                         SEQUENCE LISTING

<110>  Kroenke, Martin
       Krut, Oleg
       Kroenke-Wiegmann, Katja
       Hoppe, Uta
 
<120>  Neutral Sphingomyelinase-3 and its Use

<130>  070245wo

<150>  EP 06101431.2
<151>  2006-02-08

<160>  33    

<170>  PatentIn version 3.3

<210>  1
<211>  4896
<212>  DNA
<213>  Homo sapiens

<400>  1
gggcagagac acggccgcag ggtcctgggg ctcgctcgct agcctctgcc cggcacacat     60

ggacttgagc atctggaaga cggcgagggg ggccacgttc agcttcagca ggtccaccag    120

gatcctggcg gggacagacg cggggccggt gagccctctc cgcccggcgc ggccacctcc    180

ctgaagaccc gacaaggacg ggggcggggg ctcctcccga ccagcgggcc gggcgtaccc    240

ggaaagcaga ggtcgggggg tgtctggcta gcatgcggcc cccacccgcc ccgctcactt    300

gaacacgtcg gggtcgatag cgccgcccgc cgcctgcgcc agctcgtaca gctccatctc    360

ctcggtgctc agcaccttct tccgccgcag cgccagcttc tgccgggccg cctccagccc    420

cgggggcgcc gccgaccccg gcccaggccc tacgccctgc gccgccatcc ccgcggcccg    480

cggaaaggtg cgctccgccc cgccgcgccc cctagcggct gcgcccacca ccctctccct    540

gcagcgtcaa cgtctggcct cccgggctgc cctggcggga ggggcgggag cgcggggacg    600

gggccgcctc cgcggcgtca ttgaagccca acagttattg ggcgctcacg gtgtgctgag    660

cggcgctcta ggagccggga gtggcatggc ggaccgcagg ggtccgctgc ttggcgatct    720


gggcctccct gatagactgc attggtcgtg ctcgcttagg tggcagcacc cagcccagtg    780

ccaggcatac attgggcgct cggtaaatgc ctctttcaag aaagcgtgca attttctggt    840

ccgcaccggt gcaccactag gggtcgcttt tcggggcggg cggggggaag gggggggcac    900

taatcaacaa tactgcttac gcgcacgcgg attccttgct ggggagaaag taccttgggg    960

cgccggaggc cgccacaacg caggcgcatt cagctaagga ccactccctc ccccgcactc   1020

ctgcctcgcc atttctcttc cccgcccggc cggccttcgc tttgcgcacg cgccttttga   1080

ggtaacggcc caaagaggtg gaagcgcttt tcccgcccgg ccgcggggcg tggctctgcg   1140

cgcagcttga tgacgacttt cggcgccgtg gcggaatggc ggcttccatc tctgaggcga   1200

gcgacgctat ggatcccaca gtggtttgct aagaaggcca ttttcaactc tccactggag   1260

gctgctatgg cgttccctca cctgcagcag cccagctttc tactggctag cctgaaagct   1320

gactctataa ataagccctt tgcacagcag tgccaagact tggttaaagt cattgaggac   1380

tttccagcaa aggagctgca caccatcttc ccatggctgg tagaaagcat ttttggcagc   1440

ctagatggtg tcctcgttgg ctggaacctc cgctgcttac aggggcgcgt gaatcctgtg   1500

gagtacagca tcgtgatgga atttctcgac cctggtggcc caatgatgaa gttggtttat   1560

aagcttcaag ctgaagacta taagttcgac tttcctgtct cctacttgcc tggtcctgtg   1620

aaggcgtcca tccaggagtg catcctccct gacagtcctc tgtaccacaa caaggtccag   1680

ttcaccccta ctgggggcct tggtctgaac ttggccctga atccgttcga gtattacata   1740

ttcttctttg ccttgagcct catcactcag aagccacttc ctgtgtccct ccacgtccgt   1800

acttcagact gtgcctattt catcctggtg gacaggtacc tgtcatggtt cctgcccacc   1860

gaaggcagtg tgcccccacc actctcctcc agcccagggg ggaccagccc ctcaccacct   1920

cccaggacac cagccatacc ctttgcttcc tatggcctcc accacactag cctcctaaag   1980

cgacacatct ctcatcagac gtctgtgaat gcagaccccg cctcccacga gatctggagg   2040

tcagaaactc tgctccaggt ttttgttgaa atgtggcttc atcactattc cttggagatg   2100

tatcaaaaaa tgcagtcccc tcatgccaag ctggaggttc tgcactaccg actcagtgtc   2160

tccagcgccc tctacagccc cgcccaaccc agcctccagg ccctccacgc ctaccaagag   2220

tcgttcacgc ctactgagga gcatgtgttg gtggtgcgcc tgctgctgaa gcacctgcac   2280

gcctttgcca acagcctgaa gccagagcag gcctcaccct ccgcccactc ccacgccacc   2340

agccccctgg aggagttcaa acgggctgct gtcccgaggt tcgtccagca gaaactctac   2400

ctcttcttgc agcattgctt tggccactgg cccctggacg catcgttcag agctgtcctg   2460

gagatgtggc tgagctacct gcagccgtgg cggtacgcgc ctgacaagca ggctccgggc   2520

agcgactccc agccccggtg tgtgtcggag aaatgggcac cctttgtcca ggagaacctg   2580

ctgatgtaca ccaagttgtt tgtgggcttt ctgaaccgcg cgctccgcac agacctggtc   2640

agccccaagc acgcgctcat ggtgttccga gtggccaaag tctttgccca gcccaacctg   2700

gctgagatga ttcagaaagg tgagcagcta ttcctggagc cagagctggt catcccccac   2760

cgccagcacc gactcttcac ggcccccaca ttcactggga gcttcctgtc accctggcca   2820

ccagcggtca ctgatgcctc cttcaaggtg aagagccacg tctacagcct ggagggccag   2880

gactgcaagt acaccccgat gtttgggccc gaggcccgca ccctggtcct gcgcctcgct   2940

cagctcatca cacaggccaa acacacagcc aagtccatct ccgaccagtg tgcggagagc   3000

ccggctggcc actccttcct ctcatggctg ggctttagct ccatggacac caatggctcc   3060

tacacagcca acgacctgga cgagatgggg caagacagtg tccggaagac agatgaatac   3120

ctggagaagg ccctggagta cctgcgccag atattccggc tcagcgaagc gcagctcagg   3180

cagttcacac tcgccttggg caccacccag gatgagaatg gaaaaaagca actccccgac   3240

tgcatcgtgg gtgaggacgg actcatcctt acgcccctgg ggcggtacca gatcatcaat   3300

gggctgcgaa ggtttgaaat tgagtaccag ggggacccgg agctgcagcc catccggagc   3360

tatgagatcg ccagcttggt ccgcacactc tttaggctgt cgtctgccat caaccacaga   3420

tttgcaggac agatggcggc tctgtgttcc cgggatgact tcctcggcag cttctgtcgc   3480

taccacctca cagaacctgg gctggccagc aggcacctgc tgagccctgt ggggcggagg   3540

caggtggccg gccacacccg cggccccagg ctcagcctgc gcttcctggg cagttaccgg   3600

acgctggtct cgctgctgct ggccttcttc gtggcctctc tgttctgcgt cgggcccctc   3660

ccatgcacgc tgctgctcac cctgggctat gtcctctacg cctctgccat gacactgctg   3720

accgagcggg ggaagctgca ccagccctga aggtgtcagc tgccttcaga gcaggctgga   3780

gggatttgcc acacagcccc acccttgggc tgagaggacc tgggaagccc ctccaggagg   3840

gaacacggtc atcctcgggc ttctggagcg gggttcctgc agccgcagag gcatctggag   3900

gaaacgcaac caagaaagga aggcaggtgg gccccagcaa aggagtagct gccagggctc   3960

aacagctacg ctctgtgaca gcgcagagct cagcggcggc ctttccctcc ctccgccaag   4020

gactcacggc caagccagct ctcggggcct tttttccact gcccatttgg ctactctgct   4080

gcaccaagct tgggagccag cctgccaaca gccacctggg cctggcctcc ccactggctg   4140

gccttgaggt tggcagagtg ggttgtggcg cttcctctct ctgtgtggga ccaggacagt   4200

ggcttaagtc tccactccag gaaagaatca aagtttctag agttgtgaga aaaccagaga   4260

gtggctgtcc tgattcttca ctgtgagggg cgttcttcat gttctcccag ctgttccaag   4320

actgggccgt agaattccat gtttcaggag cctaagaccc tcccagagcc caggggcttc   4380

accgcagacc ccaagccatt gagcacatca cccaaagcag tggccaacat cgcggacccc   4440

tgtgccttgt cacagatggg tgctggtcct caggcgttgg ggacactgct gggtcgatgg   4500

ggtcggattc tgccagtttc tgctctgcag ccaaagatgg tcagaagcat tgtcacttca   4560


gtaacatcaa gtgctcaaag acatggcaac cgttcagtgg tacttaagta ttcaaaatat   4620

acaactacag attctctgac agaaaccagc acggggtctt caccttcatt caccccacag   4680

gcgacatgcg agggagaaca gcatctcagt ggtgatttcc aaaccaagcc tttgttttcg   4740

gtgtggggtt ttgggggttt gctttaatgt ttttgaaatt gtaaatgttg ggctttgtat   4800

tttgatgtaa actgagcata atggcatttt agggcctgtg accaaaaatg aagcttgtaa   4860

cgaccatgga tctgaataaa catgtccttg cttctg                             4896


<210>  2
<211>  2598
<212>  DNA
<213>  Homo sapiens

<400>  2
atgacgactt tcggcgccgt ggcggaatgg cggcttccat ctctgaggcg agcgacgcta     60

tggatcccac agtggtttgc taagaaggcc attttcaact ctccactgga ggctgctatg    120

gcgttccctc acctgcagca gcccagcttt ctactggcta gcctgaaagc tgactctata    180

aataagccct ttgcacagca gtgccaagac ttggttaaag tcattgagga ctttccagca    240

aaggagctgc acaccatctt cccatggctg gtagaaagca tttttggcag cctagatggt    300

gtcctcgttg gctggaacct ccgctgctta caggggcgcg tgaatcctgt ggagtacagc    360

atcgtgatgg aatttctcga ccctggtggc ccaatgatga agttggttta taagcttcaa    420

gctgaagact ataagttcga ctttcctgtc tcctacttgc ctggtcctgt gaaggcgtcc    480

atccaggagt gcatcctccc tgacagtcct ctgtaccaca acaaggtcca gttcacccct    540

actgggggcc ttggtctgaa cttggccctg aatccgttcg agtattacat attcttcttt    600

gccttgagcc tcatcactca gaagccactt cctgtgtccc tccacgtccg tacttcagac    660

tgtgcctatt tcatcctggt ggacaggtac ctgtcatggt tcctgcccac cgaaggcagt    720

gtgcccccac cactctcctc cagcccaggg gggaccagcc cctcaccacc tcccaggaca    780

ccagccatac cctttgcttc ctatggcctc caccacacta gcctcctaaa gcgacacatc    840

tctcatcaga cgtctgtgaa tgcagacccc gcctcccacg agatctggag gtcagaaact    900

ctgctccagg tttttgttga aatgtggctt catcactatt ccttggagat gtatcaaaaa    960

atgcagtccc ctcatgccaa gctggaggtt ctgcactacc gactcagtgt ctccagcgcc   1020

ctctacagcc ccgcccaacc cagcctccag gccctccacg cctaccaaga gtcgttcacg   1080

cctactgagg agcatgtgtt ggtggtgcgc ctgctgctga agcacctgca cgcctttgcc   1140

aacagcctga agccagagca ggcctcaccc tccgcccact cccacgccac cagccccctg   1200

gaggagttca aacgggctgc tgtcccgagg ttcgtccagc agaaactcta cctcttcttg   1260

cagcattgct ttggccactg gcccctggac gcatcgttca gagctgtcct ggagatgtgg   1320

ctgagctacc tgcagccgtg gcggtacgcg cctgacaagc aggctccggg cagcgactcc   1380

cagccccggt gtgtgtcgga gaaatgggca ccctttgtcc aggagaacct gctgatgtac   1440

accaagttgt ttgtgggctt tctgaaccgc gcgctccgca cagacctggt cagccccaag   1500

cacgcgctca tggtgttccg agtggccaaa gtctttgccc agcccaacct ggctgagatg   1560

attcagaaag gtgagcagct attcctggag ccagagctgg tcatccccca ccgccagcac   1620

cgactcttca cggcccccac attcactggg agcttcctgt caccctggcc accagcggtc   1680

actgatgcct ccttcaaggt gaagagccac gtctacagcc tggagggcca ggactgcaag   1740

tacaccccga tgtttgggcc cgaggcccgc accctggtcc tgcgcctcgc tcagctcatc   1800

acacaggcca aacacacagc caagtccatc tccgaccagt gtgcggagag cccggctggc   1860

cactccttcc tctcatggct gggctttagc tccatggaca ccaatggctc ctacacagcc   1920

aacgacctgg acgagatggg gcaagacagt gtccggaaga cagatgaata cctggagaag   1980

gccctggagt acctgcgcca gatattccgg ctcagcgaag cgcagctcag gcagttcaca   2040

ctcgccttgg gcaccaccca ggatgagaat ggaaaaaagc aactccccga ctgcatcgtg   2100

ggtgaggacg gactcatcct tacgcccctg gggcggtacc agatcatcaa tgggctgcga   2160

aggtttgaaa ttgagtacca gggggacccg gagctgcagc ccatccggag ctatgagatc   2220

gccagcttgg tccgcacact ctttaggctg tcgtctgcca tcaaccacag atttgcagga   2280

cagatggcgg ctctgtgttc ccgggatgac ttcctcggca gcttctgtcg ctaccacctc   2340

acagaacctg ggctggccag caggcacctg ctgagccctg tggggcggag gcaggtggcc   2400

ggccacaccc gcggccccag gctcagcctg cgcttcctgg gcagttaccg gacgctggtc   2460

tcgctgctgc tggccttctt cgtggcctct ctgttctgcg tcgggcccct cccatgcacg   2520

ctgctgctca ccctgggcta tgtcctctac gcctctgcca tgacactgct gaccgagcgg   2580

gggaagctgc accagccc                                                 2598


<210>  3
<211>  866
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Thr Thr Phe Gly Ala Val Ala Glu Trp Arg Leu Pro Ser Leu Arg 
1               5                   10                  15      


Arg Ala Thr Leu Trp Ile Pro Gln Trp Phe Ala Lys Lys Ala Ile Phe 
            20                  25                  30          


Asn Ser Pro Leu Glu Ala Ala Met Ala Phe Pro His Leu Gln Gln Pro 
        35                  40                  45              


Ser Phe Leu Leu Ala Ser Leu Lys Ala Asp Ser Ile Asn Lys Pro Phe 
    50                  55                  60                  


Ala Gln Gln Cys Gln Asp Leu Val Lys Val Ile Glu Asp Phe Pro Ala 
65                  70                  75                  80  


Lys Glu Leu His Thr Ile Phe Pro Trp Leu Val Glu Ser Ile Phe Gly 
                85                  90                  95      


Ser Leu Asp Gly Val Leu Val Gly Trp Asn Leu Arg Cys Leu Gln Gly 
            100                 105                 110         


Arg Val Asn Pro Val Glu Tyr Ser Ile Val Met Glu Phe Leu Asp Pro 
        115                 120                 125             


Gly Gly Pro Met Met Lys Leu Val Tyr Lys Leu Gln Ala Glu Asp Tyr 
    130                 135                 140                 


Lys Phe Asp Phe Pro Val Ser Tyr Leu Pro Gly Pro Val Lys Ala Ser 
145                 150                 155                 160 


Ile Gln Glu Cys Ile Leu Pro Asp Ser Pro Leu Tyr His Asn Lys Val 
                165                 170                 175     


Gln Phe Thr Pro Thr Gly Gly Leu Gly Leu Asn Leu Ala Leu Asn Pro 
            180                 185                 190         


Phe Glu Tyr Tyr Ile Phe Phe Phe Ala Leu Ser Leu Ile Thr Gln Lys 
        195                 200                 205             


Pro Leu Pro Val Ser Leu His Val Arg Thr Ser Asp Cys Ala Tyr Phe 
    210                 215                 220                 


Ile Leu Val Asp Arg Tyr Leu Ser Trp Phe Leu Pro Thr Glu Gly Ser 
225                 230                 235                 240 


Val Pro Pro Pro Leu Ser Ser Ser Pro Gly Gly Thr Ser Pro Ser Pro 
                245                 250                 255     


Pro Pro Arg Thr Pro Ala Ile Pro Phe Ala Ser Tyr Gly Leu His His 
            260                 265                 270         


Thr Ser Leu Leu Lys Arg His Ile Ser His Gln Thr Ser Val Asn Ala 
        275                 280                 285             


Asp Pro Ala Ser His Glu Ile Trp Arg Ser Glu Thr Leu Leu Gln Val 
    290                 295                 300                 


Phe Val Glu Met Trp Leu His His Tyr Ser Leu Glu Met Tyr Gln Lys 
305                 310                 315                 320 


Met Gln Ser Pro His Ala Lys Leu Glu Val Leu His Tyr Arg Leu Ser 
                325                 330                 335     


Val Ser Ser Ala Leu Tyr Ser Pro Ala Gln Pro Ser Leu Gln Ala Leu 
            340                 345                 350         


His Ala Tyr Gln Glu Ser Phe Thr Pro Thr Glu Glu His Val Leu Val 
        355                 360                 365             


Val Arg Leu Leu Leu Lys His Leu His Ala Phe Ala Asn Ser Leu Lys 
    370                 375                 380                 


Pro Glu Gln Ala Ser Pro Ser Ala His Ser His Ala Thr Ser Pro Leu 
385                 390                 395                 400 


Glu Glu Phe Lys Arg Ala Ala Val Pro Arg Phe Val Gln Gln Lys Leu 
                405                 410                 415     


Tyr Leu Phe Leu Gln His Cys Phe Gly His Trp Pro Leu Asp Ala Ser 
            420                 425                 430         


Phe Arg Ala Val Leu Glu Met Trp Leu Ser Tyr Leu Gln Pro Trp Arg 
        435                 440                 445             


Tyr Ala Pro Asp Lys Gln Ala Pro Gly Ser Asp Ser Gln Pro Arg Cys 
    450                 455                 460                 


Val Ser Glu Lys Trp Ala Pro Phe Val Gln Glu Asn Leu Leu Met Tyr 
465                 470                 475                 480 


Thr Lys Leu Phe Val Gly Phe Leu Asn Arg Ala Leu Arg Thr Asp Leu 
                485                 490                 495     


Val Ser Pro Lys His Ala Leu Met Val Phe Arg Val Ala Lys Val Phe 
            500                 505                 510         


Ala Gln Pro Asn Leu Ala Glu Met Ile Gln Lys Gly Glu Gln Leu Phe 
        515                 520                 525             


Leu Glu Pro Glu Leu Val Ile Pro His Arg Gln His Arg Leu Phe Thr 
    530                 535                 540                 


Ala Pro Thr Phe Thr Gly Ser Phe Leu Ser Pro Trp Pro Pro Ala Val 
545                 550                 555                 560 


Thr Asp Ala Ser Phe Lys Val Lys Ser His Val Tyr Ser Leu Glu Gly 
                565                 570                 575     


Gln Asp Cys Lys Tyr Thr Pro Met Phe Gly Pro Glu Ala Arg Thr Leu 
            580                 585                 590         


Val Leu Arg Leu Ala Gln Leu Ile Thr Gln Ala Lys His Thr Ala Lys 
        595                 600                 605             


Ser Ile Ser Asp Gln Cys Ala Glu Ser Pro Ala Gly His Ser Phe Leu 
    610                 615                 620                 


Ser Trp Leu Gly Phe Ser Ser Met Asp Thr Asn Gly Ser Tyr Thr Ala 
625                 630                 635                 640 


Asn Asp Leu Asp Glu Met Gly Gln Asp Ser Val Arg Lys Thr Asp Glu 
                645                 650                 655     


Tyr Leu Glu Lys Ala Leu Glu Tyr Leu Arg Gln Ile Phe Arg Leu Ser 
            660                 665                 670         


Glu Ala Gln Leu Arg Gln Phe Thr Leu Ala Leu Gly Thr Thr Gln Asp 
        675                 680                 685             


Glu Asn Gly Lys Lys Gln Leu Pro Asp Cys Ile Val Gly Glu Asp Gly 
    690                 695                 700                 


Leu Ile Leu Thr Pro Leu Gly Arg Tyr Gln Ile Ile Asn Gly Leu Arg 
705                 710                 715                 720 


Arg Phe Glu Ile Glu Tyr Gln Gly Asp Pro Glu Leu Gln Pro Ile Arg 
                725                 730                 735     


Ser Tyr Glu Ile Ala Ser Leu Val Arg Thr Leu Phe Arg Leu Ser Ser 
            740                 745                 750         


Ala Ile Asn His Arg Phe Ala Gly Gln Met Ala Ala Leu Cys Ser Arg 
        755                 760                 765             


Asp Asp Phe Leu Gly Ser Phe Cys Arg Tyr His Leu Thr Glu Pro Gly 
    770                 775                 780                 


Leu Ala Ser Arg His Leu Leu Ser Pro Val Gly Arg Arg Gln Val Ala 
785                 790                 795                 800 


Gly His Thr Arg Gly Pro Arg Leu Ser Leu Arg Phe Leu Gly Ser Tyr 
                805                 810                 815     


Arg Thr Leu Val Ser Leu Leu Leu Ala Phe Phe Val Ala Ser Leu Phe 
            820                 825                 830         


Cys Val Gly Pro Leu Pro Cys Thr Leu Leu Leu Thr Leu Gly Tyr Val 
        835                 840                 845             


Leu Tyr Ala Ser Ala Met Thr Leu Leu Thr Glu Arg Gly Lys Leu His 
    850                 855                 860                 


Gln Pro 
865     


<210>  4
<211>  827
<212>  PRT
<213>  Canis familiaris

<400>  4

Met Ala Phe Pro His Leu Gln Gln Pro Ser Phe Leu Leu Ala Ser Leu 
1               5                   10                  15      


Lys Ala Asp Ser Ile Asn Lys Pro Phe Ala Gln Arg Cys Gln Asp Leu 
            20                  25                  30          


Val Lys Val Ile Glu Asp Phe Pro Ala Lys Glu Leu His Thr Ile Phe 
        35                  40                  45              


Pro Trp Leu Val Glu Ser Ile Phe Gly Ser Leu Asp Gly Val Leu Val 
    50                  55                  60                  


Gly Trp Asn Leu Arg Cys Leu Gln Gly Arg Val Asn Pro Met Glu Tyr 
65                  70                  75                  80  


Ser Ile Ala Met Glu Phe Leu Asp Pro Gly Gly Pro Met Met Lys Leu 
                85                  90                  95      


Val Tyr Lys Leu Gln Ala Glu Asp Tyr Lys Phe Asp Phe Pro Val Ser 
            100                 105                 110         


Tyr Leu Pro Gly Pro Val Lys Ala Ser Ile Gln Glu Arg Val Leu Pro 
        115                 120                 125             


Asp Ser Pro Leu Tyr His Asn Lys Val Gln Phe Pro Ala Thr Gly Gly 
    130                 135                 140                 


Leu Gly Leu Asn Leu Ala Leu Asn Pro Phe Glu Tyr Tyr Met Phe Phe 
145                 150                 155                 160 


Phe Ala Leu Ser Leu Ile Thr Gln Lys Pro Leu Pro Gly Ala Leu His 
                165                 170                 175     


Ile Arg Thr Ser Asp Cys Ala Tyr Phe Ile Leu Val Asp Arg Tyr Leu 
            180                 185                 190         


Ser Trp Phe Leu Pro Thr Glu Gly Ser Val Leu Pro Pro Leu Ser Ser 
        195                 200                 205             


Ser Pro Gly Gly Pro Ser Pro Ser Pro Ala Pro Arg Thr Pro Ala Ile 
    210                 215                 220                 


Pro Phe Ala Ser Tyr Gly Leu His His Thr Ser Leu Leu Lys Arg His 
225                 230                 235                 240 


Val Ser His Gln Thr Ser Val Asn Ala Asp Pro Ala Ser His Glu Ile 
                245                 250                 255     


Trp Arg Ser Glu Thr Leu Leu Gln Val Phe Val Glu Met Trp Leu His 
            260                 265                 270         


His Tyr Ser Leu Glu Met Tyr Gln Lys Met Gln Ser Pro His Ala Lys 
        275                 280                 285             


Leu Glu Val Leu His Tyr Arg Leu Ser Val Ser Ser Ala Leu His Ser 
    290                 295                 300                 


Pro Ala Gln Pro Ser Leu Gln Ala Leu His Ala Tyr Gln Glu Ser Phe 
305                 310                 315                 320 


Thr Pro Thr Glu Glu His Val Leu Val Val Arg Leu Leu Leu Lys His 
                325                 330                 335     


Leu His Ala Phe Ser Asn Ser Leu Lys Pro Glu Gln Val Ser Pro Ser 
            340                 345                 350         


Ala His Ser His Ala Thr Ser Pro Leu Glu Glu Phe Lys Arg Ala Ala 
        355                 360                 365             


Val Pro Arg Phe Val Gln Gln Lys Leu Tyr Leu Phe Leu Gln His Cys 
    370                 375                 380                 


Phe Gly His Trp Pro Leu Asp Ala Ser Phe Arg Ala Val Leu Glu Met 
385                 390                 395                 400 


Trp Leu Ser Tyr Leu Gln Pro Trp Arg Tyr Ala Pro Glu Lys Pro Ala 

                405                 410                 415     


Pro Ser Ser Asp Cys Gln Ala Arg Cys Val Ser Glu Arg Trp Ala Pro 
            420                 425                 430         


Phe Val Gln Glu Asn Leu Leu Met Tyr Thr Lys Leu Phe Val Gly Phe 
        435                 440                 445             


Leu Ser Arg Ala Leu Arg Thr Asp Leu Val Ser Pro Lys Asn Ala Leu 
    450                 455                 460                 


Met Val Phe Arg Val Ala Lys Val Phe Ala Gln Pro Asn Leu Ala Glu 
465                 470                 475                 480 


Met Ile Gln Lys Gly Glu Gln Leu Phe Leu Glu Pro Glu Leu Val Ile 
                485                 490                 495     


Pro His Arg Gln His Arg Leu Phe Thr Ala Pro Thr Phe Thr Gly Ser 
            500                 505                 510         


Phe Leu Ser Ser Trp Pro Pro Ala Val Thr Asp Thr Ser Phe Arg Val 
        515                 520                 525             


Lys Ser His Val Tyr Ser Leu Glu Gly Gln Asp Cys Lys Tyr Thr Pro 
    530                 535                 540                 


Met Phe Gly Pro Glu Val Arg Thr Leu Val Leu Arg Leu Ala Gln Leu 
545                 550                 555                 560 


Ile Thr Gln Ala Lys Gln Thr Ala Lys Ser Ile Ser Asp Gln Cys Gly 
                565                 570                 575     


Glu Ser Thr Pro Gly His Pro Phe Leu Ser Trp Leu Gly Phe Cys Ser 
            580                 585                 590         


Thr Asp Thr Asn Gly Ser Tyr Pro Ala Asn Asp Leu Asp Glu Met Gly 
        595                 600                 605             


Gln Asp Ser Val Arg Lys Thr Asp Glu Tyr Leu Glu Lys Ala Leu Glu 
    610                 615                 620                 


Tyr Leu Cys Gln Met Phe Arg Leu Ser Glu Ala Gln Leu Ala Gln Leu 
625                 630                 635                 640 


Thr Leu Ala Leu Gly Thr Thr Gln Asp Glu Asn Gly Lys Lys Gln Leu 
                645                 650                 655     


Pro Asp Cys Ile Val Gly Glu Asp Gly Leu Ile Leu Thr Pro Leu Gly 
            660                 665                 670         


Arg Tyr Gln Ile Ile Asn Gly Leu Arg Lys Phe Asp Ile Glu Tyr Gln 
        675                 680                 685             


Gly Asp Leu Glu Leu Gln Pro Ile Arg Ser Tyr Glu Ile Ala Ser Leu 
    690                 695                 700                 


Val Arg Met Leu Phe Arg Leu Ser Ser Ala Ile Asn Cys Arg Phe Ala 
705                 710                 715                 720 


Gly Gln Met Ala Ala Leu Cys Ser Arg Ala Asp Phe Leu Gly Ser Phe 
                725                 730                 735     


Cys Arg Tyr His Leu Thr Glu Pro Gly Val Thr Gly Arg His Leu Leu 
            740                 745                 750         


Ser Pro Val Ala Arg Glu Ser Ala Ala Ser Arg Ala Arg Gly Pro Arg 
        755                 760                 765             


Leu Ser Leu Arg Phe Leu Gly Ser Tyr Arg Thr Leu Leu Ser Leu Leu 
    770                 775                 780                 


Leu Ala Phe Phe Val Ala Ser Leu Phe Cys Ile Gly Pro Leu Pro Cys 
785                 790                 795                 800 


Ala Leu Leu Leu Met Leu Gly Tyr Leu Leu Tyr Ala Val Ala Met Thr 
                805                 810                 815     


Leu Leu Thr Glu Arg Ser Lys Leu His Gln Leu 
            820                 825         


<210>  5
<211>  823
<212>  PRT
<213>  Mus musculus

<400>  5

Met Ala Phe Pro His Leu Gln Gln Pro Ser Phe Leu Leu Ala Ser Leu 
1               5                   10                  15      


Lys Ala Asp Ser Ile Asn Lys Pro Phe Ala Gln Arg Cys Gln Asp Leu 
            20                  25                  30          


Val Lys Val Ile Glu Asp Phe Pro Ala Lys Glu Leu His Ala Val Phe 
        35                  40                  45              


Pro Trp Leu Val Glu Ser Ile Phe Gly Ser Leu Asp Gly Val Leu Val 
    50                  55                  60                  


Gly Trp Asn Leu Arg Cys Leu Gln Gly Arg Val Asn Pro Val Glu Tyr 
65                  70                  75                  80  


Ser Thr Ala Met Glu Phe Leu Asp Pro Ser Gly Pro Met Met Lys Leu 
                85                  90                  95      


Val Tyr Lys Leu Gln Ala Glu Asp Tyr Asn Phe Asp Phe Pro Val Ser 
            100                 105                 110         


Cys Leu Pro Gly Pro Val Lys Ala Ser Ile Gln Glu Asn Val Leu Pro 
        115                 120                 125             


Asp Ser Pro Leu Tyr His Asn Lys Val Gln Phe Pro Pro Thr Gly Gly 
    130                 135                 140                 


Leu Gly Leu Asn Leu Ala Leu Asn Pro Phe Glu Tyr Tyr Met Phe Tyr 
145                 150                 155                 160 


Phe Ala Leu Ser Leu Ile Ser Gln Lys Pro Met Ser Met Thr Leu His 
                165                 170                 175     


Val Arg Thr Ser Asp Cys Ala Tyr Phe Thr Leu Val Asp Arg Tyr Leu 
            180                 185                 190         


Ser Trp Phe Leu Pro Thr Glu Gly Ser Val Pro Pro Pro Leu Cys Ser 
        195                 200                 205             


Ser Pro Gly Gly Ser Ser Pro Ser Pro Ala Pro Arg Thr Pro Ala Met 
    210                 215                 220                 


Pro Phe Ala Ser Tyr Gly Leu His Thr Ser Leu Leu Lys Arg His Ile 
225                 230                 235                 240 


Ser His Gln Thr Ser Val Asn Ala Asp Pro Ala Ser His Glu Ile Trp 
                245                 250                 255     


Arg Ser Glu Thr Leu Leu Gln Val Phe Val Glu Met Trp Leu His His 
            260                 265                 270         


Tyr Ser Leu Glu Met Tyr Gln Lys Met Gln Ser Pro His Ala Lys Leu 
        275                 280                 285             


Glu Val Leu His Tyr Arg Leu Thr Val Ser Ser Ala Leu His Ser Pro 
    290                 295                 300                 


Ala Gln Pro Ser Leu Gln Ala Leu His Ala Tyr Gln Glu Ser Phe Thr 
305                 310                 315                 320 


Pro Thr Glu Glu His Val Leu Val Val Arg Leu Leu Leu Lys His Leu 
                325                 330                 335     


His Ala Phe Ala Asn Ser Leu Lys Pro Asp Gln Ala Ser Pro Ser Ala 
            340                 345                 350         


His Ser His Ala Thr Ser Pro Leu Glu Glu Phe Lys Arg Ala Ala Glu 
        355                 360                 365             


Pro Arg Phe Val Gln Gln Lys Leu Tyr Val Phe Leu Gln His Cys Phe 
    370                 375                 380                 


Gly His Trp Pro Leu Asp Ala Thr Phe Arg Ala Val Leu Glu Met Trp 
385                 390                 395                 400 


Leu Ser Tyr Leu Gln Pro Trp Arg Tyr Ala Pro Glu Lys Gln Ala Gln 
                405                 410                 415     


Gly Ser Asp Pro Gln Pro Arg Cys Val Ser Glu Lys Trp Ala Pro Phe 
            420                 425                 430         


Ile Gln Glu Asn Leu Leu Met Tyr Thr Lys Leu Phe Val Ser Phe Leu 
        435                 440                 445             


Asn Arg Ala Leu Arg Thr Asp Leu Val Ser Pro Lys Asn Ala Leu Met 
    450                 455                 460                 


Val Phe Arg Val Ala Lys Val Phe Ala Gln Pro Asn Leu Ala Glu Met 
465                 470                 475                 480 


Ile Gln Lys Gly Glu Gln Leu Phe Leu Glu Pro Glu Leu Ile Ile Pro 
                485                 490                 495     


His Arg Gln His Arg Leu Phe Thr Val Thr Thr Ser Phe Leu Ser Pro 
            500                 505                 510         


Trp Pro Pro Val Val Thr Asp Ala Ser Phe Lys Val Lys Ser His Val 
        515                 520                 525             


Tyr Ser Leu Glu Gly Gln Asp Cys Lys Tyr Thr Pro Met Phe Gly Pro 
    530                 535                 540                 


Glu Ile Arg Thr Leu Val Leu Arg Leu Ala Gln Leu Ile Thr Gln Ala 
545                 550                 555                 560 


Lys Gln Thr Ala Lys Ser Ile Ser Asp Gln Tyr Val Glu Ser Pro Thr 
                565                 570                 575     


Gly Arg Ser Phe Leu Ser Trp Leu Thr Phe Gly Leu Thr Asp Thr Asn 
            580                 585                 590         


Ser Cys Tyr Pro Ala Asn Asp Leu Asp Glu Ile Gly Gln Asp Ser Ile 
        595                 600                 605             


Arg Lys Thr Asp Glu Tyr Leu Glu Lys Ala Leu Glu Tyr Leu Arg Gln 
    610                 615                 620                 


Ile Phe Arg Leu Ser Glu Ala Gln Leu Ala Gln Leu Thr Leu Ala Leu 
625                 630                 635                 640 


Gly Ser Ala Arg Asp Glu Asn Gly Lys Gln Gln Leu Pro Asp Cys Ile 
                645                 650                 655     


Val Gly Glu Glu Gly Leu Ile Leu Thr Pro Leu Gly Arg Tyr Gln Ile 
            660                 665                 670         


Ile Asn Gly Leu Arg Arg Phe Glu Ile Glu Tyr Gln Gly Asp Leu Glu 
        675                 680                 685             


Leu Gln Pro Ile Arg Ser Tyr Glu Ile Thr Ser Leu Val Arg Ala Leu 
    690                 695                 700                 


Phe Arg Leu Ser Ser Ala Ile Asn Arg Arg Phe Ala Gly Gln Met Ala 
705                 710                 715                 720 


Ala Leu Cys Ser Arg Asn Asp Phe Leu Gly Ser Phe Cys Arg Tyr His 
                725                 730                 735     


Leu Thr Glu Pro Ala Leu Ser Asn Arg His Leu Leu Ser Pro Val Gly 
            740                 745                 750         


Arg Arg Gln Val Thr Asn Pro Ala Arg Gly Pro Arg Leu Ser Leu Arg 
        755                 760                 765             


Phe Leu Gly Ser Tyr Arg Thr Leu Leu Leu Leu Leu Met Ala Phe Phe 
    770                 775                 780                 


Val Ala Ser Leu Phe Cys Ile Gly Pro Leu Ser Cys Ser Leu Leu Leu 
785                 790                 795                 800 


Val Leu Gly Tyr Val Leu Tyr Ala Ile Ala Met Thr Leu Leu Thr Glu 
                805                 810                 815     


Arg Gly Lys Leu His Gln Leu 
            820             


<210>  6
<211>  851
<212>  PRT
<213>  Gallus gallus

<400>  6

Met Asn Asp Asp Ala Asn Glu Ser Ala Thr Ala Glu Ala Arg Arg Glu 
1               5                   10                  15      


Ala Arg Leu Gly Asp Met Ala Gly Pro Tyr Leu Gln Gln Pro Ser Phe 
            20                  25                  30          


Leu Leu Ala Thr Leu Lys Ala Asp Cys Val Asn Lys Pro Phe Ala Gln 
        35                  40                  45              


Arg Cys His Asp Leu Glu Thr Val Ile Glu Glu Phe Pro Ala Lys Glu 
    50                  55                  60                  


Leu His Gly Ile Phe Pro Trp Leu Val Glu Ser Ile Phe Gly Ser Leu 
65                  70                  75                  80  


Asp Gly Thr Ile Val Gly Trp Asn Leu Arg Cys Leu Gln Gly Arg Thr 
                85                  90                  95      


Asn Pro Thr Glu Tyr Ser Val Ala Leu Asp Phe Leu Asp Pro Ser Gly 
            100                 105                 110         


Pro Met Met Lys Leu Val Tyr Lys Leu Gln Ala Glu Glu Tyr Arg Tyr 
        115                 120                 125             


Asp Phe Pro Val Ser Tyr Leu Pro Gly Pro Val Lys Ala Ser Ile Gln 
    130                 135                 140                 


Glu Gln Val Leu Pro Glu Cys Ser Leu Tyr His Asn Lys Val Gln Phe 
145                 150                 155                 160 


Pro Ser Ser Gly Gly Leu Gly Leu Asn Leu Ala Leu Asn Pro Phe Glu 
                165                 170                 175     


Tyr Tyr Met Phe Tyr Phe Ala Ile Ser Leu Ile Thr Gln Lys Asn Ser 
            180                 185                 190         


Pro Ile Thr His His Ile Ser Pro Ser Asn Ser Ala Tyr Phe Ile Leu 
        195                 200                 205             


Val Asp Thr Tyr Leu Lys Cys Phe Leu Pro Thr Glu Gly Ser Val Leu 
    210                 215                 220                 


Pro Pro Pro Ser Ser Asn Pro Gly Gly Ala Ile Pro Ser Pro Thr Pro 
225                 230                 235                 240 


Arg Ser Pro Ala Val Pro Phe Thr Ser Tyr Gly Met His His Thr Ser 
                245                 250                 255     


Leu Leu Lys Arg His Ile Ala His Gln Pro Ser Val Asn Ala Asp Pro 
            260                 265                 270         


Ala Ser Gln Glu Ile Trp Arg Ser Glu Thr Leu Leu Gln Ile Phe Val 
        275                 280                 285             


Glu Met Trp Leu His His Tyr Ser Leu Glu Met Tyr Gln Lys Met Gln 
    290                 295                 300                 


Ser Pro His Ile Lys Leu Glu Val Leu His Tyr Arg Leu Ser Ile Ser 
305                 310                 315                 320 


Ser Lys His His Gly Ser Pro Ala Gln Ser Ser Tyr Gln Ala Leu His 
                325                 330                 335     


Ala Tyr Gln Glu Ser Phe Lys Pro Thr Glu Glu His Val Leu Val Val 
            340                 345                 350         


Arg Leu Leu Val Lys His Leu His Ala Phe Ser Asn Ser Leu Lys Pro 
        355                 360                 365             


Glu Pro Leu Ser Pro Ser Ala His Ser His Thr Ala Ser Pro Leu Glu 
    370                 375                 380                 


Glu Phe Lys Arg Val Val Ile Pro Arg Phe Val Gln Gln Lys Leu Tyr 
385                 390                 395                 400 


Ile Phe Leu Gln His Cys Phe Gly His Trp Pro Leu Asp Ala Ser Phe 
                405                 410                 415     


Arg Ala Val Leu Glu Met Trp Leu Ser Tyr Leu Gln Pro Trp Arg Tyr 
            420                 425                 430         


Ala Pro Glu Lys Pro Pro Gln Thr Ala Glu Leu Leu Pro Arg Ser Val 
        435                 440                 445             


Ser Glu Lys Trp Ala Ala Phe Ile Gln Glu Asn Leu Leu Met Tyr Thr 
    450                 455                 460                 


Lys Leu Phe Val Gly Phe Leu Asn Arg Thr Leu Arg Thr Asp Leu Val 
465                 470                 475                 480 


Ser Pro Lys Asn Ala Leu Met Val Phe Arg Val Ala Lys Val Phe Ala 
                485                 490                 495     


Gln Pro Asn Leu Ala Glu Met Ile Leu Lys Gly Glu Gln Leu Phe Leu 
            500                 505                 510         


Glu Pro Glu Leu Val Ile Pro His Arg Gln His Arg Leu Phe Met Thr 
        515                 520                 525             


Pro Thr Leu Gly Gly Ser Phe Leu Ser Ser Trp Pro Pro Ala Ile Thr 
    530                 535                 540                 


Asp Ala Ser Phe Lys Val Lys Ser His Val Tyr Ser Leu Glu Gly Gln 
545                 550                 555                 560 


Asp Phe Gln Tyr Lys Gln Met Phe Gly Thr Glu Val Arg Asn Leu Val 
                565                 570                 575     


Leu Lys Leu Ala Gln Leu Ile Cys Gln Ala Gln Gln Thr Ala Lys Ser 
            580                 585                 590         


Ile Ser Asp His Ser Ala Glu Thr Thr Ala Ser His Ser Phe Phe Ser 
        595                 600                 605             


Trp Phe Lys Phe Thr Pro Ser Glu Met Asn Gly Ser Tyr Thr Gly Asn 
    610                 615                 620                 


Asp Leu Asp Glu Ile Gly Gln Asp Ser Ile Lys Lys Thr Asp Glu Tyr 
625                 630                 635                 640 


Leu Glu Lys Ala Leu Glu Tyr Leu Cys Gln Ile Phe Lys Leu Asn Glu 
                645                 650                 655     


Ala Gln Leu Thr Gln Met Met Met Lys Cys Gly Thr Ala Gln Asp Glu 
            660                 665                 670         


Asn Gly Lys Lys Gln Leu Pro Asp Cys Ile Glu Ser Glu Asn Gly Leu 
        675                 680                 685             


Ile Leu Thr Pro Leu Gly Arg Tyr Gln Met Ile Asn Gly Leu Arg Arg 
    690                 695                 700                 


Phe Asp Val Gln Tyr Gln Gly Asp Thr Glu Leu Gln Pro Ile Arg Ser 
705                 710                 715                 720 


Tyr Glu Asn Ala Thr Leu Val Arg Leu Leu Tyr Arg Leu Ser Ser Ala 
                725                 730                 735     


Leu Asn Glu Arg Leu Ala Asp Gln Met Asp Val Leu Cys Ser Arg Glu 
            740                 745                 750         


Asp Phe Val Gly Arg Phe Cys Arg Tyr His Leu Thr Asn Pro His Leu 
        755                 760                 765             


Val His Lys Ile Arg Tyr Ser Pro Val Leu Lys Asp Arg Thr Ser Gln 
    770                 775                 780                 


Asn Trp Gly Pro Arg Ile Ser Leu Arg Phe Leu Ala Ser Tyr Arg Thr 
785                 790                 795                 800 


Leu Ile Ser Leu Leu Met Leu Tyr Phe Ile Ala Ser Trp Phe His Ile 
                805                 810                 815     


Gly Pro Arg Leu His Ser Phe Gln Lys Leu Ser Leu Phe Met Pro Asn 
            820                 825                 830         


His Phe Ser Ala Asn Gln Lys Pro Val Pro Leu Ile Phe Asp Lys Val 
        835                 840                 845             


Pro Lys His 
    850     


<210>  7
<211>  791
<212>  PRT
<213>  Danio rerio

<400>  7

Met Ala Ala Ser Ala Leu Gln Gln Pro Ser Tyr Leu Leu Ala Asn Leu 
1               5                   10                  15      


Lys Ala Asp Trp Thr Asn Lys Pro Leu His Gln Arg Cys His Glu Leu 
            20                  25                  30          


Cys Lys Ile Ile Asp Asp Tyr Pro Ala Lys Glu Leu His Ala Ile Phe 
        35                  40                  45              


Pro Trp Leu Val Glu Cys Val Phe Gly Ser Leu Asp Gly Ile Leu Thr 
    50                  55                  60                  


Gly Trp Asn Leu Arg Phe Leu Gln Ala Arg Ser Ala Glu Tyr Ser Ile 
65                  70                  75                  80  


Ala Met Glu Phe Leu Asp Pro Ser Gly Pro Met Met Lys Leu Val Tyr 
                85                  90                  95      


Lys Leu Gln Ala Glu Glu Tyr Lys Tyr Glu Phe Pro Ile Ser Tyr Leu 
            100                 105                 110         


Pro Gly Pro Ile Lys Ser Ser Ile His Ala Gly Val Leu Pro Asp Cys 
        115                 120                 125             


Pro Leu Phe His Asn Lys Ile Gln Phe Pro Met Ser Gly Leu Leu Phe 
    130                 135                 140                 


Leu Asn Pro Phe Glu Tyr Tyr Met Phe Asn Phe Ala Ser Ser Leu Ile 
145                 150                 155                 160 


Ala Pro Lys Asn Tyr Pro Gln Gly Gln His Gly Ser Ser Ser Asp Ser 
                165                 170                 175     


Ala Tyr Phe Val Leu Val Asp Thr Tyr Leu Lys Tyr Phe Leu Pro Thr 
            180                 185                 190         


Glu Gly Asn Val Pro Pro Ser Pro Phe Ser Asp Thr Arg Gly Thr Val 
        195                 200                 205             


Ala Ser Pro Ala Pro Arg Ser Thr Asn Val Pro Tyr Val Gly Tyr Gly 
    210                 215                 220                 


Gly His Ser Thr Ser Leu Leu Lys Arg His Ile Thr His Gln Ser Ser 
225                 230                 235                 240 


Val Asn Ala Asp Pro Ala Ala Gln Glu Ile Trp Arg Ser Glu Thr Leu 
                245                 250                 255     


Leu Gln Val Phe Val Glu Met Trp Leu His His Tyr Ser Leu Glu Met 
            260                 265                 270         


Tyr Gln Lys Leu Gln Ser Pro Gln Val Lys Glu Pro Phe Met Pro Ser 
        275                 280                 285             


Glu Glu His Val Leu Val Val Arg Leu Leu Val Lys His Leu His Thr 
    290                 295                 300                 


Phe Ser Ser Ser Leu Lys Pro Glu Ser Ile Ser Ser Ser Pro Ser Ala 
305                 310                 315                 320 


His Ser His Ser Ser Pro Leu Glu Glu Leu Lys Arg Val Val Val Gln 
                325                 330                 335     


Arg Phe Val Gln Gln Lys Leu Tyr Val Phe Leu Gln His Cys Phe Gly 
            340                 345                 350         


His Trp Pro Leu Asp Ala Ser Phe Arg Ala Val Leu Glu Thr Trp Leu 
        355                 360                 365             


Ser Tyr Ile Gln Pro Trp Arg Tyr Thr Gly Asp Lys Asn Asn Thr Gln 
    370                 375                 380                 


Thr Asp Gly Pro Asn Arg Thr Val Pro Asp Lys Trp Ala Ser Phe Val 
385                 390                 395                 400 


Gln Glu Asn Leu Leu Leu Tyr Thr Lys Leu Phe Gln Gly Phe Leu Asn 
                405                 410                 415     


Arg Ala Met Arg Thr Asp Leu Val Asn Ala Lys Asn Ala Leu Met Val 
            420                 425                 430         


Phe Arg Val Ala Lys Val Phe Ala Gln Pro Ser Leu Ser Glu Met Ile 
        435                 440                 445             


Gln Lys Gly Glu Gln Leu Phe Leu Glu Pro Glu His Ala Ile Leu Gln 
    450                 455                 460                 


Arg His Asn Arg Val Phe Leu Thr Pro Ser His Gly Gly Ser Phe Leu 
465                 470                 475                 480 


Ser Ala Arg Gln Pro Met Gly Thr Asp Asn Val Phe Lys Val Lys Ser 
                485                 490                 495     


His Val Tyr Ser Leu Glu Gly Gln Asp Cys Gln Tyr Asn Leu Met Phe 
            500                 505                 510         


Gly Pro Asp Gln Arg Lys Asn Val Leu Lys Leu Ile Gln Ile Ile Ala 
        515                 520                 525             


Gln Ala Arg Gln Thr Ala Lys Arg Ile Ser Asp His Ser Thr Glu Met 
    530                 535                 540                 


Ala Ala Asn Asn Ser Phe Leu Ser Trp Phe Gly Val Gly Ser Pro Asp 
545                 550                 555                 560 


His Asn Ser Thr Phe Thr Gly Gly Glu Met Asp Glu Met Gly Gly Glu 
                565                 570                 575     


Gly Val Lys Lys Thr His Glu Phe Leu Asp Lys Ala Leu Asp Tyr Leu 
            580                 585                 590         


Cys Gln Ile Phe Arg Leu Asn Ala Gly Gln Leu Ser Gln Leu Ile Ser 
        595                 600                 605             


Asn Val Ala Ser Val Asp Asn Asn Gly Ala Ser Lys Gln Leu Pro Asp 
    610                 615                 620                 


Cys Ile Pro Ser Glu Asn Gly Leu Val Leu Thr Asp Leu Gly Arg Leu 
625                 630                 635                 640 


Gln Ile Ile Asn Gly Leu Arg Arg Phe Glu Ile Glu Tyr Gln Gly Asp 
                645                 650                 655     


Pro Glu Leu Gln Pro Ile Arg Ser Tyr Glu Asn Ala Phe Leu Val Arg 
            660                 665                 670         


Leu Leu Phe Gln Ile Ser Ser Phe Ile Asn Glu Arg Leu Gly Glu His 
        675                 680                 685             


Met Glu Val Leu Cys Ser Arg Gln Asp Phe Leu Gly Ser Val Gly Arg 
    690                 695                 700                 


His Tyr Leu Ser Ser Ser Ser Ala Val Val Glu Gln Arg Arg Lys Ser 
705                 710                 715                 720 


Pro Val Thr Arg Gln Met Arg Asp Arg Pro Gln Arg Ala Arg Leu Ser 
                725                 730                 735     


Leu Arg Ala Leu Ala Ser Tyr Arg Thr Leu Leu Thr Leu Leu Leu Leu 
            740                 745                 750         


Tyr Met Leu Phe Ala Leu Leu Ser Phe Gly Leu Phe Ser Ser Thr Gly 
        755                 760                 765             


Leu Ile Leu Ile Ile Ser Phe Leu Tyr Glu Leu Leu Ser Asn Phe Phe 
    770                 775                 780                 


His Glu Lys Leu Lys Thr His 
785                 790     


<210>  8
<211>  767
<212>  PRT
<213>  Drosophila melanogaster

<400>  8

Met Ser Gln Thr Met Pro Pro Glu Asn Leu Ser Ser Arg Leu Leu Thr 
1               5                   10                  15      


Val Leu Ser Leu Pro Leu Phe Glu Arg Val His Glu Leu Ser Ile Leu 
            20                  25                  30          


Phe Asp Arg Cys Ser Leu Arg Gln Val Gln Glu Ile Phe Pro His Val 
        35                  40                  45              


Val His Ser Ile Phe Gly Ile Asp Gly Asn Pro Leu Gly Trp Gly Leu 
    50                  55                  60                  


Arg Thr Thr Thr Leu Glu Asn Asn Pro Val Gln Phe Gln Thr Leu His 
65                  70                  75                  80  


Gln Phe Phe Gly Val Cys Gly Pro Leu Met His Val Cys His Arg Leu 
                85                  90                  95      


Leu Val Asp Gln Tyr Lys Phe Glu Leu Asp Ile Asn Leu Leu Pro Ala 
            100                 105                 110         


Lys Phe Val Ser Leu Leu Gln Asn Gly Gln Asn Pro Ser Phe Tyr Ala 
        115                 120                 125             


Glu Leu Ile Asn Val Glu Thr Met Met His Gln Val Ser Thr Leu Ser 
    130                 135                 140                 


Leu Asn Ala Phe Asp Phe Tyr Val Ile His Phe Val Leu Tyr Ala Leu 
145                 150                 155                 160 


Gln Pro Leu His Ser Ile Asn Pro Ile Ala Met Gln Ile His Asn Val 
                165                 170                 175     


Arg Ser Lys Thr Val Tyr Leu Lys Leu Val Ala Glu Tyr Leu Asn Asn 
            180                 185                 190         


Phe Leu Pro Leu Leu Pro Asp Ala Arg Ile Glu Pro Val His Phe Ser 
        195                 200                 205             


Ser Gly Val Lys Ala Pro Gln Pro Leu Pro Ala Gln Ala Leu Gln Pro 
    210                 215                 220                 


Gln Arg Gln Pro Arg Tyr Ile Lys Ile Pro Ser Ser Tyr Arg Asn Gly 
225                 230                 235                 240 


Gly Asn Val Ser Gly Gly Gly Gly Ile Pro Ser Ala Ser Val Gly Val 
                245                 250                 255     


Gly Asn Ile Ser Pro Gln Ser Asn Ser Pro Ser Ala Ser Ser Asn Arg 
            260                 265                 270         


Ala Tyr Ala Trp Arg Ser Glu Ser Val Leu His Phe Phe Val Asp Ile 
        275                 280                 285             


Trp Leu Arg Tyr Asp Ile Glu Ser Glu His His Leu Pro Ser Ser Asp 
    290                 295                 300                 


Phe Val Arg Gly Val Arg Thr Leu Val Lys Gln Val His Phe Phe Ala 
305                 310                 315                 320 


Asn Gly Ala Gln His Asp His Ser Ser Leu Cys Ala Leu Arg Lys Val 
                325                 330                 335     


Ser Leu Ser Met Val Lys Ala Arg Ile Tyr Ala Phe Ile Val Gly Leu 
            340                 345                 350         


Ile Asp Arg Trp Pro Leu Asp Ser Ser Leu Met Val Val Leu Glu Leu 
        355                 360                 365             


Trp Leu Ser Tyr Ile Gln Pro Trp Arg Tyr Thr Ile Ala Ser Leu Asn 
    370                 375                 380                 


Asn Lys Thr Pro Ser Leu Ser Tyr Arg Pro Pro Ile Ser Ser Cys Phe 
385                 390                 395                 400 


Asp Gly Phe Ile Ile Asp Asn Leu Ile Met Tyr Thr His Ile Phe Met 
                405                 410                 415     


Gln Leu Leu Pro His Phe Gly Arg Leu Asp Tyr Thr Val Tyr Arg Asn 
            420                 425                 430         


Ala Phe Met Leu Tyr Arg Leu Ala Thr Ile Phe Ser Gln His Asp Leu 
        435                 440                 445             


Val Asp Lys Leu Gln Arg Phe Glu Ala Ile His Ala Gly Asn Ser Phe 
    450                 455                 460                 


Gly Phe Asp Ser Pro Gln Arg Gln Val Asn Ile Met Asn Lys Ser Val 
465                 470                 475                 480 


Ser Pro Gly Thr Pro Trp Asn Gln Ala Val Asn Ile Ser Ser Ala Lys 
                485                 490                 495     


Leu Phe Ser Tyr Thr Met Gln Thr Gln Met Glu Thr Phe Leu Leu Leu 
            500                 505                 510         


Ile Ser Met Ala Arg Asn Ser Val Leu Arg Asp Ile Ala Lys Leu Arg 
        515                 520                 525             


Asn Glu Ile Ala Glu Arg Gln Arg Ser Glu Gly Phe Leu Lys Asn Phe 
    530                 535                 540                 


Tyr Lys Lys Ile Phe Gly Glu Cys Thr Gln Glu Glu Val Thr Leu Arg 
545                 550                 555                 560 


Glu Phe Ser Arg Ile Pro Glu Val Leu Arg Gln Cys Ile Asp Ala Phe 
                565                 570                 575     


Cys Arg Thr Phe Asn Val Asp Gln Ala Asn Leu Ser Met His Glu Thr 
            580                 585                 590         


Leu Pro Glu Glu Pro Ser Val Pro Ser Ala Pro Ala Val Gln Asn Phe 
        595                 600                 605             


Ser Phe Phe Asp Ala Ser Asp Thr Leu Asp Thr Ser Lys Leu Asn Pro 
    610                 615                 620                 


His Gln Met Ser Leu Asn Ala Ser Ser Leu His Ala Ala Val Asp Pro 
625                 630                 635                 640 


Ala Thr Leu Pro Ile Gln Thr Asn Glu Val Arg Ala Leu Val Arg Met 
                645                 650                 655     


Leu His Phe Val Ser Glu Lys Ile Asn Asn Lys Tyr Gly Ser Gln Leu 
            660                 665                 670         


Gln Gly Phe Tyr Val Arg Asp Asp Tyr Phe Gly Lys Val Ala Arg Gln 
        675                 680                 685             


Leu Leu Tyr Ala Pro Met Thr Glu Gln Trp Phe Asp Lys Ser Ser Gly 
    690                 695                 700                 


His Val Glu Ile Cys Glu Asn Leu Val Pro Pro Arg Val Cys Leu Arg 
705                 710                 715                 720 


Pro Leu Gly Ser Ile Pro Ala Leu Thr Thr Ile Gly Cys Ser Met Ile 
                725                 730                 735     


Phe Gly Gln Leu Val Trp Gly Ala Pro Leu Leu Gly Ile Phe Ile Leu 
            740                 745                 750         


Ala Thr Val Leu Leu Val Tyr Ile Met Leu Gln Ala Leu Phe Ser 
        755                 760                 765         


<210>  9
<211>  640
<212>  PRT
<213>  Caenorhabditis elegans

<400>  9

Met Phe Gln Gln Arg Gln Thr Pro Thr Glu Phe Ser Gln Met Asp Asp 
1               5                   10                  15      


Val Val Ser Ile Cys Arg Glu Ile Ser Ser Asn Ile Ile Ser Thr Asp 
            20                  25                  30          


Lys Asn Val Pro Ile Ser Lys Met Ile Ile His Lys Ile Phe Lys Asn 
        35                  40                  45              


Pro His Ile Asp Leu Cys Ser Ile Leu Pro Pro Leu Ile Gln Gln His 
    50                  55                  60                  


Tyr Pro Asp Ser Pro Tyr Cys His Ile Gln Ser Leu Ile Asn Ser Asn 
65                  70                  75                  80  


Ser Val Phe Phe Glu Thr Val Leu Glu Asp Asp Gln Leu Cys Thr Glu 
                85                  90                  95      


Leu Trp Asp Ser Ile Leu His Gln Cys Glu Val Ser Thr Ala Pro Thr 
            100                 105                 110         


Glu Pro Ala Lys Asp Ser Ile Leu Phe Ser Ala Val Ser Gln Tyr Val 
        115                 120                 125             


Thr Arg Ile Leu Pro Cys Asp Glu Thr Ala Pro Ser Ser Met Ser Val 
    130                 135                 140                 


Pro Arg Ser Pro Lys Ile Thr His Gln Thr Ile Arg Thr Pro Leu Gln 
145                 150                 155                 160 


Leu Phe Arg Ala Asp Ser Pro Leu Val Asn Arg Val Ser Ile Glu Glu 
                165                 170                 175     


Arg Ser Gln Met Met Ser Val Ser Thr Val Ser Phe Gln Pro Arg Leu 
            180                 185                 190         


Val Gln Asn Phe Cys Asn Phe Val Thr Lys Ser Cys Thr Thr Ala Gln 
        195                 200                 205             


Phe Thr Asn Ala Asn Lys Leu Leu Leu Ile Arg Tyr Leu Leu Lys Gln 
    210                 215                 220                 


Phe His Val Phe Cys Gln Phe Ser Thr Gly Asp Pro Glu Val Asp Asn 
225                 230                 235                 240 


Trp Lys Leu Asp Leu Met Ala Ser Ala Pro Phe Arg Phe Ser Leu Tyr 
                245                 250                 255     


Asp Phe Phe Lys Ser Ser Val Thr Gln Val Pro Thr Thr Ile Val Phe 
            260                 265                 270         


Arg Asp Ile Thr Met Cys Trp Leu Thr Tyr Cys Arg Pro Trp Arg Tyr 
        275                 280                 285             


His Asn Met Ser Asn Pro Ser Asp Phe Ala Pro Ala Ala Lys Tyr Arg 
    290                 295                 300                 


Gln Phe Phe Glu Lys Asn Val Glu Phe Tyr Glu Val Ile Leu Gly Lys 
305                 310                 315                 320 


Ile Leu Lys Arg Phe Ser Ala Phe Glu Met Cys Glu Glu Leu Leu Gly 
                325                 330                 335     


Ser Leu Arg Ala Ile Ile Glu Phe Ala Trp Lys Glu Pro Gln Thr Leu 
            340                 345                 350         


Leu Leu Arg His Ile Gln Leu Asp Ile Gln Pro His Ser Leu Glu Leu 
        355                 360                 365             


Leu Lys Gln Met Gln Val Val Val Arg Met His Arg Ser Ala Ile Gln 
    370                 375                 380                 


Lys Glu Gln Asp Glu His Ser Gly Phe Trp Asn Ser Leu Phe Tyr Ser 
385                 390                 395                 400 



Gly Asp Ser Ala Arg Thr Gln Ser Ser Arg Arg Leu Val Ser Glu Leu 
                405                 410                 415     


Leu Thr Leu Met Lys Asp Ser Asp Ser Tyr Val Gly Thr His Phe Met 
            420                 425                 430         


Pro Glu Met Glu Asp Ser Val Leu Ala Asn Arg Thr Gly Asn Glu Thr 
        435                 440                 445             


Phe His Lys Glu Lys Leu Tyr Thr Ser Leu Leu Asn Glu Thr Pro Lys 
    450                 455                 460                 


Ser Gly Leu Gly Ile Pro Asp His Phe Val Asp Gly Pro Ser Asn His 
465                 470                 475                 480 


Met Leu Leu Thr Pro Ile Gly Gln Arg Gln Val Leu Asn Arg Glu Lys 
                485                 490                 495     


Arg Phe Asp Tyr Ser Asn Cys Ile Lys Asp Asp Pro Lys Ala Pro Thr 
            500                 505                 510         


Arg Ser Tyr Glu Leu Gly Ile Ala Val Lys Leu Thr Thr Ser Leu Ala 
        515                 520                 525             


Gln Lys Leu Asn Glu Leu Ser Phe Val Gln Lys Ile Gly Asp His Tyr 
    530                 535                 540                 


Ser Gln Gln Ser Val Ile Gly Ala Ile Ala Arg Lys Val Met Tyr Pro 
545                 550                 555                 560 


Pro Val Pro Asn Leu Asp Pro Asn Ala Thr Val Pro Ala Tyr Ser Ala 
                565                 570                 575     


Arg Ile Ile Arg Ser Pro Pro Leu Leu Arg Leu Arg Tyr Phe Ala Ser 
            580                 585                 590         


Tyr Gln Ser Ile Phe Phe Met Ile Trp Leu Leu Phe Ala Leu Lys Tyr 
        595                 600                 605             


Gly Leu Thr Phe Thr Ile Val Ser Leu Ile Leu Ile Ala Leu Ser Val 
    610                 615                 620                 


Thr Val Leu Leu Phe Ile Glu Leu Asp Ser Gly Ser Ser Ser Ser Tyr 
625                 630                 635                 640 


<210>  10
<211>  7303
<212>  DNA
<213>  Artificial

<220>
<223>  pRK-nSMase3

<400>  10
tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct ggcattatgc     60

ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat tagtcatcgc    120

tattaccatg gtgatgcggt tttggcagta catcaatggg cgtggatagc ggtttgactc    180

acggggattt ccaagtctcc accccattga cgtcaatggg agtttgtttt ggcaccaaaa    240

tcaacgggac tttccaaaat gtcgtaacaa ctccgcccca ttgacgcaaa tgggcggtag    300

gcgtgtacgg tgggaggtct atataagcag agctcgttta gtgaaccgtc agatcgcctg    360

gagacgccat ccacgctgtt ttgacctcca tagaagacac cgggaccgat ccagcctccg    420

cggccgggaa cggtgcattg gaacgcggat tccccgtgcc aagagtgacg taagtaccgc    480

ctatagagtc tataggccca cccccttggc ttcgttagaa cgcggctaca attaatacat    540

aaccttatgt atcatacaca tacgatttag gtgacactat agaataacat ccactttgcc    600

tttctctcca caggtgtcca ctcccaggtc caactgcacc tcggttctat cgattgaatt    660

ctgatgacga ctttcggcgc cgtggcggaa tggcggcttc catctctgag gcgagcgacg    720

ctatggatcc cacagtggtt tgctaagaag gccattttca actctccact ggaggctgct    780

atggcgttcc ctcacctgca gcagcccagc tttctactgg ctagcctgaa agctgactct    840

ataaataagc cctttgcaca gcagtgccaa gacttggtta aagtcattga ggactttcca    900

gcaaaggagc tgcacaccat cttcccatgg ctggtagaaa gcatttttgg cagcctagat    960

ggtgtcctcg ttggctggaa cctccgctgc ttacaggggc gcgtgaatcc tgtggagtac   1020

agcatcgtga tggaatttct cgaccctggt ggcccaatga tgaagttggt ttataagctt   1080

caagctgaag actataagtt cgactttcct gtctcctact tgcctggtcc tgtgaaggcg   1140

tccatccagg agtgcatcct ccctgacagt cctctgtacc acaacaaggt ccagttcacc   1200

cctactgggg gccttggtct gaacttggcc ctgaatccgt tcgagtatta catattcttc   1260

tttgccttga gcctcatcac tcagaagcca cttcctgtgt ccctccacgt ccgtacttca   1320

gactgtgcct atttcatcct ggtggacagg tacctgtcat ggttcctgcc caccgaaggc   1380

agtgtgcccc caccactctc ctccagccca ggggggacca gcccctcacc acctcccagg   1440

acaccagcca taccctttgc ttcctatggc ctccaccaca ctagcctcct aaagcgacac   1500

atctctcatc agacgtctgt gaatgcagac cccgcctccc acgagatctg gaggtcagaa   1560

actctgctcc aggtttttgt tgaaatgtgg cttcatcact attccttgga gatgtatcaa   1620

aaaatgcagt cccctcatgc caagctggag gttctgcact accgactcag tgtctccagc   1680

gccctctaca gccccgccca acccagcctc caggccctcc acgcctacca agagtcgttc   1740

acgcctactg aggagcatgt gttggtggtg cgcctgctgc tgaagcacct gcacgccttt   1800

gccaacagcc tgaagccaga gcaggcctca ccctccgccc actcccacgc caccagcccc   1860

ctggaggagt tcaaacgggc tgctgtcccg aggttcgtcc agcagaaact ctacctcttc   1920

ttgcagcatt gctttggcca ctggcccctg gacgcatcgt tcagagctgt cctggagatg   1980

tggctgagct acctgcagcc gtggcggtac gcgcctgaca agcaggctcc gggcagcgac   2040

tcccagcccc ggtgtgtgtc ggagaaatgg gcaccctttg tccaggagaa cctgctgatg   2100

tacaccaagt tgtttgtggg ctttctgaac cgcgcgctcc gcacagacct ggtcagcccc   2160

aagcacgcgc tcatggtgtt ccgagtggcc aaagtctttg cccagcccaa cctggctgag   2220

atgattcaga aaggtgagca gctattcctg gagccagagc tggtcatccc ccaccgccag   2280

caccgactct tcacggcccc cacattcact gggagcttcc tgtcaccctg gccaccagcg   2340

gtcactgatg cctccttcaa ggtgaagagc cacgtctaca gcctggaggg ccaggactgc   2400

aagtacaccc cgatgtttgg gcccgaggcc cgcaccctgg tcctgcgcct cgctcagctc   2460

atcacacagg ccaaacacac agccaagtcc atctccgacc agtgtgcgga gagcccggct   2520

ggccactcct tcctctcatg gctgggcttt agctccatgg acaccaatgg ctcctacaca   2580

gccaacgacc tggacgagat ggggcaagac agtgtccgga agacagatga atacctggag   2640

aaggccctgg agtacctgcg ccagatattc cggctcagcg aagcgcagct caggcagttc   2700

acactcgcct tgggcaccac ccaggatgag aatggaaaaa agcaactccc cgactgcatc   2760

gtgggtgagg acggactcat ccttacgccc ctggggcggt accagatcat caatgggctg   2820

cgaaggtttg aaattgagta ccagggggac ccggagctgc agcccatccg gagctatgag   2880

atcgccagct tggtccgcac actctttagg ctgtcgtctg ccatcaacca cagatttgca   2940

ggacagatgg cggctctgtg ttcccgggat gacttcctcg gcagcttctg tcgctaccac   3000

ctcacagaac ctgggctggc cagcaggcac ctgctgagcc ctgtggggcg gaggcaggtg   3060

gccggccaca cccgcggccc caggctcagc ctgcgcttcc tgggcagtta ccggacgctg   3120

gtctcgctgc tgctggcctt cttcgtggcc tctctgttct gcgtcgggcc cctcccatgc   3180

acgctgctgc tcaccctggg ctatgtcctc tacgcctctg ccatgacact gctgaccgag   3240

cgggggaagc tgcaccagcc ctgacgtcga cctgcagaag cttggccgcc atggcccaac   3300

ttgtttattg cagcttataa tggttacaaa taaagcaata gcatcacaaa tttcacaaat   3360

aaagcatttt tttcactgca ttctagttgt ggtttgtcca aactcatcaa tgtatcttat   3420

catgtctgga tcgatcggga attaattcgg cgcagcacca tggcctgaaa taacctctga   3480

aagaggaact tggttaggta ccttctgagg cggaaagaac cagctgtgga atgtgtgtca   3540

gttagggtgt ggaaagtccc caggctcccc agcaggcaga agtatgcaaa gcatgcatct   3600

caattagtca gcaaccaggt gtggaaagtc cccaggctcc ccagcaggca gaactatgca   3660

aagcatgcat ctcaattagt cagcaaccat agtcccgccc ctaactccgc ccatcccgcc   3720

cctaactccg cccagttccg cccattctcc gccccatggc tgactaattt tttttattta   3780

tgcagaggcc gaggccgcct cggcctctga gctattccag aagtagtgag gaggcttttt   3840

tggaggccta ggcttttgca aaaagctgtt aacagcttgg cactggccgt cgttttacaa   3900

cgtcgtgact gggaaaaccc tggcgttacc caacttaatc gccttgcagc acatcccccc   3960

ttcgccagct ggcgtaatag cgaagaggcc cgcaccgatc gcccttccca acagttgcgt   4020

agcctgaatg gcgaatggcg cctgatgcgg tattttctcc ttacgcatct gtgcggtatt   4080

tcacaccgca tacgtcaaag caaccatagt acgcgccctg tagcggcgca ttaagcgcgg   4140

cgggtgtggt ggttacgcgc agcgtgaccg ctacacttgc cagcgcccta gcgcccgctc   4200

ctttcgcttt cttcccttcc tttctcgcca cgttcgccgg ctttccccgt caagctctaa   4260

atcgggggct ccctttaggg ttccgattta gtgctttacg gcacctcgac cccaaaaaac   4320

ttgatttggg tgatggttca cgtagtgggc catcgccctg atagacggtt tttcgccctt   4380

tgacgttgga gtccacgttc tttaatagtg gactcttgtt ccaaactgga acaacactca   4440

accctatctc gggctattct tttgatttat aagggatttt gccgatttcg gcctattggt   4500

taaaaaatga gctgatttaa caaaaattta acgcgaattt taacaaaata ttaacgttta   4560

caattttatg gtgcactctc agtacaatct gctctgatgc cgcatagtta agccaactcc   4620

gctatcgcta cgtgactggg tcatggctgc gccccgacac ccgccaacac ccgctgacgc   4680

gccctgccgg gcttgtctgc tcccggcatc cgcttacaga caagctgtga ccgtctccgg   4740

gagctgcatg tgtcagaggt tttcaccgtc atcaccgaaa cgcgcgaggc agtattcttg   4800

aagacgaaag ggcctcgtga tacgcctatt tttataggtt aatgtcatga taataatggt   4860

ttcttagacg tcaggtggca cttttcgggg aaatgtgcgc ggaaccccta tttgtttatt   4920

tttctaaata cattcaaata tgtatccgct catgagacaa taaccctgat aaatgcttca   4980

ataatattga aaaaggaaga gtatgagtat tcaacatttc cgtgtcgccc ttattccctt   5040

ttttgcggca ttttgccttc ctgtttttgc tcacccagaa acgctggtga aagtaaaaga   5100

tgctgaagat cagttgggtg cacgagtggg ttacatcgaa ctggatctca acagcggtaa   5160

gatccttgag agttttcgcc ccgaagaacg ttttccaatg atgagcactt ttaaagttct   5220

gctatgtggc gcggtattat cccgtgatga cgccgggcaa gagcaactcg gtcgccgcat   5280

acactattct cagaatgact tggttgagta ctcaccagtc acagaaaagc atcttacgga   5340

tggcatgaca gtaagagaat tatgcagtgc tgccataacc atgagtgata acactgcggc   5400

caacttactt ctgacaacga tcggaggacc gaaggagcta accgcttttt tgcacaacat   5460

gggggatcat gtaactcgcc ttgatcgttg ggaaccggag ctgaatgaag ccataccaaa   5520

cgacgagcgt gacaccacga tgccagcagc aatggcaaca acgttgcgca aactattaac   5580

tggcgaacta cttactctag cttcccggca acaattaata gactggatgg aggcggataa   5640

agttgcagga ccacttctgc gctcggccct tccggctggc tggtttattg ctgataaatc   5700

tggagccggt gagcgtgggt ctcgcggtat cattgcagca ctggggccag atggtaagcc   5760

ctcccgtatc gtagttatct acacgacggg gagtcaggca actatggatg aacgaaatag   5820

acagatcgct gagataggtg cctcactgat taagcattgg taactgtcag accaagttta   5880

ctcatatata ctttagattg atttaaaact tcatttttaa tttaaaagga tctaggtgaa   5940

gatccttttt gataatctca tgaccaaaat cccttaacgt gagttttcgt tccactgagc   6000

gtcagacccc gtagaaaaga tcaaaggatc ttcttgagat cctttttttc tgcgcgtaat   6060

ctgctgcttg caaacaaaaa aaccaccgct accagcggtg gtttgtttgc cggatcaaga   6120

gctaccaact ctttttccga aggtaactgg cttcagcaga gcgcagatac caaatactgt   6180

ccttctagtg tagccgtagt taggccacca cttcaagaac tctgtagcac cgcctacata   6240

cctcgctctg ctaatcctgt taccagtggc tgctgccagt ggcgataagt cgtgtcttac   6300

cgggttggac tcaagacgat agttaccgga taacgcgcag cggtcgggct gaacgggggg   6360

ttcgtgcaca cagcccagct tggagcgaac gacctacacc gaactgagat acctacagcc   6420

tgagcattga gaaagcgcca cgcttcccga agggagaaag gcggacaggt atccggtaag   6480

cggcagggtc ggaacaggag agcgcacgag ggagcttcca gggggaaacg cctggtatct   6540

ttatagtcct gtcgggtttc gccacctctg acttgagcgt cgatttttgt gatgctcgtc   6600

aggggggcgg agcctatgga aaaacgccag caacgcggcc tttttacggt tcctggcctt   6660

ttgctggcct tttgctcaca tgttctttcc tgcgttatcc cctgattctg tggataaccg   6720

tattaccgcc tttgagtgag ctgataccgc tcgccgcagc cgaacgaccg agcgcagcga   6780

gtcagtgagc gaggaagcgg aagagcgccc aatacgcaaa ccgcctctcc ccgcgcgttg   6840

gccgaatcat taatccagct ggcacgacag gtttcccgac tggaaagcgg gcagtgagcg   6900

caacgcaatt aatgtgagtt acctcactca ttaggcaccc caggctttac actttatgct   6960

tccggctcgt atgttgtgtg gaattgtgag cggataacaa tttcacacag gaaacagcta   7020

tgaccatgat tacgaattaa ttcgagctcg cccgacattg attattgact agttattaat   7080

agtaatcaat tacggggtca ttagttcata gcccatatat ggagttccgc gttacataac   7140

ttacggtaaa tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg acgtcaataa   7200

tgacgtatgt tcccatagta acgccaatag ggactttcca ttgacgtcaa tgggtggagt   7260

atttacggta aactgcccac ttggcagtac atcaagtgta tca                     7303


<210>  11
<211>  6678
<212>  DNA
<213>  Artificial

<220>
<223>  pRK-nSMase2

<400>  11
tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct ggcattatgc     60

ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat tagtcatcgc    120

tattaccatg gtgatgcggt tttggcagta catcaatggg cgtggatagc ggtttgactc    180

acggggattt ccaagtctcc accccattga cgtcaatggg agtttgtttt ggcaccaaaa    240

tcaacgggac tttccaaaat gtcgtaacaa ctccgcccca ttgacgcaaa tgggcggtag    300

gcgtgtacgg tgggaggtct atataagcag agctcgttta gtgaaccgtc agatcgcctg    360

gagacgccat ccacgctgtt ttgacctcca tagaagacac cgggaccgat ccagcctccg    420

cggccgggaa cggtgcattg gaacgcggat tccccgtgcc aagagtgacg taagtaccgc    480

ctatagagtc tataggccca cccccttggc ttcgttagaa cgcggctaca attaatacat    540

aaccttatgt atcatacaca tacgatttag gtgacactat agaataacat ccactttgcc    600

tttctctcca caggtgtcca ctcccaggtc caactgcacc tcggttctat cgattgaatt    660

ccccggggat ccatggtttt gtacacgacc ccctttccta acagctgtct gtccgccctg    720

cactgtgtgt cctgggccct tatctttcca tgctactggc tggtggaccg gctcgctgcc    780

tccttcatac ccaccaccta cgagaagcgc cagcgggcag acgacccgtg ctgcctgcag    840

ctgctctgca ctgccctctt cacgcccatc tacctggccc tcctggtggc ctcgctgccc    900

tttgcgtttc tcggctttct cttctggtcc ccactgcagt cggcccgccg gccctacatc    960

tattcacggc tggaagacaa gggcctggcc ggtggggcag ccctgctcag tgaatggaag   1020

ggcacggggc ctggcaaaag cttctgcttt gccactgcca acgtctgcct cctgcccgac   1080

tcactcgcca gggtcaacaa cctttttaac acccaagcgc gggccaagga gatcgggcag   1140

agaatccgca atggggccgc ccggccccag atcaaaattt acatcgactc ccccaccaat   1200

acctccatca gcgccgctag cttcagcagc ctggtgtcac cacagggcgg cgatggggtg   1260

gcccgggccg tccccgggag cattaagagg acagcctctg tggagtacaa gggtgacggt   1320

gggcggcacc ccggtgacga ggctgccaac ggcccagcct ctggggaccc tgtcgacagc   1380

agcagcccgg aggatgcctg catcgtgcgc atcggtggcg aggagggcgg ccggccacct   1440

gaagctgacg accctgtgcc tgggggccag gccaggaacg gagctggcgg gggcccaagg   1500

ggccagacgc ccaaccataa tcagcaggac ggggattcag ggagcctggg cagcccctcg   1560

gcctcccggg agtccctggt gaaggggcga gctgggccag acaccagtgc cagcggggag   1620

ccaggtgcca acagcaagct cctgtacaag gcctcggtgg tgaagaaggc ggctgcacgc   1680

aggaggcggc accccgacga ggccttcgac catgaggtct ccgccttctt ccccgccaac   1740

ctggacttcc tgtgcctgca ggaggtgttt gacaagcgag cagccaccaa attgaaagag   1800

cagctgcacg gctacttcga gtacatcctg tacgacgtcg gggtctacgg ctgccagggc   1860

tgctgcagct tcaagtgtct caacagcggc ctcctctttg ccagccgcta ccccatcatg   1920

gacgtggcct atcactgtta ccccaacaag tgtaacgacg atgccctggc ctctaaggga   1980

gctctgtttc tcaaggtgca ggtgggaagc acacctcagg accaaagaat cgtcgggtac   2040

atcgcctgca cacacctgca tgccccacaa gaggacagcg ccatccggtg tgggcagctg   2100

gacctgcttc aggactggct ggctgatttc cgaaaatcta cctcctcgtc cagcgcagcc   2160

aaccccgagg agctggtggc atttgacgtc gtctgtggag atttcaactt tgataactgc   2220

tcctctgacg acaagctgga gcagcaacac tccctgttca cccactacag ggacccctgc   2280

cgcctggggc ctggtgagga gaagccgtgg gccatcggta ctctgctgga cacgaacggc   2340

ctgtacgatg aggatgtgtg cacccccgac aacctgcaga aggtcctgga gagtgaggag   2400

ggccgcaggg agtacctggc gtttcccacc agcaagagct cgggccagaa ggggcggaag   2460

gagctgctga agggcaacgg ccggcgcatc gactacatgc tgcatgcaga ggaggggctg   2520

tgcccagact ggaaggccga ggtggaagaa ttcagtttta tcacccagct gtccggcctg   2580

acggaccacc tgccagtagc catgcgactg atggtgtctt cgggggagga ggaggcatag   2640

ctcgacctgc agaagcttgg ccgccatggc ccaacttgtt tattgcagct tataatggtt   2700

acaaataaag caatagcatc acaaatttca caaataaagc atttttttca ctgcattcta   2760

gttgtggttt gtccaaactc atcaatgtat cttatcatgt ctggatcgat cgggaattaa   2820

ttcggcgcag caccatggcc tgaaataacc tctgaaagag gaacttggtt aggtaccttc   2880

tgaggcggaa agaaccagct gtggaatgtg tgtcagttag ggtgtggaaa gtccccaggc   2940

tccccagcag gcagaagtat gcaaagcatg catctcaatt agtcagcaac caggtgtgga   3000

aagtccccag gctccccagc aggcagaact atgcaaagca tgcatctcaa ttagtcagca   3060

accatagtcc cgcccctaac tccgcccatc ccgcccctaa ctccgcccag ttccgcccat   3120

tctccgcccc atggctgact aatttttttt atttatgcag aggccgaggc cgcctcggcc   3180

tctgagctat tccagaagta gtgaggaggc ttttttggag gcctaggctt ttgcaaaaag   3240


ctgttaacag cttggcactg gccgtcgttt tacaacgtcg tgactgggaa aaccctggcg   3300

ttacccaact taatcgcctt gcagcacatc cccccttcgc cagctggcgt aatagcgaag   3360

aggcccgcac cgatcgccct tcccaacagt tgcgtagcct gaatggcgaa tggcgcctga   3420

tgcggtattt tctccttacg catctgtgcg gtatttcaca ccgcatacgt caaagcaacc   3480

atagtacgcg ccctgtagcg gcgcattaag cgcggcgggt gtggtggtta cgcgcagcgt   3540

gaccgctaca cttgccagcg ccctagcgcc cgctcctttc gctttcttcc cttcctttct   3600

cgccacgttc gccggctttc cccgtcaagc tctaaatcgg gggctccctt tagggttccg   3660

atttagtgct ttacggcacc tcgaccccaa aaaacttgat ttgggtgatg gttcacgtag   3720

tgggccatcg ccctgataga cggtttttcg ccctttgacg ttggagtcca cgttctttaa   3780

tagtggactc ttgttccaaa ctggaacaac actcaaccct atctcgggct attcttttga   3840

tttataaggg attttgccga tttcggccta ttggttaaaa aatgagctga tttaacaaaa   3900

atttaacgcg aattttaaca aaatattaac gtttacaatt ttatggtgca ctctcagtac   3960

aatctgctct gatgccgcat agttaagcca actccgctat cgctacgtga ctgggtcatg   4020

gctgcgcccc gacacccgcc aacacccgct gacgcgccct gccgggcttg tctgctcccg   4080

gcatccgctt acagacaagc tgtgaccgtc tccgggagct gcatgtgtca gaggttttca   4140

ccgtcatcac cgaaacgcgc gaggcagtat tcttgaagac gaaagggcct cgtgatacgc   4200

ctatttttat aggttaatgt catgataata atggtttctt agacgtcagg tggcactttt   4260

cggggaaatg tgcgcggaac ccctatttgt ttatttttct aaatacattc aaatatgtat   4320

ccgctcatga gacaataacc ctgataaatg cttcaataat attgaaaaag gaagagtatg   4380

agtattcaac atttccgtgt cgcccttatt cccttttttg cggcattttg ccttcctgtt   4440

tttgctcacc cagaaacgct ggtgaaagta aaagatgctg aagatcagtt gggtgcacga   4500

gtgggttaca tcgaactgga tctcaacagc ggtaagatcc ttgagagttt tcgccccgaa   4560

gaacgttttc caatgatgag cacttttaaa gttctgctat gtggcgcggt attatcccgt   4620

gatgacgccg ggcaagagca actcggtcgc cgcatacact attctcagaa tgacttggtt   4680

gagtactcac cagtcacaga aaagcatctt acggatggca tgacagtaag agaattatgc   4740

agtgctgcca taaccatgag tgataacact gcggccaact tacttctgac aacgatcgga   4800

ggaccgaagg agctaaccgc ttttttgcac aacatggggg atcatgtaac tcgccttgat   4860

cgttgggaac cggagctgaa tgaagccata ccaaacgacg agcgtgacac cacgatgcca   4920

gcagcaatgg caacaacgtt gcgcaaacta ttaactggcg aactacttac tctagcttcc   4980

cggcaacaat taatagactg gatggaggcg gataaagttg caggaccact tctgcgctcg   5040

gcccttccgg ctggctggtt tattgctgat aaatctggag ccggtgagcg tgggtctcgc   5100

ggtatcattg cagcactggg gccagatggt aagccctccc gtatcgtagt tatctacacg   5160

acggggagtc aggcaactat ggatgaacga aatagacaga tcgctgagat aggtgcctca   5220

ctgattaagc attggtaact gtcagaccaa gtttactcat atatacttta gattgattta   5280

aaacttcatt tttaatttaa aaggatctag gtgaagatcc tttttgataa tctcatgacc   5340

aaaatccctt aacgtgagtt ttcgttccac tgagcgtcag accccgtaga aaagatcaaa   5400

ggatcttctt gagatccttt ttttctgcgc gtaatctgct gcttgcaaac aaaaaaacca   5460

ccgctaccag cggtggtttg tttgccggat caagagctac caactctttt tccgaaggta   5520

actggcttca gcagagcgca gataccaaat actgtccttc tagtgtagcc gtagttaggc   5580

caccacttca agaactctgt agcaccgcct acatacctcg ctctgctaat cctgttacca   5640

gtggctgctg ccagtggcga taagtcgtgt cttaccgggt tggactcaag acgatagtta   5700

ccggataacg cgcagcggtc gggctgaacg gggggttcgt gcacacagcc cagcttggag   5760

cgaacgacct acaccgaact gagataccta cagcctgagc attgagaaag cgccacgctt   5820

cccgaaggga gaaaggcgga caggtatccg gtaagcggca gggtcggaac aggagagcgc   5880

acgagggagc ttccaggggg aaacgcctgg tatctttata gtcctgtcgg gtttcgccac   5940

ctctgacttg agcgtcgatt tttgtgatgc tcgtcagggg ggcggagcct atggaaaaac   6000

gccagcaacg cggccttttt acggttcctg gccttttgct ggccttttgc tcacatgttc   6060

tttcctgcgt tatcccctga ttctgtggat aaccgtatta ccgcctttga gtgagctgat   6120

accgctcgcc gcagccgaac gaccgagcgc agcgagtcag tgagcgagga agcggaagag   6180

cgcccaatac gcaaaccgcc tctccccgcg cgttggccga atcattaatc cagctggcac   6240

gacaggtttc ccgactggaa agcgggcagt gagcgcaacg caattaatgt gagttacctc   6300

actcattagg caccccaggc tttacacttt atgcttccgg ctcgtatgtt gtgtggaatt   6360

gtgagcggat aacaatttca cacaggaaac agctatgacc atgattacga attaattcga   6420

gctcgcccga cattgattat tgactagtta ttaatagtaa tcaattacgg ggtcattagt   6480

tcatagccca tatatggagt tccgcgttac ataacttacg gtaaatggcc cgcctggctg   6540

accgcccaac gacccccgcc cattgacgtc aataatgacg tatgttccca tagtaacgcc   6600

aatagggact ttccattgac gtcaatgggt ggagtattta cggtaaactg cccacttggc   6660

agtacatcaa gtgtatca                                                 6678


<210>  12
<211>  8433
<212>  DNA
<213>  Artificial

<220>
<223>  pYES-nSMase3

<400>  12
acggattaga agccgccgag cgggtgacag ccctccgaag gaagactctc ctccgtgcgt     60

cctcgtcttc accggtcgcg ttcctgaaac gcagatgtgc ctcgcgccgc actgctccga    120

acaataaaga ttctacaata ctagctttta tggttatgaa gaggaaaaat tggcagtaac    180

ctggccccac aaaccttcaa atgaacgaat caaattaaca accataggat gataatgcga    240

ttagtttttt agccttattt ctggggtaat taatcagcga agcgatgatt tttgatctat    300

taacagatat ataaatgcaa aaactgcata accactttaa ctaatacttt caacattttc    360

ggtttgtatt acttcttatt caaatgtaat aaaagtatca acaaaaaatt gttaatatac    420

ctctatactt taacgtcaag gagaaaaaac cccggatcgg actactagca gctgtaatac    480

gactcactat agggaatatt aagcttggta ccgagctcgg atccactagt aacggccgcc    540

agtgtgctgg aattctgatg acgactttcg gcgccgtggc ggaatggcgg cttccatctc    600

tgaggcgagc gacgctatgg atcccacagt ggtttgctaa gaaggccatt ttcaactctc    660

cactggaggc tgctatggcg ttccctcacc tgcagcagcc cagctttcta ctggctagcc    720

tgaaagctga ctctataaat aagccctttg cacagcagtg ccaagacttg gttaaagtca    780

ttgaggactt tccagcaaag gagctgcaca ccatcttccc atggctggta gaaagcattt    840

ttggcagcct agatggtgtc ctcgttggct ggaacctccg ctgcttacag gggcgcgtga    900

atcctgtgga gtacagcatc gtgatggaat ttctcgaccc tggtggccca atgatgaagt    960

tggtttataa gcttcaagct gaagactata agttcgactt tcctgtctcc tacttgcctg   1020

gtcctgtgaa ggcgtccatc caggagtgca tcctccctga cagtcctctg taccacaaca   1080

aggtccagtt cacccctact gggggccttg gtctgaactt ggccctgaat ccgttcgagt   1140

attacatatt cttctttgcc ttgagcctca tcactcagaa gccacttcct gtgtccctcc   1200

acgtccgtac ttcagactgt gcctatttca tcctggtgga caggtacctg tcatggttcc   1260

tgcccaccga aggcagtgtg cccccaccac tctcctccag cccagggggg accagcccct   1320

caccacctcc caggacacca gccataccct ttgcttccta tggcctccac cacactagcc   1380

tcctaaagcg acacatctct catcagacgt ctgtgaatgc agaccccgcc tcccacgaga   1440

tctggaggtc agaaactctg ctccaggttt ttgttgaaat gtggcttcat cactattcct   1500

tggagatgta tcaaaaaatg cagtcccctc atgccaagct ggaggttctg cactaccgac   1560

tcagtgtctc cagcgccctc tacagccccg cccaacccag cctccaggcc ctccacgcct   1620

accaagagtc gttcacgcct actgaggagc atgtgttggt ggtgcgcctg ctgctgaagc   1680

acctgcacgc ctttgccaac agcctgaagc cagagcaggc ctcaccctcc gcccactccc   1740

acgccaccag ccccctggag gagttcaaac gggctgctgt cccgaggttc gtccagcaga   1800

aactctacct cttcttgcag cattgctttg gccactggcc cctggacgca tcgttcagag   1860

ctgtcctgga gatgtggctg agctacctgc agccgtggcg gtacgcgcct gacaagcagg   1920

ctccgggcag cgactcccag ccccggtgtg tgtcggagaa atgggcaccc tttgtccagg   1980

agaacctgct gatgtacacc aagttgtttg tgggctttct gaaccgcgcg ctccgcacag   2040

acctggtcag ccccaagcac gcgctcatgg tgttccgagt ggccaaagtc tttgcccagc   2100


ccaacctggc tgagatgatt cagaaaggtg agcagctatt cctggagcca gagctggtca   2160

tcccccaccg ccagcaccga ctcttcacgg cccccacatt cactgggagc ttcctgtcac   2220

cctggccacc agcggtcact gatgcctcct tcaaggtgaa gagccacgtc tacagcctgg   2280

agggccagga ctgcaagtac accccgatgt ttgggcccga ggcccgcacc ctggtcctgc   2340

gcctcgctca gctcatcaca caggccaaac acacagccaa gtccatctcc gaccagtgtg   2400

cggagagccc ggctggccac tccttcctct catggctggg ctttagctcc atggacacca   2460

atggctccta cacagccaac gacctggacg agatggggca agacagtgtc cggaagacag   2520

atgaatacct ggagaaggcc ctggagtacc tgcgccagat attccggctc agcgaagcgc   2580

agctcaggca gttcacactc gccttgggca ccacccagga tgagaatgga aaaaagcaac   2640

tccccgactg catcgtgggt gaggacggac tcatccttac gcccctgggg cggtaccaga   2700

tcatcaatgg gctgcgaagg tttgaaattg agtaccaggg ggacccggag ctgcagccca   2760

tccggagcta tgagatcgcc agcttggtcc gcacactctt taggctgtcg tctgccatca   2820

accacagatt tgcaggacag atggcggctc tgtgttcccg ggatgacttc ctcggcagct   2880

tctgtcgcta ccacctcaca gaacctgggc tggccagcag gcacctgctg agccctgtgg   2940

ggcggaggca ggtggccggc cacacccgcg gccccaggct cagcctgcgc ttcctgggca   3000

gttaccggac gctggtctcg ctgctgctgg ccttcttcgt ggcctctctg ttctgcgtcg   3060

ggcccctccc atgcacgctg ctgctcaccc tgggctatgt cctctacgcc tctgccatga   3120

cactgctgac cgagcggggg aagctgcacc agccctgacg tcgagcatgc atctagaggg   3180

ccgcatcatg taattagtta tgtcacgctt acattcacgc cctcccccca catccgctct   3240

aaccgaaaag gaaggagtta gacaacctga agtctaggtc cctatttatt tttttatagt   3300

tatgttagta ttaagaacgt tatttatatt tcaaattttt cttttttttc tgtacagacg   3360

cgtgtacgca tgtaacatta tactgaaaac cttgcttgag aaggttttgg gacgctcgaa   3420

ggctttaatt tgcggccctg cattaatgaa tcggccaacg cgcggggaga ggcggtttgc   3480

gtattgggcg ctcttccgct tcctcgctca ctgactcgct gcgctcggtc gttcggctgc   3540

ggcgagcggt atcagctcac tcaaaggcgg taatacggtt atccacagaa tcaggggata   3600

acgcaggaaa gaacatgtga gcaaaaggcc agcaaaagcc caggaaccgt aaaaaggccg   3660

cgttgctggc gtttttccat aggctccgcc cccctgacga gcatcacaaa aatcgacgct   3720

caagtcagag gtggcgaaac ccgacaggac tataaagata ccaggcgttt ccccctggaa   3780

gctccctcgt gcgctctcct gttccgaccc tgccgcttac cggatacctg tccgcctttc   3840

tcccttcggg aagcgtggcg ctttctcata gctcacgctg taggtatctc agttcggtgt   3900

aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc cgttcagccc gaccgctgcg   3960

ccttatccgg taactatcgt cttgagtcca acccggtaag acacgactta tcgccactgg   4020

cagcagccac tggtaacagg attagcagag cgaggtatgt aggcggtgct acagagttct   4080

tgaagtggtg gcctaactac ggctacacta gaaggacagt atttggtatc tgcgctctgc   4140

tgaagccagt taccttcgga aaaagagttg gtagctcttg atccggcaaa caaaccaccg   4200

ctggtagcgg tggttttttt gtttgcaagc agcagattac gcgcagaaaa aaaggatctc   4260

aagaagatcc tttgatcttt tctacggggt ctgacgctca gtggaacgaa aactcacgtt   4320

aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac ctagatcctt ttaaattaaa   4380

aatgaagttt taaatcaatc taaagtatat atgagtaaac ttggtctgac agttaccaat   4440

gcttaatcag tgaggcacct atctcagcga tctgtctatt tcgttcatcc atagttgcct   4500

gactccccgt cgtgtagata actacgatac gggagcgctt accatctggc cccagtgctg   4560

caatgatacc gcgagaccca cgctcaccgg ctccagattt atcagcaata aaccagccag   4620

ccggaagggc cgagcgcaga agtggtcctg caactttatc cgcctccatt cagtctatta   4680

attgttgccg ggaagctaga gtaagtagtt cgccagttaa tagtttgcgc aacgttgttg   4740

gcattgctac aggcatcgtg gtgtcactct cgtcgtttgg tatggcttca ttcagctccg   4800

gttcccaacg atcaaggcga gttacatgat cccccatgtt gtgcaaaaaa gcggttagct   4860

ccttcggtcc tccgatcgtt gtcagaagta agttggccgc agtgttatca ctcatggtta   4920

tggcagcact gcataattct cttactgtca tgccatccgt aagatgcttt tctgtgactg   4980

gtgagtactc aaccaagtca ttctgagaat agtgtatgcg gcgaccgagt tgctcttgcc   5040

cggcgtcaat acgggataat agtgtatcac atagcagaac tttaaaagtg ctcatcattg   5100

gaaaacgttc ttcggggcga aaactctcaa ggatcttacc gctgttgaga tccagttcga   5160

tgtaacccac tcgtgcaccc aactgatctt cagcatcttt tactttcacc agcgtttctg   5220

ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg aataagggcg acacggaaat   5280

gttgaatact catactcttc ctttttcaat gggtaataac tgatataatt aaattgaagc   5340

tctaatttgt gagtttagta tacatgcatt tacttataat acagtttttt agttttgctg   5400

gccgcatctt ctcaaatatg cttcccagcc tgcttttctg taacgttcac cctctacctt   5460

agcatccctt ccctttgcaa atagtcctct tccaacaata ataatgtcag atcctgtaga   5520

gaccacatca tccacggttc tatactgttg acccaatgcg tctcccttgt catctaaacc   5580

cacaccgggt gtcataatca accaatcgta accttcatct cttccaccca tgtctctttg   5640

agcaataaag ccgataacaa aatctttgtc gctcttcgca atgtcaacag tacccttagt   5700

atattctcca gtagataggg agcccttgca tgacaattct gctaacatca aaaggcctct   5760

aggttccttt gttacttctt ctgccgcctg cttcaaaccg ctaacaatac ctgggcccac   5820

cacaccgtgt gcattcgtaa tgtctgccca ttctgctatt ctgtatacac ccgcagagta   5880

ctgcaatttg actgtattac caatgtcagc aaattttctg tcttcgaaga gtaaaaaatt   5940


gtacttggcg gataatgcct ttagcggctt aactgtgccc tccatggaaa aatcagtcaa   6000

gatatccaca tgtgttttta gtaaacaaat tttgggacct aatgcttcaa ctaactccag   6060

taattccttg gtggtacgaa catccaatga agcacacaag tttgtttgct tttcgtgcat   6120

gatattaaat agcttggcag caacaggact aggatgagta gcagcacgtt ccttatatgt   6180

agctttcgac atgatttatc ttcgtttcct gcaggttttt gttctgtgca gttgggttaa   6240

gaatactggg caatttcatg tttcttcaac actacatatg cgtatatata ccaatctaag   6300

tctgtgctcc ttccttcgtt cttccttctg ttcggagatt accgaatcaa aaaaatttca   6360

aagaaaccga aatcaaaaaa aagaataaaa aaaaaatgat gaattgaatt gaaaagctag   6420

cttatcgatg ataagctgtc aaagatgaga attaattcca cggactatag actatactag   6480

atactccgtc tactgtacga tacacttccg ctcaggtcct tgtcctttaa cgaggcctta   6540

ccactctttt gttactctat tgatccagct cagcaaaggc agtgtgatct aagattctat   6600

cttcgcgatg tagtaaaact agctagaccg agaaagagac tagaaatgca aaaggcactt   6660

ctacaatggc tgccatcatt attatccgat gtgacgctgc agcttctcaa tgatattcga   6720

atacgctttg aggagataca gcctaatatc cgacaaactg ttttacagat ttacgatcgt   6780

acttgttacc catcattgaa ttttgaacat ccgaacctgg gagttttccc tgaaacagat   6840

agtatatttg aacctgtata ataatatata gtctagcgct ttacggaaga caatgtatgt   6900

atttcggttc ctggagaaac tattgcatct attgcatagg taatcttgca cgtcgcatcc   6960

ccggttcatt ttctgcgttt ccatcttgca cttcaatagc atatctttgt taacgaagca   7020

tctgtgcttc attttgtaga acaaaaatgc aacgcgagag cgctaatttt tcaaacaaag   7080

aatctgagct gcatttttac agaacagaaa tgcaacgcga aagcgctatt ttaccaacga   7140

agaatctgtg cttcattttt gtaaaacaaa aatgcaacgc gacgagagcg ctaatttttc   7200

aaacaaagaa tctgagctgc atttttacag aacagaaatg caacgcgaga gcgctatttt   7260

accaacaaag aatctatact tcttttttgt tctacaaaaa tgcatcccga gagcgctatt   7320

tttctaacaa agcatcttag attacttttt ttctcctttg tgcgctctat aatgcagtct   7380

cttgataact ttttgcactg taggtccgtt aaggttagaa gaaggctact ttggtgtcta   7440

ttttctcttc cataaaaaaa gcctgactcc acttcccgcg tttactgatt actagcgaag   7500

ctgcgggtgc attttttcaa gataaaggca tccccgatta tattctatac cgatgtggat   7560

tgcgcatact ttgtgaacag aaagtgatag cgttgatgat tcttcattgg tcagaaaatt   7620

atgaacggtt tcttctattt tgtctctata tactacgtat aggaaatgtt tacattttcg   7680

tattgttttc gattcactct atgaatagtt cttactacaa tttttttgtc taaagagtaa   7740

tactagagat aaacataaaa aatgtagagg tcgagtttag atgcaagttc aaggagcgaa   7800

aggtggatgg gtaggttata tagggatata gcacagagat atatagcaaa gagatacttt   7860

tgagcaatgt ttgtggaagc ggtattcgca atgggaagct ccaccccggt tgataatcag   7920

aaaagcccca aaaacaggaa gattgtataa gcaaatattt aaattgtaaa cgttaatatt   7980

ttgttaaaat tcgcgttaaa tttttgttaa atcagctcat tttttaacga atagcccgaa   8040

atcggcaaaa tcccttataa atcaaaagaa tagaccgaga tagggttgag tgttgttcca   8100

gtttccaaca agagtccact attaaagaac gtggactcca acgtcaaagg gcgaaaaagg   8160

gtctatcagg gcgatggccc actacgtgaa ccatcaccct aatcaagttt tttggggtcg   8220

aggtgccgta aagcagtaaa tcggaagggt aaacggatgc ccccatttag agcttgacgg   8280

ggaaagccgg cgaacgtggc gagaaaggaa gggaagaaag cgaaaggagc gggggctagg   8340

gcggtgggaa gtgtaggggt cacgctgggc gtaaccacca cacccgccgc gcttaatggg   8400

gcgctacagg gcgcgtgggg atgatccact agt                                8433


<210>  13
<211>  7766
<212>  DNA
<213>  Artificial

<220>
<223>  pYES-nSMase2

<400>  13
acggattaga agccgccgag cgggtgacag ccctccgaag gaagactctc ctccgtgcgt     60

cctcgtcttc accggtcgcg ttcctgaaac gcagatgtgc ctcgcgccgc actgctccga    120

acaataaaga ttctacaata ctagctttta tggttatgaa gaggaaaaat tggcagtaac    180

ctggccccac aaaccttcaa atgaacgaat caaattaaca accataggat gataatgcga    240

ttagtttttt agccttattt ctggggtaat taatcagcga agcgatgatt tttgatctat    300

taacagatat ataaatgcaa aaactgcata accactttaa ctaatacttt caacattttc    360

ggtttgtatt acttcttatt caaatgtaat aaaagtatca acaaaaaatt gttaatatac    420

ctctatactt taacgtcaag gagaaaaaac cccggatcgg actactagca gctgtaatac    480

gactcactat agggaatatt aagcttggta ccgagctcgg atccatggtt ttgtacacga    540

ccccctttcc taacagctgt ctgtccgccc tgcactgtgt gtcctgggcc cttatctttc    600

catgctactg gctggtggac cggctcgctg cctccttcat acccaccacc tacgagaagc    660

gccagcgggc agacgacccg tgctgcctgc agctgctctg cactgccctc ttcacgccca    720

tctacctggc cctcctggtg gcctcgctgc cctttgcgtt tctcggcttt ctcttctggt    780

ccccactgca gtcggcccgc cggccctaca tctattcacg gctggaagac aagggcctgg    840

ccggtggggc agccctgctc agtgaatgga agggcacggg gcctggcaaa agcttctgct    900

ttgccactgc caacgtctgc ctcctgcccg actcactcgc cagggtcaac aaccttttta    960

acacccaagc gcgggccaag gagatcgggc agagaatccg caatggggcc gcccggcccc   1020

agatcaaaat ttacatcgac tcccccacca atacctccat cagcgccgct agcttcagca   1080

gcctggtgtc accacagggc ggcgatgggg tggcccgggc cgtccccggg agcattaaga   1140

ggacagcctc tgtggagtac aagggtgacg gtgggcggca ccccggtgac gaggctgcca   1200

acggcccagc ctctggggac cctgtcgaca gcagcagccc ggaggatgcc tgcatcgtgc   1260

gcatcggtgg cgaggagggc ggccggccac ctgaagctga cgaccctgtg cctgggggcc   1320

aggccaggaa cggagctggc gggggcccaa ggggccagac gcccaaccat aatcagcagg   1380

acggggattc agggagcctg ggcagcccct cggcctcccg ggagtccctg gtgaaggggc   1440

gagctgggcc agacaccagt gccagcgggg agccaggtgc caacagcaag ctcctgtaca   1500

aggcctcggt ggtgaagaag gcggctgcac gcaggaggcg gcaccccgac gaggccttcg   1560

accatgaggt ctccgccttc ttccccgcca acctggactt cctgtgcctg caggaggtgt   1620

ttgacaagcg agcagccacc aaattgaaag agcagctgca cggctacttc gagtacatcc   1680

tgtacgacgt cggggtctac ggctgccagg gctgctgcag cttcaagtgt ctcaacagcg   1740

gcctcctctt tgccagccgc taccccatca tggacgtggc ctatcactgt taccccaaca   1800

agtgtaacga cgatgccctg gcctctaagg gagctctgtt tctcaaggtg caggtgggaa   1860

gcacacctca ggaccaaaga atcgtcgggt acatcgcctg cacacacctg catgccccac   1920

aagaggacag cgccatccgg tgtgggcagc tggacctgct tcaggactgg ctggctgatt   1980

tccgaaaatc tacctcctcg tccagcgcag ccaaccccga ggagctggtg gcatttgacg   2040

tcgtctgtgg agatttcaac tttgataact gctcctctga cgacaagctg gagcagcaac   2100

actccctgtt cacccactac agggacccct gccgcctggg gcctggtgag gagaagccgt   2160

gggccatcgg tactctgctg gacacgaacg gcctgtacga tgaggatgtg tgcacccccg   2220

acaacctgca gaaggtcctg gagagtgagg agggccgcag ggagtacctg gcgtttccca   2280

ccagcaagag ctcgggccag aaggggcgga aggagctgct gaagggcaac ggccggcgca   2340

tcgactacat gctgcatgca gaggaggggc tgtgcccaga ctggaaggcc gaggtggaag   2400

aattcagttt tatcacccag ctgtccggcc tgacggacca cctgccagta gccatgcgac   2460

tgatggtgtc ttcgggggag gaggaggcat agctcgagca tgcatctaga gggccgcatc   2520

atgtaattag ttatgtcacg cttacattca cgccctcccc ccacatccgc tctaaccgaa   2580

aaggaaggag ttagacaacc tgaagtctag gtccctattt atttttttat agttatgtta   2640

gtattaagaa cgttatttat atttcaaatt tttctttttt ttctgtacag acgcgtgtac   2700

gcatgtaaca ttatactgaa aaccttgctt gagaaggttt tgggacgctc gaaggcttta   2760

atttgcggcc ctgcattaat gaatcggcca acgcgcgggg agaggcggtt tgcgtattgg   2820

gcgctcttcc gcttcctcgc tcactgactc gctgcgctcg gtcgttcggc tgcggcgagc   2880

ggtatcagct cactcaaagg cggtaatacg gttatccaca gaatcagggg ataacgcagg   2940

aaagaacatg tgagcaaaag gccagcaaaa gcccaggaac cgtaaaaagg ccgcgttgct   3000

ggcgtttttc cataggctcc gcccccctga cgagcatcac aaaaatcgac gctcaagtca   3060


gaggtggcga aacccgacag gactataaag ataccaggcg tttccccctg gaagctccct   3120

cgtgcgctct cctgttccga ccctgccgct taccggatac ctgtccgcct ttctcccttc   3180

gggaagcgtg gcgctttctc atagctcacg ctgtaggtat ctcagttcgg tgtaggtcgt   3240

tcgctccaag ctgggctgtg tgcacgaacc ccccgttcag cccgaccgct gcgccttatc   3300

cggtaactat cgtcttgagt ccaacccggt aagacacgac ttatcgccac tggcagcagc   3360

cactggtaac aggattagca gagcgaggta tgtaggcggt gctacagagt tcttgaagtg   3420

gtggcctaac tacggctaca ctagaaggac agtatttggt atctgcgctc tgctgaagcc   3480

agttaccttc ggaaaaagag ttggtagctc ttgatccggc aaacaaacca ccgctggtag   3540

cggtggtttt tttgtttgca agcagcagat tacgcgcaga aaaaaaggat ctcaagaaga   3600

tcctttgatc ttttctacgg ggtctgacgc tcagtggaac gaaaactcac gttaagggat   3660

tttggtcatg agattatcaa aaaggatctt cacctagatc cttttaaatt aaaaatgaag   3720

ttttaaatca atctaaagta tatatgagta aacttggtct gacagttacc aatgcttaat   3780

cagtgaggca cctatctcag cgatctgtct atttcgttca tccatagttg cctgactccc   3840

cgtcgtgtag ataactacga tacgggagcg cttaccatct ggccccagtg ctgcaatgat   3900

accgcgagac ccacgctcac cggctccaga tttatcagca ataaaccagc cagccggaag   3960

ggccgagcgc agaagtggtc ctgcaacttt atccgcctcc attcagtcta ttaattgttg   4020

ccgggaagct agagtaagta gttcgccagt taatagtttg cgcaacgttg ttggcattgc   4080

tacaggcatc gtggtgtcac tctcgtcgtt tggtatggct tcattcagct ccggttccca   4140

acgatcaagg cgagttacat gatcccccat gttgtgcaaa aaagcggtta gctccttcgg   4200

tcctccgatc gttgtcagaa gtaagttggc cgcagtgtta tcactcatgg ttatggcagc   4260

actgcataat tctcttactg tcatgccatc cgtaagatgc ttttctgtga ctggtgagta   4320

ctcaaccaag tcattctgag aatagtgtat gcggcgaccg agttgctctt gcccggcgtc   4380

aatacgggat aatagtgtat cacatagcag aactttaaaa gtgctcatca ttggaaaacg   4440

ttcttcgggg cgaaaactct caaggatctt accgctgttg agatccagtt cgatgtaacc   4500

cactcgtgca cccaactgat cttcagcatc ttttactttc accagcgttt ctgggtgagc   4560

aaaaacagga aggcaaaatg ccgcaaaaaa gggaataagg gcgacacgga aatgttgaat   4620

actcatactc ttcctttttc aatgggtaat aactgatata attaaattga agctctaatt   4680

tgtgagttta gtatacatgc atttacttat aatacagttt tttagttttg ctggccgcat   4740

cttctcaaat atgcttccca gcctgctttt ctgtaacgtt caccctctac cttagcatcc   4800

cttccctttg caaatagtcc tcttccaaca ataataatgt cagatcctgt agagaccaca   4860

tcatccacgg ttctatactg ttgacccaat gcgtctccct tgtcatctaa acccacaccg   4920

ggtgtcataa tcaaccaatc gtaaccttca tctcttccac ccatgtctct ttgagcaata   4980

aagccgataa caaaatcttt gtcgctcttc gcaatgtcaa cagtaccctt agtatattct   5040

ccagtagata gggagccctt gcatgacaat tctgctaaca tcaaaaggcc tctaggttcc   5100

tttgttactt cttctgccgc ctgcttcaaa ccgctaacaa tacctgggcc caccacaccg   5160

tgtgcattcg taatgtctgc ccattctgct attctgtata cacccgcaga gtactgcaat   5220

ttgactgtat taccaatgtc agcaaatttt ctgtcttcga agagtaaaaa attgtacttg   5280

gcggataatg cctttagcgg cttaactgtg ccctccatgg aaaaatcagt caagatatcc   5340

acatgtgttt ttagtaaaca aattttggga cctaatgctt caactaactc cagtaattcc   5400

ttggtggtac gaacatccaa tgaagcacac aagtttgttt gcttttcgtg catgatatta   5460

aatagcttgg cagcaacagg actaggatga gtagcagcac gttccttata tgtagctttc   5520

gacatgattt atcttcgttt cctgcaggtt tttgttctgt gcagttgggt taagaatact   5580

gggcaatttc atgtttcttc aacactacat atgcgtatat ataccaatct aagtctgtgc   5640

tccttccttc gttcttcctt ctgttcggag attaccgaat caaaaaaatt tcaaagaaac   5700

cgaaatcaaa aaaaagaata aaaaaaaaat gatgaattga attgaaaagc tagcttatcg   5760

atgataagct gtcaaagatg agaattaatt ccacggacta tagactatac tagatactcc   5820

gtctactgta cgatacactt ccgctcaggt ccttgtcctt taacgaggcc ttaccactct   5880

tttgttactc tattgatcca gctcagcaaa ggcagtgtga tctaagattc tatcttcgcg   5940

atgtagtaaa actagctaga ccgagaaaga gactagaaat gcaaaaggca cttctacaat   6000

ggctgccatc attattatcc gatgtgacgc tgcagcttct caatgatatt cgaatacgct   6060

ttgaggagat acagcctaat atccgacaaa ctgttttaca gatttacgat cgtacttgtt   6120

acccatcatt gaattttgaa catccgaacc tgggagtttt ccctgaaaca gatagtatat   6180

ttgaacctgt ataataatat atagtctagc gctttacgga agacaatgta tgtatttcgg   6240

ttcctggaga aactattgca tctattgcat aggtaatctt gcacgtcgca tccccggttc   6300

attttctgcg tttccatctt gcacttcaat agcatatctt tgttaacgaa gcatctgtgc   6360

ttcattttgt agaacaaaaa tgcaacgcga gagcgctaat ttttcaaaca aagaatctga   6420

gctgcatttt tacagaacag aaatgcaacg cgaaagcgct attttaccaa cgaagaatct   6480

gtgcttcatt tttgtaaaac aaaaatgcaa cgcgacgaga gcgctaattt ttcaaacaaa   6540

gaatctgagc tgcattttta cagaacagaa atgcaacgcg agagcgctat tttaccaaca   6600

aagaatctat acttcttttt tgttctacaa aaatgcatcc cgagagcgct atttttctaa   6660

caaagcatct tagattactt tttttctcct ttgtgcgctc tataatgcag tctcttgata   6720

actttttgca ctgtaggtcc gttaaggtta gaagaaggct actttggtgt ctattttctc   6780

ttccataaaa aaagcctgac tccacttccc gcgtttactg attactagcg aagctgcggg   6840

tgcatttttt caagataaag gcatccccga ttatattcta taccgatgtg gattgcgcat   6900


actttgtgaa cagaaagtga tagcgttgat gattcttcat tggtcagaaa attatgaacg   6960

gtttcttcta ttttgtctct atatactacg tataggaaat gtttacattt tcgtattgtt   7020

ttcgattcac tctatgaata gttcttacta caattttttt gtctaaagag taatactaga   7080

gataaacata aaaaatgtag aggtcgagtt tagatgcaag ttcaaggagc gaaaggtgga   7140

tgggtaggtt atatagggat atagcacaga gatatatagc aaagagatac ttttgagcaa   7200

tgtttgtgga agcggtattc gcaatgggaa gctccacccc ggttgataat cagaaaagcc   7260

ccaaaaacag gaagattgta taagcaaata tttaaattgt aaacgttaat attttgttaa   7320

aattcgcgtt aaatttttgt taaatcagct cattttttaa cgaatagccc gaaatcggca   7380

aaatccctta taaatcaaaa gaatagaccg agatagggtt gagtgttgtt ccagtttcca   7440

acaagagtcc actattaaag aacgtggact ccaacgtcaa agggcgaaaa agggtctatc   7500

agggcgatgg cccactacgt gaaccatcac cctaatcaag ttttttgggg tcgaggtgcc   7560

gtaaagcagt aaatcggaag ggtaaacgga tgcccccatt tagagcttga cggggaaagc   7620

cggcgaacgt ggcgagaaag gaagggaaga aagcgaaagg agcgggggct agggcggtgg   7680

gaagtgtagg ggtcacgctg ggcgtaacca ccacacccgc cgcgcttaat ggggcgctac   7740

agggcgcgtg gggatgatcc actagt                                        7766


<210>  14
<211>  5487
<212>  DNA
<213>  Artificial

<220>
<223>  AdCGI; bicistronic adenoviral vector encoding EGFP

<400>  14
catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt     60

ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt    120

gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg    180

gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag    240

taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga    300

agtgaaatct gaataatttt gtgttactca tagcgcgtaa tatttgtcta gggccgcggg    360

gactttgacc gtttacgtgg agactcgccc aggtgttttt ctcaggtgtt ttccgcgttc    420

cgggtcaaag ttggcgtttt attattatag tcagtaatag taatcaatta cggggtcatt    480

agttcatagc ccatatatgg agttccgcgt tacataactt acggtaaatg gcccgcctgg    540

ctgaccgccc aacgaccccc gcccattgac gtcaataatg acgtatgttc ccatagtaac    600

gccaataggg actttccatt gacgtcaatg ggtggagtat ttacggtaaa ctgcccactt    660

ggcagtacat caagtgtatc atatgccaag tacgccccct attgacgtca atgacggtaa    720

atggcccgcc tggcattatg cccagtacat gaccttatgg gactttccta cttggcagta    780

catctacgta ttagtcatcg ctattaccat ggtgatgcgg ttttggcagt acatcaatgg    840

gcgtggatag cggtttgact cacggggatt tccaagtctc caccccattg acgtcaatgg    900

gagtttgttt tggcaccaaa atcaacggga ctttccaaaa tgtcgtaaca actccgcccc    960

attgacgcaa atgggcggta ggcgtgtacg gtgggaggtc tatataagca gagctggttt   1020

agtgaaccgt cagatccgct agcgctaccg gtcgccacca tggtgagcaa gggcgaggag   1080

ctgttcaccg gggtggtgcc catcctggtc gagctggacg gcgacgtaaa cggccacaag   1140

ttcagcgtgt ccggcgaggg cgagggcgat gccacctacg gcaagctgac cctgaagttc   1200

atctgcacca ccggcaagct gcccgtgccc tggcccaccc tcgtgaccac cctgacctac   1260

ggcgtgcagt gcttcagccg ctaccccgac cacatgaagc agcacgactt cttcaagtcc   1320

gccatgcccg aaggctacgt ccaggagcgc accatcttct tcaaggacga cggcaactac   1380

aagacccgcg ccgaggtgaa gttcgagggc gacaccctgg tgaaccgcat cgagctgaag   1440

ggcatcgact tcaaggagga cggcaacatc ctggggcaca agctggagta caactacaac   1500

agccacaacg tctatatcat ggccgacaag cagaagaacg gcatcaaggt gaacttcaag   1560

atccgccaca acatcgagga cggcagcgtg cagctcgccg accactacca gcagaacacc   1620


cccatcggcg acggccccgt gctgctgccc gacaaccact acctgagcac ccagtccgcc   1680

ctgagcaaag accccaacga gaagcgcgat cacatggtcc tgctggagtt cgtgaccgcc   1740

gccgggatca ctctcggcat ggacgagctg tacaagtgtg gcggctagta ctccggtatt   1800

gcggtaccct tgtacgcctg ttttatactc ccttcccgta acttagacgc acaaaaccaa   1860

gttcaataga agggggtaca aaccagtacc accacgaaca agcacttctg tttccccggt   1920

gatgtcgtat agactgcttg cgtggttgaa agcgacggat ccgttatccg cttatgtact   1980

tcgagaagcc cagtaccacc tcggaatctt cgatgcgttg cgctcagcac tcaaccccag   2040

agtgtagctt aggctgatga gtctggacat ccctcaccgg tgacggtggt ccaggctgcg   2100

ttggcggcct acctatggct aacgccatgg gacgctagtt gtgaacaagg tgtgaagagc   2160

ctattgagct acataagaat cctccggccc ctgaatgcgg ctaatcccaa cctcggagca   2220

ggtggtcaca aaccagtgat tggcctgtcg taacgcgcaa gtccgtggcg gaaccgacta   2280

ctttgggtgt ccgtgtttcc ttttatttta ttgtggctgc ttatggtgac aatcacagat   2340

tgttatcata aagcgaattg gataggatca agcttatcga taccgtcgac ctcgagctca   2400

agcttcgaat tctgcagtcg acggtaccgc gggcccggga tccaccggat ctagataact   2460

gatcataatc agccatacca catttgtaga ggttttactt gctttaaaaa acctcccaca   2520

cctccccctg aacctgaaac ataaaatgaa tgcaattgtt gttgttaact tgtttattgc   2580

agcttataat ggttacaaat aaagcaatag catcacaaat ttcacaaata aagcattttt   2640

ttcactgcat tctagttgtg gtttgtccaa actcatcaat gtatcttatc atgtctggat   2700

catcgatcca taacttcgta taatgtatgc tatacgaagt tatccagatc tggttctata   2760

gtgtcaccta aatcgtatgt gtatgataca taaggttatg tattaattgt agccgcgttc   2820

taacgacaat atgtccatag ggcccctacg tcacccgccc cgttcccacg ccccgcgcca   2880

cgtcacaaac tccaccccct cattatcata ttggcttcaa tccaaaataa ggtatattat   2940

tgatgatggc cgcagcggcc cctggcgtaa tagcgaagag gcccgcaccg atcgcccttc   3000

ccaacagttg cgcagcctga atggcgaatg ggacgcgccc tgtagcggcg cattaagcgc   3060

ggcgggtgtg gtggttacgc gcagcgtgac cgctacactt gccagcgccc tagcgcccgc   3120

tcctttcgct ttcttccctt cctttctcgc cacgttcgcc ggctttcccc gtcaagctct   3180

aaatcggggg ctccctttag ggttccgatt tagtgcttta cggcacctcg accccaaaaa   3240

acttgattag ggtgatggtt cacgtagtgg gccatcgccc tgatagacgg tttttcgccc   3300

tttgacgttg gagtccacgt tctttaatag tggactcttg ttccaaactg gaacaacact   3360

caaccctatc tcggtctatt cttttgattt ataagggatt ttgccgattt cggcctattg   3420

gttaaaaaat gagctgattt aacaaaaatt taacgcgaat tttaacaaaa tattaacgct   3480

tacaatttag gtggcacttt tcggggaaat gtgcgcggaa cccctatttg tttatttttc   3540

taaatacatt caaatatgta tccgctcatg agacaataac cctgataaat gcttcaataa   3600

tattgaaaaa ggaagagtat gagtattcaa catttccgtg tcgcccttat tccctttttt   3660

gcggcatttt gccttcctgt ttttgctcac ccagaaacgc tggtgaaagt aaaagatgct   3720

gaagatcagt tgggtgcacg agtgggttac atcgaactgg atctcaacag cggtaagatc   3780

cttgagagtt ttcgccccga agaacgtttt ccaatgatga gcacttttaa agttctgcta   3840

tgtggcgcgg tattatcccg tattgacgcc gggcaagagc aactcggtcg ccgcatacac   3900

tattctcaga atgacttggt tgagtactca ccagtcacag aaaagcatct tacggatggc   3960

atgacagtaa gagaattatg cagtgctgcc ataaccatga gtgataacac tgcggccaac   4020

ttacttctga caacgatcgg aggaccgaag gagctaaccg cttttttgca caacatgggg   4080

gatcatgtaa ctcgccttga tcgttgggaa ccggagctga atgaagccat accaaacgac   4140

gagcgtgaca ccacgatgcc tgtagcaatg gcaacaacgt tgcgcaaact attaactggc   4200

gaactactta ctctagcttc ccggcaacaa ttaatagact ggatggaggc ggataaagtt   4260

gcaggaccac ttctgcgctc ggcccttccg gctggctggt ttattgctga taaatctgga   4320

gccggtgagc gtgggtctcg cggtatcatt gcagcactgg ggccagatgg taagccctcc   4380

cgtatcgtag ttatctacac gacggggagt caggcaacta tggatgaacg aaatagacag   4440

atcgctgaga taggtgcctc actgattaag cattggtaac tgtcagacca agtttactca   4500

tatatacttt agattgattt aaaacttcat ttttaattta aaaggatcta ggtgaagatc   4560

ctttttgata atctcatgac caaaatccct taacgtgagt tttcgttcca ctgagcgtca   4620

gaccccgtag aaaagatcaa aggatcttct tgagatcctt tttttctgcg cgtaatctgc   4680

tgcttgcaaa caaaaaaacc accgctacca gcggtggttt gtttgccgga tcaagagcta   4740

ccaactcttt ttccgaaggt aactggcttc agcagagcgc agataccaaa tactgtcctt   4800

ctagtgtagc cgtagttagg ccaccacttc aagaactctg tagcaccgcc tacatacctc   4860

gctctgctaa tcctgttacc agtggctgct gccagtggcg ataagtcgtg tcttaccggg   4920

ttggactcaa gacgatagtt accggataag gcgcagcggt cgggctgaac ggggggttcg   4980

tgcacacagc ccagcttgga gcgaacgacc tacaccgaac tgagatacct acagcgtgag   5040

ctatgagaaa gcgccacgct tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc   5100

agggtcggaa caggagagcg cacgagggag cttccagggg gaaacgcctg gtatctttat   5160

agtcctgtcg ggtttcgcca cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg   5220

gggcggagcc tatggaaaaa cgccagcaac gcggcctttt tacggttcct ggccttttgc   5280

tggccttttg ctcacatgtt ctttcctgcg ttatcccctg attctgtgga taaccgtatt   5340

accgcctttg agtgagctga taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca   5400

gtgagcgagg aagcggaaga gcgcccaata cgcaaaccgc ctctccccgc gcgttggccg   5460


attcattaat gcaggggccg ctgcggc                                       5487


<210>  15
<211>  7318
<212>  DNA
<213>  Artificial

<220>
<223>  pGFP-nSMase3

<400>  15
tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct ggcattatgc     60

ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat tagtcatcgc    120

tattaccatg gtgatgcggt tttggcagta catcaatggg cgtggatagc ggtttgactc    180

acggggattt ccaagtctcc accccattga cgtcaatggg agtttgtttt ggcaccaaaa    240

tcaacgggac tttccaaaat gtcgtaacaa ctccgcccca ttgacgcaaa tgggcggtag    300

gcgtgtacgg tgggaggtct atataagcag agctggttta gtgaaccgtc agatccgcta    360

gcgctaccgg tcgccaccat ggtgagcaag ggcgaggagc tgttcaccgg ggtggtgccc    420

atcctggtcg agctggacgg cgacgtaaac ggccacaagt tcagcgtgtc cggcgagggc    480

gagggcgatg ccacctacgg caagctgacc ctgaagttca tctgcaccac cggcaagctg    540

cccgtgccct ggcccaccct cgtgaccacc ctgacctacg gcgtgcagtg cttcagccgc    600

taccccgacc acatgaagca gcacgacttc ttcaagtccg ccatgcccga aggctacgtc    660

caggagcgca ccatcttctt caaggacgac ggcaactaca agacccgcgc cgaggtgaag    720

ttcgagggcg acaccctggt gaaccgcatc gagctgaagg gcatcgactt caaggaggac    780

ggcaacatcc tggggcacaa gctggagtac aactacaaca gccacaacgt ctatatcatg    840

gccgacaagc agaagaacgg catcaaggtg aacttcaaga tccgccacaa catcgaggac    900

ggcagcgtgc agctcgccga ccactaccag cagaacaccc ccatcggcga cggccccgtg    960

ctgctgcccg acaaccacta cctgagcacc cagtccgccc tgagcaaaga ccccaacgag   1020

aagcgcgatc acatggtcct gctggagttc gtgaccgccg ccgggatcac tctcggcatg   1080

gacgagctgt acaagtactc agatctcgag atgacgactt tcggcgccgt ggcggaatgg   1140

cggcttccat ctctgaggcg agcgacgcta tggatcccac agtggtttgc taagaaggcc   1200

attttcaact ctccactgga ggctgctatg gcgttccctc acctgcagca gcccagcttt   1260

ctactggcta gcctgaaagc tgactctata aataagccct ttgcacagca gtgccaagac   1320

ttggttaaag tcattgagga ctttccagca aaggagctgc acaccatctt cccatggctg   1380

gtagaaagca tttttggcag cctagatggt gtcctcgttg gctggaacct ccgctgctta   1440

caggggcgcg tgaatcctgt ggagtacagc atcgtgatgg aatttctcga ccctggtggc   1500

ccaatgatga agttggttta taagcttcaa gctgaagact ataagttcga ctttcctgtc   1560

tcctacttgc ctggtcctgt gaaggcgtcc atccaggagt gcatcctccc tgacagtcct   1620

ctgtaccaca acaaggtcca gttcacccct actgggggcc ttggtctgaa cttggccctg   1680


aatccgttcg agtattacat attcttcttt gccttgagcc tcatcactca gaagccactt   1740

cctgtgtccc tccacgtccg tacttcagac tgtgcctatt tcatcctggt ggacaggtac   1800

ctgtcatggt tcctgcccac cgaaggcagt gtgcccccac cactctcctc cagcccaggg   1860

gggaccagcc cctcaccacc tcccaggaca ccagccatac cctttgcttc ctatggcctc   1920

caccacacta gcctcctaaa gcgacacatc tctcatcaga cgtctgtgaa tgcagacccc   1980

gcctcccacg agatctggag gtcagaaact ctgctccagg tttttgttga aatgtggctt   2040

catcactatt ccttggagat gtatcaaaaa atgcagtccc ctcatgccaa gctggaggtt   2100

ctgcactacc gactcagtgt ctccagcgcc ctctacagcc ccgcccaacc cagcctccag   2160

gccctccacg cctaccaaga gtcgttcacg cctactgagg agcatgtgtt ggtggtgcgc   2220

ctgctgctga agcacctgca cgcctttgcc aacagcctga agccagagca ggcctcaccc   2280

tccgcccact cccacgccac cagccccctg gaggagttca aacgggctgc tgtcccgagg   2340

ttcgtccagc agaaactcta cctcttcttg cagcattgct ttggccactg gcccctggac   2400

gcatcgttca gagctgtcct ggagatgtgg ctgagctacc tgcagccgtg gcggtacgcg   2460

cctgacaagc aggctccggg cagcgactcc cagccccggt gtgtgtcgga gaaatgggca   2520

ccctttgtcc aggagaacct gctgatgtac accaagttgt ttgtgggctt tctgaaccgc   2580

gcgctccgca cagacctggt cagccccaag cacgcgctca tggtgttccg agtggccaaa   2640

gtctttgccc agcccaacct ggctgagatg attcagaaag gtgagcagct attcctggag   2700

ccagagctgg tcatccccca ccgccagcac cgactcttca cggcccccac attcactggg   2760

agcttcctgt caccctggcc accagcggtc actgatgcct ccttcaaggt gaagagccac   2820

gtctacagcc tggagggcca ggactgcaag tacaccccga tgtttgggcc cgaggcccgc   2880

accctggtcc tgcgcctcgc tcagctcatc acacaggcca aacacacagc caagtccatc   2940

tccgaccagt gtgcggagag cccggctggc cactccttcc tctcatggct gggctttagc   3000

tccatggaca ccaatggctc ctacacagcc aacgacctgg acgagatggg gcaagacagt   3060

gtccggaaga cagatgaata cctggagaag gccctggagt acctgcgcca gatattccgg   3120

ctcagcgaag cgcagctcag gcagttcaca ctcgccttgg gcaccaccca ggatgagaat   3180

ggaaaaaagc aactccccga ctgcatcgtg ggtgaggacg gactcatcct tacgcccctg   3240

gggcggtacc agatcatcaa tgggctgcga aggtttgaaa ttgagtacca gggggacccg   3300

gagctgcagc ccatccggag ctatgagatc gccagcttgg tccgcacact ctttaggctg   3360

tcgtctgcca tcaaccacag atttgcagga cagatggcgg ctctgtgttc ccgggatgac   3420

ttcctcggca gcttctgtcg ctaccacctc acagaacctg ggctggccag caggcacctg   3480

ctgagccctg tggggcggag gcaggtggcc ggccacaccc gcggccccag gctcagcctg   3540

cgcttcctgg gcagttaccg gacgctggtc tcgctgctgc tggccttctt cgtggcctct   3600

ctgttctgcg tcgggcccct cccatgcacg ctgctgctca ccctgggcta tgtcctctac   3660

gcctctgcca tgacactgct gaccgagcgg gggaagctgc accagccctg agaattctgc   3720

agtcgacggt accgcgggcc cgggatccac cggatctaga taactgatca taatcagcca   3780

taccacattt gtagaggttt tacttgcttt aaaaaacctc ccacacctcc ccctgaacct   3840

gaaacataaa atgaatgcaa ttgttgttgt taacttgttt attgcagctt ataatggtta   3900

caaataaagc aatagcatca caaatttcac aaataaagca tttttttcac tgcattctag   3960

ttgtggtttg tccaaactca tcaatgtatc ttaacgcgta aattgtaagc gttaatattt   4020

tgttaaaatt cgcgttaaat ttttgttaaa tcagctcatt ttttaaccaa taggccgaaa   4080

tcggcaaaat cccttataaa tcaaaagaat agaccgagat agggttgagt gttgttccag   4140

tttggaacaa gagtccacta ttaaagaacg tggactccaa cgtcaaaggg cgaaaaaccg   4200

tctatcaggg cgatggccca ctacgtgaac catcacccta atcaagtttt ttggggtcga   4260

ggtgccgtaa agcactaaat cggaacccta aagggagccc ccgatttaga gcttgacggg   4320

gaaagccggc gaacgtggcg agaaaggaag ggaagaaagc gaaaggagcg ggcgctaggg   4380

cgctggcaag tgtagcggtc acgctgcgcg taaccaccac acccgccgcg cttaatgcgc   4440

cgctacaggg cgcgtcaggt ggcacttttc ggggaaatgt gcgcggaacc cctatttgtt   4500

tatttttcta aatacattca aatatgtatc cgctcatgag acaataaccc tgataaatgc   4560

ttcaataata ttgaaaaagg aagagtcctg aggcggaaag aaccagctgt ggaatgtgtg   4620

tcagttaggg tgtggaaagt ccccaggctc cccagcaggc agaagtatgc aaagcatgca   4680

tctcaattag tcagcaacca ggtgtggaaa gtccccaggc tccccagcag gcagaagtat   4740

gcaaagcatg catctcaatt agtcagcaac catagtcccg cccctaactc cgcccatccc   4800

gcccctaact ccgcccagtt ccgcccattc tccgccccat ggctgactaa ttttttttat   4860

ttatgcagag gccgaggccg cctcggcctc tgagctattc cagaagtagt gaggaggctt   4920

ttttggaggc ctaggctttt gcaaagatcg atcaagagac aggatgagga tcgtttcgca   4980

tgattgaaca agatggattg cacgcaggtt ctccggccgc ttgggtggag aggctattcg   5040

gctatgactg ggcacaacag acaatcggct gctctgatgc cgccgtgttc cggctgtcag   5100

cgcaggggcg cccggttctt tttgtcaaga ccgacctgtc cggtgccctg aatgaactgc   5160

aagacgaggc agcgcggcta tcgtggctgg ccacgacggg cgttccttgc gcagctgtgc   5220

tcgacgttgt cactgaagcg ggaagggact ggctgctatt gggcgaagtg ccggggcagg   5280

atctcctgtc atctcacctt gctcctgccg agaaagtatc catcatggct gatgcaatgc   5340

ggcggctgca tacgcttgat ccggctacct gcccattcga ccaccaagcg aaacatcgca   5400

tcgagcgagc acgtactcgg atggaagccg gtcttgtcga tcaggatgat ctggacgaag   5460

agcatcaggg gctcgcgcca gccgaactgt tcgccaggct caaggcgagc atgcccgacg   5520

gcgaggatct cgtcgtgacc catggcgatg cctgcttgcc gaatatcatg gtggaaaatg   5580

gccgcttttc tggattcatc gactgtggcc ggctgggtgt ggcggaccgc tatcaggaca   5640

tagcgttggc tacccgtgat attgctgaag agcttggcgg cgaatgggct gaccgcttcc   5700

tcgtgcttta cggtatcgcc gctcccgatt cgcagcgcat cgccttctat cgccttcttg   5760

acgagttctt ctgagcggga ctctggggtt cgaaatgacc gaccaagcga cgcccaacct   5820

gccatcacga gatttcgatt ccaccgccgc cttctatgaa aggttgggct tcggaatcgt   5880

tttccgggac gccggctgga tgatcctcca gcgcggggat ctcatgctgg agttcttcgc   5940

ccaccctagg gggaggctaa ctgaaacacg gaaggagaca ataccggaag gaacccgcgc   6000

tatgacggca ataaaaagac agaataaaac gcacggtgtt gggtcgtttg ttcataaacg   6060

cggggttcgg tcccagggct ggcactctgt cgatacccca ccgagacccc attggggcca   6120

atacgcccgc gtttcttcct tttccccacc ccacccccca agttcgggtg aaggcccagg   6180

gctcgcagcc aacgtcgggg cggcaggccc tgccatagcc tcaggttact catatatact   6240

ttagattgat ttaaaacttc atttttaatt taaaaggatc taggtgaaga tcctttttga   6300

taatctcatg accaaaatcc cttaacgtga gttttcgttc cactgagcgt cagaccccgt   6360

agaaaagatc aaaggatctt cttgagatcc tttttttctg cgcgtaatct gctgcttgca   6420

aacaaaaaaa ccaccgctac cagcggtggt ttgtttgccg gatcaagagc taccaactct   6480

ttttccgaag gtaactggct tcagcagagc gcagatacca aatactgtcc ttctagtgta   6540

gccgtagtta ggccaccact tcaagaactc tgtagcaccg cctacatacc tcgctctgct   6600

aatcctgtta ccagtggctg ctgccagtgg cgataagtcg tgtcttaccg ggttggactc   6660

aagacgatag ttaccggata aggcgcagcg gtcgggctga acggggggtt cgtgcacaca   6720

gcccagcttg gagcgaacga cctacaccga actgagatac ctacagcgtg agctatgaga   6780

aagcgccacg cttcccgaag ggagaaaggc ggacaggtat ccggtaagcg gcagggtcgg   6840

aacaggagag cgcacgaggg agcttccagg gggaaacgcc tggtatcttt atagtcctgt   6900

cgggtttcgc cacctctgac ttgagcgtcg atttttgtga tgctcgtcag gggggcggag   6960

cctatggaaa aacgccagca acgcggcctt tttacggttc ctggcctttt gctggccttt   7020

tgctcacatg ttctttcctg cgttatcccc tgattctgtg gataaccgta ttaccgccat   7080

gcattagtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt   7140

tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc   7200

cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac   7260

gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatca     7318


<210>  16
<211>  11
<212>  PRT
<213>  Bos taurus

<400>  16

Lys Gly Leu Pro Tyr Leu Glu Gln Leu Phe Arg 
1               5                   10      


<210>  17
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  17

Lys Ala Leu Glu Tyr Leu Arg Gln Ile Phe Arg 
1               5                   10      


<210>  18
<211>  178
<212>  PRT
<213>  Homo sapiens

<400>  18

Cys Leu Gln Gly Arg Val Asn Pro Val Glu Tyr Ser Ile Val Met Glu 
1               5                   10                  15      


Phe Leu Asp Pro Gly Gly Pro Met Met Lys Leu Val Tyr Lys Leu Gln 
            20                  25                  30          


Ala Glu Asp Tyr Lys Phe Asp Phe Pro Val Ser Tyr Leu Pro Gly Pro 
        35                  40                  45              


Val Lys Ala Ser Ile Gln Glu Cys Ile Leu Pro Asp Ser Pro Leu Tyr 
    50                  55                  60                  


His Asn Lys Val Gln Phe Thr Pro Thr Gly Gly Leu Gly Leu Asn Leu 
65                  70                  75                  80  


Ala Leu Asn Pro Phe Glu Tyr Tyr Ile Phe Phe Phe Ala Leu Ser Leu 
                85                  90                  95      


Ile Thr Gln Lys Pro Leu Pro Val Ser Leu His Val Arg Thr Ser Asp 
            100                 105                 110         


Cys Ala Tyr Phe Ile Leu Val Asp Arg Tyr Leu Ser Trp Phe Leu Pro 
        115                 120                 125             


Thr Glu Gly Ser Val Pro Pro Pro Leu Ser Ser Ser Pro Gly Gly Thr 
    130                 135                 140                 


Ser Pro Ser Pro Pro Pro Arg Thr Pro Ala Ile Pro Phe Ala Ser Tyr 
145                 150                 155                 160 


Gly Leu His His Thr Ser Leu Leu Lys Arg His Ile Ser His Gln Thr 
                165                 170                 175     


Ser Val 
        


<210>  19
<211>  69
<212>  PRT
<213>  Homo sapiens

<400>  19

Tyr Gln Lys Met Gln Ser Pro His Ala Lys Leu Glu Val Leu His Tyr 
1               5                   10                  15      


Arg Leu Ser Val Ser Ser Ala Leu Tyr Ser Pro Ala Gln Pro Ser Leu 
            20                  25                  30          


Gln Ala Leu His Ala Tyr Gln Glu Ser Phe Thr Pro Thr Glu Glu His 
        35                  40                  45              


Val Leu Val Val Arg Leu Leu Leu Lys His Leu His Ala Phe Ala Asn 
    50                  55                  60                  


Ser Leu Lys Pro Glu 
65                  


<210>  20
<211>  51
<212>  PRT
<213>  Homo sapiens

<400>  20

Lys Arg Ala Ala Val Pro Arg Phe Val Gln Gln Lys Leu Tyr Leu Phe 
1               5                   10                  15      


Leu Gln His Cys Phe Gly His Trp Pro Leu Asp Ala Ser Phe Arg Ala 
            20                  25                  30          


Val Leu Glu Met Trp Leu Ser Tyr Leu Gln Pro Trp Arg Tyr Ala Pro 
        35                  40                  45              


Asp Lys Gln 
    50      


<210>  21
<211>  79
<212>  PRT
<213>  Homo sapiens

<400>  21

Val Ser Glu Lys Trp Ala Pro Phe Val Gln Glu Asn Leu Leu Met Tyr 
1               5                   10                  15      


Thr Lys Leu Phe Val Gly Phe Leu Asn Arg Ala Leu Arg Thr Asp Leu 
            20                  25                  30          


Val Ser Pro Lys His Ala Leu Met Val Phe Arg Val Ala Lys Val Phe 
        35                  40                  45              


Ala Gln Pro Asn Leu Ala Glu Met Ile Gln Lys Gly Glu Gln Leu Phe 
    50                  55                  60                  


Leu Glu Pro Glu Leu Val Ile Pro His Arg Gln His Arg Leu Phe 
65                  70                  75                  


<210>  22
<211>  47
<212>  PRT
<213>  Homo sapiens

<400>  22

Ser Phe Lys Val Lys Ser His Val Tyr Ser Leu Glu Gly Gln Asp Cys 
1               5                   10                  15      


Lys Tyr Thr Pro Met Phe Gly Pro Glu Ala Arg Thr Leu Val Leu Arg 
            20                  25                  30          


Leu Ala Gln Leu Ile Thr Gln Ala Lys His Thr Ala Lys Ser Ile 
        35                  40                  45          


<210>  23
<211>  41
<212>  PRT
<213>  Homo sapiens

<400>  23

Thr Ala Asn Asp Leu Asp Glu Met Gly Gln Asp Ser Val Arg Lys Thr 
1               5                   10                  15      


Asp Glu Tyr Leu Glu Lys Ala Leu Glu Tyr Leu Arg Gln Ile Phe Arg 
            20                  25                  30          


Leu Ser Glu Ala Gln Leu Arg Gln Phe 
        35                  40      


<210>  24
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  24

Leu Ile Leu Thr Pro Leu Gly Arg Tyr Gln Ile Ile Asn Gly Leu Arg 
1               5                   10                  15      


Arg Phe Glu Ile Glu Tyr Gln Gly Asp Pro Glu Leu Gln Pro Ile Arg 
            20                  25                  30          


Ser Tyr Glu Ile Ala Ser Leu Val Arg Thr Leu Phe Arg Leu Ser Ser 
        35                  40                  45              


Ala Ile Asn His Arg Phe Ala Gly Gln Met Ala Ala Leu Cys Ser Arg 
    50                  55                  60                  


Asp Asp Phe Leu Gly Ser Phe Cys Arg Tyr His Leu Thr Glu Pro Gly 
65                  70                  75                  80  


Leu Ala Ser Arg His Leu Leu Ser Pro Val Gly Arg Arg Gln Val Ala 
                85                  90                  95      


Gly His Thr Arg Gly Pro Arg Leu Ser Leu Arg Phe Leu Gly Ser Tyr 
            100                 105                 110         


Arg Thr Leu Val Ser Leu Leu Leu Ala Phe Phe Val Ala Ser Leu Phe 
        115                 120                 125             


Cys Val Gly Pro 
    130         


<210>  25
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  forward primer for nSMase3

<400>  25
ggaattctga tgacgacttt cggcg                                           25


<210>  26
<211>  25
<212>  DNA
<213>  artificial

<220>
<223>  reverse primer nSMase3

<400>  26
gtcgacgtca gggctggtgc agctt                                           25


<210>  27
<211>  25
<212>  DNA
<213>  artificial

<220>
<223>  forward primer nSMase2

<400>  27
gggatccatg gttttgtaca cgacc                                           25


<210>  28
<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  reverse primer nSMase2

<400>  28
cctcgagcta tgcctcctcc tccc                                            24


<210>  29
<211>  8078
<212>  DNA
<213>  Artificial

<220>
<223>  AdCGIpnSMase3; AdCGI vector encoding nSMase3

<400>  29
catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt     60

ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt    120

gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg    180

gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag    240

taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga    300

agtgaaatct gaataatttt gtgttactca tagcgcgtaa tatttgtcta gggccgcggg    360

gactttgacc gtttacgtgg agactcgccc aggtgttttt ctcaggtgtt ttccgcgttc    420

cgggtcaaag ttggcgtttt attattatag tcagtaatag taatcaatta cggggtcatt    480

agttcatagc ccatatatgg agttccgcgt tacataactt acggtaaatg gcccgcctgg    540

ctgaccgccc aacgaccccc gcccattgac gtcaataatg acgtatgttc ccatagtaac    600

gccaataggg actttccatt gacgtcaatg ggtggagtat ttacggtaaa ctgcccactt    660

ggcagtacat caagtgtatc atatgccaag tacgccccct attgacgtca atgacggtaa    720

atggcccgcc tggcattatg cccagtacat gaccttatgg gactttccta cttggcagta    780

catctacgta ttagtcatcg ctattaccat ggtgatgcgg ttttggcagt acatcaatgg    840

gcgtggatag cggtttgact cacggggatt tccaagtctc caccccattg acgtcaatgg    900

gagtttgttt tggcaccaaa atcaacggga ctttccaaaa tgtcgtaaca actccgcccc    960

attgacgcaa atgggcggta ggcgtgtacg gtgggaggtc tatataagca gagctggttt   1020

agtgaaccgt cagatccgct agcgctaccg gtcgccacca tggtgagcaa gggcgaggag   1080

ctgttcaccg gggtggtgcc catcctggtc gagctggacg gcgacgtaaa cggccacaag   1140

ttcagcgtgt ccggcgaggg cgagggcgat gccacctacg gcaagctgac cctgaagttc   1200

atctgcacca ccggcaagct gcccgtgccc tggcccaccc tcgtgaccac cctgacctac   1260

ggcgtgcagt gcttcagccg ctaccccgac cacatgaagc agcacgactt cttcaagtcc   1320

gccatgcccg aaggctacgt ccaggagcgc accatcttct tcaaggacga cggcaactac   1380

aagacccgcg ccgaggtgaa gttcgagggc gacaccctgg tgaaccgcat cgagctgaag   1440

ggcatcgact tcaaggagga cggcaacatc ctggggcaca agctggagta caactacaac   1500

agccacaacg tctatatcat ggccgacaag cagaagaacg gcatcaaggt gaacttcaag   1560

atccgccaca acatcgagga cggcagcgtg cagctcgccg accactacca gcagaacacc   1620

cccatcggcg acggccccgt gctgctgccc gacaaccact acctgagcac ccagtccgcc   1680

ctgagcaaag accccaacga gaagcgcgat cacatggtcc tgctggagtt cgtgaccgcc   1740

gccgggatca ctctcggcat ggacgagctg tacaagtgtg gcggctagta ctccggtatt   1800

gcggtaccct tgtacgcctg ttttatactc ccttcccgta acttagacgc acaaaaccaa   1860

gttcaataga agggggtaca aaccagtacc accacgaaca agcacttctg tttccccggt   1920

gatgtcgtat agactgcttg cgtggttgaa agcgacggat ccgttatccg cttatgtact   1980

tcgagaagcc cagtaccacc tcggaatctt cgatgcgttg cgctcagcac tcaaccccag   2040

agtgtagctt aggctgatga gtctggacat ccctcaccgg tgacggtggt ccaggctgcg   2100

ttggcggcct acctatggct aacgccatgg gacgctagtt gtgaacaagg tgtgaagagc   2160

ctattgagct acataagaat cctccggccc ctgaatgcgg ctaatcccaa cctcggagca   2220

ggtggtcaca aaccagtgat tggcctgtcg taacgcgcaa gtccgtggcg gaaccgacta   2280

ctttgggtgt ccgtgtttcc ttttatttta ttgtggctgc ttatggtgac aatcacagat   2340

tgttatcata aagcgaattg gataggatca agcttatcga taccgtcgac ctcgagatga   2400

cgactttcgg cgccgtggcg gaatggcggc ttccatctct gaggcgagcg acgctatgga   2460

tcccacagtg gtttgctaag aaggccattt tcaactctcc actggaggct gctatggcgt   2520

tccctcacct gcagcagccc agctttctac tggctagcct gaaagctgac tctataaata   2580

agccctttgc acagcagtgc caagacttgg ttaaagtcat tgaggacttt ccagcaaagg   2640

agctgcacac catcttccca tggctggtag aaagcatttt tggcagccta gatggtgtcc   2700

tcgttggctg gaacctccgc tgcttacagg ggcgcgtgaa tcctgtggag tacagcatcg   2760

tgatggaatt tctcgaccct ggtggcccaa tgatgaagtt ggtttataag cttcaagctg   2820

aagactataa gttcgacttt cctgtctcct acttgcctgg tcctgtgaag gcgtccatcc   2880

aggagtgcat cctccctgac agtcctctgt accacaacaa ggtccagttc acccctactg   2940

ggggccttgg tctgaacttg gccctgaatc cgttcgagta ttacatattc ttctttgcct   3000

tgagcctcat cactcagaag ccacttcctg tgtccctcca cgtccgtact tcagactgtg   3060

cctatttcat cctggtggac aggtacctgt catggttcct gcccaccgaa ggcagtgtgc   3120

ccccaccact ctcctccagc ccagggggga ccagcccctc accacctccc aggacaccag   3180

ccataccctt tgcttcctat ggcctccacc acactagcct cctaaagcga cacatctctc   3240

atcagacgtc tgtgaatgca gaccccgcct cccacgagat ctggaggtca gaaactctgc   3300

tccaggtttt tgttgaaatg tggcttcatc actattcctt ggagatgtat caaaaaatgc   3360

agtcccctca tgccaagctg gaggttctgc actaccgact cagtgtctcc agcgccctct   3420

acagccccgc ccaacccagc ctccaggccc tccacgccta ccaagagtcg ttcacgccta   3480

ctgaggagca tgtgttggtg gtgcgcctgc tgctgaagca cctgcacgcc tttgccaaca   3540

gcctgaagcc agagcaggcc tcaccctccg cccactccca cgccaccagc cccctggagg   3600

agttcaaacg ggctgctgtc ccgaggttcg tccagcagaa actctacctc ttcttgcagc   3660

attgctttgg ccactggccc ctggacgcat cgttcagagc tgtcctggag atgtggctga   3720

gctacctgca gccgtggcgg tacgcgcctg acaagcaggc tccgggcagc gactcccagc   3780

cccggtgtgt gtcggagaaa tgggcaccct ttgtccagga gaacctgctg atgtacacca   3840

agttgtttgt gggctttctg aaccgcgcgc tccgcacaga cctggtcagc cccaagcacg   3900

cgctcatggt gttccgagtg gccaaagtct ttgcccagcc caacctggct gagatgattc   3960

agaaaggtga gcagctattc ctggagccag agctggtcat cccccaccgc cagcaccgac   4020

tcttcacggc ccccacattc actgggagct tcctgtcacc ctggccacca gcggtcactg   4080

atgcctcctt caaggtgaag agccacgtct acagcctgga gggccaggac tgcaagtaca   4140

ccccgatgtt tgggcccgag gcccgcaccc tggtcctgcg cctcgctcag ctcatcacac   4200

aggccaaaca cacagccaag tccatctccg accagtgtgc ggagagcccg gctggccact   4260

ccttcctctc atggctgggc tttagctcca tggacaccaa tggctcctac acagccaacg   4320

acctggacga gatggggcaa gacagtgtcc ggaagacaga tgaatacctg gagaaggccc   4380

tggagtacct gcgccagata ttccggctca gcgaagcgca gctcaggcag ttcacactcg   4440

ccttgggcac cacccaggat gagaatggaa aaaagcaact ccccgactgc atcgtgggtg   4500

aggacggact catccttacg cccctggggc ggtaccagat catcaatggg ctgcgaaggt   4560

ttgaaattga gtaccagggg gacccggagc tgcagcccat ccggagctat gagatcgcca   4620

gcttggtccg cacactcttt aggctgtcgt ctgccatcaa ccacagattt gcaggacaga   4680

tggcggctct gtgttcccgg gatgacttcc tcggcagctt ctgtcgctac cacctcacag   4740

aacctgggct ggccagcagg cacctgctga gccctgtggg gcggaggcag gtggccggcc   4800

acacccgcgg ccccaggctc agcctgcgct tcctgggcag ttaccggacg ctggtctcgc   4860

tgctgctggc cttcttcgtg gcctctctgt tctgcgtcgg gcccctccca tgcacgctgc   4920

tgctcaccct gggctatgtc ctctacgcct ctgccatgac actgctgacc gagcggggga   4980

agctgcacca gccctgagaa ttctgcagtc gacggtaccg cgggcccggg atccaccgga   5040

tctagataac tgatcataat cagccatacc acatttgtag aggttttact tgctttaaaa   5100

aacctcccac acctccccct gaacctgaaa cataaaatga atgcaattgt tgttgttaac   5160

ttgtttattg cagcttataa tggttacaaa taaagcaata gcatcacaaa tttcacaaat   5220

aaagcatttt tttcactgca ttctagttgt ggtttgtcca aactcatcaa tgtatcttat   5280

catgtctgga tcatcgatcc ataacttcgt ataatgtatg ctatacgaag ttatccagat   5340

ctggttctat agtgtcacct aaatcgtatg tgtatgatac ataaggttat gtattaattg   5400

tagccgcgtt ctaacgacaa tatgtccata gggcccctac gtcacccgcc ccgttcccac   5460

gccccgcgcc acgtcacaaa ctccaccccc tcattatcat attggcttca atccaaaata   5520

aggtatatta ttgatgatgg ccgcagcggc ccctggcgta atagcgaaga ggcccgcacc   5580

gatcgccctt cccaacagtt gcgcagcctg aatggcgaat gggacgcgcc ctgtagcggc   5640

gcattaagcg cggcgggtgt ggtggttacg cgcagcgtga ccgctacact tgccagcgcc   5700

ctagcgcccg ctcctttcgc tttcttccct tcctttctcg ccacgttcgc cggctttccc   5760

cgtcaagctc taaatcgggg gctcccttta gggttccgat ttagtgcttt acggcacctc   5820

gaccccaaaa aacttgatta gggtgatggt tcacgtagtg ggccatcgcc ctgatagacg   5880

gtttttcgcc ctttgacgtt ggagtccacg ttctttaata gtggactctt gttccaaact   5940

ggaacaacac tcaaccctat ctcggtctat tcttttgatt tataagggat tttgccgatt   6000

tcggcctatt ggttaaaaaa tgagctgatt taacaaaaat ttaacgcgaa ttttaacaaa   6060

atattaacgc ttacaattta ggtggcactt ttcggggaaa tgtgcgcgga acccctattt   6120

gtttattttt ctaaatacat tcaaatatgt atccgctcat gagacaataa ccctgataaa   6180

tgcttcaata atattgaaaa aggaagagta tgagtattca acatttccgt gtcgccctta   6240

ttcccttttt tgcggcattt tgccttcctg tttttgctca cccagaaacg ctggtgaaag   6300

taaaagatgc tgaagatcag ttgggtgcac gagtgggtta catcgaactg gatctcaaca   6360

gcggtaagat ccttgagagt tttcgccccg aagaacgttt tccaatgatg agcactttta   6420

aagttctgct atgtggcgcg gtattatccc gtattgacgc cgggcaagag caactcggtc   6480

gccgcataca ctattctcag aatgacttgg ttgagtactc accagtcaca gaaaagcatc   6540

ttacggatgg catgacagta agagaattat gcagtgctgc cataaccatg agtgataaca   6600

ctgcggccaa cttacttctg acaacgatcg gaggaccgaa ggagctaacc gcttttttgc   6660

acaacatggg ggatcatgta actcgccttg atcgttggga accggagctg aatgaagcca   6720

taccaaacga cgagcgtgac accacgatgc ctgtagcaat ggcaacaacg ttgcgcaaac   6780

tattaactgg cgaactactt actctagctt cccggcaaca attaatagac tggatggagg   6840

cggataaagt tgcaggacca cttctgcgct cggcccttcc ggctggctgg tttattgctg   6900

ataaatctgg agccggtgag cgtgggtctc gcggtatcat tgcagcactg gggccagatg   6960

gtaagccctc ccgtatcgta gttatctaca cgacggggag tcaggcaact atggatgaac   7020

gaaatagaca gatcgctgag ataggtgcct cactgattaa gcattggtaa ctgtcagacc   7080

aagtttactc atatatactt tagattgatt taaaacttca tttttaattt aaaaggatct   7140

aggtgaagat cctttttgat aatctcatga ccaaaatccc ttaacgtgag ttttcgttcc   7200

actgagcgtc agaccccgta gaaaagatca aaggatcttc ttgagatcct ttttttctgc   7260

gcgtaatctg ctgcttgcaa acaaaaaaac caccgctacc agcggtggtt tgtttgccgg   7320

atcaagagct accaactctt tttccgaagg taactggctt cagcagagcg cagataccaa   7380

atactgtcct tctagtgtag ccgtagttag gccaccactt caagaactct gtagcaccgc   7440

ctacatacct cgctctgcta atcctgttac cagtggctgc tgccagtggc gataagtcgt   7500

gtcttaccgg gttggactca agacgatagt taccggataa ggcgcagcgg tcgggctgaa   7560

cggggggttc gtgcacacag cccagcttgg agcgaacgac ctacaccgaa ctgagatacc   7620

tacagcgtga gctatgagaa agcgccacgc ttcccgaagg gagaaaggcg gacaggtatc   7680

cggtaagcgg cagggtcgga acaggagagc gcacgaggga gcttccaggg ggaaacgcct   7740

ggtatcttta tagtcctgtc gggtttcgcc acctctgact tgagcgtcga tttttgtgat   7800

gctcgtcagg ggggcggagc ctatggaaaa acgccagcaa cgcggccttt ttacggttcc   7860

tggccttttg ctggcctttt gctcacatgt tctttcctgc gttatcccct gattctgtgg   7920

ataaccgtat taccgccttt gagtgagctg ataccgctcg ccgcagccga acgaccgagc   7980

gcagcgagtc agtgagcgag gaagcggaag agcgcccaat acgcaaaccg cctctccccg   8040

cgcgttggcc gattcattaa tgcaggggcc gctgcggc                           8078


<210>  30
<211>  60
<212>  DNA
<213>  Artificial

<220>
<223>  sense strand of shRNA against nSMase3

<400>  30
gatctcccct gctgatgtac accaagttca agagacttgg tgtacatcag caggttttta     60


<210>  31
<211>  60
<212>  DNA
<213>  Artificial

<220>
<223>  antisense strand of shRNA against nSMase3

<400>  31
agcttaaaaa cctgctgatg tacaccaagt ctcttgaact tggtgtacat cagcagggga     60


<210>  32
<211>  2935
<212>  DNA
<213>  Artificial

<220>
<223>  pENTRY-shnSMase3; vector encoding shRNA to nSMase3

<400>  32
ctttcctgcg ttatcccctg attctgtgga taaccgtatt accgcctttg agtgagctga     60

taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg aagcggaaga    120

gcgcccaata cgcaaaccgc ctctccccgc gcgttggccg attcattaat gcagctggca    180

cgacaggttt cccgactgga aagcgggcag tgagcgcaac gcaattaata cgcgtaccgc    240

tagccaggaa gagtttgtag aaacgcaaaa aggccatccg tcaggatggc cttctgctta    300

gtttgatgcc tggcagttta tggcgggcgt cctgcccgcc accctccggg ccgttgcttc    360

acaacgttca aatccgctcc cggcggattt gtcctactca ggagagcgtt caccgacaaa    420

caacagataa aacgaaaggc ccagtcttcc gactgagcct ttcgttttat ttgatgcctg    480

gcagttccct actctcgcgt taacgctagc atggatgttt tcccagtcac gacgttgtaa    540

aacgacggcc agtcttaagc tcgggcccca aataatgatt ttattttgac tgatagtgac    600

ctgttcgttg caacaaattg atgagcaatg cttttttata atgccaactt tgtacaaaaa    660

agcaggctag cattcctgca gttctagaac tagtggatcc cccgggctgc aggaattcga    720

acgctgacgt catcaacccg ctccaaggaa tcgcgggccc agtgtcacta ggcgggaaca    780

cccagcgcgc gtgcgccctg gcaggaagat ggctgtgagg gacaggggag tggcgccctg    840

caatatttgc atgtcgctat gtgttctggg aaatcaccat aaacgtgaaa tgtctttgga    900

tttgggaatc ttataagttc tgtatgagac cacagatctc ccctgctgat gtacaccaag    960

ttcaagagac ttggtgtaca tcagcaggtt tttaagctta tcgataccgt cgacctcgag   1020

ggggggcccg gtaccaatcg atttaaatag ctcgctagca cccagctttc ttgtacaaag   1080

ttggcattat aagaaagcat tgcttatcaa tttgttgcaa cgaacaggtc actatcagtc   1140

aaaataaaat cattatttgc catccagctg atatccccta tagtgagtcg tattacatgg   1200

tcatagctgt ttcctggcag ctctggcccg tgtctcaaaa tctctgatgt tacattgcac   1260

aagataaaat aatatcatca tgaacaataa aactgtctgc ttacataaac agtaatacaa   1320

ggggtgttat gagccatatt caacgggaaa cgtcgaggcc gcgattaaat tccaacatgg   1380

atgctgattt atatgggtat aaatgggctc gcgataatgt cgggcaatca ggtgcgacaa   1440

tctatcgctt gtatgggaag cccgatgcgc cagagttgtt tctgaaacat ggcaaaggta   1500

gcgttgccaa tgatgttaca gatgagatgg tcagactaaa ctggctgacg gaatttatgc   1560

ctcttccgac catcaagcat tttatccgta ctcctgatga tgcatggtta ctcaccactg   1620

cgatccccgg aaaaacagca ttccaggtat tagaagaata tcctgattca ggtgaaaata   1680

ttgttgatgc gctggcagtg ttcctgcgcc ggttgcattc gattcctgtt tgtaattgtc   1740

cttttaacag cgatcgcgta tttcgtctcg ctcaggcgca atcacgaatg aataacggtt   1800

tggttgatgc gagtgatttt gatgacgagc gtaatggctg gcctgttgaa caagtctgga   1860

aagaaatgca taaacttttg ccattctcac cggattcagt cgtcactcat ggtgatttct   1920

cacttgataa ccttattttt gacgagggga aattaatagg ttgtattgat gttggacgag   1980

tcggaatcgc agaccgatac caggatcttg ccatcctatg gaactgcctc ggtgagtttt   2040

ctccttcatt acagaaacgg ctttttcaaa aatatggtat tgataatcct gatatgaata   2100

aattgcagtt tcatttgatg ctcgatgagt ttttctaatc agaattggtt aattggttgt   2160

aacactggca gagcattacg ctgacttgac gggacggcgc aagctcatga ccaaaatccc   2220

ttaacgtgag ttacgcgtcg ttccactgag cgtcagaccc cgtagaaaag atcaaaggat   2280

cttcttgaga tccttttttt ctgcgcgtaa tctgctgctt gcaaacaaaa aaaccaccgc   2340

taccagcggt ggtttgtttg ccggatcaag agctaccaac tctttttccg aaggtaactg   2400

gcttcagcag agcgcagata ccaaatactg ttcttctagt gtagccgtag ttaggccacc   2460

acttcaagaa ctctgtagca ccgcctacat acctcgctct gctaatcctg ttaccagtgg   2520

ctgctgccag tggcgataag tcgtgtctta ccgggttgga ctcaagacga tagttaccgg   2580

ataaggcgca gcggtcgggc tgaacggggg gttcgtgcac acagcccagc ttggagcgaa   2640

cgacctacac cgaactgaga tacctacagc gtgagctatg agaaagcgcc acgcttcccg   2700

aagggagaaa ggcggacagg tatccggtaa gcggcagggt cggaacagga gagcgcacga   2760

gggagcttcc agggggaaac gcctggtatc tttatagtcc tgtcgggttt cgccacctct   2820

gacttgagcg tcgatttttg tgatgctcgt caggggggcg gagcctatgg aaaaacgcca   2880

gcaacgcggc ctttttacgg ttcctggcct tttgctggcc ttttgctcac atgtt        2935


<210>  33
<211>  6869
<212>  DNA
<213>  Artificial

<220>
<223>  pLenti-shnSMase3; lentiviral vector encoding shRNA to nSMase3

<400>  33
aatgtagtct tatgcaatac tcttgtagtc ttgcaacatg gtaacgatga gttagcaaca     60

tgccttacaa ggagagaaaa agcaccgtgc atgccgattg gtggaagtaa ggtggtacga    120

tcgtgcctta ttaggaaggc aacagacggg tctgacatgg attggacgaa ccactgaatt    180

gccgcattgc agagatattg tatttaagtg cctagctcga tacataaacg ggtctctctg    240

gttagaccag atctgagcct gggagctctc tggctaacta gggaacccac tgcttaagcc    300

tcaataaagc ttgccttgag tgcttcaagt agtgtgtgcc cgtctgttgt gtgactctgg    360

taactagaga tccctcagac ccttttagtc agtgtggaaa atctctagca gtggcgcccg    420

aacagggact tgaaagcgaa agggaaacca gaggagctct ctcgacgcag gactcggctt    480

gctgaagcgc gcacggcaag aggcgagggg cggcgactgg tgagtacgcc aaaaattttg    540

actagcggag gctagaagga gagagatggg tgcgagagcg tcagtattaa gcgggggaga    600

attagatcgc gatgggaaaa aattcggtta aggccagggg gaaagaaaaa atataaatta    660

aaacatatag tatgggcaag cagggagcta gaacgattcg cagttaatcc tggcctgtta    720

gaaacatcag aaggctgtag acaaatactg ggacagctac aaccatccct tcagacagga    780

tcagaagaac ttagatcatt atataataca gtagcaaccc tctattgtgt gcatcaaagg    840

atagagataa aagacaccaa ggaagcttta gacaagatag aggaagagca aaacaaaagt    900

aagaccaccg cacagcaagc ggccgctgat cttcagacct ggaggaggag atatgaggga    960

caattggaga agtgaattat ataaatataa agtagtaaaa attgaaccat taggagtagc   1020

acccaccaag gcaaagagaa gagtggtgca gagagaaaaa agagcagtgg gaataggagc   1080

tttgttcctt gggttcttgg gagcagcagg aagcactatg ggcgcagcgt caatgacgct   1140

gacggtacag gccagacaat tattgtctgg tatagtgcag cagcagaaca atttgctgag   1200

ggctattgag gcgcaacagc atctgttgca actcacagtc tggggcatca agcagctcca   1260

ggcaagaatc ctggctgtgg aaagatacct aaaggatcaa cagctcctgg ggatttgggg   1320

ttgctctgga aaactcattt gcaccactgc tgtgccttgg aatgctagtt ggagtaataa   1380

atctctggaa cagatttgga atcacacgac ctggatggag tgggacagag aaattaacaa   1440

ttacacaagc ttaatacact ccttaattga agaatcgcaa aaccagcaag aaaagaatga   1500

acaagaatta ttggaattag ataaatgggc aagtttgtgg aattggttta acataacaaa   1560

ttggctgtgg tatataaaat tattcataat gatagtagga ggcttggtag gtttaagaat   1620

agtttttgct gtactttcta tagtgaatag agttaggcag ggatattcac cattatcgtt   1680

tcagacccac ctcccaaccc cgaggggacc cgacaggccc gaaggaatag aagaagaagg   1740

tggagagaga gacagagaca gatccattcg attagtgaac ggatctcgac ggtatcggat   1800

ctggcctccg cgccgggttt tggcgcctcc cgcgtaccga gctcggatcc actagtccag   1860

tgtggtggaa ttctgcagat atcaacaagt ttgtacaaaa aagcaggcta gcattcctgc   1920

agttctagaa ctagtggatc ccccgggctg caggaattcg aacgctgacg tcatcaaccc   1980

gctccaagga atcgcgggcc cagtgtcact aggcgggaac acccagcgcg cgtgcgccct   2040

ggcaggaaga tggctgtgag ggacagggga gtggcgccct gcaatatttg catgtcgcta   2100

tgtgttctgg gaaatcacca taaacgtgaa atgtctttgg atttgggaat cttataagtt   2160

ctgtatgaga ccacagatct cccctgctga tgtacaccaa gttcaagaga cttggtgtac   2220

atcagcaggt ttttaagctt atcgataccg tcgacctcga gggggggccc ggtaccaatc   2280

gatttaaata gctcgctagc acccagcttt cttgtacaaa gtggttgata tccagcacag   2340

tggcggccgc tcgagtctag agggcccgcg gttcgaaggt aagcctatcc ctaaccctct   2400

cctcggtctc gattctacgc gtaccggtta gtaatgagtt tggaattaat tctgtggaat   2460

gtgtgtcagt tagggtgtgg aaagtcccca ggctccccag gcaggcagaa gtatgcaaag   2520

catgcatctc aattagtcag caaccaggtg tggaaagtcc ccaggctccc cagcaggcag   2580

aagtatgcaa agcatgcatc tcaattagtc agcaaccata gtcccgcccc taactccgcc   2640

catcccgccc ctaactccgc ccagttccgc ccattctccg ccccatggct gactaatttt   2700

ttttatttat gcagaggccg aggccgcctc tgcctctgag ctattccaga agtagtgagg   2760

aggctttttt ggaggcctag gcttttgcaa aaagctcccg ggagcttgta tatccatttt   2820

cggatctgat cagcacgtgt tgacaattaa tcatcggcat agtatatcgg catagtataa   2880

tacgacaagg tgaggaacta aaccatggcc aagcctttgt ctcaagaaga atccaccctc   2940

attgaaagag caacggctac aatcaacagc atccccatct ctgaagacta cagcgtcgcc   3000

agcgcagctc tctctagcga cggccgcatc ttcactggtg tcaatgtata tcattttact   3060

gggggacctt gtgcagaact cgtggtgctg ggcactgctg ctgctgcggc agctggcaac   3120

ctgacttgta tcgtcgcgat cggaaatgag aacaggggca tcttgagccc ctgcggacgg   3180

tgccgacagg tgcttctcga tctgcatcct gggatcaaag ccatagtgaa ggacagtgat   3240

ggacagccga cggcagttgg gattcgtgaa ttgctgccct ctggttatgt gtgggagggc   3300

taagcacaat tcgagctcgg tacctttaag accaatgact tacaaggcag ctgtagatct   3360

tagccacttt ttaaaagaaa aggggggact ggaagggcta attcactccc aacgaagaca   3420

agatctgctt tttgcttgta ctgggtctct ctggttagac cagatctgag cctgggagct   3480

ctctggctaa ctagggaacc cactgcttaa gcctcaataa agcttgcctt gagtgcttca   3540

agtagtgtgt gcccgtctgt tgtgtgactc tggtaactag agatccctca gaccctttta   3600

gtcagtgtgg aaaatctcta gcagtagtag ttcatgtcat cttattattc agtatttata   3660

acttgcaaag aaatgaatat cagagagtga gaggaacttg tttattgcag cttataatgg   3720

ttacaaataa agcaatagca tcacaaattt cacaaataaa gcattttttt cactgcattc   3780

tagttgtggt ttgtccaaac tcatcaatgt atcttatcat gtctggctct agctatcccg   3840

cccctaactc cgcccatccc gcccctaact ccgcccagtt ccgcccattc tccgccccat   3900

ggctgactaa ttttttttat ttatgcagag gccgaggccg cctcggcctc tgagctattc   3960

cagaagtagt gaggaggctt ttttggaggc ctagggacgt acccaattcg ccctatagtg   4020

agtcgtatta cgcgcgctca ctggccgtcg ttttacaacg tcgtgactgg gaaaaccctg   4080

gcgttaccca acttaatcgc cttgcagcac atcccccttt cgccagctgg cgtaatagcg   4140

aagaggcccg caccgatcgc ccttcccaac agttgcgcag cctgaatggc gaatgggacg   4200

cgccctgtag cggcgcatta agcgcggcgg gtgtggtggt tacgcgcagc gtgaccgcta   4260

cacttgccag cgccctagcg cccgctcctt tcgctttctt cccttccttt ctcgccacgt   4320

tcgccggctt tccccgtcaa gctctaaatc gggggctccc tttagggttc cgatttagtg   4380

ctttacggca cctcgacccc aaaaaacttg attagggtga tggttcacgt agtgggccat   4440

cgccctgata gacggttttt cgccctttga cgttggagtc cacgttcttt aatagtggac   4500

tcttgttcca aactggaaca acactcaacc ctatctcggt ctattctttt gatttataag   4560

ggattttgcc gatttcggcc tattggttaa aaaatgagct gatttaacaa aaatttaacg   4620

cgaattttaa caaaatatta acgcttacaa tttaggtggc acttttcggg gaaatgtgcg   4680

cggaacccct atttgtttat ttttctaaat acattcaaat atgtatccgc tcatgagaca   4740

ataaccctga taaatgcttc aataatattg aaaaaggaag agtatgagta ttcaacattt   4800

ccgtgtcgcc cttattccct tttttgcggc attttgcctt cctgtttttg ctcacccaga   4860

aacgctggtg aaagtaaaag atgctgaaga tcagttgggt gcacgagtgg gttacatcga   4920

actggatctc aacagcggta agatccttga gagttttcgc cccgaagaac gttttccaat   4980

gatgagcact tttaaagttc tgctatgtgg cgcggtatta tcccgtattg acgccgggca   5040

agagcaactc ggtcgccgca tacactattc tcagaatgac ttggttgagt actcaccagt   5100

cacagaaaag catcttacgg atggcatgac agtaagagaa ttatgcagtg ctgccataac   5160

catgagtgat aacactgcgg ccaacttact tctgacaacg atcggaggac cgaaggagct   5220

aaccgctttt ttgcacaaca tgggggatca tgtaactcgc cttgatcgtt gggaaccgga   5280

gctgaatgaa gccataccaa acgacgagcg tgacaccacg atgcctgtag caatggcaac   5340

aacgttgcgc aaactattaa ctggcgaact acttactcta gcttcccggc aacaattaat   5400

agactggatg gaggcggata aagttgcagg accacttctg cgctcggccc ttccggctgg   5460

ctggtttatt gctgataaat ctggagccgg tgagcgtggg tctcgcggta tcattgcagc   5520

actggggcca gatggtaagc cctcccgtat cgtagttatc tacacgacgg ggagtcaggc   5580

aactatggat gaacgaaata gacagatcgc tgagataggt gcctcactga ttaagcattg   5640

gtaactgtca gaccaagttt actcatatat actttagatt gatttaaaac ttcattttta   5700

atttaaaagg atctaggtga agatcctttt tgataatctc atgaccaaaa tcccttaacg   5760

tgagttttcg ttccactgag cgtcagaccc cgtagaaaag atcaaaggat cttcttgaga   5820

tccttttttt ctgcgcgtaa tctgctgctt gcaaacaaaa aaaccaccgc taccagcggt   5880

ggtttgtttg ccggatcaag agctaccaac tctttttccg aaggtaactg gcttcagcag   5940

agcgcagata ccaaatactg ttcttctagt gtagccgtag ttaggccacc acttcaagaa   6000

ctctgtagca ccgcctacat acctcgctct gctaatcctg ttaccagtgg ctgctgccag   6060

tggcgataag tcgtgtctta ccgggttgga ctcaagacga tagttaccgg ataaggcgca   6120

gcggtcgggc tgaacggggg gttcgtgcac acagcccagc ttggagcgaa cgacctacac   6180

cgaactgaga tacctacagc gtgagctatg agaaagcgcc acgcttcccg aagggagaaa   6240

ggcggacagg tatccggtaa gcggcagggt cggaacagga gagcgcacga gggagcttcc   6300

agggggaaac gcctggtatc tttatagtcc tgtcgggttt cgccacctct gacttgagcg   6360

tcgatttttg tgatgctcgt caggggggcg gagcctatgg aaaaacgcca gcaacgcggc   6420

ctttttacgg ttcctggcct tttgctggcc ttttgctcac atgttctttc ctgcgttatc   6480

ccctgattct gtggataacc gtattaccgc ctttgagtga gctgataccg ctcgccgcag   6540

ccgaacgacc gagcgcagcg agtcagtgag cgaggaagcg gaagagcgcc caatacgcaa   6600

accgcctctc cccgcgcgtt ggccgattca ttaatgcagc tggcacgaca ggtttcccga   6660

ctggaaagcg ggcagtgagc gcaacgcaat taatgtgagt tagctcactc attaggcacc   6720

ccaggcttta cactttatgc ttccggctcg tatgttgtgt ggaattgtga gcggataaca   6780

atttcacaca ggaaacagct atgaccatga ttacgccaag cgcgcaatta accctcacta   6840

aagggaacaa aagctggagc tgcaagctt                                     6869





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