                         SEQUENCE LISTING

<110>  Eli Lilly and Company
 
<120>  Treatment of Migraine with Anti-CGRP Antibodies

<130>  X17257

<160>  42    

<170>  PatentIn version 3.3

<210>  1
<211>  37
<212>  PRT
<213>  Homo sapiens

<400>  1

Ala Cys Asp Thr Ala Thr Cys Val Thr His Arg Leu Ala Gly Leu Leu 
1               5                   10                  15      


Ser Arg Ser Gly Gly Val Val Lys Asn Asn Phe Val Pro Thr Asn Val 
            20                  25                  30          


Gly Ser Lys Ala Phe 
        35          


<210>  2
<211>  37
<212>  PRT
<213>  Homo sapiens

<400>  2

Ala Cys Asn Thr Ala Thr Cys Val Thr His Arg Leu Ala Gly Leu Leu 
1               5                   10                  15      


Ser Arg Ser Gly Gly Met Val Lys Ser Asn Phe Val Pro Thr Asn Val 
            20                  25                  30          


Gly Ser Lys Ala Phe 
        35          


<210>  3
<211>  37
<212>  PRT
<213>  Rattus sp.

<400>  3

Ser Cys Asn Thr Ala Thr Cys Val Thr His Arg Leu Ala Gly Leu Leu 
1               5                   10                  15      


Ser Arg Ser Gly Gly Val Val Lys Asp Asn Phe Val Pro Thr Asn Val 
            20                  25                  30          


Gly Ser Glu Ala Phe 
        35          


<210>  4
<211>  37
<212>  PRT
<213>  Rattus sp.

<400>  4

Ser Cys Asn Thr Ala Thr Cys Val Thr His Arg Leu Ala Gly Leu Leu 
1               5                   10                  15      


Ser Arg Ser Gly Gly Val Val Lys Asp Asn Phe Val Pro Thr Asn Val 
            20                  25                  30          


Gly Ser Lys Ala Phe 
        35          


<210>  5
<211>  37
<212>  PRT
<213>  Homo sapiens

<400>  5

Lys Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu 
1               5                   10                  15      


Val His Ser Ser Asn Asn Phe Gly Ala Ile Leu Ser Ser Thr Asn Val 
            20                  25                  30          


Gly Ser Asn Thr Tyr 
        35          


<210>  6
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  6

Cys Gly Asn Leu Ala Ser Thr Cys Met Leu Gly Thr Tyr Thr Gln Asp 
1               5                   10                  15      


Phe Asn Lys Phe Phe Pro Gln Thr Ala Ile Gly Val Gly Ala Pro 
            20                  25                  30      


<210>  7
<211>  52
<212>  PRT
<213>  Homo sapiens

<400>  7

Tyr Arg Gln Ser Met Asn Asn Phe Gln Gly Leu Arg Ser Phe Gly Cys 
1               5                   10                  15      


Arg Phe Gly Thr Cys Thr Val Gln Lys Leu Ala His Gln Ile Tyr Gln 
            20                  25                  30          


Phe Thr Asp Lys Asp Lys Asp Asn Val Ala Pro Arg Ser Lys Ile Ser 
        35                  40                  45              


Pro Gln Gly Tyr 
    50          


<210>  8
<211>  13
<212>  PRT
<213>  Mus musculus

<400>  8

Cys Lys Ala Ser Gln Asn Val Gly Thr Asn Val Ala Trp 
1               5                   10              


<210>  9
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  9

Ser Ala Ser Tyr Arg Tyr Ser 
1               5           


<210>  10
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  10

Gln Gln Tyr Ser Ser Tyr Pro Phe Thr 
1               5                   


<210>  11
<211>  14
<212>  PRT
<213>  Mus musculus

<400>  11

Cys Ser Ala Ser Ser Ser Ile Ser Ser Ile Tyr Leu His Trp 
1               5                   10                  


<210>  12
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  12

Arg Ala Ser Asn Leu Ala Ser 
1               5           


<210>  13
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  13

Gln Gln Gly Ser Thr Ile Pro Phe Thr 
1               5                   


<210>  14
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  14

Gly Tyr Thr Ser Thr Thr Tyr Trp Ile His 
1               5                   10  


<210>  15
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  15

Asn Ile Asn Pro Asp Ser Gly Ser Thr Asp Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Ser 
    


<210>  16
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  16

Asp Gly Tyr Tyr Ala Met Asn Tyr 
1               5               


<210>  17
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  17

Gly Tyr Thr Ser Pro Thr Tyr Trp Ile His 
1               5                   10  


<210>  18
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  18

Gly Tyr Thr Ser Thr Thr Tyr Trp Ile His 
1               5                   10  


<210>  19
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  19

Asn Ile Asn Pro Asp Ser Gly Ser Thr Asp Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  20
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  20

Asn Ile Asn Pro Asp Ser Gly Ser Thr Asp Tyr Asn Glu Glu Phe Lys 
1               5                   10                  15      


Ser 
    


<210>  21
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  21

Asp Gly His Tyr Ala Met Asn Tyr 
1               5               


<210>  22
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  22

Gly Tyr Thr Phe Thr Ser Ser Val Met His 
1               5                   10  


<210>  23
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  23

Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  24
<211>  6
<212>  PRT
<213>  Mus musculus

<400>  24

Gly Gly Asn Asp Gly Tyr 
1               5       


<210>  25
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa at position 4 is S or F

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa at position 5 is T or P

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa at position 6 is T or S

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa at position 7 is Y or S

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa at position 8 is W or V

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa at position 9 is I or M

<400>  25

Gly Tyr Thr Xaa Xaa Xaa Xaa Xaa Xaa His 
1               5                   10  


<210>  26
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is N or Y

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa at position 5 is D or Y

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa at position 6 is S or N

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa at position 7 is G or D

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa at position 8 is G or S

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa at position 10 is D or K

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa at position 14 is Kor E

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa at position 17 is S or G

<400>  26

Xaa Ile Asn Pro Xaa Xaa Xaa Xaa Thr Xaa Tyr Asn Glu Xaa Phe Lys 
1               5                   10                  15      


Xaa 
    


<210>  27
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is D or G

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa at position 3 is H, Y or N

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa at position 4 is D or Y

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa at position 5 is A or G

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa at position 6 is M or absent

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa at position 7 is N or absent

<400>  27

Xaa Gly Xaa Xaa Xaa Xaa Xaa Tyr 
1               5               


<210>  28
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  28

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Met Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Ser Ser Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Arg Leu Glu Ile Lys 
            100                 105         


<210>  29
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  29

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Ala Asp Phe Thr Leu Thr Ile Ser Asn Met Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Ser Ser Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Arg Leu Glu Ile Lys 
            100                 105         


<210>  30
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  30

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Met Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Ser Ser Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Arg Leu Glu Ile Lys 
            100                 105         


<210>  31
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  31

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Met Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Ser Ser Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Arg Leu Glu Ile Lys 
            100                 105         


<210>  32
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  32

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Met Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Ser Ser Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Arg Leu Glu Ile Lys 
            100                 105         


<210>  33
<211>  108
<212>  PRT
<213>  Mus musculus

<400>  33

Glu Ile Val Leu Thr Gln Ser Pro Thr Thr Met Ala Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Ile Thr Ile Thr Cys Ser Ala Ser Ser Ser Ile Ser Ser Ile 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Phe Ser Pro Lys Val Leu 
        35                  40                  45              


Ile Tyr Arg Ala Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Gly Thr Met Glu 
65                  70                  75                  80  


Ala Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Gly Ser Thr Ile Pro 
                85                  90                  95      


Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  34
<211>  117
<212>  PRT
<213>  Mus musculus

<400>  34

Gln Val Gln Val Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Ser Thr Thr Tyr 
            20                  25                  30          


Trp Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asn Pro Asp Ser Gly Ser Thr Asp Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Trp Tyr Asp Gly Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  35
<211>  117
<212>  PRT
<213>  Mus musculus

<400>  35

Gln Val Gln Val Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Ser Pro Thr Tyr 
            20                  25                  30          


Trp Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asn Pro Asp Ser Gly Ser Thr Asp Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Trp Tyr Asp Gly Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  36
<211>  117
<212>  PRT
<213>  Mus musculus

<400>  36

Gln Val Gln Val Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Ser Thr Thr Tyr 
            20                  25                  30          


Trp Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asn Pro Asp Ser Gly Ser Thr Asp Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Trp Tyr Asp Gly Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  37
<211>  117
<212>  PRT
<213>  Mus musculus

<400>  37

Gln Val Gln Val Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Ser Thr Thr Tyr 
            20                  25                  30          


Trp Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asn Pro Asp Ser Gly Ser Thr Asp Tyr Asn Glu Glu Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Trp Tyr Asp Gly Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  38
<211>  117
<212>  PRT
<213>  Mus musculus

<400>  38

Gln Val Gln Val Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Ser Thr Thr Tyr 
            20                  25                  30          


Trp Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asn Pro Asp Ser Gly Ser Thr Asp Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Trp Tyr Asp Gly His Tyr Ala Met Asn Tyr Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  39
<211>  115
<212>  PRT
<213>  Mus musculus

<400>  39

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Ser 
            20                  25                  30          


Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Gly Asn Asp Gly Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  40
<211>  324
<212>  PRT
<213>  Mus musculus

<400>  40

Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala 
1               5                   10                  15      


Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu 
    50                  55                  60                  


Ser Ser Ser Val Thr Val Pro Ser Ser Thr Trp Pro Ser Glu Thr Val 
65                  70                  75                  80  


Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys 
                85                  90                  95      


Ile Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro 
            100                 105                 110         


Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu 
        115                 120                 125             


Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser 
    130                 135                 140                 


Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu 
145                 150                 155                 160 


Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr 
                165                 170                 175     


Phe Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn 
            180                 185                 190         


Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro 
        195                 200                 205             


Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln 
    210                 215                 220                 


Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val 
225                 230                 235                 240 


Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val 
                245                 250                 255     


Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln 
            260                 265                 270         


Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn 
        275                 280                 285             


Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val 
    290                 295                 300                 


Leu His Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser His 
305                 310                 315                 320 


Ser Pro Gly Lys 
                


<210>  41
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  41

Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu 
1               5                   10                  15      


Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg 
        35                  40                  45              


Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu 
65                  70                  75                  80  


Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser 
                85                  90                  95      


Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
            100                 105         


<210>  42
<211>  816
<212>  DNA
<213>  Homo sapiens

<400>  42
ccgccgctgc caccgcctct gatccaagcc acctcccgcc aggtgagccc cgagattctg     60

gctcagagag gtgtcatggg cttccaaaag ttctccccct tcctggctct cagcatcttg    120

gtcctgttgc aggcaggcag cctccatgca gcaccattca ggtctgccct ggagagcagc    180

ccagcagacc cggccacgct cagtgaggac gaagcgcgcc tcctgctggc tgcactggtg    240

caggactatg tgcagatgaa ggccagtgag ctggagcagg agcaagagag agagggctcc    300

agcctggaca gccccagatc taagcggtgc ggtaatctga gtacttgcat gctgggcaca    360

tacacgcagg acttcaacaa gtttcacacg ttcccccaaa ctgcaattgg ggttggagca    420

cctggaaaga aaagggatat gtccagcgac ttggagagag accatcgccc tcatgttagc    480

atgccccaga atgccaacta aactcctccc tttccttcct aatttccctt cttgcatcct    540

tcctataact tgatgcatgt ggtttggttc ctctctggtg gctctttggg ctggtattgg    600

tggctttcct tgtggcagag gatgtctcaa acttcagatg ggaggaaaga gagcaggact    660

cacaggttgg aagagaatca cctgggaaaa taccagaaaa tgagggccgc tttgagtccc    720

ccagagatgt catcagagct cctctgtcct gcttctgaat gtgctgatca tttgaggaat    780

aaaattattt ttccccaaaa aaaaaaaaaa aaaaaa                              816


