                         SEQUENCE LISTING

<110>  Generon Corporation
 
<120>  Antibodies against Interleukin-22 Binding Protein and its Uses 
       for the Treatment of Metabolic Disorders

<130>  G002.002NPRUS

<150>  60/752,397
<151>  2005-12-22

<160>  14    

<170>  PatentIn version 3.3

<210>  1
<211>  230
<212>  PRT
<213>  Mus musculus

<400>  1

Met Met Pro Lys His Cys Leu Leu Gly Leu Leu Ile Ile Leu Leu Ser 
1                         5                                10                           15      


Ser Ala Thr Glu Ile Gln Pro Ala Arg Val Ser Leu Thr Pro Gln Lys 
                   20                           25                             30          


Val Arg Phe Gln Ser Arg Asn Phe His Asn Ile Leu His Trp Gln Ala 
             35                              40                            45              


Gly Ser Ser Leu Pro Ser Asn Asn Ser Ile Tyr Phe Val Gln Tyr Lys 
       50                           55                            60                  


Met Tyr Gly Gln Ser Gln Trp Glu Asp Lys Val Asp Cys Trp Gly Thr 
65                             70                              75                              80  


Thr Ala Leu Phe Cys Asp Leu Thr Asn Glu Thr Leu Asp Pro Tyr Glu 
                           85                               90                              95      


Leu Tyr Tyr Gly Arg Val Met Thr Ala Cys Ala Gly Arg His Ser Ala 
                    100                            105                           110         


Trp Thr Arg Thr Pro Arg Phe Thr Pro Trp Trp Glu Thr Lys Leu Asp 
             115                            120                           125             


Pro Pro Val Val Thr Ile Thr Arg Val Asn Ala Ser Leu Arg Val Leu 
      130                         135                           140                 


Leu Arg Pro Pro Glu Leu Pro Asn Arg Asn Gln Ser Gly Lys Asn Ala 
145                           150                             155                          160 


Ser Met Glu Thr Tyr Tyr Gly Leu Val Tyr Arg Val Phe Thr Ile Asn 
                          165                            170                          175     


Asn Ser Leu Glu Lys Glu Gln Lys Ala Tyr Glu Gly Thr Gln Arg Ala 
                    180                           185                          190         


Val Glu Ile Glu Gly Leu Ile Pro His Ser Ser Tyr Cys Val Val Ala 
            195                         200                         205             


Glu Met Tyr Gln Pro Met Phe Asp Arg Arg Ser Pro Arg Ser Lys Glu 
       210                           215                            220                 


Arg Cys Val His Ile Pro 
225                         230 


<210>  2
<211>  263
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Met Pro Lys His Cys Phe Leu Gly Phe Leu Ile Ser Phe Phe Leu 
1                          5                              10                            15      


Thr Gly Val Ala Gly Thr Gln Ser Thr His Glu Ser Leu Lys Pro Gln 
                    20                            25                            30          


Arg Val Gln Phe Gln Ser Arg Asn Phe His Asn Ile Leu Gln Trp Gln 
              35                            40                            45              


Pro Gly Arg Ala Leu Thr Gly Asn Ser Ser Val Tyr Phe Val Gln Tyr 
       50                             55                             60                  


Lys Ile Met Phe Ser Cys Ser Met Lys Ser Ser His Gln Lys Pro Ser 
65                           70                             75                            80  


Gly Cys Trp Gln His Ile Ser Cys Asn Phe Pro Gly Cys Arg Thr Leu 
                           85                           90                              95      


Ala Lys Tyr Gly Gln Arg Gln Trp Lys Asn Lys Glu Asp Cys Trp Gly 
                   100                            105                            110         


Thr Gln Glu Leu Ser Cys Asp Leu Thr Ser Glu Thr Ser Asp Ile Gln 
             115                            120                          125             


Glu Pro Tyr Tyr Gly Arg Val Arg Ala Ala Ser Ala Gly Ser Tyr Ser 
      130                            135                         140                 


Glu Trp Ser Met Thr Pro Arg Phe Thr Pro Trp Trp Glu Thr Lys Ile 
145                           150                           155                           160 


Asp Pro Pro Val Met Asn Ile Thr Gln Val Asn Gly Ser Leu Leu Val 
                          165                          170                           175     


Ile Leu His Ala Pro Asn Leu Pro Tyr Arg Tyr Gln Lys Glu Lys Asn 
                 180                            185                           190         


Val Ser Ile Glu Asp Tyr Tyr Glu Leu Leu Tyr Arg Val Phe Ile Ile 
           195                           200                            205             


Asn Asn Ser Leu Glu Lys Glu Gln Lys Val Tyr Glu Gly Ala His Arg 
       210                           215                           220                 


Ala Val Glu Ile Glu Ala Leu Thr Pro His Ser Ser Tyr Cys Val Val 
225                         230                          235                          240 


Ala Glu Ile Tyr Gln Pro Met Leu Asp Arg Arg Ser Gln Arg Ser Glu 
                         245                            250                           255     
 

Glu Arg Cys Val Glu Ile Pro 
                     260             


<210>  3
<211>  231
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Met Pro Lys His Cys Phe Leu Gly Phe Leu Ile Ser Phe Phe Leu 
1                         5                               10                            15      


Thr Gly Val Ala Gly Thr Gln Ser Thr His Glu Ser Leu Lys Pro Gln 
                    20                            25                            30          


Arg Val Gln Phe Gln Ser Arg Asn Phe His Asn Ile Leu Gln Trp Gln 
             35                             40                            45              


Pro Gly Arg Ala Leu Thr Gly Asn Ser Ser Val Tyr Phe Val Gln Tyr 
      50                              55                            60                  


Lys Ile Tyr Gly Gln Arg Gln Trp Lys Asn Lys Glu Asp Cys Trp Gly 
65                            70                              75                              80  


Thr Gln Glu Leu Ser Cys Asp Leu Thr Ser Glu Thr Ser Asp Ile Gln 
                           85                              90                            95      


Glu Pro Tyr Tyr Gly Arg Val Arg Ala Ala Ser Ala Gly Ser Tyr Ser 
                   100                            105                         110         


Glu Trp Ser Met Thr Pro Arg Phe Thr Pro Trp Trp Glu Thr Lys Ile 
             115                           120                           125             


Asp Pro Pro Val Met Asn Ile Thr Gln Val Asn Gly Ser Leu Leu Val 
       130                          135                          140                 


Ile Leu His Ala Pro Asn Leu Pro Tyr Arg Tyr Gln Lys Glu Lys Asn 
145                        150                             155                           160 


Val Ser Ile Glu Asp Tyr Tyr Glu Leu Leu Tyr Arg Val Phe Ile Ile 
                        165                            170                           175     


Asn Asn Ser Leu Glu Lys Glu Gln Lys Val Tyr Glu Gly Ala His Arg 
                   180                            185                           190         


Ala Val Glu Ile Glu Ala Leu Thr Pro His Ser Ser Tyr Cys Val Val 
            195                          200                         205             


Ala Glu Ile Tyr Gln Pro Met Leu Asp Arg Arg Ser Gln Arg Ser Glu 
      210                          215                             220                 


Glu Arg Cys Val Glu Ile Pro 
225                           230     


<210>  4
<211>  130
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Met Pro Lys His Cys Phe Leu Gly Phe Leu Ile Ser Phe Phe Leu 
1                         5                               10                            15      


Thr Gly Val Ala Gly Thr Gln Ser Thr His Glu Ser Leu Lys Pro Gln 
                    20                             25                           30          


Arg Val Gln Phe Gln Ser Arg Asn Phe His Asn Ile Leu Gln Trp Gln 
              35                             40                           45              


Pro Gly Arg Ala Leu Thr Gly Asn Ser Ser Val Tyr Phe Val Gln Tyr 
      50                              55                            60                  


Lys Ile Tyr Gly Gln Arg Gln Trp Lys Asn Lys Glu Asp Cys Trp Gly 
65                            70                              75                              80  


Thr Gln Glu Leu Ser Cys Asp Leu Thr Ser Glu Thr Ser Asp Ile Gln 
                           85                              90                            95      


Glu Pro Tyr Tyr Gly Arg Val Arg Ala Ala Ser Ala Gly Ser Tyr Ser 
                   100                            105                         110         


Glu Trp Ser Met Thr Pro Arg Phe Thr Pro Trp Trp Glu Arg Ala Lys 
             115                           120                           125             


Gly Leu 
      130 


<210>  5
<211>  22
<212>  DNA
<213>  synthesized

<400>  5
atgatgccta agcattgcct tc                                              22


<210>  6
<211>  24
<212>  DNA
<213>  synthesized

<400>  6
tcagaccttc aatttcaaca gctc                                            24


<210>  7
<211>  28
<212>  DNA
<213>  synthesized

<400>  7
cggggtacca aggtccgatt tcagtcca                                        28


<210>  8
<211>  29
<212>  DNA
<213>  synthesized

<400>  8
gcggccgctc aagtcacgac cggaggatc                                       29


<210>  9
<211>  27
<212>  DNA
<213>  synthesized

<400>  9
cggggtacct ctttgcgggt gcttctc                                         27


<210>  10
<211>  29
<212>  DNA
<213>  synthesized

<400>  10
gcggccgctc acatttcagc cactacgca                                       29


<210>  11
<211>  309
<212>  DNA
<213>  Mus musculus

<400>  11
aaggtccgat ttcagtccag aaatttccac aatattttgc actggcaagc tgggagctct     60

ctccccagca acaacagcat ctactttgtg cagtacaaga tgtatggaca gagccaatgg    120

gaagataaag ttgactgctg ggggaccacg gcgctcttct gtgacctgac caatgaaacc    180

ttagacccat acgagctgta ttacgggagg gtgatgacgg cctgtgctgg acgccactct    240

gcctggacca ggacaccccg cttcactcca tggtgggaaa caaaactaga tcctccggtc    300

gtgacttga                                                            309


<210>  12
<211>  102
<212>  PRT
<213>  Mus musculus

<400>  12

Lys Val Arg Phe Gln Ser Arg Asn Phe His Asn Ile Leu His Trp Gln 
1                         5                               10                           15      


Ala Gly Ser Ser Leu Pro Ser Asn Asn Ser Ile Tyr Phe Val Gln Tyr 
                   20                            25                            30          


Lys Met Tyr Gly Gln Ser Gln Trp Glu Asp Lys Val Asp Cys Trp Gly 
              35                             40                             45              


Thr Thr Ala Leu Phe Cys Asp Leu Thr Asn Glu Thr Leu Asp Pro Tyr 
       50                             55                               60                  


Glu Leu Tyr Tyr Gly Arg Val Met Thr Ala Cys Ala Gly Arg His Ser 
65                              70                             75                             80  


Ala Trp Thr Arg Thr Pro Arg Phe Thr Pro Trp Trp Glu Thr Lys Leu 
                           85                             90                             95      


Asp Pro Pro Val Val Thr 
                   100         


<210>  13
<211>  216
<212>  DNA
<213>  Mus musculus

<400>  13
tctttgcggg tgcttctccg tcctccagag ttgccaaata gaaaccaaag tggaaaaaat     60

gcatccatgg aaacttacta cggcttagta tacagagttt tcacaatcaa caattcacta    120

gagaaggagc aaaaagccta tgaaggaact cagagagctg ttgaaattga aggtctgatg    180

cctcattcca gctactgcgt agtggctgaa atgtga                              216


<210>  14
<211>  71
<212>  PRT
<213>  Mus musculus

<400>  14

Ser Leu Arg Val Leu Leu Arg Pro Pro Glu Leu Pro Asn Arg Asn Gln 
1                         5                               10                              15      


Ser Gly Lys Asn Ala Ser Met Glu Thr Tyr Tyr Gly Leu Val Tyr Arg 
                   20                              25                             30          


Val Phe Thr Ile Asn Asn Ser Leu Glu Lys Glu Gln Lys Ala Tyr Glu 
             35                            40                              45              


Gly Thr Gln Arg Ala Val Glu Ile Glu Gly Leu Met Pro His Ser Ser 
       50                             55                            60                  


Tyr Cys Val Val Ala Glu Met 
65                             70      


