                               SEQUENCE LISTING                               

<110> F. Hoffmann-La Roche AG

<120> Novel analogs of vasoactive intestinal peptides

<130> 23410

<140>
<141>

<160> 25                            

<170> PatentIn Ver. 3.3

<210> 1
<211> 28
<212> PRT
<213> Homo sapiens

<400> 1
His Ser Asp Ala Val Phe Thr Asp Asn Tyr Thr Arg Leu Arg Lys Gln  
  1               5                  10                  15    

Met Ala Val Lys Lys Tyr Leu Asn Ser Ile Leu Asn                  
             20                  25            


<210> 2
<211> 31
<212> PRT
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      analogue of vasoactive intestinal peptide

<220> 
<221> MOD_RES
<222> (2)
<223> Ser or Ala

<220> 
<221> MOD_RES
<222> (5)
<223> Thr, Ser, Asp, Gln, Pro, or
      C-alpha-Methyl-L-Valine

<220> 
<221> MOD_RES
<222> (16)
<223> Gln, Ala, or Arg

<220> 
<221> MOD_RES
<222> (17)
<223> Nle

<220> 
<221> MOD_RES
<222> (18)
<223> Ala, Lys, or Glu

<220> 
<221> MOD_RES
<222> (27)
<223> Lys or Leu, and must be Lys when position 5 is
      C-alpha-Methyl-L-Valine and position 16 is Arg

<220> 
<221> MOD_RES
<222> (28)
<223> Lys or Asn

<220> 
<223> Residues 21 and 25 are connected by a side-chain
      to side-chain covalent linkage

<400> 2
His Xaa Asp Ala Xaa Phe Thr Glu Asn Tyr Thr Lys Leu Arg Lys Xaa  
  1               5                  10                  15    

Xaa Xaa Ala Lys Lys Tyr Leu Asn Asp Leu Xaa Xaa Gly Gly Thr      
             20                  25                  30    


<210> 3
<211> 31
<212> PRT
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      analogue of vasoactive intestinal peptide

<220> 
<221> MOD_RES
<222> (17)
<223> Nle

<220> 
<223> Residues 21 and 25 are connected by a side-chain
      to side-chain covalent linkage

<400> 3
His Ser Asp Ala Thr Phe Thr Glu Asn Tyr Thr Lys Leu Arg Lys Gln  
  1               5                  10                  15    

Xaa Ala Ala Lys Lys Tyr Leu Asn Asp Leu Lys Lys Gly Gly Thr      
             20                  25                  30    


<210> 4
<211> 31
<212> PRT
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      analogue of vasoactive intestinal peptide

<220> 
<221> MOD_RES
<222> (17)
<223> Nle

<220> 
<223> Residues 21 and 25 are connected by a side-chain
      to side-chain covalent linkage

<400> 4
His Ser Asp Ala Ser Phe Thr Glu Asn Tyr Thr Lys Leu Arg Lys Gln  
  1               5                  10                  15    

Xaa Ala Ala Lys Lys Tyr Leu Asn Asp Leu Lys Lys Gly Gly Thr      
             20                  25                  30    


<210> 5
<211> 31
<212> PRT
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      analogue of vasoactive intestinal peptide

<220> 
<221> MOD_RES
<222> (17)
<223> Nle

<220> 
<223> Residues 21 and 25 are connected by a side-chain
      to side-chain covalent linkage

<400> 5
His Ser Asp Ala Asp Phe Thr Glu Asn Tyr Thr Lys Leu Arg Lys Gln  
  1               5                  10                  15    

Xaa Ala Ala Lys Lys Tyr Leu Asn Asp Leu Lys Lys Gly Gly Thr      
             20                  25                  30    


<210> 6
<211> 31
<212> PRT
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      analogue of vasoactive intestinal peptide

<220> 
<221> MOD_RES
<222> (17)
<223> Nle

<220> 
<223> Residues 21 and 25 are connected by a side-chain
      to side-chain covalent linkage

<400> 6
His Ser Asp Ala Gln Phe Thr Glu Asn Tyr Thr Lys Leu Arg Lys Gln  
  1               5                  10                  15    

Xaa Ala Ala Lys Lys Tyr Leu Asn Asp Leu Lys Lys Gly Gly Thr      
             20                  25                  30    


<210> 7
<211> 31
<212> PRT
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      analogue of vasoactive intestinal peptide

<220> 
<221> MOD_RES
<222> (17)
<223> Nle

<220> 
<223> Residues 21 and 25 are connected by a side-chain
      to side-chain covalent linkage

<400> 7
His Ser Asp Ala Pro Phe Thr Glu Asn Tyr Thr Lys Leu Arg Lys Gln  
  1               5                  10                  15    

Xaa Ala Ala Lys Lys Tyr Leu Asn Asp Leu Lys Lys Gly Gly Thr      
             20                  25                  30    


<210> 8
<211> 31
<212> PRT
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      analogue of vasoactive intestinal peptide

<220> 
<221> MOD_RES
<222> (5)
<223> C-alpha-Methyl-L-Valine 

<220> 
<221> MOD_RES
<222> (17)
<223> Nle

<220> 
<223> Residues 21 and 25 are connected by a side-chain
      to side-chain covalent linkage

<400> 8
His Ser Asp Ala Xaa Phe Thr Glu Asn Tyr Thr Lys Leu Arg Lys Gln  
  1               5                  10                  15    

Xaa Ala Ala Lys Lys Tyr Leu Asn Asp Leu Lys Lys Gly Gly Thr      
             20                  25                  30    


<210> 9
<211> 31
<212> PRT
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      analogue of vasoactive intestinal peptide

<220> 
<221> MOD_RES
<222> (17)
<223> Nle

<220> 
<223> Residues 21 and 25 are connected by a side-chain
      to side-chain covalent linkage

<400> 9
His Ser Asp Ala Ser Phe Thr Glu Asn Tyr Thr Lys Leu Arg Lys Gln  
  1               5                  10                  15    

Xaa Glu Ala Lys Lys Tyr Leu Asn Asp Leu Lys Lys Gly Gly Thr      
             20                  25                  30    


<210> 10
<211> 31
<212> PRT
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      analogue of vasoactive intestinal peptide

<220> 
<221> MOD_RES
<222> (17)
<223> Nle

<220> 
<223> Residues 21 and 25 are connected by a side-chain
      to side-chain covalent linkage

<400> 10
His Ser Asp Ala Ser Phe Thr Glu Asn Tyr Thr Lys Leu Arg Lys Gln  
  1               5                  10                  15    

Xaa Ala Ala Lys Lys Tyr Leu Asn Asp Leu Lys Lys Gly Gly Thr      
             20                  25                  30    


<210> 11
<211> 31
<212> PRT
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      analogue of vasoactive intestinal peptide

<220> 
<221> MOD_RES
<222> (17)
<223> Nle

<220> 
<223> Residues 21 and 25 are connected by a side-chain
      to side-chain covalent linkage

<400> 11
His Ser Asp Ala Ser Phe Thr Glu Asn Tyr Thr Lys Leu Arg Lys Gln  
  1               5                  10                  15    

Xaa Lys Ala Lys Lys Tyr Leu Asn Asp Leu Lys Lys Gly Gly Thr      
             20                  25                  30    


<210> 12
<211> 31
<212> PRT
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      analogue of vasoactive intestinal peptide

<220> 
<221> MOD_RES
<222> (17)
<223> Nle

<220> 
<223> Residues 21 and 25 are connected by a side-chain
      to side-chain covalent linkage

<400> 12
His Ser Asp Ala Ser Phe Thr Glu Asn Tyr Thr Lys Leu Arg Lys Ala  
  1               5                  10                  15    

Xaa Glu Ala Lys Lys Tyr Leu Asn Asp Leu Lys Lys Gly Gly Thr      
             20                  25                  30    


<210> 13
<211> 31
<212> PRT
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      analogue of vasoactive intestinal peptide

<220> 
<221> MOD_RES
<222> (17)
<223> Nle

<220> 
<223> Residues 21 and 25 are connected by a side-chain
      to side-chain covalent linkage

<400> 13
His Ser Asp Ala Ser Phe Thr Glu Asn Tyr Thr Lys Leu Arg Lys Gln  
  1               5                  10                  15    

Xaa Ala Ala Lys Lys Tyr Leu Asn Asp Leu Leu Asn Gly Gly Thr      
             20                  25                  30    


<210> 14
<211> 31
<212> PRT
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      analogue of vasoactive intestinal peptide

<220> 
<221> MOD_RES
<222> (17)
<223> Nle

<220> 
<223> Residues 21 and 25 are connected by a side-chain
      to side-chain covalent linkage

<400> 14
His Ala Asp Ala Ser Phe Thr Glu Asn Tyr Thr Lys Leu Arg Lys Gln  
  1               5                  10                  15    

Xaa Ala Ala Lys Lys Tyr Leu Asn Asp Leu Lys Lys Gly Gly Thr      
             20                  25                  30    


<210> 15
<211> 31
<212> PRT
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      analogue of vasoactive intestinal peptide

<220> 
<221> MOD_RES
<222> (17)
<223> Nle

<220> 
<223> Residues 21 and 25 are connected by a side-chain
      to side-chain covalent linkage

<400> 15
His Ser Asp Ala Ser Phe Thr Glu Asn Tyr Thr Lys Leu Arg Lys Arg  
  1               5                  10                  15    

Xaa Ala Ala Lys Lys Tyr Leu Asn Asp Leu Lys Lys Gly Gly Thr      
             20                  25                  30    


<210> 16
<211> 31
<212> PRT
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      analogue of vasoactive intestinal peptide

<220> 
<221> MOD_RES
<222> (17)
<223> Nle

<220> 
<223> Residues 21 and 25 are connected by a side-chain
      to side-chain covalent linkage

<400> 16
His Ser Asp Ala Ser Phe Thr Glu Asn Tyr Thr Lys Leu Arg Lys Arg  
  1               5                  10                  15    

Xaa Ala Ala Lys Lys Tyr Leu Asn Asp Leu Leu Asn Gly Gly Thr      
             20                  25                  30    


<210> 17
<211> 31
<212> PRT
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      analogue of vasoactive intestinal peptide

<220> 
<221> MOD_RES
<222> (17)
<223> Nle

<220> 
<223> Residues 21 and 25 are connected by a side-chain
      to side-chain covalent linkage

<400> 17
His Ser Asp Ala Ser Phe Thr Glu Asn Tyr Thr Lys Leu Arg Lys Arg  
  1               5                  10                  15    

Xaa Glu Ala Lys Lys Tyr Leu Asn Asp Leu Lys Lys Gly Gly Thr      
             20                  25                  30    


<210> 18
<211> 31
<212> PRT
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      analogue of vasoactive intestinal peptide

<220> 
<221> MOD_RES
<222> (17)
<223> Nle

<220> 
<223> Residues 21 and 25 are connected by a side-chain
      to side-chain covalent linkage

<400> 18
His Ser Asp Ala Ser Phe Thr Glu Asn Tyr Thr Lys Leu Arg Lys Arg  
  1               5                  10                  15    

Xaa Lys Ala Lys Lys Tyr Leu Asn Asp Leu Lys Lys Gly Gly Thr      
             20                  25                  30    


<210> 19
<211> 31
<212> PRT
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      analogue of vasoactive intestinal peptide

<220> 
<221> MOD_RES
<222> (17)
<223> Nle

<220> 
<223> Residues 21 and 25 are connected by a side-chain
      to side-chain covalent linkage

<400> 19
His Ala Asp Ala Ser Phe Thr Glu Asn Tyr Thr Lys Leu Arg Lys Arg  
  1               5                  10                  15    

Xaa Glu Ala Lys Lys Tyr Leu Asn Asp Leu Lys Lys Gly Gly Thr      
             20                  25                  30    


<210> 20
<211> 31
<212> PRT
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      analogue of vasoactive intestinal peptide

<220> 
<221> MOD_RES
<222> (17)
<223> Nle

<220> 
<223> Residues 21 and 25 are connected by a side-chain
      to side-chain covalent linkage

<400> 20
His Ala Asp Ala Ser Phe Thr Glu Asn Tyr Thr Lys Leu Arg Lys Arg  
  1               5                  10                  15    

Xaa Lys Ala Lys Lys Tyr Leu Asn Asp Leu Lys Lys Gly Gly Thr      
             20                  25                  30    


<210> 21
<211> 31
<212> PRT
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      analogue of vasoactive intestinal peptide

<220> 
<221> MOD_RES
<222> (17)
<223> Nle

<220> 
<223> Residues 21 and 25 are connected by a side-chain
      to side-chain covalent linkage

<400> 21
His Ser Asp Ala Ser Phe Thr Glu Asn Tyr Thr Lys Leu Arg Lys Arg  
  1               5                  10                  15    

Xaa Glu Ala Lys Lys Tyr Leu Asn Asp Leu Leu Lys Gly Gly Thr      
             20                  25                  30    


<210> 22
<211> 31
<212> PRT
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      analogue of vasoactive intestinal peptide

<220> 
<221> MOD_RES
<222> (5)
<223> C-alpha-Methyl-L-Valine 

<220> 
<221> MOD_RES
<222> (17)
<223> Nle

<220> 
<223> Residues 21 and 25 are connected by a side-chain
      to side-chain covalent linkage

<400> 22
His Ser Asp Ala Xaa Phe Thr Glu Asn Tyr Thr Lys Leu Arg Lys Gln  
  1               5                  10                  15    

Xaa Ala Ala Lys Lys Tyr Leu Asn Asp Leu Leu Lys Gly Gly Thr      
             20                  25                  30    


<210> 23
<211> 31
<212> PRT
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      analogue of vasoactive intestinal peptide

<220> 
<221> MOD_RES
<222> (5)
<223> C-alpha-Methyl-L-Valine 

<220> 
<221> MOD_RES
<222> (17)
<223> Nle

<220> 
<223> Residues 21 and 25 are connected by a side-chain
      to side-chain covalent linkage

<400> 23
His Ala Asp Ala Xaa Phe Thr Glu Asn Tyr Thr Lys Leu Arg Lys Gln  
  1               5                  10                  15    

Xaa Ala Ala Lys Lys Tyr Leu Asn Asp Leu Lys Lys Gly Gly Thr      
             20                  25                  30    


<210> 24
<211> 31
<212> PRT
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      analogue of vasoactive intestinal peptide

<220> 
<221> MOD_RES
<222> (5)
<223> C-alpha-Methyl-L-Valine 

<220> 
<221> MOD_RES
<222> (17)
<223> Nle

<220> 
<223> Residues 21 and 25 are connected by a side-chain
      to side-chain covalent linkage

<400> 24
His Ser Asp Ala Xaa Phe Thr Glu Asn Tyr Thr Lys Leu Arg Lys Arg  
  1               5                  10                  15    

Xaa Ala Ala Lys Lys Tyr Leu Asn Asp Leu Lys Lys Gly Gly Thr      
             20                  25                  30    


<210> 25
<211> 31
<212> PRT
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      analogue of vasoactive intestinal peptide

<220> 
<221> MOD_RES
<222> (5)
<223> C-alpha-Methyl-L-Valine 

<220> 
<221> MOD_RES
<222> (17)
<223> Nle

<220> 
<223> Residues 21 and 25 are connected by a side-chain
      to side-chain covalent linkage

<400> 25
His Ala Asp Ala Xaa Phe Thr Glu Asn Tyr Thr Lys Leu Arg Lys Gln  
  1               5                  10                  15    

Xaa Ala Ala Lys Lys Tyr Leu Asn Asp Leu Leu Lys Gly Gly Thr      
             20                  25                  30    


