                         SEQUENCE LISTING



<110>  VIB vzw



<120>  THE MODULATION OF PHAGOCYTOSIS IN NEURONS



<130>  WAN/TLN/V190



<150>  EP 04077519.9

<151>  2004-09-13



<160>  2     



<170>  PatentIn version 3.1



<210>  1

<211>  3000

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (66)..(2840)

<223>  



<220>

<221>  misc_feature

<222>  (125)..(419)

<223>  first Immunoglonulin-like domain



<220>

<221>  misc_feature

<222>  (2556)..(2645)

<223>  transmembrane region



<400>  1
ccgtcctcta gcccagctcc tcggctcgcg ctctcctcgc ctcctgtgct ttccccgccg     60

cggcg atg cca ggg cct tcg cca ggg ctg cgc cgg gcg cta ctc ggc ctc    110
      Met Pro Gly Pro Ser Pro Gly Leu Arg Arg Ala Leu Leu Gly Leu       
      1               5                   10                  15        

tgg gct gct ctg ggc ctg ggg ctc ttc ggc ctc tca gcg gtc tcg cag      158
Trp Ala Ala Leu Gly Leu Gly Leu Phe Gly Leu Ser Ala Val Ser Gln         
                20                  25                  30              

gag ccc ttc tgg gcg gac ctg cag cct cgc gtg gcg ttc gtg gag cgc      206
Glu Pro Phe Trp Ala Asp Leu Gln Pro Arg Val Ala Phe Val Glu Arg         
            35                  40                  45                  

ggg ggc tcg ctg tgg ctg aat tgc agc acc aac tgc cct cgg ccg gag      254
Gly Gly Ser Leu Trp Leu Asn Cys Ser Thr Asn Cys Pro Arg Pro Glu         
        50                  55                  60                      

cgc ggt ggc ctg gag acc tcg ctg cgc cga aac ggg acc cag agg ggt      302
Arg Gly Gly Leu Glu Thr Ser Leu Arg Arg Asn Gly Thr Gln Arg Gly         
    65                  70                  75                          

ttg cgt tgg ttg gcg cgg cag ctg gtg gac att cgc gag ccg gag act      350
Leu Arg Trp Leu Ala Arg Gln Leu Val Asp Ile Arg Glu Pro Glu Thr         
80                  85                  90                  95          

cag ccc gtc tgc ttc ttc cgc tgc gcg cgg cgc aca cta cag gcg cgt      398
Gln Pro Val Cys Phe Phe Arg Cys Ala Arg Arg Thr Leu Gln Ala Arg         
                100                 105                 110             

ggg ctc att cgc act ttc cag cga cca gat cgc gta gag ctg atg ccg      446
Gly Leu Ile Arg Thr Phe Gln Arg Pro Asp Arg Val Glu Leu Met Pro         
            115                 120                 125                 

ctg cct ccc tgg cag ccg gtg ggc gag aac ttc acc ctg agc tgt agg      494
Leu Pro Pro Trp Gln Pro Val Gly Glu Asn Phe Thr Leu Ser Cys Arg         
        130                 135                 140                     

gtc ccc ggc gcc ggg ccc cgt gcg agc ctc acg ctg acc ctg ctg cgg      542
Val Pro Gly Ala Gly Pro Arg Ala Ser Leu Thr Leu Thr Leu Leu Arg         
    145                 150                 155                         

ggc gcc cag gag ctg atc cgc cgc agc ttc gcc ggt gaa cca ccc cga      590
Gly Ala Gln Glu Leu Ile Arg Arg Ser Phe Ala Gly Glu Pro Pro Arg         
160                 165                 170                 175         

gcg cgg ggc gcg gtg ctc aca gcc acg gta ctg gct cgg agg gag gac      638
Ala Arg Gly Ala Val Leu Thr Ala Thr Val Leu Ala Arg Arg Glu Asp         
                180                 185                 190             

cat gga gcc aat ttc tcg tgt cgc gcc gag ctg gac ctg cgg ccg cac      686
His Gly Ala Asn Phe Ser Cys Arg Ala Glu Leu Asp Leu Arg Pro His         
            195                 200                 205                 

gga ctg gga ctg ttt gaa aac agc tcg gcc ccc aga gag ctc cga acc      734
Gly Leu Gly Leu Phe Glu Asn Ser Ser Ala Pro Arg Glu Leu Arg Thr         
        210                 215                 220                     

ttc tcc ctg tct ccg gat gcc ccg cgc ctc gct gct ccc cgg ctc ttg      782
Phe Ser Leu Ser Pro Asp Ala Pro Arg Leu Ala Ala Pro Arg Leu Leu         
    225                 230                 235                         

gaa gtt ggc tcg gaa agg ccc gtg agc tgc act ctg gac gga ctg ttt      830
Glu Val Gly Ser Glu Arg Pro Val Ser Cys Thr Leu Asp Gly Leu Phe         
240                 245                 250                 255         

cca gcc tca gag gcc agg gtc tac ctc gca ctg ggg gac cag aat ctg      878
Pro Ala Ser Glu Ala Arg Val Tyr Leu Ala Leu Gly Asp Gln Asn Leu         
                260                 265                 270             

agt cct gat gtc acc ctc gaa ggg gac gca ttc gtg gcc act gcc aca      926
Ser Pro Asp Val Thr Leu Glu Gly Asp Ala Phe Val Ala Thr Ala Thr         
            275                 280                 285                 

gcc aca gct agc gca gag cag gag ggt gcc agg cag ctg atc tgc aac      974
Ala Thr Ala Ser Ala Glu Gln Glu Gly Ala Arg Gln Leu Ile Cys Asn         
        290                 295                 300                     

gtc acc ctg ggg ggc gaa aac cgg gag acc cgg gag aac gtg acc atc     1022
Val Thr Leu Gly Gly Glu Asn Arg Glu Thr Arg Glu Asn Val Thr Ile         
    305                 310                 315                         

tac agc ttc ccg gca cca ctc ctg acc ctg agc gaa ccc agc gtc tcc     1070
Tyr Ser Phe Pro Ala Pro Leu Leu Thr Leu Ser Glu Pro Ser Val Ser         
320                 325                 330                 335         

gag ggg cag atg gtg aca gta acc tgc gca gct ggg acc caa gct ctg     1118
Glu Gly Gln Met Val Thr Val Thr Cys Ala Ala Gly Thr Gln Ala Leu         
                340                 345                 350             

gtc aca ctg gag gga gtt cca gcc gcg gtc ccg ggg cag ccc gcc cag     1166
Val Thr Leu Glu Gly Val Pro Ala Ala Val Pro Gly Gln Pro Ala Gln         
            355                 360                 365                 

ctt cag cta aat gcc acc gag aac gac gac aga cgc agc ttc ttc tgc     1214
Leu Gln Leu Asn Ala Thr Glu Asn Asp Asp Arg Arg Ser Phe Phe Cys         
        370                 375                 380                     

gac gcc acc ctc gat gtg gac ggg gag acc ctg atc aag aac agg agc     1262
Asp Ala Thr Leu Asp Val Asp Gly Glu Thr Leu Ile Lys Asn Arg Ser         
    385                 390                 395                         

gca gag ctt cgt gtc cta tac gct ccc cgg cta gac gat tcg gac tgc     1310
Ala Glu Leu Arg Val Leu Tyr Ala Pro Arg Leu Asp Asp Ser Asp Cys         
400                 405                 410                 415         

ccc agg agt tgg acg tgg ccc gag ggc cca gag cag acg ctg cgc tgc     1358
Pro Arg Ser Trp Thr Trp Pro Glu Gly Pro Glu Gln Thr Leu Arg Cys         
                420                 425                 430             

gag gcc cgc ggg aac cca gaa ccc tca gtg cac tgt gcg cgc tcc gac     1406
Glu Ala Arg Gly Asn Pro Glu Pro Ser Val His Cys Ala Arg Ser Asp         
            435                 440                 445                 

ggc ggg gcc gtg ctg gct ctg ggc ctg ctg ggt cca gtc act cgg gcg     1454
Gly Gly Ala Val Leu Ala Leu Gly Leu Leu Gly Pro Val Thr Arg Ala         
        450                 455                 460                     

ctc tca ggc act tac cgc tgc aag gcg gcc aat gat caa ggc gag gcg     1502
Leu Ser Gly Thr Tyr Arg Cys Lys Ala Ala Asn Asp Gln Gly Glu Ala         
    465                 470                 475                         

gtc aag gac gta acg cta acg gtg gag tac gca cca gcg ctg gac agc     1550
Val Lys Asp Val Thr Leu Thr Val Glu Tyr Ala Pro Ala Leu Asp Ser         
480                 485                 490                 495         

gtg ggc tgc cca gaa cgc att act tgg ctg gag gga aca gaa gcc tcg     1598
Val Gly Cys Pro Glu Arg Ile Thr Trp Leu Glu Gly Thr Glu Ala Ser         
                500                 505                 510             

ctg agc tgt gtg gcg cac ggg gta ccg ccg cct gat gtg atc tgc gtg     1646
Leu Ser Cys Val Ala His Gly Val Pro Pro Pro Asp Val Ile Cys Val         
            515                 520                 525                 

cgc tct gga gaa ctc ggg gcc gtc atc gag ggg ctg ttg cgt gtg gcc     1694
Arg Ser Gly Glu Leu Gly Ala Val Ile Glu Gly Leu Leu Arg Val Ala         
        530                 535                 540                     

cgg gag cat gcg ggc act tac cgc tgc gaa gcc acc aac cct cgg ggc     1742
Arg Glu His Ala Gly Thr Tyr Arg Cys Glu Ala Thr Asn Pro Arg Gly         
    545                 550                 555                         

tct gcg gcc aaa aat gtg gcc gtc acg gtg gaa tat ggc ccc agg ttt     1790
Ser Ala Ala Lys Asn Val Ala Val Thr Val Glu Tyr Gly Pro Arg Phe         
560                 565                 570                 575         

gag gag ccg agc tgc ccc agc aat tgg aca tgg gtg gaa gga tct ggg     1838
Glu Glu Pro Ser Cys Pro Ser Asn Trp Thr Trp Val Glu Gly Ser Gly         
                580                 585                 590             

cgc ctg ttt tcc tgt gag gtc gat ggg aag cca cag cca agc gtg aag     1886
Arg Leu Phe Ser Cys Glu Val Asp Gly Lys Pro Gln Pro Ser Val Lys         
            595                 600                 605                 

tgc gtg ggc tcc ggg ggc gcc act gag ggg gtg ctg ctg ccg ctg gca     1934
Cys Val Gly Ser Gly Gly Ala Thr Glu Gly Val Leu Leu Pro Leu Ala         
        610                 615                 620                     

ccc cca gac cct agt ccc aga gct ccc aga atc cct aga gtc ctg gca     1982
Pro Pro Asp Pro Ser Pro Arg Ala Pro Arg Ile Pro Arg Val Leu Ala         
    625                 630                 635                         

ccc ggt atc tac gtc tgc aac gcc acc aac cgc cac ggc tcc gtg gcc     2030
Pro Gly Ile Tyr Val Cys Asn Ala Thr Asn Arg His Gly Ser Val Ala         
640                 645                 650                 655         

aaa aca gtc gtc gtg agc gcg gag tcg cca ccg gag atg gat gaa tct     2078
Lys Thr Val Val Val Ser Ala Glu Ser Pro Pro Glu Met Asp Glu Ser         
                660                 665                 670             

acc tgc cca agt cac cag acg tgg ctg gaa ggg gct gag gct tcc gcg     2126
Thr Cys Pro Ser His Gln Thr Trp Leu Glu Gly Ala Glu Ala Ser Ala         
            675                 680                 685                 

ctg gcc tgc gcc gcc cgg ggt cgc cct tcc cca gga gtg cgc tgc tct     2174
Leu Ala Cys Ala Ala Arg Gly Arg Pro Ser Pro Gly Val Arg Cys Ser         
        690                 695                 700                     

cgg gaa ggc atc cca tgg cct gag cag cag cgc gtg tcc cga gag gac     2222
Arg Glu Gly Ile Pro Trp Pro Glu Gln Gln Arg Val Ser Arg Glu Asp         
    705                 710                 715                         

gcg ggc act tac cac tgt gtg gcc acc aat gcg cat ggc acg gac tcc     2270
Ala Gly Thr Tyr His Cys Val Ala Thr Asn Ala His Gly Thr Asp Ser         
720                 725                 730                 735         

cgg acc gtc act gtg ggc gtg gaa tac cgg cca gtg gtg gcc gaa ctt     2318
Arg Thr Val Thr Val Gly Val Glu Tyr Arg Pro Val Val Ala Glu Leu         
                740                 745                 750             

gct gcc tcg ccc cct gga ggc gtg cgc cca gga gga aac ttc acg ttg     2366
Ala Ala Ser Pro Pro Gly Gly Val Arg Pro Gly Gly Asn Phe Thr Leu         
            755                 760                 765                 

acc tgc cgc gcg gag gcc tgg cct cca gcc cag atc agc tgg cgc gcg     2414
Thr Cys Arg Ala Glu Ala Trp Pro Pro Ala Gln Ile Ser Trp Arg Ala         
        770                 775                 780                     

ccc ccg ggg gcc ctc aac atc ggc ctg tcg agc aac aac agc aca ctg     2462
Pro Pro Gly Ala Leu Asn Ile Gly Leu Ser Ser Asn Asn Ser Thr Leu         
    785                 790                 795                         

agc gtg gca ggc gcc atg gga agc cac ggc ggc gag tac gag tgc gca     2510
Ser Val Ala Gly Ala Met Gly Ser His Gly Gly Glu Tyr Glu Cys Ala         
800                 805                 810                 815         

cgc acc aac gcg cac ggg cgc cac gcg cgg cgc atc acg gtg cgc gtg     2558
Arg Thr Asn Ala His Gly Arg His Ala Arg Arg Ile Thr Val Arg Val         
                820                 825                 830             

gcc ggt ccg tgg cta tgg gtc gcc gtg ggc ggc gcg gcg ggg ggc gcg     2606
Ala Gly Pro Trp Leu Trp Val Ala Val Gly Gly Ala Ala Gly Gly Ala         
            835                 840                 845                 

gcg ctg ctg gcc gcg ggg gcc ggc ctg gcc ttc tac gtg cag tcc acc     2654
Ala Leu Leu Ala Ala Gly Ala Gly Leu Ala Phe Tyr Val Gln Ser Thr         
        850                 855                 860                     

gcc tgc aag aag ggc gag tac aac gtg cag gag gcc gag agc tca ggc     2702
Ala Cys Lys Lys Gly Glu Tyr Asn Val Gln Glu Ala Glu Ser Ser Gly         
    865                 870                 875                         

gag gcc gtg tgt ctc aac gga gcg ggc ggc ggc gct ggc ggg gcg gca     2750
Glu Ala Val Cys Leu Asn Gly Ala Gly Gly Gly Ala Gly Gly Ala Ala         
880                 885                 890                 895         

ggc gcg gag ggc gga ccc gag gcg gcg ggg ggc gcg gcc gag tcg ccg     2798
Gly Ala Glu Gly Gly Pro Glu Ala Ala Gly Gly Ala Ala Glu Ser Pro         
                900                 905                 910             

gcg gag ggc gag gtc ttc gcc ata cag ctg aca tcg gcg tga             2840
Ala Glu Gly Glu Val Phe Ala Ile Gln Leu Thr Ser Ala                     
            915                 920                                     

gccgctcccc tctccccgcg ggccggggga cgccccccag actcacacgg gggcttattt   2900

attgctttat ttatttactt attcatttat ttatgtattc aactccaagg gcgtcacccc   2960

cattttctac ccatcccctc aataaagttt ttataaagga                         3000


<210>  2

<211>  924

<212>  PRT

<213>  Homo sapiens



<220>

<221>  misc_feature

<222>  (125)..(419)

<223>  first Immunoglonulin-like domain

<220>

<221>  misc_feature

<222>  (2556)..(2645)

<223>  transmembrane region

<400>  2

Met Pro Gly Pro Ser Pro Gly Leu Arg Arg Ala Leu Leu Gly Leu Trp 
1               5                   10                  15      


Ala Ala Leu Gly Leu Gly Leu Phe Gly Leu Ser Ala Val Ser Gln Glu 
            20                  25                  30          


Pro Phe Trp Ala Asp Leu Gln Pro Arg Val Ala Phe Val Glu Arg Gly 
        35                  40                  45              


Gly Ser Leu Trp Leu Asn Cys Ser Thr Asn Cys Pro Arg Pro Glu Arg 
    50                  55                  60                  


Gly Gly Leu Glu Thr Ser Leu Arg Arg Asn Gly Thr Gln Arg Gly Leu 
65                  70                  75                  80  


Arg Trp Leu Ala Arg Gln Leu Val Asp Ile Arg Glu Pro Glu Thr Gln 
                85                  90                  95      


Pro Val Cys Phe Phe Arg Cys Ala Arg Arg Thr Leu Gln Ala Arg Gly 
            100                 105                 110         


Leu Ile Arg Thr Phe Gln Arg Pro Asp Arg Val Glu Leu Met Pro Leu 
        115                 120                 125             


Pro Pro Trp Gln Pro Val Gly Glu Asn Phe Thr Leu Ser Cys Arg Val 
    130                 135                 140                 


Pro Gly Ala Gly Pro Arg Ala Ser Leu Thr Leu Thr Leu Leu Arg Gly 
145                 150                 155                 160 


Ala Gln Glu Leu Ile Arg Arg Ser Phe Ala Gly Glu Pro Pro Arg Ala 
                165                 170                 175     


Arg Gly Ala Val Leu Thr Ala Thr Val Leu Ala Arg Arg Glu Asp His 
            180                 185                 190         


Gly Ala Asn Phe Ser Cys Arg Ala Glu Leu Asp Leu Arg Pro His Gly 
        195                 200                 205             


Leu Gly Leu Phe Glu Asn Ser Ser Ala Pro Arg Glu Leu Arg Thr Phe 
    210                 215                 220                 


Ser Leu Ser Pro Asp Ala Pro Arg Leu Ala Ala Pro Arg Leu Leu Glu 
225                 230                 235                 240 


Val Gly Ser Glu Arg Pro Val Ser Cys Thr Leu Asp Gly Leu Phe Pro 
                245                 250                 255     


Ala Ser Glu Ala Arg Val Tyr Leu Ala Leu Gly Asp Gln Asn Leu Ser 
            260                 265                 270         


Pro Asp Val Thr Leu Glu Gly Asp Ala Phe Val Ala Thr Ala Thr Ala 
        275                 280                 285             


Thr Ala Ser Ala Glu Gln Glu Gly Ala Arg Gln Leu Ile Cys Asn Val 
    290                 295                 300                 


Thr Leu Gly Gly Glu Asn Arg Glu Thr Arg Glu Asn Val Thr Ile Tyr 
305                 310                 315                 320 


Ser Phe Pro Ala Pro Leu Leu Thr Leu Ser Glu Pro Ser Val Ser Glu 
                325                 330                 335     


Gly Gln Met Val Thr Val Thr Cys Ala Ala Gly Thr Gln Ala Leu Val 
            340                 345                 350         


Thr Leu Glu Gly Val Pro Ala Ala Val Pro Gly Gln Pro Ala Gln Leu 
        355                 360                 365             


Gln Leu Asn Ala Thr Glu Asn Asp Asp Arg Arg Ser Phe Phe Cys Asp 
    370                 375                 380                 


Ala Thr Leu Asp Val Asp Gly Glu Thr Leu Ile Lys Asn Arg Ser Ala 
385                 390                 395                 400 


Glu Leu Arg Val Leu Tyr Ala Pro Arg Leu Asp Asp Ser Asp Cys Pro 
                405                 410                 415     


Arg Ser Trp Thr Trp Pro Glu Gly Pro Glu Gln Thr Leu Arg Cys Glu 
            420                 425                 430         


Ala Arg Gly Asn Pro Glu Pro Ser Val His Cys Ala Arg Ser Asp Gly 
        435                 440                 445             


Gly Ala Val Leu Ala Leu Gly Leu Leu Gly Pro Val Thr Arg Ala Leu 
    450                 455                 460                 


Ser Gly Thr Tyr Arg Cys Lys Ala Ala Asn Asp Gln Gly Glu Ala Val 
465                 470                 475                 480 


Lys Asp Val Thr Leu Thr Val Glu Tyr Ala Pro Ala Leu Asp Ser Val 
                485                 490                 495     


Gly Cys Pro Glu Arg Ile Thr Trp Leu Glu Gly Thr Glu Ala Ser Leu 
            500                 505                 510         


Ser Cys Val Ala His Gly Val Pro Pro Pro Asp Val Ile Cys Val Arg 
        515                 520                 525             


Ser Gly Glu Leu Gly Ala Val Ile Glu Gly Leu Leu Arg Val Ala Arg 
    530                 535                 540                 


Glu His Ala Gly Thr Tyr Arg Cys Glu Ala Thr Asn Pro Arg Gly Ser 
545                 550                 555                 560 


Ala Ala Lys Asn Val Ala Val Thr Val Glu Tyr Gly Pro Arg Phe Glu 
                565                 570                 575     


Glu Pro Ser Cys Pro Ser Asn Trp Thr Trp Val Glu Gly Ser Gly Arg 
            580                 585                 590         


Leu Phe Ser Cys Glu Val Asp Gly Lys Pro Gln Pro Ser Val Lys Cys 
        595                 600                 605             


Val Gly Ser Gly Gly Ala Thr Glu Gly Val Leu Leu Pro Leu Ala Pro 
    610                 615                 620                 


Pro Asp Pro Ser Pro Arg Ala Pro Arg Ile Pro Arg Val Leu Ala Pro 
625                 630                 635                 640 


Gly Ile Tyr Val Cys Asn Ala Thr Asn Arg His Gly Ser Val Ala Lys 
                645                 650                 655     


Thr Val Val Val Ser Ala Glu Ser Pro Pro Glu Met Asp Glu Ser Thr 
            660                 665                 670         


Cys Pro Ser His Gln Thr Trp Leu Glu Gly Ala Glu Ala Ser Ala Leu 
        675                 680                 685             


Ala Cys Ala Ala Arg Gly Arg Pro Ser Pro Gly Val Arg Cys Ser Arg 
    690                 695                 700                 


Glu Gly Ile Pro Trp Pro Glu Gln Gln Arg Val Ser Arg Glu Asp Ala 
705                 710                 715                 720 


Gly Thr Tyr His Cys Val Ala Thr Asn Ala His Gly Thr Asp Ser Arg 
                725                 730                 735     


Thr Val Thr Val Gly Val Glu Tyr Arg Pro Val Val Ala Glu Leu Ala 
            740                 745                 750         


Ala Ser Pro Pro Gly Gly Val Arg Pro Gly Gly Asn Phe Thr Leu Thr 
        755                 760                 765             


Cys Arg Ala Glu Ala Trp Pro Pro Ala Gln Ile Ser Trp Arg Ala Pro 
    770                 775                 780                 


Pro Gly Ala Leu Asn Ile Gly Leu Ser Ser Asn Asn Ser Thr Leu Ser 
785                 790                 795                 800 


Val Ala Gly Ala Met Gly Ser His Gly Gly Glu Tyr Glu Cys Ala Arg 
                805                 810                 815     


Thr Asn Ala His Gly Arg His Ala Arg Arg Ile Thr Val Arg Val Ala 
            820                 825                 830         


Gly Pro Trp Leu Trp Val Ala Val Gly Gly Ala Ala Gly Gly Ala Ala 
        835                 840                 845             


Leu Leu Ala Ala Gly Ala Gly Leu Ala Phe Tyr Val Gln Ser Thr Ala 
    850                 855                 860                 


Cys Lys Lys Gly Glu Tyr Asn Val Gln Glu Ala Glu Ser Ser Gly Glu 
865                 870                 875                 880 


Ala Val Cys Leu Asn Gly Ala Gly Gly Gly Ala Gly Gly Ala Ala Gly 
                885                 890                 895     


Ala Glu Gly Gly Pro Glu Ala Ala Gly Gly Ala Ala Glu Ser Pro Ala 
            900                 905                 910         


Glu Gly Glu Val Phe Ala Ile Gln Leu Thr Ser Ala 
        915                 920                 


