                         SEQUENCE LISTING

<110>  MedImmune Inc
       Wu, Herren
       Allan, Christian
       Gao, Changshou
       An, Ling-Ling
       Kiener, Peter
       Mao, Su-Yau
       Coyle, Anthony
 
<120>  High Affinity Antibodies Against HMGB1 and Method of Use Thereof

<130>  HB602PCT

<150>  60/739,938
<151>  2005-11-28

<150>  60/765,746
<151>  2006-02-07

<150>  60/799,639
<151>  2006-05-12

<150>  60/822,044
<151>  2006-08-10

<150>  60/822,044
<151>  2006-08-10

<160>  110   

<170>  PatentIn version 3.3

<210>  1
<211>  215
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Gly Lys Gly Asp Pro Lys Lys Pro Arg Gly Lys Met Ser Ser Tyr 
1               5                   10                  15      


Ala Phe Phe Val Gln Thr Cys Arg Glu Glu His Lys Lys Lys His Pro 
            20                  25                  30          


Asp Ala Ser Val Asn Phe Ser Glu Phe Ser Lys Lys Cys Ser Glu Arg 
        35                  40                  45              


Trp Lys Thr Met Ser Ala Lys Glu Lys Gly Lys Phe Glu Asp Met Ala 
    50                  55                  60                  


Lys Ala Asp Lys Ala Arg Tyr Glu Arg Glu Met Lys Thr Tyr Ile Pro 
65                  70                  75                  80  


Pro Lys Gly Glu Thr Lys Lys Lys Phe Lys Asp Pro Asn Ala Pro Lys 
                85                  90                  95      


Arg Pro Pro Ser Ala Phe Phe Leu Phe Cys Ser Glu Tyr Arg Pro Lys 
            100                 105                 110         


Ile Lys Gly Glu His Pro Gly Leu Ser Ile Gly Asp Val Ala Lys Lys 
        115                 120                 125             


Leu Gly Glu Met Trp Asn Asn Thr Ala Ala Asp Asp Lys Gln Pro Tyr 
    130                 135                 140                 


Glu Lys Lys Ala Ala Lys Leu Lys Glu Lys Tyr Glu Lys Asp Ile Ala 
145                 150                 155                 160 


Ala Tyr Arg Ala Lys Gly Lys Pro Asp Ala Ala Lys Lys Gly Val Val 
                165                 170                 175     


Lys Ala Glu Lys Ser Lys Lys Lys Lys Glu Glu Glu Glu Asp Glu Glu 
            180                 185                 190         


Asp Glu Glu Asp Glu Glu Glu Glu Glu Asp Glu Glu Asp Glu Asp Glu 
        195                 200                 205             


Glu Glu Asp Asp Asp Asp Glu 
    210                 215 


<210>  2
<211>  215
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Gly Lys Gly Asp Pro Lys Lys Pro Thr Gly Lys Met Ser Ser Tyr 
1               5                   10                  15      


Ala Phe Phe Val Gln Thr Cys Arg Glu Glu His Lys Lys Lys His Pro 
            20                  25                  30          


Asp Ala Ser Val Asn Phe Ser Glu Phe Ser Lys Lys Cys Ser Glu Arg 
        35                  40                  45              


Trp Lys Thr Met Ser Ala Lys Glu Lys Gly Lys Phe Glu Asp Met Ala 
    50                  55                  60                  


Lys Ala Asp Lys Ala Arg Tyr Glu Arg Glu Met Lys Thr Tyr Ile Pro 
65                  70                  75                  80  


Pro Lys Gly Glu Thr Lys Lys Lys Phe Lys Asp Pro Asn Ala Pro Lys 
                85                  90                  95      


Arg Leu Pro Ser Ala Phe Phe Leu Phe Cys Ser Glu Tyr Arg Pro Lys 
            100                 105                 110         


Ile Lys Gly Glu His Pro Gly Leu Ser Ile Gly Asp Val Ala Lys Lys 
        115                 120                 125             


Leu Gly Glu Met Trp Asn Asn Thr Ala Ala Asp Asp Lys Gln Pro Tyr 
    130                 135                 140                 


Glu Lys Lys Ala Ala Lys Leu Lys Glu Lys Tyr Glu Lys Asp Ile Ala 
145                 150                 155                 160 


Ala Tyr Arg Ala Lys Gly Lys Pro Asp Ala Ala Lys Lys Gly Val Val 
                165                 170                 175     


Lys Ala Glu Lys Ser Lys Lys Lys Lys Glu Glu Glu Glu Asp Glu Glu 
            180                 185                 190         


Asp Glu Glu Asp Glu Glu Glu Glu Glu Asp Glu Glu Asp Glu Glu Asp 
        195                 200                 205             


Glu Glu Asp Asp Asp Asp Glu 
    210                 215 


<210>  3
<211>  77
<212>  PRT
<213>  Homo sapiens

<400>  3

Pro Thr Gly Lys Met Ser Ser Tyr Ala Phe Phe Val Gln Thr Cys Arg 
1               5                   10                  15      


Glu Glu His Lys Lys Lys His Pro Asp Ala Ser Val Asn Phe Ser Glu 
            20                  25                  30          


Phe Ser Lys Lys Cys Ser Glu Arg Trp Lys Thr Met Ser Ala Lys Glu 
        35                  40                  45              


Lys Gly Lys Phe Glu Asp Met Ala Lys Ala Asp Lys Ala Arg Tyr Glu 
    50                  55                  60                  


Arg Glu Met Lys Thr Tyr Ile Pro Pro Lys Gly Glu Thr 
65                  70                  75          


<210>  4
<211>  74
<212>  PRT
<213>  Homo sapiens

<400>  4

Phe Lys Asp Pro Asn Ala Pro Lys Arg Leu Pro Ser Ala Phe Phe Leu 
1               5                   10                  15      


Phe Cys Ser Glu Tyr Arg Pro Lys Ile Lys Gly Glu His Pro Gly Leu 
            20                  25                  30          


Ser Ile Gly Asp Val Ala Lys Lys Leu Gly Glu Met Trp Asn Asn Thr 
        35                  40                  45              


Ala Ala Asp Asp Lys Gln Pro Tyr Glu Lys Lys Ala Ala Lys Leu Lys 
    50                  55                  60                  


Glu Lys Tyr Glu Lys Asp Ile Ala Ala Tyr 
65                  70                  


<210>  5
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  5

Ala Gln Asp Ile Gln Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser 
1               5                   10                  15      


Leu Gly Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu 
            20                  25                  30          


Tyr Ser Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro 
        35                  40                  45              


Gly Gln Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser 
    50                  55                  60                  


Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
65                  70                  75                  80  


Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys 
                85                  90                  95      


Gln Gln Tyr Tyr Ser Thr Pro Arg Thr Phe Gly Gln Gly Thr Lys Val 
            100                 105                 110         


Glu Ile Lys 
        115 


<210>  6
<211>  345
<212>  DNA
<213>  Homo sapiens

<400>  6
gcacaagaca tccagatgac ccagtctcca gactccctgg ctgtgtctct gggcgagagg     60

gccaccatca actgcaagtc cagccagagt gttttataca gctccaacaa taagaactac    120

ttagcttggt accagcagaa accaggacag cctcctaagc tgctcattta ctgggcatct    180

acccgggaat ccggggtccc tgaccgattc agtggcagcg ggtctgggac agatttcact    240

ctcaccatca gcagcctgca ggctgaagat gtggcagttt attactgtca gcaatattat    300

agtactcctc ggacgttcgg ccaagggacc aaggtggaaa tcaaa                    345


<210>  7
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  7

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          


Met Met Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Arg Ile Ser Pro Ser Gly Gly Gln Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Glu Gly Gly Ser Tyr Gly Ala Phe Asp Ile Trp Gly Gln 
            100                 105                 110         


Gly Thr Met Val Thr Val Ser Ser 
        115                 120 


<210>  8
<211>  360
<212>  DNA
<213>  Homo sapiens

<400>  8
gaagttcaat tgttagagtc tggtggcggt cttgttcagc ctggtggttc tttacgtctt     60

tcttgcgctg cttccggatt cactttctct ggttacatga tggtttgggt tcgccaagct    120

cctggtaaag gtttggagtg ggtttctcgt atctctcctt ctggtggcca gactggttat    180

gctgactccg ttaaaggtcg cttcactatc tctagagaca actctaagaa tactctctac    240

ttgcagatga acagcttaag ggctgaggac acggccgtgt attactgtgc gagagaagag    300

ggtgggagct acggggcttt tgatatctgg ggccaaggga caatggtcac cgtctcaagc    360


<210>  9
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  9

Ala Gln Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
1               5                   10                  15      


Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser 
            20                  25                  30          


Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr 
                85                  90                  95      


Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 


<210>  10
<211>  327
<212>  DNA
<213>  Homo sapiens

<400>  10
gcacaagaca tccagatgac ccagtctcca tcctccctgt ctgcatctgt aggagacaga     60

gtcaccatca cttgccgggc aagtcagagc attagcagct atttaaattg gtatcagcag    120

aaaccaggga aagcccctaa actcctgatc tatgctgcat ccagtttgca aagtggggtc    180

ccctcaaggt tcagtggcag tggatctggg acagatttca ctctcaccat cagcagtctg    240

caacctgaag attttgcaac ttactactgt caacagagtt acagtacccc tcggacgttc    300

ggccaaggga ccaaggtgga aatcaaa                                        327


<210>  11
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  11

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Trp Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Arg Ile Ser Pro Ser Gly Gly Tyr Thr Met Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Glu Val Gly Ala Thr Ser Gly Gly Thr Ala Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210>  12
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  12
gaagttcaat tgttagagtc tggtggcggt cttgttcagc ctggtggttc tttacgtctt     60

tcttgcgctg cttccggatt cactttctct tggtacgata tgtcttgggt tcgccaagct    120

cctggtaaag gtttggagtg ggtttctcgt atctctcctt ctggtggcta tactatgtat    180

gctgactccg ttaaaggtcg cttcactatc tctagagaca actctaagaa tactctctac    240

ttgcagatga acagcttaag ggctgaggac acggccgtgt attactgtgc gagactcgag    300

gtgggagcta cttcgggggg tacggctttt gatatctggg gccaagggac aatggtcacc    360

gtctcaagc                                                            369


<210>  13
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  13

Ala Gln Asp Ile Gln Met Thr Gln Ser Pro Asp Thr Leu Ser Leu Ser 
1               5                   10                  15      


Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Asn 
            20                  25                  30          


Ser Arg Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg 
        35                  40                  45              


Leu Leu Ile Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Asp Arg 
    50                  55                  60                  


Phe Ser Gly Ser Val Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser 
65                  70                  75                  80  


Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser 
                85                  90                  95      


Tyr Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 


<210>  14
<211>  327
<212>  DNA
<213>  Homo sapiens

<400>  14
gcacaagaca tccagatgac ccagtctcca gacaccctgt ctttgtctcc aggggaaaga     60

gccaccctct cctgcagggc cagtcagagt gttaacagca ggaacttagc ctggtaccag    120

cagaaacctg gccaggctcc caggctcctc atctatggtg catccaccag ggccactggc    180

atcccagaca ggttcagtgg cagtgtatct gggacagaat tcactctcac catcagcagc    240

ctgcagcctg atgattttgc aacttattac tgccagcaat ataacagtta tttcactttt    300

ggccagggga ccaagctgga gatcaaa                                        327


<210>  15
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  15

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Trp Tyr 
            20                  25                  30          


Ser Met Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Pro Ser Gly Gly Phe Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Tyr Asn Ser Gly Trp Tyr Tyr Asp His Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  16
<211>  360
<212>  DNA
<213>  Homo sapiens

<400>  16
gaagttcaat tgttagagtc tggtggcggt cttgttcagc ctggtggttc tttacgtctt     60

tcttgcgctg cttccggatt cactttctct tggtactcta tgctttgggt tcgccaagct    120

cctggtaaag gtttggagtg ggtttcttat atctctcctt ctggtggctt tactaattat    180

gctgactccg ttaaaggtcg cttcactatc tctagagaca actctaagaa tactctctac    240

ttgcagatga acagcttaag ggctgaggac acggccgtgt attactgtgc gaggtgggac    300

tacaacagtg gctggtacta tgaccactgg ggccagggca ccctggtcac cgtctcaagc    360


<210>  17
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  17

Ala Gln Asp Ile Gln Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser 
1               5                   10                  15      


Pro Gly Glu Gly Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser 
            20                  25                  30          


Ser Thr Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg 
        35                  40                  45              


Leu Leu Ile Tyr Glu Ala Ser Lys Arg Ala Thr Gly Thr Pro Ala Arg 
    50                  55                  60                  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Ser Ser 
65                  70                  75                  80  


Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Arg His Asn 
                85                  90                  95      


Trp Pro Pro Gln Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Val Lys 
            100                 105                 110         


<210>  18
<211>  336
<212>  DNA
<213>  Homo sapiens

<400>  18
gcacaagaca tccagatgac ccagtctcca ggcaccctgt ctttgtctcc aggggaagga     60

gccaccctct cctgcagggc cagtcagagt gttagcagca cctacttagc ctggtaccag    120

cagaaacctg gccaggctcc caggctcctc atctatgaag cgtccaagag ggccacaggc    180

accccagcca ggttcagtgg cagtgggtct gggacagact tcactctcag catcagcagc    240

ctagagcctg aagattttgc agtttattac tgtcagcacc gtcacaactg gcctccacag    300

tggacgttcg gccaagggac caaggtggag gtcaaa                              336


<210>  19
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  19

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Trp Tyr 
            20                  25                  30          


Asp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Pro Ser Gly Gly Tyr Thr Lys Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Thr Glu Phe Tyr Asp Tyr Leu Asp Val Trp Gly Lys Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  20
<211>  351
<212>  DNA
<213>  Homo sapiens

<400>  20
gaagttcaat tgttagagtc tggtggcggt cttgttcagc ctggtggttc tttacgtctt     60

tcttgcgctg cttccggatt cactttctct tggtacgata tgacttgggt tcgccaagct    120

cctggtaaag gtttggagtg ggtttcttcc atctctcctt ctggtggcta tactaagtat    180

gctgactccg ttaaaggtcg cttcactatc tctagagaca actctaagaa tactctctac    240

ttgcagatga acagcttaag ggctgaggac acagccgtgt attactgtac cacagaattc    300

tacgattacc tggacgtctg gggcaaaggg accacggtca ccgtctcaag c             351


<210>  21
<211>  209
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Gly Lys Gly Asp Pro Asn Lys Pro Arg Gly Lys Met Ser Ser Tyr 
1               5                   10                  15      


Ala Phe Phe Val Gln Thr Cys Arg Glu Glu His Lys Lys Lys His Pro 
            20                  25                  30          


Asp Ser Ser Val Asn Phe Ala Glu Phe Ser Lys Lys Cys Ser Glu Arg 
        35                  40                  45              


Trp Lys Thr Met Ser Ala Lys Glu Lys Ser Lys Phe Glu Asp Met Ala 
    50                  55                  60                  


Lys Ser Asp Lys Ala Arg Tyr Asp Arg Glu Met Lys Asn Tyr Val Pro 
65                  70                  75                  80  


Pro Lys Gly Asp Lys Lys Gly Lys Lys Lys Asp Pro Asn Ala Pro Lys 
                85                  90                  95      


Arg Pro Pro Ser Ala Phe Phe Leu Phe Cys Ser Glu His Arg Pro Lys 
            100                 105                 110         


Ile Lys Ser Glu His Pro Gly Leu Ser Ile Gly Asp Thr Ala Lys Lys 
        115                 120                 125             


Leu Gly Glu Met Trp Ser Glu Gln Ser Ala Lys Asp Lys Gln Pro Tyr 
    130                 135                 140                 


Glu Gln Lys Ala Ala Lys Leu Lys Glu Lys Tyr Glu Lys Asp Ile Ala 
145                 150                 155                 160 


Ala Tyr Arg Ala Lys Gly Lys Ser Glu Ala Gly Lys Lys Gly Pro Gly 
                165                 170                 175     


Arg Pro Thr Gly Ser Lys Lys Lys Asn Glu Pro Glu Asp Glu Glu Glu 
            180                 185                 190         


Glu Glu Glu Glu Glu Asp Glu Asp Glu Glu Glu Glu Asp Glu Asp Glu 
        195                 200                 205             


Glu 
    


<210>  22
<211>  77
<212>  PRT
<213>  Homo sapiens

<400>  22

Pro Arg Gly Lys Met Ser Ser Tyr Ala Phe Phe Val Gln Thr Cys Arg 
1               5                   10                  15      


Glu Glu His Lys Lys Lys His Pro Asp Ser Ser Val Asn Phe Ala Glu 
            20                  25                  30          


Phe Ser Lys Lys Cys Ser Glu Arg Trp Lys Thr Met Ser Ala Lys Glu 
        35                  40                  45              


Lys Ser Lys Phe Glu Asp Met Ala Lys Ser Asp Lys Ala Arg Tyr Asp 
    50                  55                  60                  


Arg Glu Met Lys Asn Tyr Val Pro Pro Lys Gly Asp Lys 
65                  70                  75          


<210>  23
<211>  75
<212>  PRT
<213>  Homo sapiens

<400>  23

Lys Lys Lys Asp Pro Asn Ala Pro Lys Arg Pro Pro Ser Ala Phe Phe 
1               5                   10                  15      


Leu Phe Cys Ser Glu His Arg Pro Lys Ile Lys Ser Glu His Pro Gly 
            20                  25                  30          


Leu Ser Ile Gly Asp Thr Ala Lys Lys Leu Gly Glu Met Trp Ser Glu 
        35                  40                  45              


Gln Ser Ala Lys Asp Lys Gln Pro Tyr Glu Gln Lys Ala Ala Lys Leu 
    50                  55                  60                  


Lys Glu Lys Tyr Glu Lys Asp Ile Ala Ala Tyr 
65                  70                  75  


<210>  24
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  24

Ala Gln Asp Ile Gln Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser 
1               5                   10                  15      


Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Arg 
            20                  25                  30          


Ser Asn Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg 
        35                  40                  45              


Leu Leu Ile Tyr Gly Ala Ser Arg Arg Ala Ser Gly Ile Pro Asp Arg 
    50                  55                  60                  


Phe Ser Gly Ser Gly Phe Gly Ala Asp Phe Thr Leu Ser Ile Ser Arg 
65                  70                  75                  80  


Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser 
                85                  90                  95      


Ser Pro Asn Thr Phe Gly Gln Gly Ser Arg Val Glu Ile Lys 
            100                 105                 110 


<210>  25
<211>  330
<212>  DNA
<213>  Homo sapiens

<400>  25
gcacaagaca tccagatgac ccagtctcca ggcaccctgt ctttgtctcc aggggaaaga     60

gccaccctct cctgcagggc cagtcagagt gttaggagca acttcttggc ctggtaccag    120

cagaaacctg gccaggctcc caggctcctc atatatggtg catccaggag ggccagtggc    180

atcccagaca ggttcagtgg cagtgggttt ggggcagact tcactctcag catcagcaga    240

ctggagcctg aagatttcgc agtgtattac tgtcagcagt atggtagctc acccaacact    300

tttggccagg ggtccagggt ggagatcaaa                                     330


<210>  26
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  26

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          


Gln Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Pro Ser Gly Gly His Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Gly Arg Gln Gly Lys Ile Ser Thr Val Asp His Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  27
<211>  363
<212>  DNA
<213>  Homo sapiens

<400>  27
gaagttcaat tgttagagtc tggtggcggt cttgttcagc ctggtggttc tttacgtctt     60

tcttgcgctg cttccggatt cactttctct cgttaccaga tgaattgggt tcgccaagct    120

cctggtaaag gtttggagtg ggtttcttct atctctcctt ctggtggcca tactcattat    180

gctgactccg ttaaaggtcg cttcactatc tctagagaca actctaagaa tactctctac    240

ttgcagatga acagcttaag ggctgaggac acggccgtgt attactgtgc gaaagatgga    300

cgacagggta aaataagtac ggttgaccac tggggccagg gaaccctggt caccgtctca    360

agc                                                                  363


<210>  28
<211>  79
<212>  PRT
<213>  Homo sapiens

<400>  28

Asp Pro Asn Ala Pro Lys Arg Leu Pro Ser Ala Phe Phe Leu Phe Cys 
1               5                   10                  15      


Ser Glu Tyr Arg Pro Lys Ile Lys Gly Glu His Pro Gly Leu Ser Ile 
            20                  25                  30          


Gly Asp Val Ala Lys Lys Leu Gly Glu Met Trp Asn Asn Thr Ala Ala 
        35                  40                  45              


Asp Asp Lys Gln Pro Tyr Glu Lys Lys Ala Ala Lys Leu Lys Glu Lys 
    50                  55                  60                  


Tyr Glu Lys Asp Ile Ala Ala Tyr Arg Ala Lys Gly Lys Pro Asp 
65                  70                  75                  


<210>  29
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  29

Lys Leu Lys Glu Lys Tyr Glu Lys Asp Ile Ala Ala Tyr Arg Ala Lys 
1               5                   10                  15      


Gly Lys Pro Asp Ala Ala Lys Lys Gly Val Val Lys Ala Glu Lys Ser 
            20                  25                  30          


Lys Lys 
        


<210>  30
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  30

Ala Gln Ser Glu Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Gly 
1               5                   10                  15      


Gln Arg Val Thr Ile Ser Cys Ser Gly Ser Thr Ser Asn Ile Gly Asn 
            20                  25                  30          


Asn Ala Val Ile Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Tyr Asp Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Gly Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Trp Asp Asp Asn 
                85                  90                  95      


Leu Asn Gly Pro Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  31
<211>  333
<212>  DNA
<213>  Homo sapiens

<400>  31
gcacagagcg aattgactca gccaccctcg gtgtctgaag cccccgggca gagggtcacc     60

atctcctgtt ctggaagcac ctccaacatc ggaaataatg ctgtaatctg gtaccagcag    120

ctcccaggaa aggctcccaa actcctcatc tattatgatg atctgctgcc ctcaggggtc    180

tctgaccgat tctctggctc caagtctggc acctcaggct ccctggccat cagtgggctc    240

cagtctgagg atgaggctga ctattactgt gcatcatggg atgacaacct gaatggtccg    300

ctgttcggcg gagggaccaa gttgaccgtc cta                                 333


<210>  32
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  32

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Trp Tyr 
            20                  25                  30          


Lys Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Pro Ser Gly Gly Ser Thr Ala Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Met Gly Leu Phe Asn Thr Gly Asn Ser Tyr Val Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  33
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  33
gaagttcaat tgttagagtc tggtggcggt cttgttcagc ctggtggttc tttacgtctt     60

tcttgcgctg cttccggatt cactttctct tggtacaaga tgcagtgggt tcgccaagct    120

cctggtaaag gtttggagtg ggtttctggt atctctcctt ctggtggctc tactgcttat    180

gctgactccg ttaaaggtcg cttcactatc tctagagaca actctaagaa tactctctac    240

ttgcagatga acagcttaag ggctgaggac acggccgtgt attactgtgc gaaaatgggg    300

ctttttaata ctgggaattc ctacgttgac tactggggac agggaaccct ggtcaccgtc    360

tcaagc                                                               366


<210>  34
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  34

Ala Gln Asp Ile Gln Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser 
1               5                   10                  15      


Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Arg 
            20                  25                  30          


Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg 
        35                  40                  45              


Leu Leu Ile Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Asp Arg 
    50                  55                  60                  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg 
65                  70                  75                  80  


Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Thr 
                85                  90                  95      


Ser Arg Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110 


<210>  35
<211>  330
<212>  DNA
<213>  Homo sapiens

<400>  35
gcacaagaca tccagatgac ccagtctcca ggcaccctgt ctttgtctcc aggggaaaga     60

gccaccctct cctgcagggc cagtcagagt gttaggagca gctacttagc ctggtaccag    120

cagaaacctg gccaggctcc caggctcctc atctatggtg catccaccag ggccactggc    180

atcccagaca ggttcagtgg cagtgggtct gggacagact tcactctcac catcagcaga    240

ctggagcctg aagattttgc agtgtattac tgtcagcagt atggtacctc acggtggacg    300

ttcggccaag ggaccaaggt ggaaatcaaa                                     330


<210>  36
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  36

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Asp Met Phe Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Arg Ile Ser Pro Ser Gly Gly Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Arg Tyr Phe Asp Ser Arg Gly Tyr Ala Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120         


<210>  37
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  37
gaagttcaat tgttagagtc tggtggcggt cttgttcagc ctggtggttc tttacgtctt     60

tcttgcgctg cttccggatt cactttctct tcttacgata tgttttgggt tcgccaagct    120

cctggtaaag gtttggagtg ggtttctcgt atctctcctt ctggtggcta tacttattat    180

gctgactccg ttaaaggtcg cttcactatc tctagagaca actctaagaa tactctctac    240

ttgcagatga acagcttaag ggctgaggac acggccgtgt attactgtgc gaggctacga    300

tattttgact caaggggcta tgcttttgat atctggggcc aagggacaat ggtcaccgtc    360

tcaagc                                                               366


<210>  38
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  38

Ala Gln Asp Ile Gln Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser 
1               5                   10                  15      


Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Ser Leu Thr 
            20                  25                  30          


Ser Thr Tyr Val Ala Trp Tyr Gln His Lys Pro Gly Gln Ala Pro Arg 
        35                  40                  45              


Leu Leu Ile His Gly Gly Ser Thr Arg Ala Thr Gly Ile Pro Val Arg 
    50                  55                  60                  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ala Thr 
65                  70                  75                  80  


Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser 
                85                  90                  95      


Ser Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110 


<210>  39
<211>  330
<212>  DNA
<213>  Homo sapiens

<400>  39
gcacaagaca tccagatgac ccagtctcca ggcaccctgt ctttgtctcc aggggaaaga     60

gccaccctct cctgcagggc cagtgagagt cttaccagca cctacgtagc ctggtaccag    120

cacaaacctg gccaggctcc caggctcctc atccatgggg gatccaccag ggccactggc    180

atcccagtca ggttcagtgg cagtgggtct gggacagact tcactcttac catcgccaca    240

ctggagccgg aagattttgc agtgtattac tgtcagcagt atggtagttc accgtacact    300

tttggccagg ggaccaagct ggagatcaaa                                     330


<210>  40
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  40

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Tyr Tyr 
            20                  25                  30          


Met Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Pro Ser Gly Gly Tyr Thr Ile Tyr Ala Asp Ser Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Leu Ser Thr Gly Ser Phe Trp Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  41
<211>  357
<212>  DNA
<213>  Homo sapiens

<400>  41
gaagttcaat tgttagagtc tggtggcggt cttgttcagc ctggtggttc tttacgtctt     60

tcttgcgctg cttccggatt cactttctct tattacatga tgacttgggt tcgccaagct    120

cctggtaaag gtttggagtg ggtttcttct atctctcctt ctggtggcta tactatttat    180

gctgactccg ctaaaggtcg cttcactatc tctagagaca actctaagaa tactctctac    240

ttgcagatga acagcttaag ggctgaggac acggccgtgt attactgtgc gagagccttg    300

tctactggga gcttctggga ctactggggc cagggaaccc tggtcaccgt ctcaagc       357


<210>  42
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  42

Ala Gln Asp Ile Gln Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser 
1               5                   10                  15      


Pro Gly Glu Ser Gly Thr Leu Ser Cys Arg Ala Ser Glu Ser Val Ser 
            20                  25                  30          


Ser Arg His Phe Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg 
        35                  40                  45              


Leu Leu Ile Tyr Gly Ala Ser Ser Arg Pro Thr Gly Ile Pro Asp Arg 
    50                  55                  60                  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Leu Ser Arg 
65                  70                  75                  80  


Leu Glu Pro Glu Asp Phe Ala Val Tyr Phe Cys Gln Tyr Tyr Gly Ser 
                85                  90                  95      


Ser Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Met Lys 
            100                 105                 110 


<210>  43
<211>  330
<212>  DNA
<213>  Homo sapiens

<400>  43
gcacaagaca tccagatgac ccagtctcca ggcaccctgt ctttgtctcc aggggagagc     60

ggcaccctct cctgtagggc cagtgagagt gttagtagca gacacttcgc ctggtaccag    120

cagaaacctg gccaggctcc caggctcctc atttatggtg catccagcag gcccactggc    180

atcccagaca ggttcagtgg cagtgggtct gggacagact tcactctcac cctcagcaga    240

ctggagcctg aggattttgc agtgtatttc tgtcagtact atggtagctc accgtacact    300

ttcggcggag ggaccaaggt ggagatgaaa                                     330


<210>  44
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  44

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Trp Tyr 
            20                  25                  30          


Lys Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Pro Ser Gly Gly Phe Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Leu Asp Ile Arg His Ala Phe Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser 
        115                 


<210>  45
<211>  357
<212>  DNA
<213>  Homo sapiens

<400>  45
gaagttcaat tgttagagtc tggtggcggt cttgttcagc ctggtggttc tttacgtctt     60

tcttgcgctg cttccggatt cactttctct tggtacaaga tgacttgggt tcgccaagct    120

cctggtaaag gtttggagtg ggtttcttct atctctcctt ctggtggctt tacttcttat    180

gctgactccg ttaaaggtcg cttcactatc tctagagaca actctaagaa tactctctac    240

ttgcagatga acagcttaag ggctgaggac acggccgtgt attactgtgc gagagacctc    300

gatatccggc atgcttttga tatctggggc caagggacaa tggtcaccgt ctcaagc       357


<210>  46
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  46

Ala Gln Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser 
1               5                   10                  15      


Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser 
            20                  25                  30          


Ile Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Phe Gly Ala Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Arg Ser Gly Ala Asp Phe Thr Leu Thr Ile Asp Ser Val 
65                  70                  75                  80  


Gln Pro Glu Asp Phe Ala Ser Tyr Tyr Cys Gln Gln Ala Asp Ser Phe 
                85                  90                  95      


Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 


<210>  47
<211>  327
<212>  DNA
<213>  Homo sapiens

<400>  47
gcacaagaca tccagatgac ccagtctccc tcttccgtgt ctgcatctgt gggagacaga     60

gtcaccatca cttgtcgggc gagtcaggat gttagcatct ggttagcctg gtatcagcag    120

aaaccgggga aagcccctaa gctcctgatc tttggtgcgt cccgtttgca gagtggggtc    180

ccatcgaggt tcagcggcag tcgatctggg gcagatttca ctctcaccat cgacagcgtg    240

cagcctgaag attttgcatc ttactattgt cagcaggctg acagtttccc tctcactttc    300

ggcggaggga ccaaggtgga aatcaaa                                        327


<210>  48
<211>  126
<212>  PRT
<213>  Homo sapiens

<400>  48

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Trp Tyr 
            20                  25                  30          


Asp Met Phe Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Trp Ile Ser Pro Ser Gly Gly Tyr Thr Lys Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Leu Asp Tyr Tyr Asp Ser Ser Gly Tyr Leu Asp Ala 
            100                 105                 110         


Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125     


<210>  49
<211>  378
<212>  DNA
<213>  Homo sapiens

<400>  49
gaagttcaat tgttagagtc tggtggcggt cttgttcagc ctggtggttc tttacgtctt     60

tcttgcgctg cttccggatt cactttctct tggtacgata tgttttgggt tcgccaagct    120

cctggtaaag gtttggagtg ggtttcttgg atctctcctt ctggtggcta tacgaagtat    180

gctgactccg ttaaaggtcg cttcactatc tctagagaca actctaagaa tactctctac    240

ttgcagatga acagcttaag ggctgaggac accgccatgt attactgtgc gagatcaggg    300

ttggattact atgatagtag tggttatctc gatgcttttg atatctgggg ccaagggaca    360

atggtcaccg tctcaagc                                                  378


<210>  50
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  50

Ala Gln Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
1               5                   10                  15      


Val Gly Asp Arg Val Ala Ile Thr Cys Arg Ala Ser Gln Ser Ile Asp 
            20                  25                  30          


Thr Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Ala Ala Ser Lys Leu Glu Asp Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gly Thr Asp Phe Thr Leu Thr Ile Arg Ser Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Phe Ala Ser Tyr Phe Cys Gln Gln Ser Tyr Ser Ser 
                85                  90                  95      


Pro Gly Ile Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110 


<210>  51
<211>  330
<212>  DNA
<213>  Homo sapiens

<400>  51
gcacaagaca tccagatgac ccagtctcca tcctccctgt ctgcatctgt gggagacaga     60

gtcgccatca cttgccgcgc aagtcagagc atcgacacct atttaaattg gtatcagcag    120

aaaccaggga aagcccctaa actcctgatc tatgctgcat ccaagttgga agacggggtc    180

ccatcaagat tcagtggcag tggaactggg acagatttca ctctcaccat cagaagtctg    240

caacctgaag attttgcaag ttatttctgt caacagagct actctagtcc agggatcact    300

ttcggccctg ggaccaaggt ggagatcaaa                                     330


<210>  52
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  52

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


Met Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Arg Ile Ser Pro Ser Gly Gly Gly Thr Val Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Asn Trp Asn Tyr Ile Ser Tyr Tyr Tyr Tyr Tyr Leu 
            100                 105                 110         


Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 


<210>  53
<211>  375
<212>  DNA
<213>  Homo sapiens

<400>  53
gaagttcaat tgttagagtc tggtggcggt cttgttcagc ctggtggttc tttacgtctt     60

tcttgcgctg cttccggatt cactttctct cattacatga tgggttgggt tcgccaagct    120

cctggtaaag gtttggagtg ggtttctcgt atctctcctt ctggtggcgg tactgtttat    180

gctgactccg ttaaaggtcg cttcactatc tctagagaca actctaagaa tactctctac    240

ttgcagatga acagcttaag ggctgaggac acggccgtgt attactgtgc gagaggtggt    300

aactggaact acatatccta ctactactac tacctggacg tctggggcaa agggaccacg    360

gtcaccgtct caagc                                                     375


<210>  54
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  54

Ala Gln Asp Ile Gln Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr 
1               5                   10                  15      


Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu 
            20                  25                  30          


His Gly Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Arg Pro Gly 
        35                  40                  45              


Gln Ser Pro Gln Leu Leu Ile Tyr Ser Gly Ser Asn Arg Ala Ser Gly 
    50                  55                  60                  


Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
65                  70                  75                  80  


Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met 
                85                  90                  95      


Gln Ser Leu Gln Ser Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  55
<211>  339
<212>  DNA
<213>  Homo sapiens

<400>  55
gcacaagaca tccagatgac ccagtctcca ctctccctgc ccgtcacccc tggagagccg     60

gcctccatct cctgcagatc tagtcagagc ctcctgcatg gtaatggata caactatttg    120

gattggtact tgcagaggcc agggcagtct ccacagctcc tgatctattc gggttctaat    180

cgggcctccg gggtccctga caggttcagt ggcagtgggt caggcacaga ctttacactg    240

aaaatcagca gagtggaggc tgaggatgtt ggggtttatt actgcatgca atctctacaa    300

agtcggacgt tcggccaagg gaccaaggtg gaaatcaaa                           339


<210>  56
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  56

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Trp Tyr 
            20                  25                  30          


Lys Met Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Val Pro Ser Gly Gly Ile Thr Ile Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Gln Gln Trp Leu Gly Arg Pro Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  57
<211>  363
<212>  DNA
<213>  Homo sapiens

<400>  57
gaagttcaat tgttagagtc tggtggcggt cttgttcagc ctggtggttc tttacgtctt     60

tcttgcgctg cttccggatt cactttctct tggtacaaga tggtttgggt tcgccaagct    120

cctggtaaag gtttggagtg ggtttcttct atcgttcctt ctggtggcat tactatttat    180

gctgactccg ttaaaggtcg cttcactatc tctagagaca actctaagaa tactctctac    240

ttgcagatga acagcttaag ggctgaggac acggccgtat attactgtgc gagagtgcag    300

cagtggctgg gacggcccta ctttgactac tggggccagg gaaccctggt caccgtctca    360

agc                                                                  363


<210>  58
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  58

Ala Gln Asp Ile Gln Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser 
1               5                   10                  15      


Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Thr Gln Ser Val Arg 
            20                  25                  30          


Lys Asn Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg 
        35                  40                  45              


Leu Leu Ile Tyr Asp Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg 
    50                  55                  60                  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg 
65                  70                  75                  80  


Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Asn 
                85                  90                  95      


Ser Pro Ile Ile Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105                 110 


<210>  59
<211>  330
<212>  DNA
<213>  Homo sapiens

<400>  59
gcacaagaca tccagatgac ccagtctcca ggcaccctgt ctttgtctcc aggcgaaaga     60

gccaccctct cctgcagggc cactcagagt gttagaaaga acttcttagc ctggtatcag    120

cagaaacctg gccaggctcc caggctcctc atctacgatg catccagcag ggccactggc    180

atcccagaca ggttcagtgg cagtgggtct gggacagact tcactctcac catcagcaga    240

ctggagcctg aagattttgc agtgtattac tgtcagcagt atggtaactc acctatcatc    300

ttcggccaag ggacacgact ggagattaaa                                     330


<210>  60
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  60

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Trp Tyr 
            20                  25                  30          


Asp Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Trp Ile Val Pro Ser Gly Gly Ile Thr Ala Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asn Tyr Gly Pro Ser Pro Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  61
<211>  357
<212>  DNA
<213>  Homo sapiens

<400>  61
gaagttcaat tgttagagtc tggtggcggt cttgttcagc ctggtggttc tttacgtctt     60

tcttgcgctg cttccggatt cactttctct tggtacgata tgtggtgggt tcgccaagct    120

cctggtaaag gtttggagtg ggtttcttgg atcgttcctt ctggtggcat tactgcttat    180

gctgactccg ttaaaggtcg cttcactatc tctagagaca actctaagaa tactctctac    240

ttgcagatga acagcttaag ggctgaggac acagccacat attactgtgc gagaggtaac    300

tacggcccat cgccgtttga ctactggggc cagggcaccc tggtcaccgt ctcaagc       357


<210>  62
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  62

Ala Gln Ser Ala Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Arg 
1               5                   10                  15      


Gln Arg Val Thr Ile Ser Cys Ser Gly Ser Thr Ser Asn Ile Gly Asn 
            20                  25                  30          


Asn Ala Val Thr Trp Tyr Gln Tyr Phe Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Ser Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Arg Gly 
                85                  90                  95      


Leu Ser Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  63
<211>  330
<212>  DNA
<213>  Homo sapiens

<400>  63
gcacagagcg ctttgactca gccaccctcg gtgtctgcag cccccaggca gagggtcacc     60

atctcctgtt ctggaagcac ttccaacatc ggaaataatg ctgtaacctg gtaccagtat    120

ttcccaggaa aggctcccaa actcctcatc tatagtgata atcagcggcc ctcaggggtc    180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cactgggctc    240

caggctgagg atgaggctga ttattactgc cagtcgtatg acagaggcct gagtgtggtt    300

ttcggcggag ggaccaagct gaccgtccta                                     330


<210>  64
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  64

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Lys Tyr 
            20                  25                  30          


Ile Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Val Pro Ser Gly Gly Leu Thr Glu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Glu Ile Phe Gly Gln Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  65
<211>  351
<212>  DNA
<213>  Homo sapiens

<400>  65
gaagttgaat tgttagagtc tggtggcggt cttgttcagc ctggtggttc tttacgtctt     60

tcttgcgctg cttccggatt cactttctct aagtacatta tgcattgggt tcgccaagct    120

cctggtaaag gtttggagtg ggtttctggt atcgttcctt ctggtggcct tactgagtat    180

gctgactccg ttaaaggtcg cttcactatc tctagagaca actctaagaa tactctctac    240

ttgcagatga acagcttaag ggctgaggac acagccacat attactgtgc gaaagagatt    300

tttggacaat ttgactactg gggccaggga accctggtca ccgtctcaag c             351


<210>  66
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  66

Ala Gln Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
1               5                   10                  15      


Val Gly Asp Arg Val Thr Ile Ile Cys Arg Ala Asn Glu Arg Ile Asn 
            20                  25                  30          


Thr Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Ser Gly Thr Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Ser Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Phe Ala Ser Tyr Tyr Cys Gln Gln Ser Tyr Ser Ser 
                85                  90                  95      


Pro Tyr Thr Phe Gly Gln Gly Thr Asn Leu Glu Ile Arg 
            100                 105                 


<210>  67
<211>  327
<212>  DNA
<213>  Homo sapiens

<400>  67
gcacaagaca tccagatgac ccagtctcca tcctccctgt ctgcatctgt aggagacaga     60

gtcaccatca tttgccgggc aaatgagcgc ataaacacct atttaaactg gtatcagcag    120

aagccaggaa aagcccctaa gttgttgatt tctggtacat ccagtttgga aagtggggtc    180

ccatcaaggt tcagtggcag tggatctgga acagaattca ctctcagtat cagcagtctg    240

caacctgaag attttgcatc ttactactgt caacagagtt acagttcccc gtacactttt    300

ggccagggga ccaacctgga gatcaga                                        327


<210>  68
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  68

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Trp Tyr 
            20                  25                  30          


Glu Thr Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Pro Ser Gly Gly Tyr Thr Gln Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Val Gly Ala Thr Lys Ile Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  69
<211>  360
<212>  DNA
<213>  Homo sapiens

<400>  69
gaagttcaat tgttagagtc tggtggcggt cttgttcagc ctggtggttc tttacgtctt     60

tcttgcgctg cttccggatt cactttctct tggtacgaga cgggttgggt tcgccaagct    120

cctggtaaag gtttggagtg ggtttctggt atctctcctt ctggtggcta tactcagtat    180

gctgactccg ttaaaggtcg cttcactatc tctagagaca actctaagaa tactctctac    240

ttgcagatga acagcttaag ggctgaggac acggccgtgt attactgtgc gagatcgggg    300

gtgggagcta ctaagatttt tgactactgg ggccagggaa ccctggtcac cgtctcaagc    360


<210>  70
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  70

Ala Gln Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
1               5                   10                  15      


Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly 
            20                  25                  30          


Thr Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Thr Ala Pro Lys Val 
        35                  40                  45              


Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Phe Ser Thr Tyr Tyr Cys Gln Gln Ser Tyr Asn Thr 
                85                  90                  95      


Pro Arg Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 


<210>  71
<211>  327
<212>  DNA
<213>  Homo sapiens

<400>  71
gcacaagaca tccagatgac ccagtctcca tcctccctgt ctgcatctgt aggagacaga     60

gtcaccatca cttgccgggc aagtcagagc attggcacct atttaaattg gtatcagcag    120

aaaccaggga cagcccctaa ggtcctgatc tatgctgcat ccagtttgca aagtggggtc    180

ccatcaaggt tcagtggcag tggatctggg acagatttca ctctcaccat cagcagtctg    240

caacctgaag atttttcaac ttactactgt caacagagtt acaatacccc tcgcactttt    300

ggccagggga ccaaactgga gatcaaa                                        327


<210>  72
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  72

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Tyr Tyr 
            20                  25                  30          


Asp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Arg Ile Ser Pro Ser Gly Gly Tyr Thr Trp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Gly Arg Tyr Thr Ser Gly Trp His Glu Tyr Phe Asp Pro Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  73
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  73
gaagttcaat tgttagagtc tggtggcggt cttgttcagc ctggtggttc tttacgtctt     60

tcttgcgctg cttccggatt cactttctct tattacgata tgcattgggt tcgccaagct    120

cctggtaaag gtttggagtg ggtttctcgt atctctcctt ctggtggcta tacttggtat    180

gctgactccg ttaaaggtcg cttcactatc tctagagaca actctaagaa tactctctac    240

ttgcagatga acagcttaag ggctgaggac acagccgtgt attactgtac gagaggaagg    300

tataccagcg gctggcatga gtacttcgac ccctggggcc agggcaccct ggtcaccgtc    360

tcaagc                                                               366


<210>  74
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  74

Lys Ser Ser Gln Ser Val Leu Tyr Ser Ser Asn Asn Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  75
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  75

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  76
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  76

Gln Gln Tyr Tyr Ser Thr Pro Arg Thr 
1               5                   


<210>  77
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  77

Gly Tyr Met Met Val 
1               5   


<210>  78
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  78

Arg Ile Ser Pro Ser Gly Gly Gln Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  79
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  79

Glu Glu Gly Gly Ser Tyr Gly Ala Phe Asp Ile 
1               5                   10      


<210>  80
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  80

Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 
1               5                   10      


<210>  81
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  81

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  82
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  82

Gln Gln Ser Tyr Ser Thr Pro Arg Thr 
1               5                   


<210>  83
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  83

Trp Tyr Asp Met Ser 
1               5   


<210>  84
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  84

Arg Ile Ser Pro Ser Gly Gly Tyr Thr Met Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  85
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  85

Leu Glu Val Gly Ala Thr Ser Gly Gly Thr Ala Phe Asp Ile 
1               5                   10                  


<210>  86
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  86

Arg Ala Ser Gln Ser Val Asn Ser Arg Asn Leu Ala 
1               5                   10          


<210>  87
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  87

Gly Ala Ser Thr Arg Ala Thr 
1               5           


<210>  88
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  88

Gln Gln Tyr Asn Ser Tyr Phe Thr 
1               5               


<210>  89
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  89

Trp Tyr Ser Met Leu 
1               5   


<210>  90
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  90

Tyr Ile Ser Pro Ser Gly Gly Phe Thr Asn Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  91
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  91

Trp Asp Tyr Asn Ser Gly Trp Tyr Tyr Asp His 
1               5                   10      


<210>  92
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  92

Arg Ala Ser Gln Ser Val Ser Ser Thr Tyr Leu Ala 
1               5                   10          


<210>  93
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  93

Glu Ala Ser Lys Arg Ala Thr 
1               5           


<210>  94
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  94

Gln His Arg His Asn Trp Pro Pro Gln Trp Thr 
1               5                   10      


<210>  95
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  95

Trp Tyr Asp Met Thr 
1               5   


<210>  96
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  96

Ser Ile Ser Pro Ser Gly Gly Tyr Thr Lys Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  97
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  97

Glu Phe Tyr Asp Tyr Leu Asp Val 
1               5               


<210>  98
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  98

Arg Ala Ser Gln Ser Val Arg Ser Asn Phe Leu Ala 
1               5                   10          


<210>  99
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  99

Gly Ala Ser Arg Arg Ala Ser 
1               5           


<210>  100
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  100

Gln Gln Tyr Gly Ser Ser Pro Asn Thr 
1               5                   


<210>  101
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  101

Arg Tyr Gln Met Asn 
1               5   


<210>  102
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  102

Ser Ile Ser Pro Ser Gly Gly His Thr His Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  103
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  103

Asp Gly Arg Gln Gly Lys Ile Ser Thr Val Asp His 
1               5                   10          


<210>  104
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  104
gggggacgat cgtcgggggg                                                 20


<210>  105
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  105
gggggagcat gctggggggc                                                 20


<210>  106
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  106
ggtcgttcca ttttactcca c                                               21


<210>  107
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  107
tcgtcgtttt gtcgttttgt cgtt                                            24


<210>  108
<211>  77
<212>  PRT
<213>  Homo sapiens

<400>  108

Pro Arg Gly Lys Met Ser Ser Tyr Ala Phe Phe Val Gln Thr Cys Arg 
1               5                   10                  15      


Glu Glu His Lys Lys Lys His Pro Asp Ala Ser Val Asn Phe Ser Glu 
            20                  25                  30          


Phe Ser Lys Lys Cys Ser Glu Arg Trp Lys Thr Met Ser Ala Lys Glu 
        35                  40                  45              


Lys Gly Lys Phe Glu Asp Met Ala Lys Ala Asp Lys Ala Arg Tyr Glu 
    50                  55                  60                  


Arg Glu Met Lys Thr Tyr Ile Pro Pro Lys Gly Glu Thr 
65                  70                  75          


<210>  109
<211>  69
<212>  PRT
<213>  Homo sapiens

<400>  109

Pro Lys Arg Pro Pro Ser Ala Phe Phe Leu Phe Cys Ser Glu Tyr Arg 
1               5                   10                  15      


Pro Lys Ile Lys Gly Glu His Pro Gly Leu Ser Ile Gly Asp Val Ala 
            20                  25                  30          


Lys Lys Leu Gly Glu Met Trp Asn Asn Thr Ala Ala Asp Asp Lys Gln 
        35                  40                  45              


Pro Tyr Glu Lys Lys Ala Ala Lys Leu Lys Glu Lys Tyr Glu Lys Asp 
    50                  55                  60                  


Ile Ala Ala Tyr Arg 
65                  


<210>  110
<211>  351
<212>  DNA
<213>  Artificial

<220>
<223>  human heavy chain variable region with three silent mutations

<400>  110
gaagttcaat tgttagagtc tggtggcggt cttgttcagc ctggtggttc tttacgtctt     60

tcttgcgctg cttccggatt cactttctct tggtatgata tgacttgggt tcgccaagct    120

cctggtaaag gtttggagtg ggtttcttcc atctctcctt ctggtggcta tactaagtat    180

gctgactccg ttaaaggtcg cttcactatc tctcgagaca actctaagaa tactctctac    240

ttgcaaatga acagcttaag ggctgaggac acagccgtgt attactgtac cacagaattc    300

tacgattacc tggacgtctg gggcaaaggg accacggtca ccgtctcaag c             351


