                              Sequence Listing

<110> Genentech, Inc.
      Chant, John
      Guerrero, Anthony S.
      Haverty, Peter
      Honchell, Cynthia
      Jung, Kenneth
      Wu, Thomas

<120> METHODS AND COMPOSITIONS FOR THE DIAGNOSIS AND 
      TREATMENT OF CANCER

<130> P2364R1 WO


<150> US 60/799,772
<151> 2006-05-12

<160> 2

<210> 1
<211> 821
<212> PRT
<213> Homo sapiens

<400> 1
 Met Val Ser Trp Gly Arg Phe Ile Cys Leu Val Val Val Thr Met
   1               5                  10                  15

 Ala Thr Leu Ser Leu Ala Arg Pro Ser Phe Ser Leu Val Glu Asp
                  20                  25                  30

 Thr Thr Leu Glu Pro Glu Glu Pro Pro Thr Lys Tyr Gln Ile Ser
                  35                  40                  45

 Gln Pro Glu Val Tyr Val Ala Ala Pro Gly Glu Ser Leu Glu Val
                  50                  55                  60

 Arg Cys Leu Leu Lys Asp Ala Ala Val Ile Ser Trp Thr Lys Asp
                  65                  70                  75

 Gly Val His Leu Gly Pro Asn Asn Arg Thr Val Leu Ile Gly Glu
                  80                  85                  90

 Tyr Leu Gln Ile Lys Gly Ala Thr Pro Arg Asp Ser Gly Leu Tyr
                  95                 100                 105

 Ala Cys Thr Ala Ser Arg Thr Val Asp Ser Glu Thr Trp Tyr Phe
                 110                 115                 120

 Met Val Asn Val Thr Asp Ala Ile Ser Ser Gly Asp Asp Glu Asp
                 125                 130                 135

 Asp Thr Asp Gly Ala Glu Asp Phe Val Ser Glu Asn Ser Asn Asn
                 140                 145                 150

 Lys Arg Ala Pro Tyr Trp Thr Asn Thr Glu Lys Met Glu Lys Arg
                 155                 160                 165

 Leu His Ala Val Pro Ala Ala Asn Thr Val Lys Phe Arg Cys Pro
                 170                 175                 180

 Ala Gly Gly Asn Pro Met Pro Thr Met Arg Trp Leu Lys Asn Gly
                 185                 190                 195

 Lys Glu Phe Lys Gln Glu His Arg Ile Gly Gly Tyr Lys Val Arg
                 200                 205                 210

 Asn Gln His Trp Ser Leu Ile Met Glu Ser Val Val Pro Ser Asp
                 215                 220                 225

 Lys Gly Asn Tyr Thr Cys Val Val Glu Asn Glu Tyr Gly Ser Ile
                 230                 235                 240

 Asn His Thr Tyr His Leu Asp Val Val Glu Arg Ser Pro His Arg
                 245                 250                 255

 Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn Ala Ser Thr Val Val
                 260                 265                 270

 Gly Gly Asp Val Glu Phe Val Cys Lys Val Tyr Ser Asp Ala Gln
                 275                 280                 285

 Pro His Ile Gln Trp Ile Lys His Val Glu Lys Asn Gly Ser Lys
                 290                 295                 300

 Tyr Gly Pro Asp Gly Leu Pro Tyr Leu Lys Val Leu Lys Ala Ala
                 305                 310                 315

 Gly Val Asn Thr Thr Asp Lys Glu Ile Glu Val Leu Tyr Ile Arg
                 320                 325                 330

 Asn Val Thr Phe Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly
                 335                 340                 345

 Asn Ser Ile Gly Ile Ser Phe His Ser Ala Trp Leu Thr Val Leu
                 350                 355                 360

 Pro Ala Pro Gly Arg Glu Lys Glu Ile Thr Ala Ser Pro Asp Tyr
                 365                 370                 375

 Leu Glu Ile Ala Ile Tyr Cys Ile Gly Val Phe Leu Ile Ala Cys
                 380                 385                 390

 Met Val Val Thr Val Ile Leu Cys Arg Met Lys Asn Thr Thr Lys
                 395                 400                 405

 Lys Pro Asp Phe Ser Ser Gln Pro Ala Val His Lys Leu Thr Lys
                 410                 415                 420

 Arg Ile Pro Leu Arg Arg Gln Val Thr Val Ser Ala Glu Ser Ser
                 425                 430                 435

 Ser Ser Met Asn Ser Asn Thr Pro Leu Val Arg Ile Thr Thr Arg
                 440                 445                 450

 Leu Ser Ser Thr Ala Asp Thr Pro Met Leu Ala Gly Val Ser Glu
                 455                 460                 465

 Tyr Glu Leu Pro Glu Asp Pro Lys Trp Glu Phe Pro Arg Asp Lys
                 470                 475                 480

 Leu Thr Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val
                 485                 490                 495

 Val Met Ala Glu Ala Val Gly Ile Asp Lys Asp Lys Pro Lys Glu
                 500                 505                 510

 Ala Val Thr Val Ala Val Lys Met Leu Lys Asp Asp Ala Thr Glu
                 515                 520                 525

 Lys Asp Leu Ser Asp Leu Val Ser Glu Met Glu Met Met Lys Met
                 530                 535                 540

 Ile Gly Lys His Lys Asn Ile Ile Asn Leu Leu Gly Ala Cys Thr
                 545                 550                 555

 Gln Asp Gly Pro Leu Tyr Val Ile Val Glu Tyr Ala Ser Lys Gly
                 560                 565                 570

 Asn Leu Arg Glu Tyr Leu Arg Ala Arg Arg Pro Pro Gly Met Glu
                 575                 580                 585

 Tyr Ser Tyr Asp Ile Asn Arg Val Pro Glu Glu Gln Met Thr Phe
                 590                 595                 600

 Lys Asp Leu Val Ser Cys Thr Tyr Gln Leu Ala Arg Gly Met Glu
                 605                 610                 615

 Tyr Leu Ala Ser Gln Lys Cys Ile His Arg Asp Leu Ala Ala Arg
                 620                 625                 630

 Asn Val Leu Val Thr Glu Asn Asn Val Met Lys Ile Ala Asp Phe
                 635                 640                 645

 Gly Leu Ala Arg Asp Ile Asn Asn Ile Asp Tyr Tyr Lys Lys Thr
                 650                 655                 660

 Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ala Leu
                 665                 670                 675

 Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val Trp Ser Phe Gly
                 680                 685                 690

 Val Leu Met Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr Pro
                 695                 700                 705

 Gly Ile Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly His
                 710                 715                 720

 Arg Met Asp Lys Pro Ala Asn Cys Thr Asn Glu Leu Tyr Met Met
                 725                 730                 735

 Met Arg Asp Cys Trp His Ala Val Pro Ser Gln Arg Pro Thr Phe
                 740                 745                 750

 Lys Gln Leu Val Glu Asp Leu Asp Arg Ile Leu Thr Leu Thr Thr
                 755                 760                 765

 Asn Glu Glu Tyr Leu Asp Leu Ser Gln Pro Leu Glu Gln Tyr Ser
                 770                 775                 780

 Pro Ser Tyr Pro Asp Thr Arg Ser Ser Cys Ser Ser Gly Asp Asp
                 785                 790                 795

 Ser Val Phe Ser Pro Asp Pro Met Pro Tyr Glu Pro Cys Leu Pro
                 800                 805                 810

 Gln Tyr Pro His Ile Asn Gly Ser Val Lys Thr
                 815                 820    

<210> 2
<211> 822
<212> PRT
<213> Homo sapiens

<400> 2
 Met Val Ser Trp Gly Arg Phe Ile Cys Leu Val Val Val Thr Met
   1               5                  10                  15

 Ala Thr Leu Ser Leu Ala Arg Pro Ser Phe Ser Leu Val Glu Asp
                  20                  25                  30

 Thr Thr Leu Glu Pro Glu Glu Pro Pro Thr Lys Tyr Gln Ile Ser
                  35                  40                  45

 Gln Pro Glu Val Tyr Val Ala Ala Pro Gly Glu Ser Leu Glu Val
                  50                  55                  60

 Arg Cys Leu Leu Lys Asp Ala Ala Val Ile Ser Trp Thr Lys Asp
                  65                  70                  75

 Gly Val His Leu Gly Pro Asn Asn Arg Thr Val Leu Ile Gly Glu
                  80                  85                  90

 Tyr Leu Gln Ile Lys Gly Ala Thr Pro Arg Asp Ser Gly Leu Tyr
                  95                 100                 105

 Ala Cys Thr Ala Ser Arg Thr Val Asp Ser Glu Thr Trp Tyr Phe
                 110                 115                 120

 Met Val Asn Val Thr Asp Ala Ile Ser Ser Gly Asp Asp Glu Asp
                 125                 130                 135

 Asp Thr Asp Gly Ala Glu Asp Phe Val Ser Glu Asn Ser Asn Asn
                 140                 145                 150

 Lys Arg Ala Pro Tyr Trp Thr Asn Thr Glu Lys Met Glu Lys Arg
                 155                 160                 165

 Leu His Ala Val Pro Ala Ala Asn Thr Val Lys Phe Arg Cys Pro
                 170                 175                 180

 Ala Gly Gly Asn Pro Met Pro Thr Met Arg Trp Leu Lys Asn Gly
                 185                 190                 195

 Lys Glu Phe Lys Gln Glu His Arg Ile Gly Gly Tyr Lys Val Arg
                 200                 205                 210

 Asn Gln His Trp Ser Leu Ile Met Glu Ser Val Val Pro Ser Asp
                 215                 220                 225

 Lys Gly Asn Tyr Thr Cys Val Val Glu Asn Glu Tyr Gly Ser Ile
                 230                 235                 240

 Asn His Thr Tyr His Leu Asp Val Val Glu Arg Ser Pro His Arg
                 245                 250                 255

 Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn Ala Ser Thr Val Val
                 260                 265                 270

 Gly Gly Asp Val Glu Phe Val Cys Lys Val Tyr Ser Asp Ala Gln
                 275                 280                 285

 Pro His Ile Gln Trp Ile Lys His Val Glu Lys Asn Gly Ser Lys
                 290                 295                 300

 Tyr Gly Pro Asp Gly Leu Pro Tyr Leu Lys Val Leu Lys His Ser
                 305                 310                 315

 Gly Ile Asn Ser Ser Asn Ala Glu Val Leu Ala Leu Phe Asn Val
                 320                 325                 330

 Thr Glu Ala Asp Ala Gly Glu Tyr Ile Cys Lys Val Ser Asn Tyr
                 335                 340                 345

 Ile Gly Gln Ala Asn Gln Ser Ala Trp Leu Thr Val Leu Pro Lys
                 350                 355                 360

 Gln Gln Ala Pro Gly Arg Glu Lys Glu Ile Thr Ala Ser Pro Asp
                 365                 370                 375

 Tyr Leu Glu Ile Ala Ile Tyr Cys Ile Gly Val Phe Leu Ile Ala
                 380                 385                 390

 Cys Met Val Val Thr Val Ile Leu Cys Arg Met Lys Asn Thr Thr
                 395                 400                 405

 Lys Lys Pro Asp Phe Ser Ser Gln Pro Ala Val His Lys Leu Thr
                 410                 415                 420

 Lys Arg Ile Pro Leu Arg Arg Gln Val Thr Val Ser Ala Glu Ser
                 425                 430                 435

 Ser Ser Ser Met Asn Ser Asn Thr Pro Leu Val Arg Ile Thr Thr
                 440                 445                 450

 Arg Leu Ser Ser Thr Ala Asp Thr Pro Met Leu Ala Gly Val Ser
                 455                 460                 465

 Glu Tyr Glu Leu Pro Glu Asp Pro Lys Trp Glu Phe Pro Arg Asp
                 470                 475                 480

 Lys Leu Thr Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln
                 485                 490                 495

 Val Val Met Ala Glu Ala Val Gly Ile Asp Lys Asp Lys Pro Lys
                 500                 505                 510

 Glu Ala Val Thr Val Ala Val Lys Met Leu Lys Asp Asp Ala Thr
                 515                 520                 525

 Glu Lys Asp Leu Ser Asp Leu Val Ser Glu Met Glu Met Met Lys
                 530                 535                 540

 Met Ile Gly Lys His Lys Asn Ile Ile Asn Leu Leu Gly Ala Cys
                 545                 550                 555

 Thr Gln Asp Gly Pro Leu Tyr Val Ile Val Glu Tyr Ala Ser Lys
                 560                 565                 570

 Gly Asn Leu Arg Glu Tyr Leu Arg Ala Arg Arg Pro Pro Gly Met
                 575                 580                 585

 Glu Tyr Ser Tyr Asp Ile Asn Arg Val Pro Glu Glu Gln Met Thr
                 590                 595                 600

 Phe Lys Asp Leu Val Ser Cys Thr Tyr Gln Leu Ala Arg Arg Met
                 605                 610                 615

 Glu Tyr Leu Ala Ser Gln Lys Cys Ile His Arg Asp Leu Ala Ala
                 620                 625                 630

 Arg Asn Val Leu Val Thr Glu Asn Asn Val Met Lys Ile Ala Asp
                 635                 640                 645

 Phe Gly Leu Ala Arg Asp Ile Asn Asn Ile Asp Tyr Tyr Lys Lys
                 650                 655                 660

 Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ala
                 665                 670                 675

 Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val Trp Ser Phe
                 680                 685                 690

 Gly Val Leu Met Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr
                 695                 700                 705

 Pro Gly Ile Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly
                 710                 715                 720

 His Arg Met Asp Lys Pro Ala Asn Cys Thr Asn Glu Leu Tyr Met
                 725                 730                 735

 Met Met Arg Asp Cys Trp His Ala Val Pro Ser Gln Arg Pro Thr
                 740                 745                 750

 Phe Lys Gln Leu Val Glu Asp Leu Asp Arg Ile Leu Thr Leu Thr
                 755                 760                 765

 Thr Asn Glu Glu Tyr Leu Asp Leu Ser Gln Pro Leu Glu Gln Tyr
                 770                 775                 780

 Ser Pro Ser Tyr Pro Asp Thr Arg Ser Ser Cys Ser Ser Gly Asp
                 785                 790                 795

 Asp Ser Val Phe Ser Pro Asp Pro Met Pro Tyr Glu Pro Cys Leu
                 800                 805                 810

 Pro Gln Tyr Pro His Ile Asn Gly Ser Val Lys Thr
                 815                 820        

