                         SEQUENCE LISTING

<110>  Davis,  S. Christopher
       Fox , Richard  J.
       Gavrilovic, Vesna
       Huisman, Gjalt  W.
       Mundorff, Emily C.
       Newman,  Lisa  M.
 
<120>  Improved Halohydrin Dehalogenases and Related Polynucleotides

<130>  0353.510WO

<150>  11/266,747
<151>  2005-11-02

<150>  11/067,323
<151>  2005-02-23

<160>  2848  

<170>  PatentIn version 3.3

<210>  1
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(765)

<400>  1
atg agc acc gct atc gtc acc aac gtc aaa cat ttt ggt ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg ccg tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta ggg gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa          765
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  3
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(765)

<400>  3
atg agc acc gct atc gtc acc aac gtc aaa cat ttt ggt ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct cta agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aac cag aaa gat gaa ctg gaa gct ttg cct gaa acc tac      144
Glu Ser Phe Asn Gln Lys Asp Glu Leu Glu Ala Leu Pro Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agg gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Arg Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtg gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg ccg tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt cct atg ata gaa cgt tgg ccc ggc atg ccc gaa taa          765
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  4
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  4

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Asn Gln Lys Asp Glu Leu Glu Ala Leu Pro Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Arg Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  5
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(765)

<400>  5
atg agc acc gct atc gtc acc aac gtc aaa cat ttt ggt ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa act ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Thr Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg ccg tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa          765
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  6
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  6

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Thr Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  7
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(765)

<400>  7
atg agc acc gct atc gtc acc aac gtc aaa cat ttt ggt ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agc ctg agc gaa gct ggt cat acc gtc act tgc cat gat       96
Ser Ala Leu Ser Leu Ser Glu Ala Gly His Thr Val Thr Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg ccg tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa          765
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  8
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  8

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Ser Leu Ser Glu Ala Gly His Thr Val Thr Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  9
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(765)

<400>  9
atg acc gcc gct atc gtc acc aac gtc aaa cat ttt ggt ggt atg ggt       48
Met Thr Ala Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc act tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Thr Cys His Asp         
            20                  25                  30                  

gaa agg ttg aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Arg Leu Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aat cca atg agc gaa cag gag cca gct gaa ctg atc gaa      192
Pro Gln Leu Asn Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg ccg tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gag cgt tgg ccc ggc atg ccc gaa taa          765
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  10
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  10

Met Thr Ala Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Thr Cys His Asp 
            20                  25                  30          


Glu Arg Leu Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Asn Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  11
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(765)

<400>  11
atg agc ccc gct atc gtc acc aac atc aaa cat ttt agc ggt atg tgt       48
Met Ser Pro Ala Ile Val Thr Asn Ile Lys His Phe Ser Gly Met Cys         
1               5                   10                  15              

cgc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Arg Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg ccg tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa          765
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  12
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  12

Met Ser Pro Ala Ile Val Thr Asn Ile Lys His Phe Ser Gly Met Cys 
1               5                   10                  15      


Arg Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  13
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(765)

<400>  13
atg agc acc gct atc gac acc aac gtc aaa cat ttt ggt agt aag ggt       48
Met Ser Thr Ala Ile Asp Thr Asn Val Lys His Phe Gly Ser Lys Gly         
1               5                   10                  15              

acc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Thr Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gat ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Asp Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac aga ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg agt act ccg ttc ggg ccg tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ser Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag cct tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cgg cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa          765
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  14
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  14

Met Ser Thr Ala Ile Asp Thr Asn Val Lys His Phe Gly Ser Lys Gly 
1               5                   10                  15      


Thr Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Asp Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ser Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  15
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(765)

<400>  15
atg agc acc gct atc gtc acc aac gtc aaa cat ttt ggt ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ctc ggg ccg tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Leu Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa          765
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  16
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  16

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Leu Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  17
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(756)

<400>  17
atg agc acc gct atc gtc acc aac gtc aaa cat ttt ggt ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg ccg tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag ggg ttt ttt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Gly Phe Phe Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg cccgtataa            765
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met                         
                245                 250                                 


<210>  18
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  18

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Gly Phe Phe Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met 
                245                 250         


<210>  19
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(765)

<400>  19
atg agc ccc gct atc gtc acc aac gtc aaa cat ttt ggt ggt atg ggt       48
Met Ser Pro Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg ccg tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa          765
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  20
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  20

Met Ser Pro Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  21
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(765)

<400>  21
atg agc acc gct atc gtc acc aac gtc aaa cat ttt ggt ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aac cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Asn Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg ccg tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc gtg ccc gaa taa          765
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Val Pro Glu                 
                245                 250                                 


<210>  22
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  22

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Asn Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Val Pro Glu 
                245                 250                 


<210>  23
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(765)

<400>  23
atg agc acc gct atc gtc acc aac gtc aaa cat ttt ggt ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg ccg tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac atg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Met Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa          765
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  24
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  24

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Met Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  25
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(765)

<400>  25
atg agc acc gct atc gtc acc aac gtc aaa cat ttt ggt ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ctc ggg ccg tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Leu Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa          765
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  26
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  26

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Leu Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  27
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(756)

<400>  27
atg agc ccc gct atc gtc acc aac gtc aaa cat ttt ggt ggt atg ggt       48
Met Ser Pro Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg ccg tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg cccgaataa            765
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met                         
                245                 250                                 


<210>  28
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  28

Met Ser Pro Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met 
                245                 250         


<210>  29
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(765)

<400>  29
atg agc acc gtt atc gtc acc aac gtc aaa cat ttt ggt ggt atg ggt       48
Met Ser Thr Val Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gcc ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa act tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg ccg tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa          765
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  30
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  30

Met Ser Thr Val Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  31
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(765)

<400>  31
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa          765
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  32
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  32

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  33
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(765)

<400>  33
atg agc ccc gct atc gtc act aac gtc aaa cat ttt ggt ggt atg ggt       48
Met Ser Pro Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

acc gct ctg agg ctg agc gaa gct ggt caa acc gtc gct tgc cat gat       96
Thr Ala Leu Arg Leu Ser Glu Ala Gly Gln Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg ccg tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa          765
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  34
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  34

Met Ser Pro Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Thr Ala Leu Arg Leu Ser Glu Ala Gly Gln Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  35
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(765)

<400>  35
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gac ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Asp Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa aac      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asn         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aaa cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg cca tgg aaa gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttc ctg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc ata ata gaa cgt tgg ccc ggc atg ccc gaa taa          765
Gly Gly Phe Pro Ile Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  36
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  36

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Asp Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asn 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ile Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  37
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(765)

<400>  37
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc caa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Gln Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct ccg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Pro Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt tct cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Ser Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat gtg ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Val Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttc ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa          765
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  38
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  38

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Gln Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Pro Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Ser Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Val Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  39
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(765)

<400>  39
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aaa cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg cca tgg aaa gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttc ctg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc ata ata gaa cgt tgg ccc ggc atg ccc gaa taa          765
Gly Gly Phe Pro Ile Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  40
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  40

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ile Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  41
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(765)

<400>  41
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gac ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Asp Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa gac      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aaa cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg cca tgg aaa gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttc ctg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc att ata gaa cgt tgg ccc ggc atg ccc gaa taa          765
Gly Gly Phe Pro Ile Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  42
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  42

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Asp Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ile Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  43
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  43
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg aaa ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

ggt agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa gcc tac      144
Gly Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct cca caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Pro Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg ttc tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gct ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  44
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  44

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Gly Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Pro Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  45
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(765)

<400>  45
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gct ccg ttc ggg cca tgg aaa gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttc ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa          765
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  46
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  46

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  47
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(765)

<400>  47
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc caa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Gln Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg cca tgg aag gag cta tcg agt      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Ser         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt tct cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Ser Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa          765
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  48
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  48

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Gln Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Ser 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Ser Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  49
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(765)

<400>  49
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc cag gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Gln Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa          765
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  50
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  50

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Gln Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  51
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(765)

<400>  51
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc cag gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Gln Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct ctg gcg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gct ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa          765
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  52
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  52

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Gln Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  53
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(765)

<400>  53
atg acc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Thr Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt tct cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Ser Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa          765
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  54
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  54

Met Thr Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Ser Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  55
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(765)

<400>  55
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa aac      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asn         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aaa cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg cca tgg aaa gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttc ctg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc ata ata gaa cgt tgg ccc ggc atg ccc gaa taa          765
Gly Gly Phe Pro Ile Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  56
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  56

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asn 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ile Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  57
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(765)

<400>  57
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct agt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Ser Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa          765
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  58
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  58

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Ser Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  59
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(765)

<400>  59
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct gcg cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Ala His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa          765
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  60
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  60

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Ala His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  61
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(765)

<400>  61
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg cca tgg aaa gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt gct cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac cca act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttc ctg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc att atc gaa cgt tgg ccc ggc atg ccc gaa taa          765
Gly Gly Phe Pro Ile Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  62
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  62

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ile Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  63
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(765)

<400>  63
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg cca tgg aaa gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt gct cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac cca act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttc ctg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc att atc gaa cgt tgg ccc ggc atg ccc gaa taa          765
Gly Gly Phe Pro Ile Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  64
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  64

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ile Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  65
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(765)

<400>  65
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg cca tgg aaa gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt gct cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac cca act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttc ctg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc att atc gaa cgt tgg ccc ggc atg ccc gaa taa          765
Gly Gly Phe Pro Ile Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  66
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  66

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ile Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  67
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(765)

<400>  67
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg ggg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Gly Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cac aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gat cca gct gac ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Asp Pro Ala Asp Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aaa cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg cca tgg aaa gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat gtg ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Val Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc att atc gaa cgt tgg ccc ggc atg ccc gaa taa          765
Gly Gly Phe Pro Ile Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  68
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  68

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Gly Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Asp Pro Ala Asp Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Val Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ile Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  69
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(765)

<400>  69
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc cag gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Gln Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gct ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt tcc cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Ser Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa          765
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  70
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  70

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Gln Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Ser Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  71
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(765)

<400>  71
atg agc acc gct atc gtc acc aac gtc aaa cat ttt ggt ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg ccg tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa          765
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  72
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  72

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  73
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(765)

<400>  73
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agt gct ctg agg ctg tcg gag gct ggt cac acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gag gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gga ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Gly Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa          765
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  74
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  74

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Gly Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  75
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(765)

<400>  75
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tat cgt ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gaa cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa          765
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  76
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  76

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  77
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(765)

<400>  77
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg cca tgg aaa gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttc ctg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc att atc gaa cgt tgg ccc ggc atg ccc gaa taa          765
Gly Gly Phe Pro Ile Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  78
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  78

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ile Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  79
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(765)

<400>  79
atg acc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Thr Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc cag gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Gln Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gct ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa          765
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  80
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  80

Met Thr Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Gln Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  81
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(765)

<400>  81
atg acc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Thr Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc cag gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Gln Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gct ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt tcc cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Ser Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa          765
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  82
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  82

Met Thr Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Gln Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Ser Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  83
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(765)

<400>  83
atg acc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Thr Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc cag gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Gln Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gct ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa          765
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  84
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  84

Met Thr Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Gln Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  85
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(765)

<400>  85
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct tca gaa ttt cag cca atc gat aaa tac gcc gtc gaa gat      288
Ile Phe Ala Ser Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tat cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa          765
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  86
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  86

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Ser Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  87
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(765)

<400>  87
atg agc acc gct atc gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tat ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa          765
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  88
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  88

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  89
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(765)

<400>  89
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa ggt ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Gly Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct agt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Ser Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa          765
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  90
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  90

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Gly Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Ser Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  91
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(765)

<400>  91
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct agt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Ser Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa          765
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  92
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  92

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Ser Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  93
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(765)

<400>  93
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Leu Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct agt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Ser Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc acg ata gaa cgt tgg ccc ggc atg ccc gaa taa          765
Gly Gly Phe Pro Thr Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  94
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  94

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Ser Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Thr Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  95
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(765)

<400>  95
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Leu Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct agt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Ser Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc acg ata gaa cgt tgg ccc ggc atg ccc gaa taa          765
Gly Gly Phe Pro Thr Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  96
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  96

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Ser Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Thr Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  97
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(765)

<400>  97
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cgt tgg ccc ggc atg ccc gaa taa          765
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  98
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  98

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  99
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(765)

<400>  99
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cgt tgg ccc ggc atg ccc gaa taa          765
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  100
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  100

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  101
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  101
atg agc acc gct atc gtc acc aac gtc aaa cat ttt ggt ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc tct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ser Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aga cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Arg Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cgg cca atc gat aaa tac gct gtc caa aat      288
Ile Phe Ala Pro Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Gln Asn         
                85                  90                  95              

tac agg cga gct gtc gaa gct ctg cag atc atg cca ttt gct gta gag      336
Tyr Arg Arg Ala Val Glu Ala Leu Gln Ile Met Pro Phe Ala Val Glu         
            100                 105                 110                 

aat gct gtg act tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Thr Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcc gct act ccg ttc ggg ccg tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  102
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  102

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ser Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Arg Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Gln Asn 
                85                  90                  95      


Tyr Arg Arg Ala Val Glu Ala Leu Gln Ile Met Pro Phe Ala Val Glu 
            100                 105                 110         


Asn Ala Val Thr Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  103
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  103
atg atc acc gcg gcc aac act aac ttc aaa ctg agg ggt ggt atg ggt       48
Met Ile Thr Ala Ala Asn Thr Asn Phe Lys Leu Arg Gly Gly Met Gly         
1               5                   10                  15              

agc gtt ccg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Val Pro Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cgt aag acg ggt cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Thr Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg ccg tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  104
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  104

Met Ile Thr Ala Ala Asn Thr Asn Phe Lys Leu Arg Gly Gly Met Gly 
1               5                   10                  15      


Ser Val Pro Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Thr Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  105
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  105
atg agc aca gac atc gtc acc aac gtc aaa cat ttt gga ggt acg ggt       48
Met Ser Thr Asp Ile Val Thr Asn Val Lys His Phe Gly Gly Thr Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc ggc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Gly Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac cgt ggt act gat gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Thr Asp Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat agc ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct cgt gat tat ctg act gtg cag gtg gtg tgg ctg ccg      720
Ala Ser Gly Ser Arg Asp Tyr Leu Thr Val Gln Val Val Trp Leu Pro         
225                 230                 235                 240         

ggc ggc ttt ccg atg ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  106
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  106

Met Ser Thr Asp Ile Val Thr Asn Val Lys His Phe Gly Gly Thr Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Gly Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Thr Asp Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Arg Asp Tyr Leu Thr Val Gln Val Val Trp Leu Pro 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  107
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  107
atg agc acg gac ggc gac acc acg gtc aaa cat ttt gga ggt aaa ggt       48
Met Ser Thr Asp Gly Asp Thr Thr Val Lys His Phe Gly Gly Lys Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cac aaa gat gat ctg gaa gct ttt gct gaa ccg tac      144
Glu Ser Phe Lys His Lys Asp Asp Leu Glu Ala Phe Ala Glu Pro Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc cag aac      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Gln Asn         
                85                  90                  95              

tac cgt ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act cag aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ctg act gtg cag gtg gtg tgg ctg acc      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Val Gln Val Val Trp Leu Thr         
225                 230                 235                 240         

ggc ggg ttt ccg atg ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  108
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  108

Met Ser Thr Asp Gly Asp Thr Thr Val Lys His Phe Gly Gly Lys Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Asp Leu Glu Ala Phe Ala Glu Pro Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Gln Asn 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Val Gln Val Val Trp Leu Thr 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  109
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  109
atg agc acc gca atc gtc acc acg gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Thr Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

aac cct gtg agg ctt agg gaa gct ggt cat agc gtc act tgc cat gat       96
Asn Pro Val Arg Leu Arg Glu Ala Gly His Ser Val Thr Cys His Asp         
            20                  25                  30                  

aaa agc ttt aaa cag aaa gct gaa ctg gaa gct ttt gct gaa acc tgc      144
Lys Ser Phe Lys Gln Lys Ala Glu Leu Glu Ala Phe Ala Glu Thr Cys         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat agc ccg tgt ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Cys Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ctg act gtg cag gtg gtg tgg ctg acc      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Val Gln Val Val Trp Leu Thr         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccg ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  110
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  110

Met Ser Thr Ala Ile Val Thr Thr Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Asn Pro Val Arg Leu Arg Glu Ala Gly His Ser Val Thr Cys His Asp 
            20                  25                  30          


Lys Ser Phe Lys Gln Lys Ala Glu Leu Glu Ala Phe Ala Glu Thr Cys 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Cys Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Val Gln Val Val Trp Leu Thr 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  111
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  111
atg agc acc gac atc gtc acc aac gtc aaa cat ttt gga ggt aaa ggt       48
Met Ser Thr Asp Ile Val Thr Asn Val Lys His Phe Gly Gly Lys Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt ctg agc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly Leu Ser Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa ccg tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Pro Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac cgt ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg cca tgg aag gaa cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct tta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg gtg tgg ctg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Val Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt cgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Met Ile Glu Arg Arg Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  112
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  112

Met Ser Thr Asp Ile Val Thr Asn Val Lys His Phe Gly Gly Lys Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly Leu Ser Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Pro Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Val Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Arg Pro Gly Met Pro Glu 
                245                 250                 


<210>  113
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  113
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt ctg agc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly Leu Ser Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gat gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Asp Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg atg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Met Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg gtg tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Val Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  114
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  114

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly Leu Ser Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Asp Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Met Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Val Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  115
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  115
atg agc acc gtc atc gtc acc acg gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Val Ile Val Thr Thr Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa ccg tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Pro Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa aac      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asn         
                85                  90                  95              

tac agg ggt gct gat gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Asp Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cgt atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly Arg Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ctg ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Leu Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac tcg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Ser Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act gtg cag gtg gtg tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Val Gln Val Val Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  116
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  116

Met Ser Thr Val Ile Val Thr Thr Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Pro Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asn 
                85                  90                  95      


Tyr Arg Gly Ala Asp Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly Arg Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Leu Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Ser Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Val Gln Val Val Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  117
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  117
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

acc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Thr Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc aat aaa tac gct gtc caa aat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asn Lys Tyr Ala Val Gln Asn         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct ata gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Ile Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg tgt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Cys Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  118
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  118

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Thr Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asn Lys Tyr Ala Val Gln Asn 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Ile Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Cys Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  119
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  119
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt ctg acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly Leu Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gat ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Asp Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gat cca gct gac ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Asp Pro Ala Asp Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa aac      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asn         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg cca tgg aaa gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc att atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Ile Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  120
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  120

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly Leu Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Asp Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Asp Pro Ala Asp Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asn 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ile Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  121
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  121
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gat ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Asp Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa aac      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asn         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aaa cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg tct act ccg ttc ggg cca tgg aaa gag cta tcg act      432
Phe Ile Thr Ser Ser Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttc ctg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc cta ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Leu Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  122
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  122

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Asp Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asn 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ser Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Leu Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  123
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  123
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gat ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Asp Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gac ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Asp Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa aac      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asn         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg cca tgg aaa gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc att atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Ile Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  124
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  124

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Asp Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Asp Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asn 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ile Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  125
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  125
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gat ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Asp Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gac ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Asp Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa aac      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asn         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg cca tgg aaa gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc att atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Ile Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  126
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  126

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Asp Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Asp Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asn 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ile Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  127
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  127
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca caa ttt cag cca gtc gaa aaa tac gca gtc gaa gat      288
Ile Phe Ala Pro Gln Phe Gln Pro Val Glu Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aaa cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  128
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  128

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Gln Phe Gln Pro Val Glu Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  129
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  129
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca caa ttt cag cca gtg gac aaa tac tca gtc gaa gat      288
Ile Phe Ala Pro Gln Phe Gln Pro Val Asp Lys Tyr Ser Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  130
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  130

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Gln Phe Gln Pro Val Asp Lys Tyr Ser Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  131
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  131
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca caa ttt cag cca gtc gac aaa tac gca gtc gaa gat      288
Ile Phe Ala Pro Gln Phe Gln Pro Val Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg tta ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Leu Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtg ata gaa cgt tgg cct ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  132
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  132

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Gln Phe Gln Pro Val Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Leu Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  133
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  133
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gat cca gct gac ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Asp Pro Ala Asp Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc caa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Gln Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gct ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct agt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Ser Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  134
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  134

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Asp Pro Ala Asp Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Gln Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Ser Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  135
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  135
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc caa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Gln Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct agt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Ser Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  136
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  136

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Gln Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Ser Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  137
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  137
atg agc gcc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Ala Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc caa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Gln Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt tcc cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Ser Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  138
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  138

Met Ser Ala Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Gln Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Ser Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  139
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  139
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc caa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Gln Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct agt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Ser Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc ata ccc gaa taa tga      768
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Ile Pro Glu                 
                245                 250                                 


<210>  140
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  140

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Gln Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Ser Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Ile Pro Glu 
                245                 250                 


<210>  141
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  141
atg agc acc gct atc gtc acc aac ttc aca cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Phe Thr His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac aca tcg gct cga gct ggg gct agt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Ser Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  142
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  142

Met Ser Thr Ala Ile Val Thr Asn Phe Thr His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Ser Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  143
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  143
atg agc acc gct atc gtc acc aac ttc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Phe Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc atc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ile Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc cag gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Gln Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct acc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt ccc cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Pro Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg cct aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act gac cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Asp Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  144
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  144

Met Ser Thr Ala Ile Val Thr Asn Phe Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ile Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Gln Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Pro Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Asp Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  145
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  145
atg agc acg gct atc gtg acc aac ttc aaa cat ttt gga ggc atg gac       48
Met Ser Thr Ala Ile Val Thr Asn Phe Lys His Phe Gly Gly Met Asp         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa caa gaa cca tct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ser Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac tct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ser Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gcc cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gcg act ccc caa atg aag aag cga aag tcg ggg cac att atc      384
Asn Ala Ala Thr Pro Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct agt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Ser Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gaa ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg gct ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Ala Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtg ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  146
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  146

Met Ser Thr Ala Ile Val Thr Asn Phe Lys His Phe Gly Gly Met Asp 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ser Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ser Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Ala Thr Pro Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Ser Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Ala Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  147
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  147
atg agc acc gct atc gtc acc act ttc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Thr Phe Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gtt ctc agg ctg agc gaa ggt ggt cat acc gtc gct tgc cat gat       96
Ser Val Leu Arg Leu Ser Glu Gly Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct agt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Ser Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  148
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  148

Met Ser Thr Ala Ile Val Thr Thr Phe Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Val Leu Arg Leu Ser Glu Gly Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Ser Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  149
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  149
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Leu Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct ccg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Pro Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct agt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Ser Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc acg ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Thr Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  150
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  150

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Pro Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Ser Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Thr Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  151
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  151
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg aag ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa gcc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Leu Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct agt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Ser Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag ata aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc acg ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Thr Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  152
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  152

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Ser Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Thr Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  153
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  153
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg aag ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc ttt      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Phe         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Leu Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag atg cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Met Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct agt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Ser Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc acg ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Thr Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  154
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  154

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Phe 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Met Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Ser Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Thr Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  155
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  155
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc aaa cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aac tct gtg gct tcc caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ser Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga ctc ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc acg ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Thr Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  156
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  156

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ser Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Thr Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  157
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  157
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc aaa cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aac gct gtg gct ccc caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Pro Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct tct ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ser Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt act cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att gat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asp Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc acg ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Thr Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  158
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  158

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Pro Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ser Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asp Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Thr Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  159
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  159
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc aaa cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct tct ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ser Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att gat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asp Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  160
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  160

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ser Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asp Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  161
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  161
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc aaa cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aac gct gtg gct cac caa atg aag agg cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala His Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct agt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Ser Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att gat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asp Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc cct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Pro Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc acg ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Thr Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  162
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  162

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala His Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Ser Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asp Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Pro Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Thr Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  163
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  163
atg agc act gcg att gtt act aac gtc aaa cat ttc ggt ggt atg ggg       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agt gcg ctg cgc ctg tcg gag gcc ggt cat aca gta gcg tgt cac gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agt ttc aaa caa aag gac gaa ttg gaa gcc ttt gcg gaa act tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa ccg atg tca gaa cag gag cca gcg gag tta att gag      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gcg gtc acc agt gcc ttc ggc cag gtg gat gtc ctg gtt agc aac gac      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct ctg gaa ttc cgt ccg att gac aag tat gcc gtc gaa gac      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac cgt ggt gcg gta gaa gca ctg cag atc cgc ccg ttc gcg ttg gtt      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gcc gta gct agt caa atg aaa aaa cgt aaa tca ggt cat att atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc att act agc gcg agc ccg ttt ggt cca tgg aag gag ctg tcg act      432
Phe Ile Thr Ser Ala Ser Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tat agt agt gcg cgc gcc ggg gcc tcc acc ttg gct aac gca ctg agt      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aaa gaa tta ggt gag tat aat atc cct gtt ttc gcc att ggg cca aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tat ctg cac tca gaa gat agc cca tac tat tac cca acg gaa ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag atc aac cct gaa cat gtg gcg cat gtt aaa aaa gta aca gcc tta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cgt ctg ggt act caa aaa gaa ctt ggc gag ctg gtt gcg ttt ctc      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gct tct ggt agc tgc gat tac ttg acc ggc caa gtc ttc tgg tta gcc      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggt ggc ttt ccg act att gag cgc tgg cca ggt atg ccg gaa taa tga      768
Gly Gly Phe Pro Thr Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  164
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  164

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ser Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Thr Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  165
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  165
atg agc act gcg att gtt act aac gtc aaa cat ttc ggt ggt atg ggg       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agt gcg ctg cgc ctg tcg gag gcc ggt cat aca gta gcg tgt cac gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agt ttc aaa caa aag gac gaa ttg gaa gcc ttt gcg gaa act tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa ccg atg tca gaa cag gag cca gcg gag tta att gag      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gcg gtc acc agt gcc ttc ggc cag gtg gat gtc ctg gtt agc aac gac      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct ctg gaa ttc cgt ccg att gac aag tat gcc gtc gaa gac      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac cgt ggt gcg gta gaa gca ctg cag atc aag ccg ttc gcg ttg gtt      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gcc gta gct agt caa atg aaa aaa cgt aaa tca ggt cat att atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc att act agc gcg gct ccg ttt ggt cca tgg aag gag ctg tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tat agt agt gcg cgc gcc ggg gcc tcc acc ttg gct aac gca ctg agt      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aaa gaa tta ggt gag tat aat atc cct gtt ttc gcc att ggg cca aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tat ctg cac tca gaa gat agc cca tac tat tac cca acg gaa ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag atc aac cct gaa cat gtg gcg cat gtt aaa aaa gta aca gcc tta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cgt ctg ggt act caa aaa gaa ctt ggc gag ctg gtt gcg ttt ctc      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gct tct ggt agc tgc gat tac ttg acc ggc caa gtc ttc tgg tta gcc      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggt ggc ttt ccg gtg att gag cgc tgg cca ggt atg ccg gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  166
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  166

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  167
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  167
atg agc act gcg att gtt act aac gtt aaa cat ttc ggt ggt atg ggg       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agt gcg ctg aaa ctg tcg gag gcc ggt cat aca gta gcg tgt cac gat       96
Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agt ttc aaa caa aag gac gaa ttg gaa gcc ttt gcg gaa act tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa ccg atg tca gaa cag gag cca gcg gag tta att gag      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gcg gtc acc agt gcc ttc ggc cag gtg gat gtc ctg gtt agc aac gac      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct ctg gaa ttc cgt ccg att gac aag tat gcc gtc gaa gac      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac cgt ggt gcg gta gaa gca ctg cag atc cgc ccg ttc gcg ttg gtt      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gcc gta gct agt caa atg aaa aaa cgt aaa tca ggt cat att atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc att act agc gcg gct ccg ttt ggt cca tgg aag gag ctg tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tat agt agt gcg cgc gcc ggg gcc tcc acc ttg gct aac gca ctg agt      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aaa gaa tta ggt gag tat aat atc cct gtt ttc gcc att ggg cca aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tat ctg cac tca gaa gat agc cca tac tat tac cca acg gaa ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag atc aac cct gaa cat gtg gcg cat gtt aaa aaa gta aca gcc tta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cgt ctg ggt act caa aaa gaa ctt ggc gag ctg gtt gcg ttt ctc      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gct tct ggt agc tgc gat tac ttg acc ggc caa gtc ttc tgg tta gcc      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggt ggc ttt ccg gtg att gag cgc tgg cca ggt atg ccg gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  168
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  168

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  169
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  169
atg agc act gcg att gtt act aac gtc aaa cat ttc ggt ggt atg ggg       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agt gcg ctg aaa ctg tcg gag gcc ggt cat aca gta gcg tgt cac gat       96
Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agt ttc aaa caa aag gac gaa ttg gaa gcc ttt gcg gaa act tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa ccg atg tca gaa cag gag cca gcg gag tta att gag      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gcg gtc acc agt gcc ttc ggc cag gtg gat gtc ctg gtt agc aac gac      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct ctg gaa ttc cag ccg att gac aag tat gcc gtc gaa gac      288
Ile Phe Ala Leu Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac cgt ggt gcg gta gaa gca ctg cag atc aag ccg ttc gcg ttg gtt      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gcc gta gct agt caa atg aaa aaa cgt aaa tca ggt cat att atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc att act agc gcg agc ccg ttt ggt cca tgg aag gag ctg tcg act      432
Phe Ile Thr Ser Ala Ser Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tat agt agt gcg cgc gcc ggg gcc tcc gcg ttg gct aac gca ctg agt      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aaa gaa tta ggt gag tat aat atc cct gtt ttc gcc att ggg cca aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tat ctg cac tca gaa gat agc cca tac tat tac cca acg gaa cca tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag atc cag cct gaa cat gtg gcg cat gtt aaa aaa gta aca gcc tta      624
Lys Ile Gln Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cgt ctg ggt act caa aaa gaa ctt ggc gag ctg gtt gcg ttt ctc      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gct tct ggt agc tgc gat tac ttg acc ggc caa gtc ttc tgg tta gcc      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggt ggc ttt ccg gtg att gag cgc tgg cca ggt atg ccg gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  170
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  170

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ser Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Gln Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  171
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  171
atg agc act gcg att gtt act aac gtc aaa cat ttc ggt ggt atg ggg       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agt gcg ctg aaa ctg tcg gag gcc ggt cat aca gta gcg tgt cac gat       96
Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agt ttc aaa caa aag gac gaa ttg gaa gcc ttt gcg gaa act tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa ccg atg tca gaa cag gag cca gcg gag tta att gag      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gcg gtc acc agt gcc ttc ggc cag gtg gat gtc ctg gtt agc aac gac      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct ctg gaa ttc cgt ccg att gac aag tat gcc gtc gaa gac      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac cgt ggt gcg gta gaa gca ctg cag atc aag ccg ttc gcg ttg gtt      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gcc gta gct agt caa atg aaa aaa cgt aaa tca ggt cat att atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc att act agc gcg gct ccg ttt ggt cca tgg aag gag ctg tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tat agt agt gcg cgc gcc ggg gcc tcc gcg ttg gct aac gca ctg agt      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aaa gaa tta ggt gag tat aat atc cct gtt ttc gcc att ggg cca aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tat ctg cac tca gaa gat agc cca tac tat tac cca acg gaa ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag atc aac cct gaa cat gtg gcg cat gtt aaa aaa gta aca gcc tta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cgt ctg ggt act caa aaa gaa ctt ggc gag ctg gtt gcg ttt ctc      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gct tct ggt agc tgc gat tac ttg acc ggc caa gtc ttc tgg tta gcc      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggt ggc ttt ccg gtg att gag cgc tgg cca ggt atg ccg gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  172
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  172

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  173
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  173
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc aaa cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

cac tct gtg gct tcc caa atg aag aag cga aag tcg ggg cac atc atc      384
His Ser Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att gat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asp Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  174
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  174

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


His Ser Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asp Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  175
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  175
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Leu Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc gag act ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Glu Thr Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct agt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Ser Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc acg ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Thr Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  176
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  176

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Glu Thr Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Ser Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Thr Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  177
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  177
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc cgc cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg act agt gca cta gct aat gct cta gct      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ala         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg ttc tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  178
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  178

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ala 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  179
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  179
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa gcc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc cgc cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg act agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gct ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  180
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  180

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  181
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  181
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa gcc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct cta cag atc cgc cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg act agt gca cta gct aat gct cta gct      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ala         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg ttc tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gct ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  182
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  182

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ala 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  183
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  183
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg aaa ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa gcc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc cgc cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg act agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg ttc tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag tat gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu Tyr Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

cgt cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Arg Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tcc tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gct ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  184
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  184

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu Tyr Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Arg Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  185
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH


<220>
<221>  CDS
<222>  (1)..(768)

<400>  185
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag tat gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu Tyr Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

cgt cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Arg Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gct ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  186
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  186

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu Tyr Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Arg Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  187
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  187
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa gcc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc cgc cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg act agt gca cta gct aat gct cta gct      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ala         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg ttc tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

cgt cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Arg Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  188
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  188

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ala 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Arg Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  189
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  189
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa gcc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg act agt gca cta gct aat gct cta gct      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ala         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gct ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  190
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  190

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ala 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  191
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  191
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa gcc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg act agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg ttc tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gct ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  192
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  192

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  193
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  193
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg act agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gct ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  194
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  194

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  195
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  195
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa gcc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gcc gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg act agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg ttc tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gct ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  196
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  196

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  197
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  197
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cgt tgg ccc ggc atg ctg gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Leu Glu                 
                245                 250                                 


<210>  198
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  198

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Leu Glu 
                245                 250                 


<210>  199
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  199
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg act agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  200
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  200

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  201
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  201
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac tca gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ser Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cgt tgg ccc ggc atg ctg gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Leu Glu                 
                245                 250                                 


<210>  202
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  202

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ser Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Leu Glu 
                245                 250                 


<210>  203
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  203
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ttg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

cat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
His Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cgt tgg ccc ggc atg ctg gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Leu Glu                 
                245                 250                                 


<210>  204
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  204

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


His Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Leu Glu 
                245                 250                 


<210>  205
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  205
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aag gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

cat tcg gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
His Ser Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg aca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  206
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  206

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


His Ser Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  207
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH


<220>
<221>  CDS
<222>  (1)..(768)

<400>  207
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac tca gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ser Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cgt ttg ccc ggc atg ctg gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Leu Pro Gly Met Leu Glu                 
                245                 250                                 


<210>  208
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  208

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ser Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Leu Pro Gly Met Leu Glu 
                245                 250                 


<210>  209
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  209
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg aaa ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg act agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg ttc tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag tat gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu Tyr Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

cgt cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Arg Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  210
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  210

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu Tyr Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Arg Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  211
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  211
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg aaa ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

ggt agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa gcc tac      144
Gly Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg act agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

cgt cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Arg Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  212
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  212

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Gly Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Arg Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  213
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  213
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggc       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

cat gct gtg gct ccg caa atg aag aag cga aag tcg ggg cac atc atc      384
His Ala Val Ala Pro Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cat gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  214
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  214

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


His Ala Val Ala Pro Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  215
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  215
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg aaa ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

ggt agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa gcc tac      144
Gly Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct cca caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Pro Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg ttc tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gct ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  216
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  216

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Gly Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Pro Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  217
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  217
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa gcc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg act agt gca cta gct aat gct cta gct      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ala         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg ttc tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cgt tgg ccc ggc atg ctg gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Leu Glu                 
                245                 250                                 


<210>  218
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  218

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ala 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Leu Glu 
                245                 250                 


<210>  219
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  219
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa gcc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag aac      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asn         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg ttc tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gct ata gaa cgt tgg ccc ggc atg ctg gaa taa tga      768
Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Leu Glu                 
                245                 250                                 


<210>  220
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  220

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asn 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Leu Glu 
                245                 250                 


<210>  221
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  221
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

ggt agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Gly Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta caa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Gln Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg act agt gca cta gct aat gct cta gct      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ala         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg ttc tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gct ata gaa cgt tgg ccc ggc atg ctg gaa taa tga      768
Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Leu Glu                 
                245                 250                                 


<210>  222
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  222

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Gly Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Gln Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ala 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Leu Glu 
                245                 250                 


<210>  223
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  223
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg aaa ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

ggt agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa gcc tac      144
Gly Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc cgc cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

cat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
His Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

cgt cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Arg Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gct ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  224
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  224

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Gly Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


His Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Arg Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  225
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  225
atg agc acc gct att gtc acc aac gtc aaa cat ttt ggt ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  226
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  226

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  227
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  227
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

ggt agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Gly Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg acc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Thr Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc cgc cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct cca caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Pro Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg ttc tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gct ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  228
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  228

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Gly Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Thr Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Pro Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  229
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  229
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg aaa ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa gcc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg act agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg ttc tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  230
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  230

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  231
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  231
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa gcc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc cgc cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag tat gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu Tyr Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

cgt cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Arg Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gct ata gaa cgt tgg ccc ggc atg ctg gaa taa tga      768
Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Leu Glu                 
                245                 250                                 


<210>  232
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  232

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu Tyr Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Arg Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Leu Glu 
                245                 250                 


<210>  233
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  233
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct cca caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Pro Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg act agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  234
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  234

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Pro Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  235
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  235
atg aac acc gtt att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Asn Thr Val Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ttg aaa ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  236
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  236

Met Asn Thr Val Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  237
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  237
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg aaa ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  238
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  238

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  239
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  239
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg aaa ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gcc ttt gct gaa acc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  240
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  240

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  241
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  241
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg aaa ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  242
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  242

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  243
<211>  768
<212>  DNA
<213>  Artificial

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  243
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg aaa ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg gcc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ala Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tca gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  244
<211>  254
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  244

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ala Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  245
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  245
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg aaa ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca ctg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Leu Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  246
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  246

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Leu Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  247
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  247
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg aaa ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gca atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  248
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  248

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  249
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  249
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg aaa ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

ggt agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Gly Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  250
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  250

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Gly Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  251
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  251
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa gcc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc cgc cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gca gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg act agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg ttc tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag tat gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu Tyr Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gct ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  252
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  252

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu Tyr Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  253
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  253
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa gcc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc cgc cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg act agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac gat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asp Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg ttc tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

cgt cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Arg Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gct ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  254
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  254

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asp Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Arg Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  255
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  255
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa gcc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg ggc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Gly Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc cgc cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg act agt gca cta gct aat gct cta gct      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ala         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

cgt cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Arg Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gct ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  256
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  256

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Gly Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ala 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Arg Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  257
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  257
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag aac      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asn         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cgt tgg ccc ggc atg ctg gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Leu Glu                 
                245                 250                                 


<210>  258
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  258

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asn 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Leu Glu 
                245                 250                 


<210>  259
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  259
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgt cca atc gat aaa tac tca gtc gag aac      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ser Val Glu Asn         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat tcg gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ser Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aag gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  260
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  260

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ser Val Glu Asn 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ser Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  261
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  261
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg act agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cgt tgg ccc ggc atg ctg gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Leu Glu                 
                245                 250                                 


<210>  262
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  262

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Leu Glu 
                245                 250                 


<210>  263
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  263
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac tca gtc gag aac      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ser Val Glu Asn         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc aga cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

cat gct gtg gct cca caa atg aag aag cga aag tcg ggg cac atc atc      384
His Ala Val Ala Pro Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cgt tgg ccc ggc atg ctg gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Leu Glu                 
                245                 250                                 


<210>  264
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  264

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ser Val Glu Asn 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


His Ala Val Ala Pro Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Leu Glu 
                245                 250                 


<210>  265
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  265
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cga tgg ccc gac atg ctg gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Asp Met Leu Glu                 
                245                 250                                 


<210>  266
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  266

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Asp Met Leu Glu 
                245                 250                 


<210>  267
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  267
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta caa ttt cgt cca atc gat aaa tac tca gtc gag aac      288
Ile Phe Ala Leu Gln Phe Arg Pro Ile Asp Lys Tyr Ser Val Glu Asn         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat tcg gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ser Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cgt tgg ccc ggc atg ctg gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Leu Glu                 
                245                 250                                 


<210>  268
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  268

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Gln Phe Arg Pro Ile Asp Lys Tyr Ser Val Glu Asn 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ser Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Leu Glu 
                245                 250                 


<210>  269
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  269
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac tca gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ser Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct cca caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Pro Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cgt tgg ccc ggc atg ccg gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  270
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  270

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ser Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Pro Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  271
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  271
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa gcc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

cat tcg gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
His Ser Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg act agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg ttc tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gct ata gaa cgt tgg ccc ggc atg ctg gaa taa tga      768
Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Leu Glu                 
                245                 250                                 


<210>  272
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  272

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


His Ser Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Leu Glu 
                245                 250                 


<210>  273
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  273
atg aac acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Asn Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg aaa ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa gcc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr         
        35                  40                  45                      

cca cag ctg aaa cca ctg agc gaa caa gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Leu Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gct ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  274
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  274

Met Asn Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Leu Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  275
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  275
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

ggt agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Gly Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta caa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Gln Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc cgc cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg act agt gca cta gct aat gct cta gct      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ala         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg ttc tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag tat gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu Tyr Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

cgt cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Arg Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  276
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  276

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Gly Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Gln Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ala 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu Tyr Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Arg Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  277
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  277
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg aaa ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa gcc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg gcc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ala Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac tca gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ser Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat tcg gtg gct cca caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ser Val Ala Pro Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg ttc tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gct ata gaa cgt tgg ccc ggc atg ctg gaa taa tga      768
Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Leu Glu                 
                245                 250                                 


<210>  278
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  278

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ala Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ser Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ser Val Ala Pro Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Leu Glu 
                245                 250                 


<210>  279
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  279
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg aaa ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

ggt agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa gcc tac      144
Gly Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg gcc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ala Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc cgc cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg act agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  280
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  280

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Gly Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ala Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  281
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  281
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa gcc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gtt gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Gly Val Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg ttc tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gct ata gaa cgt tgg ccc ggc atg ctg gaa taa tga      768
Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Leu Glu                 
                245                 250                                 


<210>  282
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  282

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Val Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Leu Glu 
                245                 250                 


<210>  283
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  283
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg aaa ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac tca gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ser Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat tcg gtg gct cca caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ser Val Ala Pro Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg act agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gct ata gaa cgt tgg ccc ggc atg ctg gaa taa tga      768
Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Leu Glu                 
                245                 250                                 


<210>  284
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  284

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ser Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ser Val Ala Pro Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Leu Glu 
                245                 250                 


<210>  285
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  285
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

ggt agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa gcc tac      144
Gly Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg ttc tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cgt tgg ccc ggt atg ctg gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Leu Glu                 
                245                 250                                 


<210>  286
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  286

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Gly Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Leu Glu 
                245                 250                 


<210>  287
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  287
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cat gtc gat gtc ctg gtc agc aat gat      240
Ala Val Thr Ser Ala Phe Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gct ata gaa cgt tgg ccc ggc atg ctg gaa taa tga      768
Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Leu Glu                 
                245                 250                                 


<210>  288
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  288

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Leu Glu 
                245                 250                 


<210>  289
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  289
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg aaa ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa gcc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg gcc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ala Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgt cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct cca caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Pro Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag tat gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu Tyr Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

cgt cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Arg Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gct ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  290
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  290

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ala Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Pro Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu Tyr Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Arg Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  291
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  291
atg aac acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Asn Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg aaa ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg gcc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ala Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgt cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg ttc tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag tac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu Tyr Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gct ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  292
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  292

Met Asn Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ala Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu Tyr Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  293
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  293
atg agc acc gtt att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Val Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa gcc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr         
        35                  40                  45                      

cca cag ctg aaa cca ctg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Leu Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgt cca atc gat aaa tac tca gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ser Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

cat tcg gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
His Ser Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg ttc tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg acc ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gct ata gaa cgt tgg ccc ggc atg ctg gaa taa tga      768
Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Leu Glu                 
                245                 250                                 


<210>  294
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  294

Met Ser Thr Val Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Leu Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ser Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


His Ser Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Leu Glu 
                245                 250                 


<210>  295
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  295
atg aac acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Asn Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa gcc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac tca gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ser Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct cca caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Pro Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg act agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg ttc tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gct ata gaa cgt tgg ccc ggc atg ctg gaa taa tga      768
Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Leu Glu                 
                245                 250                                 


<210>  296
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  296

Met Asn Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ser Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Pro Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Leu Glu 
                245                 250                 


<210>  297
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  297
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gac ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Asp Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aaa cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg cca tgg aaa gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttc ctg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc ata ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Ile Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  298
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  298

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Asp Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ile Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  299
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  299
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac tca gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ser Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

cat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
His Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cgt tgg ccc ggc atg ctg gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Leu Glu                 
                245                 250                                 


<210>  300
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  300

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ser Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


His Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Leu Glu 
                245                 250                 


<210>  301
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  301
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

cat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
His Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  302
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  302

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


His Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  303
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  303
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa gcc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag aac      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asn         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc cgc cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct cca caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Pro Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg ttc tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ctg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  304
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  304

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asn 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Pro Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  305
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  305
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa gcc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg gcc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ala Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct cca caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Pro Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg ttc tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  306
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  306

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ala Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Pro Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  307
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  307
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa gcc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg act agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gct ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  308
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  308

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  309
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  309
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  310
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  310

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  311
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  311
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca ctg acc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Leu Thr Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  312
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  312

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Leu Thr Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  313
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  313
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg aaa ctg agc gaa gtt ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Lys Leu Ser Glu Val Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca ctg gcc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Leu Ala Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  314
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  314

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Lys Leu Ser Glu Val Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Leu Ala Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  315
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  315
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa gcc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gtt gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Gly Val Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg ttc tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gct ata gaa cgt tgg ccc ggc atg ctg gaa taa tga      768
Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Leu Glu                 
                245                 250                                 


<210>  316
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  316

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Val Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Leu Glu 
                245                 250                 


<210>  317
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  317
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg aaa ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  318
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  318

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  319
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  319
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgt cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc tct ccc gtc ata gaa cgt tgg ccc ggc atg ctg gaa taa tga      768
Gly Gly Ser Pro Val Ile Glu Arg Trp Pro Gly Met Leu Glu                 
                245                 250                                 


<210>  320
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  320

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Ser Pro Val Ile Glu Arg Trp Pro Gly Met Leu Glu 
                245                 250                 


<210>  321
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  HHDH
<222>  (1)..(768)

<220>
<221>  CDS
<222>  (1)..(768)

<400>  321
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg aaa ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca ctg gcc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Leu Ala Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac tca gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ser Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

gag att aat ccg gag tat gtg gct cac gtg aag aag gtg act gct cta      624
Glu Ile Asn Pro Glu Tyr Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

cgt cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Arg Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  322
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  322

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Leu Ala Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ser Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Glu Ile Asn Pro Glu Tyr Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Arg Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  323
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  323
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa gcc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg act agt gca cta gct aat gct cta gct      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ala         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gct ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  324
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  324

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ala 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  325
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  325
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa gcc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg act agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg ttc tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gct ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  326
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  326

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  327
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  327
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa gcc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc cgc cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg ttc tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gct ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  328
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  328

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  329
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  329
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg aaa ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

ggt agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa gcc tac      144
Gly Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg gcc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ala Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac tca gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ser Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

cat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
His Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg act agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg ttc tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  330
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  330

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Gly Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ala Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ser Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


His Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  331
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  331
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca ctg gcc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Leu Ala Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc cgc cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct cca caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Pro Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg ttc tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

cgt cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Arg Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  332
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  332

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Leu Ala Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Pro Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Arg Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  333
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  333
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg aaa ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca ctg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Leu Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  334
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  334

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Leu Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  335
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  335
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg aaa ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

cat gct gtg gct cca caa atg aag aag cga aag tcg ggg cac atc atc      384
His Ala Val Ala Pro Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg act agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg ttc tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

cgt cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Arg Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gct ata gaa cgt tgg ccc ggc atg ctg gaa taa tga      768
Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Leu Glu                 
                245                 250                                 


<210>  336
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  336

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


His Ala Val Ala Pro Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Arg Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Leu Glu 
                245                 250                 


<210>  337
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  337
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg aaa ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

ggt agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Gly Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac tca gtc gag aac      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ser Val Glu Asn         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg act agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gct ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  338
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  338

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Gly Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ser Val Glu Asn 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  339
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  339
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa gcc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr         
        35                  40                  45                      

cca cag ctg aaa cca ctg gcc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Leu Ala Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc cgc cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct gga act agt gca cta gct aat gct cta gct      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ala         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

cgt cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Arg Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cgt tgg ccc ggc atg ctg gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Leu Glu                 
                245                 250                                 


<210>  340
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  340

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Leu Ala Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ala 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Arg Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Leu Glu 
                245                 250                 


<210>  341
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  341
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg aaa ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

ggt agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa gcc tac      144
Gly Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc cgc cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg act agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg ttc tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

cgt cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Arg Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gct ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  342
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  342

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Gly Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Arg Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  343
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  343
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa gcc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc cgc cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg act agt gca cta gct aat gct cta gct      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ala         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg ttc tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag tat gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu Tyr Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gct ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  344
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  344

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ala 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu Tyr Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  345
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  345
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg act agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

cgt cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Arg Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gcg      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gct ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  346
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  346

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Arg Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  347
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  347
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa gcc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc cgc cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg act agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gct ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  348
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  348

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  349
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  349
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cgt tgg ccc ggc atg ctg gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Leu Glu                 
                245                 250                                 


<210>  350
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  350

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Leu Glu 
                245                 250                 


<210>  351
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  351
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa gcc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc cgc cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gcc gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta gct      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ala         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg ttc tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gct ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  352
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  352

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ala 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  353
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  353
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg aaa ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa gcc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr         
        35                  40                  45                      

cca cag ctg aaa cca ctg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Leu Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta caa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Gln Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg act agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg ttc tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag tat gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu Tyr Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  354
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  354

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Leu Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Gln Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu Tyr Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  355
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  355
atg agc acc gct att gtc acc aac gtc aaa cat ttt gaa ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Glu Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  356
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  356

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Glu Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  357
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  357
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa gcc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac tca gtc gag aac      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ser Val Glu Asn         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg ttc tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag tat gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu Tyr Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cgt tgg ccc ggc atg ctg gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Leu Glu                 
                245                 250                                 


<210>  358
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  358

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ser Val Glu Asn 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu Tyr Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Leu Glu 
                245                 250                 


<210>  359
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  359
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac tca gtc gag aac      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ser Val Glu Asn         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

cat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
His Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  360
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  360

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ser Val Glu Asn 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


His Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  361
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  361
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gac gcc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Asp Ala Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc cgc cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg act agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg ttc tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

cgt cga cta ggg act cag aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Arg Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  362
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  362

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Asp Ala Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Arg Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  363
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  363
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg aaa ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa gcc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg gcc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ala Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc cgc cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat tcg gtg gct cca caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ser Val Ala Pro Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg ttc tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cgt tgg ccc ggc atg ctg gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Leu Glu                 
                245                 250                                 


<210>  364
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  364

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ala Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ser Val Ala Pro Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Leu Glu 
                245                 250                 


<210>  365
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  365
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat tcg gtg gct cca caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ser Val Ala Pro Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cgt tgg ccc ggc atg ctg gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Leu Glu                 
                245                 250                                 


<210>  366
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  366

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ser Val Ala Pro Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Leu Glu 
                245                 250                 


<210>  367
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  367
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct atc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Ile Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

cat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
His Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cgt tgg ccc ggc atg ctg gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Leu Glu                 
                245                 250                                 


<210>  368
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  368

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Ile Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


His Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Leu Glu 
                245                 250                 


<210>  369
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  369
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

ggt agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa gcc tac      144
Gly Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac tca gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ser Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct cca caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Pro Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg act agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg ttc tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cgt tgg ccc ggc atg ccc gag taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  370
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  370

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Gly Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ser Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Pro Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  371
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  371
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgt cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

ggt agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa gcc tac      144
Gly Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac tca gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ser Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg act agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag tat gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu Tyr Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

cgt cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Arg Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gct ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  372
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  372

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Gly Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ser Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu Tyr Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Arg Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  373
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  373
atg agc acc gct att gtc acc aac gtc aaa cat ttt ggg ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc cgc cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg act agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg ttc tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cgt tgg ccc ggc atg ctg gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Leu Glu                 
                245                 250                                 


<210>  374
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  374

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Leu Glu 
                245                 250                 


<210>  375
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  375
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac tca gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ser Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc cgc cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

cat gcg gtg gct cca caa atg aag aag cga aag tcg ggg cac atc atc      384
His Ala Val Ala Pro Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg act agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg ttc tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act cag aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gct ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  376
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  376

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ser Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


His Ala Val Ala Pro Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  377
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  377
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa gcc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc cgc cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg act agt gca cta gct aat gct cta gct      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ala         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg ttc tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gct ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  378
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  378

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ala 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  379
<211>  768
<212>  DNA
<213>  Artificial

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  379
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc cgc cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg ttc tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

agg att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Arg Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gct ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  380
<211>  254
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  380

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Arg Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  381
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  381
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg aaa ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa gcc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta caa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Gln Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg act agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

cgt cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Arg Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gct ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  382
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  382

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Gln Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Arg Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  383
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  383
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg aaa ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  384
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  384

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  385
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  385
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg aaa ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa gcc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg gcc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ala Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgt cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct cca caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Pro Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag tat gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu Tyr Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

cgt cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Arg Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gct ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  386
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  386

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ala Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Pro Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu Tyr Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Arg Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  387
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  387
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cga cca atc gat aaa tac gct gtc gag aat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asn         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ctg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  388
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  388

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asn 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  389
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  389
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg aaa ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa gcc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg acc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Thr Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

cgt cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Arg Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gct ata gaa cgt tgg ccc ggc atg ctg gaa taa tga      768
Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Leu Glu                 
                245                 250                                 


<210>  390
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  390

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Thr Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Arg Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Leu Glu 
                245                 250                 


<210>  391
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  391
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gct ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  392
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  392

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  393
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  393
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg aaa ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca ctg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Leu Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  394
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  394

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Leu Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  395
<211>  768
<212>  DNA
<213>  Artificial

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  395
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg aaa ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cga cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat tcg gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ser Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta gct      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ala         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gct ata gaa cgt tgg ccc ggc atg ctg gaa taa tga      768
Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Leu Glu                 
                245                 250                                 


<210>  396
<211>  254
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  396

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ser Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ala 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Leu Glu 
                245                 250                 


<210>  397
<211>  768
<212>  DNA
<213>  Artificial

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  397
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

cat tcg gtg gct cca caa atg aag aag cga aag tcg ggg cac atc atc      384
His Ser Val Ala Pro Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cgt tgg ccc ggc atg ctg gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Leu Glu                 
                245                 250                                 


<210>  398
<211>  254
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  398

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


His Ser Val Ala Pro Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Leu Glu 
                245                 250                 


<210>  399
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  399
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg aaa ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa gcc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac tca gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ser Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct cca caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Pro Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg act agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg ttc tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag tat gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu Tyr Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  400
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  400

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ser Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Pro Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu Tyr Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  401
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  401
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg aaa ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

ggt agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Gly Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac tca gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ser Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc cgc cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gct ata gaa cgt tgg ccc ggc atg ctg gaa taa tga      768
Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Leu Glu                 
                245                 250                                 


<210>  402
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  402

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Gly Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ser Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Leu Glu 
                245                 250                 


<210>  403
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  403
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac tca gtc gag aac      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ser Val Glu Asn         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

cat tcg gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
His Ser Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gcc ata gaa cgt tgg ccc ggc atg ctg gaa taa tga      768
Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Leu Glu                 
                245                 250                                 


<210>  404
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  404

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ser Val Glu Asn 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


His Ser Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Leu Glu 
                245                 250                 


<210>  405
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  405
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa gcc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg act agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg ttc tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  406
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  406

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  407
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  407
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att agt ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Ser Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cgt tgg ccc ggc atg ctg gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Leu Glu                 
                245                 250                                 


<210>  408
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  408

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Ser Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Leu Glu 
                245                 250                 


<210>  409
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  409
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg aaa ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa gcc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg gcc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ala Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac tca gtc gag aac      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ser Val Glu Asn         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg act agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gct ata gaa cgt tgg ccc ggc atg ctg gaa taa tga      768
Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Leu Glu                 
                245                 250                                 


<210>  410
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  410

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ala Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ser Val Glu Asn 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Leu Glu 
                245                 250                 


<210>  411
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  411
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

ggt agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa gcc tac      144
Gly Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr         
        35                  40                  45                      

cca cag ctg aaa cca ctg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Leu Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac tca gtc gag aac      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ser Val Glu Asn         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg act agt gca cta gct aat gct cta gct      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ala         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag tat gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu Tyr Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  412
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  412

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Gly Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Leu Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ser Val Glu Asn 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ala 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu Tyr Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  413
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  413
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgt cat gac       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac tca gtc gag aac      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ser Val Glu Asn         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct cca caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Pro Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  414
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  414

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ser Val Glu Asn 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Pro Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  415
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  415
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg aaa ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa gcc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg act agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg ttc tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

cgt cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Arg Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gct ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  416
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  416

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Phe Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Arg Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  417
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  417
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat tcg gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ser Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cgt tgg ccc ggc atg ctg gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Leu Glu                 
                245                 250                                 


<210>  418
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  418

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ser Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Leu Glu 
                245                 250                 


<210>  419
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  419
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

ggt agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Gly Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  420
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  420

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Gly Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  421
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  421
atg agc agc gct atc gtc act aac gtc aaa cat ttt ggt ggt atg ggt       48
Met Ser Ser Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gga agc ttt aaa cag aaa gat gaa ctg gaa gat ttt gca gac acc tac      144
Gly Ser Phe Lys Gln Lys Asp Glu Leu Glu Asp Phe Ala Asp Thr Tyr         
        35                  40                  45                      

cca cag atg aaa cca atg agc gaa cag gaa cca ggt gaa ctg atc gaa      192
Pro Gln Met Lys Pro Met Ser Glu Gln Glu Pro Gly Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

gtc ttt gct cca gaa ttt cag cca atg gat aaa tac gct gtc gaa gat      288
Val Phe Ala Pro Glu Phe Gln Pro Met Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ccg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Pro Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg ccg tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac ctg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Leu Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  422
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  422

Met Ser Ser Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Gly Ser Phe Lys Gln Lys Asp Glu Leu Glu Asp Phe Ala Asp Thr Tyr 
        35                  40                  45              


Pro Gln Met Lys Pro Met Ser Glu Gln Glu Pro Gly Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Val Phe Ala Pro Glu Phe Gln Pro Met Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Pro Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Leu Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  423
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  423
atg agc agc gct att gtc acc aac ttc aaa cat ttt gga ggt atg ggt       48
Met Ser Ser Ala Ile Val Thr Asn Phe Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cat atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu His Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gcc gct tcc caa atg aac aag cga aag tcg ggg cac atc atc      384
Asn Ala Ala Ala Ser Gln Met Asn Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  424
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  424

Met Ser Ser Ala Ile Val Thr Asn Phe Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu His Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Ala Ala Ser Gln Met Asn Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  425
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  425
atg agc acc gct atc gtc acc aac ttc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Phe Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc atc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ile Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc cag gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Gln Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct acc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt ccc cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Pro Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg cct aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act gac cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Asp Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  426
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  426

Met Ser Thr Ala Ile Val Thr Asn Phe Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ile Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Gln Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Pro Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Asp Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  427
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  427
atg agc acc gct att gtc acc aac ttc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Phe Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa ctg aaa gct ttt gct aaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Lys Ala Phe Ala Lys Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag caa cca gct caa ctg att aaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Gln Pro Ala Gln Leu Ile Lys         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gct gct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Ala Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag agg cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg aca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  428
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  428

Met Ser Thr Ala Ile Val Thr Asn Phe Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Lys Ala Phe Ala Lys Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Gln Pro Ala Gln Leu Ile Lys 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Ala Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  429
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  429
atg agc acc gct att gtc acg aac ttc aca cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Phe Thr His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctc agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa ctg gaa gct ttt gct gac acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Asp Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gct gct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Ala Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt act gtc gaa gct ctg cag atc cgc cca ttt gct cta gtg      336
Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga cgt tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Arg Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag att tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Ile Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

cgt cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg aca ttt ttg      672
Arg Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  430
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  430

Met Ser Thr Ala Ile Val Thr Asn Phe Thr His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Asp Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Ala Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Arg Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Ile Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Arg Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  431
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  431
atg agc acc gtt att gtc acc aac ttc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Val Ile Val Thr Asn Phe Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc act ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Thr Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg act agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag att tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Ile Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

cgt cga cta ggg act caa cgc gag ttg ggg gaa ttg gtg aca ttt ttg      672
Arg Arg Leu Gly Thr Gln Arg Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  432
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  432

Met Ser Thr Val Ile Val Thr Asn Phe Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Thr Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Ile Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Arg Arg Leu Gly Thr Gln Arg Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  433
<211>  711
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(711)

<400>  433
atg gcc aac ggt cgc aaa cgc gag ttc gcg aac ggc cgc ctg gcg ggc       48
Met Ala Asn Gly Arg Lys Arg Glu Phe Ala Asn Gly Arg Leu Ala Gly         
1               5                   10                  15              

aaa ctc gtg ctg ctg acc aac gcc gat gcc tac atg ggt gaa gcg acc       96
Lys Leu Val Leu Leu Thr Asn Ala Asp Ala Tyr Met Gly Glu Ala Thr         
            20                  25                  30                  

gtg cag gtt ttc gag gaa gag ggc gcg gaa gtt ttt gcc gac cac acc      144
Val Gln Val Phe Glu Glu Glu Gly Ala Glu Val Phe Ala Asp His Thr         
        35                  40                  45                      

gac ctg acc aaa gtg ggc gcc gcc gaa gaa gtg gtg gaa cgc gcg ggc      192
Asp Leu Thr Lys Val Gly Ala Ala Glu Glu Val Val Glu Arg Ala Gly         
    50                  55                  60                          

cac atc gat gtg ctg gtt gcc aac ttt gcg gtg gat gcg cac ttt ggt      240
His Ile Asp Val Leu Val Ala Asn Phe Ala Val Asp Ala His Phe Gly         
65                  70                  75                  80          

gtt acc gtg ctg gaa acc gat gaa gag ctg tgg cag acc gcc tat gag      288
Val Thr Val Leu Glu Thr Asp Glu Glu Leu Trp Gln Thr Ala Tyr Glu         
                85                  90                  95              

acc atc gtt cat ccg ctg cac cgt atc tgt cgc gcc gtg ctg ccg cag      336
Thr Ile Val His Pro Leu His Arg Ile Cys Arg Ala Val Leu Pro Gln         
            100                 105                 110                 

ttt tat gaa cgc aac aaa ggc aaa atc gtg gtg tac ggt agc gcc gcc      384
Phe Tyr Glu Arg Asn Lys Gly Lys Ile Val Val Tyr Gly Ser Ala Ala         
        115                 120                 125                     

gcc atg cgt tat caa gaa ggt gcg ctg gcc tac agc acc gcc cgc ttc      432
Ala Met Arg Tyr Gln Glu Gly Ala Leu Ala Tyr Ser Thr Ala Arg Phe         
    130                 135                 140                         

gcg cag cgt ggt tac gtg acc gcc ctg ggc cct gag gcc gcg cgt cac      480
Ala Gln Arg Gly Tyr Val Thr Ala Leu Gly Pro Glu Ala Ala Arg His         
145                 150                 155                 160         

aac gtg aac gtg aac ttc att gcc cag cat tgg acc cag aat aaa gaa      528
Asn Val Asn Val Asn Phe Ile Ala Gln His Trp Thr Gln Asn Lys Glu         
                165                 170                 175             

tac ttc tgg ccg gaa cgc atc gcg acc gac gaa ttc aaa gaa gat atg      576
Tyr Phe Trp Pro Glu Arg Ile Ala Thr Asp Glu Phe Lys Glu Asp Met         
            180                 185                 190                 

gcg cgc cgc gtt ccg ctg ggt cgc ctg gcc acc gcg cgc gaa gac gcg      624
Ala Arg Arg Val Pro Leu Gly Arg Leu Ala Thr Ala Arg Glu Asp Ala         
        195                 200                 205                     

ctg ctg gcc ctg ttt ctg gcg agc gac gaa agc gat ttt atc gtt ggt      672
Leu Leu Ala Leu Phe Leu Ala Ser Asp Glu Ser Asp Phe Ile Val Gly         
    210                 215                 220                         

aaa agc att gag ttt gat ggc ggt tgg gcg acc taa tga                  711
Lys Ser Ile Glu Phe Asp Gly Gly Trp Ala Thr                             
225                 230                 235                             


<210>  434
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  434

Met Ala Asn Gly Arg Lys Arg Glu Phe Ala Asn Gly Arg Leu Ala Gly 
1               5                   10                  15      


Lys Leu Val Leu Leu Thr Asn Ala Asp Ala Tyr Met Gly Glu Ala Thr 
            20                  25                  30          


Val Gln Val Phe Glu Glu Glu Gly Ala Glu Val Phe Ala Asp His Thr 
        35                  40                  45              


Asp Leu Thr Lys Val Gly Ala Ala Glu Glu Val Val Glu Arg Ala Gly 
    50                  55                  60                  


His Ile Asp Val Leu Val Ala Asn Phe Ala Val Asp Ala His Phe Gly 
65                  70                  75                  80  


Val Thr Val Leu Glu Thr Asp Glu Glu Leu Trp Gln Thr Ala Tyr Glu 
                85                  90                  95      


Thr Ile Val His Pro Leu His Arg Ile Cys Arg Ala Val Leu Pro Gln 
            100                 105                 110         


Phe Tyr Glu Arg Asn Lys Gly Lys Ile Val Val Tyr Gly Ser Ala Ala 
        115                 120                 125             


Ala Met Arg Tyr Gln Glu Gly Ala Leu Ala Tyr Ser Thr Ala Arg Phe 
    130                 135                 140                 


Ala Gln Arg Gly Tyr Val Thr Ala Leu Gly Pro Glu Ala Ala Arg His 
145                 150                 155                 160 


Asn Val Asn Val Asn Phe Ile Ala Gln His Trp Thr Gln Asn Lys Glu 
                165                 170                 175     


Tyr Phe Trp Pro Glu Arg Ile Ala Thr Asp Glu Phe Lys Glu Asp Met 
            180                 185                 190         


Ala Arg Arg Val Pro Leu Gly Arg Leu Ala Thr Ala Arg Glu Asp Ala 
        195                 200                 205             


Leu Leu Ala Leu Phe Leu Ala Ser Asp Glu Ser Asp Phe Ile Val Gly 
    210                 215                 220                 


Lys Ser Ile Glu Phe Asp Gly Gly Trp Ala Thr 
225                 230                 235 


<210>  435
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  435
atg agc acc gct att gtc acc aac gtc ctc cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg tct cga gct ggg act agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ser Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  436
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  436

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ser Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  437
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  437
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg tgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Cys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag aaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Lys Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  438
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  438

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Cys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Lys Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  439
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  439
atg agc acc gct atc gtc acc aac gtc aaa cat ttt ggt ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gtt ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc ctt gtt       96
Ser Val Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys Leu Val         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aac tca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Asn Ser Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gga ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Gly Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg ccg tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gat aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Asp Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg atg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Met Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  440
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  440

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Val Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys Leu Val 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Asn Ser Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Gly Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Asp Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Met Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  441
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  441
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc ctt gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys Leu Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca cgt aag gag gtc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Val Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg cgt      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Arg         
                165                 170                 175             

tac cta cac atc ggg gat tcg ccg tac aaa tac ccc tct gag ccg tgg      576
Tyr Leu His Ile Gly Asp Ser Pro Tyr Lys Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  442
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  442

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys Leu Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Val Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Arg 
                165                 170                 175     


Tyr Leu His Ile Gly Asp Ser Pro Tyr Lys Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  443
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  443
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gga agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Gly Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg gcg      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Ala         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  444
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  444

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Gly Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Ala 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  445
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  445
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa ggt ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Gly Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gga agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Gly Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Leu Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ctt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Leu Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct ccg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Pro Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct agt act cta gtt aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Ser Thr Leu Val Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc acg ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Thr Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  446
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  446

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Gly Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Gly Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Leu Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Pro Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Ser Thr Leu Val Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Thr Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  447
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  447
atg agc gcc gct atc gtc acc agc gtc aac cat ttt ggt ggt atg ggt       48
Met Ser Ala Ala Ile Val Thr Ser Val Asn His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg aac gaa gct ggt cat acc ttc gct tgc cat gat       96
Ser Ala Leu Arg Leu Asn Glu Ala Gly His Thr Phe Ala Cys His Asp         
            20                  25                  30                  

gga agc ttt aac cag aaa gat gaa ctg gaa gct ttt act gaa gcc tac      144
Gly Ser Phe Asn Gln Lys Asp Glu Leu Glu Ala Phe Thr Glu Ala Tyr         
        35                  40                  45                      

gca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Ala Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg ccg tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt aag ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Lys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  448
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  448

Met Ser Ala Ala Ile Val Thr Ser Val Asn His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Asn Glu Ala Gly His Thr Phe Ala Cys His Asp 
            20                  25                  30          


Gly Ser Phe Asn Gln Lys Asp Glu Leu Glu Ala Phe Thr Glu Ala Tyr 
        35                  40                  45              


Ala Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Lys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  449
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  449
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ctg cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Leu Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act ggt cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Gly Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  450
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  450

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Leu Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Gly Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  451
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  451
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc caa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Gln Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct agt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Ser Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  452
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  452

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Gln Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Ser Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  453
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  453
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa gtc gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Val Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ctg cat cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Leu His Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg tct act ccg ctg ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ser Thr Pro Leu Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag ctg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Leu Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  454
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  454

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Val Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Leu His Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ser Thr Pro Leu Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Leu Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  455
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  455
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gat ctg gaa gct ttt gct gat acc tac      144
Glu Ser Phe Lys Gln Lys Asp Asp Leu Glu Ala Phe Ala Asp Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gcg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Ala Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gcc ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  456
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  456

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Asp Leu Glu Ala Phe Ala Asp Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Ala Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  457
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  457
atg agc acc gct atc gtc act aac gtc aaa cat ttt ggt ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg ccg tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga ctg ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg atg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Met Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  458
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  458

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Met Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  459
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  459
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca gtg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Val Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg gcg      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Ala         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg aag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Lys Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  460
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  460

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Val Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Ala 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Lys Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  461
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  461
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca gtg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Val Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gca gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  462
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  462

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Val Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  463
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  463
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca gtg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Val Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  464
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  464

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Val Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  465
<211>  774
<212>  DNA
<213>  Artificial

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  465
atg agc acc gct att gtc acc aac gtc aaa cat ttt ggg ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca gtg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Val Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg act agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 

gga ccc                                                              774
Gly Pro                                                                 
255                                                                     


<210>  466
<211>  254
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  466

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Val Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  467
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  467
atg agc gcc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Ala Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt tat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly Tyr Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca gtg agc gaa cag gaa cca act gaa ctg att gaa      192
Pro Gln Leu Ile Pro Val Ser Glu Gln Glu Pro Thr Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc ggt gct ctt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Gly Ala Leu Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc tat cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Tyr Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa cgc gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Arg Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  468
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  468

Met Ser Ala Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly Tyr Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Val Ser Glu Gln Glu Pro Thr Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Gly Ala Leu Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Tyr Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Arg Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  469
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  469
atg ggc ccc gtt atg gtc act aac gtc aaa cat ttt ggt ggt aag ggt       48
Met Gly Pro Val Met Val Thr Asn Val Lys His Phe Gly Gly Lys Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca gtg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Val Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg ccg tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aaa gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg acg ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttc tcc aag aaa aaa agt tgg ccc ggc ttg ccc gaa taa tga      768
Gly Gly Phe Ser Lys Lys Lys Ser Trp Pro Gly Leu Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  470
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  470

Met Gly Pro Val Met Val Thr Asn Val Lys His Phe Gly Gly Lys Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Val Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Ser Lys Lys Lys Ser Trp Pro Gly Leu Pro Glu 
                245                 250                 


<210>  471
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  471
atg agc acc gct atc gtc act aac gtc aaa cat ttt ggt ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg cgt ccg atg cgt gat cag gaa cca ccg gac ctg atc gaa      192
Pro Gln Leu Arg Pro Met Arg Asp Gln Glu Pro Pro Asp Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg ccg tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  472
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  472

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Arg Pro Met Arg Asp Gln Glu Pro Pro Asp Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  473
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  473
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gat cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Asp Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc gga cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cat tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct cct gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg cct gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  474
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  474

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Asp Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  475
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  475
atg agc gcc ggt atc gtc acc atc gtc aaa cat ttt ggt ggt atg gga       48
Met Ser Ala Gly Ile Val Thr Ile Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc cct ctg agg ctg atc gaa gct ggt cat acc gtc gct tgc cat gag       96
Ser Pro Leu Arg Leu Ile Glu Ala Gly His Thr Val Ala Cys His Glu         
            20                  25                  30                  

gaa agc ttt aat cag aaa gat gat ctg gaa gct ttt ggt gat acc tgc      144
Glu Ser Phe Asn Gln Lys Asp Asp Leu Glu Ala Phe Gly Asp Thr Cys         
        35                  40                  45                      

cca cag ctg aaa cca atg agg gat cag gga cca gct gat ctg atc gaa      192
Pro Gln Leu Lys Pro Met Arg Asp Gln Gly Pro Ala Asp Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg ccg tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  476
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  476

Met Ser Ala Gly Ile Val Thr Ile Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Pro Leu Arg Leu Ile Glu Ala Gly His Thr Val Ala Cys His Glu 
            20                  25                  30          


Glu Ser Phe Asn Gln Lys Asp Asp Leu Glu Ala Phe Gly Asp Thr Cys 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Arg Asp Gln Gly Pro Ala Asp Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  477
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  477
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat aaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Lys Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc aaa cag aaa cca gct aaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Lys Gln Lys Pro Ala Lys Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gct gct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Ala Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc cca gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg aca ttt tcg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Ser         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  478
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  478

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Lys Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Lys Gln Lys Pro Ala Lys Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Ala Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Ser 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  479
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  479
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat aaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Lys Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc aaa cag aaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Lys Gln Lys Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gct gct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Ala Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg aca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  480
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  480

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Lys Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Lys Gln Lys Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Ala Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  481
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  481
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa ctg aaa gct ttt gct aaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Lys Ala Phe Ala Lys Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc caa cag aaa cca gct aaa ctg att caa      192
Pro Gln Leu Ile Pro Met Ser Gln Gln Lys Pro Ala Lys Leu Ile Gln         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gct gct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Ala Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg aca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  482
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  482

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Lys Ala Phe Ala Lys Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Gln Gln Lys Pro Ala Lys Leu Ile Gln 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Ala Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  483
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  483
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc caa cag aaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Gln Gln Lys Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gct gct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Ala Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg aca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gcg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Ala Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  484
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  484

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Gln Gln Lys Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Ala Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Ala Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  485
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  485
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag aaa cca gct aaa ctg att aaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Lys Pro Ala Lys Leu Ile Lys         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gct gct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Ala Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg aca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  486
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  486

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Lys Pro Ala Lys Leu Ile Lys 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Ala Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  487
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  487
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agt ttt aag cat cag gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg atg cca atg agc gaa cag aaa cca gct caa ctg att caa      192
Pro Gln Leu Met Pro Met Ser Glu Gln Lys Pro Ala Gln Leu Ile Gln         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gct gct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Ala Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt act gac gaa gct ctg cag ttc aag cca ttt gct cta gtg      336
Tyr Arg Gly Thr Asp Glu Ala Leu Gln Phe Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

cac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
His Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta tac tcg gag gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu Tyr Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg aca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  488
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  488

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Met Pro Met Ser Glu Gln Lys Pro Ala Gln Leu Ile Gln 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Ala Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Thr Asp Glu Ala Leu Gln Phe Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


His Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu Tyr Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  489
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  489
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cac acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gag gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg gtt gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Val Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg cct ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  490
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  490

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Val Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  491
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  491
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg tcg cag gct ggt cac acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Gln Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gag gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg gtt gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Val Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  492
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  492

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Gln Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Val Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  493
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  493
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg tcg gag gct ggt cac acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg gtt gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Val Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct ccg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Pro Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  494
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  494

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Val Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Pro Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  495
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  495
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gag cag gaa cca gct gaa ctg gtt gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Val Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  496
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  496

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Val Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  497
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  497
atg agc acc tct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ser Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt agg cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Arg His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg gtt gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Val Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gag      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Glu         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aga tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Arg Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc cca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  498
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  498

Met Ser Thr Ser Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Arg His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Val Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Glu 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Arg Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  499
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  499
atg agc acc gct acc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Thr Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg aag ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa gcc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gat cca gct gac ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Asp Pro Ala Asp Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aaa cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg cca tgg aaa gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act ctg gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga tta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttc ctg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc cta ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Leu Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  500
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  500

Met Ser Thr Ala Thr Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Asp Pro Ala Asp Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Leu Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  501
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(765)

<400>  501
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa aac      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asn         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg cca tgg aaa gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc att atc gaa cgt tgg ccc ggc atg ccc gaa taa          765
Gly Gly Phe Pro Ile Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  502
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  502

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asn 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ile Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  503
<211>  696
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(696)

<400>  503
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gcc cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat ttt ctg                                      696
Ala Ser Gly Ser Cys Asp Phe Leu                                         
225                 230                                                 


<210>  504
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  504

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Phe Leu 
225                 230         


<210>  505
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(765)

<400>  505
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt ctg acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly Leu Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gga acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Gly Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aaa cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg tct act ccg ttc ggg cca tgg aaa gag cta tcg act      432
Phe Ile Thr Ser Ser Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt gct cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt cct cta ata gaa cgt tgg ccc ggc atg ccc gaa taa          765
Gly Gly Phe Pro Leu Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  506
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  506

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly Leu Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Gly Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ser Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Leu Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  507
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  507
atg agc acc gtt atc gtc acc aac gtc aaa cat ttt gga ggt atg gcc       48
Met Ser Thr Val Ile Val Thr Asn Val Lys His Phe Gly Gly Met Ala         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt caa acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly Gln Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt ggt gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Gly Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gcc tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  508
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  508

Met Ser Thr Val Ile Val Thr Asn Val Lys His Phe Gly Gly Met Ala 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly Gln Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Gly Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  509
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  509
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cgt gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly Arg Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct ccg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Pro Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gca ccg ttc ggg cca tgg aag gag ctc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  510
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  510

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly Arg Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Pro Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  511
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  511
atg acc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Thr Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc cag gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Gln Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gct ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  512
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  512

Met Thr Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Gln Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  513
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  513
atg acc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Thr Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gac ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Asp Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc cag gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Gln Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gct ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt tcc cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Ser Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttc ctg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  514
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  514

Met Thr Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Asp Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Gln Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Ser Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  515
<211>  774
<212>  DNA
<213>  Artificial

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  515
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cac aaa gat gat ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Lys Asp Asp Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg tct act ccg ttc ggg cca tgg aaa gag cta tcg act      432
Phe Ile Thr Ser Ser Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat gtg ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Val Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac atg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Met Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc cta ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Leu Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  516
<211>  254
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  516

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Asp Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ser Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Val Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Met Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Leu Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  517
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  517
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gcc ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  518
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  518

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  519
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  519
atg agc acc gct atc gtc act aac gtc aaa cat ttt ggt ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt gat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly Asp Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ccg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Pro Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tca caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg tct act ccg ttc ggg ccg tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ser Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct cgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Arg Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gta gag tac aat atc ccg gtg ttc gca att ttg tct aat      528
Lys Glu Leu Val Glu Tyr Asn Ile Pro Val Phe Ala Ile Leu Ser Asn         
                165                 170                 175             

tac cta ctc tct gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu Leu Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gag gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Glu Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  520
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  520

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly Asp Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Pro Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ser Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Arg Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Val Glu Tyr Asn Ile Pro Val Phe Ala Ile Leu Ser Asn 
                165                 170                 175     


Tyr Leu Leu Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Glu Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  521
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  521
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ccg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Pro Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca aaa aag gag ctc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Lys Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aag      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Lys         
                165                 170                 175             

tac cta cac acc ggg gat tcg ccg tac cgc tac ccc tct gag ccg tgg      576
Tyr Leu His Thr Gly Asp Ser Pro Tyr Arg Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  522
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  522

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Pro Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Lys Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Lys 
                165                 170                 175     


Tyr Leu His Thr Gly Asp Ser Pro Tyr Arg Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  523
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  523
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gca tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc tgc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Cys Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  524
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  524

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Cys Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  525
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  525
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc tgc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Cys Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc aaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Lys Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  526
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  526

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Cys Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Lys Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  527
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  527
atg agc acc gct atc gtc acc aac atc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Ile Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gag gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Glu Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

gtc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Val Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  528
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  528

Met Ser Thr Ala Ile Val Thr Asn Ile Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Glu Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Val Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  529
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  529
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct ccg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Pro Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct agt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Ser Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  530
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  530

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Pro Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Ser Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  531
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  531
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt ggt gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Gly Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cgt atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly Arg Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  532
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  532

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Gly Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly Arg Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  533
<211>  774
<212>  DNA
<213>  Artificial

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  533
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gat ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Asp Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gac ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Asp Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa aac      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asn         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg cca tgg aaa gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc att atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Ile Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  534
<211>  254
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  534

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Asp Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Asp Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asn 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ile Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  535
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  535
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt ctg acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly Leu Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa gcc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gac ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Asp Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttc gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aaa cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg cca tgg aaa gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gcc ggg gcg tgt gct cta gcg aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat gtg ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Val Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttc ctg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc cta ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Leu Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  536
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  536

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly Leu Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Asp Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Val Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Leu Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  537
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  537
atg agc acc gct atc gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gga gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Gly Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ctg cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Leu Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cgt atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly Arg Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ctg ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Leu Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag agc aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ser Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  538
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  538

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Gly Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Leu Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly Arg Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Leu Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ser Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  539
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  539
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gag cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat gaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Glu Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  540
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  540

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Glu Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  541
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  541
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gat gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Asp Val Glu Asp         
                85                  90                  95              

tac agg ggt act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  542
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  542

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Asp Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  543
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  543
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc ggg gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Gly Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  544
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  544

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Gly Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  545
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  545
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc ggg gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Gly Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct aag gtc cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Lys Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gat cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Asp Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  546
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  546

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Gly Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Lys Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Asp Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  547
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  547
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct atc acc agc gct ctt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Ile Thr Ser Ala Leu Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gct gct gtg gaa tgg cgg cca atc gat aaa tac gct gtc ggg gat      288
Ile Ala Ala Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Gly Asp         
                85                  90                  95              

tac agg ggt act gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg aca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  548
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  548

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Ile Thr Ser Ala Leu Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Ala Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Gly Asp 
                85                  90                  95      


Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  549
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  549
atg agc acc gct att gtc acc aac gtc aga cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Arg His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc ggg gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Gly Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  550
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  550

Met Ser Thr Ala Ile Val Thr Asn Val Arg His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Gly Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  551
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  551
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa ggt ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Gly Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tat gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc agt cag ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Gln Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct agt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Ser Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  552
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  552

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Gly Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Gln Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Ser Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  553
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  553
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa ggt ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Gly Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tat gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc cag cgg ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Gln Arg Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct agt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Ser Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  554
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  554

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Gly Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Gln Arg Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Ser Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  555
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  555
atg agc acc gct atc gtc act aac gtc aaa cat ttt ggt ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg ccg tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  556
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  556

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  557
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  557
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gat cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Asp Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gct gct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Ala Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg aca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  558
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  558

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Asp Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Ala Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  559
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  559
atg agc acc gct att gtc acg aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttc ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc tat gct cta caa ttt cgt cca atc gat aaa tac gct gtc gag gat      288
Ile Tyr Ala Leu Gln Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag gtc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Val Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg act agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg aca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  560
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  560

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Tyr Ala Leu Gln Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Val Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  561
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  561
atg agc acc gct gtc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Val Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcc caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att gat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asp Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc acg ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Thr Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  562
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  562

Met Ser Thr Ala Val Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asp Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Thr Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  563
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  563
atg aac acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Asn Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa gcc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gcc cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc acc tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg act agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc tct gat ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Ser Asp Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg aca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  564
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  564

Met Asn Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Ser Asp Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  565
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  565
atg acc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Thr Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

att ttt gct cca gaa ttt cgt cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cgt atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly Arg Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ctg ctg ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Leu Leu Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  566
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  566

Met Thr Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly Arg Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Leu Leu Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  567
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  567
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc atg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Met Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct gcg caa atg aag aaa cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ala Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gcc ggg gcg tgt gct cta gcg aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act ggt cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Gly Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgc tgg ccc gtt atg ccc gaa taa tga      768
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Val Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  568
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  568

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Met Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ala Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Gly Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Val Met Pro Glu 
                245                 250                 


<210>  569
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  569
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc cag gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Gln Asp         
                85                  90                  95              

tac cgt ggt gct gat gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Asp Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tgc act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Cys Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg agc gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ctg act ggc cag gtg tgc tgg ctg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Cys Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccg atg ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  570
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  570

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Gln Asp 
                85                  90                  95      


Tyr Arg Gly Ala Asp Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Cys Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Cys Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  571
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  571
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct agt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Ser Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  572
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  572

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Ser Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  573
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  573
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg ggc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Gly Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ctg cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Leu Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct gtt gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Val Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ctg ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Leu Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act ggt cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Gly Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  574
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  574

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Gly Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Leu Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Val Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Leu Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Gly Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  575
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  575
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gat ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Asp Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa tct cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Ser Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aaa cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg tct act ccg ttc ggg cca tgg aaa gag cta tcg act      432
Phe Ile Thr Ser Ser Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttc ctg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc cta ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Leu Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  576
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  576

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Asp Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Ser Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ser Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Leu Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  577
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  577
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa ggt ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Gly Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tat gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc cag gag ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Gln Glu Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct agt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Ser Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  578
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  578

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Gly Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Gln Glu Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Ser Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  579
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  579
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg tgg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Trp Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt gaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Glu Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gca gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct ccg caa atg aag aaa cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Pro Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gcc agt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Ser Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act gat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asp Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  580
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  580

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Trp Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Glu Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Pro Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Ser Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asp Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  581
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  581
atg agc acc gct atc gtc act aac gtc aaa cat ttt ggt ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa ccg atg cgt gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Arg Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg ccg tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg atg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Met Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  582
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  582

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Arg Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Met Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  583
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  583
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg aag ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gat ctg gaa gct ttt gct gaa gcc tac      144
Glu Ser Phe Lys Gln Lys Asp Asp Leu Glu Ala Phe Ala Glu Ala Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa aac      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asn         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aaa cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg cca tgg aaa gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat gtg ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Val Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac ctg cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ctg gtg gca ttc ctg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc cta ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Leu Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  584
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  584

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Asp Leu Glu Ala Phe Ala Glu Ala Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asn 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Val Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Leu Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  585
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  585
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat ggt gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Gly Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag atg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Met Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  586
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  586

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Gly Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Met Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  587
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  587
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

tat gct gcc gct tcg caa atg aag aag cga aag gcg ggg cac atc atc      384
Tyr Ala Ala Ala Ser Gln Met Lys Lys Arg Lys Ala Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ctg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  588
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  588

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Tyr Ala Ala Ala Ser Gln Met Lys Lys Arg Lys Ala Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  589
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  589
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aac aag cca aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Asn Lys Pro Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggg atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  590
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  590

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Asn Lys Pro Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  591
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  591
atg aag ccc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Lys Pro Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg aaa ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg cgt cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Arg Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gct gct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Ala Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gtt gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Gly Val Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag gag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg act agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg act cac gtg cgt aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Thr His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  592
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  592

Met Lys Pro Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Arg Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Ala Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Val Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Thr His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  593
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  593
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag gag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gac tat ttg act ggc cag gtg ttt tgg ttg agc      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ser         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  594
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  594

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ser 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  595
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  595
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aaa act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc aaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Lys Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  596
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  596

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Lys Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  597
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  597
atg agc acc gtt att gtc acc aat gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Val Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

gcg gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ala Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag gag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gcc atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  598
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  598

Met Ser Thr Val Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ala Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  599
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  599
atg agc acc gct atc gtc acc acg gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Thr Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc tat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Tyr Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cca aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Pro Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag gag gtg att gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Glu Val Ile Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ctg act gtg cag gtg gtg tgg ctg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Val Gln Val Val Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccg atg atc gaa cgt tgg ccg ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  600
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  600

Met Ser Thr Ala Ile Val Thr Thr Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Tyr Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Pro Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Glu Val Ile Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Val Gln Val Val Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  601
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  601
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gag cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc gtc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Val Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  602
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  602

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Val Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  603
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  603
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gca ccg ttc ggg cca cat aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro His Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gcc cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  604
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  604

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro His Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  605
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  605
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gca ccg ttc ggg cca cat aag gag ctc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro His Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aag      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Lys         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  606
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  606

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro His Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Lys 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  607
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  607
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca cat aag gag gtc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro His Lys Glu Val Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  608
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  608

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro His Lys Glu Val Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  609
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  609
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg atc cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc tat cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Tyr Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt act gtc gaa gct cta cag atc aag cca ttt gct cta gtg      336
Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gca ccg ttc ggg cca cat aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro His Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ctg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg aca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Thr         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  610
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  610

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Tyr Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro His Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Thr 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  611
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  611
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agg ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Arg Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gga ccg ttc ggg cca cat aag gag gtc tcg act      432
Phe Ile Thr Ser Ala Gly Pro Phe Gly Pro His Lys Glu Val Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aaa gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act gac cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Asp Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  612
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  612

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Arg Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Gly Pro Phe Gly Pro His Lys Glu Val Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Asp Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  613
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  613
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc cac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr His         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gca ccg ttc ggg cca tgg aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac acc ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  614
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  614

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr His 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  615
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  615
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gag cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gac      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca aaa aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Lys Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca ctg gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac agc ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  616
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  616

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Lys Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  617
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  617
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg atc cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc tat cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Tyr Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca aaa aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Lys Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ctg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg aca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Thr         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  618
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  618

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Tyr Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Lys Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Thr 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  619
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  619
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg cta agc gaa gct ggt ctg acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly Leu Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg acc      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Thr         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg gcc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Met Ile Glu Arg Trp Ala Gly Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  620
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  620

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly Leu Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Thr 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Ala Gly Met Pro Glu 
                245                 250                 


<210>  621
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(765)

<400>  621
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc caa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Gln Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg cca tgg aag gag cta tcg agt      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Ser         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt tcc cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Ser Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa          765
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  622
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  622

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Gln Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Ser 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Ser Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  623
<211>  771
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(771)

<400>  623
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca gtg gac aaa tac tca gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Val Asp Lys Tyr Ser Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 

gga                                                                  771
Gly                                                                     
255                                                                     


<210>  624
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  624

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Val Asp Lys Tyr Ser Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  625
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  625
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc ttt      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Phe         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat gtg ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Val Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc cac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe His Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  626
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  626

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Phe 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Val Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe His Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  627
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  627
atg aac acc gct att gtc acg aac gtc aaa cat ttt gga ggt atg ggt       48
Met Asn Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa ctg gaa gct ttt gct gac gcc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Asp Ala Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tat ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gct gct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Ala Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gtt gtc gaa gct ctg cag atc cgc cca ttt gct cta gtg      336
Tyr Arg Gly Val Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg act agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

cgt cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg aca ttt ttg      672
Arg Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  628
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  628

Met Asn Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Asp Ala Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Ala Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Val Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Arg Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  629
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  629
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg act agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggt cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  630
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  630

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  631
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  631
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg cgt cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Arg Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gct gct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Ala Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg act agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg aca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  632
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  632

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Arg Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Ala Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  633
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  633
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gac acc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Asp Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gct gct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Ala Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg act agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  634
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  634

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Asp Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Ala Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  635
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  635
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gac gcc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Asp Ala Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc att gct cta gaa ttt cag cca atc gat aaa tac gct gtc gag gat      288
Ile Ile Ala Leu Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gtt gtc gaa gct ctg cag gtc cgc cca ttt gct cta gtg      336
Tyr Arg Gly Val Val Glu Ala Leu Gln Val Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg act agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  636
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  636

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Asp Ala Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ile Ala Leu Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Val Val Glu Ala Leu Gln Val Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  637
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  637
atg agc gcc gct att gtc acg aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Ala Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg aaa ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa ctg gaa gct ttt gct gac acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Asp Thr Tyr         
        35                  40                  45                      

cca cag ctg cgt cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Arg Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tat ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc tat gct cta gaa ttt cgt cca atc gat aaa tac gct gtc gag gat      288
Ile Tyr Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg act agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa cgc gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Arg Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ctc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Leu Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  638
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  638

Met Ser Ala Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Lys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Asp Thr Tyr 
        35                  40                  45              


Pro Gln Leu Arg Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Tyr Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Arg Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Leu Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  639
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  639
atg agc acc gct atc gtc acc aac atc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Ile Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg cgg cca atg agc gaa cag gaa cca gct gac atg atc gaa      192
Pro Gln Leu Arg Pro Met Ser Glu Gln Glu Pro Ala Asp Met Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  640
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  640

Met Ser Thr Ala Ile Val Thr Asn Ile Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Arg Pro Met Ser Glu Gln Glu Pro Ala Asp Met Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  641
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  641
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc cag gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Gln Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gct ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt tcc cta gct aat gct cta gct      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Ser Leu Ala Asn Ala Leu Ala         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

cga cga cta ggg act caa gaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Arg Arg Leu Gly Thr Gln Glu Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  642
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  642

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Gln Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Ser Leu Ala Asn Ala Leu Ala 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Arg Arg Leu Gly Thr Gln Glu Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  643
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  643
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  644
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  644

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  645
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  645
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gat ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Asp Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gat cca gct gac ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Asp Pro Ala Asp Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa aac      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asn         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aaa cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg cca tgg aaa gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttc ctg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc att atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Ile Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  646
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  646

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Asp Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Asp Pro Ala Asp Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asn 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ile Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  647
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  647
atg agc acc gct atc gtc act aac gtc aaa cat ttt ggt ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg ccg tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga ggg tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Gly Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  648
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  648

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Gly Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  649
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  649
atg agc acc gct atc gtc act aac gtc aaa cat ttt ggt ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa ccg atg cgt gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Arg Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gac      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg ccg tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg atg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Met Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  650
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  650

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Arg Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Met Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  651
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  651
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc acc gtg tac gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Thr Val Tyr Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gac tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cgt tgg ccc ggc atg ccc gga taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Gly                 
                245                 250                                 


<210>  652
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  652

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Thr Val Tyr Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Gly 
                245                 250                 


<210>  653
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  653
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc acc gtg tac gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Thr Val Tyr Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  654
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  654

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Thr Val Tyr Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  655
<211>  696
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(696)

<400>  655
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gca tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg cat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro His         
                165                 170                 175             

ttt cta aac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Phe Leu Asn Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg                                      696
Ala Ser Gly Ser Cys Asp Tyr Leu                                         
225                 230                                                 


<210>  656
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  656

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro His 
                165                 170                 175     


Phe Leu Asn Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu 
225                 230         


<210>  657
<211>  696
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(696)

<400>  657
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

ttt cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Phe Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg                                      696
Ala Ser Gly Ser Cys Asp Tyr Leu                                         
225                 230                                                 


<210>  658
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  658

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Phe Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu 
225                 230         


<210>  659
<211>  696
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(696)

<400>  659
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

ttt cta cag tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Phe Leu Gln Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg                                      696
Ala Ser Gly Ser Cys Asp Tyr Leu                                         
225                 230                                                 


<210>  660
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  660

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Phe Leu Gln Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu 
225                 230         


<210>  661
<211>  696
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(696)

<400>  661
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg cat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro His         
                165                 170                 175             

ttt cta aac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Phe Leu Asn Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg                                      696
Ala Ser Gly Ser Cys Asp Tyr Leu                                         
225                 230                                                 


<210>  662
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  662

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro His 
                165                 170                 175     


Phe Leu Asn Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu 
225                 230         


<210>  663
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  663
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc cca gtg ttc gct atc ggg cca aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

ttt cta cac tcg gag gat tcg aag tac tat tac ccc act gag ccg tgg      576
Phe Leu His Ser Glu Asp Ser Lys Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gac tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  664
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  664

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Phe Leu His Ser Glu Asp Ser Lys Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  665
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  665
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca cgt aag gag gtc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Val Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg cgt      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Arg         
                165                 170                 175             

tac cta cac atc ggg gat tcg ccg tac cgc tac ccc tct gag ccg tgg      576
Tyr Leu His Ile Gly Asp Ser Pro Tyr Arg Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  666
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  666

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Val Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Arg 
                165                 170                 175     


Tyr Leu His Ile Gly Asp Ser Pro Tyr Arg Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  667
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  667
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gga ccg ttc ggg cca cgt aag gag gtc tcg act      432
Phe Ile Thr Ser Ala Gly Pro Phe Gly Pro Arg Lys Glu Val Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg cgt      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Arg         
                165                 170                 175             

tac cta cac acc ggg gat tcg ccg tac tgg tac ccc tct gag ccg tgg      576
Tyr Leu His Thr Gly Asp Ser Pro Tyr Trp Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ctg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  668
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  668

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Gly Pro Phe Gly Pro Arg Lys Glu Val Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Arg 
                165                 170                 175     


Tyr Leu His Thr Gly Asp Ser Pro Tyr Trp Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  669
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  669
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gga      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Gly         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag gtc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Val Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac acc ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gta acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  670
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  670

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Gly 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Val Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  671
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  671
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gtt gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gca ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac acc ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ctg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  672
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  672

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  673
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  673
atg agg acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Arg Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gga cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Gly Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg cgt      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Arg         
                165                 170                 175             

tac cta cac gac ggg gat tcg ccg tac cgc tac ccc tct gag ccg tgg      576
Tyr Leu His Asp Gly Asp Ser Pro Tyr Arg Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg tcc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Ser Gly Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  674
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  674

Met Arg Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Gly Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Arg 
                165                 170                 175     


Tyr Leu His Asp Gly Asp Ser Pro Tyr Arg Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Ser Gly Met Pro Glu 
                245                 250                 


<210>  675
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  675
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg gcg      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Ala         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg att gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Ile Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  676
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  676

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Ala 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Ile Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  677
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  677
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac att atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tct gcg      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Ala         
    130                 135                 140                         

tac tct tcg tct cga gct ggg act agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ser Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg att gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Ile Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  678
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  678

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Ala 
    130                 135                 140                 


Tyr Ser Ser Ser Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Ile Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  679
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  679
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg aag tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Lys Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gac      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Asp         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  680
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  680

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Lys Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Asp 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  681
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  681
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cta gaa ttt cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg aag tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Lys Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  682
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  682

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Leu Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Lys Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  683
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  683
atg acc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Thr Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggg cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gct tcg gct cga gct ggg gct tgt tcc cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Cys Ser Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ctg tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Leu Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  684
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  684

Met Thr Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Cys Ser Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Leu Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  685
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  685
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ctg cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Leu Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  686
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  686

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Leu Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  687
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  687
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ctg cat cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Leu His Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  688
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  688

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Leu His Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  689
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  689
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct agt tct cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Ser Ser Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  690
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  690

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Ser Ser Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  691
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  691
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agt gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ctg cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Leu Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct gtt gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Val Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ctg ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Leu Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  692
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  692

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Leu Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Val Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Leu Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  693
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  693
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ctg ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Leu Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act ctg gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag aac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu Asn Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  694
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  694

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Leu Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu Asn Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  695
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  695
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa gtc gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Val Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ctg cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Leu Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ctg ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Leu Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag aac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu Asn Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag ctg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Leu Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  696
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  696

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Val Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Leu Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Leu Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu Asn Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Leu Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  697
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  697
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa gtc gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Val Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ctg ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Leu Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg ggg aac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Gly Asn Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  698
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  698

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Val Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Leu Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Gly Asn Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  699
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  699
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa gtc gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Val Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cgt cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag ttg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Leu Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag aac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu Asn Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ctg tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Leu Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  700
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  700

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Val Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Leu Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu Asn Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Leu Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  701
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  701
atg agc acc gct atc gtc acc aac gtc aaa cat ttt ggt ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca aaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Lys Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta ggg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Gly         
            100                 105                 110                 

aat gct ggg gct tcg caa atg aag aac caa aag acg gtg cac atc atc      384
Asn Ala Gly Ala Ser Gln Met Lys Asn Gln Lys Thr Val His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc gca tcg tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Ala Ser Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

cac act tct gct cga gct ggg ggt tgt act cta act aat gct cta tcg      480
His Thr Ser Ala Arg Ala Gly Gly Cys Thr Leu Thr Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta ggg gag tac aat atg ccg gag cta gct atc gag gcg aat      528
Lys Glu Leu Gly Glu Tyr Asn Met Pro Glu Leu Ala Ile Glu Ala Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tca tcg gac ttc tac acg act gag ccg agg      576
Tyr Leu His Ser Gly Asp Ser Ser Asp Phe Tyr Thr Thr Glu Pro Arg         
            180                 185                 190                 

aag act aat ccg gag aac gtg ctt cac ctg aag aag gtg act ggt cta      624
Lys Thr Asn Pro Glu Asn Val Leu His Leu Lys Lys Val Thr Gly Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ctg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gaa tca ggc tct tgt gat tat ttg act ggc cag gtg ctt tgc ttg cca      720
Glu Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Leu Cys Leu Pro         
225                 230                 235                 240         

ggc ggc ttt ccc ctg ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Leu Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  702
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  702

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Lys Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Gly 
            100                 105                 110         


Asn Ala Gly Ala Ser Gln Met Lys Asn Gln Lys Thr Val His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Ala Ser Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


His Thr Ser Ala Arg Ala Gly Gly Cys Thr Leu Thr Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Met Pro Glu Leu Ala Ile Glu Ala Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Ser Asp Phe Tyr Thr Thr Glu Pro Arg 
            180                 185                 190         


Lys Thr Asn Pro Glu Asn Val Leu His Leu Lys Lys Val Thr Gly Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Glu Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Leu Cys Leu Pro 
225                 230                 235                 240 


Gly Gly Phe Pro Leu Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  703
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  703
atg agc acc gct atc gtc act aac gtc aaa cat ttt ggt ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg ccg tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag aac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu Asn Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  704
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  704

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu Asn Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  705
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  705
atg agc acc gct atc gtc acc aac gtc aaa cat ttc gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cac aaa gat gat ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Lys Asp Asp Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gcc gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc cag gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Gln Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg tct act ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ser Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg agc gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac atg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Met Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag atg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Met Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  706
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  706

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Asp Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Gln Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ser Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Met Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Met Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  707
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  707
atg agc acc gct atc gtc acc aat gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cac aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gac aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aaa cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg cca cgg aaa gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Arg Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cgg gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac atg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Met Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc cta ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Leu Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  708
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  708

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Arg Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Met Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Leu Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  709
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  709
atg agc acc gct atc gtc act aac gtc aaa cat ttt ggt ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg ccg tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac atg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Met Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  710
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  710

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Met Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  711
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  711
atg agc acc gct atc gtc act aac gtc aaa cat ttt ggt ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg ccg tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag ctg ggt aag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Lys Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac atg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Met Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  712
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  712

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Lys Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Met Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  713
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  713
atg agc acc gct atc gtc act aac gtc aaa cat ttt ggt ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct ctg atg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Met         
            100                 105                 110                 

aat gct gtg act tct caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Thr Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg ccg tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac atg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Met Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  714
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  714

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Met 
            100                 105                 110         


Asn Ala Val Thr Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Met Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  715
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  715
atg agc acc gtc atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Val Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt ctg acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly Leu Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac atg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Met Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg acc      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Thr         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  716
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  716

Met Ser Thr Val Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly Leu Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Met Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Thr 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  717
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  717
atg agc acc gcc att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gct gct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Ala Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa gaa gag ttg ggg gaa ttg gtg aca ttt ttg      672
Gln Arg Leu Gly Thr Gln Glu Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc gga ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  718
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  718

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Ala Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Glu Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  719
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  719
atg agc acc gct acc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Thr Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ctg cgt cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Leu Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ctg ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Leu Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa gaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Glu Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag ctg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Leu Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttc ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  720
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  720

Met Ser Thr Ala Thr Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Leu Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Leu Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Glu Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Leu Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  721
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  721
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc cag gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Gln Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct agt ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ser Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt tcc cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Ser Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa gaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Glu Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  722
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  722

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Gln Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ser Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Ser Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Glu Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  723
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  723
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gcg ttt gcc gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aga tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Arg Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act tct ctg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Leu Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa gaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Glu Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg aca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Thr         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  724
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  724

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Arg Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Leu Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Glu Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Thr 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  725
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  725
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg atc cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cag gtc gat gta ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc tat cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Tyr Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ctg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg aca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Thr         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  726
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  726

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Tyr Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Thr 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  727
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(765)

<400>  727
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gct ccg ttc ggg cca tgg aaa gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttc ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa          765
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  728
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  728

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  729
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  729
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  730
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  730

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  731
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  731
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg cgt cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Arg Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gct gct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Ala Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag att aat ccg gag cac gtg act cac gtg cgt aag gtg act gct cta      624
Lys Ile Asn Pro Glu His Val Thr His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  732
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  732

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Arg Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Ala Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Ile Asn Pro Glu His Val Thr His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  733
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  733
atg agc acc gct att gtc acg aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aaa gat gaa ctg gaa gct ttt gct gac gcc tac      144
Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Asp Ala Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gct gct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Ala Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc cgc cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  734
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  734

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Lys Asp Glu Leu Glu Ala Phe Ala Asp Ala Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Ala Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  735
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  735
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gct gct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Ala Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg aca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  736
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  736

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Ala Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  737
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  737
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aag gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Lys Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca cgt aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gta gac aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Val Asp Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  738
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  738

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Lys Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Val Asp Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  739
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(774)

<400>  739
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct act ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt act cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 

gga tcc                                                              774
Gly Ser                                                                 
255                                                                     


<210>  740
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  740

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Thr Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Thr Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  741
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(765)

<400>  741
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc cag gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Gln Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gct ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt tcc cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Ser Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa          765
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  742
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  742

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Gln Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Ser Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  743
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(765)

<400>  743
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat caa ctg aaa gct ttt gct aaa acc tac      144
Glu Ser Phe Lys His Gln Asp Gln Leu Lys Ala Phe Ala Lys Thr Tyr         
        35                  40                  45                      

cca cag ctg atc cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cag gtc gat gta ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc tat cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Tyr Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ctg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg aca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Thr         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa          765
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  744
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  744

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Gln Leu Lys Ala Phe Ala Lys Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Tyr Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Thr 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  745
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  745
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  746
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  746

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  747
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  747
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  748
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  748

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  749
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  749
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc gac acc ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Asp Thr Pro Glu                 
                245                 250                                 


<210>  750
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  750

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Asp Thr Pro Glu 
                245                 250                 


<210>  751
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  751
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atc agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc act agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggc atg gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Gly Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt acc ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  752
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  752

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  753
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  753
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc gac acc ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Asp Thr Pro Glu                 
                245                 250                                 


<210>  754
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  754

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Asp Thr Pro Glu 
                245                 250                 


<210>  755
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  755
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc act agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttc gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt acc ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  756
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  756

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  757
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  757
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc act agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gac atg gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag gag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt acc ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc tcc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Ser Met Pro Glu                 
                245                 250                                 


<210>  758
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  758

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Ser Met Pro Glu 
                245                 250                 


<210>  759
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  759
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggc atg gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Gly Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt acc ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc gag atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Glu Met Pro Glu                 
                245                 250                                 


<210>  760
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  760

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Glu Met Pro Glu 
                245                 250                 


<210>  761
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  761
atg agc acc gct att gtc acc aac gtc aag cat tat gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Tyr Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atc agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc act agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gac atg gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc tcc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Ser Met Pro Glu                 
                245                 250                                 


<210>  762
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  762

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Tyr Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Ser Met Pro Glu 
                245                 250                 


<210>  763
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  763
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cct ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Pro Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atc agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc act agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gac atg gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag gag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt acc ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggt ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  764
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  764

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Pro Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  765
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant HHDH


<220>
<221>  CDS
<222>  (1)..(768)

<400>  765
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc act agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gcg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag gag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  766
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  766

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  767
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  767
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atc agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc act agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag gag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt acc ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  768
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  768

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  769
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  769
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc act agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag gag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ctg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  770
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  770

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  771
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  771
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atc agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gtt gtc act agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Val Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag gag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt acc ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc tcc gtg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Ser Val Pro Glu                 
                245                 250                                 


<210>  772
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  772

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Val Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Ser Val Pro Glu 
                245                 250                 


<210>  773
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  773
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atc agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc act agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggc atg gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Gly Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc gag gtg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Glu Val Pro Glu                 
                245                 250                                 


<210>  774
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  774

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Glu Val Pro Glu 
                245                 250                 


<210>  775
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  775
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gag cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atc agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc act agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  776
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  776

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  777
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  777
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc act agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt acc ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  778
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  778

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  779
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  779
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gac atg gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag gag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  780
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  780

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  781
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  781
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct atg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Met Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atc agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  782
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  782

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Met Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  783
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  783
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt atg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Met Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atc agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggc atg gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Gly Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc gag atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Glu Met Pro Glu                 
                245                 250                                 


<210>  784
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  784

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Met Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Glu Met Pro Glu 
                245                 250                 


<210>  785
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  785
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atc agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc act agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggc acg gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag gag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt acc ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  786
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  786

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  787
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  787
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc act agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt acc ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc tcc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Ser Met Pro Glu                 
                245                 250                                 


<210>  788
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  788

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Ser Met Pro Glu 
                245                 250                 


<210>  789
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  789
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atc agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc act agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggc acg gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag gag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt acc ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc tcc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Ser Met Pro Glu                 
                245                 250                                 


<210>  790
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  790

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Ser Met Pro Glu 
                245                 250                 


<210>  791
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  791
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atc agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

agt gcc gtc gct tcg caa atg aag gag cga aag tcg ggg cac atc atc      384
Ser Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt acc ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  792
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  792

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Ser Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  793
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  793
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atc agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc act agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggc acg gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  794
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  794

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  795
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant HHDH


<220>
<221>  CDS
<222>  (1)..(768)

<400>  795
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc act agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggc atg gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Gly Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag gag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt acc ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggg atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  796
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  796

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  797
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  797
atg agc acc gct att gtc tcc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Ser Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct atg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Met Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atc agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt acc ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc tcc gtg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Ser Val Pro Glu                 
                245                 250                                 


<210>  798
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  798

Met Ser Thr Ala Ile Val Ser Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Met Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Ser Val Pro Glu 
                245                 250                 


<210>  799
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  799
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc act agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt acc ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc tcc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Ser Met Pro Glu                 
                245                 250                                 


<210>  800
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  800

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Ser Met Pro Glu 
                245                 250                 


<210>  801
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  801
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atc agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc act agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gac acg gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac acg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cgg cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt acc ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc gag atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Glu Met Pro Glu                 
                245                 250                                 


<210>  802
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  802

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Glu Met Pro Glu 
                245                 250                 


<210>  803
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  803
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atc agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc act agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag gag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc acc tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt acc ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  804
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  804

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  805
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  805
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc act agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt atg gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Gly Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc gag atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Glu Met Pro Glu                 
                245                 250                                 


<210>  806
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  806

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Glu Met Pro Glu 
                245                 250                 


<210>  807
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  807
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cct atc agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc act agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggc atg gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Gly Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag gag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac acg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  808
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  808

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  809
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  809
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc act agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggc atg gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Gly Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag gag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt acc ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc tcc gtg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Ser Val Pro Glu                 
                245                 250                                 


<210>  810
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  810

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Ser Val Pro Glu 
                245                 250                 


<210>  811
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  811
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cct ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Pro Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atc agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc act agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt acc ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  812
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  812

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Pro Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  813
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  813
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc act agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggc atg gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Gly Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag gag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  814
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  814

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  815
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  815
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc act agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gac acg gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggg gtg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Val Pro Glu                 
                245                 250                                 


<210>  816
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  816

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Val Pro Glu 
                245                 250                 


<210>  817
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  817
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc act agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gac acg gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc tcc gtg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Ser Val Pro Glu                 
                245                 250                                 


<210>  818
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  818

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Ser Val Pro Glu 
                245                 250                 


<210>  819
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  819
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atc agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag gag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gct tct ggc tct tgt gat tat ttg act ggc cag gtg ttt acc ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  820
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  820

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  821
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  821
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggc acg gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag gag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt acc ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc tcc gtg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Ser Val Pro Glu                 
                245                 250                                 


<210>  822
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  822

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Ser Val Pro Glu 
                245                 250                 


<210>  823
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  823
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc act agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttc gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct ccg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Pro Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc tcc gtg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Ser Val Pro Glu                 
                245                 250                                 


<210>  824
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  824

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Pro Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Ser Val Pro Glu 
                245                 250                 


<210>  825
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  825
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc act agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gac acg gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt acc ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggg gtg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Val Pro Glu                 
                245                 250                                 


<210>  826
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  826

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Val Pro Glu 
                245                 250                 


<210>  827
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  827
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atc agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc act agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag gag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt agg tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Arg Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt acc ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  828
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  828

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Arg Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  829
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  829
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atc agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gac acg gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt acc ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc tcc gtg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Ser Val Pro Glu                 
                245                 250                                 


<210>  830
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  830

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Ser Val Pro Glu 
                245                 250                 


<210>  831
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  831
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atc agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc act agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt acc ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  832
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  832

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  833
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  833
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atc agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc act agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gac atg gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag gag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt acc ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  834
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  834

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  835
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  835
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atc agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc act agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggc acg gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag gag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac acg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt acc ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggg gtg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Val Pro Glu                 
                245                 250                                 


<210>  836
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  836

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Val Pro Glu 
                245                 250                 


<210>  837
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  837
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggc atg gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Gly Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag gag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  838
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  838

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  839
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  839
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc tcc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Ser Met Pro Glu                 
                245                 250                                 


<210>  840
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  840

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Ser Met Pro Glu 
                245                 250                 


<210>  841
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  841
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atc agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggc atg gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Gly Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc tcc gtg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Ser Val Pro Glu                 
                245                 250                                 


<210>  842
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  842

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Ser Val Pro Glu 
                245                 250                 


<210>  843
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  843
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc act agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt atg gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Gly Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  844
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  844

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  845
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  845
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atc agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc act agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg acg ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc tcc gtg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Ser Val Pro Glu                 
                245                 250                                 


<210>  846
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  846

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Ser Val Pro Glu 
                245                 250                 


<210>  847
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  847
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg tgt atg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Cys Met Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc act agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggc acg gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag gag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc gag gtg ccc gaa tga tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Glu Val Pro Glu                 
                245                 250                                 


<210>  848
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  848

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Cys Met Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Glu Val Pro Glu 
                245                 250                 


<210>  849
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  849
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atc agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc act agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gac acg gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag gaa cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac acg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  850
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  850

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  851
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  851
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag gag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac acg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc gag gtg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Glu Val Pro Glu                 
                245                 250                                 


<210>  852
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  852

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Glu Val Pro Glu 
                245                 250                 


<210>  853
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  853
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atc agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc aat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asn Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggc atg gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Gly Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc tcc gtg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Ser Val Pro Glu                 
                245                 250                                 


<210>  854
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  854

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asn Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Ser Val Pro Glu 
                245                 250                 


<210>  855
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  855
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cct ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Pro Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc act agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag gag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac acg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc tcc gtg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Ser Val Pro Glu                 
                245                 250                                 


<210>  856
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  856

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Pro Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Ser Val Pro Glu 
                245                 250                 


<210>  857
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  857
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag gag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac acg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  858
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  858

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  859
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  859
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atc agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag gag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  860
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  860

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  861
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  861
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cct ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Pro Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc act agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggc acg gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag gag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac acg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt ttg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Leu Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  862
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  862

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Pro Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Leu Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  863
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  863
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc act agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag gag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac acg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt acc ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  864
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  864

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  865
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  865
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct gtg cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Val His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  866
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  866

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Val His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  867
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  867
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gaa ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Glu Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aac gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc gga cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gcg cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  868
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  868

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Glu Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  869
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  869
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct cag acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Gln Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc gcc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Ala Met Pro Glu                 
                245                 250                                 


<210>  870
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  870

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Gln Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Ala Met Pro Glu 
                245                 250                 


<210>  871
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  871
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt gtg cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Val His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga gag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Glu Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ctg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  872
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  872

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Val His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Glu Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  873
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  873
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg tcg atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Ser Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  874
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  874

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Ser Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  875
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  875
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

att gcg cct gtg gaa tgg agc cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Ser Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gcg tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  876
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  876

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Ser Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  877
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  877
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg ggt atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gly Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttt atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  878
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  878

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gly Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  879
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  879
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gac gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag acg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Thr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  880
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  880

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Thr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  881
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  881
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gtt gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gag gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  882
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  882

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  883
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  883
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac atg cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Met His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  884
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  884

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Met His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  885
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  885
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg aat cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Asn His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  886
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  886

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Asn His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  887
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  887
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt atc gaa cgt tgg ccc gag atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Glu Met Pro Glu                 
                245                 250                                 


<210>  888
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  888

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Glu Met Pro Glu 
                245                 250                 


<210>  889
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  889
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga ggg tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Gly Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc ctt ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Leu Pro Glu                 
                245                 250                                 


<210>  890
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  890

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Gly Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Leu Pro Glu 
                245                 250                 


<210>  891
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  891
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act ctc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Leu Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gcc gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  892
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  892

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Leu Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  893
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  893
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat gtt gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Val Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  894
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  894

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Val Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  895
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  895
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc att gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ile Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg gga gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  896
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  896

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ile Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  897
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  897
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct cgg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Arg Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  898
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  898

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Arg Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  899
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  899
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gaa tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg tcg      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ser         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  900
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  900

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ser 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  901
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  901
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggg       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc agc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Ser Met Pro Glu                 
                245                 250                                 


<210>  902
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  902

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Ser Met Pro Glu 
                245                 250                 


<210>  903
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  903
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag gtc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Val Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  904
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  904

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Val Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  905
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  905
atg agc acc gct att gtc acc aac gtc aaa cat ttt ggg ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat gcc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Ala Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg ttg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Leu         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag tta ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Leu Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc gac atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Asp Met Pro Glu                 
                245                 250                                 


<210>  906
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  906

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Ala Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Leu 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Leu Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Asp Met Pro Glu 
                245                 250                 


<210>  907
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  907
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gcg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  908
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  908

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  909
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  909
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cat gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His His Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  910
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  910

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His His Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  911
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  911
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct cca aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gat act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Asp Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  912
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  912

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Asp Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  913
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  913
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct acg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Thr Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg acc ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  914
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  914

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Thr Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  915
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  915
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa ccc gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc agc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Ser Met Pro Glu                 
                245                 250                                 


<210>  916
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  916

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Ser Met Pro Glu 
                245                 250                 


<210>  917
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  917
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc agt atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Ser Met Pro Glu                 
                245                 250                                 


<210>  918
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  918

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Ser Met Pro Glu 
                245                 250                 


<210>  919
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  919
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg tcg      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Ser         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  920
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  920

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Ser 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  921
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  921
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gag      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Glu         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  922
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  922

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Glu 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  923
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  923
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggc       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gag agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac acg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  924
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  924

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  925
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  925
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggt cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg cac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro His Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  926
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  926

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro His Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  927
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  927
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag ctc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cgt gct ggg gct agt gca ctc gcg aat gct ctc tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag ctg ggc gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg tgg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Trp Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  928
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  928

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Trp Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  929
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  929
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc ggc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Gly Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  930
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  930

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Gly Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  931
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  931
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc act agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct ata gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Ile Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  932
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  932

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Ile Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  933
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  933
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga atg tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Met Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc cgt atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Arg Met Pro Glu                 
                245                 250                                 


<210>  934
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  934

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Met Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Arg Met Pro Glu 
                245                 250                 


<210>  935
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  935
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc tac cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Tyr Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  936
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  936

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Tyr Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  937
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  937
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gcc ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag ctg tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gca ggg act agt gca ctt gca aat gct ctg tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag ctg ggt gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  938
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  938

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  939
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  939
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag ctg tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cgc gct ggg gct agt gcc ctt gcg aat gct ctt tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag ctg ggc gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag acc tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc gtc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  940
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  940

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  941
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  941
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat acg ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Thr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  942
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  942

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Thr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  943
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  943
atg agc acc gct att gtc acc aac gtc aaa cag ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys Gln Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa cta att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  944
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  944

Met Ser Thr Ala Ile Val Thr Asn Val Lys Gln Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  945
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  945
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt act gtc gaa gct ctg cag atc aag cca ttt gct cta gcg      336
Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca gac aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Asp Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca ctg gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg cgg      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Arg         
                165                 170                 175             

tac cta cac tca ggg aac tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asn Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act cag aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  946
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  946

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Asp Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Arg 
                165                 170                 175     


Tyr Leu His Ser Gly Asn Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  947
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  947
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gcc gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Ala Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  948
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  948

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Ala Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  949
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  949
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat cag gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Gln Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  950
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  950

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Gln Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  951
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  951
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag tta act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Leu Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  952
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  952

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Leu Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  953
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  953
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tat gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Tyr Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  954
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  954

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Tyr Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  955
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  955
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt aca ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  956
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  956

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  957
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  957
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag tgt      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Cys         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  958
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  958

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Cys 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  959
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  959
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg tca      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Ser         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc acc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Thr Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  960
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  960

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Ser 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Thr Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  961
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  961
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act atc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Ile Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gca cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg acc gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  962
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  962

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Ile Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  963
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  963
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg ggt gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Gly Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  964
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  964

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Gly Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  965
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  965
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tgc cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Cys Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tcc ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  966
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  966

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Cys Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  967
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  967
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt act gtc gaa gct ctg cag atc aag cca ttt gct cta gcg      336
Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca gac aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Asp Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg cgg      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Arg         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  968
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  968

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Asp Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Arg 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  969
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  969
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gaa      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Glu         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gcg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg tat gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Tyr Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  970
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  970

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Glu 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Tyr Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  971
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  971
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct tgt cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Cys Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gcc tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  972
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  972

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Cys Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  973
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  973
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ttg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tca gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct ttg tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tgc cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Cys Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg acc gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttc ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  974
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  974

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Cys Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  975
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  975
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga tcc tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Ser Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tcc tgt gat tat ttg act ggc cag gtg ttt cgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  976
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  976

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Ser Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  977
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  977
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat aca gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Thr Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  978
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  978

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Thr Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  979
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  979
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aga tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Arg Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag cca tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt cgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  980
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  980

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Arg Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  981
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  981
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc aac cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Asn Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  982
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  982

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Asn Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  983
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  983
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt gag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly Glu Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tat tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  984
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  984

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly Glu Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  985
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  985
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt tcg cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Ser His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  986
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  986

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Ser His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  987
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  987
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aca cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Thr Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agt gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag ctg tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cgt gct ggg gct agt gca ctt gcg aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  988
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  988

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Thr Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  989
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  989
atg agc acc gca att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tca gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct ttg tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tgc cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Cys Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttc ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  990
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  990

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Cys Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  991
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  991
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg ccc gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc aat tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Asn Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  992
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  992

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Asn Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  993
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  993
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat caa gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Gln Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  994
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  994

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Gln Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  995
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  995
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cta atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Leu Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg acc      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  996
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  996

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Leu Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  997
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  997
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag agt act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Ser Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  998
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  998

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Ser Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  999
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  999
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aat gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cat atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tca gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct ttg tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg aat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asn Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg gga gaa ttg gtg acg ttc ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1000
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1000

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asn Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1001
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1001
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gag gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag acg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Thr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1002
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1002

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Thr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1003
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1003
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag ctg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Leu Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1004
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1004

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Leu Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1005
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1005
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg act cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Thr Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1006
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1006

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Thr Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1007
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1007
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtt gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac acg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1008
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1008

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1009
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1009
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gac      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg tct      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Ser         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1010
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1010

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Ser 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1011
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1011
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta aat tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu Asn Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1012
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1012

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu Asn Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1013
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1013
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgc agg gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Arg Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1014
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1014

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Arg Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1015
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1015
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag aag      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Lys         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gca cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1016
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1016

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Lys 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1017
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1017
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat cag gtc gaa gct ctg cag atc aag cca ttt gct ctg gtg      336
Tyr Arg Asp Gln Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1018
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1018

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Gln Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1019
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1019
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg cat atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser His Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa caa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu Gln             
                245                 250                 255             


<210>  1020
<211>  255
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1020

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser His Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu Gln 
                245                 250                 255 


<210>  1021
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1021
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct acc acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Thr Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1022
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1022

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Thr Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1023
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1023
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gcg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Ala Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1024
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1024

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Ala Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1025
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1025
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac ata gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Ile Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1026
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1026

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Ile Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1027
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1027
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc ggc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Gly Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gaa      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Glu         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1028
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1028

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Gly Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Glu 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1029
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1029
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttt ggg cca tgg aag gag ctg tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc gtc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1030
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1030

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1031
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1031
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgc ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1032
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1032

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1033
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1033
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gga act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Gly Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1034
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1034

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Gly Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1035
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1035
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa ccg gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat tgt gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Cys Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta ggg gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1036
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1036

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Cys Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1037
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1037
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aac gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1038
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1038

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1039
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1039
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cac acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg cat cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu His Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1040
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1040

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu His Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1041
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1041
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat tta act ggc cag gtg ttt cgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1042
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1042

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1043
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1043
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gag cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct ccg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Pro Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc cca ttc ggg cca tgg aaa gag ctt tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gca ggg gct agt gca ctg gca aat gct ctg tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag ctg ggt gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1044
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1044

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Pro Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1045
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1045
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac acg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg acc caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1046
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1046

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1047
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1047
atg agc acc gct att gtc acc aac gtt tca cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Ser His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag aag      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Lys         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1048
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1048

Met Ser Thr Ala Ile Val Thr Asn Val Ser His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Lys 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1049
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1049
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct atc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Ile Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1050
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1050

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Ile Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1051
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1051
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac acg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgc aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1052
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1052

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1053
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1053
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca ata agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag cgg cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag ctt tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gca ggg gct agt gca ctg gca aat gct ctg tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag ctc ggt gag tac aat att ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1054
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1054

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1055
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1055
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gta gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ctg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1056
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1056

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1057
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1057
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc aac aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Asn Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt cgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1058
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1058

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Asn Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1059
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1059
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct aat gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Asn Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcc ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1060
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1060

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Asn Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1061
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1061
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gcg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca gac aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Asp Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg cgg      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Arg         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act cag aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1062
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1062

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Asp Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Arg 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1063
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1063
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gcg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Ala Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gag ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1064
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1064

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Ala Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1065
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1065
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag acg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Thr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1066
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1066

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Thr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1067
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1067
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat atg gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc caa gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1068
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1068

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1069
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1069
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg tcc cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Ser Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccc gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1070
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1070

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Ser Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1071
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1071
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggc       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gag agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac acg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1072
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1072

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1073
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1073
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggg atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga atg tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Met Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1074
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1074

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Met Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1075
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1075
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat gct gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag ctc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca ctg gcc aat gct ctt tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag ctg ggc gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1076
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1076

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1077
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1077
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat cag gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Gln Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1078
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1078

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Gln Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1079
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1079
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac ctg cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag cta act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Leu Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1080
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1080

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Leu Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1081
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1081
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga gag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Glu Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gcc gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gga act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Gly Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1082
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1082

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Glu Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Gly Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1083
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1083
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aca cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Thr Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg gat caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Asp Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1084
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1084

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Thr Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Asp Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1085
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1085
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gcg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Ala Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tac ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1086
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1086

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Ala Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1087
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1087
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat cag gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Gln Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttc ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1088
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1088

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Gln Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1089
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1089
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac acg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1090
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1090

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1091
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1091
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1092
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1092

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1093
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1093
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg acg      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Thr         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1094
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1094

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Thr 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1095
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1095
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gcg gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Ala Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1096
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1096

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Ala Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1097
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1097
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggc cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tca caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac atg cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Met His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1098
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1098

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Met His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1099
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1099
atg aca acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Thr Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gtg ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Val Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1100
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1100

Met Thr Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Val Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1101
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1101
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag acc tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1102
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1102

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1103
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1103
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1104
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1104

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1105
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1105
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1106
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1106

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1107
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1107
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gct ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tgt ttg gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Cys Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gcg gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Ala Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc gat atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Asp Met Pro Glu                 
                245                 250                                 


<210>  1108
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1108

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Cys Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Ala Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Asp Met Pro Glu 
                245                 250                 


<210>  1109
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1109
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1110
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1110

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1111
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1111
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1112
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1112

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1113
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1113
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgc cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1114
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1114

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1115
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1115
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1116
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1116

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1117
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1117
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1118
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1118

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1119
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1119
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1120
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1120

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1121
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1121
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1122
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1122

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1123
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1123
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1124
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1124

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1125
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1125
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1126
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1126

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1127
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1127
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1128
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1128

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1129
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1129
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1130
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1130

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1131
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1131
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1132
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1132

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1133
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1133
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tcc tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1134
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1134

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1135
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1135
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1136
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1136

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1137
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1137
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1138
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1138

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1139
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1139
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc gat atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Asp Met Pro Glu                 
                245                 250                                 


<210>  1140
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1140

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Asp Met Pro Glu 
                245                 250                 


<210>  1141
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1141
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1142
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1142

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1143
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1143
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1144
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1144

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1145
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1145
atg agc acc gca att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa ata tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Ile Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1146
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1146

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Ile Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1147
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1147
atg agc acc gca att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gaa gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gac act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg aag tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Lys Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac ctg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Leu Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt ata gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1148
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1148

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Lys Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Leu Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1149
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1149
atg agc acc gcc att atc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Ile Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gcc ttg tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg acc gcc cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttc ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1150
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1150

Met Ser Thr Ala Ile Ile Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1151
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1151
atg agc acc gcc att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agt gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cgt gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly Arg Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ctg atc act tcg gct gcc ccg ttc ggg cca tgg aag gag ctc tcg act      432
Leu Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1152
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1152

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly Arg Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Leu Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1153
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1153
atg agc acc gcc att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct ttg tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg gat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asp         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttc ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1154
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1154

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asp 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1155
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1155
atg agc acc gct act gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Thr Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt ata gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1156
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1156

Met Ser Thr Ala Thr Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1157
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1157
atg agc acc gct act gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Thr Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cgt gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly Arg Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca cgt aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gtg gat aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Val Asp Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gcg      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1158
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1158

Met Ser Thr Ala Thr Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly Arg Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Val Asp Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1159
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1159
atg agc acc gct atc gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg agg ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cag aaa gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aaa cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct tac ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc ttt gct cca gaa ttt cag cca atc gat aaa tac gct gtc cag gat      288
Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Gln Asp         
                85                  90                  95              

tac agg ggt gct gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtg gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gct ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct tgt tcc cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Cys Ser Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc ggg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn         
                165                 170                 175             

tac cta cac tcg gag gat tcg ccg tac ttc tac ccg act gag ccg tgg      576
Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act aat ccg gag cac gtg gct cac gtg aag aag gtg act gct cta      624
Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1160
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1160

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys Gln Lys Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Lys Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Tyr Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Phe Ala Pro Glu Phe Gln Pro Ile Asp Lys Tyr Ala Val Gln Asp 
                85                  90                  95      


Tyr Arg Gly Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Cys Ser Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Gly Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Glu Asp Ser Pro Tyr Phe Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Asn Pro Glu His Val Ala His Val Lys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1161
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1161
atg agc acc gct att gta acc aac gtc aaa cat ttt gga ggt atg ggc       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gtt cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Val Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agt gaa cag gag cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt agt cgt gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Ser Arg Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct tgg gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Trp Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ctg atc act tcg gct gcc ccg ttc ggg cca tgg aag gag atc tcg act      432
Leu Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg aac tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asn Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1162
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1162

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Val Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Ser Arg Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Trp Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Leu Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asn Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1163
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1163
atg agc acc gct att gtc acc aaa gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Lys Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt act gtc gaa gct ctg cag atc aag cca ttt gct cta gcg      336
Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ctg atc acc tcg gct gcc ccg ttc ggg cca gac aag gag atc tcg act      432
Leu Ile Thr Ser Ala Ala Pro Phe Gly Pro Asp Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg cgg      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Arg         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1164
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1164

Met Ser Thr Ala Ile Val Thr Lys Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Leu Ile Thr Ser Ala Ala Pro Phe Gly Pro Asp Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Arg 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1165
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1165
atg agc acc gct att gtc acc aac gcc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Ala Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1166
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1166

Met Ser Thr Ala Ile Val Thr Asn Ala Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1167
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1167
atg agc acc gct att gtc acc aac gta aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tca ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca gac aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Asp Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg agg      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Arg         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1168
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1168

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Asp Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Arg 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1169
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1169
atg agc acc gct att gtc acc aac gtc aaa cac ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1170
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1170

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1171
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1171
atg agc acc gct att gtc acc aac gtc aaa cag ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys Gln Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

ccc cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca aag aag gag att tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Lys Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tat aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac tcg ggg gat tcg cca tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aag gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1172
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1172

Met Ser Thr Ala Ile Val Thr Asn Val Lys Gln Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Lys Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1173
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1173
atg agc acc gct att gtc acc aac gtc aaa cat ctt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Leu Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gac cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Asp Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1174
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1174

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Leu Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Asp Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1175
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1175
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggg atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1176
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1176

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1177
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1177
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gcg ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1178
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1178

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1179
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1179
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgc ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc att      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca aag aag gag att tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Lys Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac tcg ggg gac tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa gag gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Glu Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1180
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1180

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Lys Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Glu Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1181
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1181
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgc ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cgt gtc gat gtc ctg gtc tcc aac gat      240
Ala Val Thr Ser Ala Leu Gly Arg Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gac gtc ggg gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Asp Val Gly Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aac gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca cgt aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac gct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag gat aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Glu Asp Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1182
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1182

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly Arg Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Asp Val Gly Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Asp Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1183
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1183
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gcc ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtt gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1184
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1184

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1185
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1185
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gcc ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gat cag gag cca gct gaa ctg gtt gaa      192
Pro Gln Leu Ile Pro Met Ser Asp Gln Glu Pro Ala Glu Leu Val Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aac gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca cgt aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac agt tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttc cta cac tcg atc gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu His Ser Ile Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1186
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1186

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Asp Gln Glu Pro Ala Glu Leu Val Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu His Ser Ile Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1187
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1187
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggc cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1188
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1188

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1189
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1189
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggc cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag ctc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg aac tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asn Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1190
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1190

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asn Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1191
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1191
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gca tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1192
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1192

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1193
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1193
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gcc tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cga cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca gac aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Asp Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg agg      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Arg         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1194
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1194

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Asp Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Arg 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1195
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1195
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gcc tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggt act caa aaa gag tta ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1196
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1196

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1197
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1197
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gcg tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa aga gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Arg Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1198
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1198

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Arg Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1199
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1199
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gac       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gga cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Gly Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tgg tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Trp Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc gtg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Val Pro Glu                 
                245                 250                                 


<210>  1200
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1200

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Gly Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Trp Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Val Pro Glu 
                245                 250                 


<210>  1201
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1201
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

att agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Ile Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1202
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1202

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Ile Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1203
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1203
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aaa cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca gac aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Asp Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1204
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1204

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Asp Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1205
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1205
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat caa ctg aaa gct ttt gct aaa acc tac      144
Glu Ser Phe Lys His Gln Asp Gln Leu Lys Ala Phe Ala Lys Thr Tyr         
        35                  40                  45                      

cca cag ctg atc cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cag gtc gat gta ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc tat cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Tyr Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tcg ttc ggg cca aac aag gag ctc tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Asn Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ctg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gcg tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgc ttg aca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Thr         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1206
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1206

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Gln Leu Lys Ala Phe Ala Lys Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Tyr Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Asn Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Thr 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1207
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1207
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat caa ctg aaa gct ttt gct aaa acc tac      144
Glu Ser Phe Lys His Gln Asp Gln Leu Lys Ala Phe Ala Lys Thr Tyr         
        35                  40                  45                      

cca cag ctg atc cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cag gtc gat gta ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc tat cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Tyr Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtt gct tcg caa atg aag gac cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac ctg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Leu Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ctg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg aca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Thr         
225                 230                 235                 240         

ggc ggc ttt ccc gca gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Ala Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1208
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1208

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Gln Leu Lys Ala Phe Ala Lys Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Tyr Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Leu Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Thr 
225                 230                 235                 240 


Gly Gly Phe Pro Ala Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1209
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1209
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa agc ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ser Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc act ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Thr Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1210
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1210

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ser Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Thr Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1211
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1211
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gcc ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ctc ggg cca tgg aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Leu Gly Pro Trp Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg aac tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asn Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1212
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1212

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Leu Gly Pro Trp Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asn Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1213
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1213
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt act gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Thr Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac ctg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Leu Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gct ata gac cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Ala Ile Asp Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1214
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1214

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Thr Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Leu Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ala Ile Asp Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1215
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1215
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gcc gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1216
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1216

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1217
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1217
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gcc gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gac gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Asp Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc gtc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Val Met Pro Glu                 
                245                 250                                 


<210>  1218
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1218

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Asp Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Val Met Pro Glu 
                245                 250                 


<210>  1219
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1219
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct aaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Lys Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1220
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1220

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Lys Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1221
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1221
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct agt acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Ser Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc att      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1222
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1222

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Ser Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1223
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1223
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca act gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Thr Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1224
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1224

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Thr Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1225
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1225
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca cat gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro His Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg act agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1226
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1226

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro His Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1227
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1227
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gcc gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cag cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga tca ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ser Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1228
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1228

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ser Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1229
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1229
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gcc gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct tgg gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Trp Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1230
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1230

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Trp Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1231
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1231
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gca gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gac tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1232
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1232

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1233
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1233
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gcc gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1234
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1234

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1235
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1235
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gcc gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tcg ttc ggg cca tgg aag gag ctc tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg aac tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asn Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg aag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Lys His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1236
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1236

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asn Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Lys His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1237
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1237
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gcg gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1238
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1238

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1239
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1239
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gcc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Ala Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag ggg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Gly Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1240
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1240

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Ala Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Gly Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1241
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1241
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gac atg gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt cgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1242
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1242

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1243
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1243
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aca agc gct ctt ggt cat gta gat gtt ctg gtg agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct ctg gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aac gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag ctg tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ctg gtg acg ttt ctc      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg cca ggc atg cct gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1244
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1244

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1245
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1245
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc agg ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Arg Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1246
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1246

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Arg Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1247
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1247
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc caa ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Gln Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aac gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc gac atg acc aaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Asp Met Thr Lys                 
                245                 250                                 


<210>  1248
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1248

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Gln Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Asp Met Thr Lys 
                245                 250                 


<210>  1249
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1249
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gca ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gcg tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1250
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1250

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1251
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1251
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cag cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gac act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gtt tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Val Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tat cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac ctg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Leu Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1252
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1252

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Val Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Leu Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1253
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1253
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gcg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc acc tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1254
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1254

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1255
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1255
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gcg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1256
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1256

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1257
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1257
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1258
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1258

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1259
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1259
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc cca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag ttc aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Phe Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1260
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1260

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Phe Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1261
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1261
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt act gtc gaa gct ctg cag atc aag cca ttt gct cta gcg      336
Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca gac aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Asp Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg cgg      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Arg         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act cag aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1262
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1262

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Asp Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Arg 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1263
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1263
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gct cct gag gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Glu Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gcc cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1264
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1264

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Glu Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1265
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1265
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gct cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gcc cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg aca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg aca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Thr         
225                 230                 235                 240         

ggc ggc ttt ccc gcc atc gaa cgt tgt ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Ala Ile Glu Arg Cys Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1266
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1266

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Thr 
225                 230                 235                 240 


Gly Gly Phe Pro Ala Ile Glu Arg Cys Pro Gly Met Pro Glu 
                245                 250                 


<210>  1267
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1267
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gct cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gcc cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg aca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Thr         
225                 230                 235                 240         

ggc ggc ttt ccc gct atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1268
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1268

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Thr 
225                 230                 235                 240 


Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1269
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1269
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gta gat gta ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct ctg gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aac gct gtc gct tcg caa atg aag aag cgt aag tct ggc cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag ctg tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ctg gtg acg ttt ctc      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1270
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1270

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1271
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1271
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gac gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gaa tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Glu Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1272
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1272

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Glu Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1273
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1273
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gac gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1274
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1274

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1275
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1275
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat aac ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Asn Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca gac aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Asp Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tcg tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg cgg      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Arg         
                165                 170                 175             

ttc cta gat tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act cag aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gct gta gac cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Ala Val Asp Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1276
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1276

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Asn Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Asp Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Arg 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ala Val Asp Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1277
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1277
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cag cca atc gat aaa tac gct gtc ggg gat      288
Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Gly Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1278
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1278

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Gly Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1279
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1279
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttc ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1280
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1280

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1281
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1281
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct gtc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Val Ala Pro Asn         
                165                 170                 175             

ttt cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac ctg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Leu Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1282
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1282

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Val Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Leu Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1283
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1283
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat atc ctg gtc tgc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Cys Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gac gtc ggg gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Asp Val Gly Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca cgt aag gag att tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gtg tat aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Val Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1284
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1284

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Cys Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Asp Val Gly Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Val Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1285
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1285
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gta ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc tat cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Tyr Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gac gct tcg caa agg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Asp Ala Ser Gln Arg Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca gac aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Asp Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ctg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg aca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Thr         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1286
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1286

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Tyr Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Asp Ala Ser Gln Arg Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Asp Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Thr 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1287
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1287
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc cta gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct ctg gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aac gct gtc gct tcg caa atg aag aag cgt aag tcc ggc cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gtt cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Val Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gcc cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gta      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Val         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg cca gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1288
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1288

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Val Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Val 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1289
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1289
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gac      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gga cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Gly Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1290
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1290

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Gly Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1291
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1291
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc acg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Thr Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg aac tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asn Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

gcc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Ala Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1292
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1292

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Thr Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asn Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Ala Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1293
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1293
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg ccc gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgg aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1294
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1294

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1295
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1295
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg ccc gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1296
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1296

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1297
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1297
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg ccg gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gcg ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Ala Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Tyr Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1298
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1298

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Ala Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Tyr Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1299
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1299
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cag cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1300
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1300

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1301
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1301
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgc cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1302
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1302

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1303
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1303
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca acc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Thr Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1304
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1304

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Thr Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1305
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1305
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca ata gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg aag tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Lys Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac ctg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Leu Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc ata gac cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Asp Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1306
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1306

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Lys Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Leu Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Asp Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1307
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1307
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gcc gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg caa atc aag cca ttt gct atc gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Ile Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tca tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1308
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1308

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Ile Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1309
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1309
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag act      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Thr         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1310
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1310

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Thr 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1311
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1311
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gag act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Glu Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1312
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1312

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Glu Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1313
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1313
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gcc ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1314
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1314

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1315
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1315
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gcc cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gtt tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Val Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tat cta cac tcg ggg gat tcg aag tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Lys Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac ctg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Leu Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1316
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1316

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Val Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Lys Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Leu Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1317
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1317
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gcg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca gac aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Asp Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg cgg      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Arg         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1318
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1318

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Asp Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Arg 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1319
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1319
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aac gct gtt gtt tcg caa atg aaa aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Val Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca aag aag gag ctt tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Lys Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac tcg ggg gat tcg aag tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Lys Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa gag gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Glu Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1320
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1320

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Val Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Lys Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Lys Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Glu Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1321
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1321
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aac gct gtt gtt tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Val Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca cgt aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac tcg ggg gat tcg cca tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg tgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Cys Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1322
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1322

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Val Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Cys Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1323
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1323
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aac gct gtt gtt tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Val Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca cgt aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tat aat atc ccg gtg tat gct atc gct ccg gag      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Tyr Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac tcg ggg gat tcg aag tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Lys Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gcc cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa gag gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Glu Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gac tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ctc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Leu Gly Met Pro Glu                 
                245                 250                                 


<210>  1324
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1324

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Val Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Tyr Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Lys Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Glu Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Leu Gly Met Pro Glu 
                245                 250                 


<210>  1325
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1325
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tcg ttc ggg cca aat aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Asn Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg aac tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asn Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc gtt ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Val Pro Glu                 
                245                 250                                 


<210>  1326
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1326

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Asn Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asn Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Val Pro Glu 
                245                 250                 


<210>  1327
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1327
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gcc tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1328
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1328

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1329
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1329
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gcc tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc cct ttc ggg cca tgg aag gag ctg tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gca ggg gct agt gca ctt gca aat gct ctt tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag ctc ggt gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tcc ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1330
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1330

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1331
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1331
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct ccg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Pro Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag ctg tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca ctc gca aat gct ctt tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag ctc gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag cca tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1332
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1332

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Pro Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1333
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1333
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aaa aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca cgt aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tat aat atc ccg gtg tat gct atc gct ccg gag      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Tyr Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1334
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1334

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Tyr Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1335
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1335
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag ggt ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Gly Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1336
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1336

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Gly Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1337
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1337
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ctg atc act tcg gct gcc ccg ttc ggg cca tgg agg gag cta tcg act      432
Leu Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Arg Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg aac tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asn Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt cca gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1338
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1338

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Leu Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Arg Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asn Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1339
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1339
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ctg atc act tcg gct gcc tcg ttc ggg cca aat aag gag atc tcg act      432
Leu Ile Thr Ser Ala Ala Ser Phe Gly Pro Asn Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1340
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1340

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Leu Ile Thr Ser Ala Ala Ser Phe Gly Pro Asn Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1341
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1341
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ctg atc act tcg gct gcc tcg ttc ggg cca tgg aag gag ctc tcg act      432
Leu Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg aac tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asn Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1342
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1342

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Leu Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asn Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1343
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1343
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc acc tcg gct gcc ccg ttc ggg cca tgg aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg cgg      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Arg         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1344
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1344

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Arg 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1345
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1345
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tca gct gcc ccg ttc ggg cca tgt aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Cys Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct ttg tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tat tat tac ccc tct gag cca tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgg tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1346
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1346

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Cys Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1347
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1347
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc cca ttc ggg cca tgg aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg aac tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asn Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1348
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1348

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asn Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1349
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1349
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca aag aag gag att tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Lys Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac tcg ggg gat tcg cca tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aag gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1350
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1350

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Lys Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1351
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1351
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca aag aag gag ctt tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Lys Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tat aat atc acg gtg tat gct atc gct ccg gag      528
Lys Glu Leu Gly Glu Tyr Asn Ile Thr Val Tyr Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac tcg ggg gat tcg cca tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1352
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1352

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Lys Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Thr Val Tyr Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1353
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1353
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca aat aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Asn Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg aac tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asn Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1354
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1354

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Asn Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asn Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1355
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1355
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca aat aag gag ctc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Asn Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg aac tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asn Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc gtt ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Val Pro Glu                 
                245                 250                                 


<210>  1356
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1356

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Asn Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asn Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Val Pro Glu 
                245                 250                 


<210>  1357
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1357
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca cgt aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac tcg ggg gat tcg aag tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Lys Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1358
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1358

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Lys Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1359
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1359
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca cgt aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1360
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1360

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1361
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1361
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca cgt aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac gat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Glu Tyr Asp Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac tcg ggg gat tcg cca tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa gag gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Glu Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1362
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1362

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asp Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Glu Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1363
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1363
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca cgt aag gag att tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

gag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Glu Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aag gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tcc tgt gat tat ttg act ggc cag gtg ttt ggg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Gly Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc gac atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Asp Met Pro Glu                 
                245                 250                                 


<210>  1364
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1364

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Glu Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Gly Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Asp Met Pro Glu 
                245                 250                 


<210>  1365
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1365
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca cgt aag gag ctt tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac tcg ggg gat tcg aag tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Lys Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aag gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1366
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1366

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Lys Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1367
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1367
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca gac aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Asp Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg agg      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Arg         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1368
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1368

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Asp Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Arg 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1369
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1369
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca gac aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Asp Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg cgg      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Arg         
                165                 170                 175             

tac cta cac tcg ggg aac tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asn Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act cag aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1370
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1370

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Asp Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Arg 
                165                 170                 175     


Tyr Leu His Ser Gly Asn Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1371
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1371
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca gac aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Asp Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg cgg      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Arg         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act cag aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1372
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1372

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Asp Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Arg 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1373
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1373
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tat aag gag tgg tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Tyr Lys Glu Trp Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tac tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1374
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1374

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Tyr Lys Glu Trp Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1375
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1375
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tat aag gag ttg tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Tyr Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tac tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1376
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1376

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Tyr Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1377
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1377
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aaa gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1378
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1378

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1379
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1379
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg aac tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asn Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1380
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1380

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asn Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1381
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1381
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag cca tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1382
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1382

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1383
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1383
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tcg tcg gct cga gct ggg agt agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ser Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1384
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1384

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ser Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1385
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1385
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gca ggg gct agt gca ctg gca aat gct ctt tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag ctc ggt gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1386
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1386

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1387
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1387
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

gag act tct ccg gag cac gtg gct cac ctg cgt aag gtg act gct cta      624
Glu Thr Ser Pro Glu His Val Ala His Leu Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1388
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1388

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Glu Thr Ser Pro Glu His Val Ala His Leu Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1389
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1389
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg agt      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Ser         
                165                 170                 175             

tat cta cac tcg ggg gat tcg aag tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Lys Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac ctg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Leu Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt ata gac cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Asp Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1390
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1390

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Ser 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Lys Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Leu Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Asp Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1391
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1391
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gcc cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gct atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1392
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1392

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1393
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1393
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gcc cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gct atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1394
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1394

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1395
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1395
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gcc atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gag taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1396
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1396

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1397
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1397
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gcg ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgc tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1398
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1398

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1399
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1399
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

aac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Asn Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggt ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1400
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1400

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Asn Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1401
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1401
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcg cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1402
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1402

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1403
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1403
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg aac tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asn Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc tct ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Ser Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1404
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1404

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asn Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Ser Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1405
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1405
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg aac tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asn Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1406
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1406

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asn Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1407
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1407
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tac tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tat ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Tyr Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1408
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1408

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Tyr Pro Gly Met Pro Glu 
                245                 250                 


<210>  1409
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1409
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg cag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Gln His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1410
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1410

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Gln His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1411
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1411
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gcc cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1412
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1412

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1413
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1413
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac ctg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Leu Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gct ata gac cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Ala Ile Asp Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1414
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1414

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Leu Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ala Ile Asp Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1415
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1415
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg acc caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1416
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1416

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1417
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1417
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg acc caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1418
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1418

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1419
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1419
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ctg gtg acg ttt ctg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg cca ggc atg cct gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1420
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1420

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1421
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1421
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt tta      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1422
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1422

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1423
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1423
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tcc tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1424
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1424

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1425
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1425
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gta ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1426
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1426

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1427
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1427
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ctt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Leu Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1428
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1428

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Leu Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1429
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1429
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt cgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1430
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1430

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1431
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1431
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt ggt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Gly Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1432
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1432

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Gly Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1433
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1433
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ctg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1434
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1434

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1435
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1435
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

gga ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1436
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1436

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1437
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1437
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atg ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1438
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1438

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Met Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1439
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1439
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc att ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Ile Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1440
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1440

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ile Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1441
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1441
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc cgg ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Arg Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1442
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1442

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Arg Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1443
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1443
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc ctg ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Leu Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1444
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1444

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Leu Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1445
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1445
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gct ata gac cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Ala Ile Asp Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1446
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1446

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ala Ile Asp Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1447
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1447
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gct gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Ala Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1448
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1448

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ala Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1449
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1449
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc aac atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Asn Met Pro Glu                 
                245                 250                                 


<210>  1450
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1450

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Asn Met Pro Glu 
                245                 250                 


<210>  1451
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1451
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc atg ccc gaa taa tga tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Met Pro Glu                     
                245                 250                                 


<210>  1452
<211>  253
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1452

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Met Pro Glu 
                245                 250             


<210>  1453
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1453
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc cag atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gln Met Pro Glu                 
                245                 250                                 


<210>  1454
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1454

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gln Met Pro Glu 
                245                 250                 


<210>  1455
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1455
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc gag atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Glu Met Pro Glu                 
                245                 250                                 


<210>  1456
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1456

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Glu Met Pro Glu 
                245                 250                 


<210>  1457
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1457
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1458
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1458

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1459
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1459
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg cct ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1460
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1460

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1461
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1461
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc gtc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1462
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1462

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1463
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1463
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt ata gac cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Asp Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1464
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1464

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Asp Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1465
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1465
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt ata gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1466
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1466

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1467
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1467
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1468
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1468

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1469
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1469
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gac cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Asp Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1470
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1470

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Asp Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1471
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1471
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc ttg ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Leu Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1472
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1472

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Leu Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1473
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1473
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1474
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1474

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1475
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1475
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag ttg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Leu Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1476
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1476

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Leu Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1477
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1477
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggg tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1478
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1478

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1479
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1479
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggt tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1480
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1480

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1481
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1481
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gcc tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1482
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1482

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1483
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1483
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gcg tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1484
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1484

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1485
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1485
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gcg tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc gtt ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Val Pro Glu                 
                245                 250                                 


<210>  1486
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1486

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Val Pro Glu 
                245                 250                 


<210>  1487
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1487
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gct ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Ala Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1488
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1488

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Ala Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1489
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1489
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aag gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1490
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1490

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1491
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1491
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cat gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gct ata gac cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Ala Ile Asp Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1492
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1492

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ala Ile Asp Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1493
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1493
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag cga tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Arg Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1494
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1494

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Arg Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1495
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1495
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac tcc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Ser Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt ata gag cgt tgg ccc ggc atg ccc gaa tac tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu Tyr             
                245                 250                 255             


<210>  1496
<211>  255
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1496

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Ser Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu Tyr 
                245                 250                 255 


<210>  1497
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1497
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tat tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1498
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1498

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1499
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1499
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac ctg cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ctc gtg acg ttt ctc      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1500
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1500

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1501
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1501
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tat cta cac tcg ggg gat tcg acg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Thr Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac ctg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Leu Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt ata gac cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Asp Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1502
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1502

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Thr Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Leu Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Asp Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1503
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1503
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttc cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gcg      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1504
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1504

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1505
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1505
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac ctg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Leu Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gac cgt tgg ccc ggc gtg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Asp Arg Trp Pro Gly Val Pro Glu                 
                245                 250                                 


<210>  1506
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1506

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Leu Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Asp Arg Trp Pro Gly Val Pro Glu 
                245                 250                 


<210>  1507
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1507
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac tcg ggg gat tcg ccg tac tat cac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr His Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1508
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1508

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr His Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1509
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1509
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc ggt atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Gly Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1510
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1510

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Gly Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1511
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1511
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tat aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg acc caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1512
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1512

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1513
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1513
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tgc aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Cys Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1514
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1514

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Cys Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1515
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1515
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta ggg gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1516
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1516

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1517
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1517
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct tta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg aac tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asn Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gac tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1518
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1518

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asn Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1519
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1519
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cgc gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1520
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1520

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1521
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1521
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cgg gca ggg gct agt gca ctg gca aat gct ctg tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag ctg ggc gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1522
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1522

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1523
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1523
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cgt gct ggg gct agt gca ctg gca aat gct ctc tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag ctc ggt gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tcc ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1524
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1524

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1525
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1525
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg agc      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Ser         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1526
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1526

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Ser 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1527
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1527
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag ctc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg aac tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asn Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1528
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1528

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asn Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1529
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1529
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag ctg tcg acc      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca ctc gcc aat gct ctc tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag ctg ggt gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1530
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1530

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1531
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1531
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag ctg tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gca ggg gct agt gca ctg gca aat gct ctt tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag ctc ggt gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1532
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1532

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1533
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1533
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag ctg tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gca ggg gct agt gca ctt gca aat gct ctg tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag ctg ggt gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1534
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1534

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1535
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1535
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag ctg tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gca ggg gct agt gca ctt gca aat gct ctt tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag ctc ggt gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1536
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1536

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1537
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1537
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag ctg tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1538
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1538

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1539
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1539
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag ctg tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca ctt gcg aat gct ctt tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag ctg ggt gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1540
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1540

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1541
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1541
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag ctg tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cgt gct ggg gct agt gca ctt gca aat gct ctg tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag ctg ggt gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1542
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1542

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1543
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1543
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag ctt tcg aca      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cgc gct ggg gct agt gca ctc gcg aat gct ctg tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag ctg ggt gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1544
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1544

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1545
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1545
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag ctt tcg acc      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cgt gct ggg gct agt gcg ctt gca aat gct ctt tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag ctc ggt gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1546
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1546

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1547
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1547
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag ctt tcg acg      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cgc gct ggg gct agt gca ctg gca aat gct ctg tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag ctg ggc gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gcg tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1548
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1548

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1549
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1549
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag gga tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Gly Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gcg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Ala Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1550
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1550

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Gly Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Ala Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1551
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1551
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag tgg tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Trp Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tac tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gta gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tat ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Tyr Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1552
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1552

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Trp Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Tyr Pro Gly Met Pro Glu 
                245                 250                 


<210>  1553
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1553
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag ttg tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aac atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tac tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1554
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1554

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1555
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1555
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag ttg tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tac tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1556
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1556

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1557
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1557
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag ttg tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tac tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat ttt ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Phe Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1558
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1558

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Phe Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1559
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1559
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag ttg tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1560
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1560

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1561
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1561
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttt ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gag ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc aat ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Asn Pro Glu                 
                245                 250                                 


<210>  1562
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1562

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Asn Pro Glu 
                245                 250                 


<210>  1563
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1563
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tcg ttc ggg cca aat aag gag ctc tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Asn Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg aac tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asn Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1564
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1564

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Asn Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asn Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1565
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1565
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tcg ttc ggg cca tgg aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg aac tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asn Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1566
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1566

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asn Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1567
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1567
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tcg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc agc tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1568
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1568

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1569
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1569
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tcg ttc ggg cca tgg aag gag ctc tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg aac tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asn Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1570
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1570

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asn Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1571
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1571
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tcg ttc ggg cca tgg aag gag ctc tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg aac tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asn Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc gtt ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Val Pro Glu                 
                245                 250                                 


<210>  1572
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1572

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asn Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Val Pro Glu 
                245                 250                 


<210>  1573
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1573
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcg ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1574
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1574

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1575
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1575
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gct ccg ttc ggg cca tgt aag gag ttg tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Cys Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt agg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Arg Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1576
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1576

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Cys Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Arg Pro Gly Met Pro Glu 
                245                 250                 


<210>  1577
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1577
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga gag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Glu Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1578
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1578

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Glu Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1579
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1579
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aaa gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc tcg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Ser Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tat cta cac tcg ggg gat tcg aag tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Lys Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1580
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1580

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Ser Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Lys Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1581
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1581
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg cag atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1582
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1582

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1583
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1583
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat tct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ser Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1584
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1584

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ser Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1585
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1585
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

agt gct gtc gct ccg caa atg aag aag cga aag tcg ggg cac atc atc      384
Ser Ala Val Ala Pro Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag ctg tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cgc gct ggg gct agt gca ctg gcg aat gct ctg tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag ctg ggc gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1586
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1586

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Ser Ala Val Ala Pro Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1587
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1587
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct ctg gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aac gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1588
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1588

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1589
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1589
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct ctg gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aac gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cgc gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1590
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1590

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1591
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1591
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct ctg gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aac gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag ctc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac ctg cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg cca ggc atg cca gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1592
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1592

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1593
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1593
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct ctg gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aac gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag ctg tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cgt gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg cct ggc atg cca gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1594
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1594

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1595
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1595
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct ctg gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aac gct gtc gct tcg caa atg aag aag cgc aag tcc ggt cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1596
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1596

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1597
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1597
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct ctg gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aac gct gtc gct tcg caa atg aag aag cgt aag tcc ggt cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg cct ggc atg cct gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1598
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1598

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1599
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1599
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct ctg gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aac gct gtc gct tcg caa atg aag aag cgt aag tct ggc cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cgt gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac ctc cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ctg gtg acg ttt ctg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttc tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1600
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1600

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1601
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1601
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct ctg gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aac gct gtc gct tcg caa atg aag aag cgt aag tct ggt cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg cca ggc atg cct gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1602
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1602

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1603
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1603
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct ctg gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aac gct gtc gct tcg caa atg aag aag cgt aag tct ggt cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac ctt cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggt tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1604
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1604

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1605
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1605
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct ctg gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cgt aag tcc ggt cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag ctt tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac ctg cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1606
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1606

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1607
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1607
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct tgg gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Trp Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ctg atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Leu Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg aac tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asn Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1608
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1608

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Trp Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Leu Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asn Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1609
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1609
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct tgg gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Trp Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ctg atc act tcg gct gcc tcg ttc ggg cca tgg aag gag ctc tcg act      432
Leu Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg aac tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asn Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1610
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1610

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Trp Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Leu Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asn Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1611
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1611
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag ccg ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aaa aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca cgt aag gag att tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tat aat atc ccg gtg tat gct atc gct ccg gag      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Tyr Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac tcg ggg gat tcg cca tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1612
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1612

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Tyr Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1613
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1613
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag ctc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Leu Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg acg gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1614
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1614

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Leu Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1615
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1615
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg ctg atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Leu Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg cgg      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Arg         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1616
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1616

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Leu Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Arg 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1617
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1617
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg gta atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Val Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gcg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Ala Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg gcc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Ala Glu                 
                245                 250                                 


<210>  1618
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1618

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Val Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Ala Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Ala Glu 
                245                 250                 


<210>  1619
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1619
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa tca ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ser Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg gct      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Ala         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1620
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1620

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ser Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Ala 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1621
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1621
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gag gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag ctt tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cgc gct ggg gct agt gca ctg gct aat gct ctt tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag ctg ggc gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1622
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1622

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1623
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1623
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtt gaa gct ctg cag atc tgg cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Trp Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1624
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1624

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Trp Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1625
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1625
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtt gaa gct ctg cag atc ttt cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Phe Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1626
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1626

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Phe Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1627
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1627
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act ttg gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Leu Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1628
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1628

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Leu Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1629
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1629
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat gct gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1630
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1630

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1631
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1631
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat gct gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac ctg cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct ctc      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

cag cgt ctc ggt act caa aaa gag ttg ggg gaa ctc gtg acg ttt ctg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1632
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1632

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1633
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1633
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat gct gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

agg gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Arg Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttt ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1634
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1634

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Arg Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1635
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1635
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt act gtc gaa gct ctg cag atc aag cca ttt gct cta gcg      336
Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca gac aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Asp Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gcc atc gct ccg cgg      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Arg         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1636
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1636

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Asp Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Arg 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1637
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1637
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt act gtc gaa gct ctg cag atc aag cca ttt gct cta gcg      336
Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca gac aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Asp Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg cgg      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Arg         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgc aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1638
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1638

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Asp Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Arg 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1639
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1639
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt act gtc gaa gct ctg cag atc aag cca ttt gct cta gcg      336
Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca gac aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Asp Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg cgg      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Arg         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1640
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1640

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Asp Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Arg 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1641
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1641
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt act gtc gaa gct ctg cag atc aag cca ttt gct cta gcg      336
Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca gac aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Asp Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg cgg      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Arg         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act cag aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1642
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1642

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Asp Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Arg 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1643
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1643
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt act gtc gaa gct ctg cag atc aag cca ttt gct cta gcg      336
Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca gac aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Asp Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg cgg      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Arg         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act cag aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggt atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1644
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1644

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Asp Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Arg 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1645
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1645
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct aaa caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Lys Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1646
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1646

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Lys Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1647
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1647
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ctg atc acc tcg gct gcc ccg ttc ggg cca tgg aag gag atc tcg act      432
Leu Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act cag aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt aat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asn Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1648
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1648

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Leu Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asn Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1649
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1649
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act cag aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1650
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1650

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1651
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1651
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tat agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1652
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1652

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1653
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1653
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gca      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Ala         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg acc caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1654
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1654

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Ala 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1655
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1655
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag ggt      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Gly         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca gac aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Asp Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg cgg      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Arg         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act cag aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc gtt ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Val Pro Glu                 
                245                 250                                 


<210>  1656
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1656

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Gly 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Asp Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Arg 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Val Pro Glu 
                245                 250                 


<210>  1657
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1657
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc ggg gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Gly Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aac gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca cgt aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1658
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1658

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Gly Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1659
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1659
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc ggg gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Gly Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca cgt aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac agt ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1660
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1660

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Gly Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1661
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1661
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tgc gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Cys Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag gtg aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Val Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gag ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1662
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1662

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Cys Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Val Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1663
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1663
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tgc gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Cys Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca gac aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Asp Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg cgg      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Arg         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act cag aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1664
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1664

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Cys Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Asp Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Arg 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1665
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1665
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca att gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca gac aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Asp Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg agg      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Arg         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1666
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1666

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Asp Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Arg 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1667
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1667
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg ccg atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tat aag gag ttg tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Tyr Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta ggg gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tat ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Tyr Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1668
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1668

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Tyr Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Tyr Pro Gly Met Pro Glu 
                245                 250                 


<210>  1669
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1669
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg tca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Ser Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag aga tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Arg Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tat ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Tyr Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1670
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1670

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Ser Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Arg Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Tyr Pro Gly Met Pro Glu 
                245                 250                 


<210>  1671
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1671
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg ggc cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Gly Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1672
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1672

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Gly Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1673
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1673
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg tgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Trp Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac ctt cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct ctc      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

cag cgg ctt ggt act caa aaa gag ttg ggg gaa ctg gtg acg ttt ctc      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg cct ggc atg cct gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1674
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1674

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Trp Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1675
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1675
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gag tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1676
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1676

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1677
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1677
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gct cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gcc cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gct atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1678
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1678

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1679
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1679
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gtg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Val Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tgg tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Trp Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt cca gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1680
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1680

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Val Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Trp Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1681
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1681
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc tat cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Tyr Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca gac aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Asp Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg aca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Thr         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1682
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1682

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Tyr Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Asp Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Thr 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1683
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1683
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

att gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tcc tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1684
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1684

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1685
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1685
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

gtc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Val Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct aaa caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Lys Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1686
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1686

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Val Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Lys Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1687
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1687
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agt aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1688
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1688

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1689
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1689
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc tgc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Cys Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1690
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1690

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Cys Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1691
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1691
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtg agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1692
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1692

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1693
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1693
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtg agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct ctg gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aac gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg cca ggc atg cca gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1694
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1694

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1695
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1695
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ttg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag ctt tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cgc gct ggg gct agt gca ctg gcg aat gct ctt tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag ctg ggc gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1696
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1696

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1697
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1697
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ttg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc tat cct gtg gaa tgg cgg cca atc gat aaa tac gct ctc cag gat      288
Ile Tyr Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Leu Gln Asp         
                85                  90                  95              

tac agg ggt act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca gac aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Asp Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act cag aaa gag ctg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg aca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Thr         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1698
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1698

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Tyr Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Leu Gln Asp 
                85                  90                  95      


Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Asp Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Thr 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1699
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1699
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtg gat gta ctg gtg agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cga cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct ctg gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aac gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gcg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Ala Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg cct ggc atg cct gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1700
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1700

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Ala Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1701
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1701
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtg gat gtt ctg gtt agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cgc aag tct ggt cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ctg gtg acg ttt ctg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1702
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1702

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1703
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1703
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtt gat gtt ctg gta agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gag tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac cgt gat act gtc gaa gct ctg cag atc aag cca ttt gct ctg gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aac gct gtc gct tcg caa atg aag aag cgt aag tct ggt cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac ctg cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ctg gtg acg ttt ctg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg cca ggc atg cca gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1704
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1704

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1705
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1705
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtt gat gtt ctg gtg agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct ctg gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aac gct gtc gct tcg caa atg aag aag cgt aag tct ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag ctc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cgt gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac ctg cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ctc gtg acg ttt ctg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg cca ggc atg cct gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1706
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1706

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1707
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1707
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cgt gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly Arg Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca cgt aag gag att tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg aca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Thr         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1708
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1708

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly Arg Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Thr 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1709
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1709
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cgt gtc gat atc ctg gtc tgc aac gat      240
Ala Val Thr Ser Ala Leu Gly Arg Val Asp Ile Leu Val Cys Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gac gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Asp Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca cgt aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac gcc tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag gat aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Glu Asp Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1710
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1710

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly Arg Val Asp Ile Leu Val Cys Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Asp Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Asp Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1711
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1711
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt tta gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly Leu Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1712
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1712

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly Leu Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1713
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1713
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agt gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1714
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1714

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1715
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1715
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gtg gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Val Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

gtc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Val Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cgg cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tcc tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1716
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1716

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Val Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Val Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1717
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1717
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gag      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca cgt aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1718
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1718

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1719
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1719
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg gtt gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Val Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt agt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Ser His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cag cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt act gtc gaa gct ctg cag atc cgc cca ttt gct cta gtg      336
Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aac gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca cgt aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttc cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga ctt ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1720
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1720

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Val Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Ser His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1721
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1721
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gag ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gta gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg cca tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1722
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1722

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1723
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1723
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gga ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Gly Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tac tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt cct gtc atc gaa cgt agg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Arg Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1724
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1724

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Gly Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Arg Pro Gly Met Pro Glu 
                245                 250                 


<210>  1725
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1725
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gtt gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1726
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1726

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1727
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1727
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa ccg gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cag gtc gat gta ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc tat cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc ggg gat      288
Ile Tyr Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Gly Asp         
                85                  90                  95              

tac agg ggt act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cgg aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca gac aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Asp Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act cag aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1728
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1728

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Tyr Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Gly Asp 
                85                  90                  95      


Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Asp Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1729
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1729
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gag cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tcc ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1730
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1730

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1731
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1731
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gga cca gcc gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Gly Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cgt gtc gat gtc ctg gtc tgc aac gat      240
Ala Val Thr Ser Ala Leu Gly Arg Val Asp Val Leu Val Cys Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gcc gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg aat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asn Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gcc tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca cgt aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1732
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1732

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Gly Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly Arg Val Asp Val Leu Val Cys Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asn Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1733
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1733
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gga cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Gly Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag aaa tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Lys Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tac tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa tga tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1734
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1734

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Gly Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Lys Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1735
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1735
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gga cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Gly Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tac tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1736
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1736

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Gly Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1737
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1737
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gga cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Gly Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1738
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1738

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Gly Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1739
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1739
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gag cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gac act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag ctt tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gca ggg gct agt gca ctt gca aat gct ctt tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag ctg ggt gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1740
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1740

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1741
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1741
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gag cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tcc tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1742
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1742

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1743
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1743
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gag cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1744
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1744

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1745
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1745
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gag cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca att gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct ctg gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aac gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag ctg tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt atc gaa cgt tgg cct ggc atg cct gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1746
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1746

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1747
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1747
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gat cag gaa cca gct gaa ctg gtt gaa      192
Pro Gln Leu Ile Pro Met Ser Asp Gln Glu Pro Ala Glu Leu Val Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cag cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc cgc cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca cgt aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac agt tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tat aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag atg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Met Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gag ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1748
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1748

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Asp Gln Glu Pro Ala Glu Leu Val Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Met Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1749
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1749
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gat cag gaa cca gct gaa ctg gtt gaa      192
Pro Gln Leu Ile Pro Met Ser Asp Gln Glu Pro Ala Glu Leu Val Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cag cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc cgc cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc gtt act tcg gct gcc ccg ttc ggg cca cgt aag gag atc tcg act      432
Phe Val Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac tcc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Ser Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag atg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Met Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1750
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1750

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Asp Gln Glu Pro Ala Glu Leu Val Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Val Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Ser Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Met Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1751
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1751
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gat cag gaa cca gct gaa ctg gtt gaa      192
Pro Gln Leu Ile Pro Met Ser Asp Gln Glu Pro Ala Glu Leu Val Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cag cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca cgt aag gag att tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac agt tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag atg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Met Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gcg      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1752
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1752

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Asp Gln Glu Pro Ala Glu Leu Val Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Met Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1753
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1753
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agt gaa cag gag cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca gac aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Asp Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta ggg gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1754
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1754

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Asp Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1755
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1755
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg ggc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Gly Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctt cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1756
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1756

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Gly Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1757
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1757
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg ggc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Gly Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat gct gtt gaa gct ctg cag atc cgg cca ttt gct cta gtg      336
Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1758
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1758

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Gly Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1759
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1759
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca gtg agc gaa cag gaa cca gct gaa ctg att aaa      192
Pro Gln Leu Ile Pro Val Ser Glu Gln Glu Pro Ala Glu Leu Ile Lys         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aaa aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca cgt aag gag att tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gtg tat aat atc ccg gtg ttt gct atc gct ccg gag      528
Lys Glu Leu Gly Val Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa gag gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Glu Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt agg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Arg Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1760
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1760

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Val Ser Glu Gln Glu Pro Ala Glu Leu Ile Lys 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Val Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Glu Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Arg Pro Gly Met Pro Glu 
                245                 250                 


<210>  1761
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1761
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca gtg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Val Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aac gct gct gtt tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Ala Val Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca aag aag gag ctt tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Lys Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gtg tat aat atc acg gtg tat gct atc gct ccg gag      528
Lys Glu Leu Gly Val Tyr Asn Ile Thr Val Tyr Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgc tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1762
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1762

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Val Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Ala Val Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Lys Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Val Tyr Asn Ile Thr Val Tyr Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1763
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1763
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca gtg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Val Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aaa aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gcc gcc ccg ttc ggg cca aag aag gag ctt tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Lys Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1764
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1764

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Val Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Lys Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1765
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1765
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca gtg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Val Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca aag aag gag att tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Lys Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag gac aat atc ccg gtg ttt gct atc gct ccg gag      528
Lys Glu Leu Gly Glu Asp Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac tcg ggg gat tcg cca tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1766
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1766

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Val Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Lys Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Asp Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1767
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1767
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca gtg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Val Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca cgt aag gag att tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac tcg ggg gat tcg aag tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Lys Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aag gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1768
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1768

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Val Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Lys Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1769
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1769
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca gtg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Val Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca cgt aag gag ctt tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag gat aat atc acg gtg ttt gct atc gct ccg gag      528
Lys Glu Leu Gly Glu Asp Asn Ile Thr Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa gag gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Glu Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1770
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1770

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Val Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Asp Asn Ile Thr Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Glu Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1771
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1771
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca gtg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Val Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca cgt aag gag ctt tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttt gct atc gct ccg gag      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aag gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1772
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1772

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Val Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1773
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1773
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca gtg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Val Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1774
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1774

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Val Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1775
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1775
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca gtg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Val Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtt gtt tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Val Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca cgt aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa gag gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Glu Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1776
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1776

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Val Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Val Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Glu Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1777
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1777
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca gtg agc gaa cag gaa cca gct gaa ctg att gga      192
Pro Gln Leu Ile Pro Val Ser Glu Gln Glu Pro Ala Glu Leu Ile Gly         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca cgt aag gag att tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttt gct atc gct ccg gag      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac tcg ggg gat tcg cca tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc atc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Ile Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1778
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1778

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Val Ser Glu Gln Glu Pro Ala Glu Leu Ile Gly 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ile Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1779
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1779
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg atc cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc tct cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ser Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ctg ggg gaa ttg gtg aca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg aca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Thr         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1780
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1780

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ser Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Thr 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1781
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1781
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg cat cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu His Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gcc ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg aca caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1782
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1782

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu His Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1783
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1783
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cgg ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Arg Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct cct gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1784
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1784

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Arg Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1785
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1785
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

ccc cag ctg ata cca atg agc gaa cag gaa cca gct gaa cta att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1786
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1786

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1787
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1787
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tat      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag agg cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cgg gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1788
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1788

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1789
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1789
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa act tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca gtg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Val Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tcg ttc ggg cca aag aag gag att tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Lys Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1790
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1790

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Val Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Lys Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1791
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1791
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa act tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca gtg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Val Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tcg ttc ggg cca aat aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Asn Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1792
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1792

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Val Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Asn Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1793
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1793
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gag acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cgg gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1794
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1794

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1795
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1795
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gag gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gac acg gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aaa cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1796
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1796

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1797
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1797
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa ctc gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1798
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1798

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1799
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1799
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg atc cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc tat cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Tyr Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tat aag gag ttg tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Tyr Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ctg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg aca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Thr         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt agg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Arg Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1800
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1800

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Tyr Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Tyr Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Thr 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Arg Pro Gly Met Pro Glu 
                245                 250                 


<210>  1801
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1801
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa ctg gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg atc cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cag gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc tat cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Tyr Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgt aag gag ttg tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Cys Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tac tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ctg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg aca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Thr         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt ttt ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Phe Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1802
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1802

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Tyr Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Cys Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Thr 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Phe Pro Gly Met Pro Glu 
                245                 250                 


<210>  1803
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1803
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa gca gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Ala Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1804
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1804

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Ala Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1805
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1805
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gag cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1806
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1806

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1807
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1807
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gta ctg aaa gct ttt gct aaa acc tac      144
Glu Ser Phe Lys His Gln Asp Val Leu Lys Ala Phe Ala Lys Thr Tyr         
        35                  40                  45                      

cca cag ctg atc cca atg agt gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cag gtc gat gta ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc tat cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Tyr Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ctg atc act tcg gct gcc ccg ttc ggg cca aac aag gag cta tcg act      432
Leu Ile Thr Ser Ala Ala Pro Phe Gly Pro Asn Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ctg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgc ttg aca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Thr         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1808
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1808

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Val Leu Lys Ala Phe Ala Lys Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Tyr Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Leu Ile Thr Ser Ala Ala Pro Phe Gly Pro Asn Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Thr 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1809
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1809
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gtt cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Val Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt agt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Ser His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gag tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg aac tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asn Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1810
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1810

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Val Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Ser His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asn Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1811
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1811
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gtt cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Val Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct tgg gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Trp Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tcg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg aac tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asn Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1812
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1812

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Val Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Trp Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asn Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1813
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1813
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gtt cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Val Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agt gaa cag gag cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ctg atc acc tcg gct gcc ccg ttc ggg cca tgg aag gag atc tcg act      432
Leu Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1814
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1814

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Val Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Leu Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1815
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1815
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gtt cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Val Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agt gaa cag gag cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ttg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ctg atc act tcg gct gcc tcg ttc ggg cca tgg aag gag ctc tcg act      432
Leu Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc gtg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Val Pro Glu                 
                245                 250                                 


<210>  1816
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1816

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Val Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Leu Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Val Pro Glu 
                245                 250                 


<210>  1817
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1817
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gtt cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Val Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agt gaa cag gag cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cgt gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly Arg Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct tgg gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Trp Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ctg atc act tcg gct gcc tcg ttc ggg cca tgg aag gag cta tcg act      432
Leu Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac ata cac tcg ggg aac tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Ile His Ser Gly Asn Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gag ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1818
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1818

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Val Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly Arg Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Trp Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Leu Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Ile His Ser Gly Asn Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1819
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1819
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gtt cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Val Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agt gaa cag gag cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agt gct ctt agt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Ser His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct tgg gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Trp Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tcg ttc ggg cca tgg aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tcc aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Ser Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aac gag ttg ggg gaa tcg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Asn Glu Leu Gly Glu Ser Val Thr Phe Leu         
    210                 215                 220                         

gca tcc ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt tgg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Trp Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc gtt ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Val Pro Glu                 
                245                 250                                 


<210>  1820
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1820

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Val Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Ser His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Trp Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Ser Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Asn Glu Leu Gly Glu Ser Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Trp Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Val Pro Glu 
                245                 250                 


<210>  1821
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1821
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gtt cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Val Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agt gaa cag ggg cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Gly Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cgt gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly Arg Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ctg atc act tcg gct gcc ccg ttc ggg cca tgg aag gag ctc tcg act      432
Leu Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg aac tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asn Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg act cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Thr His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1822
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1822

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Val Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Gly Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly Arg Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Leu Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asn Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Thr His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1823
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1823
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gtt cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Val Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg ggt gaa cag gag cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Gly Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt agt cgt gtc gat gtc ctg gtt agc aac gat      240
Ala Val Thr Ser Ala Leu Ser Arg Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gga gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Gly Asp         
                85                  90                  95              

tac agg ggc act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tcg ttc ggg cca tgg aag gag ctc tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg aac tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asn Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc gtt ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Val Pro Glu                 
                245                 250                                 


<210>  1824
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1824

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Val Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Gly Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Ser Arg Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Gly Asp 
                85                  90                  95      


Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asn Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Val Pro Glu 
                245                 250                 


<210>  1825
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1825
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gtt cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Val Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca gtg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Val Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ctg atc act tcg gct gcc tcg ttc ggg cca aat aag gag atc tcg act      432
Leu Ile Thr Ser Ala Ala Ser Phe Gly Pro Asn Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg aac tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asn Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc gtg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Val Pro Glu                 
                245                 250                                 


<210>  1826
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1826

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Val Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Val Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Leu Ile Thr Ser Ala Ala Ser Phe Gly Pro Asn Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asn Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Val Pro Glu 
                245                 250                 


<210>  1827
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1827
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag ggt gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Gly Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cgt gtc gat atc ctg gtc tcc aac gat      240
Ala Val Thr Ser Ala Leu Gly Arg Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aac gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca cgt aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac agt ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1828
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1828

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Gly Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly Arg Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1829
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1829
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca cgt aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac agc ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1830
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1830

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1831
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1831
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agt ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag aaa tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Lys Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tac tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tat ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Tyr Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1832
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1832

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Lys Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Tyr Pro Gly Met Pro Glu 
                245                 250                 


<210>  1833
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1833
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agt ttt aag cat cag gat gta ctg aaa gct ttt gct aaa acc tac      144
Glu Ser Phe Lys His Gln Asp Val Leu Lys Ala Phe Ala Lys Thr Tyr         
        35                  40                  45                      

cca cag ctg atc cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cag gtc gat gta ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc tat cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Tyr Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca aac aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Asn Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ctg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgc ttg aca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Thr         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1834
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1834

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Val Leu Lys Ala Phe Ala Lys Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Tyr Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Asn Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Thr 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1835
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1835
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gag agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gta gat gta ctg gtt agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggt cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag ctg tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cgc gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ctc gtg acg ttt ctc      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1836
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1836

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1837
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1837
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gag agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aac gct gtt gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca aag aag gag att tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Lys Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1838
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1838

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Lys Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1839
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1839
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gag agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg caa atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly Gln Ile Ile         
        115                 120                 125                     

ttc atc act tca gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct ttg tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tat tat tat ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg acc gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttc ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1840
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1840

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly Gln Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1841
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1841
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gag agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tat aag gag ttg tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Tyr Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1842
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1842

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Tyr Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1843
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1843
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gag agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttc tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1844
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1844

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1845
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1845
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gag agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gct ata gac cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Ala Ile Asp Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1846
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1846

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ala Ile Asp Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1847
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1847
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gat agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Asp Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag ctg gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atc ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Ile Pro Glu                 
                245                 250                                 


<210>  1848
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1848

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Asp Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Ile Pro Glu 
                245                 250                 


<210>  1849
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1849
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc tat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys Tyr Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cgt gtc gat gtc ctg gtc tgc aac gat      240
Ala Val Thr Ser Ala Leu Gly Arg Val Asp Val Leu Val Cys Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aac gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca cgt aag gag att tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac agt ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1850
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1850

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys Tyr Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly Arg Val Asp Val Leu Val Cys Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1851
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1851
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gtc tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Val Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1852
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1852

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Val Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1853
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1853
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gtt tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Val Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1854
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1854

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Val Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1855
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1855
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat gcc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Ala Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca gtg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Val Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aaa aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca cgt aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac tcg ggg gat tcg cca tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa gag gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Glu Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1856
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1856

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Ala Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Val Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Glu Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1857
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1857
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg ggc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Gly Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg aag tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Lys Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gac cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Asp Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1858
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1858

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Gly Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Lys Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Asp Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1859
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1859
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg ggc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Gly Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1860
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1860

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Gly Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1861
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1861
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg tgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Cys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gag cgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Arg Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc gtt act tcg gct gcc ccg ttc ggg cca cgt aag gag atc tcg act      432
Phe Val Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tat aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag aac gtg gcc cac gtg cgt aag atg act gct cta      624
Lys Thr Ser Pro Glu Asn Val Ala His Val Arg Lys Met Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tcc tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1862
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1862

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Cys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Arg Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Val Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu Asn Val Ala His Val Arg Lys Met Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1863
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1863
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg tgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Cys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg gtt gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Val Glu         
    50                  55                  60                          

gcc gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cag cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gcc ctg cag atc cgc cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aac gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca cgt aag gag ctt tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac agt tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gtg tat aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Val Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag atg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Met Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1864
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1864

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Cys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Val Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Val Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Met Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1865
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1865
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg tgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Cys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg gtt gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Val Glu         
    50                  55                  60                          

gcc gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cag cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca cgt aag gag att tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttc cta cac tcg atc gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu His Ser Ile Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag atg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Met Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1866
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1866

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Cys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Val Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu His Ser Ile Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Met Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1867
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1867
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg tgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Cys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg gtt gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Val Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cag cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aac gct gtc gct tcg caa atg aag aag cga aag tca ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc gtt act tcg gct gcc ccg ttc ggg cca cgt aag gag atc tcg act      432
Phe Val Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag aac gtg gct cac gtg cgt aag atg act gct cta      624
Lys Thr Ser Pro Glu Asn Val Ala His Val Arg Lys Met Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1868
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1868

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Cys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Val Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Val Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu Asn Val Ala His Val Arg Lys Met Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1869
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1869
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg tgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Cys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg gtt gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Val Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cag cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca cgt aag gag ctt tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag gat aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Asp Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttc cta cac tcg atc gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu His Ser Ile Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gcg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1870
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1870

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Cys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Val Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Asp Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu His Ser Ile Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1871
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1871
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg tgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Cys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg gtt gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Val Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cag cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc gtt act tcg gct gcc ccg ttc ggg cca cgt aag gag att tcg act      432
Phe Val Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttc cta cac tcg atc gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu His Ser Ile Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1872
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1872

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Cys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Val Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Val Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu His Ser Ile Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1873
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1873
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg tgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Cys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg gtt gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Val Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc cgc cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc gtt act tcg gct gcc ccg ttc ggg cca cgt aag gag atc tcg act      432
Phe Val Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac agt tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag gat aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Glu Asp Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag atg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Met Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1874
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1874

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Cys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Val Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Val Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Asp Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Met Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1875
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1875
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg tgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Cys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa ccg gct gaa ctg gtt gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Val Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cag cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aac gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca cgt aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag atg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Met Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1876
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1876

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Cys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Val Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Met Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1877
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1877
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg tgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Cys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gat cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Asp Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cag cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aac gct atc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Ile Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca cgt aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag atg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Met Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1878
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1878

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Cys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Asp Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Ile Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Met Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1879
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1879
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg tgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Cys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gat cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Asp Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca att gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc cgc cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aac gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc gtt act tcg gct gcc ccg ttc ggg cca cgt aag gag atc tcg act      432
Phe Val Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1880
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1880

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Cys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Asp Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Val Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1881
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1881
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ttg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct tgg gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Trp Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tcg ttc ggg cca tgg aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1882
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1882

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Trp Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1883
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1883
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agt gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tcg ttc ggg cca tgg aag gag ctc tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1884
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1884

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1885
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1885
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agt gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca cgt aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac agt ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1886
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1886

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1887
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1887
atg agc acc gct att gtc acc aac gtc aaa cat ttt gga ggt gtg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Val Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1888
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1888

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Val Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1889
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1889
atg agc acc gct att gtc acc aac gtc aaa cat ttt ggg ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gcg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca gac aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Asp Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1890
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1890

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Asp Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1891
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1891
atg agc acc gct att gtc acc aac gtc aaa cat ttt ggg ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

tca gct gtc gct tcg caa atg aag aag cga aag tcg gga cac atc atc      384
Ser Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1892
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1892

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Ser Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1893
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1893
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt acg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Thr Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggc atg atc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Gly Met Ile Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gcg gtc gct tcg caa atg aag aaa cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1894
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1894

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Thr Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Met Ile Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1895
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1895
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg gga       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat att ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat atg gtc gaa gca ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gtc ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Val Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1896
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1896

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Val Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1897
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1897
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgc ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gcc gtc ggg gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Gly Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca cgt aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac gtc tcg gct cga gct ggg gct ggt gca cta gct aat gct cta tcg      480
Tyr Val Ser Ala Arg Ala Gly Ala Gly Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1898
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1898

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Gly Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Val Ser Ala Arg Ala Gly Ala Gly Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1899
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1899
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggc cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atc agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat gaa tac gcg gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Glu Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tct caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg aca      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag cac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu His Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ggt tgc gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Gly Cys Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg tta gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1900
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1900

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Glu Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu His Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Gly Cys Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1901
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1901
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggc cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gta gaa tgg cgg cca atc gat aaa tac gcc gtc ggg gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Gly Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aac gct gtc gct tcg caa atg aag gag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca cgt aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac gct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tat aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac agt ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1902
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1902

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Gly Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1903
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1903
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gcc tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gtt tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Val Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gct ata gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1904
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1904

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Val Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1905
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1905
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct cgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Arg His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cgt gtc gat gtc ctg gtc tgc aac gat      240
Ala Val Thr Ser Ala Leu Gly Arg Val Asp Val Leu Val Cys Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa cgg cgg cca atc gat aaa tac gac gtc ggg gat      288
Ile Ala Pro Val Glu Arg Arg Pro Ile Asp Lys Tyr Asp Val Gly Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aac gct gtc gct tcg caa atg aag gag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca cgt aag gag att tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac agt ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gta tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Val Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1906
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1906

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Arg His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly Arg Val Asp Val Leu Val Cys Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Arg Arg Pro Ile Asp Lys Tyr Asp Val Gly Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Val Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1907
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1907
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gac       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aga tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Arg Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc atg gac tcg ggg gat tcg ccg tac tat tac ccc tct gtg ccg tgg      576
Ala Met Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Val Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1908
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1908

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Arg Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Met Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Val Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1909
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1909
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gcc ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aac gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca cgt aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac agt ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1910
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1910

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1911
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1911
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttc gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atc agc gaa cag gaa cca gtg gaa ctg att gaa      192
Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc ggt atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Gly Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1912
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1912

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Gly Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1913
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1913
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttc gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gtg gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cgg cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1914
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1914

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1915
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1915
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atc agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg aat gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Asn Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt cgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1916
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1916

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Asn Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1917
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1917
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atc agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cgg gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttt gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Phe Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1918
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1918

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Phe Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1919
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1919
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atc agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat atg gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tct caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg aca      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag cac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu His Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gct tgc gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Cys Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttc gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Phe Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1920
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1920

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu His Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Cys Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Phe Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1921
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1921
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atc agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat gaa tac acg gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Glu Tyr Thr Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg aca      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag cac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu His Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ggt tgc gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Gly Cys Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gtt tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Val Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1922
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1922

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Glu Tyr Thr Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu His Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Gly Cys Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Val Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1923
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1923
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atc agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat gaa tac gcg gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Glu Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg aca      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag cac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu His Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ggt tgc gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Gly Cys Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttc gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Phe Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1924
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1924

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Glu Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu His Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Gly Cys Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Phe Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1925
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1925
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atc agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat gaa tac gcg gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Glu Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg aca      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc tgc gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Cys Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttc gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Phe Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1926
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1926

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Glu Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Cys Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Phe Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1927
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1927
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atc agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat gaa tac gcg gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Glu Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg aca      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ggt gtg gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Gly Val Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttc gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Phe Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1928
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1928

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Glu Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Gly Val Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Phe Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1929
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1929
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atc agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac acg gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Thr Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg aca      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag cac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu His Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gct tgc gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Cys Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttc gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Phe Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1930
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1930

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Thr Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu His Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Cys Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Phe Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1931
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1931
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atc agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gcg gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg aca      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag cac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu His Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gct gtg gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Val Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg tta gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1932
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1932

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu His Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Val Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1933
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1933
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atc agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gcg gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg aca      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag cac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu His Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ggc tgc gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Gly Cys Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1934
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1934

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu His Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Gly Cys Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1935
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1935
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atc agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gcg gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg aca      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag cac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu His Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ggt gtg gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Gly Val Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa gaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Glu Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt cgc ttc gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Phe Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1936
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1936

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu His Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Gly Val Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Glu Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Phe Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1937
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1937
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atc agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg aca      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ggt gtg gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Gly Val Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg gct ggc cag gtg ttt cgc tta gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Ala Gly Gln Val Phe Arg Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1938
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1938

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Gly Val Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Ala Gly Gln Val Phe Arg Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1939
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1939
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atc agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt cgt ttt gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Phe Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1940
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1940

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Phe Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1941
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1941
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atc agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttt gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Phe Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1942
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1942

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Phe Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1943
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1943
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atc agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc ggg gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Gly Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg aca      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gct atg gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Met Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt cgc tta gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1944
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1944

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Gly Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Met Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1945
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1945
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atc agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat gaa tac acg gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Glu Tyr Thr Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg aca      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag cac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu His Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ggc atg gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Gly Met Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ctt tgg tta gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Leu Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1946
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1946

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Glu Tyr Thr Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu His Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Gly Met Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Leu Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1947
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1947
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atc agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat gaa tac gcg gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Glu Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg aca      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag cac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu His Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gct tgc gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Cys Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tac ttg act ggc cag gtg ttt cgc tta gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1948
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1948

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Glu Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu His Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Cys Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1949
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1949
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atc agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat gaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Glu Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag ccg ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg aca      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag cac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu His Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ggc gtg gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Gly Val Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gta ttt tgg ttc gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Phe Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1950
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1950

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Glu Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu His Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Gly Val Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Phe Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1951
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1951
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atc agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc gtt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Val Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg aat gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Asn Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag ttg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Leu Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggg acg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Thr Pro Glu                 
                245                 250                                 


<210>  1952
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1952

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Val Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Asn Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Leu Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Thr Pro Glu 
                245                 250                 


<210>  1953
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1953
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atc agc gaa cag gaa cca gtg gaa ctg att gaa      192
Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg aat gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Asn Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt cgt ttt gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Phe Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1954
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1954

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Asn Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Phe Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1955
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1955
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atc agc gaa cag gaa cca gtg gaa ctg att gaa      192
Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg aat gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Asn Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1956
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1956

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Asn Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1957
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1957
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atc agc gaa cag gaa cca gtg gaa ctg att gaa      192
Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg aat gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Asn Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgt gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Cys Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttt gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Phe Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1958
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1958

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Asn Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Cys Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Phe Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1959
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1959
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atc agc gaa cag gaa cca gtg gaa ctg att gaa      192
Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt cgt ttt gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Phe Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1960
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1960

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Phe Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1961
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1961
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atc agc gaa cag gaa cca gtg gaa ctg att gaa      192
Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga gag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Glu Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1962
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1962

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Glu Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1963
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1963
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atc agc gaa cag gaa cca gtg gaa ctg att gaa      192
Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tca gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttt gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Phe Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1964
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1964

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Phe Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1965
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1965
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atc agc gaa cag gaa cca gtg gaa ctg att gaa      192
Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg aat gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Asn Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt cgt ttt gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Phe Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1966
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1966

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Asn Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Phe Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1967
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1967
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atc agc gaa cag gaa cca gtg gaa ctg att gaa      192
Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg aat gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Asn Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1968
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1968

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Asn Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1969
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1969
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atc agc gaa cag gaa cca gtg gaa ctg att gaa      192
Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg aat gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Asn Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc tct atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Ser Met Pro Glu                 
                245                 250                                 


<210>  1970
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1970

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Asn Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Ser Met Pro Glu 
                245                 250                 


<210>  1971
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1971
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atc agc gaa cag gaa cca gtg gaa ctg att gaa      192
Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttc ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt cgt ttt gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Phe Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1972
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1972

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Phe Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1973
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1973
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atc agc gaa cag gaa cca gtg gaa ctg att gaa      192
Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt cgt ttt gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Phe Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc gct atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Ala Met Pro Glu                 
                245                 250                                 


<210>  1974
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1974

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Phe Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Ala Met Pro Glu 
                245                 250                 


<210>  1975
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1975
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atc agc gaa cag gaa cca gtg gaa ctg att gaa      192
Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttt gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Phe Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1976
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1976

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Phe Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1977
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1977
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atc agc gaa cag gaa cca gtt gaa ctg att gaa      192
Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat gaa tac acg gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Glu Tyr Thr Val Glu Asp         
                85                  90                  95              

tac agg gat atg gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg aca      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag cac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu His Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc gtg gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Val Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttc gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Phe Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1978
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1978

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Glu Tyr Thr Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu His Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Val Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Phe Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1979
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1979
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atc agc gaa cag gaa cca gtt gaa ctg att gaa      192
Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat gaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Glu Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat atg gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg aca      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag cac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu His Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ggt gtg gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Gly Val Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1980
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1980

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Glu Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu His Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Gly Val Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1981
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1981
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atc agc gaa cag gaa cca gtt gaa ctg att gaa      192
Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac acg gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Thr Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg aca      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gct gtg gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Val Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttc gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Phe Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1982
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1982

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Thr Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Val Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Phe Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1983
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1983
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atc agc gaa cag gaa cca gtt gaa ctg att gaa      192
Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gcg atc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Ile Glu Asp         
                85                  90                  95              

tac agg gat atg gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tct caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg aca      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ggt gtg gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Gly Val Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg tta gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1984
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1984

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Ile Glu Asp 
                85                  90                  95      


Tyr Arg Asp Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Gly Val Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1985
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1985
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atc agc gaa cag gaa cca gtt gaa ctg att gaa      192
Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gcg gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg aca      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag cac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu His Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gct tgc gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Cys Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg tta gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1986
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1986

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu His Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Cys Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1987
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1987
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atc agc gaa cag gaa cca gtt gaa ctg att gaa      192
Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gcg gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg aca      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ggc gtg gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Gly Val Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt cgc ttc gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Phe Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1988
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1988

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Gly Val Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Phe Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1989
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1989
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atc agc gaa cag gaa cca gtt gaa ctg att gaa      192
Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg aca      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ggc gtg gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Gly Val Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1990
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1990

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Gly Val Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1991
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1991
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atc agc gaa cag gaa cca gtt gaa ctg att gaa      192
Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg aca      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ggt gtg gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Gly Val Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1992
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1992

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Gly Val Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1993
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1993
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atc agc gaa cag gaa cca gtt gaa ctg att gaa      192
Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat gaa tac gcg gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Glu Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg aca      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ggt gtg gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Gly Val Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttc gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Phe Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta ggg cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Gly Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1994
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1994

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Glu Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Gly Val Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Phe Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Gly Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1995
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1995
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atc agc gaa cag gaa cca gtt gaa ctg att gaa      192
Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat gaa tac gcg gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Glu Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtt gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg aca      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag cac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu His Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ggt gtg gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Gly Val Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag atg ttt tgg ttc gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Met Phe Trp Phe Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1996
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1996

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Glu Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu His Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Gly Val Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Met Phe Trp Phe Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1997
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1997
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atc agc gac cag gaa cca gtg gaa ctg att gaa      192
Pro Gln Leu Ile Pro Ile Ser Asp Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  1998
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1998

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Ile Ser Asp Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  1999
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  1999
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc aaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Lys Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gag tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct ttg tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gcc cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2000
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2000

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Lys Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2001
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2001
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc aaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Lys Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gtt gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Val Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag gag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt acc ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2002
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2002

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Lys Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Val Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2003
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2003
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct aaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Lys Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca cgt aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gtg tat aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Val Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac agt ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2004
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2004

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Lys Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Val Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2005
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2005
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg ata gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac act gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Thr Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag aaa cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2006
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2006

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Thr Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2007
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2007
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg ata gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aga tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Arg Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat gcc gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct cgc caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Arg Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg aat gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Asn Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2008
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2008

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Arg Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Arg Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Asn Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2009
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2009
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg ata gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat att ctg atc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Ile Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gtc ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Val Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2010
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2010

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Ile Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Val Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2011
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2011
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gtg aat gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Val Asn Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt agg tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Arg Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggg acg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Thr Pro Glu                 
                245                 250                                 


<210>  2012
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2012

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Val Asn Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Arg Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Thr Pro Glu 
                245                 250                 


<210>  2013
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2013
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gcg gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc tcc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gcc gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gac cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca cgt aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac agt ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc gtg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Val Pro Glu                 
                245                 250                                 


<210>  2014
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2014

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Val Pro Glu 
                245                 250                 


<210>  2015
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2015
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc acc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Thr Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttt gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Phe Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2016
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2016

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Thr Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Phe Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2017
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2017
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt gga cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

gtc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Val Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gta      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca gat aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Asp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2018
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2018

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Val Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Asp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2019
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2019
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg atc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Ile Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gcc gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttc gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Phe Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2020
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2020

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Ile Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Phe Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2021
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2021
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc aac aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Asn Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aaa cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gcc cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2022
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2022

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Asn Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2023
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2023
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca ata gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2024
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2024

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2025
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2025
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac acg gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Thr Val Glu Asp         
                85                  90                  95              

tac agg gat atg gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg aca      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag cac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu His Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ggc gtg gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Gly Val Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt cgc tta gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2026
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2026

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Thr Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu His Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Gly Val Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2027
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2027
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gcg gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat atg gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tct caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg aca      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag cac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu His Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ggc gtg gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Gly Val Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt cgc ttc gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Phe Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2028
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2028

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu His Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Gly Val Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Phe Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2029
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2029
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gag      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Glu         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg tcg atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Ser Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg aat gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Asn Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta aat tcg ggg gat tcg ccg tac tat tac ccc tct gtg ccg tgg      576
Ala Leu Asn Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Val Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2030
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2030

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Glu 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Ser Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Asn Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asn Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Val Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2031
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2031
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gac atg gtc gaa gct ctg cag atc aag cca ttt gct cta gta      336
Tyr Arg Asp Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat cag gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Gln Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca gat aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Asp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tcc tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt cgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2032
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2032

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Gln Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Asp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2033
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2033
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gac atg gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aaa cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt cgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2034
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2034

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2035
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2035
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat acg gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc atg gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Met Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2036
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2036

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Met Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2037
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2037
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat acg gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag gag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt acc ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2038
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2038

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2039
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2039
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct acg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Thr Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gct gtg gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Val Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2040
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2040

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Thr Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Val Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2041
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2041
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct cgc caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Arg Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta aat tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asn Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2042
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2042

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Arg Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asn Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2043
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2043
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct cgc caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Arg Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2044
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2044

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Arg Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2045
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2045
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg aca      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ggt gtg gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Gly Val Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2046
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2046

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Gly Val Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2047
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2047
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg aat gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Asn Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2048
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2048

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Asn Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2049
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2049
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tca      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2050
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2050

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2051
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2051
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc atg gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Met Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg acc caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2052
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2052

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Met Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2053
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2053
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc atg gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Met Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2054
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2054

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Met Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2055
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2055
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc atg gac tcg ggg gat tcg ccg tac tat tac ccc tct gtg ccg tgg      576
Ala Met Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Val Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc gcg acc ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Ala Thr Pro Glu                 
                245                 250                                 


<210>  2056
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2056

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Met Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Val Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Ala Thr Pro Glu 
                245                 250                 


<210>  2057
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2057
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2058
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2058

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2059
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2059
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcg tgt gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Cys Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2060
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2060

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Cys Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2061
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2061
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gct gtg gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Val Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg acc ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2062
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2062

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Val Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2063
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2063
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ggg atg gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Gly Met Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2064
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2064

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Gly Met Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2065
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2065
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ggg gtg gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Gly Val Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2066
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2066

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Gly Val Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2067
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2067
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ggt gtg gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Gly Val Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2068
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2068

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Gly Val Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2069
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2069
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tcg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2070
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2070

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2071
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2071
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag aaa cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt cgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2072
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2072

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2073
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2073
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aaa cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2074
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2074

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2075
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2075
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2076
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2076

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2077
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2077
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat atg gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg aca      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag cac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu His Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ggc tgc gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Gly Cys Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2078
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2078

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu His Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Gly Cys Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2079
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2079
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat atg gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc atg gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Met Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2080
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2080

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Met Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2081
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2081
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat atg gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag gag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt acc ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2082
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2082

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2083
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2083
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggc atg gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Gly Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt acc ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2084
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2084

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2085
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2085
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggc atg gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Gly Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag gag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2086
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2086

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2087
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2087
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggc atg gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Gly Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aaa cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt cgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2088
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2088

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2089
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2089
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aga tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Arg Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct cgc caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Arg Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg aat gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Asn Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt cgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc gcg acc ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Ala Thr Pro Glu                 
                245                 250                                 


<210>  2090
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2090

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Arg Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Arg Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Asn Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Ala Thr Pro Glu 
                245                 250                 


<210>  2091
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2091
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aga tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Arg Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat gcc gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg aat tcg ccg tac tat tac ccc tct gtg ccg tgg      576
Ala Leu Asp Ser Gly Asn Ser Pro Tyr Tyr Tyr Pro Ser Val Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2092
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2092

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Arg Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asn Ser Pro Tyr Tyr Tyr Pro Ser Val Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2093
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2093
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aga tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Arg Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat gcc gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg tcg atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Ser Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg aat gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Asn Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gtg ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Val Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg acc caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc gcg ccc ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Ala Pro Pro Glu                 
                245                 250                                 


<210>  2094
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2094

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Arg Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Ser Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Asn Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Val Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Ala Pro Pro Glu 
                245                 250                 


<210>  2095
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2095
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat gaa tac gcg gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Glu Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat atg gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg aca      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag cac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu His Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ggt gtg gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Gly Val Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttc gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Phe Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2096
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2096

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Glu Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu His Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Gly Val Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Phe Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2097
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2097
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat gaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Glu Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2098
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2098

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Glu Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2099
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2099
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat gag tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Glu Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat atg gtc gaa gaa ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Met Val Glu Glu Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gtc ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Val Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2100
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2100

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Glu Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Met Val Glu Glu Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Val Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2101
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2101
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat gag tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Glu Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat atg gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2102
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2102

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Glu Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2103
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2103
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat att ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg tcg atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Ser Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg aat gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Asn Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc gcg acc ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Ala Thr Pro Glu                 
                245                 250                                 


<210>  2104
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2104

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Ser Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Asn Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Ala Thr Pro Glu 
                245                 250                 


<210>  2105
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2105
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gcg gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tct caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg aca      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag cac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu His Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ggt gtg gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Gly Val Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttc gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Phe Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2106
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2106

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu His Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Gly Val Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Phe Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2107
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2107
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gcg gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat atg gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg aca      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ggt gtg gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Gly Val Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttc gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Phe Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2108
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2108

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Gly Val Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Phe Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2109
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2109
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gac acg atc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Ile Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aaa cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2110
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2110

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Ile Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2111
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2111
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg aat gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Asn Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2112
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2112

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Asn Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2113
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2113
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttt gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Phe Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2114
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2114

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Phe Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2115
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2115
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gta cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Val Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2116
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2116

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Val Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2117
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2117
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gta      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag aaa cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt cgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2118
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2118

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2119
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2119
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aaa cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt cgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2120
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2120

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2121
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2121
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aaa cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2122
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2122

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2123
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2123
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggc atg gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Gly Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag ctg gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2124
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2124

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2125
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2125
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag ggt      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Gly         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gta      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2126
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2126

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Gly 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2127
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2127
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat gaa tac gcg gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Glu Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg aca      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ggt gtg gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Gly Val Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg tta gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2128
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2128

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Glu Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Gly Val Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2129
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2129
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat gag tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Glu Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat atg gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg aca      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gct atg gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Met Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttc gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Phe Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2130
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2130

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Glu Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Met Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Phe Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2131
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2131
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcg ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cca tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Pro Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg aat gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Asn Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag tcg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Ser Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2132
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2132

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Pro Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Asn Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Ser Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2133
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2133
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctc ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tca gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttc ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cgg gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Arg Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2134
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2134

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Arg Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2135
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2135
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aac gct gtc gct tcg caa atg aag gag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca cgt aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tcc tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac tac ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Tyr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gag ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2136
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2136

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Tyr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2137
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2137
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca aag aag gag att tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Lys Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac gtc tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Val Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac agt ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2138
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2138

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Lys Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Val Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2139
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2139
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat atc ctg gtc tcc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca cgt aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac agt ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gga ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Gly Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2140
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2140

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Gly Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2141
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2141
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cga cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct ttg tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga ctc ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttc ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg tcc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Ser Gly Met Pro Glu                 
                245                 250                                 


<210>  2142
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2142

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Ser Gly Met Pro Glu 
                245                 250                 


<210>  2143
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2143
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac acc gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Thr Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca cgt aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac gtt tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Val Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct tta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2144
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2144

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Thr Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Val Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2145
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2145
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gac gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Asp Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac gtc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Val Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca cgt aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac gtt tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Val Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gcc atc gct ccg gag      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac gac ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Asp Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2146
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2146

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Asp Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Val Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Val Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Asp Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2147
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2147
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gac gtc ggg gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Asp Val Gly Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca cgt aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac gtt tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Val Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac agt ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2148
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2148

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Asp Val Gly Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Val Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2149
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2149
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gcc gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca cgt aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac gtc tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Val Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gtg tat aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Val Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2150
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2150

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Val Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Val Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2151
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2151
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gcc gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca cgt aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2152
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2152

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2153
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2153
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gcc gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca cgt aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac agt ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2154
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2154

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2155
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2155
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gcc gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca cgt aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2156
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2156

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2157
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2157
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gcc gtc ggg gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Gly Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aac gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca cgt aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac gct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac gac ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Asp Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2158
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2158

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Gly Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Asp Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2159
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2159
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gcc gtc ggg gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Gly Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aac gct gtc gct ttg caa atg aag gag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Leu Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca cgt aag gag ctt tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gtg tat aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Val Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac agt ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2160
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2160

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Gly Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Leu Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Val Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2161
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2161
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gcc gtc ggg gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Gly Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca cgt aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag gat aat atc ccg gcg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Glu Asp Asn Ile Pro Ala Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2162
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2162

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Gly Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Asp Asn Ile Pro Ala Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2163
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2163
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gcc gtc ggg gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Gly Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca cgt aag gag att tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac gtt tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Val Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tat aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2164
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2164

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Gly Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Val Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2165
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2165
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttc gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tca gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cgg gct ggg gct agt gca cta gct aat gct ttg tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag tta ggg gaa ttg gtg acg ttc ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gta ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2166
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2166

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2167
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2167
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aac gct gtc gct tcg caa atg aag gag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ctg ttc ggg cca cgt aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Leu Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa tag tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2168
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2168

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Leu Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2169
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2169
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg caa atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly Gln Ile Ile         
        115                 120                 125                     

ttc atc act tca gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct ttg tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag cca tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttc ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggg ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2170
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2170

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly Gln Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2171
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2171
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tca gct gcc ccg ttc gag cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Glu Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct ttg tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tat tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gcc cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttc ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2172
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2172

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Glu Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2173
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2173
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tca gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct ccg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Pro Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tat tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2174
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2174

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Pro Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2175
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2175
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tca gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttc ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2176
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2176

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2177
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2177
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tca gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2178
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2178

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2179
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2179
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tca gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct ctg tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttc ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2180
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2180

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2181
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2181
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tca gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct ttg tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag cca tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg acc gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttc ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggt cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc gtc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2182
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2182

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2183
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2183
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tca gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct ttg tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gcg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Ala Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttc ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt agg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2184
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2184

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Ala Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2185
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2185
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tca gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct ttg tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg acc gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2186
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2186

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2187
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2187
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tca gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct ttg tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gcc cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg aca caa aaa gag ttg ggg gaa ttg gtg acg ttc ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2188
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2188

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2189
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2189
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tca gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct ttg tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttc ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2190
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2190

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2191
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2191
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tca gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct ttg tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tat ccc tct gag cca tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttc ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2192
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2192

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2193
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2193
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tca gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct ttg tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tgc ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Cys Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gcc cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttc ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2194
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2194

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Cys Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2195
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2195
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tca gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct ttg tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tat tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2196
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2196

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2197
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2197
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tca gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct ttg tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg agt      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Ser         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gcc cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttc ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2198
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2198

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Ser 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2199
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2199
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tca gct gcc ccg ttc ggg cca tgg aag ggg cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Gly Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct ttg tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gcc cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttc ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2200
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2200

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Gly Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2201
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2201
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tca gct gct ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct ttg tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttc ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2202
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2202

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2203
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2203
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttc ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2204
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2204

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2205
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2205
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tat tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttc ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2206
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2206

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2207
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2207
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct ttg tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gcc cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttc ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2208
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2208

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2209
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2209
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct ttg tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tat tat tat ccc tct gag cca tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttc ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2210
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2210

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2211
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2211
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc tgg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Trp Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct agt gca cta gct aat gct ttg tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gcc cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttc ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2212
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2212

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Trp Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2213
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2213
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cat atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tca gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcc      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aaa gaa cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gaa ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

cca cga cta agg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Pro Arg Leu Arg Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc caa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Gln                 
                245                 250                                 


<210>  2214
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2214

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Pro Arg Leu Arg Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Gln 
                245                 250                 


<210>  2215
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2215
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cat atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tca gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct ttg tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttc ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt ggt tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Gly Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2216
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2216

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Gly Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2217
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2217
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg cga atg aag aag cga aag tcg ggg cac atc gtc      384
Asn Ala Val Ala Ser Arg Met Lys Lys Arg Lys Ser Gly His Ile Val         
        115                 120                 125                     

ttc atc act tca gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct ttg tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tat ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttc ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2218
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2218

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Arg Met Lys Lys Arg Lys Ser Gly His Ile Val 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2219
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2219
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca att gat aaa tac gcc gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca cgt aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag gac aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Glu Asp Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2220
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2220

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Asp Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2221
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2221
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg tca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Ser Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tca gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct ttg tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttc ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2222
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2222

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Ser Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2223
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2223
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc tgc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Cys Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gac gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Asp Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca cgt aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tat aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2224
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2224

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Cys Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Asp Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2225
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2225
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc tgc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Cys Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gac gtc ggg gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Asp Val Gly Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca cgt aag gag ctt tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gtg tat aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Val Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2226
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2226

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Cys Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Asp Val Gly Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Val Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2227
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2227
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gct gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Ala Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tcc tcg gct cga gct ggg gct agt gca cta gct aat gct ttg tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttc ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2228
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2228

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Ala Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2229
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2229
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cgt gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly Arg Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gcc gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aac gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca cgt aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac gtc tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Val Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2230
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2230

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly Arg Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Val Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2231
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2231
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cgt gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly Arg Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca cgt aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac gtt tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Val Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac agt ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2232
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2232

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly Arg Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Val Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2233
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2233
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cgt gtc gat gtc ctg gtc tgc aac gat      240
Ala Val Thr Ser Ala Leu Gly Arg Val Asp Val Leu Val Cys Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gac gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Asp Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ctg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc gtc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2234
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2234

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly Arg Val Asp Val Leu Val Cys Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Asp Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2235
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2235
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cgt gtc gat gtc ctg gtc tgc aac gat      240
Ala Val Thr Ser Ala Leu Gly Arg Val Asp Val Leu Val Cys Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gcc gtc ggg gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Gly Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca cgt aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2236
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2236

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly Arg Val Asp Val Leu Val Cys Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Gly Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2237
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2237
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cgt gtc gat gtc ctg gtc tgc aac gat      240
Ala Val Thr Ser Ala Leu Gly Arg Val Asp Val Leu Val Cys Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg tgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Trp Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca cgt aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac gtt tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Val Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gtg tat aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Val Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2238
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2238

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly Arg Val Asp Val Leu Val Cys Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Trp Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Val Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Val Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2239
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2239
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ttt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Phe Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tca gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gcg cta gct aat gct ttg tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag cca tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttc ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2240
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2240

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Phe Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2241
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2241
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc act agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt acc ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggg atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2242
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2242

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2243
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2243
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gtt gtc aat agc gcc ctt ggt caa gtc gat atc ctg gtc agc aac gat      240
Val Val Asn Ser Ala Leu Gly Gln Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggc atg gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Gly Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag gag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt acc ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2244
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2244

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Val Val Asn Ser Ala Leu Gly Gln Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2245
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2245
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gtt gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gac      240
Val Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt acc ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2246
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2246

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Val Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2247
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2247
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gtt gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Val Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat acg gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag gag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt acc ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2248
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2248

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Val Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2249
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2249
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gtt gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Val Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt acc ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2250
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2250

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Val Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2251
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2251
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gtt gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Val Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag gag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt acc ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2252
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2252

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Val Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2253
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2253
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gtt gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Val Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat atg gtc gaa act ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Met Val Glu Thr Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag gag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt acc ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2254
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2254

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Val Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Met Val Glu Thr Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2255
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2255
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gtt gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Val Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat atg gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgc cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt acc ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2256
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2256

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Val Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2257
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2257
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gtt gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Val Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat atg gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt acc ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2258
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2258

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Val Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2259
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2259
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gtt gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Val Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat atg gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag gag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt acc ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2260
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2260

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Val Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2261
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2261
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gtt gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Val Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat atg gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag gag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt acc ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2262
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2262

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Val Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2263
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2263
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gtt gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Val Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggc atg gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Gly Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt acc ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2264
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2264

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Val Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2265
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2265
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gtt gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Val Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggc atg gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Gly Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag gag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt acc ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2266
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2266

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Val Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2267
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2267
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gtt gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Val Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

gtc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Val Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag gag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt acc ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2268
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2268

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Val Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Val Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2269
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2269
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctt att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gaa cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2270
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2270

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2271
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2271
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gta gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gag      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Glu         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct cgc caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Arg Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc atg gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Met Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2272
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2272

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Glu 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Arg Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Met Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2273
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2273
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gta gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gag      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Glu         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct cgc caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Arg Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc gcg acc ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Ala Thr Pro Glu                 
                245                 250                                 


<210>  2274
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2274

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Glu 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Arg Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Ala Thr Pro Glu 
                245                 250                 


<210>  2275
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2275
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gta gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gag      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Glu         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg aat gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Asn Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta aat tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asn Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgc tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2276
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2276

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Glu 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Asn Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asn Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2277
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2277
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gta gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gag      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Glu         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc atg gac tcg ggg gat tcg ccg tac tat tac ccc tct gtg ccg tgg      576
Ala Met Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Val Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2278
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2278

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Glu 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Met Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Val Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2279
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2279
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gta gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gag      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Glu         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg cag atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc atg gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Met Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2280
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2280

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Glu 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Met Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2281
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2281
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gta gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct cgc caa atg aag ctt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Arg Gln Met Lys Leu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg aat gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Asn Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta aat tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asn Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2282
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2282

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Arg Gln Met Lys Leu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Asn Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asn Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2283
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2283
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gta gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg aat gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Asn Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2284
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2284

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Asn Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2285
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2285
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gta gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg aat gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Asn Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gtg ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Val Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2286
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2286

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Asn Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Val Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2287
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2287
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gta gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc atg gac tcg ggg gat tcg ccg tac tat tac ccc tct gtg ccg tgg      576
Ala Met Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Val Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2288
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2288

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Met Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Val Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2289
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2289
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gta gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2290
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2290

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2291
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2291
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gta gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg tcg atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Ser Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg aat gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Asn Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc atg gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Met Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2292
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2292

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Ser Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Asn Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Met Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2293
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2293
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gta gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg tcg atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Ser Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc atg gac tcg ggg aat tcg ccg tac tat tac ccc tct gtg ccg tgg      576
Ala Met Asp Ser Gly Asn Ser Pro Tyr Tyr Tyr Pro Ser Val Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2294
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2294

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Ser Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Met Asp Ser Gly Asn Ser Pro Tyr Tyr Tyr Pro Ser Val Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2295
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2295
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gta gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aga tac gct gtc gag gag      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Arg Tyr Ala Val Glu Glu         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct cgc caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Arg Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg aat gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Asn Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta aat tcg ggg gat tcg ccg tac tat tac ccc tct gtg ccg tgg      576
Ala Leu Asn Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Val Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2296
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2296

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Arg Tyr Ala Val Glu Glu 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Arg Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Asn Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asn Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Val Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2297
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2297
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gta gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aga tac gct gtc gag gag      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Arg Tyr Ala Val Glu Glu         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct cgc caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Arg Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg aat gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Asn Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gtg ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Val Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2298
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2298

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Arg Tyr Ala Val Glu Glu 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Arg Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Asn Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Val Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2299
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2299
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gta gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aga tac gct gtc gag gag      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Arg Tyr Ala Val Glu Glu         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc atg gac tcg ggg gat tcg ccg tac tat tac ccc tct gtg ccg tgg      576
Ala Met Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Val Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2300
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2300

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Arg Tyr Ala Val Glu Glu 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Met Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Val Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2301
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2301
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gta gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aga tac gct gtc gag gag      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Arg Tyr Ala Val Glu Glu         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tcg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg aat gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Asn Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc atg gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Met Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2302
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2302

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Arg Tyr Ala Val Glu Glu 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Asn Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Met Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2303
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2303
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gta gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aga tac gct gtc gag gag      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Arg Tyr Ala Val Glu Glu         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg tcg atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Ser Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg acc      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg ggt tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Gly Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2304
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2304

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Arg Tyr Ala Val Glu Glu 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Ser Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Gly Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2305
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2305
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gta gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aga tac gct gtc gag gag      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Arg Tyr Ala Val Glu Glu         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg tcg atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Ser Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg aat gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Asn Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta aat tcg ggg gat tcg ccg tac tat tac ccc tct gtg ccg tgg      576
Ala Leu Asn Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Val Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2306
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2306

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Arg Tyr Ala Val Glu Glu 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Ser Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Asn Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asn Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Val Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2307
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2307
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gta gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aga tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Arg Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct cgc caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Arg Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg aat gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Asn Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc atg gac tcg ggg gat tcg ccg tac tat tac ccc tct gtg ccg tgg      576
Ala Met Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Val Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gcg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Ala Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2308
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2308

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Arg Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Arg Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Asn Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Met Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Val Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Ala Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2309
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2309
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gta gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aga tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Arg Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg tcg atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Ser Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2310
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2310

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Arg Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Ser Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2311
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2311
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gta gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aga tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Arg Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat gcc gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct cgc caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Arg Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg aat gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Asn Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta aat tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asn Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc gcc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Ala Met Pro Glu                 
                245                 250                                 


<210>  2312
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2312

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Arg Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Arg Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Asn Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asn Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Ala Met Pro Glu 
                245                 250                 


<210>  2313
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2313
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gta gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aga tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Arg Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat gcc gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg aat gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Asn Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta aat tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asn Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc gcg acc ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Ala Thr Pro Glu                 
                245                 250                                 


<210>  2314
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2314

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Arg Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Asn Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asn Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Ala Thr Pro Glu 
                245                 250                 


<210>  2315
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2315
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gta gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aga tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Arg Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat gcc gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg aat gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Asn Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gtg ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Val Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2316
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2316

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Arg Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Asn Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Val Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2317
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2317
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gta gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aga tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Arg Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat gcc gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc atg gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Met Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act cag aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2318
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2318

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Arg Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Met Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2319
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2319
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gta gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aga tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Arg Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat gcc gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta aat tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asn Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2320
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2320

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Arg Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asn Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2321
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2321
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gta gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aga tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Arg Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat gcc gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg tcg atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Ser Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gcc cga gct ggg gcg agt gca ctg gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg aat tcg ccg tac tat tac ccc tct gtg ccg tgg      576
Ala Leu Asp Ser Gly Asn Ser Pro Tyr Tyr Tyr Pro Ser Val Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg acc caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2322
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2322

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Arg Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Ser Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asn Ser Pro Tyr Tyr Tyr Pro Ser Val Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2323
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2323
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gta gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aga tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Arg Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat gcc gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg tcg atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Ser Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg aat gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Asn Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc atg gac tcg ggg gat tcg ccg tac tat tac ccc tct gtg ccg tgg      576
Ala Met Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Val Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2324
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2324

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Arg Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Ser Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Asn Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Met Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Val Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2325
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2325
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gta gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aga tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Arg Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat gcc gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg tcg atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Ser Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2326
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2326

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Arg Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Ser Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2327
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2327
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gtg gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg aat gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Asn Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttt gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Phe Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2328
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2328

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Asn Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Phe Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2329
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2329
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gtg gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gcg tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg aca ctt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Leu Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2330
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2330

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Leu Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2331
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2331
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gtg gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg ccg atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2332
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2332

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2333
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2333
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gtg gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg aat gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Asn Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2334
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2334

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Asn Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2335
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2335
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gtg gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg aat gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Asn Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttt gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Phe Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2336
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2336

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Asn Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Phe Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2337
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2337
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gtg gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg aat gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Asn Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttt gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Phe Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggg acg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Thr Pro Glu                 
                245                 250                                 


<210>  2338
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2338

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Asn Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Phe Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Thr Pro Glu 
                245                 250                 


<210>  2339
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2339
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gtg gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg aat gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Asn Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttt gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Phe Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggg atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2340
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2340

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Asn Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Phe Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2341
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2341
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gtg gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg aat gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Asn Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa ggg ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Gly Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc caa gtg ttt tgg ttt gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Phe Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2342
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2342

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Asn Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Gly Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Phe Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2343
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2343
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gtg gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttt gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Phe Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2344
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2344

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Phe Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2345
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2345
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gtt gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg aca      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag cac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu His Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ggt tgc gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Gly Cys Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt cgc tta gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2346
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2346

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu His Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Gly Cys Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2347
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2347
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gtt gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg aca      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ggt gtg gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Gly Val Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttc gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Phe Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2348
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2348

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Gly Val Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Phe Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2349
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2349
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gtt gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga atg tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Met Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg aca      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag cac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu His Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ggt gtg gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Gly Val Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg tta gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2350
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2350

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Met Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu His Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Gly Val Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2351
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2351
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gtt gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tct caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg aca      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag cac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu His Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ggt gtg gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Gly Val Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2352
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2352

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu His Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Gly Val Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2353
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2353
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gtt gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg aca      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag cac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu His Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ggc gtg gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Gly Val Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg tta gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2354
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2354

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu His Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Gly Val Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2355
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2355
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gtt gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg aca      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag cac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu His Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ggc tgc gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Gly Cys Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg tta gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2356
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2356

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu His Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Gly Cys Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2357
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2357
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gtt gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tct caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg aca      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag cac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu His Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ggc tgc gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Gly Cys Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg tta gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2358
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2358

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu His Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Gly Cys Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2359
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2359
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gtt gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat atg gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tct caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg aca      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag cac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu His Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ggt gtg gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Gly Val Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg tta gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2360
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2360

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu His Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Gly Val Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2361
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2361
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gtt gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat gaa tac gcg gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Glu Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat atg gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg aca      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag cac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu His Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gct tgc gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Cys Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttc gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Phe Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2362
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2362

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Glu Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu His Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Cys Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Phe Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2363
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2363
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gtt gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gag tgg cgg cca atc gat gaa tac gcg gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Glu Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg aca      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ggt gtg gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Gly Val Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2364
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2364

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Glu Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Gly Val Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2365
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2365
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gtt gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

gtc gcg cct gtg gaa tgg cgg cca atc gat gaa tac gcg gtc gag gat      288
Val Ala Pro Val Glu Trp Arg Pro Ile Asp Glu Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat atg gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tct caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg aca      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gct atg gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Met Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt cgc tta gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2366
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2366

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Val Ala Pro Val Glu Trp Arg Pro Ile Asp Glu Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Met Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2367
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2367
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg ggc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Gly Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cgt gtc gat atc ctg gtc tcc aac gat      240
Ala Val Thr Ser Ala Leu Gly Arg Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gcc gtc ggg gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Gly Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca cgt aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2368
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2368

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Gly Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly Arg Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Gly Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2369
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2369
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata ccg atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttt gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Phe Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2370
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2370

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Phe Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2371
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2371
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ttg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cgc atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly Arg Ile Ile         
        115                 120                 125                     

ttc atc act tca gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct ttg tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tat ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ctg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2372
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2372

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly Arg Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2373
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2373
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gag acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg ata gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat gag tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Glu Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat atg gtc gaa gca ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aac gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag cac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu His Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2374
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2374

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Glu Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu His Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2375
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2375
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gtt gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Val Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg aca cca atg agc gaa cag gaa cca gct gaa ctg ata gaa      192
Pro Gln Leu Thr Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gca ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gtc ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Val Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2376
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2376

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Val Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Thr Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Val Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2377
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2377
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gtt gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Val Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg ata gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg atc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Ile Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat gag tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Glu Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat atg gtc gaa gca ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gtc ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Val Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2378
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2378

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Val Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Ile Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Glu Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Val Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2379
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2379
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gtt gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Val Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg ata gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat gag tac act gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Glu Tyr Thr Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gtc ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Val Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2380
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2380

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Val Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Glu Tyr Thr Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Val Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2381
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2381
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gtt gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Val Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg ata gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat gag tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Glu Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat atg gtc gaa gaa ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Met Val Glu Glu Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gtc ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Val Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgc gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2382
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2382

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Val Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Glu Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Met Val Glu Glu Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Val Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2383
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2383
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gtt gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Val Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg ata gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat att ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac act gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Thr Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2384
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2384

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Val Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Thr Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2385
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2385
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gtt gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Val Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg ata gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat att ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat atg gtc gaa gaa ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Met Val Glu Glu Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2386
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2386

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Val Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Met Val Glu Glu Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2387
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2387
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gtt gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Val Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2388
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2388

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Val Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2389
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2389
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gtt gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Val Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat gag tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Glu Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat acg gtc gaa gaa ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Glu Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gtc ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Val Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2390
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2390

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Val Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Glu Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Glu Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Val Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2391
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2391
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gtt gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Val Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat gag tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Glu Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat atg gtc gaa gca ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2392
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2392

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Val Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Glu Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2393
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2393
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gtt gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Val Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat gag tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Glu Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat atg gtc gaa gca ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gtc ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Val Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2394
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2394

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Val Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Glu Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Val Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2395
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2395
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gga gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Gly Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gcc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Ala Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tca gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct ttg tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tat ccc tct gag cca tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttc ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2396
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2396

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Gly Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Ala Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2397
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2397
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct caa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Gln Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gta gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gca ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct agc caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gac tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc gca atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Ala Met Pro Glu                 
                245                 250                                 


<210>  2398
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2398

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Gln Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Ala Met Pro Glu 
                245                 250                 


<210>  2399
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2399
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atc agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc act agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gac acg gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt acc ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc gag gtg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Glu Val Pro Glu                 
                245                 250                                 


<210>  2400
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2400

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Glu Val Pro Glu 
                245                 250                 


<210>  2401
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2401
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc aac aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Asn Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gac atg gtc gaa gct ctg cag atc aag cca ttt gct cta gta      336
Tyr Arg Asp Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat cag gtc gct tcg caa atg aag aaa cga aag tcg ggg cac atc atc      384
Asn Gln Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2402
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2402

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Asn Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Gln Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2403
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2403
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gac atg atc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Met Ile Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat cag gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Gln Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2404
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2404

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Met Ile Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Gln Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2405
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2405
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag ctg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Leu Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc gat atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Asp Met Pro Glu                 
                245                 250                                 


<210>  2406
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2406

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Leu Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Asp Met Pro Glu 
                245                 250                 


<210>  2407
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2407
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag ctg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Leu Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2408
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2408

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Leu Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2409
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2409
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2410
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2410

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2411
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2411
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc gac atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Asp Met Pro Glu                 
                245                 250                                 


<210>  2412
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2412

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Asp Met Pro Glu 
                245                 250                 


<210>  2413
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2413
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc gat atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Asp Met Pro Glu                 
                245                 250                                 


<210>  2414
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2414

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Asp Met Pro Glu 
                245                 250                 


<210>  2415
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2415
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2416
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2416

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2417
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2417
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggc acg gtc gaa gct ctg cag atc aag cca ttt gct cta gta      336
Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag aaa cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt cgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2418
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2418

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2419
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2419
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggc atg atc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Gly Met Ile Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2420
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2420

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Met Ile Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2421
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2421
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agt aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2422
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2422

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2423
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2423
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc aac aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Asn Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggc atg gtc gaa gct ctg cag atc aag cca ttt gct cta gta      336
Tyr Arg Gly Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag aaa cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt cgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2424
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2424

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Asn Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2425
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2425
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gac acg gtc gaa gct ctg cag atc aag cca ttt gct cta gta      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag aaa cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt cgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2426
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2426

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2427
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2427
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gac atg atc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Met Ile Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga ctg ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2428
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2428

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Met Ile Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2429
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2429
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat att ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggc atg gtc gaa gct ctg cag atc aag cca ttt gct cta gta      336
Tyr Arg Gly Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aaa cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt cgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2430
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2430

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2431
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2431
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gag agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca cgt agg gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Arg Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag gat aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Glu Asp Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac agt ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ctg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2432
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2432

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Arg Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Asp Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2433
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2433
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gag agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca ttg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Leu Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gcg      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2434
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2434

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Leu Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2435
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2435
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gag agc ttt aag cat cag gat gaa cta gaa gct ttt gtt gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Val Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg ata gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat acg gtc gaa gaa ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Glu Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2436
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2436

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Val Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Glu Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2437
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2437
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat gca gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Ala Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag ctg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Leu Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc gat atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Asp Met Pro Glu                 
                245                 250                                 


<210>  2438
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2438

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Ala Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Leu Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Asp Met Pro Glu 
                245                 250                 


<210>  2439
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2439
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat gca gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Ala Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2440
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2440

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Ala Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2441
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2441
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gag gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cac cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tca gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct ttg tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gcc cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2442
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2442

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2443
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2443
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg ggc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Gly Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg atc gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tca gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct ttg tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttc ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2444
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2444

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Gly Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2445
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2445
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ccg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Pro Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc ggc gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Gly Asp         
                85                  90                  95              

tac agg gat gcc gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac act ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt act ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2446
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2446

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Pro Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Gly Asp 
                85                  90                  95      


Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2447
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2447
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa aac ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Asn Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg att cca atg agc gaa cag gaa cca gtt gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg caa cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag cgc cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc agc ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt act ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttc ccc gtt gta gag cgt tgg ccc gaa gtg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Glu Val Pro Glu                 
                245                 250                                 


<210>  2448
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2448

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Asn Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Glu Val Pro Glu 
                245                 250                 


<210>  2449
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2449
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat caa ctg aaa gct ttt gct aaa acc tac      144
Glu Ser Phe Lys His Gln Asp Gln Leu Lys Ala Phe Ala Lys Thr Tyr         
        35                  40                  45                      

cca cag ctg atc cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cag gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly Gln Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc tat cct gtg gaa tgg cag cca atc gat aaa tac gct gtc gag gat      288
Ile Tyr Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gac cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tat cta cac tcg ggg gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ctg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg aca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Thr         
225                 230                 235                 240         

ggc ggc ttt ccc gca ata gac cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Ala Ile Asp Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2450
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2450

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Gln Leu Lys Ala Phe Ala Lys Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly Gln Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Tyr Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Thr 
225                 230                 235                 240 


Gly Gly Phe Pro Ala Ile Asp Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2451
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2451
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat caa ctg aaa gct ttt gct aaa acc tac      144
Glu Ser Phe Lys His Gln Asp Gln Leu Lys Ala Phe Ala Lys Thr Tyr         
        35                  40                  45                      

cca cag ctg atc cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cag gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly Gln Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc tat cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Tyr Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gaa cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac ctg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Leu Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ctg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg aca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Thr         
225                 230                 235                 240         

ggc ggc ttt ccc gca ata gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2452
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2452

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Gln Leu Lys Ala Phe Ala Lys Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly Gln Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Tyr Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Leu Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Thr 
225                 230                 235                 240 


Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2453
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2453
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat caa ctg aaa gct ttt gct aaa acc tac      144
Glu Ser Phe Lys His Gln Asp Gln Leu Lys Ala Phe Ala Lys Thr Tyr         
        35                  40                  45                      

cca cag ctg atc cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cag gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly Gln Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc tat cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Tyr Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gaa cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gta cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Val Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tat cta cac tcg ggg gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ctg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg aca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Thr         
225                 230                 235                 240         

ggc ggc ttt ccc gca ata gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2454
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2454

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Gln Leu Lys Ala Phe Ala Lys Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly Gln Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Tyr Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Val Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Thr 
225                 230                 235                 240 


Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2455
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2455
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg act cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Thr Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat gcc gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag cgc cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc agc ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt act ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2456
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2456

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Thr Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2457
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2457
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg act cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Thr Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc ggc gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Gly Asp         
                85                  90                  95              

tac agg gat gcc gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gaa cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggt cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt act ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2458
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2458

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Thr Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Gly Asp 
                85                  90                  95      


Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2459
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2459
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg act cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Thr Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc ggc gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Gly Asp         
                85                  90                  95              

tac agg gat gcc gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gaa cga aag tcg ggg cat atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac ctg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Leu Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt act ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc agc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Ser Met Pro Glu                 
                245                 250                                 


<210>  2460
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2460

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Thr Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Gly Asp 
                85                  90                  95      


Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Leu Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Ser Met Pro Glu 
                245                 250                 


<210>  2461
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2461
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg act cca atg agc gaa cag gaa cca gtt gaa ctg att gaa      192
Pro Gln Leu Thr Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg caa cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag cgc cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg agt      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Ser         
    130                 135                 140                         

tac gct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt act ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc gtg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Val Pro Glu                 
                245                 250                                 


<210>  2462
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2462

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Thr Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Ser 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Val Pro Glu 
                245                 250                 


<210>  2463
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2463
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg act cca atg agc gaa cag gaa cca gtt gaa ctg att gaa      192
Pro Gln Leu Thr Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg caa cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gcc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac act ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt act ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2464
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2464

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Thr Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2465
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2465
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg act cca atg agc gaa cag gaa cca gtt gaa ctg att gaa      192
Pro Gln Leu Thr Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg caa cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat gcc gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gaa cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc agc ttc ggg cca tgg aag gag cta tcg agt      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Ser         
    130                 135                 140                         

tac gct tcg gct cga gct ggg gcc agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt act ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2466
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2466

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Thr Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Ser 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2467
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2467
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg act cca atg agc gaa cag gaa cca gtt gaa ctg att gaa      192
Pro Gln Leu Thr Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gaa cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aac atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt act ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gcg gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Ala Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2468
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2468

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Thr Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ala Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2469
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2469
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg act cca atg agc gaa cag gaa cca gtt gaa ctg att gaa      192
Pro Gln Leu Thr Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gaa cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac ctg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Leu Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt act ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2470
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2470

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Thr Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Leu Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2471
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2471
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg act cca atg agc gaa cag gaa cca gtt gaa ctg att gaa      192
Pro Gln Leu Thr Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac act ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt act ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc gtg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Val Pro Glu                 
                245                 250                                 


<210>  2472
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2472

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Thr Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Val Pro Glu 
                245                 250                 


<210>  2473
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2473
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg act cca atg agc gaa cag gaa cca gtt gaa ctg att gaa      192
Pro Gln Leu Thr Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg agt      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Ser         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac act ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt act ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2474
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2474

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Thr Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Ser 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2475
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2475
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg act cca atg agc gaa cag gaa cca gtt gaa ctg att gaa      192
Pro Gln Leu Thr Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat gcc gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag cgc cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc agc ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac act ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt act ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc gaa gtg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Glu Val Pro Glu                 
                245                 250                                 


<210>  2476
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2476

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Thr Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Glu Val Pro Glu 
                245                 250                 


<210>  2477
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2477
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg act cca atg agc gaa cag gaa cca gtt gaa ctg att gaa      192
Pro Gln Leu Thr Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat gcc gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag cgc cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac act ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt act ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2478
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2478

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Thr Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2479
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2479
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg act cca atg agc gaa cag gaa cca gtt gaa ctg att gaa      192
Pro Gln Leu Thr Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat gcc gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gaa cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac act ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt act ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc gaa gtg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Glu Val Pro Glu                 
                245                 250                                 


<210>  2480
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2480

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Thr Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Glu Val Pro Glu 
                245                 250                 


<210>  2481
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2481
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg act cca atg agc gaa cag gaa cca gtt gaa ctg att gaa      192
Pro Gln Leu Thr Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc ggc gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Gly Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gaa cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc agc ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac ctg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Leu Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt act ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc agc atg tcc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Ser Met Ser Glu                 
                245                 250                                 


<210>  2482
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2482

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Thr Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Gly Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Leu Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Ser Met Ser Glu 
                245                 250                 


<210>  2483
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2483
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg act cca atg agc gaa cag gaa cca gtt gaa ctg att gaa      192
Pro Gln Leu Thr Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc ggc gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Gly Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc agc ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aac atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac ctg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Leu Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt act ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2484
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2484

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Thr Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Gly Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Leu Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2485
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2485
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg act cca atg agc gaa cag gaa cca gtt gaa ctg att gaa      192
Pro Gln Leu Thr Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc act agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat gcc gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gaa cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gcc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt act ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2486
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2486

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Thr Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2487
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2487
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg act cca att agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Thr Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg caa cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gaa cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac act ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt act ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2488
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2488

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Thr Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2489
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2489
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg act cca att agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Thr Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat gcc gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag cgc cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac ctg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Leu Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt act ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2490
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2490

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Thr Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Leu Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2491
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2491
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg act cca att agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Thr Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc ggc gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Gly Asp         
                85                  90                  95              

tac agg gat gcc gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag cgc cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gcc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt act ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2492
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2492

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Thr Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Gly Asp 
                85                  90                  95      


Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2493
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2493
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg act cca att agc gaa cag gaa cca gtt gaa ctg att gaa      192
Pro Gln Leu Thr Pro Ile Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg caa cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag cgc cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg agt      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Ser         
    130                 135                 140                         

tac gct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt act ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc gaa gtg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Glu Val Pro Glu                 
                245                 250                                 


<210>  2494
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2494

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Thr Pro Ile Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Ser 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Glu Val Pro Glu 
                245                 250                 


<210>  2495
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2495
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg act cca att agc gaa cag gaa cca gtt gaa ctg att gaa      192
Pro Gln Leu Thr Pro Ile Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg caa cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat gcc gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag cgc cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc agc ttc ggg cca tgg aag gag cta tcg agt      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Ser         
    130                 135                 140                         

tac gct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gcg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt act ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2496
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2496

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Thr Pro Ile Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Ser 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2497
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2497
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg act cca att agc gaa cag gaa cca gtt gaa ctg att gaa      192
Pro Gln Leu Thr Pro Ile Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg caa cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat gcc gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag cgc cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gcc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac act ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt act ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2498
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2498

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Thr Pro Ile Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2499
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2499
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg act cca att agc gaa cag gaa cca gtt gaa ctg att gaa      192
Pro Gln Leu Thr Pro Ile Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gac act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gaa cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac act ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gag ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt act ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc agc gtg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Ser Val Pro Glu                 
                245                 250                                 


<210>  2500
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2500

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Thr Pro Ile Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Ser Val Pro Glu 
                245                 250                 


<210>  2501
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2501
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg act cca att agc gaa cag gaa cca gtt gaa ctg att gaa      192
Pro Gln Leu Thr Pro Ile Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag cgc cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac act ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt act ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2502
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2502

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Thr Pro Ile Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2503
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2503
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg act cca att agc gaa cag gaa cca gtt gaa ctg att gaa      192
Pro Gln Leu Thr Pro Ile Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat gcc gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc agc ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gcc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac act ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2504
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2504

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Thr Pro Ile Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2505
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2505
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gcc gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2506
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2506

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2507
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2507
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc aac aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Asn Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aaa cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2508
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2508

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Asn Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2509
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2509
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cag cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggc acg atc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Gly Thr Ile Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca gat aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Asp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt cgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2510
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2510

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Thr Ile Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Asp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2511
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2511
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gcg gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gac atg gtc gaa gct ctg cag atc aag cca ttt gct cta gta      336
Tyr Arg Asp Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat cag gtc gct tcg caa atg aag aaa cga aag tcg ggg cac atc atc      384
Asn Gln Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac tcg tgg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Trp Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2512
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2512

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Gln Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Ser Trp Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2513
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2513
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gac atg gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2514
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2514

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2515
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2515
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gta      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat cag gtc gct tcg caa atg aag aaa cga aag tcg ggg cac atc atc      384
Asn Gln Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt cgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2516
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2516

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Gln Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2517
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2517
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt cgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2518
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2518

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2519
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2519
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc aac aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Asn Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gac atg gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt cgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2520
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2520

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Asn Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2521
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2521
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc aac aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Asn Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac tcg tgg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Trp Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt cgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2522
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2522

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Asn Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Ser Trp Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2523
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2523
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg caa cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag cgc cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc agc ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac act ggg gat tcg cct tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt act ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2524
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2524

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2525
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2525
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg caa cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag cgc cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac act ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2526
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2526

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2527
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2527
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg caa cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gaa cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc agc ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac tcg gga gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt act ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2528
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2528

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2529
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2529
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg caa cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gag gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc agc ttc ggg cca tgg aag gag cta tcg agt      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Ser         
    130                 135                 140                         

tac gct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac act ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt act ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2530
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2530

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Ser 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2531
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2531
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg caa cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat gcc gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gaa cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc agc ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt act ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2532
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2532

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2533
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2533
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gac acg atc gaa gct ctg cag atc aag cca ttt gct cta gta      336
Tyr Arg Asp Thr Ile Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gag act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Glu Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2534
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2534

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Ile Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Glu Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2535
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2535
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gac acg gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag aaa cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2536
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2536

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2537
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2537
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gac acg gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aaa cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt cgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2538
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2538

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2539
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2539
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gac atg atc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Met Ile Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aaa cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tat cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tcc tgt gat tat ttg act ggc cag gtg ttt cgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2540
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2540

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Met Ile Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2541
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2541
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gta      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag aaa cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2542
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2542

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2543
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2543
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gta      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca gat aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Asp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg cgt      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Arg         
                165                 170                 175             

ttt cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt cgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2544
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2544

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Asp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Arg 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2545
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2545
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aaa cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt cgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2546
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2546

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2547
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2547
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aaa cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tat cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt cgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Leu Ala         
225                 230                 235                 240         

ggc ggc ttt cca gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2548
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2548

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2549
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2549
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aaa cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt cgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2550
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2550

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2551
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2551
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gaa cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac act ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt act ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2552
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2552

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2553
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2553
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gaa cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aac gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac act ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc gaa gtg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Glu Val Pro Glu                 
                245                 250                                 


<210>  2554
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2554

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Glu Val Pro Glu 
                245                 250                 


<210>  2555
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2555
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat gcc gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag cgc cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt aat ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Asn Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc gaa gtg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Glu Val Pro Glu                 
                245                 250                                 


<210>  2556
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2556

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Asn Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Glu Val Pro Glu 
                245                 250                 


<210>  2557
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2557
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat gcc gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gaa cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac act ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac ctg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Leu Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2558
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2558

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Leu Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2559
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2559
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat gcc gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc agc ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac act ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt act ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2560
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2560

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2561
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2561
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggc acg gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aaa cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca gat aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Asp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg agt      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Ser         
                165                 170                 175             

ttt cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2562
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2562

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Asp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Ser 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2563
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2563
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc ggc gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Gly Asp         
                85                  90                  95              

tac agg gat gcc gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc agc ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gct tcg gct cga gct ggg gcc agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac act ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt act ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc gaa gtg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Glu Val Pro Glu                 
                245                 250                                 


<210>  2564
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2564

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Gly Asp 
                85                  90                  95      


Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Glu Val Pro Glu 
                245                 250                 


<210>  2565
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2565
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca gac aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Asp Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2566
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2566

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Asp Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2567
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2567
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt act gtc gaa gct ctg cag atc aag cca ttt gct cta gcg      336
Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2568
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2568

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2569
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2569
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca gac aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Asp Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg cgg      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Arg         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2570
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2570

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Asp Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Arg 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2571
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2571
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gac gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2572
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2572

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2573
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2573
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gac act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac ctg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Leu Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ctg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2574
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2574

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Leu Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2575
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2575
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gac act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tat cta cac tcg ggg gat tcg aag tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Lys Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac ctg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Leu Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt ata gac cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Asp Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2576
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2576

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Lys Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Leu Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Asp Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2577
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2577
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gac act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gtt tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Val Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac ctg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Leu Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2578
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2578

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Val Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Leu Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2579
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2579
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gac act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gtt tcg caa atg aag gag cga aag tcg ggg cac atc atc      384
Asn Ala Val Val Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tat cta cac tcg ggg gat tcg aag tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Lys Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gct ata gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2580
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2580

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Val Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Lys Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2581
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2581
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggc act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca gac aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Asp Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg cgg      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Arg         
                165                 170                 175             

ttc cta gat tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act cag aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2582
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2582

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Asp Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Arg 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2583
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2583
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cag cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gac act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac tcg ggg gat tcg aag tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Lys Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gcc cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2584
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2584

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Lys Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2585
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2585
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cag cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gac act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gtt tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Val Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc act atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Thr Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tcc ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2586
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2586

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Val Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Thr Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2587
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2587
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cag cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca gac aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Asp Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tcg tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg cgg      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Arg         
                165                 170                 175             

ttc cta cat tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac ctg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Leu Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act cag aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gct ata gac cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Ala Ile Asp Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2588
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2588

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Asp Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Arg 
                165                 170                 175     


Phe Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Leu Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ala Ile Asp Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2589
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2589
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cag cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttt ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gtt tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Val Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tat cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gct gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Ala Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2590
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2590

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Val Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ala Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2591
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2591
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gaa gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gtt tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Val Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2592
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2592

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Val Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2593
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2593
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gtt tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Val Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tat cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac ctg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Leu Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt ata gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2594
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2594

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Val Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Leu Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2595
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2595
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cag cca atc gat aaa tac gct gtc gaa gat      288
Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gac act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac ctg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Leu Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2596
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2596

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Leu Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2597
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2597
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cag cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gtt tcg caa atg aag gag cga aag tcg ggg cac atc atc      384
Asn Ala Val Val Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac ctg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Leu Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt ata gac cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Asp Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2598
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2598

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Val Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Leu Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Asp Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2599
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2599
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cag cca atc gat aaa tac gct gtc gga gat      288
Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Gly Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2600
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2600

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Gly Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2601
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2601
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt act gtc gaa gct ctg cag atc aag cca ttt gct cta gcg      336
Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca gac aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Asp Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt tta      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2602
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2602

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Asp Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2603
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2603
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt act gtc gaa gct ctg cag atc aag cca ttt gct cta gcg      336
Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca gac aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Asp Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct att gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2604
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2604

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Asp Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2605
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2605
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gtt gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gcc gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg caa cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat gcc gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gaa cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gcc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac acg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttc ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt act ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2606
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2606

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2607
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2607
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gtt gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg caa cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac act ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt act ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2608
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2608

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2609
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2609
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gtt gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gaa cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc agc ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac act ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt act ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2610
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2610

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2611
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2611
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gtt gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat gcc gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tca caa atg aag gaa cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc agc ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac act ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt act ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2612
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2612

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2613
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2613
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gtt gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat gcc gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag cgc cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc agc ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gct tcg gct cga gct ggg gcc agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt act ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2614
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2614

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2615
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2615
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gtt gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc ggc gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Gly Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag cgc cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc agc ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac act ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt act ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2616
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2616

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Gly Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2617
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2617
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gtt gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc ggc gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Gly Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gaa cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc agc ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac act ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt act ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2618
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2618

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Gly Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2619
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2619
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gtt gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc ggt atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Gly Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag cgc cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc agc ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac act ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt act ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2620
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2620

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Gly Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2621
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2621
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa ccg gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat gcc gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gaa cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac act ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt act ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc gaa gtg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Glu Val Pro Glu                 
                245                 250                                 


<210>  2622
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2622

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Glu Val Pro Glu 
                245                 250                 


<210>  2623
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2623
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gag cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt act gtc gaa gct ctg cag atc aag cca ttt gct cta gcg      336
Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca gac aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Asp Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gcc ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

agg act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Arg Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2624
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2624

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Asp Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Arg Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2625
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2625
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gat cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Asp Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac act ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt act ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2626
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2626

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Asp Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2627
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2627
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agt gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2628
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2628

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2629
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2629
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca att agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc ggc gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Gly Asp         
                85                  90                  95              

tac agg gat gcc gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag agc cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Ser Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gct tcg gct cga gct ggg gcc agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac act ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt act ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc gtg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Val Pro Glu                 
                245                 250                                 


<210>  2630
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2630

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Gly Asp 
                85                  90                  95      


Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Ser Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Val Pro Glu 
                245                 250                 


<210>  2631
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2631
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca att agc gaa cag gaa cca gtt gaa ctg att gaa      192
Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg caa cca atc gat aaa tac gct gtc ggc gat      288
Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Gly Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt act ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2632
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2632

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Gly Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2633
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2633
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca att agc gaa cag gaa cca gtt gaa ctg att gaa      192
Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat gcc gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gaa cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc agc ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac act ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt act ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2634
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2634

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2635
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2635
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg att cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg caa cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg agt      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Ser         
    130                 135                 140                         

tac gct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac act ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt act ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2636
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2636

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Ser 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2637
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2637
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg att cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg caa cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat gcc gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag cgc cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac act ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tcc ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt act ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc gaa gtg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Glu Val Pro Glu                 
                245                 250                                 


<210>  2638
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2638

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Glu Val Pro Glu 
                245                 250                 


<210>  2639
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2639
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg att cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gaa cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg agt      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Ser         
    130                 135                 140                         

tac gct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac act ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt act ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2640
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2640

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Ser 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2641
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2641
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg att cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gcc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt act ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gcg gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Ala Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2642
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2642

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ala Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2643
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2643
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg att cca atg agc gaa cag gaa cca gtt gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg caa cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg agt      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Ser         
    130                 135                 140                         

tac gct tcg gct cga gct ggg gcc agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac act ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

agg act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Arg Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt act ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2644
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2644

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Ser 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Arg Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2645
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2645
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg att cca atg agc gaa cag gaa cca gtt gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg caa cca atc gat aaa tac gct gtc ggc gat      288
Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Gly Asp         
                85                  90                  95              

tac agg gat gcc gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag cgc cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt act ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gcg gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Ala Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2646
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2646

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Gly Asp 
                85                  90                  95      


Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ala Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2647
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2647
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg att cca atg agc gaa cag gaa cca gtt gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag cgc cga aag tcg ggg cat atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac act ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gaa ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt act ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2648
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2648

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2649
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2649
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg att cca atg agc gaa cag gaa cca gtt gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc agc ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac act ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt act ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc gaa atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Glu Met Pro Glu                 
                245                 250                                 


<210>  2650
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2650

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Glu Met Pro Glu 
                245                 250                 


<210>  2651
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2651
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg att cca atg agc gaa cag gaa cca gtt gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat gcc gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gaa cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt act ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2652
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2652

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2653
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2653
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg att cca atg agc gaa cag gaa cca gtt gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat gcc gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc agc ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt act ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2654
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2654

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2655
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2655
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg att cca atg agc gaa cag gaa cca gtt gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc ggc gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Gly Asp         
                85                  90                  95              

tac agg gat gcc gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag cgc cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac act ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt act ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc agc gtg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Ser Val Pro Glu                 
                245                 250                                 


<210>  2656
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2656

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Gly Asp 
                85                  90                  95      


Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Ser Val Pro Glu 
                245                 250                 


<210>  2657
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2657
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg att cca att agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg caa cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat gcc gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gaa cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc agc ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gct tcg gct cga gct ggg gcc agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac ctg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Leu Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2658
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2658

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Leu Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2659
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2659
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg att cca att agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat gcc gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gaa cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gcc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac act ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt act ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc gaa atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Glu Met Pro Glu                 
                245                 250                                 


<210>  2660
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2660

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Glu Met Pro Glu 
                245                 250                 


<210>  2661
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2661
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gac tta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Asp Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc ggc gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Gly Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gaa cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc agc ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac ctg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Leu Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2662
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2662

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Asp Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Gly Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Leu Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2663
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2663
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gtg cta gaa gct ttt gcc gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Val Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gtt gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agt aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat gcc gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag cgc cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gcc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac act ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt act ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc gaa gtg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Glu Val Pro Glu                 
                245                 250                                 


<210>  2664
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2664

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Val Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Glu Val Pro Glu 
                245                 250                 


<210>  2665
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2665
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gtg cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Val Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg act cca atg agc gaa cag gaa cca gtt gaa ctg att gaa      192
Pro Gln Leu Thr Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gaa cga aag tcg ggg cat atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc acc tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gcc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aag gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc gaa ata ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Glu Ile Pro Glu                 
                245                 250                                 


<210>  2666
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2666

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Val Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Thr Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Glu Ile Pro Glu 
                245                 250                 


<210>  2667
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2667
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gtg cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Val Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg act cca att agc gaa cag gaa cca gtt gaa ctg att gaa      192
Pro Gln Leu Thr Pro Ile Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg agt      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Ser         
    130                 135                 140                         

tac gct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac act ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt act ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc gaa atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Glu Met Pro Glu                 
                245                 250                                 


<210>  2668
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2668

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Val Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Thr Pro Ile Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Ser 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Glu Met Pro Glu 
                245                 250                 


<210>  2669
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2669
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gtg cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Val Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg att cca atg agc gaa cag gaa cca gtt gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg caa cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat gcc gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gaa cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gcc agt gca cta gct aac gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac act ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt act ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2670
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2670

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Val Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2671
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2671
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gtg cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Val Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg att cca atg agc gaa cag gaa cca gtt gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg caa cca atc gat aaa tac gct gtc ggc gat      288
Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Gly Asp         
                85                  90                  95              

tac agg gat gcc gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag cgc cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc agc ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac act ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gcg gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Ala Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2672
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2672

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Val Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Gly Asp 
                85                  90                  95      


Tyr Arg Asp Ala Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ala Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2673
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2673
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gtg cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Val Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg att cca atg agc gaa cag gaa cca gtt gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag cgc cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc agc ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg gcg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt act ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2674
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2674

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Val Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2675
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2675
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gtg cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Val Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg att cca atg agc gaa cag gaa cca gtt gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gaa cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg agt      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Ser         
    130                 135                 140                         

tac gct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac ctg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Leu Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc gaa atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Glu Met Pro Glu                 
                245                 250                                 


<210>  2676
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2676

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Val Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Ser 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Leu Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Glu Met Pro Glu 
                245                 250                 


<210>  2677
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2677
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gtg cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Val Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg att cca atg agc gaa cag gaa cca gtt gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc ggc gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Gly Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc agc ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gcc agt gca cta gct aac gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt act ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gcg gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Ala Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2678
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2678

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Val Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Gly Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ala Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2679
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2679
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gtt cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Val Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat gta ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ctg atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Leu Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act cag aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2680
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2680

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Val Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Leu Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2681
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2681
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag ggt gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Gly Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg act cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Thr Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac act ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt act ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc agc gtg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Ser Val Pro Glu                 
                245                 250                                 


<210>  2682
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2682

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Gly Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Thr Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Ser Val Pro Glu 
                245                 250                 


<210>  2683
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2683
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gac acg gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag aaa cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2684
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2684

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2685
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2685
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca gat aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Asp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg cgt      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Arg         
                165                 170                 175             

tat cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt cgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2686
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2686

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Asp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Arg 
                165                 170                 175     


Tyr Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2687
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2687
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2688
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2688

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2689
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2689
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2690
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2690

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2691
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2691
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggc atg gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Gly Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aaa cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tat cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt cgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2692
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2692

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2693
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2693
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggc atg gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Gly Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aaa cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2694
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2694

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2695
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2695
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gag tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gac atg gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tat cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2696
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2696

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2697
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2697
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc aac aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Asn Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggc atg gtc gaa gct ctg cag atc aag cca ttt gct cta gta      336
Tyr Arg Gly Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag aaa cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tat cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt cgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2698
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2698

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Asn Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2699
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2699
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gac atg atc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Met Ile Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2700
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2700

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Met Ile Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2701
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2701
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aaa cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc gtg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Val Pro Glu                 
                245                 250                                 


<210>  2702
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2702

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Val Pro Glu 
                245                 250                 


<210>  2703
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2703
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca gat aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Asp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg cgt      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Arg         
                165                 170                 175             

ttt cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2704
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2704

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Asp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Arg 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2705
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2705
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2706
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2706

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2707
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2707
atg agc acc gct att gtc acc aac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gag acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gac atg gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gat cga aag tca ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2708
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2708

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2709
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2709
atg agc acc gct att gtc acc aac gtc gaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Glu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca gtg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Val Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct ctg gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca cgt aag gag ctt tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct cgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Arg Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2710
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2710

Met Ser Thr Ala Ile Val Thr Asn Val Glu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Val Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Arg Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2711
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2711
atg agc acc gct att gtc acc aac gtc gag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Glu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atc agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag tcg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Ser Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggg atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2712
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2712

Met Ser Thr Ala Ile Val Thr Asn Val Glu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Ile Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Ser Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2713
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2713
atg agc acc gct att gtc acc aac gtc tct cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Ser His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gac acg atc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Ile Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg acc      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa gaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Glu Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt cgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2714
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2714

Met Ser Thr Ala Ile Val Thr Asn Val Ser His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Ile Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Glu Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2715
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2715
atg agc acc gct att gtc acc aac gtc tta cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gac gtc ggg gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Asp Val Gly Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca cgt aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2716
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2716

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Asp Val Gly Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2717
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2717
atg agc acc gct att gtc acc aac gtc tta cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gcc gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca cgt aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2718
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2718

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2719
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2719
atg agc acc gct att gtc acc aac gtc tta cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca cgt aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag gat aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Glu Asp Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac agt ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2720
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2720

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Asp Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2721
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2721
atg agc acc gct att gtc acc aac gtc tta cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gct ccg ttc ggg cca cgt aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2722
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2722

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2723
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2723
atg agc acc gct att gtc acc aac gtc tta cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gtt ctt ggt cgt gtc gat gtc ctg gtc tcc aac gat      240
Ala Val Thr Ser Val Leu Gly Arg Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gac gtc ggg gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Asp Val Gly Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca cgt aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2724
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2724

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Val Leu Gly Arg Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Asp Val Gly Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2725
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2725
atg agc acc gct att gtc acc aac gtc ttg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cac gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His His Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg att cca atg agc gaa cag gaa cca gtt gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag cgc cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac act ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt act ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2726
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2726

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His His Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2727
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2727
atg agc acc gct att gtc acc aac gtc ttg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gtt gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg caa cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat acc gtc gaa gct ctg cag atc aag cca ttt gct cta gta      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gaa cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac act ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt act ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2728
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2728

Met Ser Thr Ala Ile Val Thr Asn Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2729
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2729
atg agc acc gct att gtc acc aac gtt aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgt cca atc gat aaa tac gcg gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tca gga cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat att ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggt tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggt atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2730
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2730

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2731
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2731
atg agc acc gct att gtc acc aac gtt aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgt cca atc gat aaa tac gcg gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tca gga cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca ctg gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat att ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac tta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2732
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2732

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2733
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2733
atg agc acc gct att gtc acc aac gtt aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgt cca atc gat aaa tac gcg gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta ccg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Pro Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gcg aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggt tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2734
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2734

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Pro Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2735
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2735
atg agc acc gct att gtc acc aac gtt aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2736
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2736

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2737
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2737
atg agc acc gct att gtc acc aat gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg ccc gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tca tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2738
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2738

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2739
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2739
atg agc acc gct att gtc acc gac gtc ctg cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asp Val Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg att cca atg agc gaa cag gaa cca gtt gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc ggc gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Gly Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gcc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac act ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt act ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2740
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2740

Met Ser Thr Ala Ile Val Thr Asp Val Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Gly Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Thr Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2741
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2741
atg agc acc gct att gtc act aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gtt gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtt gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2742
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2742

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Val Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2743
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2743
atg agc acc gct gtg gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Val Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gcc ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gtt gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Val Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat acg gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gtc ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Val Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gtt cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Val Leu         
        195                 200                 205                     

caa cga cta ggg acc caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2744
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2744

Met Ser Thr Ala Val Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Val Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Val Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Val Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2745
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2745
atg agc acc gct gtg gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Val Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg ata gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat gag tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Glu Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat acg gtc gaa gca ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gcc ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2746
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2746

Met Ser Thr Ala Val Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Glu Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2747
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2747
atg agc acc gct gtg gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Val Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg ata gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat att ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aag tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2748
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2748

Met Ser Thr Ala Val Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2749
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2749
atg agc acc gct gtg gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Val Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aag tac act gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Thr Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2750
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2750

Met Ser Thr Ala Val Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Thr Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2751
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2751
atg agc acc gct gtg gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Val Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat att ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat gag tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Glu Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2752
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2752

Met Ser Thr Ala Val Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Glu Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2753
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2753
atg agc acc gct gtg gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Val Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gtt gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Val Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg ata gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg atc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Ile Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2754
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2754

Met Ser Thr Ala Val Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Val Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Ile Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2755
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2755
atg agc acc gct gtg gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Val Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gtt gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Val Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg ata gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg atc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Ile Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat gag tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Glu Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gtc ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Val Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2756
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2756

Met Ser Thr Ala Val Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Val Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Ile Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Glu Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Val Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2757
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2757
atg agc acc gct gtg gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Val Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gtt gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Val Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg ata gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat atg gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gtc ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Val Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2758
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2758

Met Ser Thr Ala Val Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Val Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Val Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2759
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2759
atg agc acc gct gtg gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Val Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gtt gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Val Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg ata gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat gag tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Glu Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gtc ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Val Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2760
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2760

Met Ser Thr Ala Val Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Val Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Glu Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Val Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2761
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2761
atg agc acc gct gtg gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Val Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gtt gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Val Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg ata gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat gag tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Glu Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat atg gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta ggg gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gtc ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Val Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gag gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Glu Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2762
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2762

Met Ser Thr Ala Val Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Val Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Glu Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Val Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Glu Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2763
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2763
atg agc acc gct gtg gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Val Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gtt gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Val Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg ata gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat att ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aag tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat acg gtc gaa gaa ctg cag atc aag cca ttt gct cta gcg      336
Tyr Arg Asp Thr Val Glu Glu Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gtc ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Val Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2764
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2764

Met Ser Thr Ala Val Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Val Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Glu Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Val Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2765
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2765
atg agc acc gct gtg gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Val Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gtt gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Val Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg ata gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat att ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat gag tac act gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Glu Tyr Thr Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gtc ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Val Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct aag gtg cgt aag ttg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Lys Val Arg Lys Leu Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2766
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2766

Met Ser Thr Ala Val Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Val Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Glu Tyr Thr Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Val Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Lys Val Arg Lys Leu Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2767
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2767
atg agc acc gct gtg gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Val Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gtt gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Val Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat atg gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2768
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2768

Met Ser Thr Ala Val Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Val Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2769
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2769
atg agc acc gct gtg gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Val Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gtt gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Val Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat att ctg atc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Ile Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aag tac act gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Thr Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga ctc ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2770
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2770

Met Ser Thr Ala Val Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Val Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Ile Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Thr Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2771
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2771
atg agc acc gct gtg gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Val Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gtt gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Val Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat att ctg atc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Ile Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aag tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat acg gtc gaa gca ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act cga aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Arg Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2772
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2772

Met Ser Thr Ala Val Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Val Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Ile Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Arg Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2773
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2773
atg agc acc gct gtg gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Val Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gtt gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Val Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat att ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat gag tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Glu Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga agg tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Arg Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc cct gtc ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Pro Val Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2774
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2774

Met Ser Thr Ala Val Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Val Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Glu Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Arg Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Pro Val Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2775
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2775
atg agc acc gct gtg gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Val Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gtt gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Val Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cgg gaa cca gct gaa ctg ata gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Arg Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat att ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat gag tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Glu Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gtc ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Val Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2776
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2776

Met Ser Thr Ala Val Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Val Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Arg Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Glu Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Val Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2777
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2777
atg agc acc gct gtg gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Val Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat ctg gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg ata gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat gag tac act gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Glu Tyr Thr Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc agg cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct tgg gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2778
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2778

Met Ser Thr Ala Val Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Leu Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Glu Tyr Thr Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala Trp Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2779
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2779
atg agc acc gct gtt gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Val Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct aat gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Asn Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2780
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2780

Met Ser Thr Ala Val Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Asn Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2781
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2781
atg agc acc gct gtt gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Val Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agt gaa cag gag cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ctg atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Leu Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc gtt ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Val Pro Glu                 
                245                 250                                 


<210>  2782
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2782

Met Ser Thr Ala Val Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Leu Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Val Pro Glu 
                245                 250                 


<210>  2783
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2783
atg agc acc gct gtt gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Val Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca gtg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Val Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aaa aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca aag aag gag att tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Lys Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa gag gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Glu Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc aaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Lys                 
                245                 250                                 


<210>  2784
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2784

Met Ser Thr Ala Val Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Val Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Lys Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Glu Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Lys 
                245                 250                 


<210>  2785
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2785
atg agc acc gct gtt gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Val Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gtt gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Val Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat atg gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag gag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag tac act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt acc ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2786
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2786

Met Ser Thr Ala Val Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Val Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Glu Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Tyr Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Thr Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2787
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2787
atg agc acc gct gtt gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Val Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa gcc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc aac aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Asn Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aaa cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt cgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2788
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2788

Met Ser Thr Ala Val Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Ala Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Asn Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2789
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2789
atg agc acc gtt att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Val Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat caa ctg aaa gct ttt gct aaa acc tac      144
Glu Ser Phe Lys His Gln Asp Gln Leu Lys Ala Phe Ala Lys Thr Tyr         
        35                  40                  45                      

cca cag ctg atc cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cag gtc gat gta ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly Gln Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc tat cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Tyr Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc act gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ctg ggg gaa ttg gtg gca ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu         
    210                 215                 220                         

gca tct ggc tcc tgt gat tat ttg act ggc cag gtg ttt tgc ttg aca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Thr         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc gac atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Asp Met Pro Glu                 
                245                 250                                 


<210>  2790
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2790

Met Ser Thr Val Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Gln Leu Lys Ala Phe Ala Lys Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly Gln Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Tyr Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Thr Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Ala Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Cys Leu Thr 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Asp Met Pro Glu 
                245                 250                 


<210>  2791
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2791
atg agc acc gtt att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Thr Val Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2792
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2792

Met Ser Thr Val Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2793
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2793
atg agc tcc gct att gtc acc aac gtc aaa cat ttt gga ggc atg ggt       48
Met Ser Ser Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg tgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Cys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cag cca atc gat aaa tac gct gtc ggg gat      288
Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Gly Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc cgc cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc gtt act tcg gct gcc ccg ttc ggg cca cgt aag gag atc tcg act      432
Phe Val Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cgg cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2794
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2794

Met Ser Ser Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Cys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Gly Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Val Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2795
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2795
atg agc tcc gct att gtc acc aac gtc aaa cat ttt gga ggc atg ggt       48
Met Ser Ser Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg tgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Cys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg gtt gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Val Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cag cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt act gtc gaa gct ctg cag atc cgc cca ttt gct cta gtg      336
Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca cgc aag gag att tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tat aat atc ccg gtg ttc gct atc gct ccg aag      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Lys         
                165                 170                 175             

ttc cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag atg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Met Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2796
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2796

Met Ser Ser Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Cys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Val Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Lys 
                165                 170                 175     


Phe Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Met Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2797
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2797
atg agc tcc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Ser Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cag cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca cgt aag gag atc tca act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag aac gtg gct cac gtg cgt aag atg act gct cta      624
Lys Thr Ser Pro Glu Asn Val Ala His Val Arg Lys Met Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2798
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2798

Met Ser Ser Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu Asn Val Ala His Val Arg Lys Met Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2799
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2799
atg agc tcc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Ser Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg gtt gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Val Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cag cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aac gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca cgt aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac act tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Thr Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttc cta cac tcg atc gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu His Ser Ile Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag aac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu Asn Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2800
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2800

Met Ser Ser Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Val Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Thr Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu His Ser Ile Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu Asn Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2801
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2801
atg agc tcc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Ser Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg gtt gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Val Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cag cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc gtt act tcg gct gcc ccg ttc ggg cca cgt aag gag att tcg act      432
Phe Val Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac tcg atc gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Ile Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg acc gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2802
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2802

Met Ser Ser Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Val Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Val Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Ile Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2803
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2803
atg agc tcc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Ser Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg gtt gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Val Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca cgt aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac agt tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag aac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu Asn Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2804
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2804

Met Ser Ser Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Val Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu Asn Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2805
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2805
atg agc tcc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Ser Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg gtt gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Val Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

att gcg cct gtg gaa tgg cag cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc gtt act tcg gct gcc ccg ttc ggg cca cgt aag gag att tcg act      432
Phe Val Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac agt tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gtg tac aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Val Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac tcg atc gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Ile Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2806
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2806

Met Ser Ser Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Val Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Val Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Val Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Ile Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2807
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2807
atg agc tcc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Ser Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gat cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Asp Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc agc gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Ser Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cag cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc aaa gct ctg cag atc cgc cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Lys Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cgc atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly Arg Ile Ile         
        115                 120                 125                     

ttc gtt act tcg gct gcc ccg ttc ggg cca cgt aag gag atc tcg act      432
Phe Val Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gcc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gtg gat aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Val Asp Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac tcg atc gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Ile Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2808
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2808

Met Ser Ser Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Asp Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Ser Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Lys Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly Arg Ile Ile 
        115                 120                 125             


Phe Val Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Val Asp Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Ile Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2809
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2809
atg agc tcc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Ser Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gat cag gaa cca gct gaa ctg gtt gaa      192
Pro Gln Leu Ile Pro Met Ser Asp Gln Glu Pro Ala Glu Leu Val Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aac gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca cgt aag gag ctt tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag atg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Met Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2810
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2810

Met Ser Ser Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Asp Gln Glu Pro Ala Glu Leu Val Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Met Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2811
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2811
atg agc tcc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Ser Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat act gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gag acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg gtt gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Val Glu         
    50                  55                  60                          

gct gtc acc agc gcc ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt act gtc gaa gct ctg cag atc cgc cca ttt gct cta gtg      336
Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aac gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc gtt act tcg gct gcc ccg ttc ggg cca cgt aag gag atc tcg act      432
Phe Val Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac agt tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2812
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2812

Met Ser Ser Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Val Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Val Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2813
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2813
atg agc tcc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Ser Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg tgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Cys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cag cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc cgc cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aac gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca cgt aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac agt tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gtg tat aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Val Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag aac gtg gct cac gtg cgt aag atg act gct cta      624
Lys Thr Ser Pro Glu Asn Val Ala His Val Arg Lys Met Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act cga aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Arg Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2814
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2814

Met Ser Ser Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Cys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Val Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu Asn Val Ala His Val Arg Lys Met Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Arg Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2815
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2815
atg agc tcc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Ser Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg tgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Cys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg gtt gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Val Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cag cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gcc cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc gtt act tcg gct gcc ccg ttc ggg cca cgt aag gag atc tcg act      432
Phe Val Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac agt tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2816
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2816

Met Ser Ser Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Cys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Val Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Val Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2817
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2817
atg agc tcc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Ser Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg tgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Cys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg gtt gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Val Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cag cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aac gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc gtt act tcg gct gcc ccg ttc ggg cca cgt aag gag atc tcg act      432
Phe Val Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2818
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2818

Met Ser Ser Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Cys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Val Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Val Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2819
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2819
atg agc tcc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Ser Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg tgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Cys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg gtt gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Val Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cag cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca cgt aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gtg gat aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Val Asp Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag aac gtg gcc cac gtg cgt aag atg act gct cta      624
Lys Thr Ser Pro Glu Asn Val Ala His Val Arg Lys Met Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2820
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2820

Met Ser Ser Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Cys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Val Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Val Asp Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu Asn Val Ala His Val Arg Lys Met Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2821
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2821
atg agc tcc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Ser Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg tgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Cys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg gtt gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Val Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca cgt aag gag att tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag gat aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Glu Asp Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag aac gtg gct cac gtg cgt aag atg act gct cta      624
Lys Thr Ser Pro Glu Asn Val Ala His Val Arg Lys Met Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2822
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2822

Met Ser Ser Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Cys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Val Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Asp Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu Asn Val Ala His Val Arg Lys Met Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2823
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2823
atg agc tcc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Ser Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg tgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Cys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg gtt gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Val Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca cgt aag gag att tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gtg tat aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Val Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2824
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2824

Met Ser Ser Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Cys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Val Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Val Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2825
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2825
atg agc tcc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Ser Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg tgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Cys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg gtt gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Val Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt act gtc gaa gct ctg cag atc cgc cca ttt gct cta gtg      336
Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca cgt aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca tta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag aac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu Asn Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2826
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2826

Met Ser Ser Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Cys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Val Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu Asn Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2827
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2827
atg agc tcc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Ser Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg tgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Cys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg gtt gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Val Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt act gtc gaa gct ctg cag atc cgc cca ttt gct cta gtg      336
Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca cgt aag gag att tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag gat aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Glu Asp Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag aac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu Asn Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tac ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2828
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2828

Met Ser Ser Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Cys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Val Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Asp Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu Asn Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2829
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2829
atg agc tcc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Ser Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg tgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Cys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg gtt gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Val Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

att gcg cct gtg gaa tgg cag cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aac gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc gtt act tcg gct gcc ccg ttc ggg cca cgt aag gag ctt tcg act      432
Phe Val Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tat aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttc cta cac tcg atc gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu His Ser Ile Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag atg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Met Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg gga gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2830
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2830

Met Ser Ser Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Cys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Val Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Gln Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Val Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu His Ser Ile Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Met Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2831
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2831
atg agc tcc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Ser Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg tgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Cys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg gtt gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Val Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

att gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc gtt act tcg gct gcc ccg ttc ggg cca cgt aag gag atc tcg act      432
Phe Val Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttc cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gga ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Gly Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc tct ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Ser Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2832
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2832

Met Ser Ser Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Cys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Val Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Val Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Gly Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Ser Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2833
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2833
atg agc tcc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Ser Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg tgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Cys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gat cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Asp Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc agg cca ttt gct cta gtg      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa gtg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Val Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca cgt aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac tcg agg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Arg Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag aac gtg gct cac gtg cgt aag atg act gct cta      624
Lys Thr Ser Pro Glu Asn Val Ala His Val Arg Lys Met Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gcc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2834
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2834

Met Ser Ser Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Cys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Asp Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Val Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Arg Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu Asn Val Ala His Val Arg Lys Met Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Ala Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2835
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2835
atg agc tcc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Ser Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg tgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Cys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gat cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Asp Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt act gtc gaa gct ctg cag atc cag cca ttt gct cta gtg      336
Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Gln Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca aag aag gag att tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Lys Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc cca gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttc cta cac tcg atc gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu His Ser Ile Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag atg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Met Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2836
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2836

Met Ser Ser Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Cys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Asp Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Gln Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Lys Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu His Ser Ile Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Met Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2837
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2837
atg agc tcc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Ser Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg tgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Cys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gat cag gaa cca gct gaa ctg gtt gaa      192
Pro Gln Leu Ile Pro Met Ser Asp Gln Glu Pro Ala Glu Leu Val Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt act gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc gtt act tcg gct gcc ccg ttc ggg cca cgt aag gag atc tcg act      432
Phe Val Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gcc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag gat aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Asp Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttc cta cac tcg atc gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu His Ser Ile Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag aac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu Asn Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2838
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2838

Met Ser Ser Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Cys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Asp Gln Glu Pro Ala Glu Leu Val Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Val Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Asp Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu His Ser Ile Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu Asn Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2839
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2839
atg agc tcc gct att gtc acc aac gtc aaa cat ttt gga ggt atg ggt       48
Met Ser Ser Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg tgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Cys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gat cag gaa cca gct gaa ctg gtt gaa      192
Pro Gln Leu Ile Pro Met Ser Asp Gln Glu Pro Ala Glu Leu Val Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt act gtc gaa gct ctg cag atc cgc cca ttt gct cta gtg      336
Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca cgt aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg acc agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aat      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttc cta cac tcg atc gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu His Ser Ile Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2840
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2840

Met Ser Ser Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Cys Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Asp Gln Glu Pro Ala Glu Leu Val Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Thr Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu His Ser Ile Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2841
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2841
atg agc tcc gct att gtc acc aac gtc gaa cat ttt gga ggt atg ggt       48
Met Ser Ser Ala Ile Val Thr Asn Val Glu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gat cag gaa cca gct gaa ctg gtt gaa      192
Pro Gln Leu Ile Pro Met Ser Asp Gln Glu Pro Ala Glu Leu Val Glu         
    50                  55                  60                          

gct gtc acc agc gct ctt ggt cat gtc gat gtc ctg gtc agc aac gat      240
Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggt act gtc gaa gct ctg cag atc cgc cca ttt gct cta gtg      336
Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag aag cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca cgt aag gag atc tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gct agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag gat aat atc ccg gcg ttc gct atc gct ccg gag      528
Lys Glu Leu Gly Glu Asp Asn Ile Pro Ala Phe Ala Ile Ala Pro Glu         
                165                 170                 175             

tac cta cac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtc atc gaa cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2842
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2842

Met Ser Ser Ala Ile Val Thr Asn Val Glu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Asp Gln Glu Pro Ala Glu Leu Val Glu 
    50                  55                  60                  


Ala Val Thr Ser Ala Leu Gly His Val Asp Val Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Thr Val Glu Ala Leu Gln Ile Arg Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Lys Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Arg Lys Glu Ile Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Asp Asn Ile Pro Ala Phe Ala Ile Ala Pro Glu 
                165                 170                 175     


Tyr Leu His Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Ile Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2843
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2843
atg agt acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat tta act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2844
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2844

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2845
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2845
atg agt ccc gct att gtc acc gac ggc ctg cat ttt gga ggt atg ggt       48
Met Ser Pro Ala Ile Val Thr Asp Gly Leu His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc acc gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Thr Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg ggc atg gtc gaa gct ctg cag atc aag cca ttt gct cta gtg      336
Tyr Arg Gly Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val         
            100                 105                 110                 

aat gct gtc gct tcg caa atg aag gat cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc ccg ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac tct tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

ttt cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt cgt ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2846
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2846

Met Ser Pro Ala Ile Val Thr Asp Gly Leu His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Thr Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Gly Met Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Val 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Asp Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Pro Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ser Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Phe Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Arg Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


<210>  2847
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HHDH variant


<220>
<221>  CDS
<222>  (1)..(768)

<400>  2847
atg agc acc gct att gtc acc aac gtc aag cat ttt gga ggt atg ggt       48
Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly         
1               5                   10                  15              

agc gct ctg cgt ctg agc gaa gct ggt cat acc gtc gct tgc cat gat       96
Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp         
            20                  25                  30                  

gaa agc ttt aag cat cag gat gaa cta gaa gct ttt gct gaa acc tac      144
Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr         
        35                  40                  45                      

cca cag ctg ata cca atg agc gaa cag gaa cca gct gaa ctg att gaa      192
Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu         
    50                  55                  60                          

gct gtc aat agc gcc ctt ggt cat gtc gat atc ctg gtc agc aac gat      240
Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp         
65                  70                  75                  80          

atc gcg cct gtg gaa tgg cgg cca atc gat aaa tac gct gtc gag gat      288
Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp         
                85                  90                  95              

tac agg gat act gtc gaa gct ctg cag atc aag cca ttt gct cta gca      336
Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala         
            100                 105                 110                 

aat gcc gtc gct tcg caa atg aag cgt cga aag tcg ggg cac atc atc      384
Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile         
        115                 120                 125                     

ttc atc act tcg gct gcc tca ttc ggg cca tgg aag gag cta tcg act      432
Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr         
    130                 135                 140                         

tac gca tcg gct cga gct ggg gcg agt gca cta gct aat gct cta tcg      480
Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser         
145                 150                 155                 160         

aag gag cta gga gag tac aat atc ccg gtg ttc gct atc gct ccg aac      528
Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn         
                165                 170                 175             

gcc cta gac tcg ggg gat tcg ccg tac tat tac ccc tct gag ccg tgg      576
Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp         
            180                 185                 190                 

aag act tct ccg gag cac gtg gct cac gtg cgt aag gtg act gct cta      624
Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu         
        195                 200                 205                     

caa cga cta ggg act caa aaa gag ttg ggg gaa ttg gtg acg ttt ttg      672
Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu         
    210                 215                 220                         

gca tct ggc tct tgt gat tat ttg act ggc cag gtg ttt tgg ttg gca      720
Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala         
225                 230                 235                 240         

ggc ggc ttt ccc gtt gta gag cgt tgg ccc ggc atg ccc gaa taa tga      768
Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu                 
                245                 250                                 


<210>  2848
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2848

Met Ser Thr Ala Ile Val Thr Asn Val Lys His Phe Gly Gly Met Gly 
1               5                   10                  15      


Ser Ala Leu Arg Leu Ser Glu Ala Gly His Thr Val Ala Cys His Asp 
            20                  25                  30          


Glu Ser Phe Lys His Gln Asp Glu Leu Glu Ala Phe Ala Glu Thr Tyr 
        35                  40                  45              


Pro Gln Leu Ile Pro Met Ser Glu Gln Glu Pro Ala Glu Leu Ile Glu 
    50                  55                  60                  


Ala Val Asn Ser Ala Leu Gly His Val Asp Ile Leu Val Ser Asn Asp 
65                  70                  75                  80  


Ile Ala Pro Val Glu Trp Arg Pro Ile Asp Lys Tyr Ala Val Glu Asp 
                85                  90                  95      


Tyr Arg Asp Thr Val Glu Ala Leu Gln Ile Lys Pro Phe Ala Leu Ala 
            100                 105                 110         


Asn Ala Val Ala Ser Gln Met Lys Arg Arg Lys Ser Gly His Ile Ile 
        115                 120                 125             


Phe Ile Thr Ser Ala Ala Ser Phe Gly Pro Trp Lys Glu Leu Ser Thr 
    130                 135                 140                 


Tyr Ala Ser Ala Arg Ala Gly Ala Ser Ala Leu Ala Asn Ala Leu Ser 
145                 150                 155                 160 


Lys Glu Leu Gly Glu Tyr Asn Ile Pro Val Phe Ala Ile Ala Pro Asn 
                165                 170                 175     


Ala Leu Asp Ser Gly Asp Ser Pro Tyr Tyr Tyr Pro Ser Glu Pro Trp 
            180                 185                 190         


Lys Thr Ser Pro Glu His Val Ala His Val Arg Lys Val Thr Ala Leu 
        195                 200                 205             


Gln Arg Leu Gly Thr Gln Lys Glu Leu Gly Glu Leu Val Thr Phe Leu 
    210                 215                 220                 


Ala Ser Gly Ser Cys Asp Tyr Leu Thr Gly Gln Val Phe Trp Leu Ala 
225                 230                 235                 240 


Gly Gly Phe Pro Val Val Glu Arg Trp Pro Gly Met Pro Glu 
                245                 250                 


