                              Sequence Listing

<110> Weilan Ye, et al.

<120> ANTIBODIES TO EGFL7 AND METHODS FOR THEIR USE

<130> P2327R1


<150> US 60/783,686
<151> 2006-03-16

<150> US 60/812,569
<151> 2006-06-09

<160> 33

<210> 1
<211> 112
<212> PRT
<213> Mus musculus

<400> 1
 Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu
   1               5                  10                  15

 Gly Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp
                  20                  25                  30

 Tyr Asp Gly Asp Ser Tyr Met Ser Trp Tyr Gln Gln Lys Pro Gly
                  35                  40                  45

 Gln Pro Pro Lys Leu Leu Ile Tyr Gly Ala Ser Asn Leu Glu Ser
                  50                  55                  60

 Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe
                  65                  70                  75

 Thr Leu Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr
                  80                  85                  90

 Tyr Cys Gln Gln Asn Asn Glu Asp Pro Tyr Thr Phe Gly Gly Gly
                  95                 100                 105

 Thr Lys Val Glu Ile Lys Arg
                 110        

<210> 2
<211> 117
<212> PRT
<213> Mus musculus

<400> 2
 Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly
   1               5                  10                  15

 Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly His Thr Phe Thr
                  20                  25                  30

 Thr Tyr Gly Met Ser Trp Val Lys Gln Ala Pro Gly Lys Gly Leu
                  35                  40                  45

 Lys Trp Met Gly Trp Ile Asn Thr His Ser Gly Val Pro Thr Tyr
                  50                  55                  60

 Ala Asp Asp Phe Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser
                  65                  70                  75

 Ala Ser Thr Ala His Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp
                  80                  85                  90

 Thr Ala Thr Tyr Phe Cys Ala Arg Leu Gly Ser Ser Ala Val Asp
                  95                 100                 105

 Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
                 110                 115        

<210> 3
<211> 113
<212> PRT
<213> Mus musculus

<400> 3
 Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu
   1               5                  10                  15

 Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val
                  20                  25                  30

 His Thr Asn Gly Ile Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro
                  35                  40                  45

 Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe
                  50                  55                  60

 Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp
                  65                  70                  75

 Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val
                  80                  85                  90

 Tyr Phe Cys Ser Gln Ser Thr His Val Pro Leu Thr Phe Gly Ala
                  95                 100                 105

 Gly Thr Lys Val Glu Ile Lys Arg
                 110            

<210> 4
<211> 128
<212> PRT
<213> Mus musculus

<400> 4
 Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly
   1               5                  10                  15

 Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser
                  20                  25                  30

 Asp Tyr Tyr Met Asn Ser Asp Tyr Tyr Met Asn Trp Val Lys Gln
                  35                  40                  45

 Ser His Gly Lys Ser Leu Glu Trp Ile Gly Asp Ile Asn Pro Lys
                  50                  55                  60

 Asn Gly Gly Thr Thr Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr
                  65                  70                  75

 Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Arg
                  80                  85                  90

 Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Glu
                  95                 100                 105

 Ala Asp Tyr Asp Pro Ile Tyr Tyr Ala Met Asp Tyr Trp Gly Gln
                 110                 115                 120

 Gly Thr Thr Leu Thr Val Ser Ala
                 125            

<210> 5
<211> 15
<212> PRT
<213> Mus musculus

<400> 5
 Lys Ala Ser Gln Ser Val Asp Tyr Asp Gly Asp Ser Tyr Met Ser
   1               5                  10                  15

<210> 6
<211> 7
<212> PRT
<213> Mus musculus

<400> 6
 Gly Ala Ser Asn Leu Glu Ser
                   5        

<210> 7
<211> 9
<212> PRT
<213> Mus musculus

<400> 7
 Gln Gln Asn Asn Glu Asp Pro Tyr Thr
                   5                

<210> 8
<211> 5
<212> PRT
<213> Mus musculus

<400> 8
 Thr Tyr Gly Met Ser
                   5

<210> 9
<211> 17
<212> PRT
<213> Mus musculus

<400> 9
 Trp Ile Asn Thr His Ser Gly Val Pro Thr Tyr Ala Asp Asp Phe
   1               5                  10                  15

 Lys Gly
        

<210> 10
<211> 5
<212> PRT
<213> Mus musculus

<400> 10
 Leu Gly Ser Ser Ala
                   5

<210> 11
<211> 16
<212> PRT
<213> Mus musculus

<400> 11
 Arg Ser Ser Gln Ser Leu Val His Thr Asn Gly Ile Thr Tyr Leu
   1               5                  10                  15

 His
    

<210> 12
<211> 7
<212> PRT
<213> Mus musculus

<400> 12
 Lys Val Ser Asn Arg Phe Ser
                   5        

<210> 13
<211> 9
<212> PRT
<213> Mus musculus

<400> 13
 Ser Gln Ser Thr His Val Pro Leu Thr
                   5                

<210> 14
<211> 11
<212> PRT
<213> Mus musculus

<400> 14
 Asp Tyr Tyr Met Asn Ser Asp Tyr Tyr Met Asn
                   5                  10    

<210> 15
<211> 17
<212> PRT
<213> Mus musculus

<400> 15
 Asp Ile Asn Pro Lys Asn Gly Gly Thr Thr Tyr Asn Gln Lys Phe
   1               5                  10                  15

 Lys Gly
        

<210> 16
<211> 7
<212> PRT
<213> Mus musculus

<400> 16
 Ala Leu Gly Val Phe Asp Tyr
                   5        

<210> 17
<211> 108
<212> PRT
<213> Homo sapiens

<400> 17
 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser
                  20                  25                  30

 Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys
                  35                  40                  45

 Leu Leu Ile Tyr Ala Ala Ser Ser Leu Glu Ser Gly Val Pro Ser
                  50                  55                  60

 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile
                  65                  70                  75

 Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln
                  80                  85                  90

 Tyr Asn Ser Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu
                  95                 100                 105

 Ile Lys Arg
            

<210> 18
<211> 112
<212> PRT
<213> Homo sapiens

<400> 18
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser
                  20                  25                  30

 Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
                  35                  40                  45

 Glu Trp Val Ser Val Ile Ser Gly Asp Gly Gly Ser Thr Tyr Tyr
                  50                  55                  60

 Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser
                  65                  70                  75

 Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Ala Arg Phe Asp Tyr Trp Gly Gln Gly
                  95                 100                 105

 Thr Leu Val Thr Val Ser Ala
                 110        

<210> 19
<211> 6
<212> DNA
<213> Artificial sequence

<220>
<223> sequence is synthesized

<220>
<221> modified_base
<222> 2
<223> base is g, a, t or c

<220>
<221> CAAT_signal modified_base
<222> full
<223> CAAT box

<400> 19
 cncaat 6

<210> 20
<211> 6
<212> DNA
<213> Artificial sequence

<220>
<223> sequence is synthesized

<220>
<221> polyA_signal
<222> full
<223> polyadenylation signal

<400> 20
 aataaa 6

<210> 21
<211> 30
<212> DNA
<213> Artificial sequence

<220>
<223> sequence is synthesized

<220>
<221> Modified_base
<222> full
<223> Primer for amplification of antibody sequence

<220>
<221> modified_base
<222> 13
<223> base is g or t

<220>
<221> modified_base
<222> 16
<223> base is g or c

<220>
<221> modified_base
<222> 19
<223> base is a or c

<220>
<221> modified_base
<222> 22
<223> base is g or a

<220>
<221> modified_base
<222> 28
<223> base is a or t

<400> 21
 gtcagatatc gtkctsacmc artctccwgc 30

<210> 22
<211> 74
<212> DNA
<213> Artificial sequence

<220>
<223> sequence is synthesized

<220>
<221> Modified_base
<222> full
<223> Primer for amplification of antibody sequence

<220>
<221> modified_base
<222> 20, 57
<223> base is a or c or t

<220>
<221> modified_base
<222> 23,32,60,69
<223> base is  g or a

<220>
<221> modified_base
<222> 24, 61
<223> base is t or c

<400> 22
 gatcgacgta cgctcagath carytggtgc artctgggat cgacgtacgc 50

 tcagathcar ytggtgcart  ctgg 74

<210> 23
<211> 30
<212> DNA
<213> Artificial sequence

<220>
<223> sequence is synthesized

<220>
<221> Modified_base
<222> full
<223> Primer for amplification of antibody sequence

<220>
<221> modified_base
<222> 19
<223> base is g or c or t

<220>
<221> modified_base
<222> 22
<223> base is g or a

<400> 23
 gatcgatatc gtgatgacbc aractccact 30

<210> 24
<211> 37
<212> DNA
<213> Artificial sequence

<220>
<223> sequence is synthesized

<220>
<221> Modified_base
<222> full
<223> Primer for amplification of antibody sequence

<220>
<221> modified_base
<222> 20
<223> base is t or c

<220>
<221> modified_base
<222> 26
<223> base is g or c

<400> 24
 gatcgacgta cgctgaggty cagctscagc  agtctgg 37

<210> 25
<211> 21
<212> DNA
<213> Artificial sequence

<220>
<223> sequence is synthesized

<220>
<221> modified_base
<222> 4
<223> base is a or g or t

<220>
<221> modified_base
<222> 6
<223> base is g or t

<220>
<221> modified_base
<222> 7
<223> base is t or c

<220>
<221> Modified_base
<222> full
<223> Primer for amplification of antibody sequence

<400> 25
 tttdakytcc agcttggtac  c 21

<210> 26
<211> 43
<212> DNA
<213> Artificial sequence

<220>
<223> sequence is synthesized

<220>
<221> Modified_base
<222> full
<223> Primer for amplification of antibody sequence

<220>
<221> modified_base
<222> 25
<223> base is a or c

<220>
<221> modified_base
<222> 26,39
<223> base is g or a

<220>
<221> modified_base
<222> 32, 40
<223> base is a or g or t

<220>
<221> modified_base
<222> 37
<223> base is g or c

<220>
<221> modified_base
<222> 38
<223> base is a or c or t

<400> 26
 acagtgggcc cttggtggag gctgmrgaga cdgtgashrd  rgt 43

<210> 27
<211> 13
<212> PRT
<213> Homo sapiens

<400> 27
 Arg Ser Pro Gly Leu Ala Pro Ala Arg Pro Arg Tyr Ala
                   5                  10            

<210> 28
<211> 13
<212> PRT
<213> Homo sapiens

<400> 28
 Arg Pro Arg Tyr Ala Cys Cys Pro Gly Trp Lys Arg Thr
                   5                  10            

<210> 29
<211> 13
<212> PRT
<213> Homo sapiens

<400> 29
 Gly Trp Lys Arg Thr Ser Gly Leu Pro Gly Ala Cys Gly
                   5                  10            

<210> 30
<211> 13
<212> PRT
<213> Homo sapiens

<400> 30
 Leu Thr Thr Cys Asp Gly His Arg Ala Cys Ser Thr Tyr
                   5                  10            

<210> 31
<211> 13
<212> PRT
<213> Homo sapiens

<400> 31
 Arg Ala Cys Ser Thr Tyr Arg Thr Ile Tyr Arg Thr Ala
                   5                  10            

<210> 32
<211> 13
<212> PRT
<213> Homo sapiens

<400> 32
 Arg Thr Ala Tyr Arg Arg Ser Pro Gly Val Thr Pro Ala
                   5                  10            

<210> 33
<211> 4
<212> PRT
<213> Homo sapiens

<400> 33
 Arg Thr Ile Tyr
                

