                         SEQUENCE LISTING

<110>  FONDAZIONE SALVATORE MAUGERI  CLINICA DEL LAVORO E DELLA 
       RIABILITAZIONE I.R.C.C.S.
       UNIVERSITA' DEGLI STUDI DI PAVIA
 
<120>  Mutations associated with the Long QT Syndrome and diagnostic use
        thereof

<130>  6655PTWO

<150>  MI2005A001047
<151>  2005-06-07

<160>  212   

<170>  PatentIn version 3.3

<210>  1
<211>  2031
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(2031)
<223>  KvLQT1 cDNA (GenBank Acc. N AF000571): nucleotides 111 to 2141

<400>  1
atg gcc gcg gcc tcc tcc ccg ccc agg gcc gag agg aag cgc tgg ggt       48
Met Ala Ala Ala Ser Ser Pro Pro Arg Ala Glu Arg Lys Arg Trp Gly         
1               5                   10                  15              

tgg ggc cgc ctg cca ggc gcc cgg cgg ggc agc gcg ggc ctg gcc aag       96
Trp Gly Arg Leu Pro Gly Ala Arg Arg Gly Ser Ala Gly Leu Ala Lys         
            20                  25                  30                  

aag tgc ccc ttc tcg ctg gag ctg gcg gag ggc ggc ccg gcg ggc ggc      144
Lys Cys Pro Phe Ser Leu Glu Leu Ala Glu Gly Gly Pro Ala Gly Gly         
        35                  40                  45                      

gcg ctc tac gcg ccc atc gcg ccc ggc gcc cca ggt ccc gcg ccc cct      192
Ala Leu Tyr Ala Pro Ile Ala Pro Gly Ala Pro Gly Pro Ala Pro Pro         
    50                  55                  60                          

gcg tcc ccg gcc gcg ccc gcc gcg ccc cca gtt gcc tcc gac ctt ggc      240
Ala Ser Pro Ala Ala Pro Ala Ala Pro Pro Val Ala Ser Asp Leu Gly         
65                  70                  75                  80          

ccg cgg ccg ccg gtg agc cta gac ccg cgc gtc tcc att tac agc acg      288
Pro Arg Pro Pro Val Ser Leu Asp Pro Arg Val Ser Ile Tyr Ser Thr         
                85                  90                  95              

cgc cgc ccg gtg ttg gcg cgc acc cac gtc cag ggc cgc gtc tac aac      336
Arg Arg Pro Val Leu Ala Arg Thr His Val Gln Gly Arg Val Tyr Asn         
            100                 105                 110                 

ttc ctc gag cgt ccc acc ggc tgg aaa tgc ttc gtt tac cac ttc gcc      384
Phe Leu Glu Arg Pro Thr Gly Trp Lys Cys Phe Val Tyr His Phe Ala         
        115                 120                 125                     

gtc ttc ctc atc gtc ctg gtc tgc ctc atc ttc agc gtg ctg tcc acc      432
Val Phe Leu Ile Val Leu Val Cys Leu Ile Phe Ser Val Leu Ser Thr         
    130                 135                 140                         

atc gag cag tat gcc gcc ctg gcc acg ggg act ctc ttc tgg atg gag      480
Ile Glu Gln Tyr Ala Ala Leu Ala Thr Gly Thr Leu Phe Trp Met Glu         
145                 150                 155                 160         

atc gtg ctg gtg gtg ttc ttc ggg acg gag tac gtg gtc cgc ctc tgg      528
Ile Val Leu Val Val Phe Phe Gly Thr Glu Tyr Val Val Arg Leu Trp         
                165                 170                 175             

tcc gcc ggc tgc cgc agc aag tac gtg ggc ctc tgg ggg cgg ctg cgc      576
Ser Ala Gly Cys Arg Ser Lys Tyr Val Gly Leu Trp Gly Arg Leu Arg         
            180                 185                 190                 

ttt gcc cgg aag ccc att tcc atc atc gac ctc atc gtg gtc gtg gcc      624
Phe Ala Arg Lys Pro Ile Ser Ile Ile Asp Leu Ile Val Val Val Ala         
        195                 200                 205                     

tcc atg gtg gtc ctc tgc gtg ggc tcc aag ggg cag gtg ttt gcc acg      672
Ser Met Val Val Leu Cys Val Gly Ser Lys Gly Gln Val Phe Ala Thr         
    210                 215                 220                         

tcg gcc atc agg ggc atc cgc ttc ctg cag atc ctg agg atg cta cac      720
Ser Ala Ile Arg Gly Ile Arg Phe Leu Gln Ile Leu Arg Met Leu His         
225                 230                 235                 240         

gtc gac cgc cag gga ggc acc tgg agg ctc ctg ggc tcc gtg gtc ttc      768
Val Asp Arg Gln Gly Gly Thr Trp Arg Leu Leu Gly Ser Val Val Phe         
                245                 250                 255             

atc cac cgc cag gag ctg ata acc acc ctg tac atc ggc ttc ctg ggc      816
Ile His Arg Gln Glu Leu Ile Thr Thr Leu Tyr Ile Gly Phe Leu Gly         
            260                 265                 270                 

ctc atc ttc tcc tcg tac ttt gtg tac ctg gct gag aag gac gcg gtg      864
Leu Ile Phe Ser Ser Tyr Phe Val Tyr Leu Ala Glu Lys Asp Ala Val         
        275                 280                 285                     

aac gag tca ggc cgc gtg gag ttc ggc agc tac gca gat gcg ctg tgg      912
Asn Glu Ser Gly Arg Val Glu Phe Gly Ser Tyr Ala Asp Ala Leu Trp         
    290                 295                 300                         

tgg ggg gtg gtc aca gtc acc acc atc ggc tat ggg gac aag gtg ccc      960
Trp Gly Val Val Thr Val Thr Thr Ile Gly Tyr Gly Asp Lys Val Pro         
305                 310                 315                 320         

cag acg tgg gtc ggg aag acc atc gcc tcc tgc ttc tct gtc ttt gcc     1008
Gln Thr Trp Val Gly Lys Thr Ile Ala Ser Cys Phe Ser Val Phe Ala         
                325                 330                 335             

atc tcc ttc ttt gcg ctc cca gcg ggg att ctt ggc tcg ggg ttt gcc     1056
Ile Ser Phe Phe Ala Leu Pro Ala Gly Ile Leu Gly Ser Gly Phe Ala         
            340                 345                 350                 

ctg aag gtg cag cag aag cag agg cag aag cac ttc aac cgg cag atc     1104
Leu Lys Val Gln Gln Lys Gln Arg Gln Lys His Phe Asn Arg Gln Ile         
        355                 360                 365                     

ccg gcg gca gcc tca ctc att cag acc gca tgg agg tgc tat gct gcc     1152
Pro Ala Ala Ala Ser Leu Ile Gln Thr Ala Trp Arg Cys Tyr Ala Ala         
    370                 375                 380                         

gag aac ccc gac tcc tcc acc tgg aag atc tac atc cgg aag gcc ccc     1200
Glu Asn Pro Asp Ser Ser Thr Trp Lys Ile Tyr Ile Arg Lys Ala Pro         
385                 390                 395                 400         

cgg agc cac act ctg ctg tca ccc agc ccc aaa ccc aag aag tct gtg     1248
Arg Ser His Thr Leu Leu Ser Pro Ser Pro Lys Pro Lys Lys Ser Val         
                405                 410                 415             

gtg gta aag aaa aaa aag ttc aag ctg gac aaa gac aat ggg gtg act     1296
Val Val Lys Lys Lys Lys Phe Lys Leu Asp Lys Asp Asn Gly Val Thr         
            420                 425                 430                 

cct gga gag aag atg ctc aca gtc ccc cat atc acg tgc gac ccc cca     1344
Pro Gly Glu Lys Met Leu Thr Val Pro His Ile Thr Cys Asp Pro Pro         
        435                 440                 445                     

gaa gag cgg cgg ctg gac cac ttc tct gtc gac ggc tat gac agt tct     1392
Glu Glu Arg Arg Leu Asp His Phe Ser Val Asp Gly Tyr Asp Ser Ser         
    450                 455                 460                         

gta agg aag agc cca aca ctg ctg gaa gtg agc atg ccc cat ttc atg     1440
Val Arg Lys Ser Pro Thr Leu Leu Glu Val Ser Met Pro His Phe Met         
465                 470                 475                 480         

aga acc aac agc ttc gcc gag gac ctg gac ctg gaa ggg gag act ctg     1488
Arg Thr Asn Ser Phe Ala Glu Asp Leu Asp Leu Glu Gly Glu Thr Leu         
                485                 490                 495             

ctg aca ccc atc acc cac atc tca cag ctg cgg gaa cac cat cgg gcc     1536
Leu Thr Pro Ile Thr His Ile Ser Gln Leu Arg Glu His His Arg Ala         
            500                 505                 510                 

acc att aag gtc att cga cgc atg cag tac ttt gtg gcc aag aag aaa     1584
Thr Ile Lys Val Ile Arg Arg Met Gln Tyr Phe Val Ala Lys Lys Lys         
        515                 520                 525                     

ttc cag caa gcg cgg aag cct tac gat gtg cgg gac gtc att gag cag     1632
Phe Gln Gln Ala Arg Lys Pro Tyr Asp Val Arg Asp Val Ile Glu Gln         
    530                 535                 540                         

tac tcg cag ggc cac ctc aac ctc atg gtg cgc atc aag gag ctg cag     1680
Tyr Ser Gln Gly His Leu Asn Leu Met Val Arg Ile Lys Glu Leu Gln         
545                 550                 555                 560         

agg agg ctg gac cag tcc att ggg aag ccc tca ctg ttc atc tcc gtc     1728
Arg Arg Leu Asp Gln Ser Ile Gly Lys Pro Ser Leu Phe Ile Ser Val         
                565                 570                 575             

tca gaa aag agc aag gat cgc ggc agc aac acg atc ggc gcc cgc ctg     1776
Ser Glu Lys Ser Lys Asp Arg Gly Ser Asn Thr Ile Gly Ala Arg Leu         
            580                 585                 590                 

aac cga gta gaa gac aag gtg acg cag ctg gac cag agg ctg gca ctc     1824
Asn Arg Val Glu Asp Lys Val Thr Gln Leu Asp Gln Arg Leu Ala Leu         
        595                 600                 605                     

atc acc gac atg ctt cac cag ctg ctc tcc ttg cac ggt ggc agc acc     1872
Ile Thr Asp Met Leu His Gln Leu Leu Ser Leu His Gly Gly Ser Thr         
    610                 615                 620                         

ccc ggc agc ggc ggc ccc ccc aga gag ggc ggg gcc cac atc acc cag     1920
Pro Gly Ser Gly Gly Pro Pro Arg Glu Gly Gly Ala His Ile Thr Gln         
625                 630                 635                 640         

ccc tgc ggc agt ggc ggc tcc gtc gac cct gag ctc ttc ctg ccc agc     1968
Pro Cys Gly Ser Gly Gly Ser Val Asp Pro Glu Leu Phe Leu Pro Ser         
                645                 650                 655             

aac acc ctg ccc acc tac gag cag ctg acc gtg ccc agg agg ggc ccc     2016
Asn Thr Leu Pro Thr Tyr Glu Gln Leu Thr Val Pro Arg Arg Gly Pro         
            660                 665                 670                 

gat gag ggg tcc tga                                                 2031
Asp Glu Gly Ser                                                         
        675                                                             


<210>  2
<211>  676
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Ala Ala Ser Ser Pro Pro Arg Ala Glu Arg Lys Arg Trp Gly 
1               5                   10                  15      


Trp Gly Arg Leu Pro Gly Ala Arg Arg Gly Ser Ala Gly Leu Ala Lys 
            20                  25                  30          


Lys Cys Pro Phe Ser Leu Glu Leu Ala Glu Gly Gly Pro Ala Gly Gly 
        35                  40                  45              


Ala Leu Tyr Ala Pro Ile Ala Pro Gly Ala Pro Gly Pro Ala Pro Pro 
    50                  55                  60                  


Ala Ser Pro Ala Ala Pro Ala Ala Pro Pro Val Ala Ser Asp Leu Gly 
65                  70                  75                  80  


Pro Arg Pro Pro Val Ser Leu Asp Pro Arg Val Ser Ile Tyr Ser Thr 
                85                  90                  95      


Arg Arg Pro Val Leu Ala Arg Thr His Val Gln Gly Arg Val Tyr Asn 
            100                 105                 110         


Phe Leu Glu Arg Pro Thr Gly Trp Lys Cys Phe Val Tyr His Phe Ala 
        115                 120                 125             


Val Phe Leu Ile Val Leu Val Cys Leu Ile Phe Ser Val Leu Ser Thr 
    130                 135                 140                 


Ile Glu Gln Tyr Ala Ala Leu Ala Thr Gly Thr Leu Phe Trp Met Glu 
145                 150                 155                 160 


Ile Val Leu Val Val Phe Phe Gly Thr Glu Tyr Val Val Arg Leu Trp 
                165                 170                 175     


Ser Ala Gly Cys Arg Ser Lys Tyr Val Gly Leu Trp Gly Arg Leu Arg 
            180                 185                 190         


Phe Ala Arg Lys Pro Ile Ser Ile Ile Asp Leu Ile Val Val Val Ala 
        195                 200                 205             


Ser Met Val Val Leu Cys Val Gly Ser Lys Gly Gln Val Phe Ala Thr 
    210                 215                 220                 


Ser Ala Ile Arg Gly Ile Arg Phe Leu Gln Ile Leu Arg Met Leu His 
225                 230                 235                 240 


Val Asp Arg Gln Gly Gly Thr Trp Arg Leu Leu Gly Ser Val Val Phe 
                245                 250                 255     


Ile His Arg Gln Glu Leu Ile Thr Thr Leu Tyr Ile Gly Phe Leu Gly 
            260                 265                 270         


Leu Ile Phe Ser Ser Tyr Phe Val Tyr Leu Ala Glu Lys Asp Ala Val 
        275                 280                 285             


Asn Glu Ser Gly Arg Val Glu Phe Gly Ser Tyr Ala Asp Ala Leu Trp 
    290                 295                 300                 


Trp Gly Val Val Thr Val Thr Thr Ile Gly Tyr Gly Asp Lys Val Pro 
305                 310                 315                 320 


Gln Thr Trp Val Gly Lys Thr Ile Ala Ser Cys Phe Ser Val Phe Ala 
                325                 330                 335     


Ile Ser Phe Phe Ala Leu Pro Ala Gly Ile Leu Gly Ser Gly Phe Ala 
            340                 345                 350         


Leu Lys Val Gln Gln Lys Gln Arg Gln Lys His Phe Asn Arg Gln Ile 
        355                 360                 365             


Pro Ala Ala Ala Ser Leu Ile Gln Thr Ala Trp Arg Cys Tyr Ala Ala 
    370                 375                 380                 


Glu Asn Pro Asp Ser Ser Thr Trp Lys Ile Tyr Ile Arg Lys Ala Pro 
385                 390                 395                 400 


Arg Ser His Thr Leu Leu Ser Pro Ser Pro Lys Pro Lys Lys Ser Val 
                405                 410                 415     


Val Val Lys Lys Lys Lys Phe Lys Leu Asp Lys Asp Asn Gly Val Thr 
            420                 425                 430         


Pro Gly Glu Lys Met Leu Thr Val Pro His Ile Thr Cys Asp Pro Pro 
        435                 440                 445             


Glu Glu Arg Arg Leu Asp His Phe Ser Val Asp Gly Tyr Asp Ser Ser 
    450                 455                 460                 


Val Arg Lys Ser Pro Thr Leu Leu Glu Val Ser Met Pro His Phe Met 
465                 470                 475                 480 


Arg Thr Asn Ser Phe Ala Glu Asp Leu Asp Leu Glu Gly Glu Thr Leu 
                485                 490                 495     


Leu Thr Pro Ile Thr His Ile Ser Gln Leu Arg Glu His His Arg Ala 
            500                 505                 510         


Thr Ile Lys Val Ile Arg Arg Met Gln Tyr Phe Val Ala Lys Lys Lys 
        515                 520                 525             


Phe Gln Gln Ala Arg Lys Pro Tyr Asp Val Arg Asp Val Ile Glu Gln 
    530                 535                 540                 


Tyr Ser Gln Gly His Leu Asn Leu Met Val Arg Ile Lys Glu Leu Gln 
545                 550                 555                 560 


Arg Arg Leu Asp Gln Ser Ile Gly Lys Pro Ser Leu Phe Ile Ser Val 
                565                 570                 575     


Ser Glu Lys Ser Lys Asp Arg Gly Ser Asn Thr Ile Gly Ala Arg Leu 
            580                 585                 590         


Asn Arg Val Glu Asp Lys Val Thr Gln Leu Asp Gln Arg Leu Ala Leu 
        595                 600                 605             


Ile Thr Asp Met Leu His Gln Leu Leu Ser Leu His Gly Gly Ser Thr 
    610                 615                 620                 


Pro Gly Ser Gly Gly Pro Pro Arg Glu Gly Gly Ala His Ile Thr Gln 
625                 630                 635                 640 


Pro Cys Gly Ser Gly Gly Ser Val Asp Pro Glu Leu Phe Leu Pro Ser 
                645                 650                 655     


Asn Thr Leu Pro Thr Tyr Glu Gln Leu Thr Val Pro Arg Arg Gly Pro 
            660                 665                 670         


Asp Glu Gly Ser 
        675     


<210>  3
<211>  3480
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(3480)
<223>  KCNH2 cDNA (GenBank Acc. N NM000238): nucleotides 14 to 3493

<400>  3
atg ccg gtg cgg agg ggc cac gtc gcg ccg cag aac acc ttc ctg gac       48
Met Pro Val Arg Arg Gly His Val Ala Pro Gln Asn Thr Phe Leu Asp         
1               5                   10                  15              

acc atc atc cgc aag ttt gag ggc cag agc cgt aag ttc atc atc gcc       96
Thr Ile Ile Arg Lys Phe Glu Gly Gln Ser Arg Lys Phe Ile Ile Ala         
            20                  25                  30                  

aac gct cgg gtg gag aac tgc gcc gtc atc tac tgc aac gac ggc ttc      144
Asn Ala Arg Val Glu Asn Cys Ala Val Ile Tyr Cys Asn Asp Gly Phe         
        35                  40                  45                      

tgc gag ctg tgc ggc tac tcg cgg gcc gag gtg atg cag cga ccc tgc      192
Cys Glu Leu Cys Gly Tyr Ser Arg Ala Glu Val Met Gln Arg Pro Cys         
    50                  55                  60                          

acc tgc gac ttc ctg cac ggg ccg cgc acg cag cgc cgc gct gcc gcg      240
Thr Cys Asp Phe Leu His Gly Pro Arg Thr Gln Arg Arg Ala Ala Ala         
65                  70                  75                  80          

cag atc gcg cag gca ctg ctg ggc gcc gag gag cgc aaa gtg gaa atc      288
Gln Ile Ala Gln Ala Leu Leu Gly Ala Glu Glu Arg Lys Val Glu Ile         
                85                  90                  95              

gcc ttc tac cgg aaa gat ggg agc tgc ttc cta tgt ctg gtg gat gtg      336
Ala Phe Tyr Arg Lys Asp Gly Ser Cys Phe Leu Cys Leu Val Asp Val         
            100                 105                 110                 

gtg ccc gtg aag aac gag gat ggg gct gtc atc atg ttc atc ctc aat      384
Val Pro Val Lys Asn Glu Asp Gly Ala Val Ile Met Phe Ile Leu Asn         
        115                 120                 125                     

ttc gag gtg gtg atg gag aag gac atg gtg ggg tcc ccg gct cat gac      432
Phe Glu Val Val Met Glu Lys Asp Met Val Gly Ser Pro Ala His Asp         
    130                 135                 140                         

acc aac cac cgg ggc ccc ccc acc agc tgg ctg gcc cca ggc cgc gcc      480
Thr Asn His Arg Gly Pro Pro Thr Ser Trp Leu Ala Pro Gly Arg Ala         
145                 150                 155                 160         

aag acc ttc cgc ctg aag ctg ccc gcg ctg ctg gcg ctg acg gcc cgg      528
Lys Thr Phe Arg Leu Lys Leu Pro Ala Leu Leu Ala Leu Thr Ala Arg         
                165                 170                 175             

gag tcg tcg gtg cgg tcg ggc ggc gcg ggc ggc gcg ggc gcc ccg ggg      576
Glu Ser Ser Val Arg Ser Gly Gly Ala Gly Gly Ala Gly Ala Pro Gly         
            180                 185                 190                 

gcc gtg gtg gtg gac gtg gac ctg acg ccc gcg gca ccc agc agc gag      624
Ala Val Val Val Asp Val Asp Leu Thr Pro Ala Ala Pro Ser Ser Glu         
        195                 200                 205                     

tcg ctg gcc ctg gac gaa gtg aca gcc atg gac aac cac gtg gca ggg      672
Ser Leu Ala Leu Asp Glu Val Thr Ala Met Asp Asn His Val Ala Gly         
    210                 215                 220                         

ctc ggg ccc gcg gag gag cgg cgt gcg ctg gtg ggt ccc ggc tct ccg      720
Leu Gly Pro Ala Glu Glu Arg Arg Ala Leu Val Gly Pro Gly Ser Pro         
225                 230                 235                 240         

ccc cgc agc gcg ccc ggc cag ctc cca tcg ccc cgg gcg cac agc ctc      768
Pro Arg Ser Ala Pro Gly Gln Leu Pro Ser Pro Arg Ala His Ser Leu         
                245                 250                 255             

aac ccc gac gcc tcg ggc tcc agc tgc agc ctg gcc cgg acg cgc tcc      816
Asn Pro Asp Ala Ser Gly Ser Ser Cys Ser Leu Ala Arg Thr Arg Ser         
            260                 265                 270                 

cga gaa agc tgc gcc agc gtg cgc cgc gcc tcg tcg gcc gac gac atc      864
Arg Glu Ser Cys Ala Ser Val Arg Arg Ala Ser Ser Ala Asp Asp Ile         
        275                 280                 285                     

gag gcc atg cgc gcc ggg gtg ctg ccc ccg cca ccg cgc cac gcc agc      912
Glu Ala Met Arg Ala Gly Val Leu Pro Pro Pro Pro Arg His Ala Ser         
    290                 295                 300                         

acc ggg gcc atg cac cca ctg cgc agc ggc ttg ctc aac tcc acc tcg      960
Thr Gly Ala Met His Pro Leu Arg Ser Gly Leu Leu Asn Ser Thr Ser         
305                 310                 315                 320         

gac tcc gac ctc gtg cgc tac cgc acc att agc aag att ccc caa atc     1008
Asp Ser Asp Leu Val Arg Tyr Arg Thr Ile Ser Lys Ile Pro Gln Ile         
                325                 330                 335             

acc ctc aac ttt gtg gac ctc aag ggc gac ccc ttc ttg gct tcg ccc     1056
Thr Leu Asn Phe Val Asp Leu Lys Gly Asp Pro Phe Leu Ala Ser Pro         
            340                 345                 350                 

acc agt gac cgt gag atc ata gca cct aag ata aag gag cga acc cac     1104
Thr Ser Asp Arg Glu Ile Ile Ala Pro Lys Ile Lys Glu Arg Thr His         
        355                 360                 365                     

aat gtc act gag aag gtc acc cag gtc ctg tcc ctg ggc gcc gac gtg     1152
Asn Val Thr Glu Lys Val Thr Gln Val Leu Ser Leu Gly Ala Asp Val         
    370                 375                 380                         

ctg cct gag tac aag ctg cag gca ccg cgc atc cac cgc tgg acc atc     1200
Leu Pro Glu Tyr Lys Leu Gln Ala Pro Arg Ile His Arg Trp Thr Ile         
385                 390                 395                 400         

ctg cat tac agc ccc ttc aag gcc gtg tgg gac tgg ctc atc ctg ctg     1248
Leu His Tyr Ser Pro Phe Lys Ala Val Trp Asp Trp Leu Ile Leu Leu         
                405                 410                 415             

ctg gtc atc tac acg gct gtc ttc aca ccc tac tcg gct gcc ttc ctg     1296
Leu Val Ile Tyr Thr Ala Val Phe Thr Pro Tyr Ser Ala Ala Phe Leu         
            420                 425                 430                 

ctg aag gag acg gaa gaa ggc ccg cct gct acc gag tgt ggc tac gcc     1344
Leu Lys Glu Thr Glu Glu Gly Pro Pro Ala Thr Glu Cys Gly Tyr Ala         
        435                 440                 445                     

tgc cag ccg ctg gct gtg gtg gac ctc atc gtg gac atc atg ttc att     1392
Cys Gln Pro Leu Ala Val Val Asp Leu Ile Val Asp Ile Met Phe Ile         
    450                 455                 460                         

gtg gac atc ctc atc aac ttc cgc acc acc tac gtc aat gcc aac gag     1440
Val Asp Ile Leu Ile Asn Phe Arg Thr Thr Tyr Val Asn Ala Asn Glu         
465                 470                 475                 480         

gag gtg gtc agc cac ccc ggc cgc atc gcc gtc cac tac ttc aag ggc     1488
Glu Val Val Ser His Pro Gly Arg Ile Ala Val His Tyr Phe Lys Gly         
                485                 490                 495             

tgg ttc ctc atc gac atg gtg gcc gcc atc ccc ttc gac ctg ctc atc     1536
Trp Phe Leu Ile Asp Met Val Ala Ala Ile Pro Phe Asp Leu Leu Ile         
            500                 505                 510                 

ttc ggc tct ggc tct gag gag ctg atc ggg ctg ctg aag act gcg cgg     1584
Phe Gly Ser Gly Ser Glu Glu Leu Ile Gly Leu Leu Lys Thr Ala Arg         
        515                 520                 525                     

ctg ctg cgg ctg gtg cgc gtg gcg cgg aag ctg gat cgc tac tca gag     1632
Leu Leu Arg Leu Val Arg Val Ala Arg Lys Leu Asp Arg Tyr Ser Glu         
    530                 535                 540                         

tac ggc gcg gcc gtg ctg ttc ttg ctc atg tgc acc ttt gcg ctc atc     1680
Tyr Gly Ala Ala Val Leu Phe Leu Leu Met Cys Thr Phe Ala Leu Ile         
545                 550                 555                 560         

gcg cac tgg cta gcc tgc atc tgg tac gcc atc ggc aac atg gag cag     1728
Ala His Trp Leu Ala Cys Ile Trp Tyr Ala Ile Gly Asn Met Glu Gln         
                565                 570                 575             

cca cac atg gac tca cgc atc ggc tgg ctg cac aac ctg ggc gac cag     1776
Pro His Met Asp Ser Arg Ile Gly Trp Leu His Asn Leu Gly Asp Gln         
            580                 585                 590                 

ata ggc aaa ccc tac aac agc agc ggc ctg ggc ggc ccc tcc atc aag     1824
Ile Gly Lys Pro Tyr Asn Ser Ser Gly Leu Gly Gly Pro Ser Ile Lys         
        595                 600                 605                     

gac aag tat gtg acg gcg ctc tac ttc acc ttc agc agc ctc acc agt     1872
Asp Lys Tyr Val Thr Ala Leu Tyr Phe Thr Phe Ser Ser Leu Thr Ser         
    610                 615                 620                         

gtg ggc ttc ggc aac gtc tct ccc aac acc aac tca gag aag atc ttc     1920
Val Gly Phe Gly Asn Val Ser Pro Asn Thr Asn Ser Glu Lys Ile Phe         
625                 630                 635                 640         

tcc atc tgc gtc atg ctc att ggc tcc ctc atg tat gct agc atc ttc     1968
Ser Ile Cys Val Met Leu Ile Gly Ser Leu Met Tyr Ala Ser Ile Phe         
                645                 650                 655             

ggc aac gtg tcg gcc atc atc cag cgg ctg tac tcg ggc aca gcc cgc     2016
Gly Asn Val Ser Ala Ile Ile Gln Arg Leu Tyr Ser Gly Thr Ala Arg         
            660                 665                 670                 

tac cac aca cag atg ctg cgg gtg cgg gag ttc atc cgc ttc cac cag     2064
Tyr His Thr Gln Met Leu Arg Val Arg Glu Phe Ile Arg Phe His Gln         
        675                 680                 685                     

atc ccc aat ccc ctg cgc cag cgc ctc gag gag tac ttc cag cac gcc     2112
Ile Pro Asn Pro Leu Arg Gln Arg Leu Glu Glu Tyr Phe Gln His Ala         
    690                 695                 700                         

tgg tcc tac acc aac ggc atc gac atg aac gcg gtg ctg aag ggc ttc     2160
Trp Ser Tyr Thr Asn Gly Ile Asp Met Asn Ala Val Leu Lys Gly Phe         
705                 710                 715                 720         

cct gag tgc ctg cag gct gac atc tgc ctg cac ctg aac cgc tca ctg     2208
Pro Glu Cys Leu Gln Ala Asp Ile Cys Leu His Leu Asn Arg Ser Leu         
                725                 730                 735             

ctg cag cac tgc aaa ccc ttc cga ggg gcc acc aag ggc tgc ctt cgg     2256
Leu Gln His Cys Lys Pro Phe Arg Gly Ala Thr Lys Gly Cys Leu Arg         
            740                 745                 750                 

gcc ctg gcc atg aag ttc aag acc aca cat gca ccg cca ggg gac aca     2304
Ala Leu Ala Met Lys Phe Lys Thr Thr His Ala Pro Pro Gly Asp Thr         
        755                 760                 765                     

ctg gtg cat gct ggg gac ctg ctc acc gcc ctg tac ttc atc tcc cgg     2352
Leu Val His Ala Gly Asp Leu Leu Thr Ala Leu Tyr Phe Ile Ser Arg         
    770                 775                 780                         

ggc tcc atc gag atc ctg cgg ggc gac gtc gtc gtg gcc atc ctg ggg     2400
Gly Ser Ile Glu Ile Leu Arg Gly Asp Val Val Val Ala Ile Leu Gly         
785                 790                 795                 800         

aag aat gac atc ttt ggg gag cct ctg aac ctg tat gca agg cct ggc     2448
Lys Asn Asp Ile Phe Gly Glu Pro Leu Asn Leu Tyr Ala Arg Pro Gly         
                805                 810                 815             

aag tcg aac ggg gat gtg cgg gcc ctc acc tac tgt gac cta cac aag     2496
Lys Ser Asn Gly Asp Val Arg Ala Leu Thr Tyr Cys Asp Leu His Lys         
            820                 825                 830                 

atc cat cgg gac gac ctg ctg gag gtg ctg gac atg tac cct gag ttc     2544
Ile His Arg Asp Asp Leu Leu Glu Val Leu Asp Met Tyr Pro Glu Phe         
        835                 840                 845                     

tcc gac cac ttc tgg tcc agc ctg gag atc acc ttc aac ctg cga gat     2592
Ser Asp His Phe Trp Ser Ser Leu Glu Ile Thr Phe Asn Leu Arg Asp         
    850                 855                 860                         

acc aac atg atc ccg ggc tcc ccc ggc agt acg gag tta gag ggt ggc     2640
Thr Asn Met Ile Pro Gly Ser Pro Gly Ser Thr Glu Leu Glu Gly Gly         
865                 870                 875                 880         

ttc agt cgg caa cgc aag cgc aag ttg tcc ttc cgc agg cgc acg gac     2688
Phe Ser Arg Gln Arg Lys Arg Lys Leu Ser Phe Arg Arg Arg Thr Asp         
                885                 890                 895             

aag gac acg gag cag cca ggg gag gtg tcg gcc ttg ggg ccg ggc cgg     2736
Lys Asp Thr Glu Gln Pro Gly Glu Val Ser Ala Leu Gly Pro Gly Arg         
            900                 905                 910                 

gcg ggg gca ggg ccg agt agc cgg ggc cgg ccg ggg ggg ccg tgg ggg     2784
Ala Gly Ala Gly Pro Ser Ser Arg Gly Arg Pro Gly Gly Pro Trp Gly         
        915                 920                 925                     

gag agc ccg tcc agt ggc ccc tcc agc cct gag agc agt gag gat gag     2832
Glu Ser Pro Ser Ser Gly Pro Ser Ser Pro Glu Ser Ser Glu Asp Glu         
    930                 935                 940                         

ggc cca ggc cgc agc tcc agc ccc ctc cgc ctg gtg ccc ttc tcc agc     2880
Gly Pro Gly Arg Ser Ser Ser Pro Leu Arg Leu Val Pro Phe Ser Ser         
945                 950                 955                 960         

ccc agg ccc ccc gga gag ccg ccg ggt ggg gag ccc ctg atg gag gac     2928
Pro Arg Pro Pro Gly Glu Pro Pro Gly Gly Glu Pro Leu Met Glu Asp         
                965                 970                 975             

tgc gag aag agc agc gac act tgc aac ccc ctg tca ggc gcc ttc tca     2976
Cys Glu Lys Ser Ser Asp Thr Cys Asn Pro Leu Ser Gly Ala Phe Ser         
            980                 985                 990                 

gga gtg tcc aac att ttc agc ttc  tgg ggg gac agt cgg  ggc cgc cag   3024
Gly Val Ser Asn Ile Phe Ser Phe  Trp Gly Asp Ser Arg  Gly Arg Gln       
        995                 1000                 1005                   

tac cag  gag ctc cct cga tgc  ccc gcc ccc acc ccc  agc ctc ctc      3069
Tyr Gln  Glu Leu Pro Arg Cys  Pro Ala Pro Thr Pro  Ser Leu Leu          
    1010                 1015                 1020                      

aac atc  ccc ctc tcc agc ccg  ggt cgg cgg ccc cgg  ggc gac gtg      3114
Asn Ile  Pro Leu Ser Ser Pro  Gly Arg Arg Pro Arg  Gly Asp Val          
    1025                 1030                 1035                      

gag agc  agg ctg gat gcc ctc  cag cgc cag ctc aac  agg ctg gag      3159
Glu Ser  Arg Leu Asp Ala Leu  Gln Arg Gln Leu Asn  Arg Leu Glu          
    1040                 1045                 1050                      

acc cgg  ctg agt gca gac atg  gcc act gtc ctg cag  ctg cta cag      3204
Thr Arg  Leu Ser Ala Asp Met  Ala Thr Val Leu Gln  Leu Leu Gln          
    1055                 1060                 1065                      

agg cag  atg acg ctg gtc ccg  ccc gcc tac agt gct  gtg acc acc      3249
Arg Gln  Met Thr Leu Val Pro  Pro Ala Tyr Ser Ala  Val Thr Thr          
    1070                 1075                 1080                      

ccg ggg  cct ggc ccc act tcc  aca tcc ccg ctg ttg  ccc gtc agc      3294
Pro Gly  Pro Gly Pro Thr Ser  Thr Ser Pro Leu Leu  Pro Val Ser          
    1085                 1090                 1095                      

ccc ctc  ccc acc ctc acc ttg  gac tcg ctt tct cag  gtt tcc cag      3339
Pro Leu  Pro Thr Leu Thr Leu  Asp Ser Leu Ser Gln  Val Ser Gln          
    1100                 1105                 1110                      

ttc atg  gcg tgt gag gag ctg  ccc ccg ggg gcc cca  gag ctt ccc      3384
Phe Met  Ala Cys Glu Glu Leu  Pro Pro Gly Ala Pro  Glu Leu Pro          
    1115                 1120                 1125                      

caa gaa  ggc ccc aca cga cgc  ctc tcc cta ccg ggc  cag ctg ggg      3429
Gln Glu  Gly Pro Thr Arg Arg  Leu Ser Leu Pro Gly  Gln Leu Gly          
    1130                 1135                 1140                      

gcc ctc  acc tcc cag ccc ctg  cac aga cac ggc tcg  gac ccg ggc      3474
Ala Leu  Thr Ser Gln Pro Leu  His Arg His Gly Ser  Asp Pro Gly          
    1145                 1150                 1155                      

agt tag                                                             3480
Ser                                                                     
                                                                        


<210>  4
<211>  1159
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Pro Val Arg Arg Gly His Val Ala Pro Gln Asn Thr Phe Leu Asp 
1               5                   10                  15      


Thr Ile Ile Arg Lys Phe Glu Gly Gln Ser Arg Lys Phe Ile Ile Ala 
            20                  25                  30          


Asn Ala Arg Val Glu Asn Cys Ala Val Ile Tyr Cys Asn Asp Gly Phe 
        35                  40                  45              


Cys Glu Leu Cys Gly Tyr Ser Arg Ala Glu Val Met Gln Arg Pro Cys 
    50                  55                  60                  


Thr Cys Asp Phe Leu His Gly Pro Arg Thr Gln Arg Arg Ala Ala Ala 
65                  70                  75                  80  


Gln Ile Ala Gln Ala Leu Leu Gly Ala Glu Glu Arg Lys Val Glu Ile 
                85                  90                  95      


Ala Phe Tyr Arg Lys Asp Gly Ser Cys Phe Leu Cys Leu Val Asp Val 
            100                 105                 110         


Val Pro Val Lys Asn Glu Asp Gly Ala Val Ile Met Phe Ile Leu Asn 
        115                 120                 125             


Phe Glu Val Val Met Glu Lys Asp Met Val Gly Ser Pro Ala His Asp 
    130                 135                 140                 


Thr Asn His Arg Gly Pro Pro Thr Ser Trp Leu Ala Pro Gly Arg Ala 
145                 150                 155                 160 


Lys Thr Phe Arg Leu Lys Leu Pro Ala Leu Leu Ala Leu Thr Ala Arg 
                165                 170                 175     


Glu Ser Ser Val Arg Ser Gly Gly Ala Gly Gly Ala Gly Ala Pro Gly 
            180                 185                 190         


Ala Val Val Val Asp Val Asp Leu Thr Pro Ala Ala Pro Ser Ser Glu 
        195                 200                 205             


Ser Leu Ala Leu Asp Glu Val Thr Ala Met Asp Asn His Val Ala Gly 
    210                 215                 220                 


Leu Gly Pro Ala Glu Glu Arg Arg Ala Leu Val Gly Pro Gly Ser Pro 
225                 230                 235                 240 


Pro Arg Ser Ala Pro Gly Gln Leu Pro Ser Pro Arg Ala His Ser Leu 
                245                 250                 255     


Asn Pro Asp Ala Ser Gly Ser Ser Cys Ser Leu Ala Arg Thr Arg Ser 
            260                 265                 270         


Arg Glu Ser Cys Ala Ser Val Arg Arg Ala Ser Ser Ala Asp Asp Ile 
        275                 280                 285             


Glu Ala Met Arg Ala Gly Val Leu Pro Pro Pro Pro Arg His Ala Ser 
    290                 295                 300                 


Thr Gly Ala Met His Pro Leu Arg Ser Gly Leu Leu Asn Ser Thr Ser 
305                 310                 315                 320 


Asp Ser Asp Leu Val Arg Tyr Arg Thr Ile Ser Lys Ile Pro Gln Ile 
                325                 330                 335     


Thr Leu Asn Phe Val Asp Leu Lys Gly Asp Pro Phe Leu Ala Ser Pro 
            340                 345                 350         


Thr Ser Asp Arg Glu Ile Ile Ala Pro Lys Ile Lys Glu Arg Thr His 
        355                 360                 365             


Asn Val Thr Glu Lys Val Thr Gln Val Leu Ser Leu Gly Ala Asp Val 
    370                 375                 380                 


Leu Pro Glu Tyr Lys Leu Gln Ala Pro Arg Ile His Arg Trp Thr Ile 
385                 390                 395                 400 


Leu His Tyr Ser Pro Phe Lys Ala Val Trp Asp Trp Leu Ile Leu Leu 
                405                 410                 415     


Leu Val Ile Tyr Thr Ala Val Phe Thr Pro Tyr Ser Ala Ala Phe Leu 
            420                 425                 430         


Leu Lys Glu Thr Glu Glu Gly Pro Pro Ala Thr Glu Cys Gly Tyr Ala 
        435                 440                 445             


Cys Gln Pro Leu Ala Val Val Asp Leu Ile Val Asp Ile Met Phe Ile 
    450                 455                 460                 


Val Asp Ile Leu Ile Asn Phe Arg Thr Thr Tyr Val Asn Ala Asn Glu 
465                 470                 475                 480 


Glu Val Val Ser His Pro Gly Arg Ile Ala Val His Tyr Phe Lys Gly 
                485                 490                 495     


Trp Phe Leu Ile Asp Met Val Ala Ala Ile Pro Phe Asp Leu Leu Ile 
            500                 505                 510         


Phe Gly Ser Gly Ser Glu Glu Leu Ile Gly Leu Leu Lys Thr Ala Arg 
        515                 520                 525             


Leu Leu Arg Leu Val Arg Val Ala Arg Lys Leu Asp Arg Tyr Ser Glu 
    530                 535                 540                 


Tyr Gly Ala Ala Val Leu Phe Leu Leu Met Cys Thr Phe Ala Leu Ile 
545                 550                 555                 560 


Ala His Trp Leu Ala Cys Ile Trp Tyr Ala Ile Gly Asn Met Glu Gln 
                565                 570                 575     


Pro His Met Asp Ser Arg Ile Gly Trp Leu His Asn Leu Gly Asp Gln 
            580                 585                 590         


Ile Gly Lys Pro Tyr Asn Ser Ser Gly Leu Gly Gly Pro Ser Ile Lys 
        595                 600                 605             


Asp Lys Tyr Val Thr Ala Leu Tyr Phe Thr Phe Ser Ser Leu Thr Ser 
    610                 615                 620                 


Val Gly Phe Gly Asn Val Ser Pro Asn Thr Asn Ser Glu Lys Ile Phe 
625                 630                 635                 640 


Ser Ile Cys Val Met Leu Ile Gly Ser Leu Met Tyr Ala Ser Ile Phe 
                645                 650                 655     


Gly Asn Val Ser Ala Ile Ile Gln Arg Leu Tyr Ser Gly Thr Ala Arg 
            660                 665                 670         


Tyr His Thr Gln Met Leu Arg Val Arg Glu Phe Ile Arg Phe His Gln 
        675                 680                 685             


Ile Pro Asn Pro Leu Arg Gln Arg Leu Glu Glu Tyr Phe Gln His Ala 
    690                 695                 700                 


Trp Ser Tyr Thr Asn Gly Ile Asp Met Asn Ala Val Leu Lys Gly Phe 
705                 710                 715                 720 


Pro Glu Cys Leu Gln Ala Asp Ile Cys Leu His Leu Asn Arg Ser Leu 
                725                 730                 735     


Leu Gln His Cys Lys Pro Phe Arg Gly Ala Thr Lys Gly Cys Leu Arg 
            740                 745                 750         


Ala Leu Ala Met Lys Phe Lys Thr Thr His Ala Pro Pro Gly Asp Thr 
        755                 760                 765             


Leu Val His Ala Gly Asp Leu Leu Thr Ala Leu Tyr Phe Ile Ser Arg 
    770                 775                 780                 


Gly Ser Ile Glu Ile Leu Arg Gly Asp Val Val Val Ala Ile Leu Gly 
785                 790                 795                 800 


Lys Asn Asp Ile Phe Gly Glu Pro Leu Asn Leu Tyr Ala Arg Pro Gly 
                805                 810                 815     


Lys Ser Asn Gly Asp Val Arg Ala Leu Thr Tyr Cys Asp Leu His Lys 
            820                 825                 830         


Ile His Arg Asp Asp Leu Leu Glu Val Leu Asp Met Tyr Pro Glu Phe 
        835                 840                 845             


Ser Asp His Phe Trp Ser Ser Leu Glu Ile Thr Phe Asn Leu Arg Asp 
    850                 855                 860                 


Thr Asn Met Ile Pro Gly Ser Pro Gly Ser Thr Glu Leu Glu Gly Gly 
865                 870                 875                 880 


Phe Ser Arg Gln Arg Lys Arg Lys Leu Ser Phe Arg Arg Arg Thr Asp 
                885                 890                 895     


Lys Asp Thr Glu Gln Pro Gly Glu Val Ser Ala Leu Gly Pro Gly Arg 
            900                 905                 910         


Ala Gly Ala Gly Pro Ser Ser Arg Gly Arg Pro Gly Gly Pro Trp Gly 
        915                 920                 925             


Glu Ser Pro Ser Ser Gly Pro Ser Ser Pro Glu Ser Ser Glu Asp Glu 
    930                 935                 940                 


Gly Pro Gly Arg Ser Ser Ser Pro Leu Arg Leu Val Pro Phe Ser Ser 
945                 950                 955                 960 


Pro Arg Pro Pro Gly Glu Pro Pro Gly Gly Glu Pro Leu Met Glu Asp 
                965                 970                 975     


Cys Glu Lys Ser Ser Asp Thr Cys Asn Pro Leu Ser Gly Ala Phe Ser 
            980                 985                 990         


Gly Val Ser Asn Ile Phe Ser Phe  Trp Gly Asp Ser Arg  Gly Arg Gln 
        995                 1000                 1005             


Tyr Gln  Glu Leu Pro Arg Cys  Pro Ala Pro Thr Pro  Ser Leu Leu 
    1010                 1015                 1020             


Asn Ile  Pro Leu Ser Ser Pro  Gly Arg Arg Pro Arg  Gly Asp Val 
    1025                 1030                 1035             


Glu Ser  Arg Leu Asp Ala Leu  Gln Arg Gln Leu Asn  Arg Leu Glu 
    1040                 1045                 1050             


Thr Arg  Leu Ser Ala Asp Met  Ala Thr Val Leu Gln  Leu Leu Gln 
    1055                 1060                 1065             


Arg Gln  Met Thr Leu Val Pro  Pro Ala Tyr Ser Ala  Val Thr Thr 
    1070                 1075                 1080             


Pro Gly  Pro Gly Pro Thr Ser  Thr Ser Pro Leu Leu  Pro Val Ser 
    1085                 1090                 1095             


Pro Leu  Pro Thr Leu Thr Leu  Asp Ser Leu Ser Gln  Val Ser Gln 
    1100                 1105                 1110             


Phe Met  Ala Cys Glu Glu Leu  Pro Pro Gly Ala Pro  Glu Leu Pro 
    1115                 1120                 1125             


Gln Glu  Gly Pro Thr Arg Arg  Leu Ser Leu Pro Gly  Gln Leu Gly 
    1130                 1135                 1140             


Ala Leu  Thr Ser Gln Pro Leu  His Arg His Gly Ser  Asp Pro Gly 
    1145                 1150                 1155             


Ser 
    


<210>  5
<211>  6051
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(6051)
<223>  SCN5A cDNA (GenBank Acc. N NM000335): nucleotides 151 to 6201

<400>  5
atg gca aac ttc cta tta cct cgg ggc acc agc agc ttc cgc agg ttc       48
Met Ala Asn Phe Leu Leu Pro Arg Gly Thr Ser Ser Phe Arg Arg Phe         
1               5                   10                  15              

aca cgg gag tcc ctg gca gcc atc gag aag cgc atg gcg gag aag caa       96
Thr Arg Glu Ser Leu Ala Ala Ile Glu Lys Arg Met Ala Glu Lys Gln         
            20                  25                  30                  

gcc cgc ggc tca acc acc ttg cag gag agc cga gag ggg ctg ccc gag      144
Ala Arg Gly Ser Thr Thr Leu Gln Glu Ser Arg Glu Gly Leu Pro Glu         
        35                  40                  45                      

gag gag gct ccc cgg ccc cag ctg gac ctg cag gcc tcc aaa aag ctg      192
Glu Glu Ala Pro Arg Pro Gln Leu Asp Leu Gln Ala Ser Lys Lys Leu         
    50                  55                  60                          

cca gat ctc tat ggc aat cca ccc caa gag ctc atc gga gag ccc ctg      240
Pro Asp Leu Tyr Gly Asn Pro Pro Gln Glu Leu Ile Gly Glu Pro Leu         
65                  70                  75                  80          

gag gac ctg gac ccc ttc tat agc acc caa aag act ttc atc gta ctg      288
Glu Asp Leu Asp Pro Phe Tyr Ser Thr Gln Lys Thr Phe Ile Val Leu         
                85                  90                  95              

aat aaa ggc aag acc atc ttc cgg ttc agt gcc acc aac gcc ttg tat      336
Asn Lys Gly Lys Thr Ile Phe Arg Phe Ser Ala Thr Asn Ala Leu Tyr         
            100                 105                 110                 

gtc ctc agt ccc ttc cac cca gtt cgg aga gcg gct gtg aag att ctg      384
Val Leu Ser Pro Phe His Pro Val Arg Arg Ala Ala Val Lys Ile Leu         
        115                 120                 125                     

gtt cac tcg ctc ttc aac atg ctc atc atg tgc acc atc ctc acc aac      432
Val His Ser Leu Phe Asn Met Leu Ile Met Cys Thr Ile Leu Thr Asn         
    130                 135                 140                         

tgc gtg ttc atg gcc cag cac gac cct cca ccc tgg acc aag tat gtc      480
Cys Val Phe Met Ala Gln His Asp Pro Pro Pro Trp Thr Lys Tyr Val         
145                 150                 155                 160         

gag tac acc ttc acc gcc att tac acc ttt gag tct ctg gtc aag att      528
Glu Tyr Thr Phe Thr Ala Ile Tyr Thr Phe Glu Ser Leu Val Lys Ile         
                165                 170                 175             

ctg gct cga gct ttc tgc ctg cac gcg ttc act ttc ctt cgg gac cca      576
Leu Ala Arg Ala Phe Cys Leu His Ala Phe Thr Phe Leu Arg Asp Pro         
            180                 185                 190                 

tgg aac tgg ctg gac ttt agt gtg att atc atg gca tac aca act gaa      624
Trp Asn Trp Leu Asp Phe Ser Val Ile Ile Met Ala Tyr Thr Thr Glu         
        195                 200                 205                     

ttt gtg gac ctg ggc aat gtc tca gcc tta cgc acc ttc cga gtc ctc      672
Phe Val Asp Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu         
    210                 215                 220                         

cgg gcc ctg aaa act ata tca gtc att tca ggg ctg aag acc atc gtg      720
Arg Ala Leu Lys Thr Ile Ser Val Ile Ser Gly Leu Lys Thr Ile Val         
225                 230                 235                 240         

ggg gcc ctg atc cag tct gtg aag aag ctg gct gat gtg atg gtc ctc      768
Gly Ala Leu Ile Gln Ser Val Lys Lys Leu Ala Asp Val Met Val Leu         
                245                 250                 255             

aca gtc ttc tgc ctc agc gtc ttt gcc ctc atc ggc ctg cag ctc ttc      816
Thr Val Phe Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe         
            260                 265                 270                 

atg ggc aac cta agg cac aag tgt gtg cgc aac ttc aca gcg ctc aac      864
Met Gly Asn Leu Arg His Lys Cys Val Arg Asn Phe Thr Ala Leu Asn         
        275                 280                 285                     

ggc acc aac ggc tcc gtg gag gcc gac ggc ttg gtc tgg gaa tcc ctg      912
Gly Thr Asn Gly Ser Val Glu Ala Asp Gly Leu Val Trp Glu Ser Leu         
    290                 295                 300                         

gac ctt tac ctc agt gat cca gaa aat tac ctg ctc aag aac ggc acc      960
Asp Leu Tyr Leu Ser Asp Pro Glu Asn Tyr Leu Leu Lys Asn Gly Thr         
305                 310                 315                 320         

tct gat gtg tta ctg tgt ggg aac agc tct gac gct ggg aca tgt ccg     1008
Ser Asp Val Leu Leu Cys Gly Asn Ser Ser Asp Ala Gly Thr Cys Pro         
                325                 330                 335             

gag ggc tac cgg tgc cta aag gca ggc gag aac ccc gac cac ggc tac     1056
Glu Gly Tyr Arg Cys Leu Lys Ala Gly Glu Asn Pro Asp His Gly Tyr         
            340                 345                 350                 

acc agc ttc gat tcc ttt gcc tgg gcc ttt ctt gca ctc ttc cgc ctg     1104
Thr Ser Phe Asp Ser Phe Ala Trp Ala Phe Leu Ala Leu Phe Arg Leu         
        355                 360                 365                     

atg acg cag gac tgc tgg gag cgc ctc tat cag cag acc ctc agg tcc     1152
Met Thr Gln Asp Cys Trp Glu Arg Leu Tyr Gln Gln Thr Leu Arg Ser         
    370                 375                 380                         

gca ggg aag atc tac atg atc ttc ttc atg ctt gtc atc ttc ctg ggg     1200
Ala Gly Lys Ile Tyr Met Ile Phe Phe Met Leu Val Ile Phe Leu Gly         
385                 390                 395                 400         

tcc ttc tac ctg gtg aac ctg atc ctg gcc gtg gtc gca atg gcc tat     1248
Ser Phe Tyr Leu Val Asn Leu Ile Leu Ala Val Val Ala Met Ala Tyr         
                405                 410                 415             

gag gag caa aac caa gcc acc atc gct gag acc gag gag aag gaa aag     1296
Glu Glu Gln Asn Gln Ala Thr Ile Ala Glu Thr Glu Glu Lys Glu Lys         
            420                 425                 430                 

cgc ttc cag gag gcc atg gaa atg ctc aag aaa gaa cac gag gcc ctc     1344
Arg Phe Gln Glu Ala Met Glu Met Leu Lys Lys Glu His Glu Ala Leu         
        435                 440                 445                     

acc atc agg ggt gtg gat acc gtg tcc cgt agc tcc ttg gag atg tcc     1392
Thr Ile Arg Gly Val Asp Thr Val Ser Arg Ser Ser Leu Glu Met Ser         
    450                 455                 460                         

cct ttg gcc cca gta aac agc cat gag aga aga agc aag agg aga aaa     1440
Pro Leu Ala Pro Val Asn Ser His Glu Arg Arg Ser Lys Arg Arg Lys         
465                 470                 475                 480         

cgg atg tct tca gga act gag gag tgt ggg gag gac agg ctc ccc aag     1488
Arg Met Ser Ser Gly Thr Glu Glu Cys Gly Glu Asp Arg Leu Pro Lys         
                485                 490                 495             

tct gac tca gaa gat ggt ccc aga gca atg aat cat ctc agc ctc acc     1536
Ser Asp Ser Glu Asp Gly Pro Arg Ala Met Asn His Leu Ser Leu Thr         
            500                 505                 510                 

cgt ggc ctc agc agg act tct atg aag cca cgt tcc agc cgc ggg agc     1584
Arg Gly Leu Ser Arg Thr Ser Met Lys Pro Arg Ser Ser Arg Gly Ser         
        515                 520                 525                     

att ttc acc ttt cgc agg cga gac ctg ggt tct gaa gca gat ttt gca     1632
Ile Phe Thr Phe Arg Arg Arg Asp Leu Gly Ser Glu Ala Asp Phe Ala         
    530                 535                 540                         

gat gat gaa aac agc aca gcg cgg gag agc gag agc cac cac aca tca     1680
Asp Asp Glu Asn Ser Thr Ala Arg Glu Ser Glu Ser His His Thr Ser         
545                 550                 555                 560         

ctg ctg gtg ccc tgg ccc ctg cgc cgg acc agt gcc cag gga cag ccc     1728
Leu Leu Val Pro Trp Pro Leu Arg Arg Thr Ser Ala Gln Gly Gln Pro         
                565                 570                 575             

agt ccc gga acc tcg gct cct ggc cac gcc ctc cat ggc aaa aag aac     1776
Ser Pro Gly Thr Ser Ala Pro Gly His Ala Leu His Gly Lys Lys Asn         
            580                 585                 590                 

agc act gtg gac tgc aat ggg gtg gtc tca tta ctg ggg gca ggc gac     1824
Ser Thr Val Asp Cys Asn Gly Val Val Ser Leu Leu Gly Ala Gly Asp         
        595                 600                 605                     

cca gag gcc aca tcc cca gga agc cac ctc ctc cgc cct gtg atg cta     1872
Pro Glu Ala Thr Ser Pro Gly Ser His Leu Leu Arg Pro Val Met Leu         
    610                 615                 620                         

gag cac ccg cca gac acg acc acg cca tcg gag gag cca ggc ggc ccc     1920
Glu His Pro Pro Asp Thr Thr Thr Pro Ser Glu Glu Pro Gly Gly Pro         
625                 630                 635                 640         

cag atg ctg acc tcc cag gct ccg tgt gta gat ggc ttc gag gag cca     1968
Gln Met Leu Thr Ser Gln Ala Pro Cys Val Asp Gly Phe Glu Glu Pro         
                645                 650                 655             

gga gca cgg cag cgg gcc ctc agc gca gtc agc gtc ctc aca agc gca     2016
Gly Ala Arg Gln Arg Ala Leu Ser Ala Val Ser Val Leu Thr Ser Ala         
            660                 665                 670                 

ctg gaa gag tta gag gag tct cgc cac aag tgt cca cca tgc tgg aac     2064
Leu Glu Glu Leu Glu Glu Ser Arg His Lys Cys Pro Pro Cys Trp Asn         
        675                 680                 685                     

cgt ctc gcc cag cgc tac ctg atc tgg gag tgc tgc ccg ctg tgg atg     2112
Arg Leu Ala Gln Arg Tyr Leu Ile Trp Glu Cys Cys Pro Leu Trp Met         
    690                 695                 700                         

tcc atc aag cag gga gtg aag ttg gtg gtc atg gac ccg ttt act gac     2160
Ser Ile Lys Gln Gly Val Lys Leu Val Val Met Asp Pro Phe Thr Asp         
705                 710                 715                 720         

ctc acc atc act atg tgc atc gta ctc aac aca ctc ttc atg gcg ctg     2208
Leu Thr Ile Thr Met Cys Ile Val Leu Asn Thr Leu Phe Met Ala Leu         
                725                 730                 735             

gag cac tac aac atg aca agt gaa ttc gag gag atg ctg cag gtc gga     2256
Glu His Tyr Asn Met Thr Ser Glu Phe Glu Glu Met Leu Gln Val Gly         
            740                 745                 750                 

aac ctg gtc ttc aca ggg att ttc aca gca gag atg acc ttc aag atc     2304
Asn Leu Val Phe Thr Gly Ile Phe Thr Ala Glu Met Thr Phe Lys Ile         
        755                 760                 765                     

att gcc ctc gac ccc tac tac tac ttc caa cag ggc tgg aac atc ttc     2352
Ile Ala Leu Asp Pro Tyr Tyr Tyr Phe Gln Gln Gly Trp Asn Ile Phe         
    770                 775                 780                         

gac agc atc atc gtc atc ctt agc ctc atg gag ctg ggc ctg tcc cgc     2400
Asp Ser Ile Ile Val Ile Leu Ser Leu Met Glu Leu Gly Leu Ser Arg         
785                 790                 795                 800         

atg agc aac ttg tcg gtg ctg cgc tcc ttc cgc ctg ctg cgg gtc ttc     2448
Met Ser Asn Leu Ser Val Leu Arg Ser Phe Arg Leu Leu Arg Val Phe         
                805                 810                 815             

aag ctg gcc aaa tca tgg ccc acc ctg aac aca ctc atc aag atc atc     2496
Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Thr Leu Ile Lys Ile Ile         
            820                 825                 830                 

ggg aac tca gtg ggg gca ctg ggg aac ctg aca ctg gtg cta gcc atc     2544
Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu Val Leu Ala Ile         
        835                 840                 845                     

atc gtg ttc atc ttt gct gtg gtg ggc atg cag ctc ttt ggc aag aac     2592
Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu Phe Gly Lys Asn         
    850                 855                 860                         

tac tcg gag ctg agg gac agc gac tca ggc ctg ctg cct cgc tgg cac     2640
Tyr Ser Glu Leu Arg Asp Ser Asp Ser Gly Leu Leu Pro Arg Trp His         
865                 870                 875                 880         

atg atg gac ttc ttt cat gcc ttc cta atc atc ttc cgc atc ctc tgt     2688
Met Met Asp Phe Phe His Ala Phe Leu Ile Ile Phe Arg Ile Leu Cys         
                885                 890                 895             

gga gag tgg atc gag acc atg tgg gac tgc atg gag gtg tcg ggg cag     2736
Gly Glu Trp Ile Glu Thr Met Trp Asp Cys Met Glu Val Ser Gly Gln         
            900                 905                 910                 

tca tta tgc ctg ctg gtc ttc ttg ctt gtt atg gtc att ggc aac ctt     2784
Ser Leu Cys Leu Leu Val Phe Leu Leu Val Met Val Ile Gly Asn Leu         
        915                 920                 925                     

gtg gtc ctg aat ctc ttc ctg gcc ttg ctg ctc agc tcc ttc agt gca     2832
Val Val Leu Asn Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe Ser Ala         
    930                 935                 940                         

gac aac ctc aca gcc cct gat gag gac aga gag atg aac aac ctc cag     2880
Asp Asn Leu Thr Ala Pro Asp Glu Asp Arg Glu Met Asn Asn Leu Gln         
945                 950                 955                 960         

ctg gcc ctg gcc cgc atc cag agg ggc ctg cgc ttt gtc aag cgg acc     2928
Leu Ala Leu Ala Arg Ile Gln Arg Gly Leu Arg Phe Val Lys Arg Thr         
                965                 970                 975             

acc tgg gat ttc tgc tgt ggt ctc ctg cgg cac cgg cct cag aag ccc     2976
Thr Trp Asp Phe Cys Cys Gly Leu Leu Arg His Arg Pro Gln Lys Pro         
            980                 985                 990                 

gca gcc ctt gcc gcc cag ggc cag  ctg ccc agc tgc att  gcc acc ccc   3024
Ala Ala Leu Ala Ala Gln Gly Gln  Leu Pro Ser Cys Ile  Ala Thr Pro       
        995                 1000                 1005                   

tac tcc  ccg cca ccc cca gag  acg gag aag gtg cct  ccc acc cgc      3069
Tyr Ser  Pro Pro Pro Pro Glu  Thr Glu Lys Val Pro  Pro Thr Arg          
    1010                 1015                 1020                      

aag gaa  aca cag ttt gag gaa  ggc gag caa cca ggc  cag ggc acc      3114
Lys Glu  Thr Gln Phe Glu Glu  Gly Glu Gln Pro Gly  Gln Gly Thr          
    1025                 1030                 1035                      

ccc ggg  gat cca gag ccc gtg  tgt gtg ccc atc gct  gtg gcc gag      3159
Pro Gly  Asp Pro Glu Pro Val  Cys Val Pro Ile Ala  Val Ala Glu          
    1040                 1045                 1050                      

tca gac  aca gat gac caa gaa  gag gat gag gag aac  agc ctg ggc      3204
Ser Asp  Thr Asp Asp Gln Glu  Glu Asp Glu Glu Asn  Ser Leu Gly          
    1055                 1060                 1065                      

acg gag  gag gag tcc agc aag  cag cag gaa tcc cag  cct gtg tcc      3249
Thr Glu  Glu Glu Ser Ser Lys  Gln Gln Glu Ser Gln  Pro Val Ser          
    1070                 1075                 1080                      

ggc tgg  ccc aga ggc cct ccg  gat tcc agg acc tgg  agc cag gtg      3294
Gly Trp  Pro Arg Gly Pro Pro  Asp Ser Arg Thr Trp  Ser Gln Val          
    1085                 1090                 1095                      

tca gcg  act gcc tcc tct gag  gcc gag gcc agt gca  tct cag gcc      3339
Ser Ala  Thr Ala Ser Ser Glu  Ala Glu Ala Ser Ala  Ser Gln Ala          
    1100                 1105                 1110                      

gac tgg  cgg cag cag tgg aaa  gcg gaa ccc cag gcc  cca ggg tgc      3384
Asp Trp  Arg Gln Gln Trp Lys  Ala Glu Pro Gln Ala  Pro Gly Cys          
    1115                 1120                 1125                      

ggt gag  acc cca gag gac agt  tgc tcc gag ggc agc  aca gca gac      3429
Gly Glu  Thr Pro Glu Asp Ser  Cys Ser Glu Gly Ser  Thr Ala Asp          
    1130                 1135                 1140                      

atg acc  aac acc gct gag ctc  ctg gag cag atc cct  gac ctc ggc      3474
Met Thr  Asn Thr Ala Glu Leu  Leu Glu Gln Ile Pro  Asp Leu Gly          
    1145                 1150                 1155                      

cag gat  gtc aag gac cca gag  gac tgc ttc act gaa  ggc tgt gtc      3519
Gln Asp  Val Lys Asp Pro Glu  Asp Cys Phe Thr Glu  Gly Cys Val          
    1160                 1165                 1170                      

cgg cgc  tgt ccc tgc tgt gcg  gtg gac acc aca cag  gcc cca ggg      3564
Arg Arg  Cys Pro Cys Cys Ala  Val Asp Thr Thr Gln  Ala Pro Gly          
    1175                 1180                 1185                      

aag gtc  tgg tgg cgg ttg cgc  aag acc tgc tac cac  atc gtg gag      3609
Lys Val  Trp Trp Arg Leu Arg  Lys Thr Cys Tyr His  Ile Val Glu          
    1190                 1195                 1200                      

cac agc  tgg ttc gag aca ttc  atc atc ttc atg atc  cta ctc agc      3654
His Ser  Trp Phe Glu Thr Phe  Ile Ile Phe Met Ile  Leu Leu Ser          
    1205                 1210                 1215                      

agt gga  gcg ctg gcc ttc gag  gac atc tac cta gag  gag cgg aag      3699
Ser Gly  Ala Leu Ala Phe Glu  Asp Ile Tyr Leu Glu  Glu Arg Lys          
    1220                 1225                 1230                      

acc atc  aag gtt ctg ctt gag  tat gcc gac aag atg  ttc aca tat      3744
Thr Ile  Lys Val Leu Leu Glu  Tyr Ala Asp Lys Met  Phe Thr Tyr          
    1235                 1240                 1245                      

gtc ttc  gtg ctg gag atg ctg  ctc aag tgg gtg gcc  tac ggc ttc      3789
Val Phe  Val Leu Glu Met Leu  Leu Lys Trp Val Ala  Tyr Gly Phe          
    1250                 1255                 1260                      

aag aag  tac ttc acc aat gcc  tgg tgc tgg ctc gac  ttc ctc atc      3834
Lys Lys  Tyr Phe Thr Asn Ala  Trp Cys Trp Leu Asp  Phe Leu Ile          
    1265                 1270                 1275                      

gta gac  gtc tct ctg gtc agc  ctg gtg gcc aac acc  ctg ggc ttt      3879
Val Asp  Val Ser Leu Val Ser  Leu Val Ala Asn Thr  Leu Gly Phe          
    1280                 1285                 1290                      

gcc gag  atg ggc ccc atc aag  tca ctg cgg acg ctg  cgt gca ctc      3924
Ala Glu  Met Gly Pro Ile Lys  Ser Leu Arg Thr Leu  Arg Ala Leu          
    1295                 1300                 1305                      

cgt cct  ctg aga gct ctg tca  cga ttt gag ggc atg  agg gtg gtg      3969
Arg Pro  Leu Arg Ala Leu Ser  Arg Phe Glu Gly Met  Arg Val Val          
    1310                 1315                 1320                      

gtc aat  gcc ctg gtg ggc gcc  atc ccg tcc atc atg  aac gtc ctc      4014
Val Asn  Ala Leu Val Gly Ala  Ile Pro Ser Ile Met  Asn Val Leu          
    1325                 1330                 1335                      

ctc gtc  tgc ctc atc ttc tgg  ctc atc ttc agc atc  atg ggc gtg      4059
Leu Val  Cys Leu Ile Phe Trp  Leu Ile Phe Ser Ile  Met Gly Val          
    1340                 1345                 1350                      

aac ctc  ttt gcg ggg aag ttt  ggg agg tgc atc aac  cag aca gag      4104
Asn Leu  Phe Ala Gly Lys Phe  Gly Arg Cys Ile Asn  Gln Thr Glu          
    1355                 1360                 1365                      

gga gac  ttg cct ttg aac tac  acc atc gtg aac aac  aag agc cag      4149
Gly Asp  Leu Pro Leu Asn Tyr  Thr Ile Val Asn Asn  Lys Ser Gln          
    1370                 1375                 1380                      

tgt gag  tcc ttg aac ttg acc  gga gaa ttg tac tgg  acc aag gtg      4194
Cys Glu  Ser Leu Asn Leu Thr  Gly Glu Leu Tyr Trp  Thr Lys Val          
    1385                 1390                 1395                      

aaa gtc  aac ttt gac aac gtg  ggg gcc ggg tac ctg  gcc ctt ctg      4239
Lys Val  Asn Phe Asp Asn Val  Gly Ala Gly Tyr Leu  Ala Leu Leu          
    1400                 1405                 1410                      

cag gtg  gca aca ttt aaa ggc  tgg atg gac att atg  tat gca gct      4284
Gln Val  Ala Thr Phe Lys Gly  Trp Met Asp Ile Met  Tyr Ala Ala          
    1415                 1420                 1425                      

gtg gac  tcc agg ggg tat gaa  gag cag cct cag tgg  gaa tac aac      4329
Val Asp  Ser Arg Gly Tyr Glu  Glu Gln Pro Gln Trp  Glu Tyr Asn          
    1430                 1435                 1440                      

ctc tac  atg tac atc tat ttt  gtc att ttc atc atc  ttt ggg tct      4374
Leu Tyr  Met Tyr Ile Tyr Phe  Val Ile Phe Ile Ile  Phe Gly Ser          
    1445                 1450                 1455                      

ttc ttc  acc ctg aac ctc ttt  att ggt gtc atc att  gac aac ttc      4419
Phe Phe  Thr Leu Asn Leu Phe  Ile Gly Val Ile Ile  Asp Asn Phe          
    1460                 1465                 1470                      

aac caa  cag aag aaa aag tta  ggg ggc cag gac atc  ttc atg aca      4464
Asn Gln  Gln Lys Lys Lys Leu  Gly Gly Gln Asp Ile  Phe Met Thr          
    1475                 1480                 1485                      

gag gag  cag aag aag tac tac  aat gcc atg aag aag  ctg ggc tcc      4509
Glu Glu  Gln Lys Lys Tyr Tyr  Asn Ala Met Lys Lys  Leu Gly Ser          
    1490                 1495                 1500                      

aag aag  ccc cag aag ccc atc  cca cgg ccc ctg aac  aag tac cag      4554
Lys Lys  Pro Gln Lys Pro Ile  Pro Arg Pro Leu Asn  Lys Tyr Gln          
    1505                 1510                 1515                      

ggc ttc  ata ttc gac att gtg  acc aag cag gcc ttt  gac gtc acc      4599
Gly Phe  Ile Phe Asp Ile Val  Thr Lys Gln Ala Phe  Asp Val Thr          
    1520                 1525                 1530                      

atc atg  ttt ctg atc tgc ttg  aat atg gtg acc atg  atg gtg gag      4644
Ile Met  Phe Leu Ile Cys Leu  Asn Met Val Thr Met  Met Val Glu          
    1535                 1540                 1545                      

aca gat  gac caa agt cct gag  aaa atc aac atc ttg  gcc aag atc      4689
Thr Asp  Asp Gln Ser Pro Glu  Lys Ile Asn Ile Leu  Ala Lys Ile          
    1550                 1555                 1560                      

aac ctg  ctc ttt gtg gcc atc  ttc aca ggc gag tgt  att gtc aag      4734
Asn Leu  Leu Phe Val Ala Ile  Phe Thr Gly Glu Cys  Ile Val Lys          
    1565                 1570                 1575                      

ctg gct  gcc ctg cgc cac tac  tac ttc acc aac agc  tgg aat atc      4779
Leu Ala  Ala Leu Arg His Tyr  Tyr Phe Thr Asn Ser  Trp Asn Ile          
    1580                 1585                 1590                      

ttc gac  ttc gtg gtt gtc atc  ctc tcc atc gtg ggc  act gtg ctc      4824
Phe Asp  Phe Val Val Val Ile  Leu Ser Ile Val Gly  Thr Val Leu          
    1595                 1600                 1605                      

tcg gac  atc atc cag aag tac  ttc ttc tcc ccg acg  ctc ttc cga      4869
Ser Asp  Ile Ile Gln Lys Tyr  Phe Phe Ser Pro Thr  Leu Phe Arg          
    1610                 1615                 1620                      

gtc atc  cgc ctg gcc cga ata  ggc cgc atc ctc aga  ctg atc cga      4914
Val Ile  Arg Leu Ala Arg Ile  Gly Arg Ile Leu Arg  Leu Ile Arg          
    1625                 1630                 1635                      

ggg gcc  aag ggg atc cgc acg  ctg ctc ttt gcc ctc  atg atg tcc      4959
Gly Ala  Lys Gly Ile Arg Thr  Leu Leu Phe Ala Leu  Met Met Ser          
    1640                 1645                 1650                      

ctg cct  gcc ctc ttc aac atc  ggg ctg ctg ctc ttc  ctc gtc atg      5004
Leu Pro  Ala Leu Phe Asn Ile  Gly Leu Leu Leu Phe  Leu Val Met          
    1655                 1660                 1665                      

ttc atc  tac tcc atc ttt ggc  atg gcc aac ttc gct  tat gtc aag      5049
Phe Ile  Tyr Ser Ile Phe Gly  Met Ala Asn Phe Ala  Tyr Val Lys          
    1670                 1675                 1680                      

tgg gag  gct ggc atc gac gac  atg ttc aac ttc cag  acc ttc gcc      5094
Trp Glu  Ala Gly Ile Asp Asp  Met Phe Asn Phe Gln  Thr Phe Ala          
    1685                 1690                 1695                      

aac agc  atg ctg tgc ctc ttc  cag atc acc acg tcg  gcc ggc tgg      5139
Asn Ser  Met Leu Cys Leu Phe  Gln Ile Thr Thr Ser  Ala Gly Trp          
    1700                 1705                 1710                      

gat ggc  ctc ctc agc ccc atc  ctc aac act ggg ccg  ccc tac tgc      5184
Asp Gly  Leu Leu Ser Pro Ile  Leu Asn Thr Gly Pro  Pro Tyr Cys          
    1715                 1720                 1725                      

gac ccc  act ctg ccc aac agc  aat ggc tct cgg ggg  gac tgc ggg      5229
Asp Pro  Thr Leu Pro Asn Ser  Asn Gly Ser Arg Gly  Asp Cys Gly          
    1730                 1735                 1740                      

agc cca  gcc gtg ggc atc ctc  ttc ttc acc acc tac  atc atc atc      5274
Ser Pro  Ala Val Gly Ile Leu  Phe Phe Thr Thr Tyr  Ile Ile Ile          
    1745                 1750                 1755                      

tcc ttc  ctc atc gtg gtc aac  atg tac att gcc atc  atc ctg gag      5319
Ser Phe  Leu Ile Val Val Asn  Met Tyr Ile Ala Ile  Ile Leu Glu          
    1760                 1765                 1770                      

aac ttc  agc gtg gcc acg gag  gag agc acc gag ccc  ctg agt gag      5364
Asn Phe  Ser Val Ala Thr Glu  Glu Ser Thr Glu Pro  Leu Ser Glu          
    1775                 1780                 1785                      

gac gac  ttc gat atg ttc tat  gag atc tgg gag aaa  ttt gac cca      5409
Asp Asp  Phe Asp Met Phe Tyr  Glu Ile Trp Glu Lys  Phe Asp Pro          
    1790                 1795                 1800                      

gag gcc  act cag ttt att gag  tat tcg gtc ctg tct  gac ttt gcc      5454
Glu Ala  Thr Gln Phe Ile Glu  Tyr Ser Val Leu Ser  Asp Phe Ala          
    1805                 1810                 1815                      

gac gcc  ctg tct gag cca ctc  cgt atc gcc aag ccc  aac cag ata      5499
Asp Ala  Leu Ser Glu Pro Leu  Arg Ile Ala Lys Pro  Asn Gln Ile          
    1820                 1825                 1830                      

agc ctc  atc aac atg gac ctg  ccc atg gtg agt ggg  gac cgc atc      5544
Ser Leu  Ile Asn Met Asp Leu  Pro Met Val Ser Gly  Asp Arg Ile          
    1835                 1840                 1845                      

cat tgc  atg gac att ctc ttt  gcc ttc acc aaa agg  gtc ctg ggg      5589
His Cys  Met Asp Ile Leu Phe  Ala Phe Thr Lys Arg  Val Leu Gly          
    1850                 1855                 1860                      

gag tct  ggg gag atg gac gcc  ctg aag atc cag atg  gag gag aag      5634
Glu Ser  Gly Glu Met Asp Ala  Leu Lys Ile Gln Met  Glu Glu Lys          
    1865                 1870                 1875                      

ttc atg  gca gcc aac cca tcc  aag atc tcc tac gag  ccc atc acc      5679
Phe Met  Ala Ala Asn Pro Ser  Lys Ile Ser Tyr Glu  Pro Ile Thr          
    1880                 1885                 1890                      

acc aca  ctc cgg cgc aag cac  gaa gag gtg tcg gcc  atg gtt atc      5724
Thr Thr  Leu Arg Arg Lys His  Glu Glu Val Ser Ala  Met Val Ile          
    1895                 1900                 1905                      

cag aga  gcc ttc cgc agg cac  ctg ctg caa cgc tct  ttg aag cat      5769
Gln Arg  Ala Phe Arg Arg His  Leu Leu Gln Arg Ser  Leu Lys His          
    1910                 1915                 1920                      

gcc tcc  ttc ctc ttc cgt cag  cag gcg ggc agc ggc  ctc tcc gaa      5814
Ala Ser  Phe Leu Phe Arg Gln  Gln Ala Gly Ser Gly  Leu Ser Glu          
    1925                 1930                 1935                      

gag gat  gcc cct gag cga gag  ggc ctc atc gcc tac  gtg atg agt      5859
Glu Asp  Ala Pro Glu Arg Glu  Gly Leu Ile Ala Tyr  Val Met Ser          
    1940                 1945                 1950                      

gag aac  ttc tcc cga ccc ctt  ggc cca ccc tcc agc  tcc tcc atc      5904
Glu Asn  Phe Ser Arg Pro Leu  Gly Pro Pro Ser Ser  Ser Ser Ile          
    1955                 1960                 1965                      

tcc tcc  act tcc ttc cca ccc  tcc tat gac agt gtc  act aga gcc      5949
Ser Ser  Thr Ser Phe Pro Pro  Ser Tyr Asp Ser Val  Thr Arg Ala          
    1970                 1975                 1980                      

acc agc  gat aac ctc cag gtg  cgg ggg tct gac tac  agc cac agt      5994
Thr Ser  Asp Asn Leu Gln Val  Arg Gly Ser Asp Tyr  Ser His Ser          
    1985                 1990                 1995                      

gaa gat  ctc gcc gac ttc ccc  cct tct ccg gac agg  gac cgt gag      6039
Glu Asp  Leu Ala Asp Phe Pro  Pro Ser Pro Asp Arg  Asp Arg Glu          
    2000                 2005                 2010                      

tcc atc  gtg tga                                                    6051
Ser Ile  Val                                                            
    2015                                                                


<210>  6
<211>  2016
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ala Asn Phe Leu Leu Pro Arg Gly Thr Ser Ser Phe Arg Arg Phe 
1               5                   10                  15      


Thr Arg Glu Ser Leu Ala Ala Ile Glu Lys Arg Met Ala Glu Lys Gln 
            20                  25                  30          


Ala Arg Gly Ser Thr Thr Leu Gln Glu Ser Arg Glu Gly Leu Pro Glu 
        35                  40                  45              


Glu Glu Ala Pro Arg Pro Gln Leu Asp Leu Gln Ala Ser Lys Lys Leu 
    50                  55                  60                  


Pro Asp Leu Tyr Gly Asn Pro Pro Gln Glu Leu Ile Gly Glu Pro Leu 
65                  70                  75                  80  


Glu Asp Leu Asp Pro Phe Tyr Ser Thr Gln Lys Thr Phe Ile Val Leu 
                85                  90                  95      


Asn Lys Gly Lys Thr Ile Phe Arg Phe Ser Ala Thr Asn Ala Leu Tyr 
            100                 105                 110         


Val Leu Ser Pro Phe His Pro Val Arg Arg Ala Ala Val Lys Ile Leu 
        115                 120                 125             


Val His Ser Leu Phe Asn Met Leu Ile Met Cys Thr Ile Leu Thr Asn 
    130                 135                 140                 


Cys Val Phe Met Ala Gln His Asp Pro Pro Pro Trp Thr Lys Tyr Val 
145                 150                 155                 160 


Glu Tyr Thr Phe Thr Ala Ile Tyr Thr Phe Glu Ser Leu Val Lys Ile 
                165                 170                 175     


Leu Ala Arg Ala Phe Cys Leu His Ala Phe Thr Phe Leu Arg Asp Pro 
            180                 185                 190         


Trp Asn Trp Leu Asp Phe Ser Val Ile Ile Met Ala Tyr Thr Thr Glu 
        195                 200                 205             


Phe Val Asp Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu 
    210                 215                 220                 


Arg Ala Leu Lys Thr Ile Ser Val Ile Ser Gly Leu Lys Thr Ile Val 
225                 230                 235                 240 


Gly Ala Leu Ile Gln Ser Val Lys Lys Leu Ala Asp Val Met Val Leu 
                245                 250                 255     


Thr Val Phe Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe 
            260                 265                 270         


Met Gly Asn Leu Arg His Lys Cys Val Arg Asn Phe Thr Ala Leu Asn 
        275                 280                 285             


Gly Thr Asn Gly Ser Val Glu Ala Asp Gly Leu Val Trp Glu Ser Leu 
    290                 295                 300                 


Asp Leu Tyr Leu Ser Asp Pro Glu Asn Tyr Leu Leu Lys Asn Gly Thr 
305                 310                 315                 320 


Ser Asp Val Leu Leu Cys Gly Asn Ser Ser Asp Ala Gly Thr Cys Pro 
                325                 330                 335     


Glu Gly Tyr Arg Cys Leu Lys Ala Gly Glu Asn Pro Asp His Gly Tyr 
            340                 345                 350         


Thr Ser Phe Asp Ser Phe Ala Trp Ala Phe Leu Ala Leu Phe Arg Leu 
        355                 360                 365             


Met Thr Gln Asp Cys Trp Glu Arg Leu Tyr Gln Gln Thr Leu Arg Ser 
    370                 375                 380                 


Ala Gly Lys Ile Tyr Met Ile Phe Phe Met Leu Val Ile Phe Leu Gly 
385                 390                 395                 400 


Ser Phe Tyr Leu Val Asn Leu Ile Leu Ala Val Val Ala Met Ala Tyr 
                405                 410                 415     


Glu Glu Gln Asn Gln Ala Thr Ile Ala Glu Thr Glu Glu Lys Glu Lys 
            420                 425                 430         


Arg Phe Gln Glu Ala Met Glu Met Leu Lys Lys Glu His Glu Ala Leu 
        435                 440                 445             


Thr Ile Arg Gly Val Asp Thr Val Ser Arg Ser Ser Leu Glu Met Ser 
    450                 455                 460                 


Pro Leu Ala Pro Val Asn Ser His Glu Arg Arg Ser Lys Arg Arg Lys 
465                 470                 475                 480 


Arg Met Ser Ser Gly Thr Glu Glu Cys Gly Glu Asp Arg Leu Pro Lys 
                485                 490                 495     


Ser Asp Ser Glu Asp Gly Pro Arg Ala Met Asn His Leu Ser Leu Thr 
            500                 505                 510         


Arg Gly Leu Ser Arg Thr Ser Met Lys Pro Arg Ser Ser Arg Gly Ser 
        515                 520                 525             


Ile Phe Thr Phe Arg Arg Arg Asp Leu Gly Ser Glu Ala Asp Phe Ala 
    530                 535                 540                 


Asp Asp Glu Asn Ser Thr Ala Arg Glu Ser Glu Ser His His Thr Ser 
545                 550                 555                 560 


Leu Leu Val Pro Trp Pro Leu Arg Arg Thr Ser Ala Gln Gly Gln Pro 
                565                 570                 575     


Ser Pro Gly Thr Ser Ala Pro Gly His Ala Leu His Gly Lys Lys Asn 
            580                 585                 590         


Ser Thr Val Asp Cys Asn Gly Val Val Ser Leu Leu Gly Ala Gly Asp 
        595                 600                 605             


Pro Glu Ala Thr Ser Pro Gly Ser His Leu Leu Arg Pro Val Met Leu 
    610                 615                 620                 


Glu His Pro Pro Asp Thr Thr Thr Pro Ser Glu Glu Pro Gly Gly Pro 
625                 630                 635                 640 


Gln Met Leu Thr Ser Gln Ala Pro Cys Val Asp Gly Phe Glu Glu Pro 
                645                 650                 655     


Gly Ala Arg Gln Arg Ala Leu Ser Ala Val Ser Val Leu Thr Ser Ala 
            660                 665                 670         


Leu Glu Glu Leu Glu Glu Ser Arg His Lys Cys Pro Pro Cys Trp Asn 
        675                 680                 685             


Arg Leu Ala Gln Arg Tyr Leu Ile Trp Glu Cys Cys Pro Leu Trp Met 
    690                 695                 700                 


Ser Ile Lys Gln Gly Val Lys Leu Val Val Met Asp Pro Phe Thr Asp 
705                 710                 715                 720 


Leu Thr Ile Thr Met Cys Ile Val Leu Asn Thr Leu Phe Met Ala Leu 
                725                 730                 735     


Glu His Tyr Asn Met Thr Ser Glu Phe Glu Glu Met Leu Gln Val Gly 
            740                 745                 750         


Asn Leu Val Phe Thr Gly Ile Phe Thr Ala Glu Met Thr Phe Lys Ile 
        755                 760                 765             


Ile Ala Leu Asp Pro Tyr Tyr Tyr Phe Gln Gln Gly Trp Asn Ile Phe 
    770                 775                 780                 


Asp Ser Ile Ile Val Ile Leu Ser Leu Met Glu Leu Gly Leu Ser Arg 
785                 790                 795                 800 


Met Ser Asn Leu Ser Val Leu Arg Ser Phe Arg Leu Leu Arg Val Phe 
                805                 810                 815     


Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Thr Leu Ile Lys Ile Ile 
            820                 825                 830         


Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu Val Leu Ala Ile 
        835                 840                 845             


Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu Phe Gly Lys Asn 
    850                 855                 860                 


Tyr Ser Glu Leu Arg Asp Ser Asp Ser Gly Leu Leu Pro Arg Trp His 
865                 870                 875                 880 


Met Met Asp Phe Phe His Ala Phe Leu Ile Ile Phe Arg Ile Leu Cys 
                885                 890                 895     


Gly Glu Trp Ile Glu Thr Met Trp Asp Cys Met Glu Val Ser Gly Gln 
            900                 905                 910         


Ser Leu Cys Leu Leu Val Phe Leu Leu Val Met Val Ile Gly Asn Leu 
        915                 920                 925             


Val Val Leu Asn Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe Ser Ala 
    930                 935                 940                 


Asp Asn Leu Thr Ala Pro Asp Glu Asp Arg Glu Met Asn Asn Leu Gln 
945                 950                 955                 960 


Leu Ala Leu Ala Arg Ile Gln Arg Gly Leu Arg Phe Val Lys Arg Thr 
                965                 970                 975     


Thr Trp Asp Phe Cys Cys Gly Leu Leu Arg His Arg Pro Gln Lys Pro 
            980                 985                 990         


Ala Ala Leu Ala Ala Gln Gly Gln  Leu Pro Ser Cys Ile  Ala Thr Pro 
        995                 1000                 1005             


Tyr Ser  Pro Pro Pro Pro Glu  Thr Glu Lys Val Pro  Pro Thr Arg 
    1010                 1015                 1020             


Lys Glu  Thr Gln Phe Glu Glu  Gly Glu Gln Pro Gly  Gln Gly Thr 
    1025                 1030                 1035             


Pro Gly  Asp Pro Glu Pro Val  Cys Val Pro Ile Ala  Val Ala Glu 
    1040                 1045                 1050             


Ser Asp  Thr Asp Asp Gln Glu  Glu Asp Glu Glu Asn  Ser Leu Gly 
    1055                 1060                 1065             


Thr Glu  Glu Glu Ser Ser Lys  Gln Gln Glu Ser Gln  Pro Val Ser 
    1070                 1075                 1080             


Gly Trp  Pro Arg Gly Pro Pro  Asp Ser Arg Thr Trp  Ser Gln Val 
    1085                 1090                 1095             


Ser Ala  Thr Ala Ser Ser Glu  Ala Glu Ala Ser Ala  Ser Gln Ala 
    1100                 1105                 1110             


Asp Trp  Arg Gln Gln Trp Lys  Ala Glu Pro Gln Ala  Pro Gly Cys 
    1115                 1120                 1125             


Gly Glu  Thr Pro Glu Asp Ser  Cys Ser Glu Gly Ser  Thr Ala Asp 
    1130                 1135                 1140             


Met Thr  Asn Thr Ala Glu Leu  Leu Glu Gln Ile Pro  Asp Leu Gly 
    1145                 1150                 1155             


Gln Asp  Val Lys Asp Pro Glu  Asp Cys Phe Thr Glu  Gly Cys Val 
    1160                 1165                 1170             


Arg Arg  Cys Pro Cys Cys Ala  Val Asp Thr Thr Gln  Ala Pro Gly 
    1175                 1180                 1185             


Lys Val  Trp Trp Arg Leu Arg  Lys Thr Cys Tyr His  Ile Val Glu 
    1190                 1195                 1200             


His Ser  Trp Phe Glu Thr Phe  Ile Ile Phe Met Ile  Leu Leu Ser 
    1205                 1210                 1215             


Ser Gly  Ala Leu Ala Phe Glu  Asp Ile Tyr Leu Glu  Glu Arg Lys 
    1220                 1225                 1230             


Thr Ile  Lys Val Leu Leu Glu  Tyr Ala Asp Lys Met  Phe Thr Tyr 
    1235                 1240                 1245             


Val Phe  Val Leu Glu Met Leu  Leu Lys Trp Val Ala  Tyr Gly Phe 
    1250                 1255                 1260             


Lys Lys  Tyr Phe Thr Asn Ala  Trp Cys Trp Leu Asp  Phe Leu Ile 
    1265                 1270                 1275             


Val Asp  Val Ser Leu Val Ser  Leu Val Ala Asn Thr  Leu Gly Phe 
    1280                 1285                 1290             


Ala Glu  Met Gly Pro Ile Lys  Ser Leu Arg Thr Leu  Arg Ala Leu 
    1295                 1300                 1305             


Arg Pro  Leu Arg Ala Leu Ser  Arg Phe Glu Gly Met  Arg Val Val 
    1310                 1315                 1320             


Val Asn  Ala Leu Val Gly Ala  Ile Pro Ser Ile Met  Asn Val Leu 
    1325                 1330                 1335             


Leu Val  Cys Leu Ile Phe Trp  Leu Ile Phe Ser Ile  Met Gly Val 
    1340                 1345                 1350             


Asn Leu  Phe Ala Gly Lys Phe  Gly Arg Cys Ile Asn  Gln Thr Glu 
    1355                 1360                 1365             


Gly Asp  Leu Pro Leu Asn Tyr  Thr Ile Val Asn Asn  Lys Ser Gln 
    1370                 1375                 1380             


Cys Glu  Ser Leu Asn Leu Thr  Gly Glu Leu Tyr Trp  Thr Lys Val 
    1385                 1390                 1395             


Lys Val  Asn Phe Asp Asn Val  Gly Ala Gly Tyr Leu  Ala Leu Leu 
    1400                 1405                 1410             


Gln Val  Ala Thr Phe Lys Gly  Trp Met Asp Ile Met  Tyr Ala Ala 
    1415                 1420                 1425             


Val Asp  Ser Arg Gly Tyr Glu  Glu Gln Pro Gln Trp  Glu Tyr Asn 
    1430                 1435                 1440             


Leu Tyr  Met Tyr Ile Tyr Phe  Val Ile Phe Ile Ile  Phe Gly Ser 
    1445                 1450                 1455             


Phe Phe  Thr Leu Asn Leu Phe  Ile Gly Val Ile Ile  Asp Asn Phe 
    1460                 1465                 1470             


Asn Gln  Gln Lys Lys Lys Leu  Gly Gly Gln Asp Ile  Phe Met Thr 
    1475                 1480                 1485             


Glu Glu  Gln Lys Lys Tyr Tyr  Asn Ala Met Lys Lys  Leu Gly Ser 
    1490                 1495                 1500             


Lys Lys  Pro Gln Lys Pro Ile  Pro Arg Pro Leu Asn  Lys Tyr Gln 
    1505                 1510                 1515             


Gly Phe  Ile Phe Asp Ile Val  Thr Lys Gln Ala Phe  Asp Val Thr 
    1520                 1525                 1530             


Ile Met  Phe Leu Ile Cys Leu  Asn Met Val Thr Met  Met Val Glu 
    1535                 1540                 1545             


Thr Asp  Asp Gln Ser Pro Glu  Lys Ile Asn Ile Leu  Ala Lys Ile 
    1550                 1555                 1560             


Asn Leu  Leu Phe Val Ala Ile  Phe Thr Gly Glu Cys  Ile Val Lys 
    1565                 1570                 1575             


Leu Ala  Ala Leu Arg His Tyr  Tyr Phe Thr Asn Ser  Trp Asn Ile 
    1580                 1585                 1590             


Phe Asp  Phe Val Val Val Ile  Leu Ser Ile Val Gly  Thr Val Leu 
    1595                 1600                 1605             


Ser Asp  Ile Ile Gln Lys Tyr  Phe Phe Ser Pro Thr  Leu Phe Arg 
    1610                 1615                 1620             


Val Ile  Arg Leu Ala Arg Ile  Gly Arg Ile Leu Arg  Leu Ile Arg 
    1625                 1630                 1635             


Gly Ala  Lys Gly Ile Arg Thr  Leu Leu Phe Ala Leu  Met Met Ser 
    1640                 1645                 1650             


Leu Pro  Ala Leu Phe Asn Ile  Gly Leu Leu Leu Phe  Leu Val Met 
    1655                 1660                 1665             


Phe Ile  Tyr Ser Ile Phe Gly  Met Ala Asn Phe Ala  Tyr Val Lys 
    1670                 1675                 1680             


Trp Glu  Ala Gly Ile Asp Asp  Met Phe Asn Phe Gln  Thr Phe Ala 
    1685                 1690                 1695             


Asn Ser  Met Leu Cys Leu Phe  Gln Ile Thr Thr Ser  Ala Gly Trp 
    1700                 1705                 1710             


Asp Gly  Leu Leu Ser Pro Ile  Leu Asn Thr Gly Pro  Pro Tyr Cys 
    1715                 1720                 1725             


Asp Pro  Thr Leu Pro Asn Ser  Asn Gly Ser Arg Gly  Asp Cys Gly 
    1730                 1735                 1740             


Ser Pro  Ala Val Gly Ile Leu  Phe Phe Thr Thr Tyr  Ile Ile Ile 
    1745                 1750                 1755             


Ser Phe  Leu Ile Val Val Asn  Met Tyr Ile Ala Ile  Ile Leu Glu 
    1760                 1765                 1770             


Asn Phe  Ser Val Ala Thr Glu  Glu Ser Thr Glu Pro  Leu Ser Glu 
    1775                 1780                 1785             


Asp Asp  Phe Asp Met Phe Tyr  Glu Ile Trp Glu Lys  Phe Asp Pro 
    1790                 1795                 1800             


Glu Ala  Thr Gln Phe Ile Glu  Tyr Ser Val Leu Ser  Asp Phe Ala 
    1805                 1810                 1815             


Asp Ala  Leu Ser Glu Pro Leu  Arg Ile Ala Lys Pro  Asn Gln Ile 
    1820                 1825                 1830             


Ser Leu  Ile Asn Met Asp Leu  Pro Met Val Ser Gly  Asp Arg Ile 
    1835                 1840                 1845             


His Cys  Met Asp Ile Leu Phe  Ala Phe Thr Lys Arg  Val Leu Gly 
    1850                 1855                 1860             


Glu Ser  Gly Glu Met Asp Ala  Leu Lys Ile Gln Met  Glu Glu Lys 
    1865                 1870                 1875             


Phe Met  Ala Ala Asn Pro Ser  Lys Ile Ser Tyr Glu  Pro Ile Thr 
    1880                 1885                 1890             


Thr Thr  Leu Arg Arg Lys His  Glu Glu Val Ser Ala  Met Val Ile 
    1895                 1900                 1905             


Gln Arg  Ala Phe Arg Arg His  Leu Leu Gln Arg Ser  Leu Lys His 
    1910                 1915                 1920             


Ala Ser  Phe Leu Phe Arg Gln  Gln Ala Gly Ser Gly  Leu Ser Glu 
    1925                 1930                 1935             


Glu Asp  Ala Pro Glu Arg Glu  Gly Leu Ile Ala Tyr  Val Met Ser 
    1940                 1945                 1950             


Glu Asn  Phe Ser Arg Pro Leu  Gly Pro Pro Ser Ser  Ser Ser Ile 
    1955                 1960                 1965             


Ser Ser  Thr Ser Phe Pro Pro  Ser Tyr Asp Ser Val  Thr Arg Ala 
    1970                 1975                 1980             


Thr Ser  Asp Asn Leu Gln Val  Arg Gly Ser Asp Tyr  Ser His Ser 
    1985                 1990                 1995             


Glu Asp  Leu Ala Asp Phe Pro  Pro Ser Pro Asp Arg  Asp Arg Glu 
    2000                 2005                 2010             


Ser Ile  Val 
    2015     


<210>  7
<211>  405
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(390)
<223>  KCNE1 cDNA (GenBank Acc. N NM000219): nucleotides 626 to 1015

<400>  7
atg atc ctg tct aac acc aca gcg gtg acg ccc ttt ctg acc aag ctg       48
Met Ile Leu Ser Asn Thr Thr Ala Val Thr Pro Phe Leu Thr Lys Leu         
1               5                   10                  15              

tgg cag gag aca gtt cag cag ggt ggc aac atg tcg ggc ctg gcc cgc       96
Trp Gln Glu Thr Val Gln Gln Gly Gly Asn Met Ser Gly Leu Ala Arg         
            20                  25                  30                  

agg tcc ccc cgc agc agt gac ggc aag ctg gag gcc ctc tac gtc ctc      144
Arg Ser Pro Arg Ser Ser Asp Gly Lys Leu Glu Ala Leu Tyr Val Leu         
        35                  40                  45                      

atg gta ctg gga ttc ttc ggc ttc ttc acc ctg ggc atc atg ctg agc      192
Met Val Leu Gly Phe Phe Gly Phe Phe Thr Leu Gly Ile Met Leu Ser         
    50                  55                  60                          

tac atc cgc tcc aag aag ctg gag cac tcg aac gac cca ttc aac gtc      240
Tyr Ile Arg Ser Lys Lys Leu Glu His Ser Asn Asp Pro Phe Asn Val         
65                  70                  75                  80          

tac atc gag tcc gat gcc tgg caa gag aag gac aag gcc tat gtc cag      288
Tyr Ile Glu Ser Asp Ala Trp Gln Glu Lys Asp Lys Ala Tyr Val Gln         
                85                  90                  95              

gcc cgg gtc ctg gag agc tac agg tcg tgc tat gtc gtt gaa aac cat      336
Ala Arg Val Leu Glu Ser Tyr Arg Ser Cys Tyr Val Val Glu Asn His         
            100                 105                 110                 

ctg gcc ata gaa caa ccc aac aca cac ctt cct gag acg aag cct tcc      384
Leu Ala Ile Glu Gln Pro Asn Thr His Leu Pro Glu Thr Lys Pro Ser         
        115                 120                 125                     

cca tga accccaccac tggct                                             405
Pro                                                                     
                                                                        


<210>  8
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ile Leu Ser Asn Thr Thr Ala Val Thr Pro Phe Leu Thr Lys Leu 
1               5                   10                  15      


Trp Gln Glu Thr Val Gln Gln Gly Gly Asn Met Ser Gly Leu Ala Arg 
            20                  25                  30          


Arg Ser Pro Arg Ser Ser Asp Gly Lys Leu Glu Ala Leu Tyr Val Leu 
        35                  40                  45              


Met Val Leu Gly Phe Phe Gly Phe Phe Thr Leu Gly Ile Met Leu Ser 
    50                  55                  60                  


Tyr Ile Arg Ser Lys Lys Leu Glu His Ser Asn Asp Pro Phe Asn Val 
65                  70                  75                  80  


Tyr Ile Glu Ser Asp Ala Trp Gln Glu Lys Asp Lys Ala Tyr Val Gln 
                85                  90                  95      


Ala Arg Val Leu Glu Ser Tyr Arg Ser Cys Tyr Val Val Glu Asn His 
            100                 105                 110         


Leu Ala Ile Glu Gln Pro Asn Thr His Leu Pro Glu Thr Lys Pro Ser 
        115                 120                 125             


Pro 
    


<210>  9
<211>  372
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(372)
<223>  KCNE2 cDNA (GenBank Acc. N NM000335): nucleotides 509 to 880

<400>  9
atg tct act tta tcc aat ttc aca cag acg ctg gaa gac gtc ttc cga       48
Met Ser Thr Leu Ser Asn Phe Thr Gln Thr Leu Glu Asp Val Phe Arg         
1               5                   10                  15              

agg att ttt att act tat atg gac aat tgg cgc cag aac aca aca gct       96
Arg Ile Phe Ile Thr Tyr Met Asp Asn Trp Arg Gln Asn Thr Thr Ala         
            20                  25                  30                  

gag caa gag gcc ctc caa gcc aaa gtt gat gct gag aac ttc tac tat      144
Glu Gln Glu Ala Leu Gln Ala Lys Val Asp Ala Glu Asn Phe Tyr Tyr         
        35                  40                  45                      

gtc atc ctg tac ctc atg gtg atg att gga atg ttc tct ttc atc atc      192
Val Ile Leu Tyr Leu Met Val Met Ile Gly Met Phe Ser Phe Ile Ile         
    50                  55                  60                          

gtg gcc atc ctg gtg agc act gtg aaa tcc aag aga cgg gaa cac tcc      240
Val Ala Ile Leu Val Ser Thr Val Lys Ser Lys Arg Arg Glu His Ser         
65                  70                  75                  80          

aat gac ccc tac cac cag tac att gta gag gac tgg cag gaa aag tac      288
Asn Asp Pro Tyr His Gln Tyr Ile Val Glu Asp Trp Gln Glu Lys Tyr         
                85                  90                  95              

aag agc caa atc ttg aat cta gaa gaa tcg aag gcc acc atc cat gag      336
Lys Ser Gln Ile Leu Asn Leu Glu Glu Ser Lys Ala Thr Ile His Glu         
            100                 105                 110                 

aac att ggt gcg gct ggg ttc aaa atg tcc ccc tga                      372
Asn Ile Gly Ala Ala Gly Phe Lys Met Ser Pro                             
        115                 120                                         


<210>  10
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ser Thr Leu Ser Asn Phe Thr Gln Thr Leu Glu Asp Val Phe Arg 
1               5                   10                  15      


Arg Ile Phe Ile Thr Tyr Met Asp Asn Trp Arg Gln Asn Thr Thr Ala 
            20                  25                  30          


Glu Gln Glu Ala Leu Gln Ala Lys Val Asp Ala Glu Asn Phe Tyr Tyr 
        35                  40                  45              


Val Ile Leu Tyr Leu Met Val Met Ile Gly Met Phe Ser Phe Ile Ile 
    50                  55                  60                  


Val Ala Ile Leu Val Ser Thr Val Lys Ser Lys Arg Arg Glu His Ser 
65                  70                  75                  80  


Asn Asp Pro Tyr His Gln Tyr Ile Val Glu Asp Trp Gln Glu Lys Tyr 
                85                  90                  95      


Lys Ser Gln Ile Leu Asn Leu Glu Glu Ser Lys Ala Thr Ile His Glu 
            100                 105                 110         


Asn Ile Gly Ala Ala Gly Phe Lys Met Ser Pro 
        115                 120             


<210>  11
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (5)..(5)
<223>  KCNQ1; G136A

<400>  11
cccgacggg                                                              9


<210>  12
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (6)..(6)
<223>  KCNQ1; 151-152insT

<400>  12
cgctcttac                                                              9


<210>  13
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (5)..(5)
<223>  KCNQ1; C409T

<400>  13
ctgcttcat                                                              9


<210>  14
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (5)..(5)
<223>  KCNQ1; G436A

<400>  14
catcaagca                                                              9


<210>  15
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (5)..(5)
<223>  KCNQ1; T518A

<400>  15
gtggaccgc                                                              9


<210>  16
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (5)..(5)
<223>  KCNQ1; G521C

<400>  16
gtccccctc                                                              9


<210>  17
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (5)..(5)
<223>  KCNQ1; C568T

<400>  17
ggggtggct                                                              9


<210>  18
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (5)..(5)
<223>  KCNQ1; G575C

<400>  18
ctgcccttt                                                              9


<210>  19
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  KCNQ1; 584del

<400>  19
gcccgaagc                                                              9


<210>  20
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (5)..(5)
<223>  KCNQ1; G604C

<400>  20
catccgtga                                                              9


<210>  21
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (5)..(5)
<223>  KCNQ1; C612G

<400>  21
tcatggtgg                                                              9


<210>  22
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (5)..(5)
<223>  KCNQ1; C626T

<400>  22
gccttcatg                                                              9


<210>  23
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (5)..(5)
<223>  KCNQ1; G643A

<400>  23
ctgcatggg                                                              9


<210>  24
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (5)..(5)
<223>  KCNQ1; G692A

<400>  24
atccacttc                                                              9


<210>  25
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (5)..(5)
<223>  KCNQ1; T716C

<400>  25
atgccacac                                                              9


<210>  26
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (5)..(5)
<223>  KCNQ1; G760T

<400>  26
ctccttggt                                                              9


<210>  27
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (5)..(5)
<223>  KCNQ1; C772A

<400>  27
catcaaccg                                                              9


<210>  28
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (5)..(5)
<223>  KCNQ1; A773G

<400>  28
atccgccgc                                                              9


<210>  29
<211>  10
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (6)..(6)
<223>  KCNQ1; C784G

<400>  29
aggaggtgat                                                            10


<210>  30
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  KCNQ1; 796del

<400>  30
cacctgtac                                                              9


<210>  31
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (5)..(5)
<223>  KCNQ1; G815A

<400>  31
ctggacctc                                                              9


<210>  32
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  KCNQ1; 828-830del

<400>  32
tctcgtact                                                              9


<210>  33
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (5)..(5)
<223>  KCNQ1; C830G

<400>  33
tcctggtac                                                              9


<210>  34
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (5)..(5)
<223>  KCNQ1; T839A

<400>  34
tttgagtac                                                              9


<210>  35
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (5)..(5)
<223>  KCNQ1; C860A

<400>  35
gacgaggtg                                                              9


<210>  36
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (5)..(5)
<223>  KCNQ1; G904A

<400>  36
agatacgct                                                              9


<210>  37
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (5)..(5)
<223>  KCNQ1; T923A

<400>  37
caggacaca                                                              9


<210>  38
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (5)..(5)
<223>  KCNQ1; G947A

<400>  38
tatgaggac                                                              9


<210>  39
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (5)..(5)
<223>  KCNQ1; C965T

<400>  39
cagatgtgg                                                              9


<210>  40
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (5)..(5)
<223>  KCNQ1; C1028T

<400>  40
ctcctagcg                                                              9


<210>  41
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (5)..(5)
<223>  KCNQ1; C1028G

<400>  41
ctccgagcg                                                              9


<210>  42
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (5)..(5)
<223>  KCNQ1; T1045C

<400>  42
tggcccggg                                                              9


<210>  43
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (5)..(5)
<223>  KCNQ1; G1048C

<400>  43
ctcgcggtt                                                              9


<210>  44
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (5)..(5)
<223>  KCNQ1; T1052C

<400>  44
gggtctgcc                                                              9


<210>  45
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  KCNQ1; 1067-1072del

<400>  45
gtgcagcag                                                              9


<210>  46
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (5)..(5)
<223>  KCNQ1; G1079C

<400>  46
cagacgcag                                                              9


<210>  47
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (5)..(5)
<223>  KCNQ1; C1115A

<400>  47
gcagactca                                                              9


<210>  48
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (5)..(5)
<223>  KCNQ1; A1178T

<400>  48
tggatgatc                                                              9


<210>  49
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (5)..(5)
<223>  KCNQ1; 1291-1292insG

<400>  49
gggggtgac                                                              9


<210>  50
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (5)..(5)
<223>  KCCNQ1; 1292-1293insG

<400>  50
gggtggact                                                              9


<210>  51
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  KCNQ1; 1486-1487del

<400>  51
agactgctg                                                              9


<210>  52
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (5)..(5)
<223>  KCNQ1; 1514+1 G>A

<400>  52
cacaatgag                                                              9


<210>  53
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  KCNQ1; 1513-1514del

<400>  53
ctcagtgag                                                              9


<210>  54
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  KCNQ1, 1538delC

<400>  54
ggccacatt                                                              9


<210>  55
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (5)..(5)
<223>  KCNQ1; C1552G

<400>  55
cattggacg                                                              9


<210>  56
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (5)..(5)
<223>  KCNQ1; G1553C

<400>  56
attccacgc                                                              9


<210>  57
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (5)..(5)
<223>  KCNQ1; G1643A

<400>  57
caggaccac                                                              9


<210>  58
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (5)..(5)
<223>  KCNQ1; T1661C

<400>  58
atggcgcgc                                                              9


<210>  59
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (5)..(5)
<223>  KCNQ1, T1700C

<400>  59
tccactggg                                                              9


<210>  60
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  KCNQ1; 1710delC

<400>  60
aagcctcac                                                              9


<210>  61
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (5)..(5)
<223>  KCNQ1; C1719A

<400>  61
tgttaatct                                                              9


<210>  62
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  KCNQ1; 1725-1728del

<400>  62
atctctcag                                                              9


<210>  63
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (5)..(5)
<223>  KCNQ1; G1748A

<400>  63
gatcacggc                                                              9


<210>  64
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (5)..(5)
<223>  KCNQ1; A1756G

<400>  64
cagcgacac                                                              9


<210>  65
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  KCNQ1; 1893delC

<400>  65
cccccagag                                                              9


<210>  66
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  KCNQ1; 1909delC

<400>  66
gggccacat                                                              9


<210>  67
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (5)..(5)
<223>  KCNH2; A128G

<400>  67
atctgctgc                                                              9


<210>  68
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (5)..(5)
<223>  KCNH2; G146A

<400>  68
ttctgcgag                                                              9


<210>  69
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (5)..(5)
<223>  KCNH2; A173C

<400>  69
gccgcggtg                                                              9


<210>  70
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (5)..(5)
<223>  KCNH2; A173G

<400>  70
gccggggtg                                                              9


<210>  71
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (5)..(5)
<223>  KCNH2; G174C

<400>  71
ccgacgtga                                                              9


<210>  72
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (5)..(5)
<223>  KCNH2; T202C

<400>  72
cgacctcct                                                              9


<210>  73
<211>  10
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  KCNH2; G211C

<400>  73
gcacgggccg                                                            10


<210>  74
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (5)..(5)
<223>  KCNH2; C221T

<400>  74
cgcacgcag                                                              9


<210>  75
<211>  8
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  KCNH2; 244-252del

<400>  75
gcaggcac                                                               8


<210>  76
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (5)..(5)
<223>  KCNH2; 308-310ins ATG

<400>  76
gatgatggt                                                              9


<210>  77
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  KCNH2, 337-339del

<400>  77
tgtgcccgt                                                              9


<210>  78
<211>  10
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (4)..(8)
<223>  KCNH2; 557-566del/Ins+TTCGC

<400>  78
cggttcgccg                                                            10


<210>  79
<211>  8
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  KCNH2; 576delG

<400>  79
ccggggcc                                                               8


<210>  80
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  KCNH2; 578-582del

<400>  80
gggggtggt                                                              9


<210>  81
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (3)..(4)
<223>  KCNH2; 735-6InsCC

<400>  81
gcccccggc                                                              9


<210>  82
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (5)..(5)
<223>  KCNH2; C751T

<400>  82
atcgtcccg                                                              9


<210>  83
<211>  8
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (5)..(5)
<223>  KCNH2; C1171T

<400>  83
gctgtagg                                                               8


<210>  84
<211>  10
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (6)..(6)
<223>  KCNH2; G1229C

<400>  84
cgtgtcggac                                                            10


<210>  85
<211>  10
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (7)..(7)
<223>  KCNH2; G1235A

<400>  85
ggactgactc                                                            10


<210>  86
<211>  10
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (5)..(5)
<223>  KCNH2; C1277A

<400>  86
cacacactac                                                            10


<210>  87
<211>  10
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (5)..(5)
<223>  KCNH2; T1279C

<400>  87
accccactcg                                                            10


<210>  88
<211>  10
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (6)..(6)
<223>  KCNH2; C1283T

<400>  88
ctacttggct                                                            10


<210>  89
<211>  10
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (5)..(5)
<223>  KCNH2; G1378T

<400>  89
cgtgtacatc                                                            10


<210>  90
<211>  10
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (5)..(5)
<223>  KCNH2; G1501C

<400>  90
catccacatg                                                            10


<210>  91
<211>  10
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (5)..(5)
<223>  KCNH2, G1601T

<400>  91
ggtgctcgtg                                                            10


<210>  92
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  KCNH2; 1613-1619del

<400>  92
cggatcgct                                                              9


<210>  93
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (5)..(5)
<223>  KCNH2; G1697C

<400>  93
gcctccatc                                                              9


<210>  94
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  KCNH2; 1701delC

<400>  94
tgcattggt                                                              9


<210>  95
<211>  10
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (5)..(5)
<223>  KCNH2; T1702C

<400>  95
catccggtac                                                            10


<210>  96
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (5)..(5)
<223>  KCNH2; A1711G

<400>  96
cgccgtcgc                                                              9


<210>  97
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (6)..(6)
<223>  KCNH2; G1715A

<400>  97
catcgacaa                                                              9


<210>  98
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (5)..(5)
<223>  KCNH2; G1745T

<400>  98
tcactcatc                                                              9


<210>  99
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (4)..(4)
<223>  KCNH2; G1825C

<400>  99
aagcacaag                                                              9


<210>  100
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (4)..(4)
<223>  KCNH2; C1843T

<400>  100
gcgttctac                                                              9


<210>  101
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (5)..(5)
<223>  KCNH2; C1863G

<400>  101
gcaggctca                                                              9


<210>  102
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (5)..(5)
<223>  KCNH2; G1877C

<400>  102
cccgccagc                                                              9


<210>  103
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (6)..(6)
<223>  KCNH2; G1911C

<400>  103
tcagacaag                                                              9


<210>  104
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (5)..(5)
<223>  KCNH2; G1930T

<400>  104
ctgcttcat                                                              9


<210>  105
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (5)..(5)
<223>  KCNH2; T1967G

<400>  105
atctgcggc                                                              9


<210>  106
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (4)..(4)
<223>  KCNH2; C1979T

<400>  106
tgttggcca                                                              9


<210>  107
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (5)..(5)
<223>  KCNH2; G2087C

<400>  107
cagcccctc                                                              9


<210>  108
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  KCNH2; 2164-2181dup

<400>  108
tgacgagtg                                                              9


<210>  109
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  KCNH2; 2231delG

<400>  109
cttccaggg                                                              9


<210>  110
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (5)..(5)
<223>  KCNH5; G2398+3A>G

<400>  110
gggtgtggg                                                              9


<210>  111
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (5)..(5)
<223>  KCNH2; G2398+3A>T

<400>  111
gggtttggg                                                              9


<210>  112
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (5)..(5)
<223>  KCNH2; G2398T

<400>  112
cctgtgtat                                                              9


<210>  113
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (5)..(5)
<223>  KCNH2; T2452C

<400>  113
aagccgaac                                                              9


<210>  114
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (5)..(5)
<223>  KCNH2; A2494T

<400>  114
tggctagtc                                                              9


<210>  115
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (4)..(4)
<223>  KCNH2; A2581C

<400>  115
ttccacctg                                                              9


<210>  116
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  KCNH2; 2638-2648del

<400>  116
gggtgcaac                                                              9


<210>  117
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  KCNH2; 2676-2682del

<400>  117
tccgacgga                                                              9


<210>  118
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  KCNH2; 2732-2766del

<400>  118
ccggccggg                                                              9


<210>  119
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  KCNH2; 2738-2739insCGGGC

<400>  119
ggcgggccg                                                              9


<210>  120
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  KCNH2; 2775delG

<400>  120
ggggccgtg                                                              9


<210>  121
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (5)..(5)
<223>  KCNH2; G2781A

<400>  121
cgtgagggg                                                              9


<210>  122
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  KCNH2; 2895-2905del

<400>  122
cccgggtgg                                                              9


<210>  123
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (5)..(5)
<223>  KCNH2; C2903T

<400>  123
ccgctgggt                                                              9


<210>  124
<211>  11
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (6)..(6)
<223>  KCNH2; C3045A

<400>  124
cgatgacccg c                                                          11


<210>  125
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  KCNH2; 3093-3106del

<400>  125
cccggggcg                                                              9


<210>  126
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (4)..(8)
<223>  KCNH2; 3093-3099del/insTTCGC

<400>  126
gggttcgcc                                                              9


<210>  127
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  KCNH2; 3099delG

<400>  127
ggcgccccg                                                              9


<210>  128
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  KCNH2; 3100delC

<400>  128
gcggcccgg                                                              9


<210>  129
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  KCNH2; 3154delC

<400>  129
caggtggag                                                              9


<210>  130
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (4)..(4)
<223>  KCNH2; 3304InsC

<400>  130
ccccaccct                                                              9


<210>  131
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  KCNH2; 3397-3398del

<400>  131
cccacgacg                                                              9


<210>  132
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (4)..(4)
<223>  KCNH2; C3457T

<400>  132
ctgtacaga                                                              9


<210>  133
<211>  10
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (6)..(6)
<223>  SNC5A; C1238A

<400>  133
ggtcgaaatg                                                            10


<210>  134
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (5)..(5)
<223>  SNC5A; G1237A

<400>  134
ggtcacaat                                                              9


<210>  135
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (5)..(5)
<223>  KCNH2; C1717G

<400>  135
tgccgaggg                                                              9


<210>  136
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (5)..(5)
<223>  SNC5A; G1735A

<400>  136
tcccagaac                                                              9


<210>  137
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (5)..(5)
<223>  SNC5A; G2066A

<400>  137
aaccatctc                                                              9


<210>  138
<211>  10
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (6)..(6)
<223>  SNC5A; T4493C

<400>  138
tgccacgaag                                                            10


<210>  139
<211>  11
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (7)..(7)
<223>  SNC5A; G4877C

<400>  139
tcttcccagt c                                                          11


<210>  140
<211>  10
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (5)..(5)
<223>  SNC5A; C4930T

<400>  140
gatctgcacg                                                            10


<210>  141
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (5)..(5)
<223>  SNC5A;  A4978G

<400>  141
caacgtcgg                                                              9


<210>  142
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (5)..(5)
<223>  SNC5A; A5300G

<400>  142
atgtgcatt                                                              9


<210>  143
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (5)..(5)
<223>  SNC5A; G5360A

<400>  143
caccaagcc                                                              9


<210>  144
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (5)..(5)
<223>  SNC5A; A5369G

<400>  144
gagggcgac                                                              9


<210>  145
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (5)..(5)
<223>  SNC5A; G5738A

<400>  145
ttccacagg                                                              9


<210>  146
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (5)..(5)
<223>  KCNE1; G107A

<400>  146
ccccacagc                                                              9


<210>  147
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (5)..(5)
<223>  KCNE2; T158G

<400>  147
ggatgcttc                                                              9


<210>  148
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (4)..(4)
<223>  KCNE2; A166G

<220>
<221>  mutation
<222>  (7)..(9)
<223>  KCNE2; 169InsATG

<400>  148
gtggtgatg                                                              9


<210>  149
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  KCNE2; 156-161del

<400>  149
ctgtaggtg                                                              9


<210>  150
<211>  21
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  KCNQ1; Primer ID KV11.1

<400>  150
cactcaaggc cgagcctgcc t                                               21


<210>  151
<211>  20
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  KCNQ1; Primer ID KV5NA

<400>  151
gccccacacc atctccttcg                                                 20


<210>  152
<211>  18
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  KCNQ1; Primer ID KV6NI

<400>  152
taccctaacc cgggccac                                                   18


<210>  153
<211>  20
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  KCNQ1; Primer ID KVDFn

<400>  153
gaggagaagt gatgcgtgtc                                                 20


<210>  154
<211>  20
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  KCNQ1; Primer ID KVDRn

<400>  154
ggcaggacct gggcaccctc                                                 20


<210>  155
<211>  20
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  KCNQ1; Primer ID KV1A1F

<400>  155
cttcgctgca gctcccggtg                                                 20


<210>  156
<211>  20
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  KCNQ1; Primer ID KV1A2R

<400>  156
acgcgcgggt ctaggctcac                                                 20


<210>  157
<211>  21
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  KCNQ1; Primer ID KK2F

<400>  157
gactgccgtg tccctgtctt g                                               21


<210>  158
<211>  21
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  KCNQ1; Primer ID KK2R

<400>  158
gccatgcctt cagatgctac g                                               21


<210>  159
<211>  20
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  KCNQ1; Primer ID KK12Rn

<400>  159
ctgagggcag gaaggctcag                                                 20


<210>  160
<211>  20
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  KCNQ1; Primer ID KK14F1

<400>  160
ctgtctgtcc cacagacgac                                                 20


<210>  161
<211>  20
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  KCNQ1; Primer ID KK14Rn

<400>  161
ctgggcccag agtaactgac                                                 20


<210>  162
<211>  21
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  KCNQ1; Primer ID KK15Fn

<400>  162
cggcccaccc cagcacttgg c                                               21


<210>  163
<211>  21
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  KCNQ1; Primer ID KK15Rn

<400>  163
gaaccaccgc aggccggcgc g                                               21


<210>  164
<211>  18
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  KCNQ1; Primer ID KK16Fn

<400>  164
cgtctgcctt tgtccccg                                                   18


<210>  165
<211>  18
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  KCNQ1; Primer ID KK16Rn

<400>  165
cactcttggc ctcccctc                                                   18


<210>  166
<211>  19
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  KCNE1; Primer ID MINK F

<400>  166
ctgcagcagt ggaccctta                                                  19


<210>  167
<211>  20
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  KCNE1; Primer ID MINK 1R

<400>  167
agcttcttgg agcggatgta                                                 20


<210>  168
<211>  20
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  KCNE1; Primer ID MINK 2F

<400>  168
gtcctcatgg tactgggatt                                                 20


<210>  169
<211>  19
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  KCNE1; Primer ID MINK R

<400>  169
tttagccagt ggtggggtt                                                  19


<210>  170
<211>  24
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  KCNE2; Primer ID MINK2-F2

<400>  170
ccgttttcct aaccttgttc gcct                                            24


<210>  171
<211>  26
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  KCNE2; Primer ID MINK2-R2

<400>  171
gccacgatga tgaaagagaa cattcc                                          26


<210>  172
<211>  23
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  KCNE2; Primer ID MINK2-F3

<400>  172
gtcatcctgt acctcatggt gat                                             23


<210>  173
<211>  24
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  KCNE2; Primer ID MINK2-R3

<400>  173
tggacgtcag atgttagctt ggtg                                            24


<210>  174
<211>  21
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  SNC5A; Primer ID SCN2.1Fnew

<400>  174
ccctgctctc tgtccctggg c                                               21


<210>  175
<211>  20
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  SNC5A; Primer ID SCN2.1Rnew

<400>  175
gcagcccctc tcggctctcc                                                 20


<210>  176
<211>  21
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  SNC5A; Primer ID SCN2.2Fnew

<400>  176
catggcagag aagcaagccc g                                               21


<210>  177
<211>  22
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  SNC5A; Primer ID SCN6Fnew

<400>  177
cctcctctga ctgtgtgtct cc                                              22


<210>  178
<211>  21
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  SNC5A; Primer ID SCN10Fnew

<400>  178
ccagtgaggg tgacctctgc c                                               21


<210>  179
<211>  21
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  SNC5A; Primer ID SCN10Rnew

<400>  179
ggcttagagg ctcctcggtg g                                               21


<210>  180
<211>  21
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  SNC5A; Primer ID SCN16F

<400>  180
gagccagaga ccttcacaag g                                               21


<210>  181
<211>  24
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  SNC5A; Primer ID

<220>
<221>  misc_feature
<223>  SNC5A; Primer ID SCN17.1Fnew

<400>  181
gcttggcatg gtgcagtgcc ttgg                                            24


<210>  182
<211>  22
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  SNC5A; Primer ID SCN17.1Rnew

<400>  182
gaggcacctt ctccgtctct gg                                              22


<210>  183
<211>  24
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  SNC5A; Primer ID SCN20Fnew

<400>  183
cattagatgt gggcattcac aggc                                            24


<210>  184
<211>  21
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  SNC5A; Primer ID SCN20Rnew

<400>  184
ccagccgtcc ctgccacaac c                                               21


<210>  185
<211>  21
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  SNC5A; Primer ID SCN21Fnew

<400>  185
ggtccaggct tcatgtccac c                                               21


<210>  186
<211>  22
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  SNC5A; Primer ID

<220>
<221>  misc_feature
<223>  SNC5A; Primer ID SCN21Rnew

<400>  186
ggcaatgggt ttctccttcc tg                                              22


<210>  187
<211>  22
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  SNC5A; Primer ID SCN22Fnew

<400>  187
ggggagctgt tcccatcctc cc                                              22


<210>  188
<211>  21
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  SNC5A; Primer ID SCN22Rnew

<400>  188
cgcctcccac tccctggtgg g                                               21


<210>  189
<211>  23
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  SNC5A; Primer ID SCN23.1F

<400>  189
ttgaaaagga aatgtgctct ggg                                             23


<210>  190
<211>  22
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  SNC5A; Primer ID SCN23.1R

<400>  190
ttgttcacga tggtgtagtt ca                                              22


<210>  191
<211>  21
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  SNC5A; Primer ID SCN23.2F

<400>  191
ccagacagag ggagacttgc c                                               21


<210>  192
<211>  22
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  SNC5A; Primer ID SCN25Fnew

<400>  192
cccagcctgt ctgatctccc tg                                              22


<210>  193
<211>  21
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  SNC5A; Primer ID SCN25Rnew

<400>  193
ccaccctacc cagcccagtg g                                               21


<210>  194
<211>  20
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  KCNH2; Primer ID HM1F

<400>  194
catgggctca ggatgccggt                                                 20


<210>  195
<211>  22
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  KCNH2; Primer ID KCNH2-1R

<400>  195
cattgactcg cacttgccga cg                                              22


<210>  196
<211>  20
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  KCNH2; Primer ID H2F

<400>  196
cgctcacgcg cactctcctc                                                 20


<210>  197
<211>  20
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  KCNH2; Primer ID KH2R

<400>  197
ttgaccccgc ccctggtcgt                                                 20


<210>  198
<211>  21
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  KCNH2; Primer ID H3F

<400>  198
ccactgagtg ggtgccaagg g                                               21


<210>  199
<211>  21
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  KCNH2; Primer ID H3R

<400>  199
gagaccacga acccctgagc c                                               21


<210>  200
<211>  21
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  KCNH2; Primer ID H4.1F

<400>  200
cccacgacca cgtgcctctc c                                               21


<210>  201
<211>  18
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  KCNH2; Primer ID H8R

<400>  201
gcctgccacc cactggcc                                                   18


<210>  202
<211>  22
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  KCNH2; Primer ID KH9F

<400>  202
atggtggagt agagtgtggg tt                                              22


<210>  203
<211>  21
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  KCNH2; Primer ID

<220>
<221>  misc_feature
<223>  KCNH2; Primer ID KH9R

<400>  203
agaaggctcg cacctcttga g                                               21


<210>  204
<211>  21
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  KCNH2; Primer ID KH10F

<400>  204
gagaaggtgc ctgctgcctg g                                               21


<210>  205
<211>  21
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  KCNH2; Primer ID KH10R

<400>  205
acagctggaa gcaggaggat g                                               21


<210>  206
<211>  22
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  KCNH2; Primer ID H11F

<400>  206
ggcaggagag cactgaaagg gc                                              22


<210>  207
<211>  22
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  KCNH2; Primer ID H11R

<400>  207
ggtaaagcag acacggccca cc                                              22


<210>  208
<211>  22
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  KCNH2; Primer ID H12A F

<400>  208
gttctcctcc cctctctgag gc                                              22


<210>  209
<211>  21
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  KCNH2; Primer ID H12B R

<400>  209
gggtagacgc accaccgctg c                                               21


<210>  210
<211>  21
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  KCNH2; Primer ID H13F

<400>  210
gcagcggtgg tgcgtctacc c                                               21


<210>  211
<211>  22
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  KCNH2; Primer ID H13R

<400>  211
gacctggacc agactccagg gc                                              22


<210>  212
<211>  20
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  KCNH2; Primer ID H14R

<400>  212
gggtacatcg aggaagcagg                                                 20


