                         SEQUENCE LISTING

<110>  Leiden University Medical Center
 
<120>  hECGF-1 related polymorphisms and applications thereof

<130>  P6001572 EP

<160>  8     

<170>  PatentIn version 3.3

<210>  1
<211>  482
<212>  PRT
<213>  homo sapiens

<400>  1

Met Ala Ala Leu Met Thr Pro Gly Thr Gly Ala Pro Pro Ala Pro Gly 
1               5                   10                  15      


Asp Phe Ser Gly Glu Gly Ser Gln Gly Leu Pro Asp Pro Ser Pro Glu 
            20                  25                  30          


Pro Lys Gln Leu Pro Glu Leu Ile Arg Met Lys Arg Asp Gly Gly Arg 
        35                  40                  45              


Leu Ser Glu Ala Asp Ile Arg Gly Phe Val Ala Ala Val Val Asn Gly 
    50                  55                  60                  


Ser Ala Gln Gly Ala Gln Ile Gly Ala Met Leu Met Ala Ile Arg Leu 
65                  70                  75                  80  


Arg Gly Met Asp Leu Glu Glu Thr Ser Val Leu Thr Gln Ala Leu Ala 
                85                  90                  95      


Gln Ser Gly Gln Gln Leu Glu Trp Pro Glu Ala Trp Arg Gln Gln Leu 
            100                 105                 110         


Val Asp Lys His Ser Thr Gly Gly Val Gly Asp Lys Val Ser Leu Val 
        115                 120                 125             


Leu Ala Pro Ala Leu Ala Ala Cys Gly Cys Lys Val Pro Met Ile Ser 
    130                 135                 140                 


Gly Arg Gly Leu Gly His Thr Gly Gly Thr Leu Asp Lys Leu Glu Ser 
145                 150                 155                 160 


Ile Pro Gly Phe Asn Val Ile Gln Ser Pro Glu Gln Met Gln Val Leu 
                165                 170                 175     


Leu Asp Gln Ala Gly Cys Cys Ile Val Gly Gln Ser Glu Gln Leu Val 
            180                 185                 190         


Pro Ala Asp Gly Ile Leu Tyr Ala Ala Arg Asp Val Thr Ala Thr Val 
        195                 200                 205             


Asp Ser Leu Pro Leu Ile Thr Ala Ser Ile Leu Ser Lys Lys Leu Val 
    210                 215                 220                 


Glu Gly Leu Ser Ala Leu Val Val Asp Val Lys Phe Gly Gly Ala Ala 
225                 230                 235                 240 


Val Phe Pro Asn Gln Glu Gln Ala Arg Glu Leu Ala Lys Thr Leu Val 
                245                 250                 255     


Gly Val Gly Ala Ser Leu Gly Leu Arg Val Ala Ala Ala Leu Thr Ala 
            260                 265                 270         


Met Asp Lys Pro Leu Gly Arg Cys Val Gly His Ala Leu Glu Val Glu 
        275                 280                 285             


Glu Ala Leu Leu Cys Met Asp Gly Ala Gly Pro Pro Asp Leu Arg Asp 
    290                 295                 300                 


Leu Val Thr Thr Leu Gly Gly Ala Leu Leu Trp Leu Ser Gly His Ala 
305                 310                 315                 320 


Gly Thr Gln Ala Gln Gly Ala Ala Arg Val Ala Ala Ala Leu Asp Asp 
                325                 330                 335     


Gly Ser Ala Leu Gly Arg Phe Glu Arg Met Leu Ala Ala Gln Gly Val 
            340                 345                 350         


Asp Pro Gly Leu Ala Arg Ala Leu Cys Ser Gly Ser Pro Ala Glu Arg 
        355                 360                 365             


Arg Gln Leu Leu Pro Arg Ala Arg Glu Gln Glu Glu Leu Leu Ala Pro 
    370                 375                 380                 


Ala Asp Gly Thr Val Glu Leu Val Arg Ala Leu Pro Leu Ala Leu Val 
385                 390                 395                 400 


Leu His Glu Leu Gly Ala Gly Arg Ser Arg Ala Gly Glu Pro Leu Arg 
                405                 410                 415     


Leu Gly Val Gly Ala Glu Leu Leu Val Asp Val Gly Gln Arg Leu Arg 
            420                 425                 430         


Arg Gly Thr Pro Trp Leu Arg Val His Arg Asp Gly Pro Ala Leu Ser 
        435                 440                 445             


Gly Pro Gln Ser Arg Ala Leu Gln Glu Ala Leu Val Leu Ser Asp Arg 
    450                 455                 460                 


Ala Pro Phe Ala Ala Pro Ser Pro Phe Ala Glu Leu Val Leu Pro Pro 
465                 470                 475                 480 


Gln Gln 
        


<210>  2
<211>  482
<212>  PRT
<213>  homo sapiens

<400>  2

Met Ala Ala Leu Met Thr Pro Gly Thr Gly Ala Pro Pro Ala Pro Gly 
1               5                   10                  15      


Asp Phe Ser Gly Glu Gly Ser Gln Gly Leu Pro Asp Pro Ser Pro Glu 
            20                  25                  30          


Pro Lys Gln Leu Pro Glu Leu Ile Arg Met Lys Arg Asp Gly Gly Arg 
        35                  40                  45              


Leu Ser Glu Ala Asp Ile Arg Gly Phe Val Ala Ala Val Val Asn Gly 
    50                  55                  60                  


Ser Ala Gln Gly Ala Gln Ile Gly Ala Met Leu Met Ala Ile Arg Leu 
65                  70                  75                  80  


Arg Gly Met Asp Leu Glu Glu Thr Ser Val Leu Thr Gln Ala Leu Ala 
                85                  90                  95      


Gln Ser Gly Gln Gln Leu Glu Trp Pro Glu Ala Trp Arg Gln Gln Leu 
            100                 105                 110         


Val Asp Lys His Ser Thr Gly Gly Val Gly Asp Lys Val Ser Leu Val 
        115                 120                 125             


Leu Ala Pro Ala Leu Ala Ala Cys Gly Cys Lys Val Pro Met Ile Ser 
    130                 135                 140                 


Gly Arg Gly Leu Gly His Thr Gly Gly Thr Leu Asp Lys Leu Glu Ser 
145                 150                 155                 160 


Ile Pro Gly Phe Asn Val Ile Gln Ser Pro Glu Gln Met Gln Val Leu 
                165                 170                 175     


Leu Asp Gln Ala Gly Cys Cys Ile Val Gly Gln Ser Glu Gln Leu Val 
            180                 185                 190         


Pro Ala Asp Gly Ile Leu Tyr Ala Ala Arg Asp Val Thr Ala Thr Val 
        195                 200                 205             


Asp Ser Leu Pro Leu Ile Thr Ala Ser Ile Leu Ser Lys Lys Leu Val 
    210                 215                 220                 


Glu Gly Leu Ser Ala Leu Val Val Asp Val Lys Phe Gly Gly Ala Ala 
225                 230                 235                 240 


Val Phe Pro Asn Gln Glu Gln Ala Arg Glu Leu Ala Lys Thr Leu Val 
                245                 250                 255     


Gly Val Gly Ala Ser Leu Gly Leu Arg Val Ala Ala Ala Leu Thr Ala 
            260                 265                 270         


Met Asp Lys Pro Leu Gly Arg Cys Val Gly His Ala Leu Glu Val Glu 
        275                 280                 285             


Glu Ala Leu Leu Cys Met Asp Gly Ala Gly Pro Pro Asp Leu Arg Asp 
    290                 295                 300                 


Leu Val Thr Thr Leu Gly Gly Ala Leu Leu Trp Leu Ser Gly His Ala 
305                 310                 315                 320 


Gly Thr Gln Ala Gln Gly Ala Ala Arg Val Ala Ala Ala Leu Asp Asp 
                325                 330                 335     


Gly Ser Ala Leu Gly Arg Phe Glu Arg Met Leu Ala Ala Gln Gly Val 
            340                 345                 350         


Asp Pro Gly Leu Ala Arg Ala Leu Cys Ser Gly Ser Pro Ala Glu Arg 
        355                 360                 365             


Arg Gln Leu Leu Pro Arg Ala Arg Glu Gln Glu Glu Leu Leu Ala Pro 
    370                 375                 380                 


Ala Asp Gly Thr Val Glu Leu Val Arg Ala Leu Pro Leu Ala Leu Val 
385                 390                 395                 400 


Leu His Glu Leu Gly Ala Gly Arg Ser Arg Ala Gly Glu Pro Leu Arg 
                405                 410                 415     


Leu Gly Val Gly Ala Glu Leu Leu Val Asp Val Gly Gln Arg Leu Arg 
            420                 425                 430         


Arg Gly Thr Pro Trp Leu Arg Val His Arg Asp Gly Pro Ala Leu Ser 
        435                 440                 445             


Gly Pro Gln Ser Arg Ala Leu Gln Glu Ala Leu Val Leu Ser Asp Arg 
    450                 455                 460                 


Thr Pro Phe Ala Ala Pro Ser Pro Phe Ala Glu Leu Val Leu Pro Pro 
465                 470                 475                 480 


Gln Gln 
        


<210>  3
<211>  48
<212>  PRT
<213>  homo sapiens

<400>  3

Leu Ala Pro Arg Ala Pro Gly Arg Pro Arg Ala Gln Arg Pro Ala Glu 
1               5                   10                  15      


Pro Arg Pro Ala Gly Gly Ala Arg Thr Leu Arg Pro Arg Ala Ile Arg 
            20                  25                  30          


Arg Pro Leu Ala Leu Arg Arg Ala Arg Ser Ala Ala Ala Ala Ile Lys 
        35                  40                  45              


<210>  4
<211>  48
<212>  PRT
<213>  homo sapiens

<400>  4

Leu Ala Pro Arg Ala Pro Gly Arg Pro Arg Ala Gln Arg Pro Ala Glu 
1               5                   10                  15      


Pro Arg Pro Ala Gly Gly Ala Arg Thr Leu Arg Pro His Ala Ile Arg 
            20                  25                  30          


Arg Pro Leu Ala Leu Arg Arg Ala Arg Ser Ala Ala Ala Ala Ile Lys 
        35                  40                  45              


<210>  5
<211>  11
<212>  PRT
<213>  homo sapiens

<400>  5

Arg Pro Arg Ala Ile Arg Arg Pro Leu Ala Leu 
1               5                   10      


<210>  6
<211>  11
<212>  PRT
<213>  homo sapiens

<400>  6

Arg Pro His Ala Ile Arg Arg Pro Leu Ala Leu 
1               5                   10      


<210>  7
<211>  1600
<212>  DNA
<213>  homo sapiens

<400>  7
gccccgccgc cggcagtgga ccgctgtgcg cgaaccctga accctacggt cccgacccgc     60

gggcgaggcc gggtacctgg gctgggatcc ggagcaagcg ggcgagggca gcgccctaag    120

caggcccgga gcgatggcag ccttgatgac cccgggaacc ggggccccac ccgcgcctgg    180

tgacttctcc ggggaaggga gccagggact tcccgaccct tcgccagagc ccaagcagct    240

cccggagctg atccgcatga agcgagacgg aggccgcctg agcgaagcgg acatcagggg    300

cttcgtggcc gctgtggtga atgggagcgc gcagggcgca cagatcgggg ccatgctgat    360

ggccatccga cttcggggca tggatctgga ggagacctcg gtgctgaccc aggccctggc    420

tcagtcggga cagcagctgg agtggccaga ggcctggcgc cagcagcttg tggacaagca    480

ttccacaggg ggtgtgggtg acaaggtcag cctggtcctc gcacctgccc tggcggcatg    540

tggctgcaag gtgccaatga tcagcggacg tggtctgggg cacacaggag gcaccttgga    600

taagctggag tctattcctg gattcaatgt catccagagc ccagagcaga tgcaagtgct    660

gctggaccag gcgggctgct gtatcgtggg tcagagtgag cagctggttc ctgcggacgg    720

aatcctatat gcagccagag atgtgacagc caccgtggac agcctgccac tcatcacagc    780

ctccattctc agtaagaaac tcgtggaggg gctgtccgct ctggtggtgg acgttaagtt    840

cggaggggcc gccgtcttcc ccaaccagga gcaggcccgg gagctggcaa agacgctggt    900

tggcgtggga gccagcctag ggcttcgggt cgcggcagcg ctgaccgcca tggacaagcc    960

cctgggtcgc tgcgtgggcc acgccctgga ggtggaggag gcgctgctct gcatggacgg   1020

cgcaggcccg ccagacttaa gggacctggt caccacgctc gggggcgccc tgctctggct   1080

cagcggacac gcggggactc aggctcaggg cgctgcccgg gtggccgcgg cgctggacga   1140

cggctcggcc cttggccgct tcgagcggat gctggcggcg cagggcgtgg atcccggtct   1200

ggcccgagcc ctgtgctcgg gaagtcccgc agaacgccgg cagctgctgc ctcgcgcccg   1260

ggagcaggag gagctgctgg cgcccgcaga tggcaccgtg gagctggtcc gggcgctgcc   1320

gctggcgctg gtgctgcacg agctcggggc cgggcgcagc cgcgctgggg agccgctccg   1380

cctgggggtg ggcgcagagc tgctggtcga cgtgggtcag aggctgcgcc gtgggacccc   1440

ctggctccgc gtgcaccggg acggccccgc gctcagcggc ccgcagagcc gcgccctgca   1500

ggaggcgctc gtactctccg accgcgcgcc attcgccgcc ccctcgccct tcgcagagct   1560

cgttctgccg ccgcagcaat aaagctcctt tgccgcgaaa                         1600


<210>  8
<211>  5845
<212>  DNA
<213>  homo sapiens

<400>  8
gatattcggt accccatatc cggatctcaa atcccaaacc ccgaacccca cggggctttg     60

ataaatcgtg gctcagactc cccactagtc ccaggacccc atctcgggta cccaccaggc    120

tcccacgcag ttctagcccc ccacaccctt gatccgcccc gcaggcaggt acttcccgga    180

gcgagcgggg aacgcgacgt accccagtgc gcctcggcac accattgctc cccgaaactg    240

gggtgtccag gcggaacagc agagcccagg tgaggtcaga acggcccatc ccagaactgt    300

gggccttccc actcgagacc ggggaccgcc ctccgggagc tgggaccacc ctgcgcctgt    360

ccgcggagac ccactacccc cgagccctgc ctcctcccca ggtcccgcgg cctatacggt    420

gccctcgctc ttgggtccgc gcgtcatcgg caaagtctcc gccccaactt gctccatcta    480

cggccgcaga gcggctggca gtttcttcga ggacctcagc aaggtggggg aggggccggg    540

gcggacgcag ggggtccctg gtccgcggca gtggaggcgg cagccagcac cctctgccct    600

ctcgcagacc ccgggcccct gcgcctatca ggtcgtgagt ccaggggtct acaagtcccg    660

ggccccccag ttcacgattc tggcgcggac ttcgctcccc caagacaaca ctcggaagcc    720

agggcccgcg gcctacaacg tggatcaggt ggcctggagc ccagggtcaa gggtcagagt    780

caggagagtg gggagggcct gaggtcggag tgatgggatc agagtccccg ggggtccagg    840

ggtcccggcg cggagaggat gccggccccg cgaggtcagc ggtgtctccg ggcccgcagc    900

accggaagcc ccgcggctgg agtttcggga tccggcactc ggactacctg gccccgctgg    960

tgaccgacgc ggacaactga cccgccaggc gggagcggcc ccacacgtgt ttgcttaaag   1020

tctgcgagtc cgcatcgtgt ccgcctctct ctctctctct ctgcgcgtcc tggcgcaagg   1080

cctggggtgg agccacggct ggggccgtgt cccaactccg aacccagcgg ggcggggccc   1140

gagcgtcggg cgaggccggg accccagcgc tgcgccgcgt ccgaacgtcg agaccccacc   1200

gagggcggga gggggactct cgggagccac agacgcccga gacccacgcc gggcgggacc   1260

ggccagggat cacccccgcc gacggccccg ggccccgacg gcccggaagt tccgcgtgtc   1320

cgggggcacc gggggattgg ccggggcgcg gcgtgcaagg cttcccgggg gcggcgactg   1380

ccgagctccg ccctccaggc ggccccaccc gcctgccgtc ctggggcgcc gccgccccgc   1440

cgccggcagt ggaccgctgt gcgcgaaccc tgaaccctac ggtcccgacc cgcgggcgag   1500

gccgggtacc tgggctggga tccggagcaa gcgggcgagg gcagcgccct aagcaggtac   1560

gggcggggct caagtcgcga ggcggggaag cgggaggcag acacggacga gggcgacaca   1620

gacacgggac cgaggggcgg acaccggaga gacacgggaa aggggtcggg acaggagcac   1680

gtggctcaga caccgacgcc gggaggccgc agaccccgga cgtgtcaggc atccccgcag   1740

gcccggagcg atggcagcct tgatgacccc gggaaccggg gccccacccg cgcctggtga   1800

cttctccggg gaagggagcc agggacttcc cgacccttcg ccagagccca agcagctccc   1860

ggagctgatc cgcatgaagc gagacggagg ccgcctgagc gaagcggaca tcaggggctt   1920

cgtggccgct gtggtgaatg ggagcgcgca gggcgcacag atcggtgcgt ggggagggtt   1980

gggcgttcct gaccccgact gggaggtcag cccgagagac tttgggtccc tgggggtgcg   2040

acggtgcccc actaccagca ccggccccag ggtgccccac cgctgtgggc tgccaccctc   2100

acgcgtaccc ccacatacca ggggccatgc tgatggccat ccgacttcgg ggcatggatc   2160

tggaggagac ctcggtgctg acccaggccc tggctcagtc gggacagcag ctggagtggc   2220

cagaggcctg gcgccagcag cttgtggaca agcattccac agggggtgtg ggtgacaagg   2280

tcagcctggt cctcgcacct gccctggcgg catgtggctg caaggttaga aaccacctcc   2340

tttccagacg ggagcctata ccgcacatgc agcaaccagt ccatccacag gcagctccca   2400

acctcaagcc tggcccaaag cctccaagac cctaccaagg cttctcccca ccctgctccc   2460

cagcacagtt ctccccaccc cgttccccag cacagcgctt ggggcccctc tggctccaga   2520

ccaggcccct tggagcagga aaaagatcca ctgatggaat tcagacccct ttccccttgg   2580

gtccccagac agctccccca agggaggagc tgaggacttc cctccctctg ccccaagcct   2640

tgtttcccca aggagaggta ccaacctcct cccctactga cacttctcaa ccaagaaaac   2700

ttcctttcca ttccctcacc agctgggcac ccctatagct gcttaaatac tttccaaatc   2760

cagctgcact cctagccagg gaaggtgaag ggatgcacag aggtggggga ggggtactgt   2820

gcagggtact cagcatccct gaccaccagg tgccaatgat cagcggacgt ggtctggggc   2880

acacaggagg caccttggat aagctggagt ctattcctgg attcaatgtc atccagagcc   2940

cagagcaggt acggggcgcc acggatcagt cattgatcca ggttgatgat ccagaccctg   3000

gccagaatca ctaaaagatc actggtggat cattagggtc actaatgaga acactggtca   3060

aggttactca tgagtcactg ggcctgggcc gaaatcatca gtggaacttt gattaggatc   3120

ataaaatggg aagttggtca aaatcacaga tggctggcgg ggcacggtgg ctcacacctg   3180

tagtcctagc acttggggag gccgaagagg gcagatccct tgaacccagg agttcaaaac   3240

cagcctggat aacaaggcaa aaccccatct ctacaaaata gttcgctgcg tgtggtggtg   3300

cacgcatgtg gttccagcta ctcaggaggc tgaggcagga ggatcacttg agcctgggag   3360

gtctaggctg cagtgagccg ggacgatgcc actgcactcc agcctgggca acagagtgag   3420

accctgtccc agcactctgg gaggcagagg agcccagttg gagatcagcc tgggtaatat   3480

agtgaaactt gatctctaca aaaaaaagaa gaaaaaaaaa agccgcgtgt ggtggtgcgc   3540

acctgtagtc ccagctactg ggaagctgag gtgggaggat cacttaagcc caggaggcag   3600

aggtcacaat gagccgaaat tgtgccaact gcactccagc ctgggcaaca gaggaagact   3660

cttcacagaa aaaaaaaaaa aaaaaaagct gctaagtcat ttaccataag tcactgagaa   3720

caggggatgt ctgaccagat gcaagtgctg ctggaccagg cgggctgctg tatcgtgggt   3780

cagagtgagc agctggttcc tgcggacgga atcctatatg cagccagaga tgtgacagcc   3840

accgtggaca gcctgccact catcacaggt gacctgactc catggcctgc ttctgcatgt   3900

tcacaggctc ctgacctcca aactcaagtc aagggcctct cgttaggagt tacccgtcac   3960

ctgaccgtgt gcccccctac ccccatcaca agatgcctga ccaccaccat gtgggtggcc   4020

tgatactcaa cccaccaggt gctgccaccc ccataataag ggacttgacc ctcaatgctc   4080

agggcccctg accccaaagt cggcatcccc gaactctccc aagaagctcc aggttctcca   4140

ttgtctccaa cctcctctgc ctcccccaaa gcctccattc tcagtaagaa actcgtggag   4200

gggctgtccg ctctggtggt ggacgttaag ttcggagggg ccgccgtctt ccccaaccag   4260

gagcaggccc gggagctggc aaagacgctg gtgagcggtg tggcctttcc ctgggcaagc   4320

gtcttgatgc gggcccagcc tacccttcac ccctcccgtc cccactgcct ccctccactc   4380

agcagtcctg cctaacccca gtcccaccct cttctgcccg aagtccctcc ctccttcacg   4440

gcttcctaac ctgctgtgac tttagaggtc aaggctggcc cggcctggac ctggggaagc   4500

cctctgtggg gttcctgccc cagaccaagt acaagttcct cctggcccca tggcgaggtg   4560

tcgcacttca ctcgtgtctc ttccccaccc caatccttcc ctgacttcat gctggggggc   4620

tggcaaccca ccctgcagca ggggctggag ttcgaccaag aaccggctgc agaaggcccc   4680

gccatggggg gtccacgctg agcctcctct ccgcaggttg gcgtgggagc cagcctaggg   4740

cttcgggtcg cggcagcgct gaccgccatg gacaagcccc tgggtcgctg cgtgggccac   4800

gccctggagg tggaggaggc gctgctctgc atggacggcg caggcccgcc agacttaagg   4860

gacctggtca ccacgctcgg tgagggggac ggggtgtagg ggagcggagg cggcgggggg   4920

tgcttcccgc tggggccgcc ccgacccggc cgcgcctaag acccgtcccc gcccgcaggg   4980

ggcgccctgc tctggctcag cggacacgcg gggactcagg ctcagggcgc tgcccgggtg   5040

gccgcggcgc tggacgacgg ctcggccctt ggccgcttcg agcggatgct ggcggcgcag   5100

ggcgtggatc ccggtctgac ccgagccctg tgctcgggaa gtcccgcaga acgccggcag   5160

ctgctgcctc gcgcccggga gcaggaggag ctgctggcgc ccgcagatgg tgagcgtcgg   5220

gggagtcccc gtccttccgc ctccgccatc cccttccctt cccgaggccc cgccccttcc   5280

cgagcccgcg cctctcagcc cctctccccg caggcaccgt ggagctggtc cgggcgctgc   5340

cgctggcgct ggtgctgcac gagctcgggg ccgggcgcag ccgcgctggg gagccgctcc   5400

gcctgggggt gggcgcagag ctgctggtcg acgtgggtca gaggctgcgc cgtggtgagc   5460

gccgcccccg ccctgctggc cccgcacccc cgcccagctc cggccgcgcg gcctctaaca   5520

gcccctcgct ctgcagggac cccctggctc cgcgtgcacc gggacggccc cgcgctcagc   5580

ggcccgcaga gccgcgccct gcaggaggcg ctcgtactct ccgaccgcgc gccattcgcc   5640

gccccctcgc ccttcgcaga gctcgttctg ccgccgcagc aataaagctc ctttgccgcg   5700

aaaccttgtc agtgcttggg cgggagcgga gggatccagg gctgcggagg cgggggccgt   5760

ctcgatgaac acgtgacccc cggcgggctc cgccttccgc gcacgcgctg agagcctgtc   5820

agcggctgcg cccgtgtgcg catgc                                         5845


