<213>  GPI-anchoring seq. access no. x52645

<400>  10

Leu Ala Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln Val 
1               5                   10                  15      


Ser Phe Cys Leu Val Met Val Leu Leu Phe Ala Val Asp Thr Gly Leu 
            20                  25                  30          


Tyr Phe Ser Val Lys Thr Asn Ile 
        35                  40  


<210>  11
<211>  300
<212>  PRT
<213>  C3d sequence

<400>  11

Thr Val Ile Ala Val His Tyr Leu Asp Gln Thr Glu Gln Trp Glu Lys 
1               5                   10                  15      


Phe Gly Ile Glu Lys Arg Gln Glu Ala Leu Glu Leu Ile Lys Lys Gly 
            20                  25                  30          


Tyr Thr Gln Gln Leu Ala Phe Lys Gln Pro Ser Ser Ala Tyr Ala Ala 
        35                  40                  45              


Phe Asn Asn Arg Pro Pro Ser Thr Trp Leu Thr Ala Tyr Val Val Lys 
    50                  55                  60                  


Val Phe Ser Leu Ala Ala Asn Leu Ile Ala Ile Asp Ser His Val Leu 
65                  70                  75                  80  


Cys Gly Ala Val Lys Trp Leu Ile Leu Glu Lys Gln Lys Pro Asp Gly 
                85                  90                  95      


Val Phe Gln Glu Asp Gly Pro Val Ile His Gln Glu Met Ile Gly Gly 
            100                 105                 110         


Phe Arg Asn Ala Lys Glu Ala Asp Val Ser Leu Thr Ala Phe Val Leu 
        115                 120                 125             


Ile Ala Leu Gln Glu Ala Arg Asp Ile Cys Glu Gly Gln Val Asn Ser 
    130                 135                 140                 


Leu Pro Gly Ser Ile Asn Lys Ala Gly Glu Tyr Ile Glu Ala Ser Tyr 
145                 150                 155                 160 


Met Asn Leu Gln Arg Pro Tyr Thr Val Ala Ile Ala Gly Tyr Ala Leu 
                165                 170                 175     


Ala Leu Met Asn Lys Leu Glu Glu Pro Tyr Leu Gly Lys Phe Leu Asn 
            180                 185                 190         


Thr Ala Lys Asp Arg Asn Arg Trp Glu Glu Pro Asp Gln Gln Leu Tyr 
        195                 200                 205             


Asn Val Glu Ala Thr Ser Tyr Ala Leu Leu Ala Leu Leu Leu Leu Lys 
    210                 215                 220                 


Asp Phe Asp Ser Val Pro Pro Val Val Arg Trp Leu Asn Glu Gln Arg 
225                 230                 235                 240 


Tyr Tyr Gly Gly Gly Tyr Gly Ser Thr Gln Ala Thr Phe Met Val Phe 
                245                 250                 255     


Gln Ala Leu Ala Gln Tyr Gln Thr Asp Val Pro Asp His Lys Asp Leu 
            260                 265                 270         


Asn Met Asp Val Ser Phe His Leu Pro Ser Arg Ser Ser Ala Thr Thr 
        275                 280                 285             


Phe Arg Leu Leu Trp Glu Asn Gly Asn Leu Leu Arg 
    290                 295                 300 


