                         SEQUENCE LISTING

<110>  F. Hoffmann-La Roche AG
       Roberts, Christopher  R.
 
<120>  INSULINOTROPIC  PEPTIDE SYNTHESIS USING SOLID AND SOLUTION PHASE 
       COMBINATION TECHNIQUES

<130>  Case 23831

<150>  US 60/815,919
<151>  2006-06-23

<160>  13    

<170>  PatentIn version 3.4

<210>  1
<211>  37
<212>  PRT
<213>  Homo sapiens

<400>  1

His Asp Glu Phe Glu Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val 
1               5                   10                  15      


Ser Ser Tyr Leu Glu Gly Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu 
            20                  25                  30          


Val Lys Gly Arg Gly 
        35          


<210>  2
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  2

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly 
            20                  25                  30      


<210>  3
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  3

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg 
            20                  25                  30  


<210>  4
<211>  30
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chemically synthesized peptide fragment


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa is Aib

<400>  4

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Xaa Arg 
            20                  25                  30  


<210>  5
<211>  30
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chemically synthesized peptide fragment


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is an achiral amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is an achiral amino acid

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa is an achiral amino acid

<400>  5

His Xaa Glu Xaa Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Xaa Arg 
            20                  25                  30  


<210>  6
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chemically synthesized peptide fragment


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is an achiral amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is an achiral amino acid

<400>  6

His Xaa Glu Xaa 
1               


<210>  7
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chemically synthesized peptide fragment


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Aib

<400>  7

His Xaa Glu Gly 
1               


<210>  8
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chemically synthesized peptide fragment


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is an amino acid of a pseudoproline dipeptide (residues 7-8)

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is an amino acid of a pseudoproline dipeptide (residues 7-8)

<400>  8

Thr Phe Thr Ser Asp Val Xaa Xaa Tyr Leu Glu Gly 
1               5                   10          


<210>  9
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chemically synthesized peptide fragment


<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa is an achiral amino acid

<400>  9

Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Xaa 
1               5                   10              


<210>  10
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chemically synthesized peptide fragment


<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa is Aib

<400>  10

Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Xaa 
1               5                   10              


<210>  11
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chemically synthesized peptide fragment


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is an achiral amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is an achiral amino acid

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is an amino acid of a pseudoproline dipeptide (residues 
       11-12)

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is an amino acid of a pseudoproline dipeptide (residues 
       11-12)

<400>  11

His Xaa Glu Xaa Thr Phe Thr Ser Asp Val Xaa Xaa Tyr Leu Glu Gly 
1               5                   10                  15      


<210>  12
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chemically synthesized peptide fragment


<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa is an achiral amino acid

<400>  12

Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Xaa Arg 
1               5                   10                  


<210>  13
<211>  30
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chemically synthesized peptide fragment


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is an achiral amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is an achiral amino acid

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is an amino acid of a pseudoproline dipeptide (residues 
       11-12)

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is an amino acid of a pseudoproline dipeptide (residues 
       11-12)

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa is an achiral amino acid

<400>  13

His Xaa Glu Xaa Thr Phe Thr Ser Asp Val Xaa Xaa Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Xaa Arg 
            20                  25                  30  


