
                                SEQUENCE LISTING

<110> Zhu,  Zhenglun
      Gao, Hong

<120> TREATMENT OF DEVELOPMENT-RELATED
  DISORDERS

<130> 20450-002WO1

<140> PCT/US2007/062587   
<141> 2007-02-22  

<150> US 60/775,645       
<151> 2006-02-22  

<160> 16

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 59
<212> PRT
<213> Homo sapiens

<400> 1
Arg Val Arg Thr Ala Phe Thr Met Glu Gln Val Arg Thr Leu Glu Gly
 1               5                  10                  15      
Val Phe Gln His His Gln Tyr Leu Ser Pro Leu Glu Arg Lys Arg Leu
            20                  25                  30          
Ala Arg Glu Met Gln Leu Ser Glu Val Gln Ile Lys Thr Trp Phe Gln
        35                  40                  45              
Asn Arg Arg Met Lys His Lys Arg Gln Met Gln
    50                  55                  


<210> 2
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetically generated peptide

<400> 2
Thr Asp Ser Gly Tyr Glu Ser Glu Thr Ser Cys
 1               5                  10      


<210> 3
<211> 58
<212> PRT
<213> Homo sapiens

<400> 3
Arg Leu Arg Thr Ala Phe Thr Ser Asp Gln Ile Ser Thr Leu Glu Lys
 1               5                  10                  15      
Thr Phe Gln Lys His Arg Tyr Leu Gly Ala Ser Glu Arg Gln Lys Leu
            20                  25                  30          
Ala Ala Lys Leu Gln Leu Ser Glu Val Gln Ile Lys Thr Trp Phe Gln
        35                  40                  45              
Asn Arg Arg Met Lys Tyr Lys Arg Glu Ile
    50                  55              


<210> 4
<211> 993
<212> DNA
<213> Homo sapiens

<400> 4
gacaagatga ctaaagcttt ctcctctgtt gaatggcttg ctcaaagcag ccgcagatct 60
cacagagagc agccaagcaa agtggatcag agatattcac cgtaccccag gccatccctg 120
ccttcctgga acagtgatgt gtccccttct tcatggaaca gccaactatc tccagatcca 180
gacagtgccc aagtctcacc atgccctgtg agtgcacaag tatctccata ttcctcagac 240
agtgaaatat cactgtattc acatgaagaa gaagcctctt tctatggaat ggactttaat 300
acatcatcat cccctggaga caatggattg ctacacaggg acacaacctc atactccaga 360
ggaatggagg ccatgtcggc cagcactcca gcaacatcac ctgtgaaagg ggcacaacct 420
gttgattccg cctacagcac tagcactgac tcaggctatg aaagtgaaac gagtcgatcc 480
aactctacag cccctgaagg agatgcctcc gtatctctga gtcccaatga tacctcagat 540
gaagagggca agatgggccg aaggttgagg acggctttca ccagtgatca gatctccact 600
ctggagaaga cttttcagaa acacagatac cttggggcgt ctgaaagacg gaaactcgca 660
gccaaactcc agctttctga agtccagatt aaaacttggt tccagaaccg caggatgaaa 720
tacaaacggg aaatccaaga tggcagacca gactcatacc acccagccca gttctttggt 780
gtgtacggct atgcacagca gcccactcct gtattccagc atgcagtcca acatccctac 840
ccaggttata acccactaat ggaaaccctg cctggtacca tgccctatac catgcatcca 900
cctgccatgg actctctgac tcccttcaac tctcaacctt ttcagatgct ctacctgccc 960
caacagcacc ttgggcaacc tctggcctat tag                              993

<210> 5
<211> 258
<212> PRT
<213> Homo sapiens

<400> 5
Met Arg Leu Ser Ser Ser Pro Pro Arg Gly Pro Gln Gln Leu Ser Ser
 1               5                  10                  15      
Phe Gly Ser Val Asp Trp Leu Ser Gln Ser Ser Cys Ser Gly Pro Thr
            20                  25                  30          
His Thr Pro Arg Pro Ala Asp Phe Ser Leu Gly Ser Leu Pro Gly Pro
        35                  40                  45              
Gly Gln Thr Ser Gly Ala Arg Glu Pro Pro Gln Ala Val Ser Ile Lys
    50                  55                  60                  
Glu Ala Ala Gly Ser Ser Asn Leu Pro Ala Pro Glu Arg Thr Met Ala
65                  70                  75                  80  
Gly Leu Ser Lys Glu Pro Asn Thr Leu Arg Ala Pro Arg Val Arg Thr
                85                  90                  95      
Ala Phe Thr Met Glu Gln Val Arg Thr Leu Glu Gly Val Phe Gln His
            100                 105                 110         
His Gln Tyr Leu Ser Pro Leu Glu Arg Lys Arg Leu Ala Arg Glu Met
        115                 120                 125             
Gln Leu Ser Glu Val Gln Ile Lys Thr Trp Phe Gln Asn Arg Arg Met
    130                 135                 140                 
Lys His Lys Arg Gln Met Gln Asp Pro Gln Leu His Ser Pro Phe Ser
145                 150                 155                 160 
Gly Ser Leu His Ala Pro Pro Ala Phe Tyr Ser Thr Ser Ser Gly Leu
                165                 170                 175     
Ala Asn Gly Leu Gln Leu Leu Cys Pro Trp Ala Pro Leu Ser Gly Pro
            180                 185                 190         
Gln Ala Leu Met Leu Pro Pro Gly Ser Phe Trp Gly Leu Cys Gln Val
        195                 200                 205             
Ala Gln Glu Ala Leu Ala Ser Ala Gly Ala Ser Cys Cys Gly Gln Pro
    210                 215                 220                 
Leu Ala Ser His Pro Pro Thr Pro Gly Arg Pro Ser Leu Gly Pro Ala
225                 230                 235                 240 
Leu Ser Thr Gly Pro Arg Gly Leu Cys Ala Met Pro Gln Thr Gly Asp
                245                 250                 255     
Ala Phe
        


<210> 6
<211> 777
<212> DNA
<213> Homo sapiens

<400> 6
atgcgcctct cctcctcccc acctcgtggc ccgcagcagc tctccagctt tggctccgtg 60
gactggctct cccagagcag ctgctcaggg ccgacccaca cccccaggcc tgccgacttc 120
tccctgggga gcctccctgg cccaggccag acatccggcg cccgggagcc ccctcaggcc 180
gtcagcatca aggaggccgc cgggtcctca aatctgcctg cgccggagag gaccatggcc 240
gggttgagta aggagccaaa taccttgcgg gccccccgtg tccgcacagc cttcaccatg 300
gagcaggtcc gcaccttgga gggcgtcttc cagcaccacc agtacctgag ccctctggag 360
cggaagaggc tggccaggga gatgcagctc tcagaggtcc agataaaaac ctggtttcag 420
aatcgccgca tgaaacacaa acggcaaatg caggaccccc agctgcacag ccccttctcg 480
gggtctctcc atgcgccccc agctttctac tcaacgtctt ctggccttgc caatggcctg 540
cagctgctgt gcccttgggc acccctgtcc gggccccagg ctctgatgct gccccctggc 600
tccttctggg gtctctgcca agtggcacaa gaggccctgg catctgcggg agcttcctgc 660
tgcgggcagc ctctggcgtc ccacccccct accccaggcc ggccttcgct gggaccagcc 720
ctgtccacgg ggccccgggg cctgtgtgct atgccacaga cgggggatgc attttga    777

<210> 7
<211> 327
<212> PRT
<213> Homo sapiens

<400> 7
Met Thr Lys Ala Phe Ser Ser Val Glu Trp Leu Ala Gln Ser Ser Arg
 1               5                  10                  15      
Arg Ser His Arg Glu Gln Pro Ser Lys Val Asp Gln Arg Tyr Ser Pro
            20                  25                  30          
Tyr Pro Ser Pro Ser Leu Pro Ser Trp Asn Ser Asp Val Ser Pro Ser
        35                  40                  45              
Ser Trp Asn Ser Gln Leu Ser Pro Asp Pro Asp Ser Ala Gln Val Ser
    50                  55                  60                  
Pro Cys Pro Ala Ser Ala Gln Val Ser Pro Tyr Ser Ser Asp Ser Glu
65                  70                  75                  80  
Ile Ser Leu Tyr Ser His Glu Glu Glu Ala Ser Phe Tyr Gly Met Asp
                85                  90                  95      
Leu Asn Thr Ser Ser Ser Pro Gly Asp Asn Gly Leu Leu His Ser Glu
            100                 105                 110         
Met Val Ser Val Pro Asp Asn Ile Pro Arg Ala Ser Ser Asp Glu Asp
        115                 120                 125             
Ala Ala Lys Ser Ala Tyr Ser Thr Ser Thr Asp Ser Gly Tyr Glu Ser
    130                 135                 140                 
Glu Thr Ser Cys Ser Ser Ser Thr Ala Pro Glu Gly Asp Ala Ile Ser
145                 150                 155                 160 
Leu Ser Pro Asn Asp Thr Ser Asp Glu Glu Gly Lys Met Gly Arg Arg
                165                 170                 175     
Leu Arg Thr Ala Phe Thr Ser Asp Gln Ile Ser Thr Leu Glu Lys Thr
            180                 185                 190         
Phe Gln Lys His Arg Tyr Leu Gly Ala Ser Glu Arg Gln Lys Leu Ala
        195                 200                 205             
Ala Lys Leu Gln Leu Ser Glu Val Gln Ile Lys Thr Trp Phe Gln Asn
    210                 215                 220                 
Arg Arg Met Lys Tyr Lys Arg Glu Ile Gln Asp Gly Arg Pro Asp Ser
225                 230                 235                 240 
Tyr His Pro Ala Gln Phe Phe Gly Val Tyr Gly Tyr Ala Gln Gln Pro
                245                 250                 255     
Thr Pro Val Phe Gln His Ala Val Gln His Pro Tyr Pro Gly Tyr Asn
            260                 265                 270         
Pro Leu Met Glu Thr Leu Pro Gly Thr Met Pro Tyr Thr Met His Pro
        275                 280                 285             
Pro Ala Met Asp Ser Met Thr Pro Phe Asn Ser Gln Pro Phe Gln Met
    290                 295                 300                 
Leu Tyr Leu Pro Gln Gln His Leu Gly Gln Pro Leu Thr Tyr Gln Glu
305                 310                 315                 320 
Glu Arg Pro Phe Val Arg Tyr
                325         


<210> 8
<211> 987
<212> DNA
<213> Homo sapiens

<400> 8
atgactaaag ctttctcctc tgttgaatgg cttgctcaaa gcagccgcag atctcacaga 60
gagcagccaa gcaaagtgga tcagagatat tcaccgtacc ccaggccatc cctgccttcc 120
tggaacagtg atgtgtcccc ttcttcatgg aacagccaac tatctccaga tccagacagt 180
gcccaagtct caccatgccc tgtgagtgca caagtatctc catattcctc agacagtgaa 240
atatcactgt attcacatga agaagaagcc tctttctatg gaatggactt taatacatca 300
tcatcccctg gagacaatgg attgctacac agggacacaa cctcatactc cagaggaatg 360
gaggccatgt cggccagcac tccagcaaca tcacctgtga aaggggcaca acctgttgat 420
tccgcctaca gcactagcac tgactcaggc tatgaaagtg aaacgagtcg atccaactct 480
acagcccctg aaggagatgc ctccgtatct ctgagtccca atgatacctc agatgaagag 540
ggcaagatgg gccgaaggtt gaggacggct ttcaccagtg atcagatctc cactctggag 600
aagacttttc agaaacacag ataccttggg gcgtctgaaa gacggaaact cgcagccaaa 660
ctccagcttt ctgaagtcca gattaaaact tggttccaga accgcaggat gaaatacaaa 720
cgggaaatcc aagatggcag accagactca taccacccag cccagttctt tggtgtgtac 780
ggctatgcac agcagcccac tcctgtattc cagcatgcag tccaacatcc ctacccaggt 840
tataacccac taatggaaac cctgcctggt accatgccct ataccatgca tccacctgcc 900
atggactctc tgactccctt caactctcaa ccttttcaga tgctctacct gccccaacag 960
caccttgggc aacctctggc ctattag                                     987

<210> 9
<211> 2428
<212> DNA
<213> Homo sapiens

<400> 9
acctggccgc catgcgcctc tcctcctccc cacctcgtgg cccgcagcag ctctccagct 60
ttggctccgt ggactggctc tcccagagca gctgctcagg gccgacccac acccccaggc 120
ctgccgactt ctccctgggg agcctccctg gcccaggcca gacatccggc gcccgggagc 180
cccctcaggc cgtcagcatc aaggaggccg ccgggtcctc aaatctgcct gcgccggaga 240
ggaccatggc cgggttgagt aaggagccaa ataccttgcg ggccccccgt gtccgcacag 300
ccttcaccat ggagcaggtc cgcaccttgg agggcgtctt ccagcaccac cagtacctga 360
gccctctgga gcggaagagg ctggccaggg agatgcagct ctcagaggtc cagataaaaa 420
cctggtttca gaatcgccgc atgaaacaca aacggcaaat gcaggacccc cagctgcaca 480
gccccttctc ggggtctctc catgcgcccc cagctttcta ctcaacgtct tctggccttg 540
ccaatggcct gcagctgctg tgcccttggg cacccctgtc cgggccccag gctctgatgc 600
tgccccctgg ctccttctgg ggtctctgcc aagtggcaca agaggccctg gcatctgcgg 660
gagcttcctg ctgcgggcag cctctggcgt cccacccccc taccccaggc cggccttcgc 720
tgggaccagc cctgtccacg gggccccggg gcctgtgtgc tatgccacag acgggggatg 780
cattttgagg aggcacctct gactcccaca ctcgcggtct tgctgatcgc acctggctcc 840
tacctggagg actcagttgt tctgtttaca tcctggtggc acctctcacc ctgacccaca 900
caaaggttct ggagattact ggagaatata tataaatata tatatgtacg tatatatgta 960
aatacacata tacgtatata taaatatata tatacatatg tgtgtgtata tatatatata 1020
tttttttttt tttttttttt tttgagacgg agtgttgctc tgtcacccag gctggagtgc 1080
aatgacgcaa tctcggctca ctgcaacctc cgcctcctgg gttcaagcga ttctccagcc 1140
tcagcctccc gagtagctgg gattacagac acccgccacc acgcccggct aattttttct 1200
atttttagta gaaatggggt ttcaccatgt tagccaggct ggtctcaaac tcctgaccct 1260
gtgatccgcc cgcctcggcc tcccaaagtg ctgggattac aggcatgagc cactgcaccc 1320
ggccctgaga atatatttat taaagccacc tcttcactga aagttaccga aagagtcggt 1380
ttaggaagga aacgaagggt cagtgaacag agtcaaatgc agaagtgggc ttgtcatggg 1440
tagggctttc ggcgtacgat aaaaggatca tttgtttttt aaaaggggtt ggaaaaactg 1500
gttttccagt tggaaacagt aaaggttgta agctttgtgt gtacaaaaga aaacagggaa 1560
tgcaggtgtg tttatagcgt tgtggttcaa gtccctctta acaagaactc caaagctgga 1620
aagcaggagg gaacaaaggt gaacatgaag gcgaggatgc tggggccctg cagtgcgctc 1680
taggctgtgc gtgagccggg actgtaccca cagcttgctg agggctgctc ttcttgggcc 1740
agggaaagca gggcagccgg gacctgcggc tgtgcctgga ctgaagctgt cccgcaggtc 1800
cccaccctcc aacacgtgct cacctgtccc cctcctcgca gcagcctcgg gacaaaacaa 1860
tgactcaagg acagcacttc tcgcagaagg tctggaagtg cccagaatgg gaggcacgga 1920
agcccctccc ggggaggact cccgcgttga tggaccgttc ttggtgcaga ctcctgactg 1980
cgtgcatgaa acctgagaca agtgcaattc cttccatgtc gccccagagt gcccaggagg 2040
caggcagtgc ggggtgccca ggcagacggg ttcagcctgc agaactggag gcgacctgtg 2100
aaacccaccc gggcacccca acaggaacag aagcgtggtc ctgcggctgc gtccccagcg 2160
agtttcactt tccccttgct cgtttctccc ttgttgtaag tgtttacaac tggcatgtgc 2220
ttttaaacgt caggtaagag gggaacagct gctgtacatc gtcctggcga gtgacaatgt 2280
gacagaagcc tgggcgaggc cctcggaggg cagcagctgg acaggggcta ctgggtttgg 2340
cctggacagc actgatttgt ggatgtggat gggggcacgt tgtccgtgat aaaagtacaa 2400
gtgcccctca caaaaaaaaa aaaaaaaa                                    2428

<210> 10
<211> 1281
<212> DNA
<213> Homo sapiens

<400> 10
agaacacaag gactaataca gacaagatga ctaaagcttt ctcctctgtt gaatggcttg 60
ctcaaagcag ccgcagatct cacagagagc agccaagcaa agtggatcag agatattcac 120
cgtaccccag gccatccctg ccttcctgga acagtgatgt gtccccttct tcatggaaca 180
gccaactatc tccagatcca gacagtgccc aagtctcacc atgccctgtg agtgcacaag 240
tatctccata ttcctcagac agtgaaatat cactgtattc acatgaagaa gaagcctctt 300
tctatggaat ggactttaat acatcatcat cccctggaga caatggattg ctacacaggg 360
acacaacctc atactccaga ggaatggagg ccatgtcggc cagcactcca gcaacatcac 420
ctgtgaaagg ggcacaacct gttgattccg cctacagcac tagcactgac tcaggctatg 480
aaagtgaaac gagtcgatcc aactctacag cccctgaagg agatgcctcc gtatctctga 540
gtcccaatga tacctcagat gaagagggca agatgggccg aaggttgagg acggctttca 600
ccagtgatca gatctccact ctggagaaga cttttcagaa acacagatac cttggggcgt 660
ctgaaagacg gaaactcgca gccaaactcc agctttctga agtccagatt aaaacttggt 720
tccagaaccg caggatgaaa tacaaacggg aaatccaaga tggcagacca gactcatacc 780
acccagccca gttctttggt gtgtacggct atgcacagca gcccactcct gtattccagc 840
atgcagtcca acatccctac ccaggttata acccactaat ggaaaccctg cctggtacca 900
tgccctatac catgcatcca cctgccatgg actctctgac tcccttcaac tctcaacctt 960
ttcagatgct ctacctgccc caacagcacc ttgggcaacc tctggcctat taggaagaaa 1020
ggccatttgt tagatattaa tctagaactt ataaaaggac tatactaaag gctggacttt 1080
tccatggact tctgtcctcc cgcaggacaa acaaaattgc actgaatatt gttattgaca 1140
agatgtttac tgaatggatg gctaatattg ggccatgtgt tgacatgatt ttattcacat 1200
tgaatagtgg cgtgtatatt ctatgaaaaa taccatttat atgactaata aatgtaagtt 1260
atatttaaaa aaaaaaaaaa a                                           1281

<210> 11
<211> 271
<212> PRT
<213> Homo sapiens

<400> 11
Pro Asp Pro Asp Ser Ala Gln Val Ser Pro Cys Pro Ala Ser Ala Gln
 1               5                  10                  15      
Val Ser Pro Tyr Ser Ser Asp Ser Glu Ile Ser Leu Tyr Ser His Glu
            20                  25                  30          
Glu Glu Ala Ser Phe Tyr Gly Met Asp Leu Asn Thr Ser Ser Ser Pro
        35                  40                  45              
Gly Asp Asn Gly Leu Leu His Ser Glu Met Val Ser Val Pro Asp Asn
    50                  55                  60                  
Ile Pro Arg Ala Ser Ser Asp Glu Asp Ala Ala Lys Ser Ala Tyr Ser
65                  70                  75                  80  
Thr Ser Thr Asp Ser Gly Tyr Glu Ser Glu Thr Ser Cys Ser Ser Ser
                85                  90                  95      
Thr Ala Pro Glu Gly Asp Ala Ile Ser Leu Ser Pro Asn Asp Thr Ser
            100                 105                 110         
Asp Glu Glu Gly Lys Met Gly Arg Arg Leu Arg Thr Ala Phe Thr Ser
        115                 120                 125             
Asp Gln Ile Ser Thr Leu Glu Lys Thr Phe Gln Lys His Arg Tyr Leu
    130                 135                 140                 
Gly Ala Ser Glu Arg Gln Lys Leu Ala Ala Lys Leu Gln Leu Ser Glu
145                 150                 155                 160 
Val Gln Ile Lys Thr Trp Phe Gln Asn Arg Arg Met Lys Tyr Lys Arg
                165                 170                 175     
Glu Ile Gln Asp Gly Arg Pro Asp Ser Tyr His Pro Ala Gln Phe Phe
            180                 185                 190         
Gly Val Tyr Gly Tyr Ala Gln Gln Pro Thr Pro Val Phe Gln His Ala
        195                 200                 205             
Val Gln His Pro Tyr Pro Gly Tyr Asn Pro Leu Met Glu Thr Leu Pro
    210                 215                 220                 
Gly Thr Met Pro Tyr Thr Met His Pro Pro Ala Met Asp Ser Met Thr
225                 230                 235                 240 
Pro Phe Asn Ser Gln Pro Phe Gln Met Leu Tyr Leu Pro Gln Gln His
                245                 250                 255     
Leu Gly Gln Pro Leu Thr Tyr Gln Glu Glu Arg Pro Phe Val Arg
            260                 265                 270     


<210> 12
<211> 151
<212> PRT
<213> Homo sapiens

<220> 
<223> mutation from homo

<400> 12
Arg Leu Arg Thr Ala Phe Thr Ser Asp Gln Ile Ser Thr Leu Glu Lys
 1               5                  10                  15      
Thr Phe Gln Lys His Arg Tyr Leu Gly Ala Ser Glu Arg Gln Lys Leu
            20                  25                  30          
Ala Ala Lys Leu Gln Leu Ser Glu Val Gln Ile Lys Thr Trp Phe Gln
        35                  40                  45              
Asn Arg Arg Met Lys Tyr Lys Arg Glu Ile Gln Asp Gly Arg Pro Asp
    50                  55                  60                  
Ser Tyr His Pro Ala Gln Phe Phe Gly Val Tyr Gly Tyr Ala Gln Gln
65                  70                  75                  80  
Pro Thr Pro Val Phe Gln His Ala Val Gln His Pro Tyr Pro Gly Tyr
                85                  90                  95      
Asn Pro Leu Met Glu Thr Leu Pro Gly Thr Met Pro Tyr Thr Met His
            100                 105                 110         
Pro Pro Ala Met Asp Ser Met Thr Pro Phe Asn Ser Gln Pro Phe Gln
        115                 120                 125             
Met Leu Tyr Leu Pro Gln Gln His Leu Gly Gln Pro Leu Thr Tyr Gln
    130                 135                 140                 
Glu Glu Arg Pro Phe Val Arg
145                 150     


<210> 13
<211> 181
<212> PRT
<213> Homo sapiens

<400> 13
Met Thr Lys Ala Phe Ser Ser Val Glu Trp Leu Ala Gln Ser Ser Arg
 1               5                  10                  15      
Arg Ser His Arg Glu Gln Pro Ser Lys Val Asp Gln Arg Tyr Ser Pro
            20                  25                  30          
Tyr Pro Ser Pro Ser Leu Pro Ser Trp Asn Ser Asp Val Ser Pro Ser
        35                  40                  45              
Ser Trp Asn Ser Gln Leu Ser Pro Asp Pro Asp Ser Ala Gln Val Ser
    50                  55                  60                  
Pro Cys Pro Ala Ser Ala Gln Val Ser Pro Tyr Ser Ser Asp Ser Glu
65                  70                  75                  80  
Ile Ser Leu Tyr Ser His Glu Glu Glu Ala Ser Phe Tyr Gly Met Asp
                85                  90                  95      
Leu Asn Thr Ser Ser Ser Pro Gly Asp Asn Gly Leu Leu His Ser Glu
            100                 105                 110         
Met Val Ser Val Pro Asp Asn Ile Pro Arg Ala Ser Ser Asp Glu Asp
        115                 120                 125             
Ala Ala Lys Ser Ala Tyr Ser Thr Ser Thr Asp Ser Gly Tyr Glu Ser
    130                 135                 140                 
Glu Thr Ser Cys Ser Ser Ser Thr Ala Pro Glu Gly Asp Ala Ile Ser
145                 150                 155                 160 
Leu Ser Pro Asn Asp Thr Ser Asp Glu Glu Gly Lys Met Gly Arg Arg
                165                 170                 175     
Leu Arg Thr Ala Phe
            180     


<210> 14
<211> 241
<212> PRT
<213> Homo sapiens

<400> 14
Met Thr Lys Ala Phe Ser Ser Val Glu Trp Leu Ala Gln Ser Ser Arg
 1               5                  10                  15      
Arg Ser His Arg Glu Gln Pro Ser Lys Val Asp Gln Arg Tyr Ser Pro
            20                  25                  30          
Tyr Pro Ser Pro Ser Leu Pro Ser Trp Asn Ser Asp Val Ser Pro Ser
        35                  40                  45              
Ser Trp Asn Ser Gln Leu Ser Pro Asp Pro Asp Ser Ala Gln Val Ser
    50                  55                  60                  
Pro Cys Pro Ala Ser Ala Gln Val Ser Pro Tyr Ser Ser Asp Ser Glu
65                  70                  75                  80  
Ile Ser Leu Tyr Ser His Glu Glu Glu Ala Ser Phe Tyr Gly Met Asp
                85                  90                  95      
Leu Asn Thr Ser Ser Ser Pro Gly Asp Asn Gly Leu Leu His Ser Glu
            100                 105                 110         
Met Val Ser Val Pro Asp Asn Ile Pro Arg Ala Ser Ser Asp Glu Asp
        115                 120                 125             
Ala Ala Lys Ser Ala Tyr Ser Thr Ser Thr Asp Ser Gly Tyr Glu Ser
    130                 135                 140                 
Glu Thr Ser Cys Ser Ser Ser Thr Ala Pro Glu Gly Asp Ala Ile Ser
145                 150                 155                 160 
Leu Ser Pro Asn Asp Thr Ser Asp Glu Glu Gly Lys Met Gly Arg Arg
                165                 170                 175     
Leu Arg Thr Ala Phe Thr Ser Asp Gln Ile Ser Thr Leu Glu Lys Thr
            180                 185                 190         
Phe Gln Lys His Arg Tyr Leu Gly Ala Ser Glu Arg Gln Lys Leu Ala
        195                 200                 205             
Ala Lys Leu Gln Leu Ser Glu Val Gln Ile Lys Thr Trp Phe Gln Asn
    210                 215                 220                 
Arg Arg Met Lys Tyr Lys Arg Glu Ile Gln Asp Gly Arg Pro Asp Ser
225                 230                 235                 240 
Tyr
    


<210> 15
<211> 216
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetically generated peptide

<400> 15
Met Thr Lys Ala Phe Ser Ser Val Glu Trp Leu Ala Gln Ser Ser Arg
 1               5                  10                  15      
Arg Ser His Arg Glu Gln Pro Ser Lys Val Asp Gln Arg Tyr Ser Pro
            20                  25                  30          
Tyr Pro Ser Pro Ser Leu Pro Ser Trp Asn Ser Asp Val Ser Pro Ser
        35                  40                  45              
Ser Trp Asn Ser Gln Leu Ser Pro Asp Pro Asp Ser Ala Gln Val Ser
    50                  55                  60                  
Pro Cys Pro Ala Ser Ala Gln Val Ser Pro Tyr Ser Ser Asp Ser Glu
65                  70                  75                  80  
Ile Ser Leu Tyr Ser His Glu Glu Glu Ala Ser Phe Tyr Gly Met Asp
                85                  90                  95      
Leu Asn Thr Ser Ser Ser Pro Gly Asp Asn Gly Leu Leu His Ser Glu
            100                 105                 110         
Met Val Ser Val Pro Asp Asn Ile Pro Arg Ala Ser Ser Asp Glu Asp
        115                 120                 125             
Ala Ala Tyr His Pro Ala Gln Phe Phe Gly Val Tyr Gly Tyr Ala Gln
    130                 135                 140                 
Gln Pro Thr Pro Val Phe Gln His Ala Val Gln His Pro Tyr Pro Gly
145                 150                 155                 160 
Tyr Asn Pro Leu Met Glu Thr Leu Pro Gly Thr Met Pro Tyr Thr Met
                165                 170                 175     
His Pro Pro Ala Met Asp Ser Met Thr Pro Phe Asn Ser Gln Pro Phe
            180                 185                 190         
Gln Met Leu Tyr Leu Pro Gln Gln His Leu Gly Gln Pro Leu Thr Tyr
        195                 200                 205             
Gln Glu Glu Arg Pro Phe Val Arg
    210                 215     


<210> 16
<211> 341
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetically generated peptide

<400> 16
Met Thr Lys Ala Phe Ser Ser Val Glu Trp Leu Ala Gln Ser Ser Arg
 1               5                  10                  15      
Arg Ser His Arg Glu Gln Pro Ser Lys Val Asp Gln Arg Tyr Ser Pro
            20                  25                  30          
Tyr Pro Ser Pro Ser Leu Pro Ser Trp Asn Ser Asp Val Ser Pro Ser
        35                  40                  45              
Ser Trp Asn Ser Gln Leu Ser Pro Asp Pro Asp Ser Ala Gln Val Ser
    50                  55                  60                  
Pro Cys Pro Ala Ser Ala Gln Val Ser Pro Tyr Ser Ser Asp Ser Glu
65                  70                  75                  80  
Ile Ser Leu Tyr Ser His Glu Glu Glu Ala Ser Phe Tyr Gly Met Asp
                85                  90                  95      
Leu Asn Thr Ser Ser Ser Pro Gly Asp Asn Gly Leu Leu His Ser Glu
            100                 105                 110         
Met Val Ser Val Pro Asp Asn Ile Pro Arg Ala Ser Ser Asp Glu Asp
        115                 120                 125             
Ala Ala Lys Ser Ala Tyr Ser Thr Ser Thr Asp Ser Gly Tyr Glu Ser
    130                 135                 140                 
Glu Thr Ser Cys Ser Ser Ser Thr Ala Pro Glu Gly Asp Ala Ile Ser
145                 150                 155                 160 
Leu Ser Pro Asn Asp Thr Ser Asp Glu Glu Gly Lys Met Gly Arg Arg
                165                 170                 175     
Val Arg Thr Ala Phe Thr Met Glu Gln Val Arg Thr Leu Glu Gly Val
            180                 185                 190         
Phe Gln His His Gln Tyr Leu Ser Pro Leu Glu Arg Lys Arg Leu Ala
        195                 200                 205             
Arg Glu Met Gln Leu Ser Glu Val Gln Ile Lys Thr Trp Phe Gln Asn
    210                 215                 220                 
Arg Arg Met Lys His Lys Arg Gln Met Gln Asp Pro Gln Leu His Ser
225                 230                 235                 240 
Pro Phe Ser Gly Ser Leu His Ala Pro Pro Ala Phe Tyr Ser Thr Ser
                245                 250                 255     
Ser Gly Leu Ala Asn Gly Leu Gln Leu Leu Cys Pro Trp Ala Pro Leu
            260                 265                 270         
Ser Gly Pro Gln Ala Leu Met Leu Pro Pro Gly Ser Phe Trp Gly Leu
        275                 280                 285             
Cys Gln Val Ala Gln Glu Ala Leu Ala Ser Ala Gly Ala Ser Cys Cys
    290                 295                 300                 
Gly Gln Pro Leu Ala Ser His Pro Pro Thr Pro Gly Arg Pro Ser Leu
305                 310                 315                 320 
Gly Pro Ala Leu Ser Thr Gly Pro Arg Gly Leu Cys Ala Met Pro Gln
                325                 330                 335     
Thr Gly Asp Ala Phe
            340     






